TKL_MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Total number of chains: 29
Active chains: 2
Uniprot: M3K7_HUMAN
Kinase Domain Residues: 36 - 286
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 27.6% AF-O43318-K1A
DFGin BLBminus 4 13.8% 2EVAA
DFGout BBAminus 4 13.8% 5GJDA
DFGin None 3 10.3% 8GW3A
DFGinter None 3 10.3% 8GW3B
DFGout None 3 10.3% 5GJFA
DFGin BLBplus 2 6.9% 4L53A
None None 2 6.9% 5J8IA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K7 AF-O43318-K1A O43318 28 294 606.0 No_ligand No_ligand Active DFGin 6.4374 14.2578 BLAminus -135.91, -178.44 63.71, 68.23 -88.2, 14.53 289.23, 76.3 -60.56, -24.27 in-in in 7.8441 Saltbr-in 2.6718 HRD-in -75.91, -47.08 68.67, 3.27 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.71, 151.71 APE9-dihe-na 102.26, -179.87 APE8-dihe-in -97.74, 129.86 APE8-rot-in 305.09 APE67-dihe-in -73.84, -18.7 -49.97, -40.78 APE12-dist-in 9.189 APE11-dist-in 11.4492 APE10-dist-in 5.5101 APE9-dist-in 3.4227 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 25 25 0 [[36, 286]] 1.0 AF-O43318-K1 TKL_MAP3K7_HUMAN TKL 2.2e-74 256.2 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 AF-O43318-K3A O43318 28 294 606.0 No_ligand No_ligand Active DFGin 6.1635 14.3489 BLAminus -135.99, -175.25 61.0, 63.16 -80.15, 10.99 286.81, 77.67 -61.53, -24.03 in-in in 7.6626 Saltbr-in 2.6634 HRD-in -76.91, -44.69 67.08, -10.08 in-in-in SNCiii in-in ActLoopNT-in 2.8868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.75, 152.82 APE9-dihe-na 113.89, 175.31 APE8-dihe-in -97.7, 130.55 APE8-rot-in 301.49 APE67-dihe-in -73.62, -12.95 -49.26, -40.76 APE12-dist-in 9.2436 APE11-dist-in 11.2913 APE10-dist-in 5.3408 APE9-dist-in 3.2038 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 25 25 0 [[36, 286]] 1.0 AF-O43318-K3 TKL_MAP3K7_HUMAN TKL 2.2e-74 256.2 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5V5NA O43318 31 496 606.0 EDH:60501 Type1 Inactive DFGin 6.5876 14.5478 BLAminus -141.92, -178.79 59.02, 79.13 -99.67, 25.78 291.25, 68.92 -67.41, -33.16 in-in in 8.3138 Saltbr-in 3.0439 HRD-in -71.83, -50.08 77.81, -5.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -59.67 APE8-dihe-out -95.96, 6.95 APE8-rot-in 300.18 APE67-dihe-in -67.31, -16.79 -59.27, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7359 None None None XRAY 2.006 0.194 0.222 A 307.0 261.0 12 25 13 12 [[36, 286]] 1.0 5v5n TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 7NTHA O43318 31 496 606.0 URW:61005 Type1 Inactive DFGin 6.6 14.6866 BLAminus -129.31, 177.32 61.78, 77.98 -102.31, 30.23 284.74, 80.7 -87.75, -0.51 in-in in 8.0111 Saltbr-in 2.7508 HRD-in -72.87, -50.72 79.57, -8.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 12.58 APE8-dihe-out -94.52, 12.94 APE8-rot-in 294.46 APE67-dihe-in -61.41, -19.07 -63.12, -35.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6724 None None None XRAY 1.97 0.182 0.225 A 315.0 261.0 12 25 13 12 [[36, 286]] 1.0 7nth TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 7NTIA O43318 31 496 606.0 UWZ:61008 Type1 Inactive DFGin 6.4204 14.5538 BLAminus -130.76, 178.83 65.62, 73.15 -95.72, 12.16 294.4, 75.91 -56.88, -42.34 in-in in 7.8808 Saltbr-in 2.9975 HRD-in -69.0, -49.91 58.92, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -24.21 APE8-dihe-out -88.8, -0.54 APE8-rot-in 303.83 APE67-dihe-in -67.69, -27.19 -48.34, -37.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6111 None None None XRAY 1.98 0.222 0.249 A 315.0 262.0 11 25 14 11 [[36, 286]] 1.0 7nti TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5JGAA O43318 31 496 606.0 6KC:60601 Type1 Inactive DFGin 6.3125 14.907 BLAminus -138.35, -175.07 61.16, 69.07 -94.09, 15.06 279.24, 77.15 -67.09, -16.79 in-in in 8.0797 Saltbr-in 2.7737 HRD-in -70.94, -47.63 73.61, -8.