ITK (Tyrosine-protein kinase ITK/TSK)

Group: TYR
Uniprot: ITK_HUMAN
Domain boundary: 363 - 614


Total number of chains: 57
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-Q08881-K1A
DFGin BLAplus 25 4RFMA
DFGin BLBplus 20 4HCUA
DFGin None 10 4PQNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q08881-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 355 - 620 None None 0
3QGYB 2.1 None DFGin BLAminus in-in none-none L7O Type1 357 - 616 None None 16
3MIYB 1.67 Inactive DFGin BLAplus in-out none-none B49 Type1 357 - 619 C477S,E614A,E617A None 18
4MF1A 2.113 Inactive DFGin BLAplus in-out none-none 29Y Type1 357 - 619 C477S,E614A,E617A None 17
4MF1B 2.113 Inactive DFGin BLAplus in-out out-out 29Y Type1 357 - 619 C477S,E614A,E617A None 14
4RFMA 2.1 Inactive DFGin BLAplus out-out out-out 3P6 Type1 357 - 618 C477S,E614A,E617A None 14
4KIOA 2.18 Inactive DFGin BLAplus out-out none-none G5K Type1 357 - 619 Y512E None 16
4KIOB 2.18 Inactive DFGin BLAplus out-out none-none G5K Type1 357 - 619 Y512E None 16
4KIOD 2.18 Inactive DFGin BLAplus out-out none-none G6K Type1 357 - 618 Y512E None 17
4L7SA 2.03 Inactive DFGin BLAplus in-out none-none G7K Type1 357 - 620 Y512E None 16
4L7SB 2.03 Inactive DFGin BLAplus in-out none-none G7K Type1 357 - 620 Y512E None 16
4MF0A 2.67 Inactive DFGin BLAplus out-out none-none 29Z Type1 357 - 619 Y512E None 16
4PP9A 2.58 Inactive DFGin BLAplus in-out none-none 2VT Type1 357 - 619 Y512E None 18
4PP9B 2.58 Inactive DFGin BLAplus in-out none-none 2VT Type1 357 - 619 Y512E None 17
4QD6A 2.45 Inactive DFGin BLAplus out-out none-none 30T Type1 357 - 619 Y512E None 16
3QGWA 2.1 Inactive DFGin BLAplus out-out none-out PQC Type1 358 - 618 None None 17
3QGYA 2.1 Inactive DFGin BLAplus out-out none-none PQC Type1 357 - 618 None None 18
3V5JA 2.59 Inactive DFGin BLAplus out-none none-none 0F2 Type1 357 - 618 None None 18
3V5LA 1.86 Inactive DFGin BLAplus out-none none-none 0G1 Type1 357 - 616 None None 16
3V5LB 1.86 Inactive DFGin BLAplus out-out none-none 0G1 Type1 357 - 619 None None 16
3V5LC 1.86 Inactive DFGin BLAplus in-out none-out 0G1 Type1 357 - 616 None None 15
3V5LD 1.86 Inactive DFGin BLAplus out-out none-out 0G1 Type1 357 - 619 None None 16
3V8TA 2.0 Inactive DFGin BLAplus out-out none-none 477 Type1 357 - 618 None None 17
3V8TB 2.0 Inactive DFGin BLAplus out-none none-none 477 Type1 357 - 619 None None 16
3V8WA 2.27 Inactive DFGin BLAplus out-none none-none 0G2 Type1 357 - 619 None None 18
3V8WB 2.27 Inactive DFGin BLAplus out-none none-none 0G2 Type1 357 - 619 None None 18
4KIOC 2.18 Inactive DFGin BLAplus out-out none-out G6K G5K Type1 Type1 357 - 620 Y512E None 15
1SNXA 3.2 Inactive DFGin BLBplus out-out none-none No_ligand No_ligand 357 - 619 None None 18
1SNXB 3.2 Inactive DFGin BLBplus out-out none-none No_ligand No_ligand 357 - 619 None None 18
3MJ2A 1.9 Inactive DFGin BLBplus out-out out-out MJG Type1 357 - 615 C477S,E614A,E617A None 0
4PPAA 2.67 Inactive DFGin BLBplus out-out none-none 2VU Type1 357 - 619 Y512E None 18
4PPAB 2.67 Inactive DFGin BLBplus out-out none-none 2VU Type1 357 - 619 Y512E None 18
4PPBA 2.82 Inactive DFGin BLBplus out-out none-none 2VV Type1 357 - 619 Y512E None 18
4PPBB 2.82 Inactive DFGin BLBplus out-out none-none 2VV Type1 357 - 619 Y512E None 18
4QD6B 2.45 Inactive DFGin BLBplus out-out none-none 30T Type1 357 - 619 Y512E None 16
1SM2A 2.3 Inactive DFGin BLBplus out-out none-none STU Type1 357 - 619 None None 18
1SNUA 2.5 Inactive DFGin BLBplus out-out none-none STU Type1 357 - 619 None None 18
4HCTA 1.48 Inactive DFGin BLBplus out-out out-out 18R Type1 354 - 618 K596R None 0
4HCUA 1.43 Inactive DFGin BLBplus out-out out-out 13L Type1 356 - 618 K596R None 0
4HCVA 1.48 Inactive DFGin BLBplus out-out out-out 13J Type1 356 - 618 K596R None 0
3T9TA 1.65 Inactive DFGin BLBplus out-out out-out IAQ Type1 356 - 618 F435T,K596R None 0
4M0YA 1.7 Inactive DFGin BLBplus out-out out-out M0Y M0Y Type1 Type3 356 - 618 None None 0
4M14A 1.55 Inactive DFGin BLBplus out-out out-out QWS QWS Type1 Type3 355 - 617 None None 0
4M12A 2.15 Inactive DFGin BLBplus out-out out-out 1YZ Type3 355 - 618 None None 0
4M13A 1.85 Inactive DFGin BLBplus out-out out-out 1E0 Type3 355 - 618 None None 0
4M0ZA 2.0 Inactive DFGin BLBplus out-out out-out M0Z M0Z Type3 Type1 355 - 618 None None 0
4M15A 1.52 Inactive DFGin BLBplus out-out out-out QWS ADP Type3 Type1 355 - 617 None None 0
3MIYA 1.67 Inactive DFGin None in-out none-none B49 Type1 357 - 619 C477S,E614A,E617A None 19
3MJ1A 1.72 Inactive DFGin None out-out none-none 614 Type1 357 - 615 C477S,E614A,E617A None 19
4PQNA 1.71 Inactive DFGin None in-out none-out 2W6 Type1 357 - 615 C477S,E614A,E617A None 17
4MF0B 2.67 Inactive DFGin None out-out none-none 29Z Type1 357 - 619 Y512E None 19
4PPCA 2.95 Inactive DFGin None out-out none-none 2VW Type1 357 - 619 Y512E None 19
4PPCB 2.95 Inactive DFGin None out-out none-none 2VW Type1 357 - 619 Y512E None 19
3QGWB 2.1 Inactive DFGin None in-out none-none L7A Type1 358 - 616 None None 19
1SM2B 2.3 Inactive DFGin None out-out none-none STU Type1 358 - 617 None None 19
1SNUB 2.5 Inactive DFGin None out-out none-none STU Type1 358 - 617 None None 19
3V5JB 2.59 Inactive DFGin None out-none none-none 0F2 Type1 357 - 620 None None 19

ITK (Tyrosine-protein kinase ITK/TSK)

Group: TYR
Total number of chains: 57
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-Q08881-K1A
DFGin BLAplus 25 4RFMA
DFGin BLBplus 20 4HCUA
DFGin None 10 4PQNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ITK_HUMAN AF-Q08881-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 355 - 620 None None 0
Homo sapiens ITK_HUMAN 3QGYB 2.1 None DFGin BLAminus in-in none-none L7O Type1 357 - 616 None None 16
Homo sapiens ITK_HUMAN 3MIYB 1.67 Inactive DFGin BLAplus in-out none-none B49 Type1 357 - 619 C477S,E614A,E617A None 18
Homo sapiens ITK_HUMAN 4MF1A 2.113 Inactive DFGin BLAplus in-out none-none 29Y Type1 357 - 619 C477S,E614A,E617A None 17
