8TXZ

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)
Group: TKL
Uniprot: LRRK2_HUMAN
Organism: Homo sapiens
Domain boundary: 1875 - 2134
Resolu: 3.05

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in A1N Type1 1334 - 2522 0
Representative sequence - Chain A
1343 1353 1363 1373
RMKLMIVGNT GsgKTTLLQQ lmktkksdlg mqsATVGIDV
1383 1393 1403 1413
KDWpiqirdk rkrdlvLNVW DFAGREEFYS THPHFMTQRA
1423 1433 1443 1453
LYLAVYDLsk gqaevdamKP WLFNIKARAS SSPVILVGTh
1463 1473 1483 1493
ldvsdekqrk acmskitkel lnkrgfPAIR DYHFVnatee
1503 1513 1523 1533
sdalaklrkt iineslnfki rdqlvvgqli pdcyvelEKI
1543 1553 1563 1573
ILSERKNVPI EFPVIDRKRL LQlvrenqlq ldeNELPHAV
1583 1593 1603 1613
HFLNESGVLL HFQDPALQLS DLYFVEPKWL CKIMAQILTV
1623 1633 1643 1653
kvegcpkhPK GIISRRDVEK Flskkrkfpk nYMSQYFKLL
1663 1673 1683 1693
EKFQIALPIG EEYLLVPSSL SDHRPVIELP HCENSEIIIR
1703 1713 1723 1733
LYEMPYFPMG FWSRLINRLL EISPYMLSGr erALRPNRMY
1743 1753 1763 1773
WRQGIYLNWS PEAYCLVGSE VLDNHPESFL KITVPSCRKG
1783 1793 1803 1813
CILLGQVVDH IDSLMEEWFP GLLeidicge geTLLKKWAL
1823 1833 1843 1853
YSFNDGEEHQ KILLDDLMKK AEEGDLLVNp dqprltIPIS
1863 1873 1883 1893
QIAPDLILAD LPRNIMLNND ELEFEQAPEF LLGDGSFGSV
1903 1913 1923 1933
YRAAYEGEEV AVKIFNkHTS LRLLRQELVV LCHLHHPSLI
1943 1953 1963 1973
SLLAAGIRPR MLVMELASKG SLDRLLQQDK ASLTRTLQHR
1983 1993 2003 2013
IALHVADGLR YLHSAMIIYR DLKPHNVLLF TLYPNAAIIA
2023 2033 2043 2053
KIADYGIAQY CCRMGIKTSE GTPGFRAPEV ARGNVIYNQQ
2063 2073 2083 2093
ADVYSFGLLL YDILTTGGRI VEGLKFPNEF DELEiQGKLP
2103 2113 2123 2133
DPVKEYGCAP WPMVEKLIKQ CLKENPQERP TSAQVFDILN
2143 2153 2163 2173
SAELVCLTRR ILLPKNVIVE CMVAThhnsr nASIWLGcgh
2183 2193 2203 2213
tdrgqLSFLD LNTEGYtsee vadsrilCLA lvhlpvekes
2223 2233 2243 2253
wivsgtqsgt llvintedgk krhtlekmtd svtCLYCnsf
2263 2273 2283 2293
skqskqknfL LVGtadgkla ifedktvklk gaaplkilni
2303 2313 2323 2333
gnvstplmCL SEStnsterN VMWGGCGTKI FSFsndftiq
2343 2353 2363 2373
klietrtsql fsyaafsdsn IITVVVDTAL YIAKQNSPVV
2383 2393 2403 2413
EVWDKKTEKL CGLIDCVHFL REVMvkenke skhkMSYSGR
2423 2433 2443 2453
VKTLCLQKNT ALWIGTGGGH ILLLDLSTRr LIRVIYNFCN
2463 2473 2483 2493
SVRVMMTAQL gsLKNVMLVL GYNrkntegt qkqkeiQSCL
2503 2513 2523
TVWDINLPHE VQNLEKHIEV RKELAEKMRr tsve
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None