TKL_MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Total number of chains: 29
Active chains: 2
Uniprot: M3K7_HUMAN
Kinase Domain Residues: 36 - 286
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 27.6% AF-O43318-K1A
DFGin BLBminus 4 13.8% 2EVAA
DFGout BBAminus 4 13.8% 5GJDA
DFGin None 3 10.3% 8GW3A
DFGinter None 3 10.3% 8GW3B
DFGout None 3 10.3% 5GJFA
DFGin BLBplus 2 6.9% 4L53A
None None 2 6.9% 5J8IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O43318-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Mitogen-activated protein kinase kinase kinase 7
AF-O43318-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Mitogen-activated protein kinase kinase kinase 7
5V5NA 2.006 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno EDH Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
7NTHA 1.97 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno URW Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
7NTIA 1.98 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno UWZ Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5JGAA 2.0 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6KC Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5JGDA 3.101 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6KD Type1 31 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7
2EVAA 2.0 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno ADN Type1 31 - 305 0 None None Mitogen-activated protein kinase kinase kinase 7
4GS6A 2.2 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 1FM Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
4L3PA 2.68 Inactive DFGin‑BLBminus in-in none-none nonTYR APEdihe_aaiii APEdist_nnni 1UH Type1 31 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
5JGBA 2.8 Inactive DFGin‑BLBminus in-none none-out nonTYR APEdihe_aaoii APEdist_nnno 6JV Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
4L52A 2.54 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 1UL Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
4L53A 2.55 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo 1UO Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
8GW3A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
5JH6A 2.365 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno T92 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5GJGA 2.61 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6V5 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
8GW3B 2.05 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
8GW3C 2.05 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 25 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
8GW3D 2.05 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_iioo No_ligand No_ligand 27 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7
5E7RA 2.11 Inactive DFGout‑BBAminus none-none none-out nonTYR APEdihe_aaooi APEdist_nnno 5KW Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
2YIYA 2.49 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIY Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
4O91A 2.393 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno NG2 Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5GJDA 2.79 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno 6V3 Type2 31 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7
5J9LA 2.752 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6HF Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5J7SA 2.368 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6H3 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5GJFA 2.89 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_iiio 6V4 Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5J8IA 2.404 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6H4 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
5JK3A 2.371 Inactive None‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6L4 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
9FPDA 2.402 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaini APEdist_iiii A1IED Type1 31 - 496 0 TPO187,SEP192 None Mitogen-activated protein kinase kinase kinase 7

TKL_MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Total number of chains: 29
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 27.6% AF-O43318-K1A
DFGin BLBminus 4 13.8% 2EVAA
DFGout BBAminus 4 13.8% 5GJDA
DFGin None 3 10.3% 8GW3A
DFGinter None 3 10.3% 8GW3B
DFGout None 3 10.3% 5GJFA
DFGin BLBplus 2 6.9% 4L53A
None None 2 6.9% 5J8IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M3K7_HUMAN AF-O43318-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN AF-O43318-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 294 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5V5NA 2.006 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno EDH Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 7NTHA 1.97 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno URW Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 7NTIA 1.98 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno UWZ Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5JGAA 2.0 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6KC Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5JGDA 3.101 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6KD Type1 31 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 2EVAA 2.0 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno ADN Type1 31 - 305 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 4GS6A 2.2 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 1FM Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 4L3PA 2.68 Inactive DFGin‑BLBminus in-in none-none nonTYR APEdihe_aaiii APEdist_nnni 1UH Type1 31 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5JGBA 2.8 Inactive DFGin‑BLBminus in-none none-out nonTYR APEdihe_aaoii APEdist_nnno 6JV Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 4L52A 2.54 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 1UL Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 4L53A 2.55 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo 1UO Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 8GW3A 2.05 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5JH6A 2.365 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno T92 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5GJGA 2.61 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6V5 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 8GW3B 2.05 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 8GW3C 2.05 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 25 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 8GW3D 2.05 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_iioo No_ligand No_ligand 27 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5E7RA 2.11 Inactive DFGout‑BBAminus none-none none-out nonTYR APEdihe_aaooi APEdist_nnno 5KW Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 2YIYA 2.49 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIY Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 4O91A 2.393 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno NG2 Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5GJDA 2.79 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno 6V3 Type2 31 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5J9LA 2.752 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6HF Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5J7SA 2.368 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6H3 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5GJFA 2.89 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_iiio 6V4 Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5J8IA 2.404 Inactive None‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6H4 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 5JK3A 2.371 Inactive None‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6L4 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
M3K7_HUMAN 9FPDA 2.402 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaini APEdist_iiii A1IED Type1 31 - 496 0 TPO187,SEP192 None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens

TKL_MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism