Ligand: I46

Total number of chains: 10
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 30.0% 3K3IA
DFGout None 3 30.0% 3K3JA
DFGin BLBplus 2 20.0% 3HL7A
DFGin None 2 20.0% 3HP2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK14 MK14_HUMAN 3HL7A 1.88 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoni APEdist_nnno I47, I46 Type1, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HLLA 1.95 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaoni APEdist_nnoo I45, I46, PO2 Type1, Allosteric, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP2A 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo P36, I46, I46 Type1, Allosteric, Allosteric 4 - 355 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HP5A 2.3 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 52P, I46, I46 Type1, Allosteric, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6QDZA 1.73 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno I46, HYK Allosteric, Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6QE1A 1.85 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno I46, HYW Allosteric, Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3K3IA 1.7 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno JZJ, I46, I46 Type3, Allosteric, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2YISA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIS, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2YIWA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIW, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3K3JA 1.995 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4C, I46 Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14

Ligand: I46

Total number of chains: 10
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 30.0% 3K3IA
DFGout None 3 30.0% 3K3JA
DFGin BLBplus 2 20.0% 3HL7A
DFGin None 2 20.0% 3HP2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK14 MK14_HUMAN 3HL7A 1.88 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoni APEdist_nnno I47, I46 Type1, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HLLA 1.95 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaoni APEdist_nnoo I45, I46, PO2 Type1, Allosteric, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HP2A 2.15 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo P36, I46, I46 Type1, Allosteric, Allosteric 4 - 355 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HP5A 2.3 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 52P, I46, I46 Type1, Allosteric, Allosteric 6 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6QDZA 1.73 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno I46, HYK Allosteric, Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6QE1A 1.85 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno I46, HYW Allosteric, Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3K3IA 1.7 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno JZJ, I46, I46 Type3, Allosteric, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2YISA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIS, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2YIWA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIW, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3K3JA 1.995 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4C, I46 Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens

Ligand: I46

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism