AGC_AKT2 (RAC-beta serine/threonine-protein kinase)

Total number of chains: 24
Active chains: 17
Uniprot: AKT2_HUMAN
Kinase Domain Residues: 152 - 409
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 70.8% AF-P31751-K1A
DFGout None 5 20.8% 1GZKA
DFGout BBAminus 2 8.3% 8Q61A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
1O6KA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 479 0 TPO309 S474D RAC-beta serine/threonine-protein kinase
1O6LA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
AF-P31751-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 417 0 None None RAC-beta serine/threonine-protein kinase
AF-P31751-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 417 0 None None RAC-beta serine/threonine-protein kinase
3E87A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G95 Type1 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase
3E87B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G95 Type1 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase
2JDOA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I5S Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
2JDRA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
2UW9A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GVP Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
2X39A 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X39 Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
2XH5A 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X37 Type1 146 - 479 0 TPO309 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W RAC-beta serine/threonine-protein kinase
3D0EA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G93 Type1.5_Back 146 - 480 0 TPO309,TPO451 None RAC-beta serine/threonine-protein kinase
3D0EB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G93 Type1.5_Back 146 - 480 0 TPO309,TPO451 None RAC-beta serine/threonine-protein kinase
3E88A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G96 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase
3E88B 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G96 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase
3E8DA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G98 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase
3E8DB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G98 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase
9C1WA 2.0 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 440 0 None P115A,G116A RAC-beta serine/threonine-protein kinase
8Q61A 2.32 Inactive DFGout‑BBAminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn K06 Type3 1 - 435 0 None N2D RAC-beta serine/threonine-protein kinase
1GZKA 2.3 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 441 0 None None RAC-beta serine/threonine-protein kinase
1GZOA 2.75 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase
1GZNA 2.5 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase
1MRVA 2.8 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 147 - 440 0 None None RAC-beta serine/threonine-protein kinase
1MRYA 2.8 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aaioo APEdist_nnio No_ligand No_ligand 146 - 440 0 None None RAC-beta serine/threonine-protein kinase

AGC_AKT2 (RAC-beta serine/threonine-protein kinase)

Total number of chains: 24
Active chains: 17
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 70.8% AF-P31751-K1A
DFGout None 5 20.8% 1GZKA
DFGout BBAminus 2 8.3% 8Q61A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AKT2_HUMAN 1O6KA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 479 0 TPO309 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 1O6LA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN AF-P31751-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 417 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN AF-P31751-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 417 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3E87A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G95 Type1 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3E87B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G95 Type1 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 2JDOA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii I5S Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 2JDRA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 2UW9A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii GVP Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 2X39A 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X39 Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 2XH5A 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X37 Type1 146 - 479 0 TPO309 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3D0EA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G93 Type1.5_Back 146 - 480 0 TPO309,TPO451 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3D0EB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G93 Type1.5_Back 146 - 480 0 TPO309,TPO451 None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3E88A 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G96 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3E88B 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G96 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3E8DA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G98 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 3E8DB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii G98 Type1.5_Back 146 - 480 0 TPO309,TPO451 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 9C1WA 2.0 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 440 0 None P115A,G116A RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 8Q61A 2.32 Inactive DFGout‑BBAminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn K06 Type3 1 - 435 0 None N2D RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 1GZKA 2.3 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 441 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 1GZOA 2.75 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 1GZNA 2.5 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 1MRVA 2.8 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 147 - 440 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AKT2_HUMAN 1MRYA 2.8 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aaioo APEdist_nnio No_ligand No_ligand 146 - 440 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens

AGC_AKT2 (RAC-beta serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism