CMGC_MAPK8 (Mitogen-activated protein kinase 8)

Total number of chains: 62
Active chains: 16
Uniprot: MK08_HUMAN
Kinase Domain Residues: 26 - 321
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 38 61.3% 8R5EA
DFGin BLAminus 21 33.9% AF-P45983-K1A
DFGin None 3 4.8% 2G01B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
3O2MA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
3O2MB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
3VUIA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C79V,C116S,C163A,C245S Mitogen-activated protein kinase 8
3VUHA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C116S,C163A,C245S Mitogen-activated protein kinase 8
3VUDA 3.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C245S Mitogen-activated protein kinase 8
3VUGA 3.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C116S,C245S Mitogen-activated protein kinase 8
3VUKA 2.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C79V,C116S,C137V,C163A,C245S Mitogen-activated protein kinase 8
AF-P45983-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 329 0 None None Mitogen-activated protein kinase 8
AF-P45983-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 329 0 None None Mitogen-activated protein kinase 8
3O17A 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 363 0 None T183E,Y185E Mitogen-activated protein kinase 8
3O17B 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 363 0 None T183E,Y185E Mitogen-activated protein kinase 8
2G01A 3.5 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii 73Q Type1 10 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
2H96A 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 893 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
2H96B 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 893 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
2NO3A 3.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 859 Type1 8 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
2NO3B 3.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 859 Type1 7 - 363 0 None T183E,Y185E Mitogen-activated protein kinase 8
6ZR5A 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 3 - 362 0 None None Mitogen-activated protein kinase 8
6ZR5B 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 4 - 362 0 None None Mitogen-activated protein kinase 8
2XRWA 1.33 Inactive DFGin‑ABAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 364 0 None None Mitogen-activated protein kinase 8
2XS0A 2.6 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ANP ATPlike 6 - 365 0 None T183V,Y185F Mitogen-activated protein kinase 8
4UX9A 2.34 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8
4UX9C 2.34 Inactive DFGin‑ABAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8
4UX9D 2.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_oioo ANP ATPlike 9 - 364 0 None None Mitogen-activated protein kinase 8
8R5EA 1.7 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP, Y6K ATPlike, Allosteric 5 - 363 0 None None Mitogen-activated protein kinase 8
1UKHA 2.35 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 9 - 363 0 None None Mitogen-activated protein kinase 8
4YR8A 2.4 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 8 - 362 0 None None Mitogen-activated protein kinase 8
4YR8C 2.4 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 10 - 362 0 None None Mitogen-activated protein kinase 8
4YR8E 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 7 - 362 0 None None Mitogen-activated protein kinase 8
4YR8F 2.4 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 10 - 362 0 None None Mitogen-activated protein kinase 8
6F5EB 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 7 - 362 0 None None Mitogen-activated protein kinase 8
8X5MA 2.0 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno Y4O Type1 7 - 363 0 None None Mitogen-activated protein kinase 8
8PT8A 2.78 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nioo A3O Type1 7 - 363 0 None None Mitogen-activated protein kinase 8
8PT8B 2.78 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_iioo A3O Type1 8 - 363 0 None None Mitogen-activated protein kinase 8
8PT8C 2.78 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo A3O Type1 7 - 362 0 None None Mitogen-activated protein kinase 8
8PT9A 2.7 Inactive DFGin‑ABAminus out-in out-out nonTYR APEdihe_aaooi APEdist_iooo DVI Type1 8 - 363 0 None None Mitogen-activated protein kinase 8
8PT9B 2.7 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aaioi APEdist_nioo DVI Type1 7 - 363 0 None None Mitogen-activated protein kinase 8
8PT9C 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo DVI Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
8PTAA 2.41 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iooo CIF Type1 8 - 363 0 None None Mitogen-activated protein kinase 8
8PTAB 2.41 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo CIF Type1 7 - 363 0 None None Mitogen-activated protein kinase 8
8PTAC 2.41 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo CIF Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
1UKIA 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanio APEdist_nnnn 537 Type1 9 - 363 0 None None Mitogen-activated protein kinase 8
4E73A 2.27 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 0NR Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
4G1WA 2.45 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn G1W Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
4HYSA 2.415 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1BJ Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
4HYUA 2.152 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1BK Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
4IZYA 2.3 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1J2 Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
3PZEA 2.0 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno CFK Type1 7 - 362 0 None None Mitogen-activated protein kinase 8
4L7FA 1.95 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo 1V5 Type1 7 - 362 0 None None Mitogen-activated protein kinase 8
3ELJA 1.8 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_oooo GS7 Type1 7 - 364 0 None None Mitogen-activated protein kinase 8
4AWIA 1.91 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_oooo AQ2 Type1 8 - 364 0 None None Mitogen-activated protein kinase 8
5LW1B 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
5LW1E 3.2 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
5LW1H 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8
4QTDA 1.5 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo 38Z, ANP Type1, Allosteric 6 - 363 0 None None Mitogen-activated protein kinase 8
9FT9A 2.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 7 - 363 0 None None Mitogen-activated protein kinase 8
3V3VA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii MYU Type1 7 - 363 0 None None Mitogen-activated protein kinase 8
2GMXA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 877 Type1 8 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
4UX9B 2.34 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 362 0 None None Mitogen-activated protein kinase 8
2G01B 3.5 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 73Q Type1 9 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
2GMXB 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 877 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8
3VULA 2.81 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 7 - 364 0 None C79V,C116S,C137V,C163A,C213V,C245S Mitogen-activated protein kinase 8
3VUMA 2.69 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 7 - 364 0 None C41V,C79V,C116S,C137V,C163A,C213V,C245S Mitogen-activated protein kinase 8

CMGC_MAPK8 (Mitogen-activated protein kinase 8)

Total number of chains: 62
Active chains: 16
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 38 61.3% 8R5EA
DFGin BLAminus 21 33.9% AF-P45983-K1A
DFGin None 3 4.8% 2G01B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MK08_HUMAN 3O2MA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3O2MB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 46A Allosteric 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VUIA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C79V,C116S,C163A,C245S Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VUHA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C116S,C163A,C245S Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VUDA 3.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C245S Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VUGA 3.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C116S,C245S Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VUKA 2.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 364 0 None C79V,C116S,C137V,C163A,C245S Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN AF-P45983-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 329 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN AF-P45983-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 18 - 329 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3O17A 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 363 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3O17B 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 363 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2G01A 3.5 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii 73Q Type1 10 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2H96A 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 893 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2H96B 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 893 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2NO3A 3.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 859 Type1 8 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2NO3B 3.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 859 Type1 7 - 363 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 6ZR5A 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 3 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 6ZR5B 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 4 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2XRWA 1.33 Inactive DFGin‑ABAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 364 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2XS0A 2.6 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ANP ATPlike 6 - 365 0 None T183V,Y185F Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4UX9A 2.34 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4UX9C 2.34 Inactive DFGin‑ABAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4UX9D 2.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_oioo ANP ATPlike 9 - 364 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8R5EA 1.7 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP, Y6K ATPlike, Allosteric 5 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 1UKHA 2.35 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 9 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4YR8A 2.4 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4YR8C 2.4 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 10 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4YR8E 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 7 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4YR8F 2.4 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 10 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 6F5EB 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 7 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8X5MA 2.0 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno Y4O Type1 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PT8A 2.78 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nioo A3O Type1 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PT8B 2.78 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaooi APEdist_iioo A3O Type1 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PT8C 2.78 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo A3O Type1 7 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PT9A 2.7 Inactive DFGin‑ABAminus out-in out-out nonTYR APEdihe_aaooi APEdist_iooo DVI Type1 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PT9B 2.7 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aaioi APEdist_nioo DVI Type1 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PT9C 2.7 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo DVI Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PTAA 2.41 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iooo CIF Type1 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PTAB 2.41 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo CIF Type1 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 8PTAC 2.41 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo CIF Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 1UKIA 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanio APEdist_nnnn 537 Type1 9 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4E73A 2.27 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 0NR Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4G1WA 2.45 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn G1W Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4HYSA 2.415 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1BJ Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4HYUA 2.152 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1BK Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4IZYA 2.3 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1J2 Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3PZEA 2.0 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno CFK Type1 7 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4L7FA 1.95 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnoo 1V5 Type1 7 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3ELJA 1.8 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_oooo GS7 Type1 7 - 364 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4AWIA 1.91 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaiii APEdist_oooo AQ2 Type1 8 - 364 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 5LW1B 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 5LW1E 3.2 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 5LW1H 3.2 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ADN Type1 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4QTDA 1.5 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo 38Z, ANP Type1, Allosteric 6 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 9FT9A 2.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3V3VA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii MYU Type1 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2GMXA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 877 Type1 8 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 4UX9B 2.34 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2G01B 3.5 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 73Q Type1 9 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 2GMXB 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 877 Type1 7 - 364 0 None T183E,Y185E Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VULA 2.81 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 7 - 364 0 None C79V,C116S,C137V,C163A,C213V,C245S Mitogen-activated protein kinase 8 Homo sapiens
MK08_HUMAN 3VUMA 2.69 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 7 - 364 0 None C41V,C79V,C116S,C137V,C163A,C213V,C245S Mitogen-activated protein kinase 8 Homo sapiens

CMGC_MAPK8 (Mitogen-activated protein kinase 8)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism