Ligand: L20

Total number of chains: 3
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 2JDRA
DFGin BLBplus 1 33.3% 9IRLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC AKT2 AKT2_HUMAN 2JDRA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
CAMK PIM1 PIM1_HUMAN 5DGZA 2.502 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
TYR SRC SRC_HUMAN 9IRLA 2.031 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao A1L20 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src

Ligand: L20

Total number of chains: 6
Active chains: 5
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 83.3% 2JDSA
DFGin BLBplus 1 16.7% 9IRLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_BOVIN 2UZUE 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 16 - 351 0 None None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 2JDSA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 2JDVA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 16 - 351 0 TPO198,SEP339 V105T,V124A,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC AKT2 AKT2_HUMAN 2JDRA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
CAMK PIM1 PIM1_HUMAN 5DGZA 2.502 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
TYR SRC SRC_HUMAN 9IRLA 2.031 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao A1L20 Allosteric 86 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Ligand: L20

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2JDSA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_BOVIN 2UZUE 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 16 - 351 0 None None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 2JDSA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 2JDVA 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii L20 Type1 16 - 351 0 TPO198,SEP339 V105T,V124A,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus