8PT8

MAPK8 (Mitogen-activated protein kinase 8)
Group: CMGC
Uniprot: MK08_HUMAN
Organism: Homo sapiens
Domain boundary: 26 - 321
Resolu: 2.78

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-out in-out A3O Type1 7 - 363 2
B Inactive DFGin ABAminus out-out out-out A3O Type1 8 - 363 0
C Inactive DFGin ABAminus in-out out-out A3O Type1 7 - 362 3
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain C
         8         18         28         38 
gsmsrskrDN NFYSVEIGDS TFTVLKRYQN LKPIGSGAQG 
        48         58         68         78 
IVCAAYDAIL ERNVAIKKLS RPFQNQTHAK RAYRELVLMK 
        88         98        108        118 
CVNHKNIIGL LNVFTPQKSL EEFQDVYIVM ELMDANLCQV 
       128        138        148        158 
IQMELDHERM SYLLYQMLCG IKHLHSAGII HRDLKPSNIV 
       168        178        188        198 
VKSDCTLKIL DFGLARTAGT SFMMtpyVVT RYYRAPEVIL 
       208        218        228        238 
GMGYKENVDI WSVGCIMGEM IKGGVLFPGT DHIDQWNKVI 
       248        258        268        278 
EQLGTPCPEF MKKLQPTVRT YVENRPKYAG YSFEKLFPDV 
       288        298        308        318 
LFPADSEHNK LKASQARDLL SKMLVIDASK RISVDEALQH 
       328        338        348        358 
PYINVWYDPS EAEAPPPKIP DKQLDEREHT IEEWKELIYK 

EVMDle
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None