AGC_PRKCI (Protein kinase C iota type)

Total number of chains: 24
Active chains: 14
Uniprot: KPCI_HUMAN
Kinase Domain Residues: 254 - 522
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 83.3% AF-P41743-K1A
DFGin ABAminus 4 16.7% 8R3XA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRKCI 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.4026 11.8632 BLAminus -129.58, 178.7 63.64, 84.98 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.1779 Saltbr-in 3.0311 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.1093 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.9856 APE10-dist-in 5.4207 APE9-dist-in 3.5596 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349.0 326.0 15 28 28 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.3101 11.8759 BLAminus -129.18, 178.42 63.46, 84.62 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.7197 Saltbr-in 2.5445 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.1408 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.3287 APE11-dist-in 11.2559 APE10-dist-in 5.6928 APE9-dist-in 3.7423 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349.0 320.0 20 28 28 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.6347 12.6326 BLAminus -139.17, 172.4 72.31, 78.11 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.3605 Saltbr-in 2.6142 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.8096 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.8117 APE11-dist-in 11.9487 APE10-dist-in 6.4318 APE9-dist-in 3.8358 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350.0 330.0 12 28 28 0 [[254, 522]] 1.0 5li9 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.0788 11.9615 BLAminus -129.24, 176.98 73.22, 90.17 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.8162 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.9747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.7516 APE11-dist-in 11.8219 APE10-dist-in 6.3097 APE9-dist-in 3.5172 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354.0 332.0 10 28 28 0 [[254, 522]] 1.0 5li1 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI AF-P41743-K1A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.4472 12.4054 BLAminus -131.03, -165.82 44.28, 65.55 -76.76, 9.18 306.63, 118.08 -56.74, -36.72 in-in in 8.4499 Saltbr-in 2.6229 HRD-in -77.0, -41.44 60.49, -7.42 in-in-in SNCiii in-in ActLoopNT-in 2.8629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.06, 173.77 APE9-dihe-na 111.64, 163.54 APE8-dihe-in -68.62, 127.52 APE8-rot-in 295.24 APE67-dihe-in -71.1, -16.65 -47.7, -40.44 APE12-dist-in 8.6522 APE11-dist-in 11.8918 APE10-dist-in 6.1851 APE9-dist-in 3.578 None None None AF2 -1.0 1.0 1.0 A 285.0 285.0 0 28 28 0 [[254, 522]] 1.0 AF-P41743-K1 AGC_PRKCI_HUMAN AGC 5.6e-96 326.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI AF-P41743-K3A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.0666 12.2627 BLAminus -132.42, 177.52 58.72, 87.78 -95.71, 10.36 309.96, 125.27 -59.78, -23.56 in-in in 8.4339 Saltbr-in 2.6086 HRD-in -81.78, -44.52 65.41, -3.76 in-in-in SNCiii in-in ActLoopNT-in 2.9246 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.16, 168.09 APE9-dihe-na 113.77, 166.26 APE8-dihe-in -77.9, 128.97 APE8-rot-in 291.1 APE67-dihe-in -65.12, -20.54 -47.59, -43.64 APE12-dist-in 8.7699 APE11-dist-in 11.6461 APE10-dist-in 6.1157 APE9-dist-in 3.2695 None None None AF2 -1.0 1.0 1.0 A 285.0 285.0 0 28 28 0 [[254, 522]] 1.0 AF-P41743-K3 AGC_PRKCI_HUMAN AGC 5.6e-96 326.