Homo sapiens ITK_HUMAN 4MF1B 2.113 Inactive DFGin BLAplus in-out out-out 29Y Type1 357 - 619 C477S,E614A,E617A None 14
Homo sapiens ITK_HUMAN 4RFMA 2.1 Inactive DFGin BLAplus out-out out-out 3P6 Type1 357 - 618 C477S,E614A,E617A None 14
Homo sapiens ITK_HUMAN 4KIOA 2.18 Inactive DFGin BLAplus out-out none-none G5K Type1 357 - 619 Y512E None 16
Homo sapiens ITK_HUMAN 4KIOB 2.18 Inactive DFGin BLAplus out-out none-none G5K Type1 357 - 619 Y512E None 16
Homo sapiens ITK_HUMAN 4KIOD 2.18 Inactive DFGin BLAplus out-out none-none G6K Type1 357 - 618 Y512E None 17
Homo sapiens ITK_HUMAN 4L7SA 2.03 Inactive DFGin BLAplus in-out none-none G7K Type1 357 - 620 Y512E None 16
Homo sapiens ITK_HUMAN 4L7SB 2.03 Inactive DFGin BLAplus in-out none-none G7K Type1 357 - 620 Y512E None 16
Homo sapiens ITK_HUMAN 4MF0A 2.67 Inactive DFGin BLAplus out-out none-none 29Z Type1 357 - 619 Y512E None 16
Homo sapiens ITK_HUMAN 4PP9A 2.58 Inactive DFGin BLAplus in-out none-none 2VT Type1 357 - 619 Y512E None 18
Homo sapiens ITK_HUMAN 4PP9B 2.58 Inactive DFGin BLAplus in-out none-none 2VT Type1 357 - 619 Y512E None 17
Homo sapiens ITK_HUMAN 4QD6A 2.45 Inactive DFGin BLAplus out-out none-none 30T Type1 357 - 619 Y512E None 16
Homo sapiens ITK_HUMAN 3QGWA 2.1 Inactive DFGin BLAplus out-out none-out PQC Type1 358 - 618 None None 17
Homo sapiens ITK_HUMAN 3QGYA 2.1 Inactive DFGin BLAplus out-out none-none PQC Type1 357 - 618 None None 18
Homo sapiens ITK_HUMAN 3V5JA 2.59 Inactive DFGin BLAplus out-none none-none 0F2 Type1 357 - 618 None None 18
Homo sapiens ITK_HUMAN 3V5LA 1.86 Inactive DFGin BLAplus out-none none-none 0G1 Type1 357 - 616 None None 16
Homo sapiens ITK_HUMAN 3V5LB 1.86 Inactive DFGin BLAplus out-out none-none 0G1 Type1 357 - 619 None None 16
Homo sapiens ITK_HUMAN 3V5LC 1.86 Inactive DFGin BLAplus in-out none-out 0G1 Type1 357 - 616 None None 15
Homo sapiens ITK_HUMAN 3V5LD 1.86 Inactive DFGin BLAplus out-out none-out 0G1 Type1 357 - 619 None None 16
Homo sapiens ITK_HUMAN 3V8TA 2.0 Inactive DFGin BLAplus out-out none-none 477 Type1 357 - 618 None None 17
Homo sapiens ITK_HUMAN 3V8TB 2.0 Inactive DFGin BLAplus out-none none-none 477 Type1 357 - 619 None None 16
Homo sapiens ITK_HUMAN 3V8WA 2.27 Inactive DFGin BLAplus out-none none-none 0G2 Type1 357 - 619 None None 18
Homo sapiens ITK_HUMAN 3V8WB 2.27 Inactive DFGin BLAplus out-none none-none 0G2 Type1 357 - 619 None None 18
Homo sapiens ITK_HUMAN 4KIOC 2.18 Inactive DFGin BLAplus out-out none-out G6K G5K Type1 Type1 357 - 620 Y512E None 15
Homo sapiens ITK_HUMAN 1SNXA 3.2 Inactive DFGin BLBplus out-out none-none No_ligand No_ligand 357 - 619 None None 18
Homo sapiens ITK_HUMAN 1SNXB 3.2 Inactive DFGin BLBplus out-out none-none No_ligand No_ligand 357 - 619 None None 18
Homo sapiens ITK_HUMAN 3MJ2A 1.9 Inactive DFGin BLBplus out-out out-out MJG Type1 357 - 615 C477S,E614A,E617A None 0
Homo sapiens ITK_HUMAN 4PPAA 2.67 Inactive DFGin BLBplus out-out none-none 2VU Type1 357 - 619 Y512E None 18
Homo sapiens ITK_HUMAN 4PPAB 2.67 Inactive DFGin BLBplus out-out none-none 2VU Type1 357 - 619 Y512E None 18
Homo sapiens ITK_HUMAN 4PPBA 2.82 Inactive DFGin BLBplus out-out none-none 2VV Type1 357 - 619 Y512E None 18
Homo sapiens ITK_HUMAN 4PPBB 2.82 Inactive DFGin BLBplus out-out none-none 2VV Type1 357 - 619 Y512E None 18
Homo sapiens ITK_HUMAN 4QD6B 2.45 Inactive DFGin BLBplus out-out none-none 30T Type1 357 - 619 Y512E None 16
Homo sapiens ITK_HUMAN 1SM2A 2.3 Inactive DFGin BLBplus out-out none-none STU Type1 357 - 619 None None 18
Homo sapiens ITK_HUMAN 1SNUA 2.5 Inactive DFGin BLBplus out-out none-none STU Type1 357 - 619 None None 18
Homo sapiens ITK_HUMAN 4HCTA 1.48 Inactive DFGin BLBplus out-out out-out 18R Type1 354 - 618 K596R None 0
Homo sapiens ITK_HUMAN 4HCUA 1.43 Inactive DFGin BLBplus out-out out-out 13L Type1 356 - 618 K596R None 0
Homo sapiens ITK_HUMAN 4HCVA 1.48 Inactive DFGin BLBplus out-out out-out 13J Type1 356 - 618 K596R None 0
Homo sapiens ITK_HUMAN 3T9TA 1.65 Inactive DFGin BLBplus out-out out-out IAQ Type1 356 - 618 F435T,K596R None 0
Homo sapiens ITK_HUMAN 4M0YA 1.7 Inactive DFGin BLBplus out-out out-out M0Y M0Y Type1 Type3 356 - 618 None None 0
Homo sapiens ITK_HUMAN 4M14A 1.55 Inactive DFGin BLBplus out-out out-out QWS QWS Type1 Type3 355 - 617 None None 0
Homo sapiens ITK_HUMAN 4M12A 2.15 Inactive DFGin BLBplus out-out out-out 1YZ Type3 355 - 618 None None 0
Homo sapiens ITK_HUMAN 4M13A 1.85 Inactive DFGin BLBplus out-out out-out 1E0 Type3 355 - 618 None None 0
Homo sapiens ITK_HUMAN 4M0ZA 2.0 Inactive DFGin BLBplus out-out out-out M0Z M0Z Type3 Type1 355 - 618 None None 0
Homo sapiens ITK_HUMAN 4M15A 1.52 Inactive DFGin BLBplus out-out out-out QWS ADP Type3 Type1 355 - 617 None None 0
Homo sapiens ITK_HUMAN 3MIYA 1.67 Inactive DFGin None in-out none-none B49 Type1 357 - 619 C477S,E614A,E617A None 19
Homo sapiens ITK_HUMAN 3MJ1A 1.72 Inactive DFGin None out-out none-none 614 Type1 357 - 615 C477S,E614A,E617A None 19
Homo sapiens ITK_HUMAN 4PQNA 1.71 Inactive DFGin None in-out none-out 2W6 Type1 357 - 615 C477S,E614A,E617A None 17
Homo sapiens ITK_HUMAN 4MF0B 2.67 Inactive DFGin None out-out none-none 29Z Type1 357 - 619 Y512E None 19
Homo sapiens ITK_HUMAN 4PPCA 2.95 Inactive DFGin None out-out none-none 2VW Type1 357 - 619 Y512E None 19
Homo sapiens ITK_HUMAN 4PPCB 2.95 Inactive DFGin None out-out none-none 2VW Type1 357 - 619 Y512E None 19
Homo sapiens ITK_HUMAN 3QGWB 2.1 Inactive DFGin None in-out none-none L7A Type1 358 - 616 None None 19
Homo sapiens ITK_HUMAN 1SM2B 2.3 Inactive DFGin None out-out none-none STU Type1 358 - 617 None None 19
Homo sapiens ITK_HUMAN 1SNUB 2.5 Inactive DFGin None out-out none-none STU Type1 358 - 617 None None 19
Homo sapiens ITK_HUMAN 3V5JB 2.59 Inactive DFGin None out-none none-none 0F2 Type1 357 - 620 None None 19

ITK (Tyrosine-protein kinase ITK/TSK)

No non-human structures known.