Protein kinases in complex with FE

Total number of genes: 6
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 7 4U8ZA
DFGin BLBminus 1 6T41A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC AKT1 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase 3MV5A 2.47 Active DFGin BLAminus in-in in-in XFE Type1
AGC AKT1 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase 3MVHA 2.01 Active DFGin BLAminus in-in in-in WFE Type1
AGC PRKACA KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha 3MVJA 2.49 Active DFGin BLAminus in-in in-in XFE Type1
AGC PRKACA KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha 3MVJE 2.49 Active DFGin BLAminus in-in in-in XFE Type1
CAMK CHEK1 CHK1_HUMAN Serine/threonine-protein kinase Chk1 5OP5A 1.9 Active DFGin BLAminus in-in in-in 3FE Type1
CMGC CDK8 CDK8_HUMAN Cyclin-dependent kinase 8 6T41A 2.45 Inactive DFGin BLBminus in-in out-none MFE Type1
STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4U8ZA 1.63 Active DFGin BLAminus in-in in-in 3FE Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 6ZCSA 1.47 Active DFGin BLAminus in-in in-in QFE Type1

Protein kinases in complex with FE

Total number of genes: 8
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLAminus 7 4U8ZA
DFGin ABAminus 1 7Q52AAA
DFGin BLBminus 1 6T41A
DFGout None 1 4EL9A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens AGC AKT1 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase 3MV5A 2.47 Active DFGin BLAminus in-in in-in XFE Type1
Homo sapiens AGC AKT1 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase 3MVHA 2.01 Active DFGin BLAminus in-in in-in WFE Type1
Homo sapiens AGC PRKACA KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha 3MVJA 2.49 Active DFGin BLAminus in-in in-in XFE Type1
Homo sapiens AGC PRKACA KAPCA_HUMAN cAMP-dependent protein kinase catalytic subunit alpha 3MVJE 2.49 Active DFGin BLAminus in-in in-in XFE Type1
Homo sapiens CAMK CHEK1 CHK1_HUMAN Serine/threonine-protein kinase Chk1 5OP5A 1.9 Active DFGin BLAminus in-in in-in 3FE Type1
Homo sapiens CMGC CDK8 CDK8_HUMAN Cyclin-dependent kinase 8 6T41A 2.45 Inactive DFGin BLBminus in-in out-none MFE Type1
Homo sapiens STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4U8ZA 1.63 Active DFGin BLAminus in-in in-in 3FE Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 6ZCSA 1.47 Active DFGin BLAminus in-in in-in QFE Type1
Mus musculus AGC RPS6KA3 KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 4EL9A 1.55 Inactive DFGout None none-none out-out AFE Type1
Mycobacterium tuberculosis OTHER PKNG PKNG_MYCTU Serine/threonine-protein kinase PknG 7Q52AAA 2.35 Inactive DFGin ABAminus out-out in-in FE 8ZC Allosteric Type1

Protein kinases in complex with FE

Total number of genes: 2
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGin ABAminus 1 7Q52AAA
DFGout None 1 4EL9A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Mus musculus AGC RPS6KA3 KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 4EL9A 1.55 Inactive DFGout None none-none out-out AFE Type1
Mycobacterium tuberculosis OTHER PKNG PKNG_MYCTU Serine/threonine-protein kinase PknG 7Q52AAA 2.35 Inactive DFGin ABAminus out-out in-in FE 8ZC Allosteric Type1