3MIY

ITK (Tyrosine-protein kinase ITK/TSK)
Group: TYR
Uniprot: ITK_HUMAN
Organism: Homo sapiens
Domain boundary: 363 - 614
Resolu: 1.67

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-out none-none B49 Type1 357 - 619 19
B Inactive DFGin BLAplus in-out none-none B49 Type1 357 - 619 18
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       364        374        384        394 
GSVIDPSELT FVQEIGSGqf GLVHLGYWLN KDKVAIKTIr 
       404        414        424        434 
egamSEEDFI EEAEVMMKLS HPKLVQLYGV CLEQAPICLV 
       444        454        464        474 
FEFMEHGCLS DYLRTQRGLF AAETLLGMCL DVCEGMAYLE 
       484        494        504        514 
EASVIHRDLA ARNCLVGENQ VIKVSDFGmt rfvlddqyts 
       524        534        544        554 
stgtkfPVKW ASPEVFSFSR YSSKSDVWSF GVLMWEVFSE 
       564        574        584        594 
GKIPYENRSN SEVVEDISTG FRLYKPRLAS THVYQIMNHC 
       604        614 
WKERPEDRPA FSRLLRQLAA IAASGl
Lower-case residues are disordered in structure.
Mutations: C477S,E614A,E617A
Phosphorylation: None