4HCU

ITK (Tyrosine-protein kinase ITK/TSK)
Group: TYR
Uniprot: ITK_HUMAN
Organism: Homo sapiens
Domain boundary: 363 - 614
Resolu: 1.43

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-out 13L Type1 356 - 618 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       361        371        381        391 
gsgkWVIDPS ELTFVQEIGS GQFGLVHLGY WLNKDKVAIK 
       401        411        421        431 
TIREGAMSEE DFIEEAEVMM KLSHPKLVQL YGVCLEQAPI 
       441        451        461        471 
CLVFEFMEHG CLSDYLRTQR GLFAAETLLG MCLDVCEGMA 
       481        491        501        511 
YLEEACVIHR DLAARNCLVG ENQVIKVSDF GMTRFVLDDQ 
       521        531        541        551 
YTSSTGTKFP VKWASPEVFS FSRYSSKSDV WSFGVLMWEV 
       561        571        581        591 
FSEGKIPYEN RSNSEVVEDI STGFRLYKPR LASTHVYQIM 
       601        611 
NHCWRERPED RPAFSRLLRQ LAEIAESgl
Lower-case residues are disordered in structure.
Mutations: K596R
Phosphorylation: None