8TZC

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)
Group: TKL
Uniprot: LRRK2_HUMAN
Organism: Homo sapiens
Domain boundary: 1875 - 2134
Resolu: 2.7

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in A1N Type1 1333 - 2522 0
Representative sequence - Chain A
1342 1352 1362 1372
NRMKLMIVGN TGSGKtTLLQ QLMktkksdl gmqsATVGID
1382 1392 1402 1412
VKDWPiqird krkrdlVLNV WDFAGREEFY STHPHFMTQR
1422 1432 1442 1452
ALYLAVYDls kgqaevdamk PWLFnikara sssPVILVGT
1462 1472 1482 1492
hldvsdekqr kacmskitke llnkrgfpaI RDYHFVnate
1502 1512 1522 1532
esdalaklRK TIINESLnfk irdqlvvgql ipdcyvelek
1542 1552 1562 1572
iilserknvp iefpvidrkr llqlvrenql qldenelphA
1582 1592 1602 1612
VHFLNESGVL LHFQDPALQL SDLYFVEPKW LCKIMAQILt
1622 1632 1642 1652
vkvegcpkhp KGIISRRDVE KFlskkrkfp knymsqYFKL
1662 1672 1682 1692
LEKFQIALPI geeyLLVPSS LSDHRPVIEL PHCENSEIII
1702 1712 1722 1732
RLYEMPYFPM GFWSRLINRL LEISPYMLSg rerALRPNRM
1742 1752 1762 1772
YWRQGIYLNW SPEAYCLVGS EVLdnhPESF LKITVPSCRK
1782 1792 1802 1812
GCILLGQVVD HIDSLMEEWF PGLLEidicg egeTLLKKWA
1822 1832 1842 1852
LYSFNDGEEH QKILLDDLMK KAEEGDLLVN pdqprLTIPI
1862 1872 1882 1892
SQIAPDLILA DLPRNIMLNN DELEFEQAPE FLLGDGSFGS
1902 1912 1922 1932
VYRAAYEGEE VAVKIFNKHT SLRLLRQELV VLCHLHHPSL
1942 1952 1962 1972
ISLLAAGIRP RMLVMELASK GSLDRLLQQD KASLTRTLQH
1982 1992 2002 2012
RIALHVADGL RYLHSAMIIY RDLKPHNVLL FTLYPNAAII
2022 2032 2042 2052
AKIADYSIAQ YCCRMGIKTS EGTPGFRAPE VARGNVIYNQ
2062 2072 2082 2092
QADVYSFGLL LYDILTTGGR IVeglkfpne FDELEIqGKL
2102 2112 2122 2132
PDPVKEYGCA PWPMVEKLIK QCLKENPQER PTSAQVFDIL
2142 2152 2162 2172
NSAELVCLTR RILLPKNVIV ECMVAthhns rnaSIWLGCg
2182 2192 2202 2212
htdrGQLSFL DLntEGYTSE EVAdsRILCL ALvhlpveke
2222 2232 2242 2252
swIVSGTQSG TLLVINtedg kkrhtlekmt dSVTCLYCns
2262 2272 2282 2292
fskqskqknf LLVGTADGKL AIFedktvkl kgaaPLKILN
2302 2312 2322 2332
IgnvsTPLMC LSEStnster nvMWGGCGTK IFSFsndfTI
2342 2352 2362 2372
QKLIETRTSQ LFSYAAFSDs NIITVVVDTA LYIAKQNSPV
2382 2392 2402 2412
VEVWDKkTEK LCGLIDCVHF Lrevmvkenk eskhkmsYSG
2422 2432 2442 2452
RVKTLCLQKN TALWIGTGGG HILLLDLSTR RLIRVIYNFC
2462 2472 2482 2492
NSVRVMMTAQ LgslKNVMLV LGYNRknteg tqkqkeIQSC
2502 2512 2522
LTVWDINLPH EVQNLEKHIE VRKELAEKMR rtsve
Lower-case residues are disordered in structure.
Mutations: G2019S
Phosphorylation: None