8TZH

LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)
Group: TKL
Uniprot: LRRK2_HUMAN
Organism: Homo sapiens
Domain boundary: 1875 - 2134
Resolu: 3.9

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-out none-in A1N Type1 627 - 2522 14
Representative sequence - Chain A
10 20 30 40
masgscqgce edeetlkkli vrlnnvqegk qietlvqile
50 60 70 80
dllvftyser asklfqgkni hvpllivlds ymrvasvqqv
90 100 110 120
gwsllcklie vcpgtmqslm gpqdvgndwe vlgvhqlilk
130 140 150 160
mltvhnasvn lsviglktld llltsgkitl lildeesdif
170 180 190 200
mlifdamhsf pandevqklg ckalhvlfer vseeqltefv
210 220 230 240
enkdymills altnfkdeee ivlhvlhclh slaipcnnve
250 260 270 280
vlmsgnvrcy nivveamkaf pmseriqevs ccllhrltlg
290 300 310 320
nffnilvlne vhefvvkavq qypenaalqi salsclallt
330 340 350 360
etiflnqdle eknenqendd egeedklfwl eacykaltwh
370 380 390 400
rknkhvqeaa cwalnnllmy qnslhekigd edghfpahre
410 420 430 440
vmlsmlmhss skevfqasan alstlleqnv nfrkillskg
450 460 470 480
ihlnvlelmq khihspevae sgckmlnhlf egsntsldim
490 500 510 520
aavvpkiltv mkrhetslpv qlealrailh fivpgmpees
530 540 550 560
redtefhhkl nmvkkqcfkn dihklvlaal nrfignpgiq
570 580 590 600
kcglkvissi vhfpdaleml slegamdsvl htlqmypddq
610 620 630 640
eiqclglsli gylitkknvf igtghlLAKI LVSSLYRFKD
650 660 670 680
VAEIQTKGfQ TILAIlklsa sfsKLLVHHS FDLVIFHQMS
690 700 710 720
SNImeqkDQQ FLNLCCKCFA KVAmddyLKN VMLERACDQN
730 740 750 760
NSIMVECLLL LGAdANQAke gsSLICQVCE KESSPKLVEL
770 780 790 800
LLNSGSREQD VRKALTISIG KGDSQIISLL LRRLALDVAN
810 820 830 840
NSICLGGFCI GKVEPSWLGP LFPdktsnlr kqtNIASTLA
850 860 870 880
RMVIRYQmks aveegtasgs dgnfsedvls kfdewtfipd
890 900 910 920
ssmdsvfaqs ddldsegseg sflvkkksns isvgefyrda
930 940 950 960
vlqrcspnlq rhsnslgpif dhedllkrkr kilssddslr
970 980 990 1000
ssklqshmrh sdsisslase reYITSLDLS ANELRDIDAL
1010 1020 1030 1040
SQKCCISVHL EHLEKLELHQ NALTSFPQQL CETLKSLTHL
1050 1060 1070 1080
DLHSNKFTSF PSYLLKMSCI ANLDVSRNDI GPSVVLDPTV
1090 1100 1110 1120
KCPTLKQFNL SYNQLSFVPE NLTDVVEKLE QLILEGNKIS
1130 1140 1150 1160
GICSPLRLKE LKILNLSKNH ISSLSENFLE ACPKVESFSA
1170 1180 1190 1200
RMNFLAAMPF LPPSMTILKL SQNKFSCIPE AILNLPHLRS
1210 1220 1230 1240
LDMSSNDIQY LPGPAHWKSL NLRELLFSHN QISILDLSEK
1250 1260 1270 1280
AYLWSRVEKL HLSHNKLKEI PPEIGCLENL TSLDVSYNLE
1290 1300 1310 1320
LRSFPNEMGK LSKIWDLPLD ELHlnfdfkh igcKAKDIIR
1330 1340 1350 1360
FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLmktkks
1370 1380 1390 1400
dlgmqsaTVG IDVKDWPIqi rdkrkrdLVL NVWDFAGREE
1410 1420 1430 1440
FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA
1450 1460 1470 1480
RASSSPVILV GTHLDVsdek qrKACMSKIT KELLNKRGFP
1490 1500 1510 1520
AIRDYHFVNA teeSDALAKL RKTIINESLN FKIRDQLVVG
1530 1540 1550 1560
QLIPDCYVEL EKIILSERKN VPIEFPVIDR KRLLQLVren
1570 1580 1590 1600
QLQLDENELP HAVHFLNESG VLLHFqdpal qlSDLYFVEP
1610 1620 1630 1640
KWLCKIMAQI LTvkvegcpk hPKGIISRRD VEKflskkrk
1650 1660 1670 1680
fpKNYMSQYF KLLEKFQial pigeeylLVP SSLSDhrpvi
1690 1700 1710 1720
elphCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPyml
1730 1740 1750 1760
sgreraLRPN RMYWRQGIYL NWSPEAYCLV GSEVLDNHPE
1770 1780 1790 1800
SFLKITVPSC RKGCILLGQV VDHIDSLMEE WFPGLLEIdi
1810 1820 1830 1840
cgegETLLKK WALYSFNdge ehqKILLDDL MKKAEEGDLL
1850 1860 1870 1880
VNPDQPRLTI PISQIAPDLI LADLPRNIML NNDELEFEQA
1890 1900 1910 1920
PEFLLGDGSF GSVYRAAYEG EEVAVKIFNk HTSLRLLRQE
1930 1940 1950 1960
LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ
1970 1980 1990 2000
QDKASLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV
2010 2020 2030 2040
LLFTLYPNAA IIAKIADYGi aqyccrmgik tseGTPGFRA
2050 2060 2070 2080
PEVARgnviy nQQADVYSFG LLLYDILTTG GRIVEGLKFP
2090 2100 2110 2120
NEFDELEIQG KLPDPVKEYG CAPWPMVEKL IKQCLKENPQ
2130 2140 2150 2160
ERPTSAQVFD ILNSAELVCL TRRILLPKNV IVECMVAthh
2170 2180 2190 2200
nsrnaSIWLG cghtdrGQLS FLDLntegyt seevadsRIL
2210 2220 2230 2240
CLALvhlpve keswIVSGTQ SGTLLVINte dgkkrhtlek
2250 2260 2270 2280
mtdSVTCLYC nsfskqskqk nfLLVGTADG KLAIFedktv
2290 2300 2310 2320
klkgaaPLKI LNIGnvsTPL MCLSEStnst ernVMWGGCG
2330 2340 2350 2360
TKIFSFsndf TIQKLIETRT SQLFSYAAFS DSNIITVVVD
2370 2380 2390 2400
TALYIAKQNS PVVEVWDKKT EKLCGLIDCV HFLREVmvke
2410 2420 2430 2440
nkeskhkmSY SGRVKTLCLQ KNTALWIGTG GGHILLLDLS
2450 2460 2470 2480
TRRLIRVIYN FCNSVRVMMT AQLgslKNVM LVLGYNRknt
2490 2500 2510 2520
egtqkqkEIQ SCLTVWDINL PHEVQNLEKH IEVRKELAEK

MRrtsve
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None