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3A8XA P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.4791 12.3058 BLAminus -133.56, 171.16 66.18, 84.73 -94.69, 12.13 305.3, 131.59 -63.13, -17.58 in-in in 8.7839 Saltbr-in 2.575 HRD-in -71.12, -56.95 73.87, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.7574 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -172.63, 123.28 APE9-dihe-na 133.81, -165.17 APE8-dihe-in -100.11, 125.82 APE8-rot-in 300.75 APE67-dihe-in -55.67, -25.11 -46.23, -50.55 APE12-dist-in 8.5344 APE11-dist-in 11.6846 APE10-dist-in 6.739 APE9-dist-in 3.7976 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 A 345.0 333.0 7 28 28 0 [[254, 522]] 1.0 3a8x AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3A8XB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.1959 12.3632 BLAminus -134.81, 172.86 61.29, 86.65 -89.58, 25.14 305.87, 129.78 -77.51, -26.88 in-in in 8.8541 Saltbr-in 3.1414 HRD-in -71.84, -53.34 75.49, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.7549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.8, 129.32 APE9-dihe-na 125.34, -174.85 APE8-dihe-in -94.58, 120.99 APE8-rot-in 296.51 APE67-dihe-in -60.75, -26.64 -37.16, -45.74 APE12-dist-in 8.8503 APE11-dist-in 11.8742 APE10-dist-in 6.8554 APE9-dist-in 3.878 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 B 345.0 327.0 13 28 28 0 [[254, 522]] 1.0 3a8x AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 9EJKB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 6.3217 12.883 BLAminus -140.76, 171.15 65.08, 85.19 -104.47, 31.46 313.7, 135.04 -76.2, -15.07 in-in in 9.0042 Saltbr-in 3.5326 HRD-in -63.1, -53.44 69.1, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.4548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 154.63 APE9-dihe-na 128.06, 155.44 APE8-dihe-in -56.67, 121.19 APE8-rot-in 310.7 APE67-dihe-in -58.25, -24.63 -54.37, -39.36 APE12-dist-in 9.3768 APE11-dist-in 12.3851 APE10-dist-in 6.7264 APE9-dist-in 4.1258 None TPO412,TPO564 TPO412,TPO564 EM 3.08 999.0 999.0 B 596.0 320.0 9 28 28 0 [[254, 522]] 1.0 9ejk AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 9EJLB P41743 25 588 596.0 No_ligand No_ligand Active DFGin 5.7802 13.0097 BLAminus -138.05, 176.56 63.52, 82.24 -100.53, 29.28 318.31, 120.09 -73.2, -15.29 in-in in 8.7098 Saltbr-in 3.1072 HRD-in -63.42, -52.9 69.14, -4.84 in-in-in SNCiii in-in ActLoopNT-in 3.3905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.27, 154.98 APE9-dihe-na 129.08, 155.07 APE8-dihe-in -56.55, 121.43 APE8-rot-in 311.13 APE67-dihe-in -59.47, -23.97 -53.96, -40.11 APE12-dist-in 9.615 APE11-dist-in 12.4024 APE10-dist-in 6.733 APE9-dist-in 4.1274 None TPO412,TPO564 TPO412,TPO564 EM 3.48 999.0 999.0 B 596.0 506.0 0 28 28 0 [[254, 522]] 1.0 9ejl AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3ZH8A P41743 248 590 596.0 C58:61582 Type1 Active DFGin 5.5559 12.0016 BLAminus -130.37, -178.04 51.18, 83.54 -87.27, 17.91 304.14, 111.3 -61.33, -13.38 in-in in 9.3249 Saltbr-in 3.3408 HRD-in -65.53, -55.38 66.64, 24.69 in-in-in SNCiii in-in ActLoopNT-in 2.8162 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 178.63 APE9-dihe-na 118.81, -170.03 APE8-dihe-in -107.2, 114.73 APE8-rot-in 305.39 APE67-dihe-in -50.56, -25.42 -31.13, -57.8 APE12-dist-in 8.7234 APE11-dist-in 11.7887 APE10-dist-in 6.1951 APE9-dist-in 3.8565 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 A 349.0 320.0 8 28 28 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3ZH8B P41743 248 589 596.0 C58:61581 Type1 Active DFGin 5.5045 12.0361 BLAminus -129.65, -179.53 51.29, 82.99 -86.76, 19.25 305.39, 112.3 -61.07, -14.24 in-in in 9.3302 Saltbr-in 3.2561 HRD-in -64.76, -55.3 66.61, 24.25 in-in-in SNCiii in-in ActLoopNT-in 2.8262 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, 178.62 APE9-dihe-na 117.31, -170.26 APE8-dihe-in -107.45, 114.14 APE8-rot-in 306.11 APE67-dihe-in -50.63, -24.48 -30.49, -58.16 APE12-dist-in 8.8392 APE11-dist-in 11.985 APE10-dist-in 6.3695 APE9-dist-in 3.8643 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 B 349.0 319.0 8 28 28 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3ZH8C P41743 248 588 596.0 C58:61580 Type1 Active DFGin 5.7962 12.0734 BLAminus -128.69, -178.25 53.53, 81.54 -88.45, 18.44 303.41, 111.5 -61.77, -13.25 in-in in 9.3671 Saltbr-in 3.2747 HRD-in -64.18, -55.09 66.76, 24.05 in-in-in SNCiii in-in ActLoopNT-in 2.8637 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.52, 