TYR_NTRK1 (High affinity nerve growth factor receptor)

Total number of chains: 64
Active chains: 2
Family: TYR
Uniprot: NTRK1_HUMAN
Kinase Domain Residues: 510 - 783
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 27 42.2% 4F0IB
DFGout BBAminus 17 26.6% 8J5XA
DFGin None 9 14.1% 7VKOA
DFGin ABAminus 6 9.4% 7VKNA
None None 3 4.7% 4YPSA
DFGin BLAminus 2 3.1% AF-P04629-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P04629-K1A 502 791 796.0 No_ligand No_ligand Active DFGin 7.164 14.372 BLAminus -126.4, -168.05 48.95, 78.27 -90.55, 12.64 289.56, 90.19 -61.03, -31.73 in-in in 8.978 Saltbr-in 2.881 HRD-in -72.77, -40.89 66.37, -21.2 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.51, 136.89 APE9-dihe-in -128.62, 136.22 APE8-dihe-in -78.96, 62.95 APE8-rot-na 34.87 APE67-dihe-in -73.77, -14.24 -40.1, -43.39 APE12-dist-na 14.711 APE11-dist-na 8.671 APE10-dist-na 10.011 APE9-dist-in 6.907 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[510, 783]] 1.0 AF-P04629-K1 TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
AF-P04629-K3A 502 791 796.0 No_ligand No_ligand Active DFGin 7.323 14.152 BLAminus -129.69, -166.67 52.24, 63.22 -79.66, 9.74 296.19, 93.99 -60.65, -28.88 in-in in 9.223 Saltbr-in 2.751 HRD-in -73.08, -44.78 68.09, -10.06 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.13, 137.21 APE9-dihe-in -116.97, 144.96 APE8-dihe-in -76.62, 65.71 APE8-rot-na 37.35 APE67-dihe-in -74.52, -3.17 -47.64, -33.3 APE12-dist-na 14.48 APE11-dist-na 9.213 APE10-dist-na 11.217 APE9-dist-in 6.744 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[510, 783]] 1.0 AF-P04629-K3 TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KVTA 501 787 796.0 YMX:60801 Type1 Inactive DFGin 6.09 14.64 ABAminus -123.93, -0.04 -156.57, 153.18 -119.59, 34.13 294.14, 82.51 42.35, 42.02 in-in in 9.206 Saltbr-in 3.066 HRD-in -72.66, -50.09 79.9, -10.34 in-out-in SNCioi out-in ActLoopNT-out 14.246 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.61, 123.93 APE9-dihe-in -109.81, 133.19 APE8-dihe-in -81.57, 68.18 APE8-rot-na 37.74 APE67-dihe-in -59.58, -23.04 -58.72, -36.84 APE12-dist-na 12.336 APE11-dist-na 12.164 APE10-dist-na 10.118 APE9-dist-in 7.101 None None None XRAY 2.45 0.195 0.239 A 293 283 4 0 0 0 [[510, 783]] 1.0 5kvt TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6IQNB 502 788 796.0 AQ6:60801 Type1 Inactive DFGin 6.802 15.004 ABAminus -105.93, -21.08 -155.49, 154.25 -121.75, -62.07 303.57, 79.9 179.93, 999.0 out-out out 10.242 Saltbr-out 7.062 HRD-in -80.44, -51.29 82.75, -12.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.38 APE8-dihe-in -85.76, 64.75 APE8-rot-na 31.54 APE67-dihe-in -69.39, -18.06 -57.29, -35.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.637 None None None XRAY 2.54 0.228 0.287 B 296 257 30 0 0 18 [[510, 783]] 1.0 6iqn TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4YNEA 502 793 796.0 4EK:60801 Type1 Inactive DFGin 6.462 14.412 ABAminus -116.57, -25.87 -138.59, 132.08 -91.61, -8.55 292.59, 93.64 65.27, 48.21 in-out in 9.954 Saltbr-out 4.23 HRD-out -88.11, 116.02 -91.0, 8.56 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.59, 116.87 APE9-dihe-in -104.89, 127.5 APE8-dihe-in -70.7, 65.57 APE8-rot-na 30.51 APE67-dihe-in -68.75, -18.3 -60.63, -34.72 APE12-dist-na 999.0 APE11-dist-na 12.241 APE10-dist-na 12.204 APE9-dist-in 6.75 None None None XRAY 2.023 0.185 0.216 A 303 276 16 0 0 9 [[510, 783]] 1.0 4yne TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4AOJA 500 789 796.0 V4Z:900 Type1 Inactive DFGin 7.022 14.275 ABAminus -110.98, -17.61 -143.63, 144.58 -112.81, -7.22 297.76, 85.92 -118.46, 999.0 in-in in 9.553 Saltbr-in 2.943 HRD-in -75.58, -50.98 84.9, -17.33 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.46, 125.37 APE9-dihe-in -125.37, 131.86 APE8-dihe-in -79.47, 66.97 APE8-rot-na 31.18 APE67-dihe-in -64.32, -24.98 -57.7, -37.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.148 None None None XRAY 2.75 0.221 0.242 A 329 260 30 0 0 16 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4AOJC 500 789 796.0 V4Z:900 Type1 Inactive DFGin 6.925 14.318 ABAminus -113.25, -25.61 -134.45, 155.26 -115.79, 26.54 295.12, 82.68 85.56, -93.23 in-out in 9.558 Saltbr-out 4.025 HRD-in -72.16, -45.71 73.74, -15.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.55 APE9-dihe-in -124.46, 135.84 APE8-dihe-in -82.75, 63.3 APE8-rot-na 24.35 APE67-dihe-in -63.5, -31.49 -48.92, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.541 APE9-dist-in 7.01 None None None XRAY 2.75 0.221 0.242 C 329 261 29 0 0 16 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
7VKNA 502 794 796.0 7GI:60801 Type1 Inactive DFGin 5.984 13.017 ABAminus -115.39, -41.87 -131.41, 143.63 -111.24, 20.98 314.85, 71.2 75.66, -101.93 in-out in 9.383 Saltbr-out 4.916 HRD-out -83.04, 118.83 -102.62, 15.46 out-out-in SNCooi out-in ActLoopNT-out 12.754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.12, 137.74 APE9-dihe-in -119.62, 140.33 APE8-dihe-in -80.18, 72.83 APE8-rot-na 34.86 APE67-dihe-in -69.38, -23.62 -70.62, -21.09 APE12-dist-na 11.42 APE11-dist-na 12.792 APE10-dist-na 11.858 APE9-dist-in 6.585 G595R None None XRAY 2.7 0.186 0.256 A 326 292 1 0 0 1 [[510, 783]] 1.0 7vkn TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4PMTA 501 787 796.0 31Y:60801 Type1 Inactive DFGin 6.131 14.794 None -112.67, -17.01 -137.68, 145.04 -146.35, 999.0 322.04, 80.71 999.0, 999.0 in-out in 9.806 Saltbr-out 3.633 HRD-in -75.33, -51.24 80.98, -15.04 out-out-in SNCooi out-in ActLoopNT-out 15.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.06, 128.33 APE9-dihe-in -117.66, 131.56 APE8-dihe-in -80.54, 63.91 APE8-rot-na 31.59 APE67-dihe-in -62.62, -22.15 -50.58, -36.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.218 None None None XRAY 2.1 0.186 0.209 A 291 269 18 0 0 5 [[510, 783]] 1.0 4pmt TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5I8AA 501 787 796.0 69C:60801 Type1 Inactive DFGin 6.738 14.39 None -97.16, -113.31 -48.28, 144.89 -102.36, 10.49 289.66, 94.22 178.06, 999.0 in-in in 9.629 Saltbr-in 3.266 HRD-in -70.07, -53.33 85.54, -20.79 in-out-in SNCioi out-in ActLoopNT-out 17.127 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.82, 123.59 APE9-dihe-in -112.87, 128.48 APE8-dihe-in -77.41, 62.86 APE8-rot-na 29.5 APE67-dihe-in -66.17, -22.6 -48.87, -35.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.245 None None None XRAY 2.33 0.18 0.209 A 296 266 21 0 0 4 [[510, 783]] 1.0 5i8a TYR_NTRK1_HUMAN TYR 1.7e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6IQNA 502 790 796.0 AQ6:60801 Type1 Inactive DFGin 7.14 15.11 None -103.61, -29.7 -117.2, -70.49 62.55, 999.0 316.84, 95.5 999.0, 999.0 in-out in 9.792 Saltbr-out 4.81 HRD-in -72.08, -53.46 85.54, -25.89 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.52, 109.29 APE9-dihe-in -102.41, 128.27 APE8-dihe-in -77.64, 69.03 APE8-rot-na 26.82 APE67-dihe-in -69.77, -22.47 -58.81, -29.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.33 None None None XRAY 2.54 0.228 0.287 A 296 271 18 0 0 12 [[510, 783]] 1.0 6iqn TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
7XAFA 498 796 796.0 FKT:801 Type1 Inactive DFGin 10.973 15.53 None -141.15, 137.13 74.8, 177.08 49.53, -82.17 307.2, 139.07 -1.5, 80.75 in-out in 9.481 Saltbr-out 3.701 HRD-out -81.39, 105.98 -86.3, -0.43 out-out-in SNCooi out-in ActLoopNT-out 15.438 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.83, 144.52 APE9-dihe-in -128.89, 123.51 APE8-dihe-in -76.16, 66.1 APE8-rot-na 29.0 APE67-dihe-in -71.14, -21.57 -60.15, -25.01 APE12-dist-na 15.023 APE11-dist-na 14.335 APE10-dist-na 10.417 APE9-dist-in 7.363 None None None XRAY 3.001 0.25 0.299 A 299 287 12 0 0 0 [[510, 783]] 1.0 7xaf TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6J5LA 502 790 796.0 B9C:60801 Type1 Inactive DFGin 6.127 13.793 None -112.0, -17.65 -146.4, 142.64 -117.9, -119.21 307.69, 78.13 -102.52, 999.0 in-in in 9.345 Saltbr-in 3.422 HRD-out -88.88, 113.33 -93.5, 4.21 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.51, 126.2 APE9-dihe-in -111.04, 133.44 APE8-dihe-in -88.74, 66.42 APE8-rot-na 38.43 APE67-dihe-in -63.3, -23.33 -52.55, -36.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.933 None None None XRAY 2.3 0.224 0.251 A 303 278 11 0 0 7 [[510, 783]] 1.0 6j5l TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PMEB 499 791 796.0 OOY:802 Type1 Inactive DFGin 8.041 12.775 None -108.23, 50.17 -34.62, -93.7 -97.7, 157.35 268.23, 140.64 158.45, -156.12 in-out in 9.687 Saltbr-out 4.362 HRD-in -75.61, -49.56 82.71, -16.4 out-out-none SNCoon out-none ActLoopNT-out 15.678 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.79 APE9-dihe-in -136.64, 129.71 APE8-dihe-in -72.47, 62.28 APE8-rot-na 30.59 APE67-dihe-in -74.1, -16.42 -50.47, -31.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.757 APE9-dist-in 7.019 None SEP677 SEP677 XRAY 3.0 0.259 0.315 B 311 271 22 0 0 5 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
9DAIA 501 796 796.0 STU:801 Type1 Inactive DFGin 7.329 15.102 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.698 Saltbr-in 3.253 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.495 None None None XRAY 2.864 0.22 0.277 A 320 264 32 0 0 19 [[510, 783]] 1.0 9dai TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
7VKOA 502 793 796.0 7GI:60801 Type1 Inactive DFGin 6.331 13.793 None -121.29, -23.19 -130.55, 158.61 -131.43, -91.62 300.81, 84.28 -89.58, -178.74 in-out in 9.271 Saltbr-out 4.844 HRD-out -83.55, 115.94 -93.33, 10.49 out-out-in SNCooi out-in ActLoopNT-out 15.213 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.01, 135.08 APE9-dihe-in -120.4, 150.84 APE8-dihe-in -84.95, 78.96 APE8-rot-na 37.61 APE67-dihe-in -53.21, -25.59 -47.58, -54.99 APE12-dist-na 10.738 APE11-dist-na 11.773 APE10-dist-na 9.731 APE9-dist-in 6.348 None None None XRAY 2.9 0.188 0.267 A 326 292 0 0 0 0 [[510, 783]] 1.0 7vko TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4AOJB 500 791 796.0 V4Z:900 Type1 Inactive DFGin 7.101 14.487 None -112.8, -14.1 -146.85, 148.75 -118.66, 999.0 304.25, 74.79 999.0, 999.0 in-out in 9.774 Saltbr-out 3.783 HRD-in -81.07, -46.03 78.05, -27.65 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.18 APE8-dihe-in -83.87, 63.88 APE8-rot-na 24.55 APE67-dihe-in -64.26, -27.58 -47.61, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.237 None None None XRAY 2.75 0.221 0.242 B 329 258 34 0 0 19 [[510, 783]] 1.0 4aoj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6DKGA 500 796 796.0 22L:801,GO7:802 Allosteric,Type2 Inactive DFGout 15.455 10.885 BBAminus -129.84, -153.68 -169.97, 108.79 -76.62, -30.73 288.52, 72.75 116.03, 999.0 in-out in 9.851 Saltbr-out 5.109 HRD-in -69.9, -49.64 79.4, -12.32 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.62, 109.43 APE9-dihe-in -100.38, 134.76 APE8-dihe-in -83.29, 59.25 APE8-rot-na 32.8 APE67-dihe-in -64.09, -21.64 -42.0, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.357 None None None XRAY 2.53 0.189 0.225 A 320 276 21 0 0 9 [[510, 783]] 1.0 6dkg TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6DKIA 500 796 796.0 22L:801,GOD:802 Allosteric,Type2 Inactive DFGout 15.657 10.339 BBAminus -138.27, -151.87 -172.63, 116.91 -81.37, -9.66 281.96, 77.97 75.28, 999.0 in-out in 9.895 Saltbr-out 4.913 HRD-in -65.87, -50.46 77.43, -14.55 out-out-in SNCooi out-in ActLoopNT-out 16.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.45, 122.12 APE9-dihe-in -117.82, 128.28 APE8-dihe-in -76.01, 65.16 APE8-rot-na 30.62 APE67-dihe-in -68.36, -18.63 -49.98, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.307 None None None XRAY 2.11 0.186 0.227 A 320 279 18 0 0 6 [[510, 783]] 1.0 6dki TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6D1ZA 483 796 796.0 FQD:801,FQM:803 Allosteric,Type3 Inactive DFGout 12.567 7.366 BBAminus 167.82, 150.89 -150.57, 163.47 -100.59, 23.19 306.23, 116.03 65.85, 23.26 in-out in 9.854 Saltbr-out 6.197 HRD-in -66.06, -47.82 80.23, -21.06 out-out-in SNCooi out-in ActLoopNT-out 15.302 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.79, 107.46 APE9-dihe-in -108.68, 135.71 APE8-dihe-in -79.15, 66.52 APE8-rot-na 33.74 APE67-dihe-in -68.05, -19.94 -54.02, -36.77 APE12-dist-na 999.0 APE11-dist-na 14.491 APE10-dist-na 10.819 APE9-dist-in 7.253 None None None XRAY 1.87 0.18 0.21 A 320 290 16 0 0 4 [[510, 783]] 1.0 6d1z TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
7VKMA 502 795 796.0 No_ligand No_ligand Inactive DFGout 12.323 7.432 BBAminus 176.27, 165.41 -156.55, 175.73 -110.4, 8.5 305.75, 118.24 88.56, 16.82 in-out in 9.568 Saltbr-out 4.915 HRD-in -72.61, -55.29 84.51, -23.12 out-out-in SNCooi out-in ActLoopNT-out 15.661 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.68, 125.36 APE9-dihe-in -117.44, 136.53 APE8-dihe-in -89.28, 75.32 APE8-rot-na 30.03 APE67-dihe-in -68.93, -24.54 -65.78, -30.21 APE12-dist-na 14.249 APE11-dist-na 15.511 APE10-dist-na 10.87 APE9-dist-in 7.207 G595R None None XRAY 2.55 0.202 0.257 A 326 294 0 0 0 0 [[510, 783]] 1.0 7vkm TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4PMPA 501 787 796.0 31W:60801 Type1 Inactive DFGout 15.486 10.55 BBAminus -133.03, -157.37 -173.03, 103.22 -69.9, -32.34 288.02, 70.73 77.22, -47.74 in-out in 9.568 Saltbr-out 4.647 HRD-in -67.48, -51.34 82.08, -14.32 out-out-in SNCooi out-in ActLoopNT-out 15.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.87, 121.14 APE9-dihe-in -118.75, 136.28 APE8-dihe-in -80.92, 64.59 APE8-rot-na 34.05 APE67-dihe-in -64.12, -19.76 -49.55, -38.41 APE12-dist-na 999.0 APE11-dist-na 13.915 APE10-dist-na 9.735 APE9-dist-in 7.19 None None None XRAY 1.8 0.166 0.185 A 291 276 11 0 0 3 [[510, 783]] 1.0 4pmp TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5H3QA 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.708 6.583 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.447 Saltbr-out 5.851 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.748 APE11-dist-na 15.2 APE10-dist-na 10.681 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324 303 10 0 0 0 [[510, 783]] 1.0 5h3q TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4PMMA 501 787 796.0 31V:60801 Type2 Inactive DFGout 12.146 10.95 BBAminus -133.43, -162.51 -156.69, 94.05 -92.35, -31.82 309.48, 143.39 59.02, -8.13 in-out in 9.286 Saltbr-out 4.76 HRD-in -72.63, -53.5 82.36, -15.27 out-out-in SNCooi out-in ActLoopNT-out 16.095 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.51, 115.08 APE9-dihe-in -105.75, 129.0 APE8-dihe-in -80.23, 63.87 APE8-rot-na 30.48 APE67-dihe-in -66.31, -17.94 -46.68, -40.06 APE12-dist-na 13.786 APE11-dist-na 15.797 APE10-dist-na 10.76 APE9-dist-in 7.145 None None None XRAY 2.0 0.166 0.199 A 291 281 6 0 0 0 [[510, 783]] 1.0 4pmm TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5JFSA 502 793 796.0 6K0:64000 Type2 Inactive DFGout 12.527 10.983 BBAminus -135.78, -160.84 -157.76, 107.91 -107.26, 3.47 322.34, 129.58 106.13, 999.0 in-in in 9.81 Saltbr-in 2.888 HRD-in -71.87, -49.52 79.25, -12.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.58 APE8-dihe-in -83.43, 60.43 APE8-rot-na 33.02 APE67-dihe-in -63.9, -20.6 -49.99, -40.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.565 None None None XRAY 2.07 0.171 0.191 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfs TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5JFVA 502 793 796.0 6K1:64000 Type2 Inactive DFGout 12.638 11.028 BBAminus -141.43, -159.86 -155.63, 106.71 -102.51, 5.29 321.04, 131.31 88.83, 999.0 out-out out 10.053 Saltbr-out 3.842 HRD-in -71.26, -49.89 78.63, -12.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.24 APE8-dihe-in -81.16, 59.69 APE8-rot-na 33.1 APE67-dihe-in -63.0, -20.76 -49.39, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.533 None None None XRAY 1.59 0.173 0.192 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfv TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5JFWA 502 793 796.0 6K2:64000 Type2 Inactive DFGout 12.659 11.195 BBAminus -133.87, -158.13 -156.47, 107.62 -101.73, 2.97 321.78, 129.01 71.48, 999.0 out-out out 10.196 Saltbr-out 8.11 HRD-in -70.93, -50.56 80.08, -11.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.64 APE8-dihe-in -79.87, 59.55 APE8-rot-na 31.09 APE67-dihe-in -62.34, -22.4 -47.37, -43.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 None None None XRAY 1.52 0.18 0.209 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfw TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5JFXA 502 793 796.0 6K4:64000 Type2 Inactive DFGout 12.748 11.04 BBAminus -133.96, -162.47 -154.94, 107.94 -100.19, 17.72 319.82, 130.69 65.97, 999.0 out-in out 10.117 Saltbr-in 3.479 HRD-in -70.26, -49.25 76.75, -14.14 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.45 APE8-dihe-in -81.06, 57.38 APE8-rot-na 33.47 APE67-dihe-in -62.32, -20.75 -46.26, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.65 None None None XRAY 1.63 0.203 0.232 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfx TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6DKWA 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.797 11.147 BBAminus -132.36, -152.04 -163.87, 118.82 -86.57, 0.12 282.19, 82.2 87.26, 999.0 out-out out 10.036 Saltbr-out 7.707 HRD-in -70.19, -47.29 72.43, -13.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.7 APE8-dihe-in -77.96, 56.47 APE8-rot-na 32.78 APE67-dihe-in -69.34, -24.62 -48.56, -36.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.457 None None None XRAY 2.91 0.233 0.262 A 308 271 21 0 0 18 [[510, 783]] 1.0 6dkw TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6DKWB 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.312 11.664 BBAminus -137.72, -157.97 -167.56, 133.61 -110.92, -23.72 305.39, 77.76 119.48, 999.0 in-out in 9.806 Saltbr-out 7.952 HRD-in -71.64, -50.67 77.06, -19.15 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.56, 120.27 APE9-dihe-in -83.42, 115.11 APE8-dihe-in -79.02, 56.72 APE8-rot-na 32.67 APE67-dihe-in -66.06, -29.18 -49.12, -39.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.891 None None None XRAY 2.91 0.233 0.262 B 308 263 29 0 0 16 [[510, 783]] 1.0 6dkw TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PL2A 499 795 796.0 OOM:801 Type2 Inactive DFGout 12.612 11.733 BBAminus -133.35, -162.35 -156.24, 113.82 -105.83, 45.09 316.55, 125.06 63.21, -157.53 in-out in 8.738 Saltbr-out 4.349 HRD-in -67.21, -55.46 83.15, -23.62 out-out-in SNCooi out-in ActLoopNT-out 18.179 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.48, 132.06 APE9-dihe-in -120.18, 125.99 APE8-dihe-in -79.18, 69.41 APE8-rot-na 32.0 APE67-dihe-in -66.97, -17.29 -57.88, -39.56 APE12-dist-na 10.501 APE11-dist-na 10.402 APE10-dist-na 5.73 APE9-dist-in 7.3 None SEP677 SEP677 XRAY 2.59 0.202 0.274 A 311 297 0 0 0 0 [[510, 783]] 1.0 6pl2 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
7XBIA 497 795 796.0 CVY:801 Type2 Inactive DFGout 14.107 10.796 BBAminus -137.82, -164.37 -150.04, 97.3 -71.59, -9.66 278.32, 66.5 74.67, 31.7 in-out in 9.747 Saltbr-out 4.318 HRD-in -82.22, -63.27 93.82, -12.28 out-out-in SNCooi out-in ActLoopNT-out 18.423 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.41, 123.03 APE9-dihe-in -113.59, 129.96 APE8-dihe-in -80.4, 65.23 APE8-rot-na 30.24 APE67-dihe-in -62.07, -20.59 -54.97, -38.49 APE12-dist-na 10.546 APE11-dist-na 11.082 APE10-dist-na 6.243 APE9-dist-in 7.206 None None None XRAY 2.16 0.194 0.246 A 311 299 0 0 0 0 [[510, 783]] 1.0 7xbi TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
8J5XA 500 795 796.0 A4U:801 Type2 Inactive DFGout 13.036 10.369 BBAminus -130.91, -158.27 -162.66, 108.46 -93.68, 5.06 291.9, 93.65 78.16, -167.64 in-in in 8.889 Saltbr-in 2.61 HRD-in -70.53, -55.33 83.0, -11.79 in-out-in SNCioi out-in ActLoopNT-out 18.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.89, 140.84 APE9-dihe-in -129.21, 130.11 APE8-dihe-in -79.69, 64.42 APE8-rot-na 33.0 APE67-dihe-in -65.79, -20.2 -56.52, -34.65 APE12-dist-na 13.297 APE11-dist-na 8.895 APE10-dist-na 6.03 APE9-dist-in 7.218 G595R None None XRAY 2.092 0.184 0.22 A 299 296 0 0 0 0 [[510, 783]] 1.0 8j5x TYR_NTRK1_HUMAN TYR 9.7e-99 335.8 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PL4A 485 795 796.0 OO7:801 Type3 Inactive DFGout 12.331 6.751 BBAminus 163.32, 156.14 -161.4, 166.2 -103.41, 14.03 294.82, 105.0 75.38, 27.87 in-out in 9.548 Saltbr-out 6.947 HRD-in -67.83, -53.77 81.67, -11.19 out-out-in SNCooi out-in ActLoopNT-out 15.677 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.06, 119.89 APE9-dihe-in -108.16, 133.15 APE8-dihe-in -81.07, 64.06 APE8-rot-na 35.11 APE67-dihe-in -63.69, -22.36 -54.01, -37.98 APE12-dist-na 13.774 APE11-dist-na 15.065 APE10-dist-na 10.803 APE9-dist-in 7.259 None SEP677 SEP677 XRAY 2.06 0.202 0.239 A 311 299 3 0 0 0 [[510, 783]] 1.0 6pl4 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6D20A 482 796 796.0 FQD:801,FQG:802 Allosteric,Type3 Inactive DFGout 12.121 7.682 None 160.41, 153.19 -151.74, 163.05 -104.33, 22.77 307.7, 135.7 70.27, 21.28 out-out out 10.011 Saltbr-out 4.832 HRD-in -65.64, -51.3 81.74, -20.54 out-out-in SNCooi out-in ActLoopNT-out 15.27 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.06, 110.16 APE9-dihe-in -105.1, 135.52 APE8-dihe-in -82.75, 65.28 APE8-rot-na 34.64 APE67-dihe-in -60.75, -21.14 -48.61, -41.93 APE12-dist-na 999.0 APE11-dist-na 15.38 APE10-dist-na 10.975 APE9-dist-in 7.221 None None None XRAY 1.94 0.172 0.207 A 320 296 13 0 0 2 [[510, 783]] 1.0 6d20 TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4F0IA 501 790 796.0 No_ligand No_ligand Inactive DFGout 12.724 6.541 None 168.4, 147.46 -150.91, -178.97 -114.84, 17.84 296.33, 102.98 77.14, 17.47 out-out out 10.072 Saltbr-out 3.783 HRD-in -70.62, -54.37 86.42, -21.28 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.87, 117.07 APE9-dihe-in -123.33, 147.3 APE8-dihe-in -80.93, 68.13 APE8-rot-na 33.21 APE67-dihe-in -63.68, -22.55 -54.54, -38.97 APE12-dist-na 18.887 APE11-dist-na 14.675 APE10-dist-na 10.919 APE9-dist-in 7.231 None None None XRAY 2.302 0.185 0.241 A 300 284 6 0 0 0 [[510, 783]] 1.0 4f0i TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4F0IB 501 794 796.0 No_ligand No_ligand Inactive DFGout 12.543 7.011 None 166.76, 148.15 -155.18, 178.64 -114.64, 15.88 300.05, 104.73 73.51, 23.99 in-out in 9.546 Saltbr-out 3.613 HRD-in -74.85, -50.62 80.22, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.499 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.15, 119.22 APE9-dihe-in -115.7, 131.68 APE8-dihe-in -79.13, 66.63 APE8-rot-na 32.83 APE67-dihe-in -65.29, -20.15 -62.09, -33.78 APE12-dist-na 15.648 APE11-dist-na 15.205 APE10-dist-na 10.671 APE9-dist-in 7.475 None None None XRAY 2.302 0.185 0.241 B 300 294 0 0 0 0 [[510, 783]] 1.0 4f0i TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4GT5A 498 793 796.0 No_ligand No_ligand Inactive DFGout 12.604 7.347 None 159.19, 156.78 -162.75, 171.4 -109.98, 15.11 307.11, 107.92 73.58, 34.63 in-none in 9.757 Saltbr-none 999.0 HRD-in -59.3, -59.24 86.11, -5.83 none-out-in SNCnoi out-in ActLoopNT-out 15.797 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.6, 126.13 APE9-dihe-in -108.71, 129.99 APE8-dihe-in -77.33, 65.58 APE8-rot-na 28.73 APE67-dihe-in -65.65, -17.34 -57.96, -37.68 APE12-dist-na 15.147 APE11-dist-na 15.37 APE10-dist-na 11.229 APE9-dist-in 7.444 None None None XRAY 2.398 0.204 0.248 A 306 290 6 0 0 0 [[510, 783]] 1.0 4gt5 TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6D22A 502 794 796.0 No_ligand No_ligand Inactive DFGout 12.606 7.143 None 175.88, 158.7 -166.39, 174.44 -112.95, 15.95 304.35, 111.16 86.04, 4.07 in-out in 9.613 Saltbr-out 3.848 HRD-in -74.57, -54.54 85.84, -16.79 out-out-in SNCooi out-in ActLoopNT-out 15.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.68, 117.35 APE9-dihe-in -107.64, 132.88 APE8-dihe-in -74.3, 62.56 APE8-rot-na 38.38 APE67-dihe-in -63.87, -17.11 -48.79, -48.38 APE12-dist-na 13.895 APE11-dist-na 15.264 APE10-dist-na 10.95 APE9-dist-in 7.577 None None None XRAY 2.46 0.178 0.236 A 307 293 0 0 0 0 [[510, 783]] 1.0 6d22 TYR_NTRK1_HUMAN TYR 2e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6DKBA 501 796 796.0 FKY:4000 Type1 Inactive DFGout 15.332 10.748 None -132.31, -154.04 -173.63, 117.2 -89.02, -138.07 293.55, 87.71 -145.33, 999.0 out-in out 10.015 Saltbr-in 3.343 HRD-in -63.64, -46.04 75.89, -18.83 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 136.46 APE9-dihe-in -131.13, 141.89 APE8-dihe-in -81.0, 68.63 APE8-rot-na 33.49 APE67-dihe-in -61.76, -21.1 -51.01, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.273 None None None XRAY 2.68 0.217 0.245 A 320 272 24 0 0 11 [[510, 783]] 1.0 6dkb TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMOA 500 796 796.0 6UM:60901 Type1 Inactive DFGout 12.319 11.374 None -138.6, -165.07 -158.74, 98.32 -111.51, -171.02 340.4, 114.97 156.89, 999.0 out-out out 10.631 Saltbr-out 6.316 HRD-in -66.47, -58.38 85.91, -20.7 out-out-in SNCooi out-in ActLoopNT-out 17.221 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.17, 145.62 APE9-dihe-in -124.84, 130.96 APE8-dihe-in -87.13, 68.95 APE8-rot-na 25.74 APE67-dihe-in -56.92, -24.53 -50.66, -48.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.161 None None None XRAY 2.67 0.196 0.243 A 329 290 7 0 0 2 [[510, 783]] 1.0 5kmo TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4PMSA 501 787 796.0 31X:60801 Type1.5_Back Inactive DFGout 12.026 11.607 None -132.53, -155.25 -159.75, 97.5 -105.99, 141.7 318.1, 112.95 -75.26, -27.15 in-out in 9.471 Saltbr-out 6.462 HRD-in -62.95, -59.22 88.04, -25.42 out-out-in SNCooi out-in ActLoopNT-out 15.92 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 110.83 APE9-dihe-in -104.11, 139.32 APE8-dihe-in -84.02, 66.3 APE8-rot-na 28.87 APE67-dihe-in -67.29, -19.63 -45.69, -39.43 APE12-dist-na 17.385 APE11-dist-na 17.142 APE10-dist-na 12.483 APE9-dist-in 7.233 None None None XRAY 2.8 0.168 0.24 A 291 279 8 0 0 2 [[510, 783]] 1.0 4pms TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
8J5WA 485 795 796.0 A4U:801 Type2 Inactive DFGout 14.106 9.904 None -124.93, -156.11 -165.36, 86.03 -59.52, 147.81 290.47, 86.44 107.07, -85.27 in-out in 9.572 Saltbr-out 6.072 HRD-out -97.68, 106.96 -81.54, 7.53 out-out-in SNCooi out-in ActLoopNT-out 16.096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.59, 129.11 APE9-dihe-in -117.85, 126.3 APE8-dihe-in -74.82, 63.31 APE8-rot-na 31.0 APE67-dihe-in -67.5, -17.44 -56.64, -33.03 APE12-dist-na 15.441 APE11-dist-na 16.069 APE10-dist-na 11.4 APE9-dist-in 7.04 F589L None None XRAY 2.28 0.222 0.266 A 313 298 4 0 0 0 [[510, 783]] 1.0 8j5w TYR_NTRK1_HUMAN TYR 2.6e-100 340.9 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
8J61A 499 795 796.0 A0X:801 Type2 Inactive DFGout 13.23 11.155 None -134.57, -179.08 -139.19, 96.75 -83.33, 178.03 307.14, 171.93 171.37, -120.57 out-out out 10.109 Saltbr-out 6.455 HRD-in -80.6, -37.38 66.53, -21.87 out-out-in SNCooi out-in ActLoopNT-out 15.574 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -141.71, 130.82 APE9-dihe-in -115.65, 127.68 APE8-dihe-in -74.28, 70.21 APE8-rot-na 29.28 APE67-dihe-in -73.67, -7.76 -58.39, -28.44 APE12-dist-na 16.775 APE11-dist-na 15.162 APE10-dist-na 11.578 APE9-dist-in 6.997 None None None XRAY 3.051 0.209 0.255 A 299 291 6 0 0 0 [[510, 783]] 1.0 8j61 TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
8J63A 500 796 796.0 A6X:801 Type2 Inactive DFGout 13.758 10.314 None -148.15, -172.21 -147.6, 96.08 -75.43, 162.83 293.22, 106.5 105.33, -112.14 in-out in 9.819 Saltbr-out 4.245 HRD-in -78.37, -44.48 66.44, -4.46 out-out-in SNCooi out-in ActLoopNT-out 15.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.3, 149.87 APE9-dihe-in -128.22, 125.62 APE8-dihe-in -76.56, 58.46 APE8-rot-na 30.42 APE67-dihe-in -72.95, -14.47 -58.85, -23.58 APE12-dist-na 17.283 APE11-dist-na 16.106 APE10-dist-na 11.849 APE9-dist-in 7.257 None None None XRAY 3.001 0.233 0.289 A 299 291 6 0 0 0 [[510, 783]] 1.0 8j63 TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5WR7A 489 792 796.0 RCH:801 Type2 Inactive DFGout 14.663 8.431 None -131.73, -148.47 -166.21, 161.63 -141.28, 117.22 276.93, 88.17 -99.45, -3.58 out-out out 10.191 Saltbr-out 7.425 HRD-in -69.6, -49.89 70.97, 2.48 out-out-in SNCooi out-in ActLoopNT-out 18.125 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.65, 116.34 APE9-dihe-in -122.66, 128.76 APE8-dihe-in -78.54, 68.52 APE8-rot-na 32.36 APE67-dihe-in -68.82, -19.66 -50.73, -45.45 APE12-dist-na 999.0 APE11-dist-na 14.927 APE10-dist-na 10.089 APE9-dist-in 7.042 None SEP677 SEP677 XRAY 2.76 0.208 0.234 A 304 302 2 0 0 2 [[510, 783]] 1.0 5wr7 TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PL1A 500 795 796.0 OOJ:801 Type2 Inactive DFGout 12.202 11.545 None -140.12, -163.59 -151.72, 95.42 -94.74, 114.97 323.02, 137.75 -51.78, -31.38 in-out in 9.537 Saltbr-out 4.254 HRD-in -65.5, -55.98 80.9, -7.13 out-out-in SNCooi out-in ActLoopNT-out 16.016 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.78, 119.43 APE9-dihe-in -106.09, 130.79 APE8-dihe-in -83.67, 66.03 APE8-rot-na 34.24 APE67-dihe-in -63.93, -22.81 -49.57, -43.95 APE12-dist-na 999.0 APE11-dist-na 15.228 APE10-dist-na 10.758 APE9-dist-in 7.134 None SEP677 SEP677 XRAY 2.03 0.22 0.26 A 311 290 6 0 0 3 [[510, 783]] 1.0 6pl1 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PL3A 500 795 796.0 OOD:801 Type2 Inactive DFGout 11.564 10.91 None -143.28, -158.28 -155.92, 104.62 -110.35, 130.24 309.4, 131.25 -70.56, -23.22 in-out in 9.269 Saltbr-out 3.683 HRD-in -79.21, -48.25 72.7, -2.08 out-out-in SNCooi out-in ActLoopNT-out 16.474 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.4, 114.8 APE9-dihe-in -102.82, 125.91 APE8-dihe-in -81.39, 70.95 APE8-rot-na 32.5 APE67-dihe-in -65.12, -18.02 -56.45, -36.14 APE12-dist-na 15.256 APE11-dist-na 16.285 APE10-dist-na 11.683 APE9-dist-in 7.215 None None None XRAY 3.0 0.211 0.272 A 311 291 5 0 0 0 [[510, 783]] 1.0 6pl3 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PMAA 500 795 796.0 OQS:801 Type2 Inactive DFGout 12.122 11.277 None -135.79, -172.95 -145.14, 102.3 -103.72, 124.51 321.1, 137.33 -54.09, -40.43 in-in in 9.047 Saltbr-in 2.591 HRD-in -75.81, -50.56 78.93, -17.98 in-out-in SNCioi out-in ActLoopNT-out 16.09 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -134.69, 117.23 APE9-dihe-in -107.06, 120.83 APE8-dihe-in -77.63, 65.04 APE8-rot-na 27.44 APE67-dihe-in -72.95, -15.51 -57.1, -33.54 APE12-dist-na 15.911 APE11-dist-na 15.668 APE10-dist-na 10.999 APE9-dist-in 7.264 None SEP677 SEP677 XRAY 2.53 0.209 0.266 A 311 290 6 0 0 0 [[510, 783]] 1.0 6pma TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PMBA 500 795 796.0 OQM:801 Type2 Inactive DFGout 11.66 11.672 None -132.37, -159.76 -148.31, 103.43 -105.33, 151.54 318.17, 135.0 -87.93, -24.35 in-in in 9.175 Saltbr-in 3.46 HRD-in -70.6, -56.1 77.89, -14.23 in-out-in SNCioi out-in ActLoopNT-out 16.