TYR_NTRK1 (High affinity nerve growth factor receptor)

Total number of chains: 64
Active chains: 2
Uniprot: NTRK1_HUMAN
Kinase Domain Residues: 510 - 783
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 27 42.2% 4F0IB
DFGout BBAminus 17 26.6% 8J5XA
DFGin None 9 14.1% 7VKOA
DFGin ABAminus 6 9.4% 7VKNA
None None 3 4.7% 4YPSA
DFGin BLAminus 2 3.1% AF-P04629-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NTRK1 AF-P04629-K1A P04629 502 791 796.0 No_ligand No_ligand Active DFGin 7.164 14.3721 BLAminus -126.4, -168.05 48.95, 78.27 -90.55, 12.64 289.56, 90.19 -61.03, -31.73 in-in in 8.9777 Saltbr-in 2.8814 HRD-in -72.77, -40.89 66.37, -21.2 in-in-in SNCiii in-in ActLoopNT-in 2.9008 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.51, 136.89 APE9-dihe-in -128.62, 136.22 APE8-dihe-in -78.96, 62.95 APE8-rot-na 34.87 APE67-dihe-in -73.77, -14.24 -40.1, -43.39 APE12-dist-na 14.7108 APE11-dist-na 8.6715 APE10-dist-na 10.0114 APE9-dist-in 6.9069 None None None AF2 -1.0 1.0 1.0 A 290.0 290.0 0 30 30 0 [[510, 783]] 1.0 AF-P04629-K1 TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 AF-P04629-K3A P04629 502 791 796.0 No_ligand No_ligand Active DFGin 7.323 14.1523 BLAminus -129.69, -166.67 52.24, 63.22 -79.66, 9.74 296.19, 93.99 -60.65, -28.88 in-in in 9.2228 Saltbr-in 2.7511 HRD-in -73.08, -44.78 68.09, -10.06 in-in-in SNCiii in-in ActLoopNT-in 2.9104 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.13, 137.21 APE9-dihe-in -116.97, 144.96 APE8-dihe-in -76.62, 65.71 APE8-rot-na 37.35 APE67-dihe-in -74.52, -3.17 -47.64, -33.3 APE12-dist-na 14.4801 APE11-dist-na 9.2131 APE10-dist-na 11.2168 APE9-dist-in 6.7443 None None None AF2 -1.0 1.0 1.0 A 290.0 290.0 0 30 30 0 [[510, 783]] 1.0 AF-P04629-K3 TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KVTA P04629 501 787 796.0 YMX:60801 Type1 Inactive DFGin 6.0901 14.6402 ABAminus -123.93, -0.04 -156.57, 153.18 -119.59, 34.13 294.14, 82.51 42.35, 42.02 in-in in 9.2061 Saltbr-in 3.0656 HRD-in -72.66, -50.09 79.9, -10.34 in-out-in SNCioi out-in ActLoopNT-out 14.2458 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.61, 123.93 APE9-dihe-in -109.81, 133.19 APE8-dihe-in -81.57, 68.18 APE8-rot-na 37.74 APE67-dihe-in -59.58, -23.04 -58.72, -36.84 APE12-dist-na 12.336 APE11-dist-na 12.1641 APE10-dist-na 10.1176 APE9-dist-in 7.1005 None None None XRAY 2.45 0.195 0.239 A 293.0 283.0 4 30 30 0 [[510, 783]] 1.0 5kvt TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6IQNB P04629 502 788 796.0 AQ6:60801 Type1 Inactive DFGin 6.8017 15.0038 ABAminus -105.93, -21.08 -155.49, 154.25 -121.75, -62.07 303.57, 79.9 179.93, 999.0 out-out out 10.2417 Saltbr-out 7.062 HRD-in -80.44, -51.29 82.75, -12.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.38 APE8-dihe-in -85.76, 64.75 APE8-rot-na 31.54 APE67-dihe-in -69.39, -18.06 -57.29, -35.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6373 None None None XRAY 2.54 0.228 0.287 B 296.0 257.0 30 30 12 18 [[510, 783]] 1.0 6iqn TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4YNEA P04629 502 793 796.0 4EK:60801 Type1 Inactive DFGin 6.4621 14.4122 ABAminus -116.57, -25.87 -138.59, 132.08 -91.61, -8.55 292.59, 93.64 65.27, 48.21 in-out in 9.9537 Saltbr-out 4.2302 HRD-out -88.11, 116.02 -91.0, 8.56 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.59, 116.87 APE9-dihe-in -104.89, 127.5 APE8-dihe-in -70.7, 65.57 APE8-rot-na 30.51 APE67-dihe-in -68.75, -18.3 -60.63, -34.72 APE12-dist-na 999.0 APE11-dist-na 12.2405 APE10-dist-na 12.2039 APE9-dist-in 6.75 None None None XRAY 2.023 0.185 0.216 A 303.0 276.0 16 30 21 9 [[510, 783]] 1.0 4yne TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4AOJA P04629 500 789 796.0 V4Z:900 Type1 Inactive DFGin 7.0222 14.2755 ABAminus -110.98, -17.61 -143.63, 144.58 -112.81, -7.22 297.76, 85.92 -118.46, 999.0 in-in in 9.5528 Saltbr-in 2.9431 HRD-in -75.58, -50.98 84.9, -17.33 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.46, 125.37 APE9-dihe-in -125.37, 131.86 APE8-dihe-in -79.47, 66.97 APE8-rot-na 31.18 APE67-dihe-in -64.32, -24.98 -57.7, -37.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1484 None None None XRAY 2.75 0.221 0.242 A 329.0 260.0 30 30 14 16 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4AOJC P04629 500 789 796.0 V4Z:900 Type1 Inactive DFGin 6.9245 14.3181 ABAminus -113.25, -25.61 -134.45, 155.26 -115.79, 26.54 295.12, 82.68 85.56, -93.23 in-out in 9.5579 Saltbr-out 4.025 HRD-in -72.16, -45.71 73.74, -15.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.55 APE9-dihe-in -124.46, 135.84 APE8-dihe-in -82.75, 63.3 APE8-rot-na 24.35 APE67-dihe-in -63.5, -31.49 -48.92, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.5407 APE9-dist-in 7.0103 None None None XRAY 2.75 0.221 0.242 C 329.0 261.0 29 30 14 16 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 7VKNA P04629 502 794 796.0 7GI:60801 Type1 Inactive DFGin 5.9835 13.0168 ABAminus -115.39, -41.87 -131.41, 143.63 -111.24, 20.98 314.85, 71.2 75.66, -101.93 in-out in 9.3829 Saltbr-out 4.9157 HRD-out -83.04, 118.83 -102.62, 15.46 out-out-in SNCooi out-in ActLoopNT-out 12.754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.12, 137.74 APE9-dihe-in -119.62, 140.33 APE8-dihe-in -80.18, 72.83 APE8-rot-na 34.86 APE67-dihe-in -69.38, -23.62 -70.62, -21.09 APE12-dist-na 11.4199 APE11-dist-na 12.7924 APE10-dist-na 11.8576 APE9-dist-in 6.5849 G595R None None XRAY 2.7 0.186 0.256 A 326.0 292.0 1 30 29 1 [[510, 783]] 1.0 7vkn TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4PMTA P04629 501 787 796.0 31Y:60801 Type1 Inactive DFGin 6.1314 14.794 None -112.67, -17.01 -137.68, 145.04 -146.35, 999.0 322.04, 80.71 999.0, 999.0 in-out in 9.8065 Saltbr-out 3.6332 HRD-in -75.33, -51.24 80.98, -15.04 out-out-in SNCooi out-in ActLoopNT-out 15.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.06, 128.33 APE9-dihe-in -117.66, 131.56 APE8-dihe-in -80.54, 63.91 APE8-rot-na 31.59 APE67-dihe-in -62.62, -22.15 -50.58, -36.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2177 None None None XRAY 2.1 0.186 0.209 A 291.0 269.0 18 30 25 5 [[510, 783]] 1.0 4pmt TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5I8AA P04629 501 787 796.0 69C:60801 Type1 Inactive DFGin 6.738 14.3896 None -97.16, -113.31 -48.28, 144.89 -102.36, 10.49 289.66, 94.22 178.06, 999.0 in-in in 9.6286 Saltbr-in 3.266 HRD-in -70.07, -53.33 85.54, -20.79 in-out-in SNCioi out-in ActLoopNT-out 17.1271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.82, 123.59 APE9-dihe-in -112.87, 128.48 APE8-dihe-in -77.41, 62.86 APE8-rot-na 29.5 APE67-dihe-in -66.17, -22.6 -48.87, -35.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2452 None None None XRAY 2.33 0.18 0.209 A 296.0 266.0 21 30 26 4 [[510, 783]] 1.0 5i8a TYR_NTRK1_HUMAN TYR 1.7e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6IQNA P04629 502 790 796.0 AQ6:60801 Type1 Inactive DFGin 7.14 15.1103 None -103.61, -29.7 -117.2, -70.49 62.55, 999.0 316.84, 95.5 999.0, 999.0 in-out in 9.7917 Saltbr-out 4.8101 HRD-in -72.08, -53.46 85.54, -25.89 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.52, 109.29 APE9-dihe-in -102.41, 128.27 APE8-dihe-in -77.64, 69.03 APE8-rot-na 26.82 APE67-dihe-in -69.77, -22.47 -58.81, -29.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3302 None None None XRAY 2.54 0.228 0.287 A 296.0 271.0 18 30 18 12 [[510, 783]] 1.0 6iqn TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 7XAFA P04629 498 796 796.0 FKT:801 Type1 Inactive DFGin 10.9726 15.5303 None -141.15, 137.13 74.8, 177.08 49.53, -82.17 307.2, 139.07 -1.5, 80.75 in-out in 9.4808 Saltbr-out 3.7007 HRD-out -81.39, 105.98 -86.3, -0.43 out-out-in SNCooi out-in ActLoopNT-out 15.4378 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.83, 144.52 APE9-dihe-in -128.89, 123.51 APE8-dihe-in -76.16, 66.1 APE8-rot-na 29.0 APE67-dihe-in -71.14, -21.57 -60.15, -25.01 APE12-dist-na 15.0229 APE11-dist-na 14.3354 APE10-dist-na 10.4171 APE9-dist-in 7.3626 None None None XRAY 3.001 0.25 0.299 A 299.0 287.0 12 30 30 0 [[510, 783]] 1.0 7xaf TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6J5LA P04629 502 790 796.0 B9C:60801 Type1 Inactive DFGin 6.1274 13.7929 None -112.0, -17.65 -146.4, 142.64 -117.9, -119.21 307.69, 78.13 -102.52, 999.0 in-in in 9.3453 Saltbr-in 3.4221 HRD-out -88.88, 113.33 -93.5, 4.21 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.51, 126.2 APE9-dihe-in -111.04, 133.44 APE8-dihe-in -88.74, 66.42 APE8-rot-na 38.43 APE67-dihe-in -63.3, -23.33 -52.55, -36.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9327 None None None XRAY 2.3 0.224 0.251 A 303.0 278.0 11 30 23 7 [[510, 783]] 1.0 6j5l TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PMEB P04629 499 791 796.0 OOY:802 Type1 Inactive DFGin 8.0413 12.7752 None -108.23, 50.17 -34.62, -93.7 -97.7, 157.35 268.23, 140.64 158.45, -156.12 in-out in 9.6869 Saltbr-out 4.3617 HRD-in -75.61, -49.56 82.71, -16.4 out-out-none SNCoon out-none ActLoopNT-out 15.6778 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.79 APE9-dihe-in -136.64, 129.71 APE8-dihe-in -72.47, 62.28 APE8-rot-na 30.59 APE67-dihe-in -74.1, -16.42 -50.47, -31.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7569 APE9-dist-in 7.0187 None SEP677 SEP677 XRAY 3.0 0.259 0.315 B 311.0 271.0 22 30 25 5 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.3285 15.1025 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.6981 Saltbr-in 3.2532 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4955 None None None XRAY 2.864 0.22 0.277 A 320.0 264.0 32 30 11 19 [[510, 783]] 1.0 9dai TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 7VKOA P04629 502 793 796.0 7GI:60801 Type1 Inactive DFGin 6.3309 13.7935 None -121.29, -23.19 -130.55, 158.61 -131.43, -91.62 300.81, 84.28 -89.58, -178.74 in-out in 9.271 Saltbr-out 4.8438 HRD-out -83.55, 115.94 -93.33, 10.49 out-out-in SNCooi out-in ActLoopNT-out 15.2129 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.01, 135.08 APE9-dihe-in -120.4, 150.84 APE8-dihe-in -84.95, 78.96 APE8-rot-na 37.61 APE67-dihe-in -53.21, -25.59 -47.58, -54.99 APE12-dist-na 10.7383 APE11-dist-na 11.7728 APE10-dist-na 9.7313 APE9-dist-in 6.3483 None None None XRAY 2.9 0.188 0.267 A 326.0 292.0 0 30 30 0 [[510, 783]] 1.0 7vko TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4AOJB P04629 500 791 796.0 V4Z:900 Type1 Inactive DFGin 7.1015 14.487 None -112.8, -14.1 -146.85, 148.75 -118.66, 999.0 304.25, 74.79 999.0, 999.0 in-out in 9.7738 Saltbr-out 3.7833 HRD-in -81.07, -46.03 78.05, -27.65 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.18 APE8-dihe-in -83.87, 63.88 APE8-rot-na 24.55 APE67-dihe-in -64.26, -27.58 -47.61, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2365 None None None XRAY 2.75 0.221 0.242 B 329.0 258.0 34 30 11 19 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6DKGA P04629 500 796 796.0 22L:801,GO7:802 Allosteric,Type2 Inactive DFGout 15.4548 10.8854 BBAminus -129.84, -153.68 -169.97, 108.79 -76.62, -30.73 288.52, 72.75 116.03, 999.0 in-out in 9.8508 Saltbr-out 5.1091 HRD-in -69.9, -49.64 79.4, -12.32 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.62, 109.43 APE9-dihe-in -100.38, 134.76 APE8-dihe-in -83.29, 59.25 APE8-rot-na 32.8 APE67-dihe-in -64.09, -21.64 -42.0, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3571 None None None XRAY 2.53 0.189 0.225 A 320.0 276.0 21 30 21 9 [[510, 783]] 1.0 6dkg TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6DKIA P04629 500 796 796.0 22L:801,GOD:802 Allosteric,Type2 Inactive DFGout 15.6566 10.3394 BBAminus -138.27, -151.87 -172.63, 116.91 -81.37, -9.66 281.96, 77.97 75.28, 999.0 in-out in 9.8948 Saltbr-out 4.9127 HRD-in -65.87, -50.46 77.43, -14.55 out-out-in SNCooi out-in ActLoopNT-out 16.6148 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.45, 122.12 APE9-dihe-in -117.82, 128.28 APE8-dihe-in -76.01, 65.16 APE8-rot-na 30.62 APE67-dihe-in -68.36, -18.63 -49.98, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.307 None None None XRAY 2.11 0.186 0.227 A 320.0 279.0 18 30 24 6 [[510, 783]] 1.0 6dki TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6D1ZA P04629 483 796 796.0 FQD:801,FQM:803 Allosteric,Type3 Inactive DFGout 12.5668 7.3661 BBAminus 167.82, 150.89 -150.57, 163.47 -100.59, 23.19 306.23, 116.03 65.85, 23.26 in-out in 9.8538 Saltbr-out 6.197 HRD-in -66.06, -47.82 80.23, -21.06 out-out-in SNCooi out-in ActLoopNT-out 15.3022 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.79, 107.46 APE9-dihe-in -108.68, 135.71 APE8-dihe-in -79.15, 66.52 APE8-rot-na 33.74 APE67-dihe-in -68.05, -19.94 -54.02, -36.77 APE12-dist-na 999.0 APE11-dist-na 14.491 APE10-dist-na 10.8188 APE9-dist-in 7.2531 None None None XRAY 1.87 0.18 0.21 A 320.0 290.0 16 30 26 4 [[510, 783]] 1.0 6d1z TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 7VKMA P04629 502 795 796.0 No_ligand No_ligand Inactive DFGout 12.3226 7.4321 BBAminus 176.27, 165.41 -156.55, 175.73 -110.4, 8.5 305.75, 118.24 88.56, 16.82 in-out in 9.5677 Saltbr-out 4.9155 HRD-in -72.61, -55.29 84.51, -23.12 out-out-in SNCooi out-in ActLoopNT-out 15.6614 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.68, 125.36 APE9-dihe-in -117.44, 136.53 APE8-dihe-in -89.28, 75.32 APE8-rot-na 30.03 APE67-dihe-in -68.93, -24.54 -65.78, -30.21 APE12-dist-na 14.2495 APE11-dist-na 15.511 APE10-dist-na 10.8702 APE9-dist-in 7.2065 G595R None None XRAY 2.55 0.202 0.257 A 326.0 294.0 0 30 30 0 [[510, 783]] 1.0 7vkm TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4PMPA P04629 501 787 796.0 31W:60801 Type1 Inactive DFGout 15.4862 10.5504 BBAminus -133.03, -157.37 -173.03, 103.22 -69.9, -32.34 288.02, 70.73 77.22, -47.74 in-out in 9.5683 Saltbr-out 4.6471 HRD-in -67.48, -51.34 82.08, -14.32 out-out-in SNCooi out-in ActLoopNT-out 15.7318 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.87, 121.14 APE9-dihe-in -118.75, 136.28 APE8-dihe-in -80.92, 64.59 APE8-rot-na 34.05 APE67-dihe-in -64.12, -19.76 -49.55, -38.41 APE12-dist-na 999.0 APE11-dist-na 13.9146 APE10-dist-na 9.7347 APE9-dist-in 7.1901 None None None XRAY 1.8 0.166 0.185 A 291.0 276.0 11 30 27 3 [[510, 783]] 1.0 4pmp TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.7078 6.5827 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.4475 Saltbr-out 5.8508 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.8006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.7485 APE11-dist-na 15.1996 APE10-dist-na 10.6807 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324.0 303.0 10 30 30 0 [[510, 783]] 1.0 5h3q TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4PMMA P04629 501 787 796.0 31V:60801 Type2 Inactive DFGout 12.1455 10.95 BBAminus -133.43, -162.51 -156.69, 94.05 -92.35, -31.82 309.48, 143.39 59.02, -8.13 in-out in 9.2861 Saltbr-out 4.7596 HRD-in -72.63, -53.5 82.36, -15.27 out-out-in SNCooi out-in ActLoopNT-out 16.0948 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.51, 115.08 APE9-dihe-in -105.75, 129.0 APE8-dihe-in -80.23, 63.87 APE8-rot-na 30.48 APE67-dihe-in -66.31, -17.94 -46.68, -40.06 APE12-dist-na 13.7863 APE11-dist-na 15.797 APE10-dist-na 10.7596 APE9-dist-in 7.1451 None None None XRAY 2.0 0.166 0.199 A 291.0 281.0 6 30 30 0 [[510, 783]] 1.0 4pmm TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5JFSA P04629 502 793 796.0 6K0:64000 Type2 Inactive DFGout 12.5274 10.9828 BBAminus -135.78, -160.84 -157.76, 107.91 -107.26, 3.47 322.34, 129.58 106.13, 999.0 in-in in 9.8096 Saltbr-in 2.8877 HRD-in -71.87, -49.52 79.25, -12.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.58 APE8-dihe-in -83.43, 60.43 APE8-rot-na 33.02 APE67-dihe-in -63.9, -20.6 -49.99, -40.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5654 None None None XRAY 2.07 0.171 0.191 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfs TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5JFVA P04629 502 793 796.0 6K1:64000 Type2 Inactive DFGout 12.6383 11.028 BBAminus -141.43, -159.86 -155.63, 106.71 -102.51, 5.29 321.04, 131.31 88.83, 999.0 out-out out 10.053 Saltbr-out 3.8424 HRD-in -71.26, -49.89 78.63, -12.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.24 APE8-dihe-in -81.16, 59.69 APE8-rot-na 33.1 APE67-dihe-in -63.0, -20.76 -49.39, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5332 None None None XRAY 1.59 0.173 0.192 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfv TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5JFWA P04629 502 793 796.0 6K2:64000 Type2 Inactive DFGout 12.6588 11.1947 BBAminus -133.87, -158.13 -156.47, 107.62 -101.73, 2.97 321.78, 129.01 71.48, 999.0 out-out out 10.1959 Saltbr-out 8.1097 HRD-in -70.93, -50.56 80.08, -11.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.64 APE8-dihe-in -79.87, 59.55 APE8-rot-na 31.09 APE67-dihe-in -62.34, -22.4 -47.37, -43.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5174 None None None XRAY 1.52 0.18 0.209 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfw TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5JFXA P04629 502 793 796.0 6K4:64000 Type2 Inactive DFGout 12.7478 11.0402 BBAminus -133.96, -162.47 -154.94, 107.94 -100.19, 17.72 319.82, 130.69 65.97, 999.0 out-in out 10.1166 Saltbr-in 3.4793 HRD-in -70.26, -49.25 76.75, -14.14 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.45 APE8-dihe-in -81.06, 57.38 APE8-rot-na 33.47 APE67-dihe-in -62.32, -20.75 -46.26, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6498 None None None XRAY 1.63 0.203 0.232 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfx TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6DKWA P04629 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.7974 11.1466 BBAminus -132.36, -152.04 -163.87, 118.82 -86.57, 0.12 282.19, 82.2 87.26, 999.0 out-out out 10.036 Saltbr-out 7.7065 HRD-in -70.19, -47.29 72.43, -13.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.7 APE8-dihe-in -77.96, 56.47 APE8-rot-na 32.78 APE67-dihe-in -69.34, -24.62 -48.56, -36.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4575 None None None XRAY 2.91 0.233 0.262 A 308.0 271.0 21 30 12 18 [[510, 783]] 1.0 6dkw TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6DKWB P04629 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.3125 11.6643 BBAminus -137.72, -157.97 -167.56, 133.61 -110.92, -23.72 305.39, 77.76 119.48, 999.0 in-out in 9.8059 Saltbr-out 7.9525 HRD-in -71.64, -50.67 77.06, -19.15 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.56, 120.27 APE9-dihe-in -83.42, 115.11 APE8-dihe-in -79.02, 56.72 APE8-rot-na 32.67 APE67-dihe-in -66.06, -29.18 -49.12, -39.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8914 None None None XRAY 2.91 0.233 0.262 B 308.0 263.0 29 30 14 16 [[510, 783]] 1.0 6dkw TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PL2A P04629 499 795 796.0 OOM:801 Type2 Inactive DFGout 12.6124 11.7331 BBAminus -133.35, -162.35 -156.24, 113.82 -105.83, 45.09 316.55, 125.06 63.21, -157.53 in-out in 8.738 Saltbr-out 4.3488 HRD-in -67.21, -55.46 83.15, -23.62 out-out-in SNCooi out-in ActLoopNT-out 18.1791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.48, 132.06 APE9-dihe-in -120.18, 125.99 APE8-dihe-in -79.18, 69.41 APE8-rot-na 32.0 APE67-dihe-in -66.97, -17.29 -57.88, -39.56 APE12-dist-na 10.5006 APE11-dist-na 10.402 APE10-dist-na 5.7304 APE9-dist-in 7.3003 None SEP677 SEP677 XRAY 2.59 0.202 0.274 A 311.0 297.0 0 30 30 0 [[510, 783]] 1.0 6pl2 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 7XBIA P04629 497 795 796.0 CVY:801 Type2 Inactive DFGout 14.1066 10.7958 BBAminus -137.82, -164.37 -150.04, 97.3 -71.59, -9.66 278.32, 66.5 74.67, 31.7 in-out in 9.747 Saltbr-out 4.3181 HRD-in -82.22, -63.27 93.82, -12.28 out-out-in SNCooi out-in ActLoopNT-out 18.4232 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.41, 123.03 APE9-dihe-in -113.59, 129.96 APE8-dihe-in -80.4, 65.23 APE8-rot-na 30.24 APE67-dihe-in -62.07, -20.59 -54.97, -38.49 APE12-dist-na 10.5456 APE11-dist-na 11.0821 APE10-dist-na 6.2426 APE9-dist-in 7.2058 None None None XRAY 2.16 0.194 0.246 A 311.0 299.0 0 30 30 0 [[510, 783]] 1.0 7xbi TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 8J5XA P04629 500 795 796.0 A4U:801 Type2 Inactive DFGout 13.0357 10.3688 BBAminus -130.91, -158.27 -162.66, 108.46 -93.68, 5.06 291.9, 93.65 78.16, -167.64 in-in in 8.8892 Saltbr-in 2.6102 HRD-in -70.53, -55.33 83.0, -11.79 in-out-in SNCioi out-in ActLoopNT-out 18.3297 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.89, 140.84 APE9-dihe-in -129.21, 130.11 APE8-dihe-in -79.69, 64.42 APE8-rot-na 33.0 APE67-dihe-in -65.79, -20.2 -56.52, -34.65 APE12-dist-na 13.2974 APE11-dist-na 8.8947 APE10-dist-na 6.0299 APE9-dist-in 7.2178 G595R None None XRAY 2.092 0.184 0.22 A 299.0 296.0 0 30 30 0 [[510, 783]] 1.0 8j5x TYR_NTRK1_HUMAN TYR 9.7e-99 335.8 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PL4A P04629 485 795 796.0 OO7:801 Type3 Inactive DFGout 12.3312 6.751 BBAminus 163.32, 156.14 -161.4, 166.2 -103.41, 14.03 294.82, 105.0 75.38, 27.87 in-out in 9.5479 Saltbr-out 6.9473 HRD-in -67.83, -53.77 81.67, -11.19 out-out-in SNCooi out-in ActLoopNT-out 15.6773 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.06, 119.89 APE9-dihe-in -108.16, 133.15 APE8-dihe-in -81.07, 64.06 APE8-rot-na 35.11 APE67-dihe-in -63.69, -22.36 -54.01, -37.98 APE12-dist-na 13.7742 APE11-dist-na 15.0652 APE10-dist-na 10.8029 APE9-dist-in 7.2586 None SEP677 SEP677 XRAY 2.06 0.202 0.239 A 311.0 299.0 3 30 30 0 [[510, 783]] 1.0 6pl4 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6D20A P04629 482 796 796.0 FQD:801,FQG:802 Allosteric,Type3 Inactive DFGout 12.1211 7.6823 None 160.41, 153.19 -151.74, 163.05 -104.33, 22.77 307.7, 135.7 70.27, 21.28 out-out out 10.0112 Saltbr-out 4.832 HRD-in -65.64, -51.3 81.74, -20.54 out-out-in SNCooi out-in ActLoopNT-out 15.2703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.06, 110.16 APE9-dihe-in -105.1, 135.52 APE8-dihe-in -82.75, 65.28 APE8-rot-na 34.64 APE67-dihe-in -60.75, -21.14 -48.61, -41.93 APE12-dist-na 999.0 APE11-dist-na 15.3801 APE10-dist-na 10.9754 APE9-dist-in 7.2207 None None None XRAY 1.94 0.172 0.207 A 320.0 296.0 13 30 28 2 [[510, 783]] 1.0 6d20 TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4F0IA P04629 501 790 796.0 No_ligand No_ligand Inactive DFGout 12.7244 6.541 None 168.4, 147.46 -150.91, -178.97 -114.84, 17.84 296.33, 102.98 77.14, 17.47 out-out out 10.0716 Saltbr-out 3.7832 HRD-in -70.62, -54.37 86.42, -21.28 out-out-in SNCooi out-in ActLoopNT-out 15.4708 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.87, 117.07 APE9-dihe-in -123.33, 147.3 APE8-dihe-in -80.93, 68.13 APE8-rot-na 33.21 APE67-dihe-in -63.68, -22.55 -54.54, -38.97 APE12-dist-na 18.8871 APE11-dist-na 14.6754 APE10-dist-na 10.9186 APE9-dist-in 7.2309 None None None XRAY 2.302 0.185 0.241 A 300.0 284.0 6 30 30 0 [[510, 783]] 1.0 4f0i TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4F0IB P04629 501 794 796.0 No_ligand No_ligand Inactive DFGout 12.5434 7.0115 None 166.76, 148.15 -155.18, 178.64 -114.64, 15.88 300.05, 104.73 73.51, 23.99 in-out in 9.5461 Saltbr-out 3.6132 HRD-in -74.85, -50.62 80.22, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.4992 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.15, 119.22 APE9-dihe-in -115.7, 131.68 APE8-dihe-in -79.13, 66.63 APE8-rot-na 32.83 APE67-dihe-in -65.29, -20.15 -62.09, -33.78 APE12-dist-na 15.6478 APE11-dist-na 15.2052 APE10-dist-na 10.6707 APE9-dist-in 7.475 None None None XRAY 2.302 0.185 0.241 B 300.0 294.0 0 30 30 0 [[510, 783]] 1.0 4f0i TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4GT5A P04629 498 793 796.0 No_ligand No_ligand Inactive DFGout 12.6043 7.3471 None 159.19, 156.78 -162.75, 171.4 -109.98, 15.11 307.11, 107.92 73.58, 34.63 in-none in 9.7567 Saltbr-none 999.0 HRD-in -59.3, -59.24 86.11, -5.83 none-out-in SNCnoi out-in ActLoopNT-out 15.7975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.6, 126.13 APE9-dihe-in -108.71, 129.99 APE8-dihe-in -77.33, 65.58 APE8-rot-na 28.73 APE67-dihe-in -65.65, -17.34 -57.96, -37.68 APE12-dist-na 15.1467 APE11-dist-na 15.3699 APE10-dist-na 11.2291 APE9-dist-in 7.4443 None None None XRAY 2.398 0.204 0.248 A 306.0 290.0 6 30 30 0 [[510, 783]] 1.0 4gt5 TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6D22A P04629 502 794 796.0 No_ligand No_ligand Inactive DFGout 12.606 7.1432 None 175.88, 158.7 -166.39, 174.44 -112.95, 15.95 304.35, 111.16 86.04, 4.07 in-out in 9.6133 Saltbr-out 3.848 HRD-in -74.57, -54.54 85.84, -16.79 out-out-in SNCooi out-in ActLoopNT-out 15.8411 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.68, 117.35 APE9-dihe-in -107.64, 132.88 APE8-dihe-in -74.3, 62.56 APE8-rot-na 38.38 APE67-dihe-in -63.87, -17.11 -48.79, -48.38 APE12-dist-na 13.8949 APE11-dist-na 15.2645 APE10-dist-na 10.9497 APE9-dist-in 7.5774 None None None XRAY 2.46 0.178 0.236 A 307.0 293.0 0 30 30 0 [[510, 783]] 1.0 6d22 TYR_NTRK1_HUMAN TYR 2e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6DKBA P04629 501 796 796.0 FKY:4000 Type1 Inactive DFGout 15.3321 10.7475 None -132.31, -154.04 -173.63, 117.2 -89.02, -138.07 293.55, 87.71 -145.33, 999.0 out-in out 10.0153 Saltbr-in 3.3428 HRD-in -63.64, -46.04 75.89, -18.83 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 136.46 APE9-dihe-in -131.13, 141.89 APE8-dihe-in -81.0, 68.63 APE8-rot-na 33.49 APE67-dihe-in -61.76, -21.1 -51.01, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2727 None None None XRAY 2.68 0.217 0.245 A 320.0 272.0 24 30 19 11 [[510, 783]] 1.0 6dkb TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMOA P04629 500 796 796.0 6UM:60901 Type1 Inactive DFGout 12.3188 11.3736 None -138.6, -165.07 -158.74, 98.32 -111.51, -171.02 340.4, 114.97 156.89, 999.0 out-out out 10.6308 Saltbr-out 6.3163 HRD-in -66.47, -58.38 85.91, -20.7 out-out-in SNCooi out-in ActLoopNT-out 17.2212 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.17, 145.62 APE9-dihe-in -124.84, 130.96 APE8-dihe-in -87.13, 68.95 APE8-rot-na 25.74 APE67-dihe-in -56.92, -24.53 -50.66, -48.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1614 None None None XRAY 2.67 0.196 0.243 A 329.0 290.0 7 30 28 2 [[510, 783]] 1.0 5kmo TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4PMSA P04629 501 787 796.0 31X:60801 Type1.5_Back Inactive DFGout 12.026 11.6074 None -132.53, -155.25 -159.75, 97.5 -105.99, 141.7 318.1, 112.95 -75.26, -27.15 in-out in 9.4706 Saltbr-out 6.4616 HRD-in -62.95, -59.22 88.04, -25.42 out-out-in SNCooi out-in ActLoopNT-out 15.9197 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 110.83 APE9-dihe-in -104.11, 139.32 APE8-dihe-in -84.02, 66.3 APE8-rot-na 28.87 APE67-dihe-in -67.29, -19.63 -45.69, -39.43 APE12-dist-na 17.3848 APE11-dist-na 17.1424 APE10-dist-na 12.4834 APE9-dist-in 7.2332 None None None XRAY 2.8 0.168 0.24 A 291.0 279.0 8 30 28 2 [[510, 783]] 1.0 4pms TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 8J5WA P04629 485 795 796.0 A4U:801 Type2 Inactive DFGout 14.1063 9.9042 None -124.93, -156.11 -165.36, 86.03 -59.52, 147.81 290.47, 86.44 107.07, -85.27 in-out in 9.5724 Saltbr-out 6.0721 HRD-out -97.68, 106.96 -81.54, 7.53 out-out-in SNCooi out-in ActLoopNT-out 16.096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.59, 129.11 APE9-dihe-in -117.85, 126.3 APE8-dihe-in -74.82, 63.31 APE8-rot-na 31.0 APE67-dihe-in -67.5, -17.44 -56.64, -33.03 APE12-dist-na 15.4415 APE11-dist-na 16.0691 APE10-dist-na 11.3999 APE9-dist-in 7.0397 F589L None None XRAY 2.28 0.222 0.266 A 313.0 298.0 4 30 30 0 [[510, 783]] 1.0 8j5w TYR_NTRK1_HUMAN TYR 2.6e-100 340.9 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 8J61A P04629 499 795 796.0 A0X:801 Type2 Inactive DFGout 13.2302 11.1552 None -134.57, -179.08 -139.19, 96.75 -83.33, 178.03 307.14, 171.93 171.37, -120.57 out-out out 10.1094 Saltbr-out 6.4555 HRD-in -80.6, -37.38 66.53, -21.87 out-out-in SNCooi out-in ActLoopNT-out 15.5742 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -141.71, 130.82 APE9-dihe-in -115.65, 127.68 APE8-dihe-in -74.28, 70.21 APE8-rot-na 29.28 APE67-dihe-in -73.67, -7.76 -58.39, -28.44 APE12-dist-na 16.7752 APE11-dist-na 15.1622 APE10-dist-na 11.5782 APE9-dist-in 6.9973 None None None XRAY 3.051 0.209 0.255 A 299.0 291.0 6 30 30 0 [[510, 783]] 1.0 8j61 TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 8J63A P04629 500 796 796.0 A6X:801 Type2 Inactive DFGout 13.7582 10.3144 None -148.15, -172.21 -147.6, 96.08 -75.43, 162.83 293.22, 106.5 105.33, -112.14 in-out in 9.8194 Saltbr-out 4.2447 HRD-in -78.37, -44.48 66.44, -4.46 out-out-in SNCooi out-in ActLoopNT-out 15.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.3, 149.87 APE9-dihe-in -128.22, 125.62 APE8-dihe-in -76.56, 58.46 APE8-rot-na 30.42 APE67-dihe-in -72.95, -14.47 -58.85, -23.58 APE12-dist-na 17.2827 APE11-dist-na 16.1057 APE10-dist-na 11.8492 APE9-dist-in 7.2566 None None None XRAY 3.001 0.233 0.289 A 299.0 291.0 6 30 30 0 [[510, 783]] 1.0 8j63 TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5WR7A P04629 489 792 796.0 RCH:801 Type2 Inactive DFGout 14.6633 8.4308 None -131.73, -148.47 -166.21, 161.63 -141.28, 117.22 276.93, 88.17 -99.45, -3.58 out-out out 10.1911 Saltbr-out 7.4254 HRD-in -69.6, -49.89 70.97, 2.48 out-out-in SNCooi out-in ActLoopNT-out 18.1253 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.65, 116.34 APE9-dihe-in -122.66, 128.76 APE8-dihe-in -78.54, 68.52 APE8-rot-na 32.36 APE67-dihe-in -68.82, -19.66 -50.73, -45.45 APE12-dist-na 999.0 APE11-dist-na 14.9273 APE10-dist-na 10.0895 APE9-dist-in 7.0416 None SEP677 SEP677 XRAY 2.76 0.208 0.234 A 304.0 302.0 2 30 28 2 [[510, 783]] 1.0 5wr7 TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PL1A P04629 500 795 796.0 OOJ:801 Type2 Inactive DFGout 12.2018 11.5453 None -140.12, -163.59 -151.72, 95.42 -94.74, 114.97 323.02, 137.75 -51.78, -31.38 in-out in 9.5369 Saltbr-out 4.2536 HRD-in -65.5, -55.98 80.9, -7.13 out-out-in SNCooi out-in ActLoopNT-out 16.0161 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.78, 119.43 APE9-dihe-in -106.09, 130.79 APE8-dihe-in -83.67, 66.03 APE8-rot-na 34.24 APE67-dihe-in -63.93, -22.81 -49.57, -43.95 APE12-dist-na 999.0 APE11-dist-na 15.2277 APE10-dist-na 10.758 APE9-dist-in 7.134 None SEP677 SEP677 XRAY 2.03 0.22 0.26 A 311.0 290.0 6 30 27 3 [[510, 783]] 1.0 6pl1 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PL3A P04629 500 795 796.0 OOD:801 Type2 Inactive DFGout 11.5644 10.9099 None -143.28, -158.28 -155.92, 104.62 -110.35, 130.24 309.4, 131.25 -70.56, -23.22 in-out in 9.2687 Saltbr-out 3.683 HRD-in -79.21, -48.25 72.7, -2.08 out-out-in SNCooi out-in ActLoopNT-out 16.4738 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.4, 114.8 APE9-dihe-in -102.82, 125.91 APE8-dihe-in -81.39, 70.95 APE8-rot-na 32.5 APE67-dihe-in -65.12, -18.02 -56.45, -36.14 APE12-dist-na 15.256 APE11-dist-na 16.2849 APE10-dist-na 11.683 APE9-dist-in 7.2155 None None None XRAY 3.0 0.211 0.272 A 311.0 291.0 5 30 30 0 [[510, 783]] 1.0 6pl3 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PMAA P04629 500 795 796.0 OQS:801 Type2 Inactive DFGout 12.1218 11.2768 None -135.79, -172.95 -145.14, 102.3 -103.72, 124.51 321.1, 137.33 -54.09, -40.43 in-in in 9.0466 Saltbr-in 2.5914 HRD-in -75.81, -50.56 78.93, -17.98 in-out-in SNCioi out-in ActLoopNT-out 16.0904 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -134.69, 117.23 APE9-dihe-in -107.06, 120.83 APE8-dihe-in -77.63, 65.04 APE8-rot-na 27.44 APE67-dihe-in -72.95, -15.51 -57.1, -33.54 APE12-dist-na 15.9114 APE11-dist-na 15.6675 APE10-dist-na 10.9989 APE9-dist-in 7.2636 None SEP677 SEP677 XRAY 2.53 0.209 0.266 A 311.0 290.0 6 30 30 0 [[510, 783]] 1.0 6pma TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PMBA P04629 500 795 796.0 OQM:801 Type2 Inactive DFGout 11.6598 11.6719 None -132.37, -159.76 -148.31, 103.43 -105.33, 151.54 318.17, 135.0 -87.93, -24.35 in-in in 9.1747 Saltbr-in 3.4604 HRD-in -70.6, -56.1 77.89, -14.23 in-out-in SNCioi out-in ActLoopNT-out 16.0755 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.62, 125.62 APE9-dihe-in -118.02, 123.95 APE8-dihe-in -78.96, 65.2 APE8-rot-na 32.2 APE67-dihe-in -67.87, -21.55 -67.55, -29.76 APE12-dist-na 15.6492 APE11-dist-na 16.5776 APE10-dist-na 11.6952 APE9-dist-in 7.1864 None None None XRAY 2.81 0.219 0.282 A 311.0 288.0 8 30 30 0 [[510, 783]] 1.0 6pmb TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PMCA P04629 500 795 796.0 OQJ:801 Type2 Inactive DFGout 11.8075 11.813 None -132.04, -168.64 -145.63, 90.01 -97.69, 142.15 324.37, 130.77 -66.35, -36.3 in-in in 9.6514 Saltbr-in 3.5266 HRD-in -82.16, -55.48 89.25, -24.57 in-out-in SNCioi out-in ActLoopNT-out 15.9744 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.7, 118.63 APE9-dihe-in -108.33, 130.52 APE8-dihe-in -80.54, 62.41 APE8-rot-na 37.39 APE67-dihe-in -54.69, -23.0 -49.98, -41.68 APE12-dist-na 14.1544 APE11-dist-na 15.6807 APE10-dist-na 11.2356 APE9-dist-in 7.2264 None SEP677 SEP677 XRAY 2.19 0.25 0.298 A 311.0 289.0 7 30 30 0 [[510, 783]] 1.0 6pmc TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6NSPA P04629 500 795 796.0 L0P:801 Type3 Inactive DFGout 12.3408 6.9177 None 147.69, 153.73 -147.15, -178.06 -113.86, 11.77 292.26, 110.9 67.54, 37.24 in-out in 9.5059 Saltbr-out 9.102 HRD-in -80.74, -60.67 84.66, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.6895 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -135.01, 112.02 APE9-dihe-in -104.87, 129.45 APE8-dihe-in -77.35, 65.98 APE8-rot-na 35.66 APE67-dihe-in -61.95, -17.33 -58.27, -39.42 APE12-dist-na 13.388 APE11-dist-na 15.0547 APE10-dist-na 10.6609 APE9-dist-in 7.3709 None None None XRAY 2.31 0.192 0.255 A 297.0 293.0 3 30 30 0 [[510, 783]] 1.0 6nsp TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6NPTA P04629 491 795 796.0 KWY:801 Type3 Inactive DFGout 12.4381 7.5007 None 158.18, 155.8 -152.05, 169.87 -107.1, 19.78 311.07, 121.3 72.87, 27.1 out-out out 10.0081 Saltbr-out 5.2384 HRD-in -70.4, -52.75 80.08, -14.8 out-out-in SNCooi out-in ActLoopNT-out 15.5916 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.83, 113.75 APE9-dihe-in -105.63, 131.16 APE8-dihe-in -80.28, 65.31 APE8-rot-na 34.86 APE67-dihe-in -61.58, -17.65 -56.43, -41.31 APE12-dist-na 14.4263 APE11-dist-na 15.1866 APE10-dist-na 10.6476 APE9-dist-in 7.2622 None SEP677 SEP677 XRAY 2.19 0.227 0.276 A 305.0 288.0 10 30 30 0 [[510, 783]] 1.0 6npt TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6NSSA P04629 485 795 796.0 L0M:801 Type3 Inactive DFGout 11.8151 7.0253 None 168.65, 153.78 -158.36, 171.84 -109.19, 24.3 297.57, 118.56 67.82, 28.96 in-out in 9.528 Saltbr-out 5.6657 HRD-in -90.15, -59.03 81.79, -5.07 out-out-in SNCooi out-in ActLoopNT-out 16.0664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.54, 111.04 APE9-dihe-in -105.46, 130.52 APE8-dihe-in -80.81, 65.09 APE8-rot-na 33.3 APE67-dihe-in -66.94, -20.44 -58.3, -34.71 APE12-dist-na 13.0683 APE11-dist-na 15.0175 APE10-dist-na 10.6868 APE9-dist-in 7.4489 None None None XRAY 1.97 0.184 0.218 A 311.0 303.0 3 30 30 0 [[510, 783]] 1.0 6nss TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6D1YA P04629 481 796 796.0 FQJ:801 Type3 Inactive DFGout 12.6733 6.8555 None 169.8, 145.64 -149.42, -179.74 -114.54, 6.91 301.35, 101.16 76.21, 25.01 out-out out 10.0516 Saltbr-out 5.4416 HRD-in -65.07, -51.13 81.32, -20.97 out-out-in SNCooi out-in ActLoopNT-out 15.4706 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.27, 120.93 APE9-dihe-in -115.22, 138.24 APE8-dihe-in -78.51, 63.15 APE8-rot-na 29.74 APE67-dihe-in -66.08, -21.72 -48.21, -36.42 APE12-dist-na 999.0 APE11-dist-na 14.923 APE10-dist-na 10.7086 APE9-dist-in 7.2537 None None None XRAY 1.93 0.179 0.224 A 320.0 300.0 16 30 26 4 [[510, 783]] 1.0 6d1y TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMIA P04629 486 796 796.0 6UE:901 Type3 Inactive DFGout 12.1021 7.2926 None 161.69, 152.83 -154.44, 168.25 -105.96, 25.99 305.3, 125.58 65.11, 30.06 in-out in 9.4863 Saltbr-out 6.201 HRD-in -70.33, -55.53 75.77, -9.09 out-out-in SNCooi out-in ActLoopNT-out 15.7575 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.77, 111.89 APE9-dihe-in -104.52, 130.31 APE8-dihe-in -84.87, 65.08 APE8-rot-na 32.16 APE67-dihe-in -62.84, -22.31 -53.23, -38.24 APE12-dist-na 14.0032 APE11-dist-na 15.6542 APE10-dist-na 10.9157 APE9-dist-in 7.5288 None None None XRAY 1.87 0.21 0.247 A 329.0 300.0 6 30 30 0 [[510, 783]] 1.0 5kmi TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.6023 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.7145 Saltbr-in 2.7723 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.1073 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.0163 APE11-dist-na 15.494 APE10-dist-na 11.0956 APE9-dist-in 7.6003 None None None XRAY 2.04 0.196 0.226 A 329.0 300.0 6 30 30 0 [[510, 783]] 1.0 5kmj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMKA P04629 484 796 796.0 6UG:60901 Type3 Inactive DFGout 12.3673 7.4438 None 155.23, 152.12 -152.95, 175.79 -116.52, 20.57 308.16, 114.44 75.73, 21.77 in-out in 9.7632 Saltbr-out 6.3973 HRD-in -59.42, -51.85 75.91, -16.02 out-out-in SNCooi out-in ActLoopNT-out 15.4709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.53, 119.76 APE9-dihe-in -107.42, 137.31 APE8-dihe-in -83.03, 63.78 APE8-rot-na 29.2 APE67-dihe-in -62.44, -17.14 -49.56, -42.83 APE12-dist-na 14.0289 APE11-dist-na 15.4162 APE10-dist-na 11.1025 APE9-dist-in 7.2499 None None None XRAY 2.24 0.227 0.281 A 329.0 302.0 5 30 30 0 [[510, 783]] 1.0 5kmk TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMMA P04629 484 796 796.0 6UJ:60901 Type3 Inactive DFGout 12.3683 7.1842 None 157.73, 155.5 -160.68, 165.48 -107.15, 26.91 307.0, 120.61 71.24, 15.54 in-out in 9.463 Saltbr-out 5.1138 HRD-in -61.78, -57.27 78.61, -13.21 out-out-in SNCooi out-in ActLoopNT-out 15.6626 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.76, 118.16 APE9-dihe-in -103.64, 132.25 APE8-dihe-in -82.99, 66.28 APE8-rot-na 32.09 APE67-dihe-in -66.37, -19.35 -53.37, -35.26 APE12-dist-na 13.5484 APE11-dist-na 15.6333 APE10-dist-na 11.2071 APE9-dist-in 7.4278 None None None XRAY 2.12 0.216 0.264 A 329.0 300.0 5 30 30 0 [[510, 783]] 1.0 5kmm TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMLA P04629 474 796 796.0 6UH:60901 Type3 Inactive DFGout 12.3981 7.2825 None 158.81, 154.45 -158.96, 169.19 -111.19, 29.55 308.68, 112.5 65.84, 21.76 in-out in 9.9569 Saltbr-out 5.2259 HRD-out -95.27, 113.75 -82.3, 1.42 out-out-in SNCooi out-in ActLoopNT-out 16.0097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.36, 117.18 APE9-dihe-in -101.68, 134.53 APE8-dihe-in -83.65, 62.57 APE8-rot-na 32.66 APE67-dihe-in -60.72, -23.67 -48.68, -40.28 APE12-dist-na 14.5118 APE11-dist-na 15.2496 APE10-dist-na 11.0243 APE9-dist-in 7.223 None None None XRAY 2.01 0.204 0.232 A 330.0 296.0 8 30 30 0 [[510, 783]] 1.0 5kml TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 5KMNA P04629 474 796 796.0 6UK:60901 Type3 Inactive DFGout 12.5503 7.5403 None 154.23, 154.5 -157.96, 168.93 -109.62, 31.32 313.55, 117.07 68.77, 19.82 in-out in 9.8895 Saltbr-out 4.9957 HRD-out -100.52, 112.12 -80.72, -0.22 out-out-in SNCooi out-in ActLoopNT-out 16.1678 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.74, 114.86 APE9-dihe-in -100.75, 133.2 APE8-dihe-in -82.26, 61.08 APE8-rot-na 30.54 APE67-dihe-in -63.96, -19.55 -48.16, -39.69 APE12-dist-na 14.5609 APE11-dist-na 15.3668 APE10-dist-na 11.1626 APE9-dist-in 7.3231 None None None XRAY 2.14 0.195 0.222 A 330.0 296.0 8 30 30 0 [[510, 783]] 1.0 5kmn TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 4YPSA P04629 502 790 796.0 4F6:60801 Type1 Inactive None 999.0 999.0 None -112.08, -158.35 4.87, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.117 Saltbr-out 9.1251 HRD-out -86.73, 118.76 -94.8, 9.98 out-out-in SNCooi out-in ActLoopNT-out 17.7427 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.0, 118.89 APE9-dihe-in -107.28, 139.4 APE8-dihe-in -81.62, 61.84 APE8-rot-na 34.18 APE67-dihe-in -64.91, -18.75 -58.48, -35.44 APE12-dist-na 999.0 APE11-dist-na 14.6064 APE10-dist-na 10.3213 APE9-dist-in 7.2262 None None None XRAY 2.101 0.203 0.257 A 303.0 275.0 14 30 25 5 [[510, 783]] 1.0 4yps TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PMEA P04629 500 788 796.0 OOY:802 Type1 Inactive None 11.2737 14.866 None -103.64, 63.03 -6.61, -101.22 -108.6, -79.47 316.94, 83.99 80.48, -131.89 in-out in 9.6502 Saltbr-out 4.1971 HRD-in -82.82, -49.18 87.37, -21.9 out-out-in SNCooi out-in ActLoopNT-out 15.6261 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.61, 116.38 APE9-dihe-in -119.8, 127.41 APE8-dihe-in -74.42, 64.21 APE8-rot-na 33.13 APE67-dihe-in -65.79, -8.94 -53.59, -37.65 APE12-dist-na 999.0 APE11-dist-na 14.3493 APE10-dist-na 10.4008 APE9-dist-in 7.1239 None SEP677 SEP677 XRAY 3.0 0.259 0.315 A 311.0 268.0 21 30 27 3 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 6PMEC P04629 500 790 796.0 OOY:802 Type1 Inactive None 11.5194 15.0044 None -105.17, 39.93 27.01, -158.9 -47.91, -126.82 299.14, 109.98 111.56, -123.09 in-out in 9.6725 Saltbr-out 4.9611 HRD-in -71.5, -57.03 89.79, -15.29 out-out-in SNCooi out-in ActLoopNT-out 15.6199 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.99, 111.57 APE9-dihe-in -114.5, 136.16 APE8-dihe-in -76.15, 63.17 APE8-rot-na 31.13 APE67-dihe-in -65.29, -26.47 -45.99, -41.18 APE12-dist-na 16.0835 APE11-dist-na 14.6809 APE10-dist-na 10.6659 APE9-dist-in 6.9642 None SEP677 SEP677 XRAY 3.0 0.259 0.315 C 311.0 274.0 17 30 28 2 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor

TYR_NTRK1 (High affinity nerve growth factor receptor)

Total number of chains: 64
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 27 42.2% 4F0IB
DFGout BBAminus 17 26.6% 8J5XA
DFGin None 9 14.1% 7VKOA
DFGin ABAminus 6 9.4% 7VKNA
None None 3 4.7% 4YPSA
DFGin BLAminus 2 3.1% AF-P04629-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NTRK1 NTRK1_HUMAN AF-P04629-K1A P04629 502 791 796.0 No_ligand No_ligand Active DFGin 7.164 14.3721 BLAminus -126.4, -168.05 48.95, 78.27 -90.55, 12.64 289.56, 90.19 -61.03, -31.73 in-in in 8.9777 Saltbr-in 2.8814 HRD-in -72.77, -40.89 66.37, -21.2 in-in-in SNCiii in-in ActLoopNT-in 2.9008 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.51, 136.89 APE9-dihe-in -128.62, 136.22 APE8-dihe-in -78.96, 62.95 APE8-rot-na 34.87 APE67-dihe-in -73.77, -14.24 -40.1, -43.39 APE12-dist-na 14.7108 APE11-dist-na 8.6715 APE10-dist-na 10.0114 APE9-dist-in 6.9069 None None None AF2 -1.0 1.0 1.0 A 290.0 290.0 0 30 30 0 [[510, 783]] 1.0 AF-P04629-K1 Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN AF-P04629-K3A P04629 502 791 796.0 No_ligand No_ligand Active DFGin 7.323 14.1523 BLAminus -129.69, -166.67 52.24, 63.22 -79.66, 9.74 296.19, 93.99 -60.65, -28.88 in-in in 9.2228 Saltbr-in 2.7511 HRD-in -73.08, -44.78 68.09, -10.06 in-in-in SNCiii in-in ActLoopNT-in 2.9104 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.13, 137.21 APE9-dihe-in -116.97, 144.96 APE8-dihe-in -76.62, 65.71 APE8-rot-na 37.35 APE67-dihe-in -74.52, -3.17 -47.64, -33.3 APE12-dist-na 14.4801 APE11-dist-na 9.2131 APE10-dist-na 11.2168 APE9-dist-in 6.7443 None None None AF2 -1.0 1.0 1.0 A 290.0 290.0 0 30 30 0 [[510, 783]] 1.0 AF-P04629-K3 Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KVTA P04629 501 787 796.0 YMX:60801 Type1 Inactive DFGin 6.0901 14.6402 ABAminus -123.93, -0.04 -156.57, 153.18 -119.59, 34.13 294.14, 82.51 42.35, 42.02 in-in in 9.2061 Saltbr-in 3.0656 HRD-in -72.66, -50.09 79.9, -10.34 in-out-in SNCioi out-in ActLoopNT-out 14.2458 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.61, 123.93 APE9-dihe-in -109.81, 133.19 APE8-dihe-in -81.57, 68.18 APE8-rot-na 37.74 APE67-dihe-in -59.58, -23.04 -58.72, -36.84 APE12-dist-na 12.336 APE11-dist-na 12.1641 APE10-dist-na 10.1176 APE9-dist-in 7.1005 None None None XRAY 2.45 0.195 0.239 A 293.0 283.0 4 30 30 0 [[510, 783]] 1.0 5kvt Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6IQNB P04629 502 788 796.0 AQ6:60801 Type1 Inactive DFGin 6.8017 15.0038 ABAminus -105.93, -21.08 -155.49, 154.25 -121.75, -62.07 303.57, 79.9 179.93, 999.0 out-out out 10.2417 Saltbr-out 7.062 HRD-in -80.44, -51.29 82.75, -12.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.38 APE8-dihe-in -85.76, 64.75 APE8-rot-na 31.54 APE67-dihe-in -69.39, -18.06 -57.29, -35.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6373 None None None XRAY 2.54 0.228 0.287 B 296.0 257.0 30 30 12 18 [[510, 783]] 1.0 6iqn Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4YNEA P04629 502 793 796.0 4EK:60801 Type1 Inactive DFGin 6.4621 14.4122 ABAminus -116.57, -25.87 -138.59, 132.08 -91.61, -8.55 292.59, 93.64 65.27, 48.21 in-out in 9.9537 Saltbr-out 4.2302 HRD-out -88.11, 116.02 -91.0, 8.56 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.59, 116.87 APE9-dihe-in -104.89, 127.5 APE8-dihe-in -70.7, 65.57 APE8-rot-na 30.51 APE67-dihe-in -68.75, -18.3 -60.63, -34.72 APE12-dist-na 999.0 APE11-dist-na 12.2405 APE10-dist-na 12.2039 APE9-dist-in 6.75 None None None XRAY 2.023 0.185 0.216 A 303.0 276.0 16 30 21 9 [[510, 783]] 1.0 4yne Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4AOJA P04629 500 789 796.0 V4Z:900 Type1 Inactive DFGin 7.0222 14.2755 ABAminus -110.98, -17.61 -143.63, 144.58 -112.81, -7.22 297.76, 85.92 -118.46, 999.0 in-in in 9.5528 Saltbr-in 2.9431 HRD-in -75.58, -50.98 84.9, -17.33 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.46, 125.37 APE9-dihe-in -125.37, 131.86 APE8-dihe-in -79.47, 66.97 APE8-rot-na 31.18 APE67-dihe-in -64.32, -24.98 -57.7, -37.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1484 None None None XRAY 2.75 0.221 0.242 A 329.0 260.0 30 30 14 16 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4AOJC P04629 500 789 796.0 V4Z:900 Type1 Inactive DFGin 6.9245 14.3181 ABAminus -113.25, -25.61 -134.45, 155.26 -115.79, 26.54 295.12, 82.68 85.56, -93.23 in-out in 9.5579 Saltbr-out 4.025 HRD-in -72.16, -45.71 73.74, -15.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.55 APE9-dihe-in -124.46, 135.84 APE8-dihe-in -82.75, 63.3 APE8-rot-na 24.35 APE67-dihe-in -63.5, -31.49 -48.92, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.5407 APE9-dist-in 7.0103 None None None XRAY 2.75 0.221 0.242 C 329.0 261.0 29 30 14 16 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 7VKNA P04629 502 794 796.0 7GI:60801 Type1 Inactive DFGin 5.9835 13.0168 ABAminus -115.39, -41.87 -131.41, 143.63 -111.24, 20.98 314.85, 71.2 75.66, -101.93 in-out in 9.3829 Saltbr-out 4.9157 HRD-out -83.04, 118.83 -102.62, 15.46 out-out-in SNCooi out-in ActLoopNT-out 12.754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.12, 137.74 APE9-dihe-in -119.62, 140.33 APE8-dihe-in -80.18, 72.83 APE8-rot-na 34.86 APE67-dihe-in -69.38, -23.62 -70.62, -21.09 APE12-dist-na 11.4199 APE11-dist-na 12.7924 APE10-dist-na 11.8576 APE9-dist-in 6.5849 G595R None None XRAY 2.7 0.186 0.256 A 326.0 292.0 1 30 29 1 [[510, 783]] 1.0 7vkn Homo sapiens TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4PMTA P04629 501 787 796.0 31Y:60801 Type1 Inactive DFGin 6.1314 14.794 None -112.67, -17.01 -137.68, 145.04 -146.35, 999.0 322.04, 80.71 999.0, 999.0 in-out in 9.8065 Saltbr-out 3.6332 HRD-in -75.33, -51.24 80.98, -15.04 out-out-in SNCooi out-in ActLoopNT-out 15.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.06, 128.33 APE9-dihe-in -117.66, 131.56 APE8-dihe-in -80.54, 63.91 APE8-rot-na 31.59 APE67-dihe-in -62.62, -22.15 -50.58, -36.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2177 None None None XRAY 2.1 0.186 0.209 A 291.0 269.0 18 30 25 5 [[510, 783]] 1.0 4pmt Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5I8AA P04629 501 787 796.0 69C:60801 Type1 Inactive DFGin 6.738 14.3896 None -97.16, -113.31 -48.28, 144.89 -102.36, 10.49 289.66, 94.22 178.06, 999.0 in-in in 9.6286 Saltbr-in 3.266 HRD-in -70.07, -53.33 85.54, -20.79 in-out-in SNCioi out-in ActLoopNT-out 17.1271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.82, 123.59 APE9-dihe-in -112.87, 128.48 APE8-dihe-in -77.41, 62.86 APE8-rot-na 29.5 APE67-dihe-in -66.17, -22.6 -48.87, -35.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2452 None None None XRAY 2.33 0.18 0.209 A 296.0 266.0 21 30 26 4 [[510, 783]] 1.0 5i8a Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6IQNA P04629 502 790 796.0 AQ6:60801 Type1 Inactive DFGin 7.14 15.1103 None -103.61, -29.7 -117.2, -70.49 62.55, 999.0 316.84, 95.5 999.0, 999.0 in-out in 9.7917 Saltbr-out 4.8101 HRD-in -72.08, -53.46 85.54, -25.89 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.52, 109.29 APE9-dihe-in -102.41, 128.27 APE8-dihe-in -77.64, 69.03 APE8-rot-na 26.82 APE67-dihe-in -69.77, -22.47 -58.81, -29.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3302 None None None XRAY 2.54 0.228 0.287 A 296.0 271.0 18 30 18 12 [[510, 783]] 1.0 6iqn Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 7XAFA P04629 498 796 796.0 FKT:801 Type1 Inactive DFGin 10.9726 15.5303 None -141.15, 137.13 74.8, 177.08 49.53, -82.17 307.2, 139.07 -1.5, 80.75 in-out in 9.4808 Saltbr-out 3.7007 HRD-out -81.39, 105.98 -86.3, -0.43 out-out-in SNCooi out-in ActLoopNT-out 15.4378 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.83, 144.52 APE9-dihe-in -128.89, 123.51 APE8-dihe-in -76.16, 66.1 APE8-rot-na 29.0 APE67-dihe-in -71.14, -21.57 -60.15, -25.01 APE12-dist-na 15.0229 APE11-dist-na 14.3354 APE10-dist-na 10.4171 APE9-dist-in 7.3626 None None None XRAY 3.001 0.25 0.299 A 299.0 287.0 12 30 30 0 [[510, 783]] 1.0 7xaf Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6J5LA P04629 502 790 796.0 B9C:60801 Type1 Inactive DFGin 6.1274 13.7929 None -112.0, -17.65 -146.4, 142.64 -117.9, -119.21 307.69, 78.13 -102.52, 999.0 in-in in 9.3453 Saltbr-in 3.4221 HRD-out -88.88, 113.33 -93.5, 4.21 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.51, 126.2 APE9-dihe-in -111.04, 133.44 APE8-dihe-in -88.74, 66.42 APE8-rot-na 38.43 APE67-dihe-in -63.3, -23.33 -52.55, -36.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9327 None None None XRAY 2.3 0.224 0.251 A 303.0 278.0 11 30 23 7 [[510, 783]] 1.0 6j5l Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PMEB P04629 499 791 796.0 OOY:802 Type1 Inactive DFGin 8.0413 12.7752 None -108.23, 50.17 -34.62, -93.7 -97.7, 157.35 268.23, 140.64 158.45, -156.12 in-out in 9.6869 Saltbr-out 4.3617 HRD-in -75.61, -49.56 82.71, -16.4 out-out-none SNCoon out-none ActLoopNT-out 15.6778 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.79 APE9-dihe-in -136.64, 129.71 APE8-dihe-in -72.47, 62.28 APE8-rot-na 30.59 APE67-dihe-in -74.1, -16.42 -50.47, -31.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7569 APE9-dist-in 7.0187 None SEP677 SEP677 XRAY 3.0 0.259 0.315 B 311.0 271.0 22 30 25 5 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.3285 15.1025 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.6981 Saltbr-in 3.2532 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4955 None None None XRAY 2.864 0.22 0.277 A 320.0 264.0 32 30 11 19 [[510, 783]] 1.0 9dai Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 7VKOA P04629 502 793 796.0 7GI:60801 Type1 Inactive DFGin 6.3309 13.7935 None -121.29, -23.19 -130.55, 158.61 -131.43, -91.62 300.81, 84.28 -89.58, -178.74 in-out in 9.271 Saltbr-out 4.8438 HRD-out -83.55, 115.94 -93.33, 10.49 out-out-in SNCooi out-in ActLoopNT-out 15.2129 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.01, 135.08 APE9-dihe-in -120.4, 150.84 APE8-dihe-in -84.95, 78.96 APE8-rot-na 37.61 APE67-dihe-in -53.21, -25.59 -47.58, -54.99 APE12-dist-na 10.7383 APE11-dist-na 11.7728 APE10-dist-na 9.7313 APE9-dist-in 6.3483 None None None XRAY 2.9 0.188 0.267 A 326.0 292.0 0 30 30 0 [[510, 783]] 1.0 7vko Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4AOJB P04629 500 791 796.0 V4Z:900 Type1 Inactive DFGin 7.1015 14.487 None -112.8, -14.1 -146.85, 148.75 -118.66, 999.0 304.25, 74.79 999.0, 999.0 in-out in 9.7738 Saltbr-out 3.7833 HRD-in -81.07, -46.03 78.05, -27.65 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.18 APE8-dihe-in -83.87, 63.88 APE8-rot-na 24.55 APE67-dihe-in -64.26, -27.58 -47.61, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2365 None None None XRAY 2.75 0.221 0.242 B 329.0 258.0 34 30 11 19 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6DKGA P04629 500 796 796.0 22L:801,GO7:802 Allosteric,Type2 Inactive DFGout 15.4548 10.8854 BBAminus -129.84, -153.68 -169.97, 108.79 -76.62, -30.73 288.52, 72.75 116.03, 999.0 in-out in 9.8508 Saltbr-out 5.1091 HRD-in -69.9, -49.64 79.4, -12.32 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.62, 109.43 APE9-dihe-in -100.38, 134.76 APE8-dihe-in -83.29, 59.25 APE8-rot-na 32.8 APE67-dihe-in -64.09, -21.64 -42.0, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3571 None None None XRAY 2.53 0.189 0.225 A 320.0 276.0 21 30 21 9 [[510, 783]] 1.0 6dkg Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6DKIA P04629 500 796 796.0 22L:801,GOD:802 Allosteric,Type2 Inactive DFGout 15.6566 10.3394 BBAminus -138.27, -151.87 -172.63, 116.91 -81.37, -9.66 281.96, 77.97 75.28, 999.0 in-out in 9.8948 Saltbr-out 4.9127 HRD-in -65.87, -50.46 77.43, -14.55 out-out-in SNCooi out-in ActLoopNT-out 16.6148 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.45, 122.12 APE9-dihe-in -117.82, 128.28 APE8-dihe-in -76.01, 65.16 APE8-rot-na 30.62 APE67-dihe-in -68.36, -18.63 -49.98, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.307 None None None XRAY 2.11 0.186 0.227 A 320.0 279.0 18 30 24 6 [[510, 783]] 1.0 6dki Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6D1ZA P04629 483 796 796.0 FQD:801,FQM:803 Allosteric,Type3 Inactive DFGout 12.5668 7.3661 BBAminus 167.82, 150.89 -150.57, 163.47 -100.59, 23.19 306.23, 116.03 65.85, 23.26 in-out in 9.8538 Saltbr-out 6.197 HRD-in -66.06, -47.82 80.23, -21.06 out-out-in SNCooi out-in ActLoopNT-out 15.3022 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.79, 107.46 APE9-dihe-in -108.68, 135.71 APE8-dihe-in -79.15, 66.52 APE8-rot-na 33.74 APE67-dihe-in -68.05, -19.94 -54.02, -36.77 APE12-dist-na 999.0 APE11-dist-na 14.491 APE10-dist-na 10.8188 APE9-dist-in 7.2531 None None None XRAY 1.87 0.18 0.21 A 320.0 290.0 16 30 26 4 [[510, 783]] 1.0 6d1z Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 7VKMA P04629 502 795 796.0 No_ligand No_ligand Inactive DFGout 12.3226 7.4321 BBAminus 176.27, 165.41 -156.55, 175.73 -110.4, 8.5 305.75, 118.24 88.56, 16.82 in-out in 9.5677 Saltbr-out 4.9155 HRD-in -72.61, -55.29 84.51, -23.12 out-out-in SNCooi out-in ActLoopNT-out 15.6614 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.68, 125.36 APE9-dihe-in -117.44, 136.53 APE8-dihe-in -89.28, 75.32 APE8-rot-na 30.03 APE67-dihe-in -68.93, -24.54 -65.78, -30.21 APE12-dist-na 14.2495 APE11-dist-na 15.511 APE10-dist-na 10.8702 APE9-dist-in 7.2065 G595R None None XRAY 2.55 0.202 0.257 A 326.0 294.0 0 30 30 0 [[510, 783]] 1.0 7vkm Homo sapiens TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4PMPA P04629 501 787 796.0 31W:60801 Type1 Inactive DFGout 15.4862 10.5504 BBAminus -133.03, -157.37 -173.03, 103.22 -69.9, -32.34 288.02, 70.73 77.22, -47.74 in-out in 9.5683 Saltbr-out 4.6471 HRD-in -67.48, -51.34 82.08, -14.32 out-out-in SNCooi out-in ActLoopNT-out 15.7318 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.87, 121.14 APE9-dihe-in -118.75, 136.28 APE8-dihe-in -80.92, 64.59 APE8-rot-na 34.05 APE67-dihe-in -64.12, -19.76 -49.55, -38.41 APE12-dist-na 999.0 APE11-dist-na 13.9146 APE10-dist-na 9.7347 APE9-dist-in 7.1901 None None None XRAY 1.8 0.166 0.185 A 291.0 276.0 11 30 27 3 [[510, 783]] 1.0 4pmp Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.7078 6.5827 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.4475 Saltbr-out 5.8508 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.8006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.7485 APE11-dist-na 15.1996 APE10-dist-na 10.6807 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324.0 303.0 10 30 30 0 [[510, 783]] 1.0 5h3q Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4PMMA P04629 501 787 796.0 31V:60801 Type2 Inactive DFGout 12.1455 10.95 BBAminus -133.43, -162.51 -156.69, 94.05 -92.35, -31.82 309.48, 143.39 59.02, -8.13 in-out in 9.2861 Saltbr-out 4.7596 HRD-in -72.63, -53.5 82.36, -15.27 out-out-in SNCooi out-in ActLoopNT-out 16.0948 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.51, 115.08 APE9-dihe-in -105.75, 129.0 APE8-dihe-in -80.23, 63.87 APE8-rot-na 30.48 APE67-dihe-in -66.31, -17.94 -46.68, -40.06 APE12-dist-na 13.7863 APE11-dist-na 15.797 APE10-dist-na 10.7596 APE9-dist-in 7.1451 None None None XRAY 2.0 0.166 0.199 A 291.0 281.0 6 30 30 0 [[510, 783]] 1.0 4pmm Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5JFSA P04629 502 793 796.0 6K0:64000 Type2 Inactive DFGout 12.5274 10.9828 BBAminus -135.78, -160.84 -157.76, 107.91 -107.26, 3.47 322.34, 129.58 106.13, 999.0 in-in in 9.8096 Saltbr-in 2.8877 HRD-in -71.87, -49.52 79.25, -12.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.58 APE8-dihe-in -83.43, 60.43 APE8-rot-na 33.02 APE67-dihe-in -63.9, -20.6 -49.99, -40.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5654 None None None XRAY 2.07 0.171 0.191 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfs Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5JFVA P04629 502 793 796.0 6K1:64000 Type2 Inactive DFGout 12.6383 11.028 BBAminus -141.43, -159.86 -155.63, 106.71 -102.51, 5.29 321.04, 131.31 88.83, 999.0 out-out out 10.053 Saltbr-out 3.8424 HRD-in -71.26, -49.89 78.63, -12.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.24 APE8-dihe-in -81.16, 59.69 APE8-rot-na 33.1 APE67-dihe-in -63.0, -20.76 -49.39, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5332 None None None XRAY 1.59 0.173 0.192 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfv Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5JFWA P04629 502 793 796.0 6K2:64000 Type2 Inactive DFGout 12.6588 11.1947 BBAminus -133.87, -158.13 -156.47, 107.62 -101.73, 2.97 321.78, 129.01 71.48, 999.0 out-out out 10.1959 Saltbr-out 8.1097 HRD-in -70.93, -50.56 80.08, -11.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.64 APE8-dihe-in -79.87, 59.55 APE8-rot-na 31.09 APE67-dihe-in -62.34, -22.4 -47.37, -43.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5174 None None None XRAY 1.52 0.18 0.209 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfw Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5JFXA P04629 502 793 796.0 6K4:64000 Type2 Inactive DFGout 12.7478 11.0402 BBAminus -133.96, -162.47 -154.94, 107.94 -100.19, 17.72 319.82, 130.69 65.97, 999.0 out-in out 10.1166 Saltbr-in 3.4793 HRD-in -70.26, -49.25 76.75, -14.14 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.45 APE8-dihe-in -81.06, 57.38 APE8-rot-na 33.47 APE67-dihe-in -62.32, -20.75 -46.26, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6498 None None None XRAY 1.63 0.203 0.232 A 308.0 264.0 28 30 12 18 [[510, 783]] 1.0 5jfx Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6DKWA P04629 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.7974 11.1466 BBAminus -132.36, -152.04 -163.87, 118.82 -86.57, 0.12 282.19, 82.2 87.26, 999.0 out-out out 10.036 Saltbr-out 7.7065 HRD-in -70.19, -47.29 72.43, -13.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.7 APE8-dihe-in -77.96, 56.47 APE8-rot-na 32.78 APE67-dihe-in -69.34, -24.62 -48.56, -36.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4575 None None None XRAY 2.91 0.233 0.262 A 308.0 271.0 21 30 12 18 [[510, 783]] 1.0 6dkw Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6DKWB P04629 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.3125 11.6643 BBAminus -137.72, -157.97 -167.56, 133.61 -110.92, -23.72 305.39, 77.76 119.48, 999.0 in-out in 9.8059 Saltbr-out 7.9525 HRD-in -71.64, -50.67 77.06, -19.15 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.56, 120.27 APE9-dihe-in -83.42, 115.11 APE8-dihe-in -79.02, 56.72 APE8-rot-na 32.67 APE67-dihe-in -66.06, -29.18 -49.12, -39.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8914 None None None XRAY 2.91 0.233 0.262 B 308.0 263.0 29 30 14 16 [[510, 783]] 1.0 6dkw Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PL2A P04629 499 795 796.0 OOM:801 Type2 Inactive DFGout 12.6124 11.7331 BBAminus -133.35, -162.35 -156.24, 113.82 -105.83, 45.09 316.55, 125.06 63.21, -157.53 in-out in 8.738 Saltbr-out 4.3488 HRD-in -67.21, -55.46 83.15, -23.62 out-out-in SNCooi out-in ActLoopNT-out 18.1791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.48, 132.06 APE9-dihe-in -120.18, 125.99 APE8-dihe-in -79.18, 69.41 APE8-rot-na 32.0 APE67-dihe-in -66.97, -17.29 -57.88, -39.56 APE12-dist-na 10.5006 APE11-dist-na 10.402 APE10-dist-na 5.7304 APE9-dist-in 7.3003 None SEP677 SEP677 XRAY 2.59 0.202 0.274 A 311.0 297.0 0 30 30 0 [[510, 783]] 1.0 6pl2 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 7XBIA P04629 497 795 796.0 CVY:801 Type2 Inactive DFGout 14.1066 10.7958 BBAminus -137.82, -164.37 -150.04, 97.3 -71.59, -9.66 278.32, 66.5 74.67, 31.7 in-out in 9.747 Saltbr-out 4.3181 HRD-in -82.22, -63.27 93.82, -12.28 out-out-in SNCooi out-in ActLoopNT-out 18.4232 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.41, 123.03 APE9-dihe-in -113.59, 129.96 APE8-dihe-in -80.4, 65.23 APE8-rot-na 30.24 APE67-dihe-in -62.07, -20.59 -54.97, -38.49 APE12-dist-na 10.5456 APE11-dist-na 11.0821 APE10-dist-na 6.2426 APE9-dist-in 7.2058 None None None XRAY 2.16 0.194 0.246 A 311.0 299.0 0 30 30 0 [[510, 783]] 1.0 7xbi Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 8J5XA P04629 500 795 796.0 A4U:801 Type2 Inactive DFGout 13.0357 10.3688 BBAminus -130.91, -158.27 -162.66, 108.46 -93.68, 5.06 291.9, 93.65 78.16, -167.64 in-in in 8.8892 Saltbr-in 2.6102 HRD-in -70.53, -55.33 83.0, -11.79 in-out-in SNCioi out-in ActLoopNT-out 18.3297 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.89, 140.84 APE9-dihe-in -129.21, 130.11 APE8-dihe-in -79.69, 64.42 APE8-rot-na 33.0 APE67-dihe-in -65.79, -20.2 -56.52, -34.65 APE12-dist-na 13.2974 APE11-dist-na 8.8947 APE10-dist-na 6.0299 APE9-dist-in 7.2178 G595R None None XRAY 2.092 0.184 0.22 A 299.0 296.0 0 30 30 0 [[510, 783]] 1.0 8j5x Homo sapiens TYR_NTRK1_HUMAN TYR 9.7e-99 335.8 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PL4A P04629 485 795 796.0 OO7:801 Type3 Inactive DFGout 12.3312 6.751 BBAminus 163.32, 156.14 -161.4, 166.2 -103.41, 14.03 294.82, 105.0 75.38, 27.87 in-out in 9.5479 Saltbr-out 6.9473 HRD-in -67.83, -53.77 81.67, -11.19 out-out-in SNCooi out-in ActLoopNT-out 15.6773 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.06, 119.89 APE9-dihe-in -108.16, 133.15 APE8-dihe-in -81.07, 64.06 APE8-rot-na 35.11 APE67-dihe-in -63.69, -22.36 -54.01, -37.98 APE12-dist-na 13.7742 APE11-dist-na 15.0652 APE10-dist-na 10.8029 APE9-dist-in 7.2586 None SEP677 SEP677 XRAY 2.06 0.202 0.239 A 311.0 299.0 3 30 30 0 [[510, 783]] 1.0 6pl4 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6D20A P04629 482 796 796.0 FQD:801,FQG:802 Allosteric,Type3 Inactive DFGout 12.1211 7.6823 None 160.41, 153.19 -151.74, 163.05 -104.33, 22.77 307.7, 135.7 70.27, 21.28 out-out out 10.0112 Saltbr-out 4.832 HRD-in -65.64, -51.3 81.74, -20.54 out-out-in SNCooi out-in ActLoopNT-out 15.2703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.06, 110.16 APE9-dihe-in -105.1, 135.52 APE8-dihe-in -82.75, 65.28 APE8-rot-na 34.64 APE67-dihe-in -60.75, -21.14 -48.61, -41.93 APE12-dist-na 999.0 APE11-dist-na 15.3801 APE10-dist-na 10.9754 APE9-dist-in 7.2207 None None None XRAY 1.94 0.172 0.207 A 320.0 296.0 13 30 28 2 [[510, 783]] 1.0 6d20 Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4F0IA P04629 501 790 796.0 No_ligand No_ligand Inactive DFGout 12.7244 6.541 None 168.4, 147.46 -150.91, -178.97 -114.84, 17.84 296.33, 102.98 77.14, 17.47 out-out out 10.0716 Saltbr-out 3.7832 HRD-in -70.62, -54.37 86.42, -21.28 out-out-in SNCooi out-in ActLoopNT-out 15.4708 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.87, 117.07 APE9-dihe-in -123.33, 147.3 APE8-dihe-in -80.93, 68.13 APE8-rot-na 33.21 APE67-dihe-in -63.68, -22.55 -54.54, -38.97 APE12-dist-na 18.8871 APE11-dist-na 14.6754 APE10-dist-na 10.9186 APE9-dist-in 7.2309 None None None XRAY 2.302 0.185 0.241 A 300.0 284.0 6 30 30 0 [[510, 783]] 1.0 4f0i Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4F0IB P04629 501 794 796.0 No_ligand No_ligand Inactive DFGout 12.5434 7.0115 None 166.76, 148.15 -155.18, 178.64 -114.64, 15.88 300.05, 104.73 73.51, 23.99 in-out in 9.5461 Saltbr-out 3.6132 HRD-in -74.85, -50.62 80.22, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.4992 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.15, 119.22 APE9-dihe-in -115.7, 131.68 APE8-dihe-in -79.13, 66.63 APE8-rot-na 32.83 APE67-dihe-in -65.29, -20.15 -62.09, -33.78 APE12-dist-na 15.6478 APE11-dist-na 15.2052 APE10-dist-na 10.6707 APE9-dist-in 7.475 None None None XRAY 2.302 0.185 0.241 B 300.0 294.0 0 30 30 0 [[510, 783]] 1.0 4f0i Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4GT5A P04629 498 793 796.0 No_ligand No_ligand Inactive DFGout 12.6043 7.3471 None 159.19, 156.78 -162.75, 171.4 -109.98, 15.11 307.11, 107.92 73.58, 34.63 in-none in 9.7567 Saltbr-none 999.0 HRD-in -59.3, -59.24 86.11, -5.83 none-out-in SNCnoi out-in ActLoopNT-out 15.7975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.6, 126.13 APE9-dihe-in -108.71, 129.99 APE8-dihe-in -77.33, 65.58 APE8-rot-na 28.73 APE67-dihe-in -65.65, -17.34 -57.96, -37.68 APE12-dist-na 15.1467 APE11-dist-na 15.3699 APE10-dist-na 11.2291 APE9-dist-in 7.4443 None None None XRAY 2.398 0.204 0.248 A 306.0 290.0 6 30 30 0 [[510, 783]] 1.0 4gt5 Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6D22A P04629 502 794 796.0 No_ligand No_ligand Inactive DFGout 12.606 7.1432 None 175.88, 158.7 -166.39, 174.44 -112.95, 15.95 304.35, 111.16 86.04, 4.07 in-out in 9.6133 Saltbr-out 3.848 HRD-in -74.57, -54.54 85.84, -16.79 out-out-in SNCooi out-in ActLoopNT-out 15.8411 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.68, 117.35 APE9-dihe-in -107.64, 132.88 APE8-dihe-in -74.3, 62.56 APE8-rot-na 38.38 APE67-dihe-in -63.87, -17.11 -48.79, -48.38 APE12-dist-na 13.8949 APE11-dist-na 15.2645 APE10-dist-na 10.9497 APE9-dist-in 7.5774 None None None XRAY 2.46 0.178 0.236 A 307.0 293.0 0 30 30 0 [[510, 783]] 1.0 6d22 Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6DKBA P04629 501 796 796.0 FKY:4000 Type1 Inactive DFGout 15.3321 10.7475 None -132.31, -154.04 -173.63, 117.2 -89.02, -138.07 293.55, 87.71 -145.33, 999.0 out-in out 10.0153 Saltbr-in 3.3428 HRD-in -63.64, -46.04 75.89, -18.83 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 136.46 APE9-dihe-in -131.13, 141.89 APE8-dihe-in -81.0, 68.63 APE8-rot-na 33.49 APE67-dihe-in -61.76, -21.1 -51.01, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2727 None None None XRAY 2.68 0.217 0.245 A 320.0 272.0 24 30 19 11 [[510, 783]] 1.0 6dkb Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMOA P04629 500 796 796.0 6UM:60901 Type1 Inactive DFGout 12.3188 11.3736 None -138.6, -165.07 -158.74, 98.32 -111.51, -171.02 340.4, 114.97 156.89, 999.0 out-out out 10.6308 Saltbr-out 6.3163 HRD-in -66.47, -58.38 85.91, -20.7 out-out-in SNCooi out-in ActLoopNT-out 17.2212 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.17, 145.62 APE9-dihe-in -124.84, 130.96 APE8-dihe-in -87.13, 68.95 APE8-rot-na 25.74 APE67-dihe-in -56.92, -24.53 -50.66, -48.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1614 None None None XRAY 2.67 0.196 0.243 A 329.0 290.0 7 30 28 2 [[510, 783]] 1.0 5kmo Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4PMSA P04629 501 787 796.0 31X:60801 Type1.5_Back Inactive DFGout 12.026 11.6074 None -132.53, -155.25 -159.75, 97.5 -105.99, 141.7 318.1, 112.95 -75.26, -27.15 in-out in 9.4706 Saltbr-out 6.4616 HRD-in -62.95, -59.22 88.04, -25.42 out-out-in SNCooi out-in ActLoopNT-out 15.9197 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 110.83 APE9-dihe-in -104.11, 139.32 APE8-dihe-in -84.02, 66.3 APE8-rot-na 28.87 APE67-dihe-in -67.29, -19.63 -45.69, -39.43 APE12-dist-na 17.3848 APE11-dist-na 17.1424 APE10-dist-na 12.4834 APE9-dist-in 7.2332 None None None XRAY 2.8 0.168 0.24 A 291.0 279.0 8 30 28 2 [[510, 783]] 1.0 4pms Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 8J5WA P04629 485 795 796.0 A4U:801 Type2 Inactive DFGout 14.1063 9.9042 None -124.93, -156.11 -165.36, 86.03 -59.52, 147.81 290.47, 86.44 107.07, -85.27 in-out in 9.5724 Saltbr-out 6.0721 HRD-out -97.68, 106.96 -81.54, 7.53 out-out-in SNCooi out-in ActLoopNT-out 16.096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.59, 129.11 APE9-dihe-in -117.85, 126.3 APE8-dihe-in -74.82, 63.31 APE8-rot-na 31.0 APE67-dihe-in -67.5, -17.44 -56.64, -33.03 APE12-dist-na 15.4415 APE11-dist-na 16.0691 APE10-dist-na 11.3999 APE9-dist-in 7.0397 F589L None None XRAY 2.28 0.222 0.266 A 313.0 298.0 4 30 30 0 [[510, 783]] 1.0 8j5w Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 340.9 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 8J61A P04629 499 795 796.0 A0X:801 Type2 Inactive DFGout 13.2302 11.1552 None -134.57, -179.08 -139.19, 96.75 -83.33, 178.03 307.14, 171.93 171.37, -120.57 out-out out 10.1094 Saltbr-out 6.4555 HRD-in -80.6, -37.38 66.53, -21.87 out-out-in SNCooi out-in ActLoopNT-out 15.5742 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -141.71, 130.82 APE9-dihe-in -115.65, 127.68 APE8-dihe-in -74.28, 70.21 APE8-rot-na 29.28 APE67-dihe-in -73.67, -7.76 -58.39, -28.44 APE12-dist-na 16.7752 APE11-dist-na 15.1622 APE10-dist-na 11.5782 APE9-dist-in 6.9973 None None None XRAY 3.051 0.209 0.255 A 299.0 291.0 6 30 30 0 [[510, 783]] 1.0 8j61 Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 8J63A P04629 500 796 796.0 A6X:801 Type2 Inactive DFGout 13.7582 10.3144 None -148.15, -172.21 -147.6, 96.08 -75.43, 162.83 293.22, 106.5 105.33, -112.14 in-out in 9.8194 Saltbr-out 4.2447 HRD-in -78.37, -44.48 66.44, -4.46 out-out-in SNCooi out-in ActLoopNT-out 15.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.3, 149.87 APE9-dihe-in -128.22, 125.62 APE8-dihe-in -76.56, 58.46 APE8-rot-na 30.42 APE67-dihe-in -72.95, -14.47 -58.85, -23.58 APE12-dist-na 17.2827 APE11-dist-na 16.1057 APE10-dist-na 11.8492 APE9-dist-in 7.2566 None None None XRAY 3.001 0.233 0.289 A 299.0 291.0 6 30 30 0 [[510, 783]] 1.0 8j63 Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5WR7A P04629 489 792 796.0 RCH:801 Type2 Inactive DFGout 14.6633 8.4308 None -131.73, -148.47 -166.21, 161.63 -141.28, 117.22 276.93, 88.17 -99.45, -3.58 out-out out 10.1911 Saltbr-out 7.4254 HRD-in -69.6, -49.89 70.97, 2.48 out-out-in SNCooi out-in ActLoopNT-out 18.1253 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.65, 116.34 APE9-dihe-in -122.66, 128.76 APE8-dihe-in -78.54, 68.52 APE8-rot-na 32.36 APE67-dihe-in -68.82, -19.66 -50.73, -45.45 APE12-dist-na 999.0 APE11-dist-na 14.9273 APE10-dist-na 10.0895 APE9-dist-in 7.0416 None SEP677 SEP677 XRAY 2.76 0.208 0.234 A 304.0 302.0 2 30 28 2 [[510, 783]] 1.0 5wr7 Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PL1A P04629 500 795 796.0 OOJ:801 Type2 Inactive DFGout 12.2018 11.5453 None -140.12, -163.59 -151.72, 95.42 -94.74, 114.97 323.02, 137.75 -51.78, -31.38 in-out in 9.5369 Saltbr-out 4.2536 HRD-in -65.5, -55.98 80.9, -7.13 out-out-in SNCooi out-in ActLoopNT-out 16.0161 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.78, 119.43 APE9-dihe-in -106.09, 130.79 APE8-dihe-in -83.67, 66.03 APE8-rot-na 34.24 APE67-dihe-in -63.93, -22.81 -49.57, -43.95 APE12-dist-na 999.0 APE11-dist-na 15.2277 APE10-dist-na 10.758 APE9-dist-in 7.134 None SEP677 SEP677 XRAY 2.03 0.22 0.26 A 311.0 290.0 6 30 27 3 [[510, 783]] 1.0 6pl1 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PL3A P04629 500 795 796.0 OOD:801 Type2 Inactive DFGout 11.5644 10.9099 None -143.28, -158.28 -155.92, 104.62 -110.35, 130.24 309.4, 131.25 -70.56, -23.22 in-out in 9.2687 Saltbr-out 3.683 HRD-in -79.21, -48.25 72.7, -2.08 out-out-in SNCooi out-in ActLoopNT-out 16.4738 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.4, 114.8 APE9-dihe-in -102.82, 125.91 APE8-dihe-in -81.39, 70.95 APE8-rot-na 32.5 APE67-dihe-in -65.12, -18.02 -56.45, -36.14 APE12-dist-na 15.256 APE11-dist-na 16.2849 APE10-dist-na 11.683 APE9-dist-in 7.2155 None None None XRAY 3.0 0.211 0.272 A 311.0 291.0 5 30 30 0 [[510, 783]] 1.0 6pl3 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PMAA P04629 500 795 796.0 OQS:801 Type2 Inactive DFGout 12.1218 11.2768 None -135.79, -172.95 -145.14, 102.3 -103.72, 124.51 321.1, 137.33 -54.09, -40.43 in-in in 9.0466 Saltbr-in 2.5914 HRD-in -75.81, -50.56 78.93, -17.98 in-out-in SNCioi out-in ActLoopNT-out 16.0904 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -134.69, 117.23 APE9-dihe-in -107.06, 120.83 APE8-dihe-in -77.63, 65.04 APE8-rot-na 27.44 APE67-dihe-in -72.95, -15.51 -57.1, -33.54 APE12-dist-na 15.9114 APE11-dist-na 15.6675 APE10-dist-na 10.9989 APE9-dist-in 7.2636 None SEP677 SEP677 XRAY 2.53 0.209 0.266 A 311.0 290.0 6 30 30 0 [[510, 783]] 1.0 6pma Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PMBA P04629 500 795 796.0 OQM:801 Type2 Inactive DFGout 11.6598 11.6719 None -132.37, -159.76 -148.31, 103.43 -105.33, 151.54 318.17, 135.0 -87.93, -24.35 in-in in 9.1747 Saltbr-in 3.4604 HRD-in -70.6, -56.1 77.89, -14.23 in-out-in SNCioi out-in ActLoopNT-out 16.0755 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.62, 125.62 APE9-dihe-in -118.02, 123.95 APE8-dihe-in -78.96, 65.2 APE8-rot-na 32.2 APE67-dihe-in -67.87, -21.55 -67.55, -29.76 APE12-dist-na 15.6492 APE11-dist-na 16.5776 APE10-dist-na 11.6952 APE9-dist-in 7.1864 None None None XRAY 2.81 0.219 0.282 A 311.0 288.0 8 30 30 0 [[510, 783]] 1.0 6pmb Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PMCA P04629 500 795 796.0 OQJ:801 Type2 Inactive DFGout 11.8075 11.813 None -132.04, -168.64 -145.63, 90.01 -97.69, 142.15 324.37, 130.77 -66.35, -36.3 in-in in 9.6514 Saltbr-in 3.5266 HRD-in -82.16, -55.48 89.25, -24.57 in-out-in SNCioi out-in ActLoopNT-out 15.9744 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.7, 118.63 APE9-dihe-in -108.33, 130.52 APE8-dihe-in -80.54, 62.41 APE8-rot-na 37.39 APE67-dihe-in -54.69, -23.0 -49.98, -41.68 APE12-dist-na 14.1544 APE11-dist-na 15.6807 APE10-dist-na 11.2356 APE9-dist-in 7.2264 None SEP677 SEP677 XRAY 2.19 0.25 0.298 A 311.0 289.0 7 30 30 0 [[510, 783]] 1.0 6pmc Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6NSPA P04629 500 795 796.0 L0P:801 Type3 Inactive DFGout 12.3408 6.9177 None 147.69, 153.73 -147.15, -178.06 -113.86, 11.77 292.26, 110.9 67.54, 37.24 in-out in 9.5059 Saltbr-out 9.102 HRD-in -80.74, -60.67 84.66, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.6895 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -135.01, 112.02 APE9-dihe-in -104.87, 129.45 APE8-dihe-in -77.35, 65.98 APE8-rot-na 35.66 APE67-dihe-in -61.95, -17.33 -58.27, -39.42 APE12-dist-na 13.388 APE11-dist-na 15.0547 APE10-dist-na 10.6609 APE9-dist-in 7.3709 None None None XRAY 2.31 0.192 0.255 A 297.0 293.0 3 30 30 0 [[510, 783]] 1.0 6nsp Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6NPTA P04629 491 795 796.0 KWY:801 Type3 Inactive DFGout 12.4381 7.5007 None 158.18, 155.8 -152.05, 169.87 -107.1, 19.78 311.07, 121.3 72.87, 27.1 out-out out 10.0081 Saltbr-out 5.2384 HRD-in -70.4, -52.75 80.08, -14.8 out-out-in SNCooi out-in ActLoopNT-out 15.5916 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.83, 113.75 APE9-dihe-in -105.63, 131.16 APE8-dihe-in -80.28, 65.31 APE8-rot-na 34.86 APE67-dihe-in -61.58, -17.65 -56.43, -41.31 APE12-dist-na 14.4263 APE11-dist-na 15.1866 APE10-dist-na 10.6476 APE9-dist-in 7.2622 None SEP677 SEP677 XRAY 2.19 0.227 0.276 A 305.0 288.0 10 30 30 0 [[510, 783]] 1.0 6npt Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6NSSA P04629 485 795 796.0 L0M:801 Type3 Inactive DFGout 11.8151 7.0253 None 168.65, 153.78 -158.36, 171.84 -109.19, 24.3 297.57, 118.56 67.82, 28.96 in-out in 9.528 Saltbr-out 5.6657 HRD-in -90.15, -59.03 81.79, -5.07 out-out-in SNCooi out-in ActLoopNT-out 16.0664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.54, 111.04 APE9-dihe-in -105.46, 130.52 APE8-dihe-in -80.81, 65.09 APE8-rot-na 33.3 APE67-dihe-in -66.94, -20.44 -58.3, -34.71 APE12-dist-na 13.0683 APE11-dist-na 15.0175 APE10-dist-na 10.6868 APE9-dist-in 7.4489 None None None XRAY 1.97 0.184 0.218 A 311.0 303.0 3 30 30 0 [[510, 783]] 1.0 6nss Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6D1YA P04629 481 796 796.0 FQJ:801 Type3 Inactive DFGout 12.6733 6.8555 None 169.8, 145.64 -149.42, -179.74 -114.54, 6.91 301.35, 101.16 76.21, 25.01 out-out out 10.0516 Saltbr-out 5.4416 HRD-in -65.07, -51.13 81.32, -20.97 out-out-in SNCooi out-in ActLoopNT-out 15.4706 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.27, 120.93 APE9-dihe-in -115.22, 138.24 APE8-dihe-in -78.51, 63.15 APE8-rot-na 29.74 APE67-dihe-in -66.08, -21.72 -48.21, -36.42 APE12-dist-na 999.0 APE11-dist-na 14.923 APE10-dist-na 10.7086 APE9-dist-in 7.2537 None None None XRAY 1.93 0.179 0.224 A 320.0 300.0 16 30 26 4 [[510, 783]] 1.0 6d1y Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMIA P04629 486 796 796.0 6UE:901 Type3 Inactive DFGout 12.1021 7.2926 None 161.69, 152.83 -154.44, 168.25 -105.96, 25.99 305.3, 125.58 65.11, 30.06 in-out in 9.4863 Saltbr-out 6.201 HRD-in -70.33, -55.53 75.77, -9.09 out-out-in SNCooi out-in ActLoopNT-out 15.7575 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.77, 111.89 APE9-dihe-in -104.52, 130.31 APE8-dihe-in -84.87, 65.08 APE8-rot-na 32.16 APE67-dihe-in -62.84, -22.31 -53.23, -38.24 APE12-dist-na 14.0032 APE11-dist-na 15.6542 APE10-dist-na 10.9157 APE9-dist-in 7.5288 None None None XRAY 1.87 0.21 0.247 A 329.0 300.0 6 30 30 0 [[510, 783]] 1.0 5kmi Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.6023 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.7145 Saltbr-in 2.7723 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.1073 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.0163 APE11-dist-na 15.494 APE10-dist-na 11.0956 APE9-dist-in 7.6003 None None None XRAY 2.04 0.196 0.226 A 329.0 300.0 6 30 30 0 [[510, 783]] 1.0 5kmj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMKA P04629 484 796 796.0 6UG:60901 Type3 Inactive DFGout 12.3673 7.4438 None 155.23, 152.12 -152.95, 175.79 -116.52, 20.57 308.16, 114.44 75.73, 21.77 in-out in 9.7632 Saltbr-out 6.3973 HRD-in -59.42, -51.85 75.91, -16.02 out-out-in SNCooi out-in ActLoopNT-out 15.4709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.53, 119.76 APE9-dihe-in -107.42, 137.31 APE8-dihe-in -83.03, 63.78 APE8-rot-na 29.2 APE67-dihe-in -62.44, -17.14 -49.56, -42.83 APE12-dist-na 14.0289 APE11-dist-na 15.4162 APE10-dist-na 11.1025 APE9-dist-in 7.2499 None None None XRAY 2.24 0.227 0.281 A 329.0 302.0 5 30 30 0 [[510, 783]] 1.0 5kmk Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMMA P04629 484 796 796.0 6UJ:60901 Type3 Inactive DFGout 12.3683 7.1842 None 157.73, 155.5 -160.68, 165.48 -107.15, 26.91 307.0, 120.61 71.24, 15.54 in-out in 9.463 Saltbr-out 5.1138 HRD-in -61.78, -57.27 78.61, -13.21 out-out-in SNCooi out-in ActLoopNT-out 15.6626 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.76, 118.16 APE9-dihe-in -103.64, 132.25 APE8-dihe-in -82.99, 66.28 APE8-rot-na 32.09 APE67-dihe-in -66.37, -19.35 -53.37, -35.26 APE12-dist-na 13.5484 APE11-dist-na 15.6333 APE10-dist-na 11.2071 APE9-dist-in 7.4278 None None None XRAY 2.12 0.216 0.264 A 329.0 300.0 5 30 30 0 [[510, 783]] 1.0 5kmm Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMLA P04629 474 796 796.0 6UH:60901 Type3 Inactive DFGout 12.3981 7.2825 None 158.81, 154.45 -158.96, 169.19 -111.19, 29.55 308.68, 112.5 65.84, 21.76 in-out in 9.9569 Saltbr-out 5.2259 HRD-out -95.27, 113.75 -82.3, 1.42 out-out-in SNCooi out-in ActLoopNT-out 16.0097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.36, 117.18 APE9-dihe-in -101.68, 134.53 APE8-dihe-in -83.65, 62.57 APE8-rot-na 32.66 APE67-dihe-in -60.72, -23.67 -48.68, -40.28 APE12-dist-na 14.5118 APE11-dist-na 15.2496 APE10-dist-na 11.0243 APE9-dist-in 7.223 None None None XRAY 2.01 0.204 0.232 A 330.0 296.0 8 30 30 0 [[510, 783]] 1.0 5kml Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 5KMNA P04629 474 796 796.0 6UK:60901 Type3 Inactive DFGout 12.5503 7.5403 None 154.23, 154.5 -157.96, 168.93 -109.62, 31.32 313.55, 117.07 68.77, 19.82 in-out in 9.8895 Saltbr-out 4.9957 HRD-out -100.52, 112.12 -80.72, -0.22 out-out-in SNCooi out-in ActLoopNT-out 16.1678 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.74, 114.86 APE9-dihe-in -100.75, 133.2 APE8-dihe-in -82.26, 61.08 APE8-rot-na 30.54 APE67-dihe-in -63.96, -19.55 -48.16, -39.69 APE12-dist-na 14.5609 APE11-dist-na 15.3668 APE10-dist-na 11.1626 APE9-dist-in 7.3231 None None None XRAY 2.14 0.195 0.222 A 330.0 296.0 8 30 30 0 [[510, 783]] 1.0 5kmn Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 4YPSA P04629 502 790 796.0 4F6:60801 Type1 Inactive None 999.0 999.0 None -112.08, -158.35 4.87, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.117 Saltbr-out 9.1251 HRD-out -86.73, 118.76 -94.8, 9.98 out-out-in SNCooi out-in ActLoopNT-out 17.7427 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.0, 118.89 APE9-dihe-in -107.28, 139.4 APE8-dihe-in -81.62, 61.84 APE8-rot-na 34.18 APE67-dihe-in -64.91, -18.75 -58.48, -35.44 APE12-dist-na 999.0 APE11-dist-na 14.6064 APE10-dist-na 10.3213 APE9-dist-in 7.2262 None None None XRAY 2.101 0.203 0.257 A 303.0 275.0 14 30 25 5 [[510, 783]] 1.0 4yps Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PMEA P04629 500 788 796.0 OOY:802 Type1 Inactive None 11.2737 14.866 None -103.64, 63.03 -6.61, -101.22 -108.6, -79.47 316.94, 83.99 80.48, -131.89 in-out in 9.6502 Saltbr-out 4.1971 HRD-in -82.82, -49.18 87.37, -21.9 out-out-in SNCooi out-in ActLoopNT-out 15.6261 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.61, 116.38 APE9-dihe-in -119.8, 127.41 APE8-dihe-in -74.42, 64.21 APE8-rot-na 33.13 APE67-dihe-in -65.79, -8.94 -53.59, -37.65 APE12-dist-na 999.0 APE11-dist-na 14.3493 APE10-dist-na 10.4008 APE9-dist-in 7.1239 None SEP677 SEP677 XRAY 3.0 0.259 0.315 A 311.0 268.0 21 30 27 3 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1 NTRK1_HUMAN 6PMEC P04629 500 790 796.0 OOY:802 Type1 Inactive None 11.5194 15.0044 None -105.17, 39.93 27.01, -158.9 -47.91, -126.82 299.14, 109.98 111.56, -123.09 in-out in 9.6725 Saltbr-out 4.9611 HRD-in -71.5, -57.03 89.79, -15.29 out-out-in SNCooi out-in ActLoopNT-out 15.6199 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.99, 111.57 APE9-dihe-in -114.5, 136.16 APE8-dihe-in -76.15, 63.17 APE8-rot-na 31.13 APE67-dihe-in -65.29, -26.47 -45.99, -41.18 APE12-dist-na 16.0835 APE11-dist-na 14.6809 APE10-dist-na 10.6659 APE9-dist-in 6.9642 None SEP677 SEP677 XRAY 3.0 0.259 0.315 C 311.0 274.0 17 30 28 2 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor

TYR_NTRK1 (High affinity nerve growth factor receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name