178.89 APE9-dihe-na 116.26, -170.7 APE8-dihe-in -106.06, 114.81 APE8-rot-in 304.72 APE67-dihe-in -49.82, -25.77 -29.67, -57.17 APE12-dist-in 8.9277 APE11-dist-in 11.7784 APE10-dist-in 6.17 APE9-dist-in 3.7858 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 C 349.0 314.0 8 28 28 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 1ZRZA P41743 249 588 596.0 BI1:61000 Type1 Active DFGin 5.4066 12.5714 BLAminus -130.8, 174.67 64.45, 118.73 -128.08, 29.21 300.88, 154.48 -95.06, 36.97 in-in in 8.489 Saltbr-in 2.7733 HRD-in -48.25, -53.67 63.34, -15.36 in-in-in SNCiii in-in ActLoopNT-in 2.9907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.12, -165.87 APE9-dihe-na 92.97, 155.51 APE8-dihe-in -67.22, 110.52 APE8-rot-in 321.88 APE67-dihe-in -51.87, -24.47 -26.14, -57.0 APE12-dist-in 8.3992 APE11-dist-in 11.8236 APE10-dist-in 6.4557 APE9-dist-in 3.7889 None TPO412,TPO564 TPO412,TPO564 XRAY 3.0 0.249 0.333 A 364.0 312.0 9 28 28 0 [[254, 522]] 1.0 1zrz AGC_PRKCI_HUMAN AGC 2.4e-95 324.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.3715 12.4884 ABAminus -142.84, 3.21 -114.63, 115.49 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.8164 Saltbr-out 4.2411 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.9084 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.8632 APE11-dist-in 11.2821 APE10-dist-in 5.8559 APE9-dist-in 3.4976 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338.0 338.0 0 28 28 0 [[254, 522]] 1.0 8r3y AGC_PRKCI_HUMAN AGC 1e-95 325.7 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 8R3XA P41743 249 588 596.0 No_ligand No_ligand Inactive DFGin 5.7894 12.6569 ABAminus -120.55, -62.73 -83.47, 105.52 -97.36, 7.54 309.71, 135.25 -66.01, -26.35 in-out in 8.6748 Saltbr-out 4.0977 HRD-in -74.93, -54.1 72.92, 4.26 out-in-in SNCoii in-in ActLoopNT-in 2.9439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.73, 162.47 APE9-dihe-na 134.4, -143.72 APE8-dihe-in -134.56, 123.62 APE8-rot-in 297.56 APE67-dihe-in -56.39, -41.71 -45.2, -41.49 APE12-dist-in 8.8065 APE11-dist-in 11.8421 APE10-dist-in 6.1153 APE9-dist-in 3.3924 None TPO412,TPO564 TPO412,TPO564 XRAY 2.591 0.234 0.269 A 356.0 340.0 0 28 28 0 [[254, 522]] 1.0 8r3x AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 8R3XB P41743 249 587 596.0 No_ligand No_ligand Inactive DFGin 5.4118 12.6748 ABAminus -124.75, -60.53 -82.56, 104.3 -97.59, 10.1 309.28, 136.28 -63.5, -26.7 in-in in 9.32 Saltbr-in 2.5787 HRD-in -74.34, -54.48 73.27, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.9511 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.88, 161.36 APE9-dihe-na 132.08, -145.04 APE8-dihe-in -133.89, 124.43 APE8-rot-in 298.47 APE67-dihe-in -59.19, -41.22 -42.94, -43.02 APE12-dist-in 8.7779 APE11-dist-in 11.8424 APE10-dist-in 6.1065 APE9-dist-in 3.3993 None TPO412,TPO564 TPO412,TPO564 XRAY 2.591 0.234 0.269 B 356.0 339.0 0 28 28 0 [[254, 522]] 1.0 8r3x AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 6ILZA P41743 254 587 596.0 AFU:601 Type1 Inactive DFGin 5.5236 12.2745 ABAminus -101.22, -50.19 -115.29, 89.28 -72.99, 31.3 307.01, 139.52 -87.24, -45.36 in-none in 8.8393 Saltbr-none 999.0 HRD-in -53.35, -56.43 62.18, -10.31 none-in-in SNCnii in-in ActLoopNT-in 2.9601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.77, 144.04 APE9-dihe-na -176.45, 171.24 APE8-dihe-in -98.87, 140.23 APE8-rot-in 302.07 APE67-dihe-in -72.12, -45.53 -55.29, -41.31 APE12-dist-in 8.3513 APE11-dist-in 11.182 APE10-dist-in 5.4801 APE9-dist-in 4.1128 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 A 345.0 320.0 14 28 28 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.1739 12.3776 BLAminus -132.69, 170.49 67.34, 88.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.3565 Saltbr-out 3.8823 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.7712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.7688 APE11-dist-in 11.7671 APE10-dist-in 6.2593 APE9-dist-in 3.6656 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345.0 325.0 15 28 28 0 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.2569 12.3236 BLAminus -133.61, 172.63 64.84, 89.8 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.1924 Saltbr-out 3.9771 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.9967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.7599 APE11-dist-in 11.7256 APE10-dist-in 6.5394 APE9-dist-in 3.7699 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345.0 326.0 14 28 25 3 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2004 12.8648 BLAminus -142.99, -166.55 58.77, 70.37 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.1664 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.1518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.6026 APE11-dist-in 12.2532 APE10-dist-in 6.5946 APE9-dist-in 3.9282 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596.0 322.0 9 28 28 0 [[254, 522]] 1.0 9ejm AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 6ILZC P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.3497 12.5654 BLAminus -139.32, -164.03 47.55, 59.28 -80.83, 61.9 308.74, 123.06 -106.89, -43.16 in-none in 9.1093 Saltbr-none 999.0 HRD-in -73.5, -52.72 54.13, -0.86 none-in-in SNCnii in-in ActLoopNT-in 2.8907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -173.36, 149.93 APE9-dihe-na 148.31, -160.27 APE8-dihe-in -114.43, 136.89 APE8-rot-in 309.46 APE67-dihe-in -57.11, -55.6 -58.53, -45.22 APE12-dist-in 9.0548 APE11-dist-in 10.952 APE10-dist-in 5.4779 APE9-dist-in 4.0012 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 C 345.0 317.0 15 28 28 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 6ILZE P41743 255 587 596.0 AFU:601 Type1 None DFGin 6.9572 12.8457 BLAminus -133.5, 178.86 66.81, 59.27 -86.16, 63.15 305.7, 112.11 -113.68, -42.34 in-none in 8.722 Saltbr-none 999.0 HRD-in -57.41, -56.51 65.78, 5.3 none-in-in SNCnii in-in ActLoopNT-in 3.2058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.18, 118.96 APE9-dihe-na -158.88, 157.43 APE8-dihe-in -112.73, 131.93 APE8-rot-in 318.3 APE67-dihe-in -62.09, -40.72 -61.87, -47.3 APE12-dist-in 9.3047 APE11-dist-in 10.8433 APE10-dist-in 5.4363 APE9-dist-in 4.9473 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 E 345.0 316.0 16 28 28 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI 6ILZG P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.2078 12.2572 BLAminus -148.76, -174.16 47.03, 68.4 -82.07, 61.51 312.36, 107.63 -107.63, -40.38 in-none in 8.9225 Saltbr-none 999.0 HRD-in -68.38, -50.26 58.54, -1.28 none-in-in SNCnii in-in ActLoopNT-in 2.9854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 131.51 APE9-dihe-na -176.4, 176.09 APE8-dihe-in -116.21, 141.66 APE8-rot-in 312.23 APE67-dihe-in -65.11, -53.96 -57.73, -45.37 APE12-dist-in 8.8274 APE11-dist-in 10.5977 APE10-dist-in 4.9364 APE9-dist-in 4.5806 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 G 345.0 315.0 14 28 28 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type

AGC_PRKCI (Protein kinase C iota type)

Total number of chains: 25
Active chains: 14
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 84.0% AF-P41743-K1A
DFGin ABAminus 4 16.0% 8R3XA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.4026 11.8632 BLAminus -129.58, 178.7 63.64, 84.98 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.1779 Saltbr-in 3.0311 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.1093 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.9856 APE10-dist-in 5.4207 APE9-dist-in 3.5596 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349.0 326.0 15 28 28 0 [[254, 522]] 1.0 5lih Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.3101 11.8759 BLAminus -129.18, 178.42 63.46, 84.62 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.7197 Saltbr-in 2.5445 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.1408 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.3287 APE11-dist-in 11.2559 APE10-dist-in 5.6928 APE9-dist-in 3.7423 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349.0 320.0 20 28 28 0 [[254, 522]] 1.0 5lih Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.6347 12.6326 BLAminus -139.17, 172.4 72.31, 78.11 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.3605 Saltbr-in 2.6142 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.8096 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.8117 APE11-dist-in 11.9487 APE10-dist-in 6.4318 APE9-dist-in 3.8358 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350.0 330.0 12 28 28 0 [[254, 522]] 1.0 5li9 Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.0788 11.9615 BLAminus -129.24, 176.98 73.22, 90.17 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.8162 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.9747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.7516 APE11-dist-in 11.8219 APE10-dist-in 6.3097 APE9-dist-in 3.5172 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354.0 332.0 10 28 28 0 [[254, 522]] 1.0 5li1 Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN AF-P41743-K1A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.4472 12.4054 BLAminus -131.03, -165.82 44.28, 65.55 -76.76, 9.18 306.63, 118.08 -56.74, -36.72 in-in in 8.4499 Saltbr-in 2.6229 HRD-in -77.0, -41.44 60.49, -7.42 in-in-in SNCiii in-in ActLoopNT-in 2.8629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.06, 173.77 APE9-dihe-na 111.64, 163.54 APE8-dihe-in -68.62, 127.52 APE8-rot-in 295.24 APE67-dihe-in -71.1, -16.65 -47.7, -40.44 APE12-dist-in 8.6522 APE11-dist-in 11.8918 APE10-dist-in 6.1851 APE9-dist-in 3.578 None None None AF2 -1.0 1.0 1.0 A 285.0 285.0 0 28 28 0 [[254, 522]] 1.0 AF-P41743-K1 Homo sapiens AGC_PRKCI_HUMAN AGC 5.6e-96 326.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN AF-P41743-K3A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.0666 12.2627 BLAminus -132.42, 177.52 58.72, 87.78 -95.71, 10.36 309.96, 125.27 -59.78, -23.56 in-in in 8.4339 Saltbr-in 2.6086 HRD-in -81.78, -44.52 65.41, -3.76 in-in-in SNCiii in-in ActLoopNT-in 2.9246 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.16, 168.09 APE9-dihe-na 113.77, 166.26 APE8-dihe-in -77.9, 128.97 APE8-rot-in 291.1 APE67-dihe-in -65.12, -20.54 -47.59, -43.64 APE12-dist-in 8.7699 APE11-dist-in 11.6461 APE10-dist-in 6.1157 APE9-dist-in 3.2695 None None None AF2 -1.0 1.0 1.0 A 285.0 285.0 0 28 28 0 [[254, 522]] 1.0 AF-P41743-K3 Homo sapiens AGC_PRKCI_HUMAN AGC 5.6e-96 326.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3A8XA P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.4791 12.3058 BLAminus -133.56, 171.16 66.18, 84.73 -94.69, 12.13 305.3, 131.59 -63.13, -17.58 in-in in 8.7839 Saltbr-in 2.575 HRD-in -71.12, -56.95 73.87, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.7574 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -172.63, 123.28 APE9-dihe-na 133.81, -165.17 APE8-dihe-in -100.11, 125.82 APE8-rot-in 300.75 APE67-dihe-in -55.67, -25.11 -46.23, -50.55 APE12-dist-in 8.5344 APE11-dist-in 11.6846 APE10-dist-in 6.739 APE9-dist-in 3.7976 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 A 345.0 333.0 7 28 28 0 [[254, 522]] 1.0 3a8x Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3A8XB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.1959 12.3632 BLAminus -134.81, 172.86 61.29, 86.65 -89.58, 25.14 305.87, 129.78 -77.51, -26.88 in-in in 8.8541 Saltbr-in 3.1414 HRD-in -71.84, -53.34 75.49, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.7549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.8, 129.32 APE9-dihe-na 125.34, -174.85 APE8-dihe-in -94.58, 120.99 APE8-rot-in 296.51 APE67-dihe-in -60.75, -26.64 -37.16, -45.74 APE12-dist-in 8.8503 APE11-dist-in 11.8742 APE10-dist-in 6.8554 APE9-dist-in 3.878 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 B 345.0 327.0 13 28 28 0 [[254, 522]] 1.0 3a8x Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 9EJKB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 6.3217 12.883 BLAminus -140.76, 171.15 65.08, 85.19 -104.47, 31.46 313.7, 135.04 -76.2, -15.07 in-in in 9.0042 Saltbr-in 3.5326 HRD-in -63.1, -53.44 69.1, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.4548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 154.63 APE9-dihe-na 128.06, 155.44 APE8-dihe-in -56.67, 121.19 APE8-rot-in 310.7 APE67-dihe-in -58.25, -24.63 -54.37, -39.36 APE12-dist-in 9.3768 APE11-dist-in 12.3851 APE10-dist-in 6.7264 APE9-dist-in 4.1258 None TPO412,TPO564 TPO412,TPO564 EM 3.08 999.0 999.0 B 596.0 320.0 9 28 28 0 [[254, 522]] 1.0 9ejk Homo sapiens AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 9EJLB P41743 25 588 596.0 No_ligand No_ligand Active DFGin 5.7802 13.0097 BLAminus -138.05, 176.56 63.52, 82.24 -100.53, 29.28 318.31, 120.09 -73.2, -15.29 in-in in 8.7098 Saltbr-in 3.1072 HRD-in -63.42, -52.9 69.14, -4.84 in-in-in SNCiii in-in ActLoopNT-in 3.3905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.27, 154.98 APE9-dihe-na 129.08, 155.07 APE8-dihe-in -56.55, 121.43 APE8-rot-in 311.13 APE67-dihe-in -59.47, -23.97 -53.96, -40.11 APE12-dist-in 9.615 APE11-dist-in 12.4024 APE10-dist-in 6.733 APE9-dist-in 4.1274 None TPO412,TPO564 TPO412,TPO564 EM 3.48 999.0 999.0 B 596.0 506.0 0 28 28 0 [[254, 522]] 1.0 9ejl Homo sapiens AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3ZH8A P41743 248 590 596.0 C58:61582 Type1 Active DFGin 5.5559 12.0016 BLAminus -130.37, -178.04 51.18, 83.54 -87.27, 17.91 304.14, 111.3 -61.33, -13.38 in-in in 9.3249 Saltbr-in 3.3408 HRD-in -65.53, -55.38 66.64, 24.69 in-in-in SNCiii in-in ActLoopNT-in 2.8162 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 178.63 APE9-dihe-na 118.81, -170.03 APE8-dihe-in -107.2, 114.73 APE8-rot-in 305.39 APE67-dihe-in -50.56, -25.42 -31.13, -57.8 APE12-dist-in 8.7234 APE11-dist-in 11.7887 APE10-dist-in 6.1951 APE9-dist-in 3.8565 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 A 349.0 320.0 8 28 28 0 [[254, 522]] 1.0 3zh8 Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3ZH8B P41743 248 589 596.0 C58:61581 Type1 Active DFGin 5.5045 12.0361 BLAminus -129.65, -179.53 51.29, 82.99 -86.76, 19.25 305.39, 112.3 -61.07, -14.24 in-in in 9.3302 Saltbr-in 3.2561 HRD-in -64.76, -55.3 66.61, 24.25 in-in-in SNCiii in-in ActLoopNT-in 2.8262 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, 178.62 APE9-dihe-na 117.31, -170.26 APE8-dihe-in -107.45, 114.14 APE8-rot-in 306.11 APE67-dihe-in -50.63, -24.48 -30.49, -58.16 APE12-dist-in 8.8392 APE11-dist-in 11.985 APE10-dist-in 6.3695 APE9-dist-in 3.8643 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 B 349.0 319.0 8 28 28 0 [[254, 522]] 1.0 3zh8 Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3ZH8C P41743 248 588 596.0 C58:61580 Type1 Active DFGin 5.7962 12.0734 BLAminus -128.69, -178.25 53.53, 81.54 -88.45, 18.44 303.41, 111.5 -61.77, -13.25 in-in in 9.3671 Saltbr-in 3.2747 HRD-in -64.18, -55.09 66.76, 24.05 in-in-in SNCiii in-in ActLoopNT-in 2.8637 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.52, 178.89 APE9-dihe-na 116.26, -170.7 APE8-dihe-in -106.06, 114.81 APE8-rot-in 304.72 APE67-dihe-in -49.82, -25.77 -29.67, -57.17 APE12-dist-in 8.9277 APE11-dist-in 11.7784 APE10-dist-in 6.17 APE9-dist-in 3.7858 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 C 349.0 314.0 8 28 28 0 [[254, 522]] 1.0 3zh8 Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 1ZRZA P41743 249 588 596.0 BI1:61000 Type1 Active DFGin 5.4066 12.5714 BLAminus -130.8, 174.67 64.45, 118.73 -128.08, 29.21 300.88, 154.48 -95.06, 36.97 in-in in 8.489 Saltbr-in 2.7733 HRD-in -48.25, -53.67 63.34, -15.36 in-in-in SNCiii in-in ActLoopNT-in 2.9907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.12, -165.87 APE9-dihe-na 92.97, 155.51 APE8-dihe-in -67.22, 110.52 APE8-rot-in 321.88 APE67-dihe-in -51.87, -24.47 -26.14, -57.0 APE12-dist-in 8.3992 APE11-dist-in 11.8236 APE10-dist-in 6.4557 APE9-dist-in 3.7889 None TPO412,TPO564 TPO412,TPO564 XRAY 3.0 0.249 0.333 A 364.0 312.0 9 28 28 0 [[254, 522]] 1.0 1zrz Homo sapiens AGC_PRKCI_HUMAN AGC 2.4e-95 324.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.3715 12.4884 ABAminus -142.84, 3.21 -114.63, 115.49 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.8164 Saltbr-out 4.2411 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.9084 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.8632 APE11-dist-in 11.2821 APE10-dist-in 5.8559 APE9-dist-in 3.4976 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338.0 338.0 0 28 28 0 [[254, 522]] 1.0 8r3y Homo sapiens AGC_PRKCI_HUMAN AGC 1e-95 325.7 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 8R3XA P41743 249 588 596.0 No_ligand No_ligand Inactive DFGin 5.7894 12.6569 ABAminus -120.55, -62.73 -83.47, 105.52 -97.36, 7.54 309.71, 135.25 -66.01, -26.35 in-out in 8.6748 Saltbr-out 4.0977 HRD-in -74.93, -54.1 72.92, 4.26 out-in-in SNCoii in-in ActLoopNT-in 2.9439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.73, 162.47 APE9-dihe-na 134.4, -143.72 APE8-dihe-in -134.56, 123.62 APE8-rot-in 297.56 APE67-dihe-in -56.39, -41.71 -45.2, -41.49 APE12-dist-in 8.8065 APE11-dist-in 11.8421 APE10-dist-in 6.1153 APE9-dist-in 3.3924 None TPO412,TPO564 TPO412,TPO564 XRAY 2.591 0.234 0.269 A 356.0 340.0 0 28 28 0 [[254, 522]] 1.0 8r3x Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 8R3XB P41743 249 587 596.0 No_ligand No_ligand Inactive DFGin 5.4118 12.6748 ABAminus -124.75, -60.53 -82.56, 104.3 -97.59, 10.1 309.28, 136.28 -63.5, -26.7 in-in in 9.32 Saltbr-in 2.5787 HRD-in -74.34, -54.48 73.27, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.9511 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.88, 161.36 APE9-dihe-na 132.08, -145.04 APE8-dihe-in -133.89, 124.43 APE8-rot-in 298.47 APE67-dihe-in -59.19, -41.22 -42.94, -43.02 APE12-dist-in 8.7779 APE11-dist-in 11.8424 APE10-dist-in 6.1065 APE9-dist-in 3.3993 None TPO412,TPO564 TPO412,TPO564 XRAY 2.591 0.234 0.269 B 356.0 339.0 0 28 28 0 [[254, 522]] 1.0 8r3x Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 6ILZA P41743 254 587 596.0 AFU:601 Type1 Inactive DFGin 5.5236 12.2745 ABAminus -101.22, -50.19 -115.29, 89.28 -72.99, 31.3 307.01, 139.52 -87.24, -45.36 in-none in 8.8393 Saltbr-none 999.0 HRD-in -53.35, -56.43 62.18, -10.31 none-in-in SNCnii in-in ActLoopNT-in 2.9601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.77, 144.04 APE9-dihe-na -176.45, 171.24 APE8-dihe-in -98.87, 140.23 APE8-rot-in 302.07 APE67-dihe-in -72.12, -45.53 -55.29, -41.31 APE12-dist-in 8.3513 APE11-dist-in 11.182 APE10-dist-in 5.4801 APE9-dist-in 4.1128 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 A 345.0 320.0 14 28 28 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.1739 12.3776 BLAminus -132.69, 170.49 67.34, 88.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.3565 Saltbr-out 3.8823 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.7712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.7688 APE11-dist-in 11.7671 APE10-dist-in 6.2593 APE9-dist-in 3.6656 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345.0 325.0 15 28 28 0 [[254, 522]] 1.0 3a8w Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.2569 12.3236 BLAminus -133.61, 172.63 64.84, 89.8 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.1924 Saltbr-out 3.9771 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.9967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.7599 APE11-dist-in 11.7256 APE10-dist-in 6.5394 APE9-dist-in 3.7699 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345.0 326.0 14 28 25 3 [[254, 522]] 1.0 3a8w Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2004 12.8648 BLAminus -142.99, -166.55 58.77, 70.37 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.1664 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.1518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.6026 APE11-dist-in 12.2532 APE10-dist-in 6.5946 APE9-dist-in 3.9282 