AGC_AKT2 (RAC-beta serine/threonine-protein kinase)

Total number of chains: 24
Active chains: 17
Uniprot: AKT2_HUMAN
Kinase Domain Residues: 152 - 409
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 70.8% AF-P31751-K1A
DFGout None 5 20.8% 1GZKA
DFGout BBAminus 2 8.3% 8Q61A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AKT2 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.7344 BLAminus -120.8, -176.05 56.87, 82.9 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.7488 Saltbr-in 2.7955 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.0271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.1933 APE11-dist-in 11.7594 APE10-dist-in 6.1185 APE9-dist-in 3.9212 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336.0 318.0 0 28 28 0 [[152, 409]] 1.0 1o6k AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.2578 12.9248 BLAminus -121.53, -178.18 58.41, 83.34 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.7937 Saltbr-in 2.7601 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.0061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.1734 APE11-dist-in 11.7399 APE10-dist-in 6.1223 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337.0 312.0 0 28 28 0 [[152, 409]] 1.0 1o6l AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AF-P31751-K1A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 6.2326 13.0233 BLAminus -113.23, -144.19 8.44, 78.9 -80.27, 18.08 299.23, 85.15 -63.04, -27.98 in-in in 8.7595 Saltbr-in 2.6382 HRD-in -78.66, -46.08 65.41, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.8612 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 154.65 APE9-dihe-na 130.96, 174.62 APE8-dihe-in -79.56, 129.32 APE8-rot-in 301.13 APE67-dihe-in -71.15, -16.28 -47.49, -43.65 APE12-dist-in 8.4056 APE11-dist-in 11.6766 APE10-dist-in 5.9196 APE9-dist-in 3.6888 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[152, 409]] 1.0 AF-P31751-K1 AGC_AKT2_HUMAN AGC 8.4e-100 339.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AF-P31751-K3A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 5.9258 12.9367 BLAminus -120.75, -176.12 46.87, 67.81 -72.56, 16.67 304.47, 92.86 -64.84, -25.38 in-in in 8.9082 Saltbr-in 2.6723 HRD-in -85.04, -45.39 68.23, 12.02 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.84, 152.71 APE9-dihe-na 130.61, 173.68 APE8-dihe-in -78.91, 130.99 APE8-rot-in 284.27 APE67-dihe-in -69.37, -17.14 -47.07, -44.67 APE12-dist-in 8.5425 APE11-dist-in 11.658 APE10-dist-in 5.9786 APE9-dist-in 3.7404 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[152, 409]] 1.0 AF-P31751-K3 AGC_AKT2_HUMAN AGC 8.4e-100 339.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3E87A P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.3556 13.3413 BLAminus -126.04, 163.87 68.85, 90.68 -105.7, 33.53 302.5, 89.72 -71.05, -31.02 in-in in 9.1955 Saltbr-in 2.6726 HRD-in -74.63, -46.2 65.87, 9.52 in-in-in SNCiii in-in ActLoopNT-in 2.9656 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 164.29 APE9-dihe-na 138.82, -139.79 APE8-dihe-in -129.72, 130.9 APE8-rot-in 295.88 APE67-dihe-in -69.5, -20.74 -43.13, -48.06 APE12-dist-in 8.2584 APE11-dist-in 11.703 APE10-dist-in 6.1143 APE9-dist-in 3.6694 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 A 335.0 323.0 0 28 28 0 [[152, 409]] 1.0 3e87 AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3E87B P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.3633 13.3278 BLAminus -125.6, 164.26 67.65, 91.39 -106.11, 33.4 302.92, 90.11 -70.63, -30.74 in-in in 9.2067 Saltbr-in 2.6574 HRD-in -73.89, -47.28 67.09, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 163.8 APE9-dihe-na 138.15, -140.19 APE8-dihe-in -128.95, 131.51 APE8-rot-in 293.83 APE67-dihe-in -69.92, -20.28 -43.71, -47.61 APE12-dist-in 8.2657 APE11-dist-in 11.7056 APE10-dist-in 6.1146 APE9-dist-in 3.6639 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 B 335.0 323.0 0 28 28 0 [[152, 409]] 1.0 3e87 AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 2JDOA P31751 146 477 481.0 I5S:61480 Type1 Active DFGin 6.4908 13.275 BLAminus -127.4, 177.55 60.46, 72.21 -91.22, 6.75 299.11, 106.21 -60.04, -25.16 in-in in 8.8329 Saltbr-in 2.5067 HRD-in -79.9, -47.34 72.69, -4.25 in-in-in SNCiii in-in ActLoopNT-in 2.9169 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.18, 166.21 APE9-dihe-na 136.64, -140.86 APE8-dihe-in -130.22, 129.82 APE8-rot-in 295.69 APE67-dihe-in -66.14, -22.16 -45.88, -48.65 APE12-dist-in 8.1361 APE11-dist-in 11.5699 APE10-dist-in 6.0298 APE9-dist-in 3.7712 None TPO309 TPO309 XRAY 1.8 0.177 0.21 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2jdo AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 2JDRA P31751 146 477 481.0 L20:61480 Type1 Active DFGin 6.2893 13.1867 BLAminus -140.76, 154.56 67.85, 87.58 -95.95, 16.78 295.18, 71.62 -47.79, -46.7 in-in in 8.7125 Saltbr-in 2.7965 HRD-in -80.08, -42.59 66.93, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.8739 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 174.01 APE9-dihe-na 115.68, -166.42 APE8-dihe-in -112.23, 130.56 APE8-rot-in 296.59 APE67-dihe-in -62.74, -25.12 -49.6, -46.59 APE12-dist-in 7.9416 APE11-dist-in 11.5698 APE10-dist-in 6.0234 APE9-dist-in 3.7731 None TPO309 TPO309 XRAY 2.3 0.196 0.252 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2jdr AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 2UW9A P31751 146 477 481.0 GVP:61480 Type1 Active DFGin 6.6921 13.4876 BLAminus -123.19, 167.76 65.45, 89.41 -103.32, 13.56 294.7, 84.5 -64.67, -30.65 in-in in 8.9152 Saltbr-in 3.4846 HRD-in -78.9, -54.33 80.74, -7.46 in-in-in SNCiii in-in ActLoopNT-in 2.8896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.24, 166.16 APE9-dihe-na 136.4, -140.08 APE8-dihe-in -134.83, 122.5 APE8-rot-in 314.64 APE67-dihe-in -71.56, -23.74 -40.7, -46.8 APE12-dist-in 8.1712 APE11-dist-in 11.4277 APE10-dist-in 5.9073 APE9-dist-in 3.8771 None TPO309 TPO309 XRAY 2.1 0.226 0.305 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2uw9 AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 2X39A P31751 146 477 481.0 X39:61480 Type1 Active DFGin 6.6088 13.1631 BLAminus -126.64, 166.41 70.83, 82.9 -98.53, 13.96 297.41, 90.75 -64.85, -22.35 in-in in 8.5371 Saltbr-in 2.7673 HRD-in -80.41, -44.67 68.55, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.9425 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.85, 165.7 APE9-dihe-na 131.55, -143.54 APE8-dihe-in -129.03, 132.57 APE8-rot-in 295.12 APE67-dihe-in -72.21, -20.28 -47.28, -46.05 APE12-dist-in 8.1761 APE11-dist-in 11.5188 APE10-dist-in 5.988 APE9-dist-in 3.8076 None TPO309 TPO309 XRAY 1.93 0.169 0.226 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2x39 AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 2XH5A P31751 146 479 481.0 X37:1480 Type1 Active DFGin 6.5052 13.5514 BLAminus -110.05, 164.58 66.53, 108.72 -126.32, 14.52 299.02, 81.83 -57.37, -39.56 in-in in 8.942 Saltbr-in 2.9072 HRD-in -77.83, -38.9 65.4, 4.31 in-in-in SNCiii in-in ActLoopNT-in 3.019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 176.38 APE9-dihe-na 101.87, -144.62 APE8-dihe-in -126.41, 124.09 APE8-rot-in 301.05 APE67-dihe-in -65.29, -29.42 -46.82, -46.71 APE12-dist-in 8.2873 APE11-dist-in 11.609 APE10-dist-in 6.03 APE9-dist-in 3.7961 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W TPO309 TPO309 XRAY 2.72 0.216 0.305 A 342.0 317.0 0 28 28 0 [[152, 409]] 1.0 2xh5 AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3D0EA P31751 146 480 481.0 G93:1 Type1.5_Back Active DFGin 6.7011 13.5456 BLAminus -125.73, 168.9 61.89, 84.21 -95.51, 25.74 292.33, 79.73 -76.94, 1.71 in-in in 9.0614 Saltbr-in 2.7639 HRD-in -80.14, -42.28 68.95, -5.28 in-in-in SNCiii in-in ActLoopNT-in 2.9325 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.97, 167.33 APE9-dihe-na 127.67, -168.31 APE8-dihe-in -106.36, 125.11 APE8-rot-in 301.0 APE67-dihe-in -64.27, -20.07 -41.91, -50.48 APE12-dist-in 8.2479 APE11-dist-in 11.6606 APE10-dist-in 6.0499 APE9-dist-in 4.016 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 A 335.0 324.0 0 28 28 0 [[152, 409]] 1.0 3d0e AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3D0EB P31751 146 480 481.0 G93:2 Type1.5_Back Active DFGin 6.8093 13.5647 BLAminus -120.57, 168.95 62.61, 83.67 -96.74, 28.63 294.15, 77.27 -76.08, -2.14 in-in in 9.1302 Saltbr-in 2.9929 HRD-in -78.43, -43.98 69.1, -0.1 in-in-in SNCiii in-in ActLoopNT-in 2.8678 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.44, 163.97 APE9-dihe-na 132.51, -165.35 APE8-dihe-in -107.37, 125.67 APE8-rot-in 301.69 APE67-dihe-in -66.88, -18.51 -42.11, -48.84 APE12-dist-in 8.2368 APE11-dist-in 11.6801 APE10-dist-in 6.0404 APE9-dist-in 3.8595 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 B 335.0 324.0 0 28 28 0 [[152, 409]] 1.0 3d0e AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3E88A P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.5769 13.4047 BLAminus -128.82, 173.63 61.99, 93.97 -108.84, 31.73 297.8, 80.14 -73.82, -16.27 in-in in 9.196 Saltbr-in 2.832 HRD-in -75.09, -42.0 67.98, -2.73 in-in-in SNCiii in-in ActLoopNT-in 3.0422 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.37, 168.63 APE9-dihe-na 135.96, -142.36 APE8-dihe-in -130.12, 129.82 APE8-rot-in 291.65 APE67-dihe-in -63.55, -20.99 -45.06, -54.18 APE12-dist-in 8.0726 APE11-dist-in 11.6337 APE10-dist-in 6.0031 APE9-dist-in 3.8446 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 A 335.0 321.0 0 28 28 0 [[152, 409]] 1.0 3e88 AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3E88B P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.5089 13.3271 BLAminus -128.8, 173.14 62.13, 94.09 -108.62, 31.59 298.9, 80.14 -73.92, -15.88 in-in in 9.2077 Saltbr-in 2.7239 HRD-in -75.96, -42.03 68.35, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.0376 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.45, 168.65 APE9-dihe-na 136.37, -142.41 APE8-dihe-in -130.19, 130.02 APE8-rot-in 291.1 APE67-dihe-in -63.44, -20.2 -45.4, -53.85 APE12-dist-in 8.063 APE11-dist-in 11.6261 APE10-dist-in 6.0043 APE9-dist-in 3.8531 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 B 335.0 321.0 0 28 28 0 [[152, 409]] 1.0 3e88 AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3E8DA P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.6266 13.6021 BLAminus -131.95, 161.19 63.93, 96.17 -108.94, 28.77 296.25, 77.68 -84.56, 5.75 in-in in 9.2004 Saltbr-in 2.8047 HRD-in -77.32, -43.78 69.76, 5.0 in-in-in SNCiii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.79, 164.59 APE9-dihe-na 136.0, -148.3 APE8-dihe-in -124.36, 129.64 APE8-rot-in 293.72 APE67-dihe-in -64.33, -19.25 -43.26, -53.33 APE12-dist-in 8.0866 APE11-dist-in 11.6652 APE10-dist-in 5.9945 APE9-dist-in 3.6895 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 A 335.0 316.0 0 28 28 0 [[152, 409]] 1.0 3e8d AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 3E8DB P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.5882 13.5569 BLAminus -130.8, 161.71 64.68, 95.04 -108.93, 28.35 296.53, 82.54 -84.83, 6.03 in-in in 9.2388 Saltbr-in 2.8509 HRD-in -77.39, -43.59 70.5, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.0793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.5, 165.61 APE9-dihe-na 135.83, -147.81 APE8-dihe-in -124.63, 129.91 APE8-rot-in 295.04 APE67-dihe-in -64.9, -18.78 -43.89, -52.5 APE12-dist-in 8.0825 APE11-dist-in 11.6493 APE10-dist-in 5.988 APE9-dist-in 3.7067 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 B 335.0 318.0 0 28 28 0 [[152, 409]] 1.0 3e8d AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 9C1WA P31751 3 440 481.0 XOO:501 Allosteric Inactive DFGout 19.216 8.694 BBAminus -83.52, 155.45 -120.63, 49.83 -105.5, 7.82 304.69, 159.06 -62.82, 151.74 out-out out 13.6619 Saltbr-out 13.2123 HRD-in -78.89, -48.84 68.68, 2.