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.62, 125.62 APE9-dihe-in -118.02, 123.95 APE8-dihe-in -78.96, 65.2 APE8-rot-na 32.2 APE67-dihe-in -67.87, -21.55 -67.55, -29.76 APE12-dist-na 15.649 APE11-dist-na 16.578 APE10-dist-na 11.695 APE9-dist-in 7.186 None None None XRAY 2.81 0.219 0.282 A 311 288 8 0 0 0 [[510, 783]] 1.0 6pmb TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PMCA 500 795 796.0 OQJ:801 Type2 Inactive DFGout 11.807 11.813 None -132.04, -168.64 -145.63, 90.01 -97.69, 142.15 324.37, 130.77 -66.35, -36.3 in-in in 9.651 Saltbr-in 3.527 HRD-in -82.16, -55.48 89.25, -24.57 in-out-in SNCioi out-in ActLoopNT-out 15.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.7, 118.63 APE9-dihe-in -108.33, 130.52 APE8-dihe-in -80.54, 62.41 APE8-rot-na 37.39 APE67-dihe-in -54.69, -23.0 -49.98, -41.68 APE12-dist-na 14.154 APE11-dist-na 15.681 APE10-dist-na 11.236 APE9-dist-in 7.226 None SEP677 SEP677 XRAY 2.19 0.25 0.298 A 311 289 7 0 0 0 [[510, 783]] 1.0 6pmc TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6NSPA 500 795 796.0 L0P:801 Type3 Inactive DFGout 12.341 6.918 None 147.69, 153.73 -147.15, -178.06 -113.86, 11.77 292.26, 110.9 67.54, 37.24 in-out in 9.506 Saltbr-out 9.102 HRD-in -80.74, -60.67 84.66, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.69 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -135.01, 112.02 APE9-dihe-in -104.87, 129.45 APE8-dihe-in -77.35, 65.98 APE8-rot-na 35.66 APE67-dihe-in -61.95, -17.33 -58.27, -39.42 APE12-dist-na 13.388 APE11-dist-na 15.055 APE10-dist-na 10.661 APE9-dist-in 7.371 None None None XRAY 2.31 0.192 0.255 A 297 293 3 0 0 0 [[510, 783]] 1.0 6nsp TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6NPTA 491 795 796.0 KWY:801 Type3 Inactive DFGout 12.438 7.501 None 158.18, 155.8 -152.05, 169.87 -107.1, 19.78 311.07, 121.3 72.87, 27.1 out-out out 10.008 Saltbr-out 5.238 HRD-in -70.4, -52.75 80.08, -14.8 out-out-in SNCooi out-in ActLoopNT-out 15.592 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.83, 113.75 APE9-dihe-in -105.63, 131.16 APE8-dihe-in -80.28, 65.31 APE8-rot-na 34.86 APE67-dihe-in -61.58, -17.65 -56.43, -41.31 APE12-dist-na 14.426 APE11-dist-na 15.187 APE10-dist-na 10.648 APE9-dist-in 7.262 None SEP677 SEP677 XRAY 2.19 0.227 0.276 A 305 288 10 0 0 0 [[510, 783]] 1.0 6npt TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6NSSA 485 795 796.0 L0M:801 Type3 Inactive DFGout 11.815 7.025 None 168.65, 153.78 -158.36, 171.84 -109.19, 24.3 297.57, 118.56 67.82, 28.96 in-out in 9.528 Saltbr-out 5.666 HRD-in -90.15, -59.03 81.79, -5.07 out-out-in SNCooi out-in ActLoopNT-out 16.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.54, 111.04 APE9-dihe-in -105.46, 130.52 APE8-dihe-in -80.81, 65.09 APE8-rot-na 33.3 APE67-dihe-in -66.94, -20.44 -58.3, -34.71 APE12-dist-na 13.068 APE11-dist-na 15.018 APE10-dist-na 10.687 APE9-dist-in 7.449 None None None XRAY 1.97 0.184 0.218 A 311 303 3 0 0 0 [[510, 783]] 1.0 6nss TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6D1YA 481 796 796.0 FQJ:801 Type3 Inactive DFGout 12.673 6.856 None 169.8, 145.64 -149.42, -179.74 -114.54, 6.91 301.35, 101.16 76.21, 25.01 out-out out 10.052 Saltbr-out 5.442 HRD-in -65.07, -51.13 81.32, -20.97 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.27, 120.93 APE9-dihe-in -115.22, 138.24 APE8-dihe-in -78.51, 63.15 APE8-rot-na 29.74 APE67-dihe-in -66.08, -21.72 -48.21, -36.42 APE12-dist-na 999.0 APE11-dist-na 14.923 APE10-dist-na 10.709 APE9-dist-in 7.254 None None None XRAY 1.93 0.179 0.224 A 320 300 16 0 0 4 [[510, 783]] 1.0 6d1y TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMIA 486 796 796.0 6UE:901 Type3 Inactive DFGout 12.102 7.293 None 161.69, 152.83 -154.44, 168.25 -105.96, 25.99 305.3, 125.58 65.11, 30.06 in-out in 9.486 Saltbr-out 6.201 HRD-in -70.33, -55.53 75.77, -9.09 out-out-in SNCooi out-in ActLoopNT-out 15.758 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.77, 111.89 APE9-dihe-in -104.52, 130.31 APE8-dihe-in -84.87, 65.08 APE8-rot-na 32.16 APE67-dihe-in -62.84, -22.31 -53.23, -38.24 APE12-dist-na 14.003 APE11-dist-na 15.654 APE10-dist-na 10.916 APE9-dist-in 7.529 None None None XRAY 1.87 0.21 0.247 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmi TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMJA 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.602 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.714 Saltbr-in 2.772 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.107 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.016 APE11-dist-na 15.494 APE10-dist-na 11.096 APE9-dist-in 7.6 None None None XRAY 2.04 0.196 0.226 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMKA 484 796 796.0 6UG:60901 Type3 Inactive DFGout 12.367 7.444 None 155.23, 152.12 -152.95, 175.79 -116.52, 20.57 308.16, 114.44 75.73, 21.77 in-out in 9.763 Saltbr-out 6.397 HRD-in -59.42, -51.85 75.91, -16.02 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.53, 119.76 APE9-dihe-in -107.42, 137.31 APE8-dihe-in -83.03, 63.78 APE8-rot-na 29.2 APE67-dihe-in -62.44, -17.14 -49.56, -42.83 APE12-dist-na 14.029 APE11-dist-na 15.416 APE10-dist-na 11.102 APE9-dist-in 7.25 None None None XRAY 2.24 0.227 0.281 A 329 302 5 0 0 0 [[510, 783]] 1.0 5kmk TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMMA 484 796 796.0 6UJ:60901 Type3 Inactive DFGout 12.368 7.184 None 157.73, 155.5 -160.68, 165.48 -107.15, 26.91 307.0, 120.61 71.24, 15.54 in-out in 9.463 Saltbr-out 5.114 HRD-in -61.78, -57.27 78.61, -13.21 out-out-in SNCooi out-in ActLoopNT-out 15.663 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.76, 118.16 APE9-dihe-in -103.64, 132.25 APE8-dihe-in -82.99, 66.28 APE8-rot-na 32.09 APE67-dihe-in -66.37, -19.35 -53.37, -35.26 APE12-dist-na 13.548 APE11-dist-na 15.633 APE10-dist-na 11.207 APE9-dist-in 7.428 None None None XRAY 2.12 0.216 0.264 A 329 300 5 0 0 0 [[510, 783]] 1.0 5kmm TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMLA 474 796 796.0 6UH:60901 Type3 Inactive DFGout 12.398 7.282 None 158.81, 154.45 -158.96, 169.19 -111.19, 29.55 308.68, 112.5 65.84, 21.76 in-out in 9.957 Saltbr-out 5.226 HRD-out -95.27, 113.75 -82.3, 1.42 out-out-in SNCooi out-in ActLoopNT-out 16.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.36, 117.18 APE9-dihe-in -101.68, 134.53 APE8-dihe-in -83.65, 62.57 APE8-rot-na 32.66 APE67-dihe-in -60.72, -23.67 -48.68, -40.28 APE12-dist-na 14.512 APE11-dist-na 15.25 APE10-dist-na 11.024 APE9-dist-in 7.223 None None None XRAY 2.01 0.204 0.232 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kml TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
5KMNA 474 796 796.0 6UK:60901 Type3 Inactive DFGout 12.55 7.54 None 154.23, 154.5 -157.96, 168.93 -109.62, 31.32 313.55, 117.07 68.77, 19.82 in-out in 9.889 Saltbr-out 4.996 HRD-out -100.52, 112.12 -80.72, -0.22 out-out-in SNCooi out-in ActLoopNT-out 16.168 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.74, 114.86 APE9-dihe-in -100.75, 133.2 APE8-dihe-in -82.26, 61.08 APE8-rot-na 30.54 APE67-dihe-in -63.96, -19.55 -48.16, -39.69 APE12-dist-na 14.561 APE11-dist-na 15.367 APE10-dist-na 11.163 APE9-dist-in 7.323 None None None XRAY 2.14 0.195 0.222 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kmn TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
4YPSA 502 790 796.0 4F6:60801 Type1 Inactive None 999.0 999.0 None -112.08, -158.35 4.87, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.117 Saltbr-out 9.125 HRD-out -86.73, 118.76 -94.8, 9.98 out-out-in SNCooi out-in ActLoopNT-out 17.743 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.0, 118.89 APE9-dihe-in -107.28, 139.4 APE8-dihe-in -81.62, 61.84 APE8-rot-na 34.18 APE67-dihe-in -64.91, -18.75 -58.48, -35.44 APE12-dist-na 999.0 APE11-dist-na 14.606 APE10-dist-na 10.321 APE9-dist-in 7.226 None None None XRAY 2.101 0.203 0.257 A 303 275 14 0 0 5 [[510, 783]] 1.0 4yps TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PMEA 500 788 796.0 OOY:802 Type1 Inactive None 11.274 14.866 None -103.64, 63.03 -6.61, -101.22 -108.6, -79.47 316.94, 83.99 80.48, -131.89 in-out in 9.65 Saltbr-out 4.197 HRD-in -82.82, -49.18 87.37, -21.9 out-out-in SNCooi out-in ActLoopNT-out 15.626 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.61, 116.38 APE9-dihe-in -119.8, 127.41 APE8-dihe-in -74.42, 64.21 APE8-rot-na 33.13 APE67-dihe-in -65.79, -8.94 -53.59, -37.65 APE12-dist-na 999.0 APE11-dist-na 14.349 APE10-dist-na 10.401 APE9-dist-in 7.124 None SEP677 SEP677 XRAY 3.0 0.259 0.315 A 311 268 21 0 0 3 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
6PMEC 500 790 796.0 OOY:802 Type1 Inactive None 11.519 15.004 None -105.17, 39.93 27.01, -158.9 -47.91, -126.82 299.14, 109.98 111.56, -123.09 in-out in 9.672 Saltbr-out 4.961 HRD-in -71.5, -57.03 89.79, -15.29 out-out-in SNCooi out-in ActLoopNT-out 15.62 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.99, 111.57 APE9-dihe-in -114.5, 136.16 APE8-dihe-in -76.15, 63.17 APE8-rot-na 31.13 APE67-dihe-in -65.29, -26.47 -45.99, -41.18 APE12-dist-na 16.084 APE11-dist-na 14.681 APE10-dist-na 10.666 APE9-dist-in 6.964 None SEP677 SEP677 XRAY 3.0 0.259 0.315 C 311 274 17 0 0 2 [[510, 783]] 1.0 6pme TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor

TYR_NTRK1 (High affinity nerve growth factor receptor)

Total number of chains: 64
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 27 42.2% 4F0IB
DFGout BBAminus 17 26.6% 8J5XA
DFGin None 9 14.1% 7VKOA
DFGin ABAminus 6 9.4% 7VKNA
None None 3 4.7% 4YPSA
DFGin BLAminus 2 3.1% AF-P04629-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NTRK1_HUMAN AF-P04629-K1A P04629 502 791 796.0 No_ligand No_ligand Active DFGin 7.164 14.372 BLAminus -126.4, -168.05 48.95, 78.27 -90.55, 12.64 289.56, 90.19 -61.03, -31.73 in-in in 8.978 Saltbr-in 2.881 HRD-in -72.77, -40.89 66.37, -21.2 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.51, 136.89 APE9-dihe-in -128.62, 136.22 APE8-dihe-in -78.96, 62.95 APE8-rot-na 34.87 APE67-dihe-in -73.77, -14.24 -40.1, -43.39 APE12-dist-na 14.711 APE11-dist-na 8.671 APE10-dist-na 10.011 APE9-dist-in 6.907 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[510, 783]] 1.0 AF-P04629-K1 Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN AF-P04629-K3A P04629 502 791 796.0 No_ligand No_ligand Active DFGin 7.323 14.152 BLAminus -129.69, -166.67 52.24, 63.22 -79.66, 9.74 296.19, 93.99 -60.65, -28.88 in-in in 9.223 Saltbr-in 2.751 HRD-in -73.08, -44.78 68.09, -10.06 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.13, 137.21 APE9-dihe-in -116.97, 144.96 APE8-dihe-in -76.62, 65.71 APE8-rot-na 37.35 APE67-dihe-in -74.52, -3.17 -47.64, -33.3 APE12-dist-na 14.48 APE11-dist-na 9.213 APE10-dist-na 11.217 APE9-dist-in 6.744 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[510, 783]] 1.0 AF-P04629-K3 Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.7 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KVTA P04629 501 787 796.0 YMX:60801 Type1 Inactive DFGin 6.09 14.64 ABAminus -123.93, -0.04 -156.57, 153.18 -119.59, 34.13 294.14, 82.51 42.35, 42.02 in-in in 9.206 Saltbr-in 3.066 HRD-in -72.66, -50.09 79.9, -10.34 in-out-in SNCioi out-in ActLoopNT-out 14.246 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.61, 123.93 APE9-dihe-in -109.81, 133.19 APE8-dihe-in -81.57, 68.18 APE8-rot-na 37.74 APE67-dihe-in -59.58, -23.04 -58.72, -36.84 APE12-dist-na 12.336 APE11-dist-na 12.164 APE10-dist-na 10.118 APE9-dist-in 7.101 None None None XRAY 2.45 0.195 0.239 A 293 283 4 0 0 0 [[510, 783]] 1.0 5kvt Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6IQNB P04629 502 788 796.0 AQ6:60801 Type1 Inactive DFGin 6.802 15.004 ABAminus -105.93, -21.08 -155.49, 154.25 -121.75, -62.07 303.57, 79.9 179.93, 999.0 out-out out 10.242 Saltbr-out 7.062 HRD-in -80.44, -51.29 82.75, -12.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.38 APE8-dihe-in -85.76, 64.75 APE8-rot-na 31.54 APE67-dihe-in -69.39, -18.06 -57.29, -35.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.637 None None None XRAY 2.54 0.228 0.287 B 296 257 30 0 0 18 [[510, 783]] 1.0 6iqn Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4YNEA P04629 502 793 796.0 4EK:60801 Type1 Inactive DFGin 6.462 14.412 ABAminus -116.57, -25.87 -138.59, 132.08 -91.61, -8.55 292.59, 93.64 65.27, 48.21 in-out in 9.954 Saltbr-out 4.23 HRD-out -88.11, 116.02 -91.0, 8.56 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.59, 116.87 APE9-dihe-in -104.89, 127.5 APE8-dihe-in -70.7, 65.57 APE8-rot-na 30.51 APE67-dihe-in -68.75, -18.3 -60.63, -34.72 APE12-dist-na 999.0 APE11-dist-na 12.241 APE10-dist-na 12.204 APE9-dist-in 6.75 None None None XRAY 2.023 0.185 0.216 A 303 276 16 0 0 9 [[510, 783]] 1.0 4yne Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4AOJA P04629 500 789 796.0 V4Z:900 Type1 Inactive DFGin 7.022 14.275 ABAminus -110.98, -17.61 -143.63, 144.58 -112.81, -7.22 297.76, 85.92 -118.46, 999.0 in-in in 9.553 Saltbr-in 2.943 HRD-in -75.58, -50.98 84.9, -17.33 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.46, 125.37 APE9-dihe-in -125.37, 131.86 APE8-dihe-in -79.47, 66.97 APE8-rot-na 31.18 APE67-dihe-in -64.32, -24.98 -57.7, -37.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.148 None None None XRAY 2.75 0.221 0.242 A 329 260 30 0 0 16 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4AOJC P04629 500 789 796.0 V4Z:900 Type1 Inactive DFGin 6.925 14.318 ABAminus -113.25, -25.61 -134.45, 155.26 -115.79, 26.54 295.12, 82.68 85.56, -93.23 in-out in 9.558 Saltbr-out 4.025 HRD-in -72.16, -45.71 73.74, -15.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.55 APE9-dihe-in -124.46, 135.84 APE8-dihe-in -82.75, 63.3 APE8-rot-na 24.35 APE67-dihe-in -63.5, -31.49 -48.92, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.541 APE9-dist-in 7.01 None None None XRAY 2.75 0.221 0.242 C 329 261 29 0 0 16 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 7VKNA P04629 502 794 796.0 7GI:60801 Type1 Inactive DFGin 5.984 13.017 ABAminus -115.39, -41.87 -131.41, 143.63 -111.24, 20.98 314.85, 71.2 75.66, -101.93 in-out in 9.383 Saltbr-out 4.916 HRD-out -83.04, 118.83 -102.62, 15.46 out-out-in SNCooi out-in ActLoopNT-out 12.754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.12, 137.74 APE9-dihe-in -119.62, 140.33 APE8-dihe-in -80.18, 72.83 APE8-rot-na 34.86 APE67-dihe-in -69.38, -23.62 -70.62, -21.09 APE12-dist-na 11.42 APE11-dist-na 12.792 APE10-dist-na 11.858 APE9-dist-in 6.585 G595R None None XRAY 2.7 0.186 0.256 A 326 292 1 0 0 1 [[510, 783]] 1.0 7vkn Homo sapiens TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4PMTA P04629 501 787 796.0 31Y:60801 Type1 Inactive DFGin 6.131 14.794 None -112.67, -17.01 -137.68, 145.04 -146.35, 999.0 322.04, 80.71 999.0, 999.0 in-out in 9.806 Saltbr-out 3.633 HRD-in -75.33, -51.24 80.98, -15.04 out-out-in SNCooi out-in ActLoopNT-out 15.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.06, 128.33 APE9-dihe-in -117.66, 131.56 APE8-dihe-in -80.54, 63.91 APE8-rot-na 31.59 APE67-dihe-in -62.62, -22.15 -50.58, -36.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.218 None None None XRAY 2.1 0.186 0.209 A 291 269 18 0 0 5 [[510, 783]] 1.0 4pmt Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5I8AA P04629 501 787 796.0 69C:60801 Type1 Inactive DFGin 6.738 14.39 None -97.16, -113.31 -48.28, 144.89 -102.36, 10.49 289.66, 94.22 178.06, 999.0 in-in in 9.629 Saltbr-in 3.266 HRD-in -70.07, -53.33 85.54, -20.79 in-out-in SNCioi out-in ActLoopNT-out 17.127 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.82, 123.59 APE9-dihe-in -112.87, 128.48 APE8-dihe-in -77.41, 62.86 APE8-rot-na 29.5 APE67-dihe-in -66.17, -22.6 -48.87, -35.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.245 None None None XRAY 2.33 0.18 0.209 A 296 266 21 0 0 4 [[510, 783]] 1.0 5i8a Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6IQNA P04629 502 790 796.0 AQ6:60801 Type1 Inactive DFGin 7.14 15.11 None -103.61, -29.7 -117.2, -70.49 62.55, 999.0 316.84, 95.5 999.0, 999.0 in-out in 9.792 Saltbr-out 4.81 HRD-in -72.08, -53.46 85.54, -25.89 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.52, 109.29 APE9-dihe-in -102.41, 128.27 APE8-dihe-in -77.64, 69.03 APE8-rot-na 26.82 APE67-dihe-in -69.77, -22.47 -58.81, -29.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.33 None None None XRAY 2.54 0.228 0.287 A 296 271 18 0 0 12 [[510, 783]] 1.0 6iqn Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 7XAFA P04629 498 796 796.0 FKT:801 Type1 Inactive DFGin 10.973 15.53 None -141.15, 137.13 74.8, 177.08 49.53, -82.17 307.2, 139.07 -1.5, 80.75 in-out in 9.481 Saltbr-out 3.701 HRD-out -81.39, 105.98 -86.3, -0.43 out-out-in SNCooi out-in ActLoopNT-out 15.438 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.83, 144.52 APE9-dihe-in -128.89, 123.51 APE8-dihe-in -76.16, 66.1 APE8-rot-na 29.0 APE67-dihe-in -71.14, -21.57 -60.15, -25.01 APE12-dist-na 15.023 APE11-dist-na 14.335 APE10-dist-na 10.417 APE9-dist-in 7.363 None None None XRAY 3.001 0.25 0.299 A 299 287 12 0 0 0 [[510, 783]] 1.0 7xaf Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6J5LA P04629 502 790 796.0 B9C:60801 Type1 Inactive DFGin 6.127 13.793 None -112.0, -17.65 -146.4, 142.64 -117.9, -119.21 307.69, 78.13 -102.52, 999.0 in-in in 9.345 Saltbr-in 3.422 HRD-out -88.88, 113.33 -93.5, 4.21 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.51, 126.2 APE9-dihe-in -111.04, 133.44 APE8-dihe-in -88.74, 66.42 APE8-rot-na 38.43 APE67-dihe-in -63.3, -23.33 -52.55, -36.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.933 None None None XRAY 2.3 0.224 0.251 A 303 278 11 0 0 7 [[510, 783]] 1.0 6j5l Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PMEB P04629 499 791 796.0 OOY:802 Type1 Inactive DFGin 8.041 12.775 None -108.23, 50.17 -34.62, -93.7 -97.7, 157.35 268.23, 140.64 158.45, -156.12 in-out in 9.687 Saltbr-out 4.362 HRD-in -75.61, -49.56 82.71, -16.4 out-out-none SNCoon out-none ActLoopNT-out 15.678 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 119.79 APE9-dihe-in -136.64, 129.71 APE8-dihe-in -72.47, 62.28 APE8-rot-na 30.59 APE67-dihe-in -74.1, -16.42 -50.47, -31.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.757 APE9-dist-in 7.019 None SEP677 SEP677 XRAY 3.0 0.259 0.315 B 311 271 22 0 0 5 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.329 15.102 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.698 Saltbr-in 3.253 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.495 None None None XRAY 2.864 0.22 0.277 A 320 264 32 0 0 19 [[510, 783]] 1.0 9dai Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 7VKOA P04629 502 793 796.0 7GI:60801 Type1 Inactive DFGin 6.331 13.793 None -121.29, -23.19 -130.55, 158.61 -131.43, -91.62 300.81, 84.28 -89.58, -178.74 in-out in 9.271 Saltbr-out 4.844 HRD-out -83.55, 115.94 -93.33, 10.49 out-out-in SNCooi out-in ActLoopNT-out 15.213 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.01, 135.08 APE9-dihe-in -120.4, 150.84 APE8-dihe-in -84.95, 78.96 APE8-rot-na 37.61 APE67-dihe-in -53.21, -25.59 -47.58, -54.99 APE12-dist-na 10.738 APE11-dist-na 11.773 APE10-dist-na 9.731 APE9-dist-in 6.348 None None None XRAY 2.9 0.188 0.267 A 326 292 0 0 0 0 [[510, 783]] 1.0 7vko Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4AOJB P04629 500 791 796.0 V4Z:900 Type1 Inactive DFGin 7.101 14.487 None -112.8, -14.1 -146.85, 148.75 -118.66, 999.0 304.25, 74.79 999.0, 999.0 in-out in 9.774 Saltbr-out 3.783 HRD-in -81.07, -46.03 78.05, -27.65 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.18 APE8-dihe-in -83.87, 63.88 APE8-rot-na 24.55 APE67-dihe-in -64.26, -27.58 -47.61, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.237 None None None XRAY 2.75 0.221 0.242 B 329 258 34 0 0 19 [[510, 783]] 1.0 4aoj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6DKGA P04629 500 796 796.0 22L:801,GO7:802 Allosteric,Type2 Inactive DFGout 15.455 10.885 BBAminus -129.84, -153.68 -169.97, 108.79 -76.62, -30.73 288.52, 72.75 116.03, 999.0 in-out in 9.851 Saltbr-out 5.109 HRD-in -69.9, -49.64 79.4, -12.32 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.62, 109.43 APE9-dihe-in -100.38, 134.76 APE8-dihe-in -83.29, 59.25 APE8-rot-na 32.8 APE67-dihe-in -64.09, -21.64 -42.0, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.357 None None None XRAY 2.53 0.189 0.225 A 320 276 21 0 0 9 [[510, 783]] 1.0 6dkg Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6DKIA P04629 500 796 796.0 22L:801,GOD:802 Allosteric,Type2 Inactive DFGout 15.657 10.339 BBAminus -138.27, -151.87 -172.63, 116.91 -81.37, -9.66 281.96, 77.97 75.28, 999.0 in-out in 9.895 Saltbr-out 4.913 HRD-in -65.87, -50.46 77.43, -14.55 out-out-in SNCooi out-in ActLoopNT-out 16.615 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.45, 122.12 APE9-dihe-in -117.82, 128.28 APE8-dihe-in -76.01, 65.16 APE8-rot-na 30.62 APE67-dihe-in -68.36, -18.63 -49.98, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.307 None None None XRAY 2.11 0.186 0.227 A 320 279 18 0 0 6 [[510, 783]] 1.0 6dki Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6D1ZA P04629 483 796 796.0 FQD:801,FQM:803 Allosteric,Type3 Inactive DFGout 12.567 7.366 BBAminus 167.82, 150.89 -150.57, 163.47 -100.59, 23.19 306.23, 116.03 65.85, 23.26 in-out in 9.854 Saltbr-out 6.197 HRD-in -66.06, -47.82 80.23, -21.06 out-out-in SNCooi out-in ActLoopNT-out 15.302 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.79, 107.46 APE9-dihe-in -108.68, 135.71 APE8-dihe-in -79.15, 66.52 APE8-rot-na 33.74 APE67-dihe-in -68.05, -19.94 -54.02, -36.77 APE12-dist-na 999.0 APE11-dist-na 14.491 APE10-dist-na 10.819 APE9-dist-in 7.253 None None None XRAY 1.87 0.18 0.21 A 320 290 16 0 0 4 [[510, 783]] 1.0 6d1z Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 7VKMA P04629 502 795 796.0 No_ligand No_ligand Inactive DFGout 12.323 7.432 BBAminus 176.27, 165.41 -156.55, 175.73 -110.4, 8.5 305.75, 118.24 88.56, 16.82 in-out in 9.568 Saltbr-out 4.915 HRD-in -72.61, -55.29 84.51, -23.12 out-out-in SNCooi out-in ActLoopNT-out 15.661 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.68, 125.36 APE9-dihe-in -117.44, 136.53 APE8-dihe-in -89.28, 75.32 APE8-rot-na 30.03 APE67-dihe-in -68.93, -24.54 -65.78, -30.21 APE12-dist-na 14.249 APE11-dist-na 15.511 APE10-dist-na 10.87 APE9-dist-in 7.207 G595R None None XRAY 2.55 0.202 0.257 A 326 294 0 0 0 0 [[510, 783]] 1.0 7vkm Homo sapiens TYR_NTRK1_HUMAN TYR 1.3e-98 335.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4PMPA P04629 501 787 796.0 31W:60801 Type1 Inactive DFGout 15.486 10.55 BBAminus -133.03, -157.37 -173.03, 103.22 -69.9, -32.34 288.02, 70.73 77.22, -47.74 in-out in 9.568 Saltbr-out 4.647 HRD-in -67.48, -51.34 82.08, -14.32 out-out-in SNCooi out-in ActLoopNT-out 15.732 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.87, 121.14 APE9-dihe-in -118.75, 136.28 APE8-dihe-in -80.92, 64.59 APE8-rot-na 34.05 APE67-dihe-in -64.12, -19.76 -49.55, -38.41 APE12-dist-na 999.0 APE11-dist-na 13.915 APE10-dist-na 9.735 APE9-dist-in 7.19 None None None XRAY 1.8 0.166 0.185 A 291 276 11 0 0 3 [[510, 783]] 1.0 4pmp Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.708 6.583 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.447 Saltbr-out 5.851 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.748 APE11-dist-na 15.2 APE10-dist-na 10.681 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324 303 10 0 0 0 [[510, 783]] 1.0 5h3q Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4PMMA P04629 501 787 796.0 31V:60801 Type2 Inactive DFGout 12.146 10.95 BBAminus -133.43, -162.51 -156.69, 94.05 -92.35, -31.82 309.48, 143.39 59.02, -8.13 in-out in 9.286 Saltbr-out 4.76 HRD-in -72.63, -53.5 82.36, -15.27 out-out-in SNCooi out-in ActLoopNT-out 16.095 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.51, 115.08 APE9-dihe-in -105.75, 129.0 APE8-dihe-in -80.23, 63.87 APE8-rot-na 30.48 APE67-dihe-in -66.31, -17.94 -46.68, -40.06 APE12-dist-na 13.786 APE11-dist-na 15.797 APE10-dist-na 10.76 APE9-dist-in 7.145 None None None XRAY 2.0 0.166 0.199 A 291 281 6 0 0 0 [[510, 783]] 1.0 4pmm Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5JFSA P04629 502 793 796.0 6K0:64000 Type2 Inactive DFGout 12.527 10.983 BBAminus -135.78, -160.84 -157.76, 107.91 -107.26, 3.47 322.34, 129.58 106.13, 999.0 in-in in 9.81 Saltbr-in 2.888 HRD-in -71.87, -49.52 79.25, -12.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.58 APE8-dihe-in -83.43, 60.43 APE8-rot-na 33.02 APE67-dihe-in -63.9, -20.6 -49.99, -40.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.565 None None None XRAY 2.07 0.171 0.191 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfs Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5JFVA P04629 502 793 796.0 6K1:64000 Type2 Inactive DFGout 12.638 11.028 BBAminus -141.43, -159.86 -155.63, 106.71 -102.51, 5.29 321.04, 131.31 88.83, 999.0 out-out out 10.053 Saltbr-out 3.842 HRD-in -71.26, -49.89 78.63, -12.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.24 APE8-dihe-in -81.16, 59.69 APE8-rot-na 33.1 APE67-dihe-in -63.0, -20.76 -49.39, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.533 None None None XRAY 1.59 0.173 0.192 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfv Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5JFWA P04629 502 793 796.0 6K2:64000 Type2 Inactive DFGout 12.659 11.195 BBAminus -133.87, -158.13 -156.47, 107.62 -101.73, 2.97 321.78, 129.01 71.48, 999.0 out-out out 10.196 Saltbr-out 8.11 HRD-in -70.93, -50.56 80.08, -11.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.64 APE8-dihe-in -79.87, 59.55 APE8-rot-na 31.09 APE67-dihe-in -62.34, -22.4 -47.37, -43.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 None None None XRAY 1.52 0.18 0.209 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfw Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5JFXA P04629 502 793 796.0 6K4:64000 Type2 Inactive DFGout 12.748 11.04 BBAminus -133.96, -162.47 -154.94, 107.94 -100.19, 17.72 319.82, 130.69 65.97, 999.0 out-in out 10.117 Saltbr-in 3.479 HRD-in -70.26, -49.25 76.75, -14.14 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.45 APE8-dihe-in -81.06, 57.38 APE8-rot-na 33.47 APE67-dihe-in -62.32, -20.75 -46.26, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.65 None None None XRAY 1.63 0.203 0.232 A 308 264 28 0 0 18 [[510, 783]] 1.0 5jfx Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6DKWA P04629 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.797 11.147 BBAminus -132.36, -152.04 -163.87, 118.82 -86.57, 0.12 282.19, 82.2 87.26, 999.0 out-out out 10.036 Saltbr-out 7.707 HRD-in -70.19, -47.29 72.43, -13.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.7 APE8-dihe-in -77.96, 56.47 APE8-rot-na 32.78 APE67-dihe-in -69.34, -24.62 -48.56, -36.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.457 None None None XRAY 2.91 0.233 0.262 A 308 271 21 0 0 18 [[510, 783]] 1.0 6dkw Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6DKWB P04629 502 793 796.0 GXA:60801 Type2 Inactive DFGout 15.312 11.664 BBAminus -137.72, -157.97 -167.56, 133.61 -110.92, -23.72 305.39, 77.76 119.48, 999.0 in-out in 9.806 Saltbr-out 7.952 HRD-in -71.64, -50.67 77.06, -19.15 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.56, 120.27 APE9-dihe-in -83.42, 115.11 APE8-dihe-in -79.02, 56.72 APE8-rot-na 32.67 APE67-dihe-in -66.06, -29.18 -49.12, -39.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.891 None None None XRAY 2.91 0.233 0.262 B 308 263 29 0 0 16 [[510, 783]] 1.0 6dkw Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PL2A P04629 499 795 796.0 OOM:801 Type2 Inactive DFGout 12.612 11.733 BBAminus -133.35, -162.35 -156.24, 113.82 -105.83, 45.09 316.55, 125.06 63.21, -157.53 in-out in 8.738 Saltbr-out 4.349 HRD-in -67.21, -55.46 83.15, -23.62 out-out-in SNCooi out-in ActLoopNT-out 18.179 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.48, 132.06 APE9-dihe-in -120.18, 125.99 APE8-dihe-in -79.18, 69.41 APE8-rot-na 32.0 APE67-dihe-in -66.97, -17.29 -57.88, -39.56 APE12-dist-na 10.501 APE11-dist-na 10.402 APE10-dist-na 5.73 APE9-dist-in 7.3 None SEP677 SEP677 XRAY 2.59 0.202 0.274 A 311 297 0 0 0 0 [[510, 783]] 1.0 6pl2 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 7XBIA P04629 497 795 796.0 CVY:801 Type2 Inactive DFGout 14.107 10.796 BBAminus -137.82, -164.37 -150.04, 97.3 -71.59, -9.66 278.32, 66.5 74.67, 31.7 in-out in 9.747 Saltbr-out 4.318 HRD-in -82.22, -63.27 93.82, -12.28 out-out-in SNCooi out-in ActLoopNT-out 18.423 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.41, 123.03 APE9-dihe-in -113.59, 129.96 APE8-dihe-in -80.4, 65.23 APE8-rot-na 30.24 APE67-dihe-in -62.07, -20.59 -54.97, -38.49 APE12-dist-na 10.546 APE11-dist-na 11.082 APE10-dist-na 6.243 APE9-dist-in 7.206 None None None XRAY 2.16 0.194 0.246 A 311 299 0 0 0 0 [[510, 783]] 1.0 7xbi Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 8J5XA P04629 500 795 796.0 A4U:801 Type2 Inactive DFGout 13.036 10.369 BBAminus -130.91, -158.27 -162.66, 108.46 -93.68, 5.06 291.9, 93.65 78.16, -167.64 in-in in 8.889 Saltbr-in 2.61 HRD-in -70.53, -55.33 83.0, -11.79 in-out-in SNCioi out-in ActLoopNT-out 18.