CMGC_MAPK8 (Mitogen-activated protein kinase 8)

Total number of chains: 62
Active chains: 16
Family: CMGC
Uniprot: MK08_HUMAN
Kinase Domain Residues: 26 - 321
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 38 61.3% 8R5EA
DFGin BLAminus 21 33.9% AF-P45983-K1A
DFGin None 3 4.8% 2G01B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
3O2MA 7 364 427.0 46A:60701 Allosteric Active DFGin 6.41 14.267 BLAminus -152.63, 162.08 80.49, 93.8 -114.77, 18.61 304.8, 107.67 -61.69, -39.94 in-in in 8.742 Saltbr-in 2.619 HRD-in -69.47, -52.78 72.9, -13.97 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.53, -31.31 APE9-dihe-na -91.45, 126.81 APE8-dihe-in -59.5, 135.65 APE8-rot-in 301.85 APE67-dihe-in -63.02, -13.15 -75.49, -27.8 APE12-dist-in 11.207 APE11-dist-in 12.783 APE10-dist-in 7.434 APE9-dist-in 5.528 T183E,Y185E None None XRAY 2.7 0.233 0.266 A 370 358 0 0 0 0 [[26, 321]] 1.0 3o2m CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3O2MB 7 364 427.0 46A:60701 Allosteric Active DFGin 6.433 14.024 BLAminus -142.38, 178.22 61.31, 93.12 -105.38, 24.63 305.62, 107.49 -54.81, -31.65 in-in in 9.059 Saltbr-in 2.7 HRD-in -67.22, -47.31 66.21, -6.68 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -49.13, -35.19 APE9-dihe-na -86.25, 135.93 APE8-dihe-in -71.9, 130.6 APE8-rot-in 296.5 APE67-dihe-in -57.01, -19.27 -49.25, -52.93 APE12-dist-in 11.564 APE11-dist-in 12.879 APE10-dist-in 7.96 APE9-dist-in 5.541 T183E,Y185E None None XRAY 2.7 0.233 0.266 B 370 358 0 0 0 0 [[26, 321]] 1.0 3o2m CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VUIA 7 364 427.0 No_ligand No_ligand Active DFGin 6.279 13.637 BLAminus -161.71, 166.24 49.14, 98.79 -100.93, 7.58 304.49, 111.2 -57.41, -21.38 in-in in 8.445 Saltbr-in 2.751 HRD-in -80.72, -34.44 66.81, -22.35 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.67, -34.53 APE9-dihe-na -81.58, 139.5 APE8-dihe-in -52.39, 128.3 APE8-rot-in 307.22 APE67-dihe-in -66.42, -12.33 -38.87, -57.39 APE12-dist-in 13.587 APE11-dist-in 13.146 APE10-dist-in 7.295 APE9-dist-in 4.59 C79V,C116S,C163A,C245S None None XRAY 2.8 0.22 0.282 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vui CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.7 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VUHA 7 364 427.0 No_ligand No_ligand Active DFGin 6.245 13.536 BLAminus -148.39, 170.84 44.38, 107.19 -110.71, 10.86 305.1, 110.58 -49.1, -34.53 in-in in 8.346 Saltbr-in 2.814 HRD-in -67.84, -45.56 77.42, -28.42 in-in-in SNCiii in-in ActLoopNT-in 2.684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.33, -19.09 APE9-dihe-na -84.3, 142.26 APE8-dihe-in -58.96, 126.9 APE8-rot-in 301.88 APE67-dihe-in -66.35, -10.47 -35.08, -59.67 APE12-dist-in 13.31 APE11-dist-in 12.859 APE10-dist-in 7.142 APE9-dist-in 4.924 C116S,C163A,C245S None None XRAY 2.7 0.197 0.256 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vuh CMGC_MAPK8_HUMAN CMGC 3e-84 288.7 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VUDA 7 364 427.0 No_ligand No_ligand Active DFGin 6.321 13.192 BLAminus -128.97, 166.57 47.01, 116.8 -121.87, 36.87 302.27, 89.43 -73.6, -27.82 in-in in 8.32 Saltbr-in 2.706 HRD-in -64.61, -34.78 67.2, -26.38 in-in-in SNCiii in-in ActLoopNT-in 2.483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.25, -55.44 APE9-dihe-na -80.77, 154.38 APE8-dihe-in -65.03, 131.96 APE8-rot-in 311.85 APE67-dihe-in -68.72, -34.8 -46.83, -54.0 APE12-dist-in 13.351 APE11-dist-in 12.875 APE10-dist-in 6.82 APE9-dist-in 4.983 C245S None None XRAY 3.5 0.204 0.293 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vud CMGC_MAPK8_HUMAN CMGC 5.6e-85 291.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VUGA 7 364 427.0 No_ligand No_ligand Active DFGin 6.241 13.67 BLAminus -151.25, 155.67 63.84, 102.6 -110.8, 4.88 299.0, 108.74 -61.2, -37.22 in-in in 8.464 Saltbr-in 2.615 HRD-in -84.82, -38.91 70.88, -35.15 in-in-in SNCiii in-in ActLoopNT-in 2.628 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.41, -25.55 APE9-dihe-na -88.01, 136.95 APE8-dihe-in -41.17, 111.55 APE8-rot-in 298.57 APE67-dihe-in -72.82, -30.6 -28.21, -48.81 APE12-dist-in 13.411 APE11-dist-in 12.868 APE10-dist-in 7.045 APE9-dist-in 4.813 C116S,C245S None None XRAY 3.24 0.195 0.284 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vug CMGC_MAPK8_HUMAN CMGC 1.1e-84 290.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VUKA 7 364 427.0 No_ligand No_ligand Active DFGin 5.846 13.336 BLAminus -160.02, 162.58 68.67, 104.55 -110.92, -0.02 303.39, 88.83 -56.44, -11.87 in-in in 8.098 Saltbr-in 2.754 HRD-in -73.52, -45.64 80.08, -26.39 in-in-in SNCiii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.92, -26.67 APE9-dihe-na -92.92, 137.67 APE8-dihe-in -49.6, 127.14 APE8-rot-in 331.83 APE67-dihe-in -67.5, -4.18 -38.21, -62.31 APE12-dist-in 13.399 APE11-dist-in 12.898 APE10-dist-in 7.131 APE9-dist-in 4.942 C79V,C116S,C137V,C163A,C245S None None XRAY 2.95 0.229 0.302 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vuk CMGC_MAPK8_HUMAN CMGC 4.2e-83 285.0 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
AF-P45983-K1A 18 329 427.0 No_ligand No_ligand Active DFGin 6.415 13.643 BLAminus -143.36, 178.91 71.76, 59.86 -79.25, 6.67 305.71, 110.21 -57.24, -28.48 in-in in 8.761 Saltbr-in 2.704 HRD-in -68.06, -45.26 66.86, -8.1 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.62, -32.38 APE9-dihe-na -74.54, 148.67 APE8-dihe-in -64.82, 122.89 APE8-rot-in 305.16 APE67-dihe-in -66.57, -21.46 -45.8, -48.81 APE12-dist-in 12.864 APE11-dist-in 12.524 APE10-dist-in 6.814 APE9-dist-in 4.407 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[26, 321]] 1.0 AF-P45983-K1 CMGC_MAPK8_HUMAN CMGC 2.4e-84 288.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
AF-P45983-K3A 18 329 427.0 No_ligand No_ligand Active DFGin 6.101 14.421 BLAminus -131.11, 176.97 65.27, 65.06 -73.24, 10.87 295.36, 94.81 -61.15, -20.86 in-in in 9.583 Saltbr-in 2.736 HRD-in -74.19, -48.13 61.63, 17.91 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.5, 167.97 APE9-dihe-na 65.01, 133.8 APE8-dihe-in -55.56, 132.77 APE8-rot-in 297.67 APE67-dihe-in -67.94, -21.16 -47.15, -46.41 APE12-dist-in 12.774 APE11-dist-in 11.096 APE10-dist-in 6.429 APE9-dist-in 3.166 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[26, 321]] 1.0 AF-P45983-K3 CMGC_MAPK8_HUMAN CMGC 2.4e-84 288.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3O17A 7 363 427.0 No_ligand No_ligand Active DFGin 6.128 13.992 BLAminus -143.08, -155.15 4.86, 119.05 -115.61, 15.13 291.48, 95.12 -55.48, -42.85 in-in in 8.925 Saltbr-in 2.977 HRD-in -88.38, -43.35 58.03, 10.08 in-in-in SNCiii in-in ActLoopNT-in 2.373 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.55, -54.88 APE9-dihe-na -56.03, 107.98 APE8-dihe-in -41.53, 122.11 APE8-rot-in 303.39 APE67-dihe-in -26.7, -32.66 -31.75, -85.44 APE12-dist-in 10.596 APE11-dist-in 11.643 APE10-dist-in 6.843 APE9-dist-in 4.565 T183E,Y185E None None XRAY 3.0 0.263 0.308 A 370 357 0 0 0 0 [[26, 321]] 1.0 3o17 CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3O17B 7 363 427.0 No_ligand No_ligand Active DFGin 6.377 13.354 BLAminus -141.52, 176.46 56.9, 126.68 -136.61, 6.27 299.25, 120.4 -50.46, -23.38 in-in in 9.214 Saltbr-in 3.093 HRD-in -88.24, -52.87 72.9, -9.22 in-in-in SNCiii in-in ActLoopNT-in 2.494 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -59.17, -32.26 APE9-dihe-na -88.08, 142.34 APE8-dihe-in -62.23, 117.26 APE8-rot-in 321.66 APE67-dihe-in -47.49, -37.82 -30.24, -67.12 APE12-dist-in 11.738 APE11-dist-in 12.434 APE10-dist-in 7.042 APE9-dist-in 4.542 T183E,Y185E None None XRAY 3.0 0.263 0.308 B 370 357 0 0 0 0 [[26, 321]] 1.0 3o17 CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2G01A 10 364 427.0 73Q:60901 Type1 Active DFGin 5.994 14.611 BLAminus -138.21, 160.8 78.02, 123.65 -129.29, 5.43 293.89, 44.0 -38.65, -23.81 out-in out 10.378 Saltbr-in 3.558 HRD-in -86.8, -31.67 38.11, 34.11 in-in-in SNCiii in-in ActLoopNT-in 2.657 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.24, -50.25 APE9-dihe-na -79.72, 72.99 APE8-dihe-in -7.98, 107.48 APE8-rot-in 347.58 APE67-dihe-in -48.8, -23.78 -62.13, -32.37 APE12-dist-in 12.169 APE11-dist-in 12.925 APE10-dist-in 7.597 APE9-dist-in 4.571 T183E,Y185E None None XRAY 3.5 0.296 0.354 A 370 355 0 0 0 0 [[26, 321]] 1.0 2g01 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2H96A 7 364 427.0 893:60901 Type1 Active DFGin 5.747 14.071 BLAminus -142.02, 170.57 47.6, 140.71 -141.49, -1.15 291.84, 115.53 -55.85, -8.38 in-in in 9.102 Saltbr-in 2.822 HRD-in -85.69, -41.32 64.83, 4.35 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.81, -40.52 APE9-dihe-na -68.31, 154.87 APE8-dihe-in -75.38, 102.01 APE8-rot-in 313.08 APE67-dihe-in -53.52, -10.26 -11.43, -68.01 APE12-dist-in 11.968 APE11-dist-in 12.521 APE10-dist-in 7.041 APE9-dist-in 4.451 T183E,Y185E None None XRAY 3.0 0.243 0.278 A 370 358 0 0 0 0 [[26, 321]] 1.0 2h96 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2H96B 7 364 427.0 893:60902 Type1 Active DFGin 5.807 14.068 BLAminus -144.72, 174.09 54.02, 123.29 -119.24, -14.41 278.05, 179.66 -39.96, -62.74 in-in in 9.069 Saltbr-in 2.973 HRD-in -74.32, -61.93 80.7, -10.76 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.3, -36.87 APE9-dihe-na -83.37, 136.31 APE8-dihe-in -75.86, 124.1 APE8-rot-in 311.58 APE67-dihe-in -48.77, -30.54 -42.37, -58.0 APE12-dist-in 11.862 APE11-dist-in 12.758 APE10-dist-in 7.201 APE9-dist-in 5.246 T183E,Y185E None None XRAY 3.0 0.243 0.278 B 370 358 0 0 0 0 [[26, 321]] 1.0 2h96 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2NO3A 8 364 427.0 859:901 Type1 Active DFGin 5.863 13.89 BLAminus -141.07, 148.97 75.82, 137.69 -138.71, 16.78 294.85, 98.43 -54.01, -64.02 in-in in 8.481 Saltbr-in 2.792 HRD-in -92.56, -31.18 61.32, -24.16 in-in-in SNCiii in-in ActLoopNT-in 2.551 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -47.4, -34.85 APE9-dihe-na -77.56, 142.56 APE8-dihe-in -59.37, 120.51 APE8-rot-in 310.95 APE67-dihe-in -29.44, -22.2 -32.85, -87.31 APE12-dist-in 11.933 APE11-dist-in 12.043 APE10-dist-in 6.66 APE9-dist-in 4.818 T183E,Y185E None None XRAY 3.2 0.233 0.276 A 370 357 0 0 0 0 [[26, 321]] 1.0 2no3 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2NO3B 7 363 427.0 859:902 Type1 Active DFGin 6.499 14.159 BLAminus -157.78, 177.02 69.64, 114.69 -132.65, 1.82 296.08, 106.12 -53.25, -7.72 in-in in 9.161 Saltbr-in 3.0 HRD-in -57.79, -52.24 74.94, -7.51 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.63, -57.06 APE9-dihe-na -57.37, 144.61 APE8-dihe-in -64.67, 111.29 APE8-rot-in 358.49 APE67-dihe-in -34.54, -28.75 -26.01, -79.7 APE12-dist-in 12.833 APE11-dist-in 13.376 APE10-dist-in 7.543 APE9-dist-in 4.807 T183E,Y185E None None XRAY 3.2 0.233 0.276 B 370 357 0 0 0 0 [[26, 321]] 1.0 2no3 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
