6VP8

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)
Group: TKL
Uniprot: LRRK2_HUMAN
Organism: Homo sapiens
Domain boundary: 1875 - 2134
Resolu: 3.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus in-out none-none No_ligand No_ligand 1330 - 2525 16
Representative sequence - Chain A
1339 1349 1359 1369
VPYNRMKLMI VGNTGSGKTT LLQQLMktkk sdlgmqsatv
1379 1389 1399 1409
GIDVKDWPIq irdkrkrdLV LNVWDFAGRE EFYSTHPhfm
1419 1429 1439 1449
tqRALYLAVY DLSKGQAEVD AMKPWLFNIK ARASSSPVIL
1459 1469 1479 1489
VGTHLDVSDE KQRKACMSKI TKELLNKRGF PAIRDYHFVN
1499 1509 1519 1529
ATEESDALAK LRKTIINESL NFKIRDQLVV GQLIPDCYVE
1539 1549 1559 1569
LEKIILSERK NVPIEFPVID RKRLLQLVRE NQLQLDENEL
1579 1589 1599 1609
PHAVHFLNES GVLLHFQdpA LQLSDLYFVE PKWLCKIMAQ
1619 1629 1639 1649
ILTVkvegcp khpkGIISRR DVEKFLSKKR KFPKNYMSQY
1659 1669 1679 1689
FKLLEKFQIA LPIGEEYLLV PSSLSDHRPV IELPHCENSE
1699 1709 1719 1729
IIIRLYEMPY FPMGFWSRLI NRLLEISPYM LsgreraLRP
1739 1749 1759 1769
NRMYWRQGIY LNWSPEAYCL VGSEVLDNHP ESFLKITVPS
1779 1789 1799 1809
CRKGCILLGQ VVDHIDSLME EWFPGLLeid icgegetLLK
1819 1829 1839 1849
KWALYSFNDG EEHQKILLDD LMKKAEEGDL LVNPDQPRLT
1859 1869 1879 1889
IPISQIAPDL ILADLPRNIM LNNDELEFEQ APEFLLGDGS
1899 1909 1919 1929
FGSVYRAAYE GEEVAVKIFN KHTSLRLLRQ ELVVLCHLHH
1939 1949 1959 1969
PSLISLLAAG IRPRMLVMEL ASKGSLDRLL QQDKASLTRT
1979 1989 1999 2009
LQHRIALHVA DGLRYLHSAM IIYRDLKPHN VLLFTLYPNA
2019 2029 2039 2049
AIIAKIADYG iaqyccrmgi ktsegtPGFR APEVARGNVI
2059 2069 2079 2089
YNQQADVYSF GLLLYDILTT GGRIVEGLKF PNEFDELEIQ
2099 2109 2119 2129
GKLPDPVKEY GCAPWPMVEK LIKQCLKENP QERPTSAQVF
2139 2149 2159 2169
DILNSAELVC LTRRILLPKN VIVECMVATH HnsrnASIWL
2179 2189 2199 2209
GCGHTDRGQL SFLDLNTEGY TSEEVADSRI LCLALVHLPV
2219 2229 2239 2249
EKESWIVSGT QSGTLLVINT EDGKKRHTLE KMTDSVTCLY
2259 2269 2279 2289
Cnsfskqskq kNFLLVGTAD GKLAIFEDKT VKLKGAAPLK
2299 2309 2319 2329
ILNIGNVSTP LMCLSEStns terNVMWGGC GTKIFSFSND
2339 2349 2359 2369
FTIQKLIETR TSQLFSYAAF SDSNIITVVV DTALYIAKQN
2379 2389 2399 2409
SPVVEVWDKK TEKLCGLIDC VHFLREVMvk enkeskhkMS
2419 2429 2439 2449
YSGRVKTLCL QKNTALWIGT GGGHILLLDL STRRLIRVIY
2459 2469 2479 2489
NFCNSVRVMM TAQLGSLKNV MLVLGYNRkn tegtqkqkEI
2499 2509 2519
QSCLTVWDIN LPHEVQNLEK HIEVRKELAE KMRRTSve
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1343