PDB: 9O0V — 2 kinases

Total number of chains: 8
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 62.5% 9O0VA
DFGin BLAminus 1 12.5% 9O0VG
DFGin BLAplus 1 12.5% 9O0VE
DFGin BLBminus 1 12.5% 9O0VC

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K1 MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 9O0VG 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9O0VE 3.5 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1.5_Back 339 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9O0VC 3.5 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 324 Type1 339 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9O0VA 3.5 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_oioo 324 Type1.5_Back 339 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase

PDB: 9O0V — 2 kinases

Total number of chains: 8
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 62.5% 9O0VA
DFGin BLAminus 1 12.5% 9O0VG
DFGin BLAplus 1 12.5% 9O0VE
DFGin BLBminus 1 12.5% 9O0VC

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
TKL RAF1 RAF1_HUMAN 9O0VG 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 9O0VE 3.5 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1.5_Back 339 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 9O0VC 3.5 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 324 Type1 339 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 9O0VA 3.5 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_oioo 324 Type1.5_Back 339 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens

PDB: 9O0V — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism