LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)

Group: TKL
Uniprot: LRRK2_HUMAN
Domain boundary: 1875 - 2134


Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-Q5S007-K1A
DFGin BLBplus 4 6VP6A
DFGin None 1 8TZHA
DFGinter None 9 7LI4A
DFGout BBAminus 8 8U8AB
DFGout None 3 8FO9E
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q5S007-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1867 - 2142 None None 0
8TXZA 3.05 Active DFGin BLAminus in-in in-in A1N Type1 1334 - 2522 None None 0
8SMCC 4.02 Inactive DFGin BLAminus in-out in-in TVT Type1 1329 - 2527 None None 0
8U7HC 3.8 Active DFGin BLAminus in-in in-in A0T Type1 1329 - 2527 None None 0
8FO7C 3.52 Inactive DFGin BLAminus in-out in-in 4K4 Type1 1329 - 2527 None None 0
8TZGA 2.7 Inactive DFGin BLAminus in-out in-in A1N Type1 1333 - 2522 I2020T None 0
8FO9A 3.48 Active DFGin BLAminus in-in in-in ATP Type1 1329 - 2527 None None 0
8FO9C 3.48 Active DFGin BLAminus in-in in-in ATP Type1 1329 - 2527 None None 0
8TZCA 2.7 Active DFGin BLAminus in-in in-in A1N Type1 1333 - 2522 G2019S None 0
6VP8A 3.5 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
6VNOA 3.5 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
6VP6A 3.47 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
6VP7A 3.5 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
8TZHA 3.9 Inactive DFGin None in-out none-in A1N Type1 627 - 2522 None None 14
7LHTA 3.5 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
7LHTB 3.5 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
7LHWA 3.7 Inactive DFGinter None out-out out-in ATP Type1 540 - 2527 None None 3
7LI4A 3.1 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
8FO2E 4.13 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
8FO8C 3.88 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
8FO8E 3.88 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
8FO9F 3.48 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
7LI3A 3.8 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
8TZBA 3.1 Inactive DFGout BBAminus in-out none-none T3X Type2 1334 - 2522 None None 16
8U7LA 3.6 Inactive DFGout BBAminus in-out none-out T3X Type2 558 - 2526 None None 13
8U7LB 3.6 Inactive DFGout BBAminus in-out none-out T3X Type2 558 - 2526 None None 13
8U8AB 3.4 Inactive DFGout BBAminus in-out none-out 0LI Type2 558 - 2526 None None 13
8U8AC 3.4 Inactive DFGout BBAminus in-out none-out 0LI Type2 558 - 2526 None None 13
8U8BA 3.7 Inactive DFGout BBAminus in-out none-out 919 Type2 558 - 2527 None None 13
8U8BB 3.7 Inactive DFGout BBAminus in-out none-out 919 Type2 558 - 2527 None None 13
8TYQA 2.99 Inactive DFGout BBAminus in-out none-none T3X Type2 1335 - 2525 G2019S None 15
8FO9E 3.48 Inactive DFGout None out-out out-in ATP Type1 12 - 2527 None None 3
8TZEA 2.9 Inactive DFGout None in-in none-none T3X Type2 1624 - 2522 None None 15
8TZFA 3.4 Inactive DFGout None in-in none-none T3X Type2 587 - 2522 I2020T None 15

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)