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -152.67 APE8-dihe-in -117.72, 106.37 APE8-rot-out 64.01 APE67-dihe-in -60.58, -16.49 -68.37, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.7256 P115A,G116A None None XRAY 2.0 0.207 0.242 A 446.0 388.0 19 28 14 14 [[152, 409]] 1.0 9c1w AGC_AKT2_HUMAN AGC 4.1e-99 336.9 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 8Q61A P31751 1 435 481.0 K06:60501 Type3 Inactive DFGout 18.8901 8.0157 BBAminus -86.01, 164.11 -136.51, 53.07 -106.57, 16.06 303.39, 155.45 -59.47, 122.51 out-out out 16.6635 Saltbr-out 14.734 HRD-in -73.93, -39.6 78.27, -25.65 out-out-none SNCoon out-none ActLoopNT-out 15.0433 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.87, 132.41 999.0, 120.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N2D None None XRAY 2.32 0.212 0.263 A 483.0 382.0 13 28 22 6 [[152, 409]] 1.0 8q61 AGC_AKT2_HUMAN AGC 5.1e-99 336.6 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 1GZKA P31751 146 441 481.0 No_ligand No_ligand Inactive DFGout 12.8786 7.508 None -88.28, 169.77 -121.29, 63.03 159.26, 151.54 56.46, 80.21 -112.21, 146.16 in-none in 8.9716 Saltbr-none 999.0 HRD-in -76.88, -35.25 63.45, -21.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.79 APE8-rot-out 55.76 APE67-dihe-out -75.52, 140.15 -78.96, 137.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.248 0.319 A 315.0 271.0 25 28 12 16 [[152, 409]] 1.0 1gzk AGC_AKT2_HUMAN AGC 1.4e-99 338.4 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 1GZOA P31751 146 442 481.0 No_ligand No_ligand Inactive DFGout 13.457 7.5507 None -89.05, 165.48 -112.0, 63.41 173.4, 174.77 48.32, 79.0 -110.82, 136.89 in-none in 8.9819 Saltbr-none 999.0 HRD-in -58.12, -43.89 72.65, -26.96 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.94 APE8-rot-out 52.4 APE67-dihe-out -68.85, 138.24 -64.09, 126.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.248 0.31 A 315.0 272.0 25 28 12 16 [[152, 409]] 1.0 1gzo AGC_AKT2_HUMAN AGC 1.4e-99 338.4 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 1GZNA P31751 146 442 481.0 No_ligand No_ligand Inactive DFGout 13.061 7.2072 None -86.08, 145.09 -87.68, 45.88 -175.89, 163.19 41.36, 87.18 -86.05, 112.83 in-none in 8.4667 Saltbr-none 999.0 HRD-in -65.46, -39.14 69.44, -32.45 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.06 APE8-rot-out 45.36 APE67-dihe-out -66.55, 140.26 -68.72, 127.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.268 0.319 A 335.0 272.0 25 28 12 16 [[152, 409]] 1.0 1gzn AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 1MRVA P31751 147 440 481.0 No_ligand No_ligand Inactive DFGout 12.5983 7.9074 None -100.04, 151.93 -107.39, 54.86 -100.48, 999.0 298.45, 163.68 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -61.99, -43.37 76.14, -22.13 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.0, 124.68 999.0, 121.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.247 0.295 A 339.0 261.0 33 28 9 19 [[152, 409]] 1.0 1mrv AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 1MRYA P31751 146 440 481.0 No_ligand No_ligand Inactive DFGout 12.7563 7.9894 None -121.34, 168.73 -126.98, 50.44 -103.46, -121.56 310.73, 158.04 172.34, 79.61 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.55, -34.24 66.17, -25.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnio APE10-dihe-na 999.0, 178.93 APE9-dihe-na -93.7, 48.0 APE8-dihe-in -94.52, 126.11 APE8-rot-out 162.32 APE67-dihe-out -83.28, 134.12 -46.1, 120.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.4839 APE9-dist-out 16.4904 None None None XRAY 2.8 0.227 0.272 A 339.0 270.0 25 28 15 13 [[152, 409]] 1.0 1mry AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase

AGC_AKT2 (RAC-beta serine/threonine-protein kinase)

Total number of chains: 24
Active chains: 17
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 70.8% AF-P31751-K1A
DFGout None 5 20.8% 1GZKA
DFGout BBAminus 2 8.3% 8Q61A

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.7344 BLAminus -120.8, -176.05 56.87, 82.9 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.7488 Saltbr-in 2.7955 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.0271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.1933 APE11-dist-in 11.7594 APE10-dist-in 6.1185 APE9-dist-in 3.9212 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336.0 318.0 0 28 28 0 [[152, 409]] 1.0 1o6k Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.2578 12.9248 BLAminus -121.53, -178.18 58.41, 83.34 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.7937 Saltbr-in 2.7601 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.0061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.1734 APE11-dist-in 11.7399 APE10-dist-in 6.1223 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337.0 312.0 0 28 28 0 [[152, 409]] 1.0 1o6l Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN AF-P31751-K1A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 6.2326 13.0233 BLAminus -113.23, -144.19 8.44, 78.9 -80.27, 18.08 299.23, 85.15 -63.04, -27.98 in-in in 8.7595 Saltbr-in 2.6382 HRD-in -78.66, -46.08 65.41, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.8612 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 154.65 APE9-dihe-na 130.96, 174.62 APE8-dihe-in -79.56, 129.32 APE8-rot-in 301.13 APE67-dihe-in -71.15, -16.28 -47.49, -43.65 APE12-dist-in 8.4056 APE11-dist-in 11.6766 APE10-dist-in 5.9196 APE9-dist-in 3.6888 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[152, 409]] 1.0 AF-P31751-K1 Homo sapiens AGC_AKT2_HUMAN AGC 8.4e-100 339.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN AF-P31751-K3A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 5.9258 12.9367 BLAminus -120.75, -176.12 46.87, 67.81 -72.56, 16.67 304.47, 92.86 -64.84, -25.38 in-in in 8.9082 Saltbr-in 2.6723 HRD-in -85.04, -45.39 68.23, 12.02 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.84, 152.71 APE9-dihe-na 130.61, 173.68 APE8-dihe-in -78.91, 130.99 APE8-rot-in 284.27 APE67-dihe-in -69.37, -17.14 -47.07, -44.67 APE12-dist-in 8.5425 APE11-dist-in 11.658 APE10-dist-in 5.9786 APE9-dist-in 3.7404 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[152, 409]] 1.0 AF-P31751-K3 Homo sapiens AGC_AKT2_HUMAN AGC 8.4e-100 339.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3E87A P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.3556 13.3413 BLAminus -126.04, 163.87 68.85, 90.68 -105.7, 33.53 302.5, 89.72 -71.05, -31.02 in-in in 9.1955 Saltbr-in 2.6726 HRD-in -74.63, -46.2 65.87, 9.52 in-in-in SNCiii in-in ActLoopNT-in 2.9656 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 164.29 APE9-dihe-na 138.82, -139.79 APE8-dihe-in -129.72, 130.9 APE8-rot-in 295.88 APE67-dihe-in -69.5, -20.74 -43.13, -48.06 APE12-dist-in 8.2584 APE11-dist-in 11.703 APE10-dist-in 6.1143 APE9-dist-in 3.6694 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 A 335.0 323.0 0 28 28 0 [[152, 409]] 1.0 3e87 Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3E87B P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.3633 13.3278 BLAminus -125.6, 164.26 67.65, 91.39 -106.11, 33.4 302.92, 90.11 -70.63, -30.74 in-in in 9.2067 Saltbr-in 2.6574 HRD-in -73.89, -47.28 67.09, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 163.8 APE9-dihe-na 138.15, -140.19 APE8-dihe-in -128.95, 131.51 APE8-rot-in 293.83 APE67-dihe-in -69.92, -20.28 -43.71, -47.61 APE12-dist-in 8.2657 APE11-dist-in 11.7056 APE10-dist-in 6.1146 APE9-dist-in 3.6639 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 B 335.0 323.0 0 28 28 0 [[152, 409]] 1.0 3e87 Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 2JDOA P31751 146 477 481.0 I5S:61480 Type1 Active DFGin 6.4908 13.275 BLAminus -127.4, 177.55 60.46, 72.21 -91.22, 6.75 299.11, 106.21 -60.04, -25.16 in-in in 8.8329 Saltbr-in 2.5067 HRD-in -79.9, -47.34 72.69, -4.25 in-in-in SNCiii in-in ActLoopNT-in 2.9169 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.18, 166.21 APE9-dihe-na 136.64, -140.86 APE8-dihe-in -130.22, 129.82 APE8-rot-in 295.69 APE67-dihe-in -66.14, -22.16 -45.88, -48.65 APE12-dist-in 8.1361 APE11-dist-in 11.5699 APE10-dist-in 6.0298 APE9-dist-in 3.7712 None TPO309 TPO309 XRAY 1.8 0.177 0.21 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2jdo Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 2JDRA P31751 146 477 481.0 L20:61480 Type1 Active DFGin 6.2893 13.1867 BLAminus -140.76, 154.56 67.85, 87.58 -95.95, 16.78 295.18, 71.62 -47.79, -46.7 in-in in 8.7125 Saltbr-in 2.7965 HRD-in -80.08, -42.59 66.93, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.8739 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 174.01 APE9-dihe-na 115.68, -166.42 APE8-dihe-in -112.23, 130.56 APE8-rot-in 296.59 APE67-dihe-in -62.74, -25.12 -49.6, -46.59 APE12-dist-in 7.9416 APE11-dist-in 11.5698 APE10-dist-in 6.0234 APE9-dist-in 3.7731 None TPO309 TPO309 XRAY 2.3 0.196 0.252 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2jdr Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 2UW9A P31751 146 477 481.0 GVP:61480 Type1 Active DFGin 6.6921 13.4876 BLAminus -123.19, 167.76 65.45, 89.41 -103.32, 13.56 294.7, 84.5 -64.67, -30.65 in-in in 8.9152 Saltbr-in 3.4846 HRD-in -78.9, -54.33 80.74, -7.46 in-in-in SNCiii in-in ActLoopNT-in 2.8896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.24, 166.16 APE9-dihe-na 136.4, -140.08 APE8-dihe-in -134.83, 122.5 APE8-rot-in 314.64 APE67-dihe-in -71.56, -23.74 -40.7, -46.8 APE12-dist-in 8.1712 APE11-dist-in 11.4277 APE10-dist-in 5.9073 APE9-dist-in 3.8771 None TPO309 TPO309 XRAY 2.1 0.226 0.305 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2uw9 Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 2X39A P31751 146 477 481.0 X39:61480 Type1 Active DFGin 6.6088 13.1631 BLAminus -126.64, 166.41 70.83, 82.9 -98.53, 13.96 297.41, 90.75 -64.85, -22.35 in-in in 8.5371 Saltbr-in 2.7673 HRD-in -80.41, -44.67 68.55, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.9425 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.85, 165.7 APE9-dihe-na 131.55, -143.54 APE8-dihe-in -129.03, 132.57 APE8-rot-in 295.12 APE67-dihe-in -72.21, -20.28 -47.28, -46.05 APE12-dist-in 8.1761 APE11-dist-in 11.5188 APE10-dist-in 5.988 APE9-dist-in 3.8076 None TPO309 TPO309 XRAY 1.93 0.169 0.226 A 342.0 312.0 0 28 28 0 [[152, 409]] 1.0 2x39 Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 2XH5A P31751 146 479 481.0 X37:1480 Type1 Active DFGin 6.5052 13.5514 BLAminus -110.05, 164.58 66.53, 108.72 -126.32, 14.52 299.02, 81.83 -57.37, -39.56 in-in in 8.942 Saltbr-in 2.9072 HRD-in -77.83, -38.9 65.4, 4.31 in-in-in SNCiii in-in ActLoopNT-in 3.019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 176.38 APE9-dihe-na 101.87, -144.62 APE8-dihe-in -126.41, 124.09 APE8-rot-in 301.05 APE67-dihe-in -65.29, -29.42 -46.82, -46.71 APE12-dist-in 8.2873 APE11-dist-in 11.609 APE10-dist-in 6.03 APE9-dist-in 3.7961 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W TPO309 TPO309 XRAY 2.72 0.216 0.305 A 342.0 317.0 0 28 28 0 [[152, 409]] 1.0 2xh5 Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3D0EA P31751 146 480 481.0 G93:1 Type1.5_Back Active DFGin 6.7011 13.5456 BLAminus -125.73, 168.9 61.89, 84.21 -95.51, 25.74 292.33, 79.73 -76.94, 1.71 in-in in 9.0614 Saltbr-in 2.7639 HRD-in -80.14, -42.28 68.95, -5.28 in-in-in SNCiii in-in ActLoopNT-in 2.9325 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.97, 167.33 APE9-dihe-na 127.67, -168.31 APE8-dihe-in -106.36, 125.11 APE8-rot-in 301.0 APE67-dihe-in -64.27, -20.07 -41.91, -50.48 APE12-dist-in 8.2479 APE11-dist-in 11.6606 APE10-dist-in 6.0499 APE9-dist-in 4.016 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 A 335.0 324.0 0 28 28 0 [[152, 409]] 1.0 3d0e Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3D0EB P31751 146 480 481.0 G93:2 Type1.5_Back Active DFGin 6.8093 13.5647 BLAminus -120.57, 168.95 62.61, 83.67 -96.74, 28.63 294.15, 77.27 -76.08, -2.14 in-in in 9.1302 Saltbr-in 2.9929 HRD-in -78.43, -43.98 69.1, -0.1 in-in-in SNCiii in-in ActLoopNT-in 2.8678 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.44, 163.97 APE9-dihe-na 132.51, -165.35 APE8-dihe-in -107.37, 125.67 APE8-rot-in 301.69 APE67-dihe-in -66.88, -18.51 -42.11, -48.84 APE12-dist-in 8.2368 APE11-dist-in 11.6801 APE10-dist-in 6.0404 APE9-dist-in 3.8595 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 B 335.0 324.0 0 28 28 0 [[152, 409]] 1.0 3d0e Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3E88A P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.5769 13.4047 BLAminus -128.82, 173.63 61.99, 93.97 -108.84, 31.73 297.8, 80.14 -73.82, -16.27 in-in in 9.196 Saltbr-in 2.832 HRD-in -75.09, -42.0 67.98, -2.73 in-in-in SNCiii in-in ActLoopNT-in 3.0422 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.37, 168.63 APE9-dihe-na 135.96, -142.36 APE8-dihe-in -130.12, 129.82 APE8-rot-in 291.65 APE67-dihe-in -63.55, -20.99 -45.06, -54.18 APE12-dist-in 8.0726 APE11-dist-in 11.6337 APE10-dist-in 6.0031 APE9-dist-in 3.8446 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 A 335.0 321.0 0 28 28 0 [[152, 409]] 1.0 3e88 Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3E88B P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.5089 13.3271 BLAminus -128.8, 173.14 62.13, 94.09 -108.62, 31.59 298.9, 80.14 -73.92, -15.88 in-in in 9.2077 Saltbr-in 2.7239 HRD-in -75.96, -42.03 68.35, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.0376 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.45, 168.65 APE9-dihe-na 136.37, -142.41 APE8-dihe-in -130.19, 130.02 APE8-rot-in 291.1 APE67-dihe-in -63.44, -20.2 -45.4, -53.85 APE12-dist-in 8.063 APE11-dist-in 11.6261 APE10-dist-in 6.0043 APE9-dist-in 3.8531 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 B 335.0 321.0 0 28 28 0 [[152, 409]] 1.0 3e88 Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3E8DA P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.6266 13.6021 BLAminus -131.95, 161.19 63.93, 96.17 -108.94, 28.77 296.25, 77.68 -84.56, 5.75 in-in in 9.2004 Saltbr-in 2.8047 HRD-in -77.32, -43.78 69.76, 5.0 in-in-in SNCiii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.79, 164.59 APE9-dihe-na 136.0, -148.3 APE8-dihe-in -124.36, 129.64 APE8-rot-in 293.72 APE67-dihe-in -64.33, -19.25 -43.26, -53.33 APE12-dist-in 8.0866 APE11-dist-in 11.6652 APE10-dist-in 5.9945 APE9-dist-in 3.6895 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 A 335.0 316.0 0 28 28 0 [[152, 409]] 1.0 3e8d Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 3E8DB P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.5882 13.5569 BLAminus -130.8, 161.71 64.68, 95.04 -108.93, 28.35 296.53, 82.54 -84.83, 6.03 in-in in 9.2388 Saltbr-in 2.8509 HRD-in -77.39, -43.59 70.5, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.0793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.5, 165.61 APE9-dihe-na 135.83, -147.81 APE8-dihe-in -124.63, 129.91 APE8-rot-in 295.04 APE67-dihe-in -64.9, -18.78 -43.89, -52.5 APE12-dist-in 8.0825 APE11-dist-in 11.6493 APE10-dist-in 5.988 APE9-dist-in 3.7067 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 B 335.0 318.0 0 28 28 0 [[152, 409]] 1.0 3e8d Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 9C1WA P31751 3 440 481.0 XOO:501 Allosteric Inactive DFGout 19.216 8.694 BBAminus -83.52, 155.45 -120.63, 49.83 -105.5, 7.82 304.69, 159.06 -62.82, 151.74 out-out out 13.6619 Saltbr-out 13.2123 HRD-in -78.89, -48.84 68.68, 2.