AGC_PRKCI (Protein kinase C iota type)

Total number of chains: 24
Active chains: 14
Uniprot: KPCI_HUMAN
Kinase Domain Residues: 254 - 522
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 83.3% AF-P41743-K1A
DFGin ABAminus 4 16.7% 8R3XA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
5LIHA 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 248 - 588 0 TPO412,TPO564 None Protein kinase C iota type
5LIHB 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
5LI9A 1.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 248 - 589 0 TPO412,TPO564 None Protein kinase C iota type
5LI1A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 589 0 TPO412,SEP484,TPO564 None Protein kinase C iota type
AF-P41743-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 246 - 530 0 None None Protein kinase C iota type
AF-P41743-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 246 - 530 0 None None Protein kinase C iota type
3A8XA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
3A8XB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
9EJKB 3.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
9EJLB 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 25 - 588 0 TPO412,TPO564 None Protein kinase C iota type
3ZH8A 2.739 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii C58 Type1 248 - 590 0 TPO412,TPO564 C595S Protein kinase C iota type
3ZH8B 2.739 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii C58 Type1 248 - 589 0 TPO412,TPO564 C595S Protein kinase C iota type
3ZH8C 2.739 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii C58 Type1 248 - 588 0 TPO412,TPO564 C595S Protein kinase C iota type
1ZRZA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
8R3YI 3.68 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 585 0 TPO412,TPO564 None Protein kinase C iota type
8R3XA 2.591 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
8R3XB 2.591 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 587 0 TPO412,TPO564 None Protein kinase C iota type
6ILZA 3.261 Inactive DFGin‑ABAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 254 - 587 0 TPO412,TPO564 None Protein kinase C iota type
3A8WA 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
3A8WB 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
9EJMB 3.33 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type
6ILZC 3.261 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 254 - 587 0 TPO412,TPO564 None Protein kinase C iota type
6ILZE 3.261 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 255 - 587 0 TPO412,TPO564 None Protein kinase C iota type
6ILZG 3.261 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 254 - 587 0 TPO412,TPO564 None Protein kinase C iota type

AGC_PRKCI (Protein kinase C iota type)

Total number of chains: 25
Active chains: 14
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 84.0% AF-P41743-K1A
DFGin ABAminus 4 16.0% 8R3XA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KPCI_HUMAN 5LIHA 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 248 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 5LIHB 3.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 5LI9A 1.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ACP ATPlike 248 - 589 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 5LI1A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 589 0 TPO412,SEP484,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN AF-P41743-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 246 - 530 0 None None Protein kinase C iota type Homo sapiens
KPCI_HUMAN AF-P41743-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 246 - 530 0 None None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3A8XA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3A8XB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 9EJKB 3.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 9EJLB 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 25 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3ZH8A 2.739 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii C58 Type1 248 - 590 0 TPO412,TPO564 C595S Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3ZH8B 2.739 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii C58 Type1 248 - 589 0 TPO412,TPO564 C595S Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3ZH8C 2.739 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii C58 Type1 248 - 588 0 TPO412,TPO564 C595S Protein kinase C iota type Homo sapiens
KPCI_HUMAN 1ZRZA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI1 Type1 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 8R3YI 3.68 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 585 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 8R3XA 2.591 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 8R3XB 2.591 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 249 - 587 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 6ILZA 3.261 Inactive DFGin‑ABAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 254 - 587 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3A8WA 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 3A8WB 2.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 9EJMB 3.33 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 249 - 588 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 6ILZC 3.261 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 254 - 587 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 6ILZE 3.261 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 255 - 587 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_HUMAN 6ILZG 3.261 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AFU Type1 254 - 587 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
KPCI_MOUSE 4DC2A 2.4 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 248 - 586 0 TPO563 None Protein kinase C iota type Mus musculus

AGC_PRKCI (Protein kinase C iota type)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 4DC2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KPCI_MOUSE 4DC2A 2.4 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 248 - 586 0 TPO563 None Protein kinase C iota type Mus musculus