6ZR5A 3 362 427.0 ANP:60402 ATPlike Inactive DFGin 3.817 14.226 ABAminus -84.03, -42.55 -114.88, 174.79 -114.82, 8.54 299.13, 101.86 79.5, -168.62 out-out out 10.002 Saltbr-out 5.031 HRD-in -56.29, -55.44 70.4, -2.27 out-out-out SNCooo out-out ActLoopNT-out 6.872 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.14 APE8-rot-out 87.08 APE67-dihe-in -67.28, -21.26 -101.91, 26.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.699 0.186 0.256 A 366 348 12 0 0 12 [[26, 321]] 1.0 6zr5 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
6ZR5B 4 362 427.0 ANP:60400 ATPlike Inactive DFGin 3.867 14.072 ABAminus -85.51, -41.13 -110.19, 172.79 -115.96, 8.05 294.61, 92.39 79.48, -170.78 out-out out 10.021 Saltbr-out 4.224 HRD-in -59.93, -50.9 67.15, -3.15 out-out-out SNCooo out-out ActLoopNT-out 6.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -100.6, 89.98 APE9-dihe-na -140.16, 151.66 APE8-dihe-in -87.57, 109.71 APE8-rot-in 298.46 APE67-dihe-in -73.45, -13.54 -100.12, 16.22 APE12-dist-out 17.551 APE11-dist-in 12.898 APE10-dist-out 16.341 APE9-dist-out 11.496 None None None XRAY 2.699 0.186 0.256 B 366 359 0 0 0 0 [[26, 321]] 1.0 6zr5 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2XRWA 2 364 427.0 ANP:61367 ATPlike Inactive DFGin 3.816 13.941 ABAminus -85.3, -24.5 -153.59, -177.02 -115.68, 7.02 304.14, 97.05 88.01, -156.78 in-out in 9.886 Saltbr-out 4.635 HRD-in -83.3, -58.4 77.36, -14.29 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.45, -23.57 999.0, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.33 0.166 0.187 A 371 347 16 0 0 16 [[26, 321]] 1.0 2xrw CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2XS0A 6 365 427.0 ANP:1367 ATPlike Inactive DFGin 3.754 14.081 ABAminus -75.25, -22.88 -148.14, -178.22 -116.01, 26.92 303.04, 86.85 61.81, -161.42 in-out in 9.735 Saltbr-out 5.55 HRD-in -69.33, -60.51 78.49, -20.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.45 APE8-rot-out 188.87 APE67-dihe-out -73.26, -26.46 -135.55, 95.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T183V,Y185F None None XRAY 2.6 0.194 0.246 A 386 346 14 0 0 14 [[26, 321]] 1.0 2xs0 CMGC_MAPK8_HUMAN CMGC 4.5e-83 284.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4UX9A 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.508 13.598 ABAminus -106.9, -65.56 -75.5, 125.74 -123.36, 16.47 304.33, 124.23 -68.62, -34.25 in-out in 8.85 Saltbr-out 3.673 HRD-in -62.88, -46.37 73.76, -28.18 out-in-in SNCoii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.3, -23.46 APE9-dihe-na -71.58, 140.2 APE8-dihe-in -64.86, 127.48 APE8-rot-in 308.5 APE67-dihe-in -60.43, -26.76 -33.69, -61.49 APE12-dist-in 11.784 APE11-dist-in 12.426 APE10-dist-in 6.631 APE9-dist-in 4.533 None None None XRAY 2.34 0.202 0.24 A 364 343 7 0 0 5 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4UX9C 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.956 13.776 ABAminus -110.49, -64.95 -89.1, 120.63 -119.14, 21.23 309.02, 115.06 -68.23, -26.49 in-out in 8.919 Saltbr-out 3.636 HRD-in -66.22, -47.15 71.23, -16.82 out-in-none SNCoin in-none ActLoopNT-in 2.569 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -79.69, -26.4 APE9-dihe-na -76.07, 142.18 APE8-dihe-in -66.37, 127.01 APE8-rot-in 305.02 APE67-dihe-in -64.57, -24.76 -35.27, -55.26 APE12-dist-none 999.0 APE11-dist-in 12.005 APE10-dist-in 6.53 APE9-dist-in 4.621 None None None XRAY 2.34 0.202 0.24 C 364 333 15 0 0 7 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4UX9D 9 364 427.0 ANP:1000 ATPlike Inactive DFGin 6.755 13.406 ABAminus -120.6, -55.98 -93.07, 108.1 -98.68, 25.97 301.07, 117.04 -64.8, -33.9 in-in in 9.366 Saltbr-in 2.738 HRD-in -59.8, -49.61 70.57, -12.64 in-in-out SNCiio in-out ActLoopNT-in 2.67 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -95.31, 105.19 APE9-dihe-na -74.34, -56.46 APE8-dihe-in -76.71, 134.72 APE8-rot-out 95.68 APE67-dihe-out -66.63, -26.9 -139.86, 50.27 APE12-dist-out 14.031 APE11-dist-in 13.438 APE10-dist-out 10.823 APE9-dist-out 13.555 None None None XRAY 2.34 0.202 0.24 D 364 344 9 0 0 0 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8R5EA 5 363 427.0 ANP:402,Y6K:403 ATPlike,Allosteric Inactive DFGin 4.215 13.884 ABAminus -92.07, -26.65 -133.67, 178.16 -123.93, 6.5 294.94, 97.33 89.15, -162.77 in-out in 9.521 Saltbr-out 4.842 HRD-in -77.17, -59.97 76.05, -10.25 out-out-out SNCooo out-out ActLoopNT-out 6.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.14, 143.17 APE9-dihe-na -120.32, 118.65 APE8-dihe-in -75.39, 123.94 APE8-rot-in 299.29 APE67-dihe-in -61.41, -23.9 -115.12, 4.11 APE12-dist-out 18.707 APE11-dist-out 15.325 APE10-dist-out 16.68 APE9-dist-out 11.244 None None None XRAY 1.7 0.177 0.222 A 366 359 0 0 0 0 [[26, 321]] 1.0 8r5e CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
1UKHA 9 363 427.0 No_ligand No_ligand Inactive DFGin 4.009 13.592 ABAminus -71.05, -50.54 -134.57, 170.42 -88.05, 19.73 310.31, 96.24 54.55, -119.32 in-in in 8.726 Saltbr-in 3.539 HRD-in -32.35, -66.36 74.83, -11.73 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -21.95 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.229 0.245 A 369 321 22 0 0 17 [[26, 321]] 1.0 1ukh CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4YR8A 8 362 427.0 No_ligand No_ligand Inactive DFGin 3.746 13.651 ABAminus -92.48, -36.82 -128.7, -177.95 -116.24, 9.95 302.59, 109.3 79.22, -159.79 in-in in 9.397 Saltbr-in 2.717 HRD-in -91.12, -57.47 70.8, -11.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.35 APE8-dihe-in -90.35, 105.5 APE8-rot-out 50.94 APE67-dihe-in -67.62, -16.88 -108.83, 0.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.175 None None None XRAY 2.4 0.218 0.239 A 371 320 17 0 0 13 [[26, 321]] 1.0 4yr8 CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4YR8C 10 362 427.0 No_ligand No_ligand Inactive DFGin 4.345 13.391 ABAminus -88.52, -41.45 -131.53, -175.1 -114.96, 11.59 302.69, 109.92 79.73, 999.0 in-in in 8.874 Saltbr-in 2.694 HRD-in -68.29, -62.18 77.05, -0.67 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.23 APE8-rot-none 999.0 APE67-dihe-in -64.66, -18.42 -99.29, -2.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.218 0.239 C 371 318 21 0 0 16 [[26, 321]] 1.0 4yr8 CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4YR8E 7 362 427.0 No_ligand No_ligand Inactive DFGin 3.728 14.137 ABAminus -86.08, -36.9 -129.28, 170.42 -104.47, 7.33 299.61, 110.26 81.64, -165.5 out-out out 10.093 Saltbr-out 3.695 HRD-in -78.61, -55.83 65.3, 1.9 out-out-out SNCooo out-out ActLoopNT-out 6.891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -50.39 APE8-dihe-in -79.39, 102.65 APE8-rot-out 53.21 APE67-dihe-in -61.82, -18.77 -109.31, -0.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.794 None None None XRAY 2.4 0.218 0.239 E 371 317 17 0 0 12 [[26, 321]] 1.0 4yr8 CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4YR8F 10 362 427.0 No_ligand No_ligand Inactive DFGin 4.607 13.334 ABAminus -92.28, -40.63 -125.1, 178.19 -117.35, 11.6 304.63, 110.41 81.03, 999.0 in-in in 8.547 Saltbr-in 2.414 HRD-in -61.32, -58.08 77.0, -3.6 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 114.52 APE8-rot-none 999.0 APE67-dihe-in -64.79, -18.18 -101.48, -2.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.218 0.239 F 371 300 38 0 0 16 [[26, 321]] 1.0 4yr8 CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
6F5EB 7 362 427.0 No_ligand No_ligand Inactive DFGin 4.245 14.401 ABAminus -85.23, -40.02 -143.49, -172.1 -102.9, -4.9 292.34, 110.9 97.56, -150.23 in-in in 9.252 Saltbr-in 3.161 HRD-in -56.05, -56.91 72.46, 7.42 in-out-out SNCioo out-out ActLoopNT-out 7.913 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.0 APE9-dihe-na -95.81, 149.23 APE8-dihe-out -71.37, -38.95 APE8-rot-in 293.49 APE67-dihe-in -53.11, -31.53 -58.04, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.756 APE9-dist-out 11.174 None None None XRAY 2.7 0.202 0.226 B 373 346 10 0 0 4 [[26, 321]] 1.0 6f5e CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8X5MA 7 363 427.0 Y4O:401 Type1 Inactive DFGin 3.829 13.721 ABAminus -82.03, -35.59 -145.84, 177.75 -109.61, 10.51 302.7, 100.16 80.95, -155.06 in-in in 9.106 Saltbr-in 2.768 HRD-in -69.78, -60.93 77.08, -7.13 in-out-out SNCioo out-out ActLoopNT-out 7.237 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.93 APE8-dihe-in -94.27, 100.92 APE8-rot-in 297.8 APE67-dihe-in -57.39, -30.56 -110.37, 11.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.16 None None CSO163 XRAY 2.0 0.195 0.234 A 363 341 16 0 0 12 [[26, 321]] 1.0 8x5m CMGC_MAPK8_HUMAN CMGC 7.9e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PT8A 7 363 427.0 A3O:401 Type1 Inactive DFGin 3.511 13.641 ABAminus -86.46, -36.69 -113.24, 157.51 -107.14, 5.23 297.22, 84.35 63.56, -136.9 in-out in 9.722 Saltbr-out 5.472 HRD-in -69.36, -62.04 67.14, -1.26 out-in-out SNCoio in-out ActLoopNT-in 3.259 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -78.69, 132.14 APE9-dihe-na -97.09, 6.93 APE8-dihe-in -119.44, 125.16 APE8-rot-out 77.92 APE67-dihe-in -61.62, -35.67 -102.35, -19.0 APE12-dist-none 999.0 APE11-dist-in 10.056 APE10-dist-out 10.166 APE9-dist-out 11.407 None None None XRAY 2.78 0.219 0.218 A 366 353 2 0 0 2 [[26, 321]] 1.0 8pt8 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PT8B 8 363 427.0 A3O:401 Type1 Inactive DFGin 3.708 13.56 ABAminus -87.46, -36.99 -114.07, 158.6 -107.2, 3.96 306.69, 95.61 61.75, -138.76 out-out out 10.014 Saltbr-out 4.707 HRD-in -65.17, -60.14 69.69, -8.9 out-out-out SNCooo out-out ActLoopNT-out 5.034 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -125.68, 169.43 APE9-dihe-na -89.29, -51.47 APE8-dihe-out 50.18, 54.05 APE8-rot-out 80.12 APE67-dihe-in -59.08, -31.41 -75.35, -27.98 APE12-dist-in 11.342 APE11-dist-in 8.524 APE10-dist-out 11.671 APE9-dist-out 8.634 None None None XRAY 2.78 0.219 0.218 B 366 354 0 0 0 0 [[26, 321]] 1.0 8pt8 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PT8C 7 362 427.0 A3O:401 Type1 Inactive DFGin 4.333 13.634 ABAminus -100.64, -42.98 -112.04, 163.18 -107.79, 3.91 318.61, 83.5 62.89, -142.35 in-out in 9.361 Saltbr-out 6.354 HRD-in -65.16, -58.91 71.32, -6.19 out-out-out SNCooo out-out ActLoopNT-out 5.135 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -0.16 APE9-dihe-na -89.45, -4.71 APE8-dihe-in -89.37, 113.03 APE8-rot-out 66.41 APE67-dihe-in -51.88, -31.5 -134.08, -10.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.551 APE9-dist-out 11.436 None None None XRAY 2.78 0.219 0.218 C 366 353 3 0 0 3 [[26, 321]] 1.0 8pt8 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PT9A 8 363 427.0 DVI:401 Type1 Inactive DFGin 3.672 13.845 ABAminus -82.42, -42.96 -101.44, 156.25 -107.65, 10.42 293.61, 64.96 107.26, -173.51 out-in out 10.218 Saltbr-in 3.165 HRD-in -86.93, -57.09 73.38, 1.77 in-out-out SNCioo out-out ActLoopNT-out 6.35 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -132.39, 130.51 APE9-dihe-na -63.89, -49.36 APE8-dihe-out 47.93, 60.73 APE8-rot-out 86.13 APE67-dihe-in -60.85, -39.95 -75.12, -7.36 APE12-dist-in 10.069 APE11-dist-out 6.914 APE10-dist-out 10.64 APE9-dist-out 8.438 None None None XRAY 2.7 0.215 0.225 A 366 353 2 0 0 2 [[26, 321]] 1.0 8pt9 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PT9B 7 363 427.0 DVI:401 Type1 Inactive DFGin 3.602 13.359 ABAminus -78.87, -38.7 -110.84, 150.53 -102.26, 4.03 302.35, 93.73 66.71, -148.92 in-out in 9.405 Saltbr-out 4.004 HRD-in -82.54, -61.31 64.36, 5.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -99.2, 123.92 APE9-dihe-na -85.67, -7.28 APE8-dihe-in -87.66, 94.6 APE8-rot-out 69.53 APE67-dihe-in -57.65, -34.34 -84.42, -14.13 APE12-dist-none 999.0 APE11-dist-in 9.964 APE10-dist-out 10.65 APE9-dist-out 11.067 None None None XRAY 2.7 0.215 0.225 B 366 351 5 0 0 5 [[26, 321]] 1.0 8pt9 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PT9C 8 362 427.0 DVI:401 Type1 Inactive DFGin 3.804 14.256 ABAminus -88.85, -34.33 -106.1, 147.38 -98.39, 6.8 298.91, 67.63 59.14, -132.88 out-out out 10.183 Saltbr-out 3.89 HRD-in -79.93, -61.89 65.26, 3.23 out-out-out SNCooo out-out ActLoopNT-out 4.679 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.35 APE9-dihe-na -94.15, 7.09 APE8-dihe-in -84.28, 82.63 APE8-rot-out 73.62 APE67-dihe-in -62.72, -39.65 -92.57, -5.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.934 APE9-dist-out 11.223 None None None XRAY 2.7 0.215 0.225 C 366 352 3 0 0 3 [[26, 321]] 1.0 8pt9 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PTAA 8 363 427.0 CIF:401 Type1 Inactive DFGin 3.923 14.477 ABAminus -80.58, -61.37 -103.85, 165.38 -100.79, 23.99 295.77, 91.74 73.84, -149.47 in-in in 9.79 Saltbr-in 3.126 HRD-in -78.59, -61.53 62.23, 7.12 in-out-out SNCioo out-out ActLoopNT-out 6.47 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -130.45, 138.38 APE9-dihe-na -101.99, 109.25 APE8-dihe-in -118.89, 112.23 APE8-rot-out 53.5 APE67-dihe-in -51.79, -30.07 -95.29, -17.54 APE12-dist-in 10.569 APE11-dist-out 7.033 APE10-dist-out 10.183 APE9-dist-out 8.598 None None None XRAY 2.41 0.224 0.226 A 366 354 2 0 0 2 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PTAB 7 363 427.0 CIF:401 Type1 Inactive DFGin 3.577 13.179 ABAminus -81.24, -57.35 -101.3, 158.61 -105.36, 14.2 308.93, 93.28 64.59, -148.13 in-in in 9.366 Saltbr-in 3.536 HRD-in -77.41, -61.25 61.49, 9.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.33, 168.25 APE9-dihe-na -116.9, 36.67 APE8-dihe-in -104.63, 91.0 APE8-rot-out 52.55 APE67-dihe-in -56.88, -29.41 -95.02, -21.65 APE12-dist-in 11.784 APE11-dist-in 9.152 APE10-dist-out 11.242 APE9-dist-out 10.214 None None None XRAY 2.41 0.224 0.226 B 366 352 5 0 0 5 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
8PTAC 8 361 427.0 CIF:401 Type1 Inactive DFGin 3.826 14.088 ABAminus -83.97, -56.35 -97.04, 154.46 -105.76, 13.83 294.99, 32.04 63.79, -147.27 in-out in 9.723 Saltbr-out 4.528 HRD-in -77.01, -60.9 63.25, 7.56 out-out-out SNCooo out-out ActLoopNT-out 4.611 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -137.59 APE9-dihe-na -94.11, 17.64 APE8-dihe-in -81.48, 63.35 APE8-rot-out 71.39 APE67-dihe-in -58.68, -26.77 -108.19, -24.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.467 APE9-dist-out 10.78 None None None XRAY 2.41 0.224 0.226 C 366 351 3 0 0 3 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
1UKIA 9 363 427.0 537:0 Type1 Inactive DFGin 4.704 13.114 ABAminus -77.11, -62.2 -116.68, -161.07 -126.7, 15.2 318.68, 71.9 41.91, -116.91 in-in in 9.169 Saltbr-in 2.916 HRD-in -66.76, -57.64 78.15, -46.3 in-out-out SNCioo out-out ActLoopNT-out 5.456 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.25 APE8-rot-in 304.87 APE67-dihe-out -76.75, -17.12 155.56, -17.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.221 0.241 A 369 328 18 0 0 13 [[26, 321]] 1.0 1uki CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4E73A 8 361 427.0 0NR:60401 Type1 Inactive DFGin 3.941 13.714 ABAminus -80.5, -42.58 -144.32, -163.84 -110.6, 6.62 304.02, 132.42 68.66, -151.79 in-in in 9.116 Saltbr-in 2.603 HRD-in -76.2, -63.12 71.21, -5.48 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.49, -32.11 999.0, 34.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.249 0.282 A 369 318 23 0 0 15 [[26, 321]] 1.0 4e73 CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4G1WA 8 361 427.0 G1W:60401 Type1 Inactive DFGin 4.13 13.747 ABAminus -75.19, -46.06 -145.01, -166.31 -101.8, 11.35 310.93, 129.6 54.15, -150.73 in-in in 9.512 Saltbr-in 2.815 HRD-in -74.24, -60.52 76.29, -17.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.92 APE8-rot-in 305.3 APE67-dihe-in -68.41, -20.62 -111.33, 3.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.233 0.297 A 369 322 22 0 0 15 [[26, 321]] 1.0 4g1w CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4HYSA 8 361 427.0 1BJ:60401 Type1 Inactive DFGin 4.144 13.704 ABAminus -65.58, -42.99 -148.13, -172.29 -105.42, 11.47 305.84, 116.47 62.72, -152.88 in-in in 9.169 Saltbr-in 2.542 HRD-in -81.1, -55.52 80.05, -13.7 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 85.27 APE8-rot-in 300.61 APE67-dihe-in -75.95, -19.65 -89.11, 15.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.415 0.249 0.295 A 369 321 23 0 0 15 [[26, 321]] 1.0 4hys CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4HYUA 8 361 427.0 1BK:60401 Type1 Inactive DFGin 4.068 13.594 ABAminus -80.82, -40.1 -141.28, -176.81 -103.55, 4.37 303.13, 103.89 67.61, -155.32 in-in in 9.276 Saltbr-in 2.784 HRD-in -63.72, -62.24 77.82, -3.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 97.87 APE8-rot-in 304.34 APE67-dihe-in -66.69, -21.83 -103.0, 8.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.152 0.231 0.269 A 369 322 22 0 0 15 [[26, 321]] 1.0 4hyu CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4IZYA 8 361 427.0 1J2:60401 Type1 Inactive DFGin 3.882 13.484 ABAminus -76.71, -38.87 -145.64, -179.24 -102.44, 14.51 311.23, 93.45 52.84, -142.09 in-in in 9.149 Saltbr-in 2.738 HRD-in -72.23, -60.13 78.79, -8.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 111.06 APE8-rot-in 300.16 APE67-dihe-in -67.83, -22.42 -106.79, 8.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.239 0.261 A 369 322 22 0 0 15 [[26, 321]] 1.0 4izy CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3PZEA 7 362 427.0 CFK:1 Type1 Inactive DFGin 4.138 13.907 ABAminus -81.12, -32.94 -131.86, 179.29 -115.73, 16.97 304.08, 91.38 65.8, -99.93 in-in in 8.799 Saltbr-in 2.79 HRD-in -65.45, -61.37 74.31, -21.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 43.07 APE8-dihe-out -90.42, -23.2 APE8-rot-in 308.55 APE67-dihe-in -65.57, -26.71 -47.05, -33.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.118 None None None XRAY 2.0 0.206 0.24 A 358 347 9 0 0 9 [[26, 321]] 1.0 3pze CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.3 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4L7FA 7 362 427.0 1V5:60401 Type1 Inactive DFGin 4.168 13.903 ABAminus -92.73, -21.27 -136.46, -179.9 -126.51, 2.69 298.75, 92.07 123.75, 92.84 in-in in 9.571 Saltbr-in 2.717 HRD-in -73.68, -60.59 73.9, -18.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 56.52 APE9-dihe-na -75.12, 136.19 APE8-dihe-in -88.12, 112.11 APE8-rot-in 306.44 APE67-dihe-in -64.04, -21.62 -99.03, -5.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.839 APE9-dist-out 11.687 None None None XRAY 1.95 0.162 0.198 A 367 343 13 0 0 13 [[26, 321]] 1.0 4l7f CMGC_MAPK8_HUMAN CMGC 4.4e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3ELJA 7 364 427.0 GS7:365 Type1 Inactive DFGin 4.261 13.845 ABAminus -96.2, -23.23 -129.0, 175.64 -123.66, 12.92 303.89, 93.13 80.21, -148.51 in-in in 9.276 Saltbr-in 3.436 HRD-in -62.88, -61.88 76.44, -14.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -113.33, 122.34 APE9-dihe-na -76.53, 136.67 APE8-dihe-in -80.59, 119.63 APE8-rot-in 296.46 APE67-dihe-in -59.78, -20.24 -110.49, 3.47 APE12-dist-out 20.996 APE11-dist-out 15.822 APE10-dist-out 16.334 APE9-dist-out 11.435 None None None XRAY 1.8 0.188 0.215 A 369 347 6 0 0 6 [[26, 321]] 1.0 3elj CMGC_MAPK8_HUMAN CMGC 4.5e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4AWIA 8 364 427.0 AQ2:1365 Type1 Inactive DFGin 4.46 13.936 ABAminus -87.42, -26.01 -133.81, 169.02 -108.8, 6.11 295.82, 101.28 92.5, -161.91 in-in in 8.905 Saltbr-in 2.743 HRD-in -70.34, -61.6 77.73, -9.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -85.55, 146.28 APE9-dihe-na -95.6, 128.29 APE8-dihe-in -89.62, 121.11 APE8-rot-in 309.81 APE67-dihe-in -66.82, -18.55 -120.34, 14.07 APE12-dist-out 18.834 APE11-dist-out 14.905 APE10-dist-out 16.425 APE9-dist-out 11.46 None None None XRAY 1.91 0.188 0.219 A 369 352 5 0 0 5 [[26, 321]] 1.0 4awi CMGC_MAPK8_HUMAN CMGC 4.5e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
5LW1B 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.42 14.448 ABAminus -83.29, -51.84 -118.5, -177.73 -115.08, 20.0 298.98, 87.21 71.2, -159.63 out-out out 10.43 Saltbr-out 3.812 HRD-in -68.61, -60.19 64.51, 12.83 out-out-out SNCooo out-out ActLoopNT-out 6.477 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.58, 144.4 APE9-dihe-na -122.04, 105.79 APE8-dihe-out -71.41, -33.58 APE8-rot-in 307.18 APE67-dihe-in -61.62, -32.85 -63.18, -22.53 APE12-dist-out 20.035 APE11-dist-out 18.203 APE10-dist-out 13.764 APE9-dist-out 11.75 None None None XRAY 3.2 0.177 0.212 B 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
5LW1E 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.175 14.075 ABAminus -82.51, -53.19 -119.45, -176.34 -115.64, 20.66 300.14, 87.37 72.63, -160.31 in-out in 9.943 Saltbr-out 4.611 HRD-in -68.12, -61.52 63.83, 14.63 out-out-out SNCooo out-out ActLoopNT-out 6.883 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.31, 145.55 APE9-dihe-na -120.94, 104.94 APE8-dihe-out -71.75, -32.64 APE8-rot-in 307.04 APE67-dihe-in -62.19, -31.77 -62.28, -22.63 APE12-dist-out 20.091 APE11-dist-out 18.388 APE10-dist-out 14.086 APE9-dist-out 12.001 None None None XRAY 3.2 0.177 0.212 E 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
5LW1H 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.13 14.378 ABAminus -82.43, -51.23 -118.2, -176.9 -114.7, 20.75 298.45, 87.29 72.11, -159.03 out-out out 10.285 Saltbr-out 3.738 HRD-in -69.31, -61.29 63.64, 13.39 out-out-out SNCooo out-out ActLoopNT-out 6.474 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.56, 144.9 APE9-dihe-na -119.98, 105.48 APE8-dihe-out -71.78, -33.35 APE8-rot-in 307.69 APE67-dihe-in -61.37, -31.81 -63.06, -22.73 APE12-dist-out 20.096 APE11-dist-out 18.369 APE10-dist-out 13.965 APE9-dist-out 11.994 None None None XRAY 3.2 0.177 0.212 H 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4QTDA 6 363 427.0 38Z:424,ANP:425 Type1,Allosteric Inactive DFGin 4.279 13.95 ABAminus -89.69, -21.2 -135.34, 171.77 -115.48, 9.24 298.02, 89.8 87.52, -156.74 in-out in 9.593 Saltbr-out 4.153 HRD-in -75.36, -55.62 72.51, -12.26 out-out-out SNCooo out-out ActLoopNT-out 6.689 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.32, 137.81 APE9-dihe-na -80.42, 132.23 APE8-dihe-in -83.54, 120.1 APE8-rot-in 296.41 APE67-dihe-in -61.39, -20.52 -109.55, -3.05 APE12-dist-out 21.14 APE11-dist-out 16.032 APE10-dist-out 16.517 APE9-dist-out 11.147 None None None XRAY 1.5 0.167 0.192 A 364 355 3 0 0 3 [[26, 321]] 1.0 4qtd CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
9FT9A 7 363 427.0 ANP:401 ATPlike Inactive DFGin 6.201 13.681 BLAminus -138.37, -170.04 58.94, 78.24 -92.66, 22.82 315.32, 103.73 -63.89, -26.18 in-out in 8.542 Saltbr-out 3.842 HRD-in -66.92, -47.02 65.13, 0.51 out-in-out SNCoio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -150.17, 156.5 APE9-dihe-na -75.27, -52.01 APE8-dihe-in -88.35, 100.07 APE8-rot-in 310.81 APE67-dihe-in -64.72, -11.39 -102.84, 1.94 APE12-dist-out 5.91 APE11-dist-in 10.581 APE10-dist-out 8.079 APE9-dist-out 10.949 None None None XRAY 2.35 0.234 0.27 A 360 357 0 0 0 0 [[26, 321]] 1.0 9ft9 CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3V3VA 7 363 427.0 MYU:401 Type1 Inactive DFGin 6.827 13.786 BLAminus -143.77, -172.33 52.69, 90.19 -99.08, 8.98 306.34, 125.67 -39.78, -30.71 in-in in 8.036 Saltbr-in 2.882 HRD-in -67.72, -38.9 75.22, -25.09 in-in-out SNCiio in-out ActLoopNT-in 2.605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.93, -15.72 APE9-dihe-na -81.89, 141.96 APE8-dihe-in -63.44, 127.02 APE8-rot-out 31.94 APE67-dihe-in -66.37, -23.13 -30.24, -61.71 APE12-dist-in 12.804 APE11-dist-in 12.81 APE10-dist-in 7.648 APE9-dist-in 5.1 None None None XRAY 2.7 0.229 0.266 A 379 351 6 0 0 4 [[26, 321]] 1.0 3v3v CMGC_MAPK8_HUMAN CMGC 3.3e-84 288.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2GMXA 8 364 427.0 877:60901 Type1 Inactive DFGin 6.415 15.103 BLAminus -169.49, -165.44 17.67, 94.27 -93.05, 32.73 281.95, 52.09 -74.74, -22.92 in-in in 9.246 Saltbr-in 3.451 HRD-in -84.23, -59.06 73.39, 47.64 in-in-out SNCiio in-out ActLoopNT-in 2.733 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -71.92, -33.15 APE9-dihe-na -81.6, 112.65 APE8-dihe-in -25.7, 132.77 APE8-rot-out 32.67 APE67-dihe-in -46.1, -17.73 -58.05, -70.61 APE12-dist-in 10.542 APE11-dist-in 13.183 APE10-dist-in 7.851 APE9-dist-in 4.945 T183E,Y185E None None XRAY 3.5 0.278 0.351 A 370 357 0 0 0 0 [[26, 321]] 1.0 2gmx CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
4UX9B 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.827 14.001 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.603 Saltbr-in 2.942 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.582 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.361 APE11-dist-in 12.149 APE10-dist-in 6.527 APE9-dist-in 4.691 None None None XRAY 2.34 0.202 0.24 B 364 327 14 0 0 6 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2G01B 9 364 427.0 73Q:61001 Type1 Inactive DFGin 5.733 14.712 None -124.05, -159.93 70.3, -99.04 78.28, -8.58 269.85, 26.32 -60.64, -29.84 in-in in 9.31 Saltbr-in 3.522 HRD-in -75.33, -51.61 81.6, -31.16 in-in-out SNCiio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -55.32, -77.05 APE9-dihe-na -50.72, 131.97 APE8-dihe-in -62.41, 127.97 APE8-rot-out 179.45 APE67-dihe-in -34.47, -20.37 -26.15, -85.34 APE12-dist-in 12.643 APE11-dist-in 12.844 APE10-dist-in 7.326 APE9-dist-in 4.757 T183E,Y185E None None XRAY 3.5 0.296 0.354 B 370 356 0 0 0 0 [[26, 321]] 1.0 2g01 CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
2GMXB 7 364 427.0 877:61001 Type1 Inactive DFGin 5.611 13.943 None -106.95, -175.57 54.48, -113.25 110.31, -6.6 279.44, 165.75 -41.3, -39.48 in-out in 8.456 Saltbr-out 4.499 HRD-in -77.53, -48.43 77.05, -21.57 out-in-in SNCoii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.75, -77.84 APE9-dihe-na -45.43, 98.08 APE8-dihe-in -37.04, 123.81 APE8-rot-in 354.32 APE67-dihe-in -25.17, -38.2 -26.5, -90.08 APE12-dist-in 11.774 APE11-dist-in 12.587 APE10-dist-in 7.247 APE9-dist-in 4.473 T183E,Y185E None None XRAY 3.5 0.278 0.351 B 370 358 0 0 0 0 [[26, 321]] 1.0 2gmx CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VULA 7 364 427.0 No_ligand No_ligand None DFGin 5.11 13.768 BLAminus -85.93, 163.21 85.46, 126.64 -150.76, 1.53 338.77, 110.45 -63.64, 22.92 in-in in 9.403 Saltbr-in 3.053 HRD-in -77.29, -39.59 61.8, -14.75 in-in-none SNCiin in-none ActLoopNT-in 2.68 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -129.09, 14.97 999.0, -38.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C79V,C116S,C137V,C163A,C213V,C245S None None XRAY 2.81 0.252 0.315 A 370 344 14 0 0 14 [[26, 321]] 1.0 3vul CMGC_MAPK8_HUMAN CMGC 2.6e-81 279.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
3VUMA 7 364 427.0 No_ligand No_ligand None DFGin 5.056 13.607 BLAminus -112.58, 170.27 77.92, 128.69 -145.25, 34.84 350.71, 122.87 -58.09, -36.69 in-in in 9.037 Saltbr-in 2.981 HRD-in -72.36, -43.79 70.87, -4.2 in-in-none SNCiin in-none ActLoopNT-in 2.929 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.29, -4.06 999.0, -24.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C41V,C79V,C116S,C137V,C163A,C213V,C245S None None XRAY 2.69 0.192 0.255 A 370 344 14 0 0 14 [[26, 321]] 1.0 3vum CMGC_MAPK8_HUMAN CMGC 2.8e-81 279.0 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8

CMGC_MAPK8 (Mitogen-activated protein kinase 8)

Total number of chains: 62
Active chains: 16
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 38 61.3% 8R5EA
DFGin BLAminus 21 33.9% AF-P45983-K1A
DFGin None 3 4.8% 2G01B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MK08_HUMAN 3O2MA P45983 7 364 427.0 46A:60701 Allosteric Active DFGin 6.41 14.267 BLAminus -152.63, 162.08 80.49, 93.8 -114.77, 18.61 304.8, 107.67 -61.69, -39.94 in-in in 8.742 Saltbr-in 2.619 HRD-in -69.47, -52.78 72.9, -13.97 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.53, -31.31 APE9-dihe-na -91.45, 126.81 APE8-dihe-in -59.5, 135.65 APE8-rot-in 301.85 APE67-dihe-in -63.02, -13.15 -75.49, -27.8 APE12-dist-in 11.207 APE11-dist-in 12.783 APE10-dist-in 7.434 APE9-dist-in 5.528 T183E,Y185E None None XRAY 2.7 0.233 0.266 A 370 358 0 0 0 0 [[26, 321]] 1.0 3o2m Homo sapiens CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3O2MB P45983 7 364 427.0 46A:60701 Allosteric Active DFGin 6.433 14.024 BLAminus -142.38, 178.22 61.31, 93.12 -105.38, 24.63 305.62, 107.49 -54.81, -31.65 in-in in 9.059 Saltbr-in 2.7 HRD-in -67.22, -47.31 66.21, -6.68 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -49.13, -35.19 APE9-dihe-na -86.25, 135.93 APE8-dihe-in -71.9, 130.6 APE8-rot-in 296.5 APE67-dihe-in -57.01, -19.27 -49.25, -52.93 APE12-dist-in 11.564 APE11-dist-in 12.879 APE10-dist-in 7.96 APE9-dist-in 5.541 T183E,Y185E None None XRAY 2.7 0.233 0.266 B 370 358 0 0 0 0 [[26, 321]] 1.0 3o2m Homo sapiens CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VUIA P45983 7 364 427.0 No_ligand No_ligand Active DFGin 6.279 13.637 BLAminus -161.71, 166.24 49.14, 98.79 -100.93, 7.58 304.49, 111.2 -57.41, -21.38 in-in in 8.445 Saltbr-in 2.751 HRD-in -80.72, -34.44 66.81, -22.35 in-in-in SNCiii in-in ActLoopNT-in 2.788 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.67, -34.53 APE9-dihe-na -81.58, 139.5 APE8-dihe-in -52.39, 128.3 APE8-rot-in 307.22 APE67-dihe-in -66.42, -12.33 -38.87, -57.39 APE12-dist-in 13.587 APE11-dist-in 13.146 APE10-dist-in 7.295 APE9-dist-in 4.59 C79V,C116S,C163A,C245S None None XRAY 2.8 0.22 0.282 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vui Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.7 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VUHA P45983 7 364 427.0 No_ligand No_ligand Active DFGin 6.245 13.536 BLAminus -148.39, 170.84 44.38, 107.19 -110.71, 10.86 305.1, 110.58 -49.1, -34.53 in-in in 8.346 Saltbr-in 2.814 HRD-in -67.84, -45.56 77.42, -28.42 in-in-in SNCiii in-in ActLoopNT-in 2.684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.33, -19.09 APE9-dihe-na -84.3, 142.26 APE8-dihe-in -58.96, 126.9 APE8-rot-in 301.88 APE67-dihe-in -66.35, -10.47 -35.08, -59.67 APE12-dist-in 13.31 APE11-dist-in 12.859 APE10-dist-in 7.142 APE9-dist-in 4.924 C116S,C163A,C245S None None XRAY 2.7 0.197 0.256 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vuh Homo sapiens CMGC_MAPK8_HUMAN CMGC 3e-84 288.7 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VUDA P45983 7 364 427.0 No_ligand No_ligand Active DFGin 6.321 13.192 BLAminus -128.97, 166.57 47.01, 116.8 -121.87, 36.87 302.27, 89.43 -73.6, -27.82 in-in in 8.32 Saltbr-in 2.706 HRD-in -64.61, -34.78 67.2, -26.38 in-in-in SNCiii in-in ActLoopNT-in 2.483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.25, -55.44 APE9-dihe-na -80.77, 154.38 APE8-dihe-in -65.03, 131.96 APE8-rot-in 311.85 APE67-dihe-in -68.72, -34.8 -46.83, -54.0 APE12-dist-in 13.351 APE11-dist-in 12.875 APE10-dist-in 6.82 APE9-dist-in 4.983 C245S None None XRAY 3.5 0.204 0.293 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vud Homo sapiens CMGC_MAPK8_HUMAN CMGC 5.6e-85 291.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VUGA P45983 7 364 427.0 No_ligand No_ligand Active DFGin 6.241 13.67 BLAminus -151.25, 155.67 63.84, 102.6 -110.8, 4.88 299.0, 108.74 -61.2, -37.22 in-in in 8.464 Saltbr-in 2.615 HRD-in -84.82, -38.91 70.88, -35.15 in-in-in SNCiii in-in ActLoopNT-in 2.628 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.41, -25.55 APE9-dihe-na -88.01, 136.95 APE8-dihe-in -41.17, 111.55 APE8-rot-in 298.57 APE67-dihe-in -72.82, -30.6 -28.21, -48.81 APE12-dist-in 13.411 APE11-dist-in 12.868 APE10-dist-in 7.045 APE9-dist-in 4.813 C116S,C245S None None XRAY 3.24 0.195 0.284 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vug Homo sapiens CMGC_MAPK8_HUMAN CMGC 1.1e-84 290.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VUKA P45983 7 364 427.0 No_ligand No_ligand Active DFGin 5.846 13.336 BLAminus -160.02, 162.58 68.67, 104.55 -110.92, -0.02 303.39, 88.83 -56.44, -11.87 in-in in 8.098 Saltbr-in 2.754 HRD-in -73.52, -45.64 80.08, -26.39 in-in-in SNCiii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.92, -26.67 APE9-dihe-na -92.92, 137.67 APE8-dihe-in -49.6, 127.14 APE8-rot-in 331.83 APE67-dihe-in -67.5, -4.18 -38.21, -62.31 APE12-dist-in 13.399 APE11-dist-in 12.898 APE10-dist-in 7.131 APE9-dist-in 4.942 C79V,C116S,C137V,C163A,C245S None None XRAY 2.95 0.229 0.302 A 370 355 3 0 0 3 [[26, 321]] 1.0 3vuk Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.2e-83 285.0 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN AF-P45983-K1A P45983 18 329 427.0 No_ligand No_ligand Active DFGin 6.415 13.643 BLAminus -143.36, 178.91 71.76, 59.86 -79.25, 6.67 305.71, 110.21 -57.24, -28.48 in-in in 8.761 Saltbr-in 2.704 HRD-in -68.06, -45.26 66.86, -8.1 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.62, -32.38 APE9-dihe-na -74.54, 148.67 APE8-dihe-in -64.82, 122.89 APE8-rot-in 305.16 APE67-dihe-in -66.57, -21.46 -45.8, -48.81 APE12-dist-in 12.864 APE11-dist-in 12.524 APE10-dist-in 6.814 APE9-dist-in 4.407 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[26, 321]] 1.0 AF-P45983-K1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.4e-84 288.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN AF-P45983-K3A P45983 18 329 427.0 No_ligand No_ligand Active DFGin 6.101 14.421 BLAminus -131.11, 176.97 65.27, 65.06 -73.24, 10.87 295.36, 94.81 -61.15, -20.86 in-in in 9.583 Saltbr-in 2.736 HRD-in -74.19, -48.13 61.63, 17.91 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.5, 167.97 APE9-dihe-na 65.01, 133.8 APE8-dihe-in -55.56, 132.77 APE8-rot-in 297.67 APE67-dihe-in -67.94, -21.16 -47.15, -46.41 APE12-dist-in 12.774 APE11-dist-in 11.096 APE10-dist-in 6.429 APE9-dist-in 3.166 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[26, 321]] 1.0 AF-P45983-K3 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.4e-84 288.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3O17A P45983 7 363 427.0 No_ligand No_ligand Active DFGin 6.128 13.992 BLAminus -143.08, -155.15 4.86, 119.05 -115.61, 15.13 291.48, 95.12 -55.48, -42.85 in-in in 8.925 Saltbr-in 2.977 HRD-in -88.38, -43.35 58.03, 10.08 in-in-in SNCiii in-in ActLoopNT-in 2.373 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.55, -54.88 APE9-dihe-na -56.03, 107.98 APE8-dihe-in -41.53, 122.11 APE8-rot-in 303.39 APE67-dihe-in -26.7, -32.66 -31.75, -85.44 APE12-dist-in 10.596 APE11-dist-in 11.643 APE10-dist-in 6.843 APE9-dist-in 4.565 T183E,Y185E None None XRAY 3.0 0.263 0.308 A 370 357 0 0 0 0 [[26, 321]] 1.0 3o17 Homo sapiens CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3O17B P45983 7 363 427.0 No_ligand No_ligand Active DFGin 6.377 13.354 BLAminus -141.52, 176.46 56.9, 126.68 -136.61, 6.27 299.25, 120.4 -50.46, -23.38 in-in in 9.214 Saltbr-in 3.093 HRD-in -88.24, -52.87 72.9, -9.22 in-in-in SNCiii in-in ActLoopNT-in 2.494 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -59.17, -32.26 APE9-dihe-na -88.08, 142.34 APE8-dihe-in -62.23, 117.26 APE8-rot-in 321.66 APE67-dihe-in -47.49, -37.82 -30.24, -67.12 APE12-dist-in 11.738 APE11-dist-in 12.434 APE10-dist-in 7.042 APE9-dist-in 4.542 T183E,Y185E None None XRAY 3.0 0.263 0.308 B 370 357 0 0 0 0 [[26, 321]] 1.0 3o17 Homo sapiens CMGC_MAPK8_HUMAN CMGC 1.6e-83 286.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2G01A P45983 10 364 427.0 73Q:60901 Type1 Active DFGin 5.994 14.611 BLAminus -138.21, 160.8 78.02, 123.65 -129.29, 5.43 293.89, 44.0 -38.65, -23.81 out-in out 10.378 Saltbr-in 3.558 HRD-in -86.8, -31.67 38.11, 34.11 in-in-in SNCiii in-in ActLoopNT-in 2.657 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.24, -50.25 APE9-dihe-na -79.72, 72.99 APE8-dihe-in -7.98, 107.48 APE8-rot-in 347.58 APE67-dihe-in -48.8, -23.78 -62.13, -32.37 APE12-dist-in 12.169 APE11-dist-in 12.925 APE10-dist-in 7.597 APE9-dist-in 4.571 T183E,Y185E None None XRAY 3.5 0.296 0.354 A 370 355 0 0 0 0 [[26, 321]] 1.0 2g01 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2H96A P45983 7 364 427.0 893:60901 Type1 Active DFGin 5.747 14.071 BLAminus -142.02, 170.57 47.6, 140.71 -141.49, -1.15 291.84, 115.53 -55.85, -8.38 in-in in 9.102 Saltbr-in 2.822 HRD-in -85.69, -41.32 64.83, 4.35 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.81, -40.52 APE9-dihe-na -68.31, 154.87 APE8-dihe-in -75.38, 102.01 APE8-rot-in 313.08 APE67-dihe-in -53.52, -10.26 -11.43, -68.01 APE12-dist-in 11.968 APE11-dist-in 12.521 APE10-dist-in 7.041 APE9-dist-in 4.451 T183E,Y185E None None XRAY 3.0 0.243 0.278 A 370 358 0 0 0 0 [[26, 321]] 1.0 2h96 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2H96B P45983 7 364 427.0 893:60902 Type1 Active DFGin 5.807 14.068 BLAminus -144.72, 174.09 54.02, 123.29 -119.24, -14.41 278.05, 179.66 -39.96, -62.74 in-in in 9.069 Saltbr-in 2.973 HRD-in -74.32, -61.93 80.7, -10.76 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.3, -36.87 APE9-dihe-na -83.37, 136.31 APE8-dihe-in -75.86, 124.1 APE8-rot-in 311.58 APE67-dihe-in -48.77, -30.54 -42.37, -58.0 APE12-dist-in 11.862 APE11-dist-in 12.758 APE10-dist-in 7.201 APE9-dist-in 5.246 T183E,Y185E None None XRAY 3.0 0.243 0.278 B 370 358 0 0 0 0 [[26, 321]] 1.0 2h96 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2NO3A P45983 8 364 427.0 859:901 Type1 Active DFGin 5.863 13.89 BLAminus -141.07, 148.97 75.82, 137.69 -138.71, 16.78 294.85, 98.43 -54.01, -64.02 in-in in 8.481 Saltbr-in 2.792 HRD-in -92.56, -31.18 61.32, -24.16 in-in-in SNCiii in-in ActLoopNT-in 2.551 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -47.4, -34.85 APE9-dihe-na -77.56, 142.56 APE8-dihe-in -59.37, 120.51 APE8-rot-in 310.95 APE67-dihe-in -29.44, -22.2 -32.85, -87.31 APE12-dist-in 11.933 APE11-dist-in 12.043 APE10-dist-in 6.66 APE9-dist-in 4.818 T183E,Y185E None None XRAY 3.2 0.233 0.276 A 370 357 0 0 0 0 [[26, 321]] 1.0 2no3 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2NO3B P45983 7 363 427.0 859:902 Type1 Active DFGin 6.499 14.159 BLAminus -157.78, 177.02 69.64, 114.69 -132.65, 1.82 296.08, 106.12 -53.25, -7.72 in-in in 9.161 Saltbr-in 3.0 HRD-in -57.79, -52.24 74.94, -7.51 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.63, -57.06 APE9-dihe-na -57.37, 144.61 APE8-dihe-in -64.67, 111.29 APE8-rot-in 358.49 APE67-dihe-in -34.54, -28.75 -26.01, -79.7 APE12-dist-in 12.833 APE11-dist-in 13.376 APE10-dist-in 7.543 APE9-dist-in 4.807 T183E,Y185E None None XRAY 3.2 0.233 0.276 B 370 357 0 0 0 0 [[26, 321]] 1.0 2no3 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 6ZR5A P45983 3 362 427.0 ANP:60402 ATPlike Inactive DFGin 3.817 14.226 ABAminus -84.03, -42.55 -114.88, 174.79 -114.82, 8.54 299.13, 101.86 79.5, -168.62 out-out out 10.002 Saltbr-out 5.031 HRD-in -56.29, -55.44 70.4, -2.27 out-out-out SNCooo out-out ActLoopNT-out 6.872 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.14 APE8-rot-out 87.08 APE67-dihe-in -67.28, -21.26 -101.91, 26.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.699 0.186 0.256 A 366 348 12 0 0 12 [[26, 321]] 1.0 6zr5 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 6ZR5B P45983 4 362 427.0 ANP:60400 ATPlike Inactive DFGin 3.867 14.072 ABAminus -85.51, -41.13 -110.19, 172.79 -115.96, 8.05 294.61, 92.39 79.48, -170.78 out-out out 10.021 Saltbr-out 4.224 HRD-in -59.93, -50.9 67.15, -3.15 out-out-out SNCooo out-out ActLoopNT-out 6.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -100.6, 89.98 APE9-dihe-na -140.16, 151.66 APE8-dihe-in -87.57, 109.71 APE8-rot-in 298.46 APE67-dihe-in -73.45, -13.54 -100.12, 16.22 APE12-dist-out 17.551 APE11-dist-in 12.898 APE10-dist-out 16.341 APE9-dist-out 11.496 None None None XRAY 2.699 0.186 0.256 B 366 359 0 0 0 0 [[26, 321]] 1.0 6zr5 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2XRWA P45983 2 364 427.0 ANP:61367 ATPlike Inactive DFGin 3.816 13.941 ABAminus -85.3, -24.5 -153.59, -177.02 -115.68, 7.02 304.14, 97.05 88.01, -156.78 in-out in 9.886 Saltbr-out 4.635 HRD-in -83.3, -58.4 77.36, -14.29 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.45, -23.57 999.0, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.33 0.166 0.187 A 371 347 16 0 0 16 [[26, 321]] 1.0 2xrw Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2XS0A P45983 6 365 427.0 ANP:1367 ATPlike Inactive DFGin 3.754 14.081 ABAminus -75.25, -22.88 -148.14, -178.22 -116.01, 26.92 303.04, 86.85 61.81, -161.42 in-out in 9.735 Saltbr-out 5.55 HRD-in -69.33, -60.51 78.49, -20.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.45 APE8-rot-out 188.87 APE67-dihe-out -73.26, -26.46 -135.55, 95.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T183V,Y185F None None XRAY 2.6 0.194 0.246 A 386 346 14 0 0 14 [[26, 321]] 1.0 2xs0 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.5e-83 284.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4UX9A P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.508 13.598 ABAminus -106.9, -65.56 -75.5, 125.74 -123.36, 16.47 304.33, 124.23 -68.62, -34.25 in-out in 8.85 Saltbr-out 3.673 HRD-in -62.88, -46.37 73.76, -28.18 out-in-in SNCoii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.3, -23.46 APE9-dihe-na -71.58, 140.2 APE8-dihe-in -64.86, 127.48 APE8-rot-in 308.5 APE67-dihe-in -60.43, -26.76 -33.69, -61.49 APE12-dist-in 11.784 APE11-dist-in 12.426 APE10-dist-in 6.631 APE9-dist-in 4.533 None None None XRAY 2.34 0.202 0.24 A 364 343 7 0 0 5 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4UX9C P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.956 13.776 ABAminus -110.49, -64.95 -89.1, 120.63 -119.14, 21.23 309.02, 115.06 -68.23, -26.49 in-out in 8.919 Saltbr-out 3.636 HRD-in -66.22, -47.15 71.23, -16.82 out-in-none SNCoin in-none ActLoopNT-in 2.569 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -79.69, -26.4 APE9-dihe-na -76.07, 142.18 APE8-dihe-in -66.37, 127.01 APE8-rot-in 305.02 APE67-dihe-in -64.57, -24.76 -35.27, -55.26 APE12-dist-none 999.0 APE11-dist-in 12.005 APE10-dist-in 6.53 APE9-dist-in 4.621 None None None XRAY 2.34 0.202 0.24 C 364 333 15 0 0 7 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4UX9D P45983 9 364 427.0 ANP:1000 ATPlike Inactive DFGin 6.755 13.406 ABAminus -120.6, -55.98 -93.07, 108.1 -98.68, 25.97 301.07, 117.04 -64.8, -33.9 in-in in 9.366 Saltbr-in 2.738 HRD-in -59.8, -49.61 70.57, -12.64 in-in-out SNCiio in-out ActLoopNT-in 2.67 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -95.31, 105.19 APE9-dihe-na -74.34, -56.46 APE8-dihe-in -76.71, 134.72 APE8-rot-out 95.68 APE67-dihe-out -66.63, -26.9 -139.86, 50.27 APE12-dist-out 14.031 APE11-dist-in 13.438 APE10-dist-out 10.823 APE9-dist-out 13.555 None None None XRAY 2.34 0.202 0.24 D 364 344 9 0 0 0 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8R5EA P45983 5 363 427.0 ANP:402,Y6K:403 ATPlike,Allosteric Inactive DFGin 4.215 13.884 ABAminus -92.07, -26.65 -133.67, 178.16 -123.93, 6.5 294.94, 97.33 89.15, -162.77 in-out in 9.521 Saltbr-out 4.842 HRD-in -77.17, -59.97 76.05, -10.25 out-out-out SNCooo out-out ActLoopNT-out 6.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.14, 143.17 APE9-dihe-na -120.32, 118.65 APE8-dihe-in -75.39, 123.94 APE8-rot-in 299.29 APE67-dihe-in -61.41, -23.9 -115.12, 4.11 APE12-dist-out 18.707 APE11-dist-out 15.325 APE10-dist-out 16.68 APE9-dist-out 11.244 None None None XRAY 1.7 0.177 0.222 A 366 359 0 0 0 0 [[26, 321]] 1.0 8r5e Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 1UKHA P45983 9 363 427.0 No_ligand No_ligand Inactive DFGin 4.009 13.592 ABAminus -71.05, -50.54 -134.57, 170.42 -88.05, 19.73 310.31, 96.24 54.55, -119.32 in-in in 8.726 Saltbr-in 3.539 HRD-in -32.35, -66.36 74.83, -11.73 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -21.95 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.229 0.245 A 369 321 22 0 0 17 [[26, 321]] 1.0 1ukh Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4YR8A P45983 8 362 427.0 No_ligand No_ligand Inactive DFGin 3.746 13.651 ABAminus -92.48, -36.82 -128.7, -177.95 -116.24, 9.95 302.59, 109.3 79.22, -159.79 in-in in 9.397 Saltbr-in 2.717 HRD-in -91.12, -57.47 70.8, -11.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.35 APE8-dihe-in -90.35, 105.5 APE8-rot-out 50.94 APE67-dihe-in -67.62, -16.88 -108.83, 0.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.175 None None None XRAY 2.4 0.218 0.239 A 371 320 17 0 0 13 [[26, 321]] 1.0 4yr8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4YR8C P45983 10 362 427.0 No_ligand No_ligand Inactive DFGin 4.345 13.391 ABAminus -88.52, -41.45 -131.53, -175.1 -114.96, 11.59 302.69, 109.92 79.73, 999.0 in-in in 8.874 Saltbr-in 2.694 HRD-in -68.29, -62.18 77.05, -0.67 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.23 APE8-rot-none 999.0 APE67-dihe-in -64.66, -18.42 -99.29, -2.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.218 0.239 C 371 318 21 0 0 16 [[26, 321]] 1.0 4yr8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4YR8E P45983 7 362 427.0 No_ligand No_ligand Inactive DFGin 3.728 14.137 ABAminus -86.08, -36.9 -129.28, 170.42 -104.47, 7.33 299.61, 110.26 81.64, -165.5 out-out out 10.093 Saltbr-out 3.695 HRD-in -78.61, -55.83 65.3, 1.9 out-out-out SNCooo out-out ActLoopNT-out 6.891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -50.39 APE8-dihe-in -79.39, 102.65 APE8-rot-out 53.21 APE67-dihe-in -61.82, -18.77 -109.31, -0.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.794 None None None XRAY 2.4 0.218 0.239 E 371 317 17 0 0 12 [[26, 321]] 1.0 4yr8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4YR8F P45983 10 362 427.0 No_ligand No_ligand Inactive DFGin 4.607 13.334 ABAminus -92.28, -40.63 -125.1, 178.19 -117.35, 11.6 304.63, 110.41 81.03, 999.0 in-in in 8.547 Saltbr-in 2.414 HRD-in -61.32, -58.08 77.0, -3.6 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 114.52 APE8-rot-none 999.0 APE67-dihe-in -64.79, -18.18 -101.48, -2.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.218 0.239 F 371 300 38 0 0 16 [[26, 321]] 1.0 4yr8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 6F5EB P45983 7 362 427.0 No_ligand No_ligand Inactive DFGin 4.245 14.401 ABAminus -85.23, -40.02 -143.49, -172.1 -102.9, -4.9 292.34, 110.9 97.56, -150.23 in-in in 9.252 Saltbr-in 3.161 HRD-in -56.05, -56.91 72.46, 7.42 in-out-out SNCioo out-out ActLoopNT-out 7.913 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.0 APE9-dihe-na -95.81, 149.23 APE8-dihe-out -71.37, -38.95 APE8-rot-in 293.49 APE67-dihe-in -53.11, -31.53 -58.04, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.756 APE9-dist-out 11.174 None None None XRAY 2.7 0.202 0.226 B 373 346 10 0 0 4 [[26, 321]] 1.0 6f5e Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8X5MA P45983 7 363 427.0 Y4O:401 Type1 Inactive DFGin 3.829 13.721 ABAminus -82.03, -35.59 -145.84, 177.75 -109.61, 10.51 302.7, 100.16 80.95, -155.06 in-in in 9.106 Saltbr-in 2.768 HRD-in -69.78, -60.93 77.08, -7.13 in-out-out SNCioo out-out ActLoopNT-out 7.237 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.93 APE8-dihe-in -94.27, 100.92 APE8-rot-in 297.8 APE67-dihe-in -57.39, -30.56 -110.37, 11.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.16 None None CSO163 XRAY 2.0 0.195 0.234 A 363 341 16 0 0 12 [[26, 321]] 1.0 8x5m Homo sapiens CMGC_MAPK8_HUMAN CMGC 7.9e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PT8A P45983 7 363 427.0 A3O:401 Type1 Inactive DFGin 3.511 13.641 ABAminus -86.46, -36.69 -113.24, 157.51 -107.14, 5.23 297.22, 84.35 63.56, -136.9 in-out in 9.722 Saltbr-out 5.472 HRD-in -69.36, -62.04 67.14, -1.26 out-in-out SNCoio in-out ActLoopNT-in 3.259 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -78.69, 132.14 APE9-dihe-na -97.09, 6.93 APE8-dihe-in -119.44, 125.16 APE8-rot-out 77.92 APE67-dihe-in -61.62, -35.67 -102.35, -19.0 APE12-dist-none 999.0 APE11-dist-in 10.056 APE10-dist-out 10.166 APE9-dist-out 11.407 None None None XRAY 2.78 0.219 0.218 A 366 353 2 0 0 2 [[26, 321]] 1.0 8pt8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PT8B P45983 8 363 427.0 A3O:401 Type1 Inactive DFGin 3.708 13.56 ABAminus -87.46, -36.99 -114.07, 158.6 -107.2, 3.96 306.69, 95.61 61.75, -138.76 out-out out 10.014 Saltbr-out 4.707 HRD-in -65.17, -60.14 69.69, -8.9 out-out-out SNCooo out-out ActLoopNT-out 5.034 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -125.68, 169.43 APE9-dihe-na -89.29, -51.47 APE8-dihe-out 50.18, 54.05 APE8-rot-out 80.12 APE67-dihe-in -59.08, -31.41 -75.35, -27.98 APE12-dist-in 11.342 APE11-dist-in 8.524 APE10-dist-out 11.671 APE9-dist-out 8.634 None None None XRAY 2.78 0.219 0.218 B 366 354 0 0 0 0 [[26, 321]] 1.0 8pt8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PT8C P45983 7 362 427.0 A3O:401 Type1 Inactive DFGin 4.333 13.634 ABAminus -100.64, -42.98 -112.04, 163.18 -107.79, 3.91 318.61, 83.5 62.89, -142.35 in-out in 9.361 Saltbr-out 6.354 HRD-in -65.16, -58.91 71.32, -6.19 out-out-out SNCooo out-out ActLoopNT-out 5.135 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -0.16 APE9-dihe-na -89.45, -4.71 APE8-dihe-in -89.37, 113.03 APE8-rot-out 66.41 APE67-dihe-in -51.88, -31.5 -134.08, -10.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.551 APE9-dist-out 11.436 None None None XRAY 2.78 0.219 0.218 C 366 353 3 0 0 3 [[26, 321]] 1.0 8pt8 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PT9A P45983 8 363 427.0 DVI:401 Type1 Inactive DFGin 3.672 13.845 ABAminus -82.42, -42.96 -101.44, 156.25 -107.65, 10.42 293.61, 64.96 107.26, -173.51 out-in out 10.218 Saltbr-in 3.165 HRD-in -86.93, -57.09 73.38, 1.77 in-out-out SNCioo out-out ActLoopNT-out 6.35 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -132.39, 130.51 APE9-dihe-na -63.89, -49.36 APE8-dihe-out 47.93, 60.73 APE8-rot-out 86.13 APE67-dihe-in -60.85, -39.95 -75.12, -7.36 APE12-dist-in 10.069 APE11-dist-out 6.914 APE10-dist-out 10.64 APE9-dist-out 8.438 None None None XRAY 2.7 0.215 0.225 A 366 353 2 0 0 2 [[26, 321]] 1.0 8pt9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PT9B P45983 7 363 427.0 DVI:401 Type1 Inactive DFGin 3.602 13.359 ABAminus -78.87, -38.7 -110.84, 150.53 -102.26, 4.03 302.35, 93.73 66.71, -148.92 in-out in 9.405 Saltbr-out 4.004 HRD-in -82.54, -61.31 64.36, 5.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -99.2, 123.92 APE9-dihe-na -85.67, -7.28 APE8-dihe-in -87.66, 94.6 APE8-rot-out 69.53 APE67-dihe-in -57.65, -34.34 -84.42, -14.13 APE12-dist-none 999.0 APE11-dist-in 9.964 APE10-dist-out 10.65 APE9-dist-out 11.067 None None None XRAY 2.7 0.215 0.225 B 366 351 5 0 0 5 [[26, 321]] 1.0 8pt9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PT9C P45983 8 362 427.0 DVI:401 Type1 Inactive DFGin 3.804 14.256 ABAminus -88.85, -34.33 -106.1, 147.38 -98.39, 6.8 298.91, 67.63 59.14, -132.88 out-out out 10.183 Saltbr-out 3.89 HRD-in -79.93, -61.89 65.26, 3.23 out-out-out SNCooo out-out ActLoopNT-out 4.679 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.35 APE9-dihe-na -94.15, 7.09 APE8-dihe-in -84.28, 82.63 APE8-rot-out 73.62 APE67-dihe-in -62.72, -39.65 -92.57, -5.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.934 APE9-dist-out 11.223 None None None XRAY 2.7 0.215 0.225 C 366 352 3 0 0 3 [[26, 321]] 1.0 8pt9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PTAA P45983 8 363 427.0 CIF:401 Type1 Inactive DFGin 3.923 14.477 ABAminus -80.58, -61.37 -103.85, 165.38 -100.79, 23.99 295.77, 91.74 73.84, -149.47 in-in in 9.79 Saltbr-in 3.126 HRD-in -78.59, -61.53 62.23, 7.12 in-out-out SNCioo out-out ActLoopNT-out 6.47 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -130.45, 138.38 APE9-dihe-na -101.99, 109.25 APE8-dihe-in -118.89, 112.23 APE8-rot-out 53.5 APE67-dihe-in -51.79, -30.07 -95.29, -17.54 APE12-dist-in 10.569 APE11-dist-out 7.033 APE10-dist-out 10.183 APE9-dist-out 8.598 None None None XRAY 2.41 0.224 0.226 A 366 354 2 0 0 2 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PTAB P45983 7 363 427.0 CIF:401 Type1 Inactive DFGin 3.577 13.179 ABAminus -81.24, -57.35 -101.3, 158.61 -105.36, 14.2 308.93, 93.28 64.59, -148.13 in-in in 9.366 Saltbr-in 3.536 HRD-in -77.41, -61.25 61.49, 9.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.33, 168.25 APE9-dihe-na -116.9, 36.67 APE8-dihe-in -104.63, 91.0 APE8-rot-out 52.55 APE67-dihe-in -56.88, -29.41 -95.02, -21.65 APE12-dist-in 11.784 APE11-dist-in 9.152 APE10-dist-out 11.242 APE9-dist-out 10.214 None None None XRAY 2.41 0.224 0.226 B 366 352 5 0 0 5 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 8PTAC P45983 8 361 427.0 CIF:401 Type1 Inactive DFGin 3.826 14.088 ABAminus -83.97, -56.35 -97.04, 154.46 -105.76, 13.83 294.99, 32.04 63.79, -147.27 in-out in 9.723 Saltbr-out 4.528 HRD-in -77.01, -60.9 63.25, 7.56 out-out-out SNCooo out-out ActLoopNT-out 4.611 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -137.59 APE9-dihe-na -94.11, 17.64 APE8-dihe-in -81.48, 63.35 APE8-rot-out 71.39 APE67-dihe-in -58.68, -26.77 -108.19, -24.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.467 APE9-dist-out 10.78 None None None XRAY 2.41 0.224 0.226 C 366 351 3 0 0 3 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 1UKIA P45983 9 363 427.0 537:0 Type1 Inactive DFGin 4.704 13.114 ABAminus -77.11, -62.2 -116.68, -161.07 -126.7, 15.2 318.68, 71.9 41.91, -116.91 in-in in 9.169 Saltbr-in 2.916 HRD-in -66.76, -57.64 78.15, -46.3 in-out-out SNCioo out-out ActLoopNT-out 5.456 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.25 APE8-rot-in 304.87 APE67-dihe-out -76.75, -17.12 155.56, -17.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.221 0.241 A 369 328 18 0 0 13 [[26, 321]] 1.0 1uki Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4E73A P45983 8 361 427.0 0NR:60401 Type1 Inactive DFGin 3.941 13.714 ABAminus -80.5, -42.58 -144.32, -163.84 -110.6, 6.62 304.02, 132.42 68.66, -151.79 in-in in 9.116 Saltbr-in 2.603 HRD-in -76.2, -63.12 71.21, -5.48 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.49, -32.11 999.0, 34.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.249 0.282 A 369 318 23 0 0 15 [[26, 321]] 1.0 4e73 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4G1WA P45983 8 361 427.0 G1W:60401 Type1 Inactive DFGin 4.13 13.747 ABAminus -75.19, -46.06 -145.01, -166.31 -101.8, 11.35 310.93, 129.6 54.15, -150.73 in-in in 9.512 Saltbr-in 2.815 HRD-in -74.24, -60.52 76.29, -17.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.92 APE8-rot-in 305.3 APE67-dihe-in -68.41, -20.62 -111.33, 3.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.233 0.297 A 369 322 22 0 0 15 [[26, 321]] 1.0 4g1w Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4HYSA P45983 8 361 427.0 1BJ:60401 Type1 Inactive DFGin 4.144 13.704 ABAminus -65.58, -42.99 -148.13, -172.29 -105.42, 11.47 305.84, 116.47 62.72, -152.88 in-in in 9.169 Saltbr-in 2.542 HRD-in -81.1, -55.52 80.05, -13.7 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 85.27 APE8-rot-in 300.61 APE67-dihe-in -75.95, -19.65 -89.11, 15.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.415 0.249 0.295 A 369 321 23 0 0 15 [[26, 321]] 1.0 4hys Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4HYUA P45983 8 361 427.0 1BK:60401 Type1 Inactive DFGin 4.068 13.594 ABAminus -80.82, -40.1 -141.28, -176.81 -103.55, 4.37 303.13, 103.89 67.61, -155.32 in-in in 9.276 Saltbr-in 2.784 HRD-in -63.72, -62.24 77.82, -3.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 97.87 APE8-rot-in 304.34 APE67-dihe-in -66.69, -21.83 -103.0, 8.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.152 0.231 0.269 A 369 322 22 0 0 15 [[26, 321]] 1.0 4hyu Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4IZYA P45983 8 361 427.0 1J2:60401 Type1 Inactive DFGin 3.882 13.484 ABAminus -76.71, -38.87 -145.64, -179.24 -102.44, 14.51 311.23, 93.45 52.84, -142.09 in-in in 9.149 Saltbr-in 2.738 HRD-in -72.23, -60.13 78.79, -8.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 111.06 APE8-rot-in 300.16 APE67-dihe-in -67.83, -22.42 -106.79, 8.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.239 0.261 A 369 322 22 0 0 15 [[26, 321]] 1.0 4izy Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.3e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3PZEA P45983 7 362 427.0 CFK:1 Type1 Inactive DFGin 4.138 13.907 ABAminus -81.12, -32.94 -131.86, 179.29 -115.73, 16.97 304.08, 91.38 65.8, -99.93 in-in in 8.799 Saltbr-in 2.79 HRD-in -65.45, -61.37 74.31, -21.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 43.07 APE8-dihe-out -90.42, -23.2 APE8-rot-in 308.55 APE67-dihe-in -65.57, -26.71 -47.05, -33.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.118 None None None XRAY 2.0 0.206 0.24 A 358 347 9 0 0 9 [[26, 321]] 1.0 3pze Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.3 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4L7FA P45983 7 362 427.0 1V5:60401 Type1 Inactive DFGin 4.168 13.903 ABAminus -92.73, -21.27 -136.46, -179.9 -126.51, 2.69 298.75, 92.07 123.75, 92.84 in-in in 9.571 Saltbr-in 2.717 HRD-in -73.68, -60.59 73.9, -18.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 56.52 APE9-dihe-na -75.12, 136.19 APE8-dihe-in -88.12, 112.11 APE8-rot-in 306.44 APE67-dihe-in -64.04, -21.62 -99.03, -5.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.839 APE9-dist-out 11.687 None None None XRAY 1.95 0.162 0.198 A 367 343 13 0 0 13 [[26, 321]] 1.0 4l7f Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.4e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3ELJA P45983 7 364 427.0 GS7:365 Type1 Inactive DFGin 4.261 13.845 ABAminus -96.2, -23.23 -129.0, 175.64 -123.66, 12.92 303.89, 93.13 80.21, -148.51 in-in in 9.276 Saltbr-in 3.436 HRD-in -62.88, -61.88 76.44, -14.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -113.33, 122.34 APE9-dihe-na -76.53, 136.67 APE8-dihe-in -80.59, 119.63 APE8-rot-in 296.46 APE67-dihe-in -59.78, -20.24 -110.49, 3.47 APE12-dist-out 20.996 APE11-dist-out 15.822 APE10-dist-out 16.334 APE9-dist-out 11.435 None None None XRAY 1.8 0.188 0.215 A 369 347 6 0 0 6 [[26, 321]] 1.0 3elj Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.5e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4AWIA P45983 8 364 427.0 AQ2:1365 Type1 Inactive DFGin 4.46 13.936 ABAminus -87.42, -26.01 -133.81, 169.02 -108.8, 6.11 295.82, 101.28 92.5, -161.91 in-in in 8.905 Saltbr-in 2.743 HRD-in -70.34, -61.6 77.73, -9.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -85.55, 146.28 APE9-dihe-na -95.6, 128.29 APE8-dihe-in -89.62, 121.11 APE8-rot-in 309.81 APE67-dihe-in -66.82, -18.55 -120.34, 14.07 APE12-dist-out 18.834 APE11-dist-out 14.905 APE10-dist-out 16.425 APE9-dist-out 11.46 None None None XRAY 1.91 0.188 0.219 A 369 352 5 0 0 5 [[26, 321]] 1.0 4awi Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.5e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 5LW1B P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.42 14.448 ABAminus -83.29, -51.84 -118.5, -177.73 -115.08, 20.0 298.98, 87.21 71.2, -159.63 out-out out 10.43 Saltbr-out 3.812 HRD-in -68.61, -60.19 64.51, 12.83 out-out-out SNCooo out-out ActLoopNT-out 6.477 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.58, 144.4 APE9-dihe-na -122.04, 105.79 APE8-dihe-out -71.41, -33.58 APE8-rot-in 307.18 APE67-dihe-in -61.62, -32.85 -63.18, -22.53 APE12-dist-out 20.035 APE11-dist-out 18.203 APE10-dist-out 13.764 APE9-dist-out 11.75 None None None XRAY 3.2 0.177 0.212 B 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 5LW1E P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.175 14.075 ABAminus -82.51, -53.19 -119.45, -176.34 -115.64, 20.66 300.14, 87.37 72.63, -160.31 in-out in 9.943 Saltbr-out 4.611 HRD-in -68.12, -61.52 63.83, 14.63 out-out-out SNCooo out-out ActLoopNT-out 6.883 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.31, 145.55 APE9-dihe-na -120.94, 104.94 APE8-dihe-out -71.75, -32.64 APE8-rot-in 307.04 APE67-dihe-in -62.19, -31.77 -62.28, -22.63 APE12-dist-out 20.091 APE11-dist-out 18.388 APE10-dist-out 14.086 APE9-dist-out 12.001 None None None XRAY 3.2 0.177 0.212 E 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 5LW1H P45983 8 362 427.0 ADN:60401 Type1 Inactive DFGin 4.13 14.378 ABAminus -82.43, -51.23 -118.2, -176.9 -114.7, 20.75 298.45, 87.29 72.11, -159.03 out-out out 10.285 Saltbr-out 3.738 HRD-in -69.31, -61.29 63.64, 13.39 out-out-out SNCooo out-out ActLoopNT-out 6.474 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.56, 144.9 APE9-dihe-na -119.98, 105.48 APE8-dihe-out -71.78, -33.35 APE8-rot-in 307.69 APE67-dihe-in -61.37, -31.81 -63.06, -22.73 APE12-dist-out 20.096 APE11-dist-out 18.369 APE10-dist-out 13.965 APE9-dist-out 11.994 None None None XRAY 3.2 0.177 0.212 H 373 355 0 0 0 0 [[26, 321]] 1.0 5lw1 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.7e-84 288.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4QTDA P45983 6 363 427.0 38Z:424,ANP:425 Type1,Allosteric Inactive DFGin 4.279 13.95 ABAminus -89.69, -21.2 -135.34, 171.77 -115.48, 9.24 298.02, 89.8 87.52, -156.74 in-out in 9.593 Saltbr-out 4.153 HRD-in -75.36, -55.62 72.51, -12.26 out-out-out SNCooo out-out ActLoopNT-out 6.689 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.32, 137.81 APE9-dihe-na -80.42, 132.23 APE8-dihe-in -83.54, 120.1 APE8-rot-in 296.41 APE67-dihe-in -61.39, -20.52 -109.55, -3.05 APE12-dist-out 21.14 APE11-dist-out 16.032 APE10-dist-out 16.517 APE9-dist-out 11.147 None None None XRAY 1.5 0.167 0.192 A 364 355 3 0 0 3 [[26, 321]] 1.0 4qtd Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 9FT9A P45983 7 363 427.0 ANP:401 ATPlike Inactive DFGin 6.201 13.681 BLAminus -138.37, -170.04 58.94, 78.24 -92.66, 22.82 315.32, 103.73 -63.89, -26.18 in-out in 8.542 Saltbr-out 3.842 HRD-in -66.92, -47.02 65.13, 0.51 out-in-out SNCoio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -150.17, 156.5 APE9-dihe-na -75.27, -52.01 APE8-dihe-in -88.35, 100.07 APE8-rot-in 310.81 APE67-dihe-in -64.72, -11.39 -102.84, 1.94 APE12-dist-out 5.91 APE11-dist-in 10.581 APE10-dist-out 8.079 APE9-dist-out 10.949 None None None XRAY 2.35 0.234 0.27 A 360 357 0 0 0 0 [[26, 321]] 1.0 9ft9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3V3VA P45983 7 363 427.0 MYU:401 Type1 Inactive DFGin 6.827 13.786 BLAminus -143.77, -172.33 52.69, 90.19 -99.08, 8.98 306.34, 125.67 -39.78, -30.71 in-in in 8.036 Saltbr-in 2.882 HRD-in -67.72, -38.9 75.22, -25.09 in-in-out SNCiio in-out ActLoopNT-in 2.605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.93, -15.72 APE9-dihe-na -81.89, 141.96 APE8-dihe-in -63.44, 127.02 APE8-rot-out 31.94 APE67-dihe-in -66.37, -23.13 -30.24, -61.71 APE12-dist-in 12.804 APE11-dist-in 12.81 APE10-dist-in 7.648 APE9-dist-in 5.1 None None None XRAY 2.7 0.229 0.266 A 379 351 6 0 0 4 [[26, 321]] 1.0 3v3v Homo sapiens CMGC_MAPK8_HUMAN CMGC 3.3e-84 288.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2GMXA P45983 8 364 427.0 877:60901 Type1 Inactive DFGin 6.415 15.103 BLAminus -169.49, -165.44 17.67, 94.27 -93.05, 32.73 281.95, 52.09 -74.74, -22.92 in-in in 9.246 Saltbr-in 3.451 HRD-in -84.23, -59.06 73.39, 47.64 in-in-out SNCiio in-out ActLoopNT-in 2.733 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -71.92, -33.15 APE9-dihe-na -81.6, 112.65 APE8-dihe-in -25.7, 132.77 APE8-rot-out 32.67 APE67-dihe-in -46.1, -17.73 -58.05, -70.61 APE12-dist-in 10.542 APE11-dist-in 13.183 APE10-dist-in 7.851 APE9-dist-in 4.945 T183E,Y185E None None XRAY 3.5 0.278 0.351 A 370 357 0 0 0 0 [[26, 321]] 1.0 2gmx Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.827 14.001 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.603 Saltbr-in 2.942 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.582 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.361 APE11-dist-in 12.149 APE10-dist-in 6.527 APE9-dist-in 4.691 None None None XRAY 2.34 0.202 0.24 B 364 327 14 0 0 6 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2G01B P45983 9 364 427.0 73Q:61001 Type1 Inactive DFGin 5.733 14.712 None -124.05, -159.93 70.3, -99.04 78.28, -8.58 269.85, 26.32 -60.64, -29.84 in-in in 9.31 Saltbr-in 3.522 HRD-in -75.33, -51.61 81.6, -31.16 in-in-out SNCiio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -55.32, -77.05 APE9-dihe-na -50.72, 131.97 APE8-dihe-in -62.41, 127.97 APE8-rot-out 179.45 APE67-dihe-in -34.47, -20.37 -26.15, -85.34 APE12-dist-in 12.643 APE11-dist-in 12.844 APE10-dist-in 7.326 APE9-dist-in 4.757 T183E,Y185E None None XRAY 3.5 0.296 0.354 B 370 356 0 0 0 0 [[26, 321]] 1.0 2g01 Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 2GMXB P45983 7 364 427.0 877:61001 Type1 Inactive DFGin 5.611 13.943 None -106.95, -175.57 54.48, -113.25 110.31, -6.6 279.44, 165.75 -41.3, -39.48 in-out in 8.456 Saltbr-out 4.499 HRD-in -77.53, -48.43 77.05, -21.57 out-in-in SNCoii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.75, -77.84 APE9-dihe-na -45.43, 98.08 APE8-dihe-in -37.04, 123.81 APE8-rot-in 354.32 APE67-dihe-in -25.17, -38.2 -26.5, -90.08 APE12-dist-in 11.774 APE11-dist-in 12.587 APE10-dist-in 7.247 APE9-dist-in 4.473 T183E,Y185E None None XRAY 3.5 0.278 0.351 B 370 358 0 0 0 0 [[26, 321]] 1.0 2gmx Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-83 285.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VULA P45983 7 364 427.0 No_ligand No_ligand None DFGin 5.11 13.768 BLAminus -85.93, 163.21 85.46, 126.64 -150.76, 1.53 338.77, 110.45 -63.64, 22.92 in-in in 9.403 Saltbr-in 3.053 HRD-in -77.29, -39.59 61.8, -14.75 in-in-none SNCiin in-none ActLoopNT-in 2.68 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -129.09, 14.97 999.0, -38.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C79V,C116S,C137V,C163A,C213V,C245S None None XRAY 2.81 0.252 0.315 A 370 344 14 0 0 14 [[26, 321]] 1.0 3vul Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.6e-81 279.1 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
MK08_HUMAN 3VUMA P45983 7 364 427.0 No_ligand No_ligand None DFGin 5.056 13.607 BLAminus -112.58, 170.27 77.92, 128.69 -145.25, 34.84 350.71, 122.87 -58.09, -36.69 in-in in 9.037 Saltbr-in 2.981 HRD-in -72.36, -43.79 70.87, -4.2 in-in-none SNCiin in-none ActLoopNT-in 2.929 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.29, -4.06 999.0, -24.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C41V,C79V,C116S,C137V,C163A,C213V,C245S None None XRAY 2.69 0.192 0.255 A 370 344 14 0 0 14 [[26, 321]] 1.0 3vum Homo sapiens CMGC_MAPK8_HUMAN CMGC 2.8e-81 279.0 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8

CMGC_MAPK8 (Mitogen-activated protein kinase 8)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name