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -152.67 APE8-dihe-in -117.72, 106.37 APE8-rot-out 64.01 APE67-dihe-in -60.58, -16.49 -68.37, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.7256 P115A,G116A None None XRAY 2.0 0.207 0.242 A 446.0 388.0 19 28 14 14 [[152, 409]] 1.0 9c1w Homo sapiens AGC_AKT2_HUMAN AGC 4.1e-99 336.9 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 8Q61A P31751 1 435 481.0 K06:60501 Type3 Inactive DFGout 18.8901 8.0157 BBAminus -86.01, 164.11 -136.51, 53.07 -106.57, 16.06 303.39, 155.45 -59.47, 122.51 out-out out 16.6635 Saltbr-out 14.734 HRD-in -73.93, -39.6 78.27, -25.65 out-out-none SNCoon out-none ActLoopNT-out 15.0433 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.87, 132.41 999.0, 120.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N2D None None XRAY 2.32 0.212 0.263 A 483.0 382.0 13 28 22 6 [[152, 409]] 1.0 8q61 Homo sapiens AGC_AKT2_HUMAN AGC 5.1e-99 336.6 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 1GZKA P31751 146 441 481.0 No_ligand No_ligand Inactive DFGout 12.8786 7.508 None -88.28, 169.77 -121.29, 63.03 159.26, 151.54 56.46, 80.21 -112.21, 146.16 in-none in 8.9716 Saltbr-none 999.0 HRD-in -76.88, -35.25 63.45, -21.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.79 APE8-rot-out 55.76 APE67-dihe-out -75.52, 140.15 -78.96, 137.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.248 0.319 A 315.0 271.0 25 28 12 16 [[152, 409]] 1.0 1gzk Homo sapiens AGC_AKT2_HUMAN AGC 1.4e-99 338.4 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 1GZOA P31751 146 442 481.0 No_ligand No_ligand Inactive DFGout 13.457 7.5507 None -89.05, 165.48 -112.0, 63.41 173.4, 174.77 48.32, 79.0 -110.82, 136.89 in-none in 8.9819 Saltbr-none 999.0 HRD-in -58.12, -43.89 72.65, -26.96 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.94 APE8-rot-out 52.4 APE67-dihe-out -68.85, 138.24 -64.09, 126.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.248 0.31 A 315.0 272.0 25 28 12 16 [[152, 409]] 1.0 1gzo Homo sapiens AGC_AKT2_HUMAN AGC 1.4e-99 338.4 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 1GZNA P31751 146 442 481.0 No_ligand No_ligand Inactive DFGout 13.061 7.2072 None -86.08, 145.09 -87.68, 45.88 -175.89, 163.19 41.36, 87.18 -86.05, 112.83 in-none in 8.4667 Saltbr-none 999.0 HRD-in -65.46, -39.14 69.44, -32.45 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.06 APE8-rot-out 45.36 APE67-dihe-out -66.55, 140.26 -68.72, 127.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.268 0.319 A 335.0 272.0 25 28 12 16 [[152, 409]] 1.0 1gzn Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 1MRVA P31751 147 440 481.0 No_ligand No_ligand Inactive DFGout 12.5983 7.9074 None -100.04, 151.93 -107.39, 54.86 -100.48, 999.0 298.45, 163.68 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -61.99, -43.37 76.14, -22.13 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.0, 124.68 999.0, 121.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.247 0.295 A 339.0 261.0 33 28 9 19 [[152, 409]] 1.0 1mrv Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AKT2 AKT2_HUMAN 1MRYA P31751 146 440 481.0 No_ligand No_ligand Inactive DFGout 12.7563 7.9894 None -121.34, 168.73 -126.98, 50.44 -103.46, -121.56 310.73, 158.04 172.34, 79.61 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.55, -34.24 66.17, -25.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnio APE10-dihe-na 999.0, 178.93 APE9-dihe-na -93.7, 48.0 APE8-dihe-in -94.52, 126.11 APE8-rot-out 162.32 APE67-dihe-out -83.28, 134.12 -46.1, 120.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.4839 APE9-dist-out 16.4904 None None None XRAY 2.8 0.227 0.272 A 339.0 270.0 25 28 15 13 [[152, 409]] 1.0 1mry Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.0 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase

AGC_AKT2 (RAC-beta serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name