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.89, 140.84 APE9-dihe-in -129.21, 130.11 APE8-dihe-in -79.69, 64.42 APE8-rot-na 33.0 APE67-dihe-in -65.79, -20.2 -56.52, -34.65 APE12-dist-na 13.297 APE11-dist-na 8.895 APE10-dist-na 6.03 APE9-dist-in 7.218 G595R None None XRAY 2.092 0.184 0.22 A 299 296 0 0 0 0 [[510, 783]] 1.0 8j5x Homo sapiens TYR_NTRK1_HUMAN TYR 9.7e-99 335.8 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PL4A P04629 485 795 796.0 OO7:801 Type3 Inactive DFGout 12.331 6.751 BBAminus 163.32, 156.14 -161.4, 166.2 -103.41, 14.03 294.82, 105.0 75.38, 27.87 in-out in 9.548 Saltbr-out 6.947 HRD-in -67.83, -53.77 81.67, -11.19 out-out-in SNCooi out-in ActLoopNT-out 15.677 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.06, 119.89 APE9-dihe-in -108.16, 133.15 APE8-dihe-in -81.07, 64.06 APE8-rot-na 35.11 APE67-dihe-in -63.69, -22.36 -54.01, -37.98 APE12-dist-na 13.774 APE11-dist-na 15.065 APE10-dist-na 10.803 APE9-dist-in 7.259 None SEP677 SEP677 XRAY 2.06 0.202 0.239 A 311 299 3 0 0 0 [[510, 783]] 1.0 6pl4 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6D20A P04629 482 796 796.0 FQD:801,FQG:802 Allosteric,Type3 Inactive DFGout 12.121 7.682 None 160.41, 153.19 -151.74, 163.05 -104.33, 22.77 307.7, 135.7 70.27, 21.28 out-out out 10.011 Saltbr-out 4.832 HRD-in -65.64, -51.3 81.74, -20.54 out-out-in SNCooi out-in ActLoopNT-out 15.27 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.06, 110.16 APE9-dihe-in -105.1, 135.52 APE8-dihe-in -82.75, 65.28 APE8-rot-na 34.64 APE67-dihe-in -60.75, -21.14 -48.61, -41.93 APE12-dist-na 999.0 APE11-dist-na 15.38 APE10-dist-na 10.975 APE9-dist-in 7.221 None None None XRAY 1.94 0.172 0.207 A 320 296 13 0 0 2 [[510, 783]] 1.0 6d20 Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4F0IA P04629 501 790 796.0 No_ligand No_ligand Inactive DFGout 12.724 6.541 None 168.4, 147.46 -150.91, -178.97 -114.84, 17.84 296.33, 102.98 77.14, 17.47 out-out out 10.072 Saltbr-out 3.783 HRD-in -70.62, -54.37 86.42, -21.28 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.87, 117.07 APE9-dihe-in -123.33, 147.3 APE8-dihe-in -80.93, 68.13 APE8-rot-na 33.21 APE67-dihe-in -63.68, -22.55 -54.54, -38.97 APE12-dist-na 18.887 APE11-dist-na 14.675 APE10-dist-na 10.919 APE9-dist-in 7.231 None None None XRAY 2.302 0.185 0.241 A 300 284 6 0 0 0 [[510, 783]] 1.0 4f0i Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4F0IB P04629 501 794 796.0 No_ligand No_ligand Inactive DFGout 12.543 7.011 None 166.76, 148.15 -155.18, 178.64 -114.64, 15.88 300.05, 104.73 73.51, 23.99 in-out in 9.546 Saltbr-out 3.613 HRD-in -74.85, -50.62 80.22, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.499 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.15, 119.22 APE9-dihe-in -115.7, 131.68 APE8-dihe-in -79.13, 66.63 APE8-rot-na 32.83 APE67-dihe-in -65.29, -20.15 -62.09, -33.78 APE12-dist-na 15.648 APE11-dist-na 15.205 APE10-dist-na 10.671 APE9-dist-in 7.475 None None None XRAY 2.302 0.185 0.241 B 300 294 0 0 0 0 [[510, 783]] 1.0 4f0i Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4GT5A P04629 498 793 796.0 No_ligand No_ligand Inactive DFGout 12.604 7.347 None 159.19, 156.78 -162.75, 171.4 -109.98, 15.11 307.11, 107.92 73.58, 34.63 in-none in 9.757 Saltbr-none 999.0 HRD-in -59.3, -59.24 86.11, -5.83 none-out-in SNCnoi out-in ActLoopNT-out 15.797 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.6, 126.13 APE9-dihe-in -108.71, 129.99 APE8-dihe-in -77.33, 65.58 APE8-rot-na 28.73 APE67-dihe-in -65.65, -17.34 -57.96, -37.68 APE12-dist-na 15.147 APE11-dist-na 15.37 APE10-dist-na 11.229 APE9-dist-in 7.444 None None None XRAY 2.398 0.204 0.248 A 306 290 6 0 0 0 [[510, 783]] 1.0 4gt5 Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6D22A P04629 502 794 796.0 No_ligand No_ligand Inactive DFGout 12.606 7.143 None 175.88, 158.7 -166.39, 174.44 -112.95, 15.95 304.35, 111.16 86.04, 4.07 in-out in 9.613 Saltbr-out 3.848 HRD-in -74.57, -54.54 85.84, -16.79 out-out-in SNCooi out-in ActLoopNT-out 15.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.68, 117.35 APE9-dihe-in -107.64, 132.88 APE8-dihe-in -74.3, 62.56 APE8-rot-na 38.38 APE67-dihe-in -63.87, -17.11 -48.79, -48.38 APE12-dist-na 13.895 APE11-dist-na 15.264 APE10-dist-na 10.95 APE9-dist-in 7.577 None None None XRAY 2.46 0.178 0.236 A 307 293 0 0 0 0 [[510, 783]] 1.0 6d22 Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6DKBA P04629 501 796 796.0 FKY:4000 Type1 Inactive DFGout 15.332 10.748 None -132.31, -154.04 -173.63, 117.2 -89.02, -138.07 293.55, 87.71 -145.33, 999.0 out-in out 10.015 Saltbr-in 3.343 HRD-in -63.64, -46.04 75.89, -18.83 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 136.46 APE9-dihe-in -131.13, 141.89 APE8-dihe-in -81.0, 68.63 APE8-rot-na 33.49 APE67-dihe-in -61.76, -21.1 -51.01, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.273 None None None XRAY 2.68 0.217 0.245 A 320 272 24 0 0 11 [[510, 783]] 1.0 6dkb Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMOA P04629 500 796 796.0 6UM:60901 Type1 Inactive DFGout 12.319 11.374 None -138.6, -165.07 -158.74, 98.32 -111.51, -171.02 340.4, 114.97 156.89, 999.0 out-out out 10.631 Saltbr-out 6.316 HRD-in -66.47, -58.38 85.91, -20.7 out-out-in SNCooi out-in ActLoopNT-out 17.221 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.17, 145.62 APE9-dihe-in -124.84, 130.96 APE8-dihe-in -87.13, 68.95 APE8-rot-na 25.74 APE67-dihe-in -56.92, -24.53 -50.66, -48.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.161 None None None XRAY 2.67 0.196 0.243 A 329 290 7 0 0 2 [[510, 783]] 1.0 5kmo Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4PMSA P04629 501 787 796.0 31X:60801 Type1.5_Back Inactive DFGout 12.026 11.607 None -132.53, -155.25 -159.75, 97.5 -105.99, 141.7 318.1, 112.95 -75.26, -27.15 in-out in 9.471 Saltbr-out 6.462 HRD-in -62.95, -59.22 88.04, -25.42 out-out-in SNCooi out-in ActLoopNT-out 15.92 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 110.83 APE9-dihe-in -104.11, 139.32 APE8-dihe-in -84.02, 66.3 APE8-rot-na 28.87 APE67-dihe-in -67.29, -19.63 -45.69, -39.43 APE12-dist-na 17.385 APE11-dist-na 17.142 APE10-dist-na 12.483 APE9-dist-in 7.233 None None None XRAY 2.8 0.168 0.24 A 291 279 8 0 0 2 [[510, 783]] 1.0 4pms Homo sapiens TYR_NTRK1_HUMAN TYR 1.6e-100 341.6 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 8J5WA P04629 485 795 796.0 A4U:801 Type2 Inactive DFGout 14.106 9.904 None -124.93, -156.11 -165.36, 86.03 -59.52, 147.81 290.47, 86.44 107.07, -85.27 in-out in 9.572 Saltbr-out 6.072 HRD-out -97.68, 106.96 -81.54, 7.53 out-out-in SNCooi out-in ActLoopNT-out 16.096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.59, 129.11 APE9-dihe-in -117.85, 126.3 APE8-dihe-in -74.82, 63.31 APE8-rot-na 31.0 APE67-dihe-in -67.5, -17.44 -56.64, -33.03 APE12-dist-na 15.441 APE11-dist-na 16.069 APE10-dist-na 11.4 APE9-dist-in 7.04 F589L None None XRAY 2.28 0.222 0.266 A 313 298 4 0 0 0 [[510, 783]] 1.0 8j5w Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 340.9 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 8J61A P04629 499 795 796.0 A0X:801 Type2 Inactive DFGout 13.23 11.155 None -134.57, -179.08 -139.19, 96.75 -83.33, 178.03 307.14, 171.93 171.37, -120.57 out-out out 10.109 Saltbr-out 6.455 HRD-in -80.6, -37.38 66.53, -21.87 out-out-in SNCooi out-in ActLoopNT-out 15.574 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -141.71, 130.82 APE9-dihe-in -115.65, 127.68 APE8-dihe-in -74.28, 70.21 APE8-rot-na 29.28 APE67-dihe-in -73.67, -7.76 -58.39, -28.44 APE12-dist-na 16.775 APE11-dist-na 15.162 APE10-dist-na 11.578 APE9-dist-in 6.997 None None None XRAY 3.051 0.209 0.255 A 299 291 6 0 0 0 [[510, 783]] 1.0 8j61 Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 8J63A P04629 500 796 796.0 A6X:801 Type2 Inactive DFGout 13.758 10.314 None -148.15, -172.21 -147.6, 96.08 -75.43, 162.83 293.22, 106.5 105.33, -112.14 in-out in 9.819 Saltbr-out 4.245 HRD-in -78.37, -44.48 66.44, -4.46 out-out-in SNCooi out-in ActLoopNT-out 15.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.3, 149.87 APE9-dihe-in -128.22, 125.62 APE8-dihe-in -76.56, 58.46 APE8-rot-na 30.42 APE67-dihe-in -72.95, -14.47 -58.85, -23.58 APE12-dist-na 17.283 APE11-dist-na 16.106 APE10-dist-na 11.849 APE9-dist-in 7.257 None None None XRAY 3.001 0.233 0.289 A 299 291 6 0 0 0 [[510, 783]] 1.0 8j63 Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5WR7A P04629 489 792 796.0 RCH:801 Type2 Inactive DFGout 14.663 8.431 None -131.73, -148.47 -166.21, 161.63 -141.28, 117.22 276.93, 88.17 -99.45, -3.58 out-out out 10.191 Saltbr-out 7.425 HRD-in -69.6, -49.89 70.97, 2.48 out-out-in SNCooi out-in ActLoopNT-out 18.125 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.65, 116.34 APE9-dihe-in -122.66, 128.76 APE8-dihe-in -78.54, 68.52 APE8-rot-na 32.36 APE67-dihe-in -68.82, -19.66 -50.73, -45.45 APE12-dist-na 999.0 APE11-dist-na 14.927 APE10-dist-na 10.089 APE9-dist-in 7.042 None SEP677 SEP677 XRAY 2.76 0.208 0.234 A 304 302 2 0 0 2 [[510, 783]] 1.0 5wr7 Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PL1A P04629 500 795 796.0 OOJ:801 Type2 Inactive DFGout 12.202 11.545 None -140.12, -163.59 -151.72, 95.42 -94.74, 114.97 323.02, 137.75 -51.78, -31.38 in-out in 9.537 Saltbr-out 4.254 HRD-in -65.5, -55.98 80.9, -7.13 out-out-in SNCooi out-in ActLoopNT-out 16.016 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.78, 119.43 APE9-dihe-in -106.09, 130.79 APE8-dihe-in -83.67, 66.03 APE8-rot-na 34.24 APE67-dihe-in -63.93, -22.81 -49.57, -43.95 APE12-dist-na 999.0 APE11-dist-na 15.228 APE10-dist-na 10.758 APE9-dist-in 7.134 None SEP677 SEP677 XRAY 2.03 0.22 0.26 A 311 290 6 0 0 3 [[510, 783]] 1.0 6pl1 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PL3A P04629 500 795 796.0 OOD:801 Type2 Inactive DFGout 11.564 10.91 None -143.28, -158.28 -155.92, 104.62 -110.35, 130.24 309.4, 131.25 -70.56, -23.22 in-out in 9.269 Saltbr-out 3.683 HRD-in -79.21, -48.25 72.7, -2.08 out-out-in SNCooi out-in ActLoopNT-out 16.474 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.4, 114.8 APE9-dihe-in -102.82, 125.91 APE8-dihe-in -81.39, 70.95 APE8-rot-na 32.5 APE67-dihe-in -65.12, -18.02 -56.45, -36.14 APE12-dist-na 15.256 APE11-dist-na 16.285 APE10-dist-na 11.683 APE9-dist-in 7.215 None None None XRAY 3.0 0.211 0.272 A 311 291 5 0 0 0 [[510, 783]] 1.0 6pl3 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PMAA P04629 500 795 796.0 OQS:801 Type2 Inactive DFGout 12.122 11.277 None -135.79, -172.95 -145.14, 102.3 -103.72, 124.51 321.1, 137.33 -54.09, -40.43 in-in in 9.047 Saltbr-in 2.591 HRD-in -75.81, -50.56 78.93, -17.98 in-out-in SNCioi out-in ActLoopNT-out 16.09 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -134.69, 117.23 APE9-dihe-in -107.06, 120.83 APE8-dihe-in -77.63, 65.04 APE8-rot-na 27.44 APE67-dihe-in -72.95, -15.51 -57.1, -33.54 APE12-dist-na 15.911 APE11-dist-na 15.668 APE10-dist-na 10.999 APE9-dist-in 7.264 None SEP677 SEP677 XRAY 2.53 0.209 0.266 A 311 290 6 0 0 0 [[510, 783]] 1.0 6pma Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PMBA P04629 500 795 796.0 OQM:801 Type2 Inactive DFGout 11.66 11.672 None -132.37, -159.76 -148.31, 103.43 -105.33, 151.54 318.17, 135.0 -87.93, -24.35 in-in in 9.175 Saltbr-in 3.46 HRD-in -70.6, -56.1 77.89, -14.23 in-out-in SNCioi out-in ActLoopNT-out 16.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.62, 125.62 APE9-dihe-in -118.02, 123.95 APE8-dihe-in -78.96, 65.2 APE8-rot-na 32.2 APE67-dihe-in -67.87, -21.55 -67.55, -29.76 APE12-dist-na 15.649 APE11-dist-na 16.578 APE10-dist-na 11.695 APE9-dist-in 7.186 None None None XRAY 2.81 0.219 0.282 A 311 288 8 0 0 0 [[510, 783]] 1.0 6pmb Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PMCA P04629 500 795 796.0 OQJ:801 Type2 Inactive DFGout 11.807 11.813 None -132.04, -168.64 -145.63, 90.01 -97.69, 142.15 324.37, 130.77 -66.35, -36.3 in-in in 9.651 Saltbr-in 3.527 HRD-in -82.16, -55.48 89.25, -24.57 in-out-in SNCioi out-in ActLoopNT-out 15.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.7, 118.63 APE9-dihe-in -108.33, 130.52 APE8-dihe-in -80.54, 62.41 APE8-rot-na 37.39 APE67-dihe-in -54.69, -23.0 -49.98, -41.68 APE12-dist-na 14.154 APE11-dist-na 15.681 APE10-dist-na 11.236 APE9-dist-in 7.226 None SEP677 SEP677 XRAY 2.19 0.25 0.298 A 311 289 7 0 0 0 [[510, 783]] 1.0 6pmc Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6NSPA P04629 500 795 796.0 L0P:801 Type3 Inactive DFGout 12.341 6.918 None 147.69, 153.73 -147.15, -178.06 -113.86, 11.77 292.26, 110.9 67.54, 37.24 in-out in 9.506 Saltbr-out 9.102 HRD-in -80.74, -60.67 84.66, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.69 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -135.01, 112.02 APE9-dihe-in -104.87, 129.45 APE8-dihe-in -77.35, 65.98 APE8-rot-na 35.66 APE67-dihe-in -61.95, -17.33 -58.27, -39.42 APE12-dist-na 13.388 APE11-dist-na 15.055 APE10-dist-na 10.661 APE9-dist-in 7.371 None None None XRAY 2.31 0.192 0.255 A 297 293 3 0 0 0 [[510, 783]] 1.0 6nsp Homo sapiens TYR_NTRK1_HUMAN TYR 1.7e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6NPTA P04629 491 795 796.0 KWY:801 Type3 Inactive DFGout 12.438 7.501 None 158.18, 155.8 -152.05, 169.87 -107.1, 19.78 311.07, 121.3 72.87, 27.1 out-out out 10.008 Saltbr-out 5.238 HRD-in -70.4, -52.75 80.08, -14.8 out-out-in SNCooi out-in ActLoopNT-out 15.592 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.83, 113.75 APE9-dihe-in -105.63, 131.16 APE8-dihe-in -80.28, 65.31 APE8-rot-na 34.86 APE67-dihe-in -61.58, -17.65 -56.43, -41.31 APE12-dist-na 14.426 APE11-dist-na 15.187 APE10-dist-na 10.648 APE9-dist-in 7.262 None SEP677 SEP677 XRAY 2.19 0.227 0.276 A 305 288 10 0 0 0 [[510, 783]] 1.0 6npt Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6NSSA P04629 485 795 796.0 L0M:801 Type3 Inactive DFGout 11.815 7.025 None 168.65, 153.78 -158.36, 171.84 -109.19, 24.3 297.57, 118.56 67.82, 28.96 in-out in 9.528 Saltbr-out 5.666 HRD-in -90.15, -59.03 81.79, -5.07 out-out-in SNCooi out-in ActLoopNT-out 16.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.54, 111.04 APE9-dihe-in -105.46, 130.52 APE8-dihe-in -80.81, 65.09 APE8-rot-na 33.3 APE67-dihe-in -66.94, -20.44 -58.3, -34.71 APE12-dist-na 13.068 APE11-dist-na 15.018 APE10-dist-na 10.687 APE9-dist-in 7.449 None None None XRAY 1.97 0.184 0.218 A 311 303 3 0 0 0 [[510, 783]] 1.0 6nss Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6D1YA P04629 481 796 796.0 FQJ:801 Type3 Inactive DFGout 12.673 6.856 None 169.8, 145.64 -149.42, -179.74 -114.54, 6.91 301.35, 101.16 76.21, 25.01 out-out out 10.052 Saltbr-out 5.442 HRD-in -65.07, -51.13 81.32, -20.97 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.27, 120.93 APE9-dihe-in -115.22, 138.24 APE8-dihe-in -78.51, 63.15 APE8-rot-na 29.74 APE67-dihe-in -66.08, -21.72 -48.21, -36.42 APE12-dist-na 999.0 APE11-dist-na 14.923 APE10-dist-na 10.709 APE9-dist-in 7.254 None None None XRAY 1.93 0.179 0.224 A 320 300 16 0 0 4 [[510, 783]] 1.0 6d1y Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMIA P04629 486 796 796.0 6UE:901 Type3 Inactive DFGout 12.102 7.293 None 161.69, 152.83 -154.44, 168.25 -105.96, 25.99 305.3, 125.58 65.11, 30.06 in-out in 9.486 Saltbr-out 6.201 HRD-in -70.33, -55.53 75.77, -9.09 out-out-in SNCooi out-in ActLoopNT-out 15.758 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.77, 111.89 APE9-dihe-in -104.52, 130.31 APE8-dihe-in -84.87, 65.08 APE8-rot-na 32.16 APE67-dihe-in -62.84, -22.31 -53.23, -38.24 APE12-dist-na 14.003 APE11-dist-na 15.654 APE10-dist-na 10.916 APE9-dist-in 7.529 None None None XRAY 1.87 0.21 0.247 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmi Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.602 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.714 Saltbr-in 2.772 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.107 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.016 APE11-dist-na 15.494 APE10-dist-na 11.096 APE9-dist-in 7.6 None None None XRAY 2.04 0.196 0.226 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMKA P04629 484 796 796.0 6UG:60901 Type3 Inactive DFGout 12.367 7.444 None 155.23, 152.12 -152.95, 175.79 -116.52, 20.57 308.16, 114.44 75.73, 21.77 in-out in 9.763 Saltbr-out 6.397 HRD-in -59.42, -51.85 75.91, -16.02 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.53, 119.76 APE9-dihe-in -107.42, 137.31 APE8-dihe-in -83.03, 63.78 APE8-rot-na 29.2 APE67-dihe-in -62.44, -17.14 -49.56, -42.83 APE12-dist-na 14.029 APE11-dist-na 15.416 APE10-dist-na 11.102 APE9-dist-in 7.25 None None None XRAY 2.24 0.227 0.281 A 329 302 5 0 0 0 [[510, 783]] 1.0 5kmk Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMMA P04629 484 796 796.0 6UJ:60901 Type3 Inactive DFGout 12.368 7.184 None 157.73, 155.5 -160.68, 165.48 -107.15, 26.91 307.0, 120.61 71.24, 15.54 in-out in 9.463 Saltbr-out 5.114 HRD-in -61.78, -57.27 78.61, -13.21 out-out-in SNCooi out-in ActLoopNT-out 15.663 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.76, 118.16 APE9-dihe-in -103.64, 132.25 APE8-dihe-in -82.99, 66.28 APE8-rot-na 32.09 APE67-dihe-in -66.37, -19.35 -53.37, -35.26 APE12-dist-na 13.548 APE11-dist-na 15.633 APE10-dist-na 11.207 APE9-dist-in 7.428 None None None XRAY 2.12 0.216 0.264 A 329 300 5 0 0 0 [[510, 783]] 1.0 5kmm Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMLA P04629 474 796 796.0 6UH:60901 Type3 Inactive DFGout 12.398 7.282 None 158.81, 154.45 -158.96, 169.19 -111.19, 29.55 308.68, 112.5 65.84, 21.76 in-out in 9.957 Saltbr-out 5.226 HRD-out -95.27, 113.75 -82.3, 1.42 out-out-in SNCooi out-in ActLoopNT-out 16.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.36, 117.18 APE9-dihe-in -101.68, 134.53 APE8-dihe-in -83.65, 62.57 APE8-rot-na 32.66 APE67-dihe-in -60.72, -23.67 -48.68, -40.28 APE12-dist-na 14.512 APE11-dist-na 15.25 APE10-dist-na 11.024 APE9-dist-in 7.223 None None None XRAY 2.01 0.204 0.232 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kml Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 5KMNA P04629 474 796 796.0 6UK:60901 Type3 Inactive DFGout 12.55 7.54 None 154.23, 154.5 -157.96, 168.93 -109.62, 31.32 313.55, 117.07 68.77, 19.82 in-out in 9.889 Saltbr-out 4.996 HRD-out -100.52, 112.12 -80.72, -0.22 out-out-in SNCooi out-in ActLoopNT-out 16.168 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.74, 114.86 APE9-dihe-in -100.75, 133.2 APE8-dihe-in -82.26, 61.08 APE8-rot-na 30.54 APE67-dihe-in -63.96, -19.55 -48.16, -39.69 APE12-dist-na 14.561 APE11-dist-na 15.367 APE10-dist-na 11.163 APE9-dist-in 7.323 None None None XRAY 2.14 0.195 0.222 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kmn Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 4YPSA P04629 502 790 796.0 4F6:60801 Type1 Inactive None 999.0 999.0 None -112.08, -158.35 4.87, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.117 Saltbr-out 9.125 HRD-out -86.73, 118.76 -94.8, 9.98 out-out-in SNCooi out-in ActLoopNT-out 17.743 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.0, 118.89 APE9-dihe-in -107.28, 139.4 APE8-dihe-in -81.62, 61.84 APE8-rot-na 34.18 APE67-dihe-in -64.91, -18.75 -58.48, -35.44 APE12-dist-na 999.0 APE11-dist-na 14.606 APE10-dist-na 10.321 APE9-dist-in 7.226 None None None XRAY 2.101 0.203 0.257 A 303 275 14 0 0 5 [[510, 783]] 1.0 4yps Homo sapiens TYR_NTRK1_HUMAN TYR 1.9e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PMEA P04629 500 788 796.0 OOY:802 Type1 Inactive None 11.274 14.866 None -103.64, 63.03 -6.61, -101.22 -108.6, -79.47 316.94, 83.99 80.48, -131.89 in-out in 9.65 Saltbr-out 4.197 HRD-in -82.82, -49.18 87.37, -21.9 out-out-in SNCooi out-in ActLoopNT-out 15.626 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.61, 116.38 APE9-dihe-in -119.8, 127.41 APE8-dihe-in -74.42, 64.21 APE8-rot-na 33.13 APE67-dihe-in -65.79, -8.94 -53.59, -37.65 APE12-dist-na 999.0 APE11-dist-na 14.349 APE10-dist-na 10.401 APE9-dist-in 7.124 None SEP677 SEP677 XRAY 3.0 0.259 0.315 A 311 268 21 0 0 3 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
NTRK1_HUMAN 6PMEC P04629 500 790 796.0 OOY:802 Type1 Inactive None 11.519 15.004 None -105.17, 39.93 27.01, -158.9 -47.91, -126.82 299.14, 109.98 111.56, -123.09 in-out in 9.672 Saltbr-out 4.961 HRD-in -71.5, -57.03 89.79, -15.29 out-out-in SNCooi out-in ActLoopNT-out 15.62 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.99, 111.57 APE9-dihe-in -114.5, 136.16 APE8-dihe-in -76.15, 63.17 APE8-rot-na 31.13 APE67-dihe-in -65.29, -26.47 -45.99, -41.18 APE12-dist-na 16.084 APE11-dist-na 14.681 APE10-dist-na 10.666 APE9-dist-in 6.964 None SEP677 SEP677 XRAY 3.0 0.259 0.315 C 311 274 17 0 0 2 [[510, 783]] 1.0 6pme Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor

TYR_NTRK1 (High affinity nerve growth factor receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name