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596.0 322.0 9 28 28 0 [[254, 522]] 1.0 9ejm Homo sapiens AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 6ILZC P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.3497 12.5654 BLAminus -139.32, -164.03 47.55, 59.28 -80.83, 61.9 308.74, 123.06 -106.89, -43.16 in-none in 9.1093 Saltbr-none 999.0 HRD-in -73.5, -52.72 54.13, -0.86 none-in-in SNCnii in-in ActLoopNT-in 2.8907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -173.36, 149.93 APE9-dihe-na 148.31, -160.27 APE8-dihe-in -114.43, 136.89 APE8-rot-in 309.46 APE67-dihe-in -57.11, -55.6 -58.53, -45.22 APE12-dist-in 9.0548 APE11-dist-in 10.952 APE10-dist-in 5.4779 APE9-dist-in 4.0012 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 C 345.0 317.0 15 28 28 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 6ILZE P41743 255 587 596.0 AFU:601 Type1 None DFGin 6.9572 12.8457 BLAminus -133.5, 178.86 66.81, 59.27 -86.16, 63.15 305.7, 112.11 -113.68, -42.34 in-none in 8.722 Saltbr-none 999.0 HRD-in -57.41, -56.51 65.78, 5.3 none-in-in SNCnii in-in ActLoopNT-in 3.2058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.18, 118.96 APE9-dihe-na -158.88, 157.43 APE8-dihe-in -112.73, 131.93 APE8-rot-in 318.3 APE67-dihe-in -62.09, -40.72 -61.87, -47.3 APE12-dist-in 9.3047 APE11-dist-in 10.8433 APE10-dist-in 5.4363 APE9-dist-in 4.9473 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 E 345.0 316.0 16 28 28 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_HUMAN 6ILZG P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.2078 12.2572 BLAminus -148.76, -174.16 47.03, 68.4 -82.07, 61.51 312.36, 107.63 -107.63, -40.38 in-none in 8.9225 Saltbr-none 999.0 HRD-in -68.38, -50.26 58.54, -1.28 none-in-in SNCnii in-in ActLoopNT-in 2.9854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 131.51 APE9-dihe-na -176.4, 176.09 APE8-dihe-in -116.21, 141.66 APE8-rot-in 312.23 APE67-dihe-in -65.11, -53.96 -57.73, -45.37 APE12-dist-in 8.8274 APE11-dist-in 10.5977 APE10-dist-in 4.9364 APE9-dist-in 4.5806 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 G 345.0 315.0 14 28 28 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
PRKCI KPCI_MOUSE 4DC2A Q62074 248 586 595.0 ADE:60601 Type1 None DFGin 5.5144 11.5945 BLAminus -116.21, -173.67 60.87, 97.17 -103.56, 4.24 303.35, 138.78 -42.92, -43.52 in-none in 9.0991 Saltbr-none 999.0 HRD-in -77.29, -48.77 70.59, -5.86 none-in-in SNCnii in-in ActLoopNT-in 2.7891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.58, 165.79 APE9-dihe-na 134.32, -165.14 APE8-dihe-in -104.82, 125.13 APE8-rot-in 306.69 APE67-dihe-in -51.64, -27.58 -50.63, -43.23 APE12-dist-in 8.6109 APE11-dist-in 11.6064 APE10-dist-in 6.2195 APE9-dist-in 3.6877 None TPO563 TPO563 XRAY 2.4 0.176 0.241 A 396.0 329.0 10 28 28 0 [[253, 521]] 1.0 4dc2 Mus musculus AGC_PRKCI_MOUSE AGC 1.2e-94 322.3 1.0 260.0 260.0 394 395 396 398 400 282 301 305 374 376 375 377.0 434 422 417 416 415 414 413 412 411 332 Protein kinase C iota type

AGC_PRKCI (Protein kinase C iota type)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 4DC2A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRKCI KPCI_MOUSE 4DC2A Q62074 248 586 595.0 ADE:60601 Type1 None DFGin 5.5144 11.5945 BLAminus -116.21, -173.67 60.87, 97.17 -103.56, 4.24 303.35, 138.78 -42.92, -43.52 in-none in 9.0991 Saltbr-none 999.0 HRD-in -77.29, -48.77 70.59, -5.86 none-in-in SNCnii in-in ActLoopNT-in 2.7891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.58, 165.79 APE9-dihe-na 134.32, -165.14 APE8-dihe-in -104.82, 125.13 APE8-rot-in 306.69 APE67-dihe-in -51.64, -27.58 -50.63, -43.23 APE12-dist-in 8.6109 APE11-dist-in 11.6064 APE10-dist-in 6.2195 APE9-dist-in 3.6877 None TPO563 TPO563 XRAY 2.4 0.176 0.241 A 396.0 329.0 10 28 28 0 [[253, 521]] 1.0 4dc2 Mus musculus AGC_PRKCI_MOUSE AGC 1.2e-94 322.3 1.0 260.0 260.0 394 395 396 398 400 282 301 305 374 376 375 377.0 434 422 417 416 415 414 413 412 411 332 Protein kinase C iota type