8SMC

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)
Group: TKL
Uniprot: LRRK2_HUMAN
Organism: Homo sapiens
Domain boundary: 1875 - 2134
Resolu: 4.02

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
C Inactive DFGin BLAminus in-out in-in TVT Type1 1329 - 2527 0
Representative sequence - Chain C
1336 1346 1356 1366
kkAVPYNRMK LMIVGNTGSG KTTLLQQLMK tkksdlgmQS
1376 1386 1396 1406
ATVGIDVKDW PIQIRDKRKR DLVLNVWDFA GREEFYSTHP
1416 1426 1436 1446
HFMTQRALYL AVYDLSKGQA EVDAMKPWLF NIKARASSSP
1456 1466 1476 1486
VILVGTHLDV SDEKQRKACM SKITkellnk rGFPAIRDYH
1496 1506 1516 1526
FVNATEESDA LAKLRKTIIN ESLNFKIRDQ LVVGQLIPDC
1536 1546 1556 1566
YVELEKIILS ERKNVPIEFP VIDRKRLLQL VRENQLQLDE
1576 1586 1596 1606
NELPHAVHFL NESGVLLHFQ DPALQLSDLY FVEPKWLCKI
1616 1626 1636 1646
MAQILTVkve gcpkhpkgii srrdvekfls kkrkfpkNYm
1656 1666 1676 1686
TQYFKLlekf qialpigeeY LLVPSSLSDH RPVIELPHCE
1696 1706 1716 1726
NSEIIIRLYE MPYFPMGFWS RLINRLLEIS Pymlsgrera
1736 1746 1756 1766
lrPNRRYWRQ GIYLNWSPEA YCLVGSEVLD NHPESFLKIT
1776 1786 1796 1806
VPSCRKGCIL LGQVVDHIDS LMEEWFPGLL eidicgeget
1816 1826 1836 1846
LLKKWALYSF NDGEEHQKIL LDDLMKKAEE GDLLVNPDQP
1856 1866 1876 1886
RLTIPISQIA PDLILADLPR NIMLNNDELE FEQAPEFLLG
1896 1906 1916 1926
DGSFGSVYRA AYEGEEVAVK IFNKHTSLRL LRQELVVLCH
1936 1946 1956 1966
LHHPSLISLL AAGIRPRMLV MELASKGSLD RLLQQDKASL
1976 1986 1996 2006
TRTLQHRIAL HVADGLRYLH SAMIIYRDLK PHNVLLFTLY
2016 2026 2036 2046
PNAAIIAKIA DYGIAQYCCR MGIKTSEGTP GFRAPEVARG
2056 2066 2076 2086
NVIYNQQADV YSFGLLLYDI LTTGGRIVEG LKFPNEFDEL
2096 2106 2116 2126
EIQGKLPDPV KEYGCAPWPM VEKLIKQCLK ENPQERPTSA
2136 2146 2156 2166
QVFDILNSAE LVCLTRRILL PKNVIVECMV ATHHNSRNAS
2176 2186 2196 2206
IWLGCGHTDR GQLSFLDLNT EGYTSEEVAD SRILCLALVH
2216 2226 2236 2246
LPVEKESWIV SGTQSGTLLV INTEDGKKRH TLEKMTDSVT
2256 2266 2276 2286
CLYCnsfskq skQKNFLLVG TADGKLAIFE DKTVKLKGAA
2296 2306 2316 2326
PLKILNIGNV STPLMCLSES TNSTERNVMW GGCGTKIFSF
2336 2346 2356 2366
SNDFTIQKLI ETRTsqlfsy aAFSDSNIIT VVVDTALYIA
2376 2386 2396 2406
KQNSPVVEVW DKKTEKLCGL IDCVHFLREV Tvkenkeskh
2416 2426 2436 2446
ktSYSGRVKT LCLQKNTALW IGTGGGHILL LDLSTRRLIR
2456 2466 2476 2486
VIYNFCNSVR VMMTAQLGSL KNVMLVLGYN Rkntegtqkq
2496 2506 2516 2526
KEIQSCLTVW DINLPHEVQN LEKHIEVRKE LAEKMRRTSV

E
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None