Group: TKL
Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-Q5S007-K1A
DFGin BLBplus 4 6VP6A
DFGin None 1 8TZHA
DFGinter None 9 7LI4A
DFGout BBAminus 8 8U8AB
DFGout None 3 8FO9E
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens LRRK2_HUMAN AF-Q5S007-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1867 - 2142 None None 0
Homo sapiens LRRK2_HUMAN 8TXZA 3.05 Active DFGin BLAminus in-in in-in A1N Type1 1334 - 2522 None None 0
Homo sapiens LRRK2_HUMAN 8SMCC 4.02 Inactive DFGin BLAminus in-out in-in TVT Type1 1329 - 2527 None None 0
Homo sapiens Q17RV3_HUMAN 8U7HC 3.8 Active DFGin BLAminus in-in in-in A0T Type1 1329 - 2527 None None 0
Homo sapiens LRRK2_HUMAN 8FO7C 3.52 Inactive DFGin BLAminus in-out in-in 4K4 Type1 1329 - 2527 None None 0
Homo sapiens LRRK2_HUMAN 8TZGA 2.7 Inactive DFGin BLAminus in-out in-in A1N Type1 1333 - 2522 I2020T None 0
Homo sapiens LRRK2_HUMAN 8FO9A 3.48 Active DFGin BLAminus in-in in-in ATP Type1 1329 - 2527 None None 0
Homo sapiens LRRK2_HUMAN 8FO9C 3.48 Active DFGin BLAminus in-in in-in ATP Type1 1329 - 2527 None None 0
Homo sapiens LRRK2_HUMAN 8TZCA 2.7 Active DFGin BLAminus in-in in-in A1N Type1 1333 - 2522 G2019S None 0
Homo sapiens LRRK2_HUMAN 6VP8A 3.5 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
Homo sapiens LRRK2_HUMAN 6VNOA 3.5 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
Homo sapiens LRRK2_HUMAN 6VP6A 3.47 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
Homo sapiens LRRK2_HUMAN 6VP7A 3.5 Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 None X1343 16
Homo sapiens LRRK2_HUMAN 8TZHA 3.9 Inactive DFGin None in-out none-in A1N Type1 627 - 2522 None None 14
Homo sapiens LRRK2_HUMAN 7LHTA 3.5 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 7LHTB 3.5 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 7LHWA 3.7 Inactive DFGinter None out-out out-in ATP Type1 540 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 7LI4A 3.1 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 8FO2E 4.13 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 8FO8C 3.88 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 8FO8E 3.88 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 8FO9F 3.48 Inactive DFGinter None out-out out-in ATP Type1 12 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 7LI3A 3.8 Inactive DFGinter None out-out out-in ATP Type1 558 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 8TZBA 3.1 Inactive DFGout BBAminus in-out none-none T3X Type2 1334 - 2522 None None 16
Homo sapiens LRRK2_HUMAN 8U7LA 3.6 Inactive DFGout BBAminus in-out none-out T3X Type2 558 - 2526 None None 13
Homo sapiens LRRK2_HUMAN 8U7LB 3.6 Inactive DFGout BBAminus in-out none-out T3X Type2 558 - 2526 None None 13
Homo sapiens LRRK2_HUMAN 8U8AB 3.4 Inactive DFGout BBAminus in-out none-out 0LI Type2 558 - 2526 None None 13
Homo sapiens LRRK2_HUMAN 8U8AC 3.4 Inactive DFGout BBAminus in-out none-out 0LI Type2 558 - 2526 None None 13
Homo sapiens LRRK2_HUMAN 8U8BA 3.7 Inactive DFGout BBAminus in-out none-out 919 Type2 558 - 2527 None None 13
Homo sapiens LRRK2_HUMAN 8U8BB 3.7 Inactive DFGout BBAminus in-out none-out 919 Type2 558 - 2527 None None 13
Homo sapiens LRRK2_HUMAN 8TYQA 2.99 Inactive DFGout BBAminus in-out none-none T3X Type2 1335 - 2525 G2019S None 15
Homo sapiens LRRK2_HUMAN 8FO9E 3.48 Inactive DFGout None out-out out-in ATP Type1 12 - 2527 None None 3
Homo sapiens LRRK2_HUMAN 8TZEA 2.9 Inactive DFGout None in-in none-none T3X Type2 1624 - 2522 None None 15
Homo sapiens LRRK2_HUMAN 8TZFA 3.4 Inactive DFGout None in-in none-none T3X Type2 587 - 2522 I2020T None 15

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)

No non-human structures known.