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.31 APE8-dihe-out -108.62, 5.64 APE8-rot-in 301.33 APE67-dihe-in -66.91, -18.96 -58.36, -34.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5655 None None None XRAY 2.0 0.197 0.221 A 315.0 262.0 11 25 14 11 [[36, 286]] 1.0 5jga TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5JGDA O43318 31 495 606.0 6KD:60601 Type1 Inactive DFGin 6.2163 15.0471 BLAminus -124.56, -170.63 57.79, 67.89 -90.98, 19.51 277.3, 69.84 -60.52, -14.33 in-in in 8.0579 Saltbr-in 2.778 HRD-in -73.89, -37.5 69.51, -3.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 19.03 APE8-dihe-out -119.73, 20.13 APE8-rot-in 296.57 APE67-dihe-in -66.78, -28.75 -65.74, -36.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.796 None None None XRAY 3.101 0.183 0.215 A 315.0 262.0 11 25 14 11 [[36, 286]] 1.0 5jgd TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 2EVAA O43318 31 305 606.0 ADN:60498 Type1 Inactive DFGin 5.7824 14.5222 BLBminus -146.29, -178.1 42.05, 74.22 -66.23, 143.24 303.43, 3.21 -61.8, -26.77 in-in in 8.7485 Saltbr-in 3.2082 HRD-in -77.52, -49.32 75.21, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 39.52 APE8-dihe-in -17.89, 153.36 APE8-rot-in 310.55 APE67-dihe-in -70.66, -19.63 -64.99, -10.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0945 None None None XRAY 2.0 0.258 0.231 A 307.0 263.0 12 25 13 12 [[36, 286]] 1.0 2eva TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 4GS6A O43318 31 496 606.0 1FM:60611 Type1 Inactive DFGin 5.4999 14.1728 BLBminus -129.67, -179.57 41.4, 77.08 -68.75, 133.58 312.58, 158.89 -63.49, 999.0 in-in in 8.3663 Saltbr-in 2.861 HRD-in -70.16, -52.0 72.73, -10.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.33 APE8-dihe-out -87.29, -1.72 APE8-rot-in 306.53 APE67-dihe-in -64.56, -22.41 -54.21, -34.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8473 None None None XRAY 2.2 0.223 0.245 A 315.0 260.0 13 25 12 13 [[36, 286]] 1.0 4gs6 TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 4L3PA O43318 31 497 606.0 1UH:60601 Type1 Inactive DFGin 6.2435 14.1013 BLBminus -148.05, 172.2 65.44, 87.56 -93.45, -139.82 318.3, 136.38 69.3, 999.0 in-in in 9.2035 Saltbr-in 3.2241 HRD-in -69.78, -52.37 76.85, -47.15 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 70.27 APE8-dihe-in -55.12, 155.27 APE8-rot-in 285.77 APE67-dihe-in -53.38, -31.53 -51.61, -31.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.3076 None None None XRAY 2.68 0.231 0.268 A 315.0 260.0 13 25 12 13 [[36, 286]] 1.0 4l3p TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5JGBA O43318 31 496 606.0 6JV:60601 Type1 Inactive DFGin 5.5908 13.989 BLBminus -145.06, -173.63 52.01, 67.65 -65.21, 125.5 292.1, 94.42 -71.6, -10.74 in-none in 7.9616 Saltbr-none 999.0 HRD-in -70.41, -44.87 72.22, -15.01 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 35.08 APE8-dihe-out -111.41, 10.3 APE8-rot-in 295.17 APE67-dihe-in -67.54, -25.46 -64.06, -28.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6188 None None None XRAY 2.8 0.203 0.244 A 315.0 261.0 12 25 13 12 [[36, 286]] 1.0 5jgb TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 4L52A O43318 31 496 606.0 1UL:60501 Type1 Inactive DFGin 5.1494 13.487 BLBplus -150.42, 176.09 65.79, 31.45 -100.5, 175.0 51.73, 81.32 64.67, 33.25 in-in in 8.9894 Saltbr-in 3.0514 HRD-in -68.76, -50.01 79.45, -19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 45.99 APE8-dihe-out -103.45, -13.1 APE8-rot-out 162.55 APE67-dihe-in -65.29, -18.82 -57.37, -31.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0499 None None None XRAY 2.54 0.196 0.23 A 307.0 261.0 12 25 13 12 [[36, 286]] 1.0 4l52 TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 4L53A O43318 31 496 606.0 1UO:60501 Type1 Inactive DFGin 4.7688 13.7051 BLBplus -140.66, 179.42 58.2, 36.95 -99.36, 153.21 57.95, 88.5 106.13, -69.44 in-in in 8.9056 Saltbr-in 3.0053 HRD-in -66.78, -50.92 74.3, -7.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 136.16 APE9-dihe-na 69.98, 13.11 APE8-dihe-out -112.8, -2.25 APE8-rot-in 305.51 APE67-dihe-in -62.08, -25.83 -50.94, -37.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.3769 APE9-dist-out 10.8007 None None None XRAY 2.55 0.211 0.238 A 307.0 262.0 11 25 14 11 [[36, 286]] 1.0 4l53 TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 8GW3A O43318 27 497 606.0 No_ligand No_ligand Inactive DFGin 6.6472 11.7225 None -119.33, 8.38 -158.05, 154.61 -116.24, 147.16 288.24, 68.47 -75.8, 166.21 out-out out 13.9572 Saltbr-out 9.2042 HRD-in -71.65, -49.3 87.44, -14.15 out-out-out SNCooo out-out ActLoopNT-out 10.0952 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -82.82, -0.21 APE9-dihe-na 77.02, 24.75 APE8-dihe-out -104.16, 8.77 APE8-rot-in 301.46 APE67-dihe-in -66.78, -13.89 -61.71, -40.48 APE12-dist-in 12.1847 APE11-dist-out 14.8778 APE10-dist-out 9.0724 APE9-dist-out 10.7885 None None None XRAY 2.05 0.223 0.258 A 326.0 277.0 0 25 25 0 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5JH6A O43318 31 496 606.0 T92:60601 Type1 Inactive DFGin 10.5293 14.5522 None -137.04, 121.24 -83.75, 119.82 52.98, 999.0 303.28, 108.15 999.0, 999.0 out-out out 10.4819 Saltbr-out 6.598 HRD-in -75.23, -38.87 70.62, -74.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.21 APE8-dihe-out -98.25, 8.68 APE8-rot-in 298.96 APE67-dihe-in -65.25, -26.33 -63.14, -30.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8877 None None None XRAY 2.365 0.227 0.253 A 314.0 255.0 18 25 11 14 [[36, 286]] 1.0 5jh6 TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5GJGA O43318 31 496 606.0 6V5:60601 Type1 Inactive DFGin 5.2837 13.1578 None -118.05, 171.86 68.2, 36.7 -74.01, 999.0 61.15, 90.63 999.0, 999.0 out-out out 15.749 Saltbr-out 14.4672 HRD-in -70.48, -40.96 66.77, -23.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 72.06 APE8-dihe-out -80.43, -1.77 APE8-rot-in 291.81 APE67-dihe-in -68.91, -20.48 -57.04, -35.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7194 None None None XRAY 2.61 0.183 0.221 A 315.0 259.0 14 25 11 14 [[36, 286]] 1.0 5gjg TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 8GW3B O43318 27 497 606.0 No_ligand No_ligand Inactive DFGinter 7.3073 10.8739 None -117.09, 7.66 -155.39, 153.46 -120.54, 145.11 298.27, 66.91 -71.46, 166.75 out-out out 13.5798 Saltbr-out 9.5828 HRD-in -69.79, -54.63 87.1, -10.39 out-out-out SNCooo out-out ActLoopNT-out 9.8721 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.79, -8.62 APE9-dihe-na 73.87, 28.3 APE8-dihe-out -98.45, 5.64 APE8-rot-in 294.07 APE67-dihe-in -64.55, -14.4 -62.64, -34.37 APE12-dist-in 11.4121 APE11-dist-out 15.7259 APE10-dist-out 10.0313 APE9-dist-out 10.9687 None None None XRAY 2.05 0.223 0.258 B 326.0 277.0 0 25 25 0 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 8GW3C O43318 25 497 606.0 No_ligand No_ligand Inactive DFGinter 7.0005 10.8383 None -118.88, 9.98 -158.01, 154.4 -119.85, 146.31 299.32, 82.07 -75.37, 164.49 out-none out 13.1301 Saltbr-none 999.0 HRD-in -72.49, -54.99 85.65, -8.16 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.4, -8.44 APE9-dihe-na 70.7, 25.06 APE8-dihe-out -96.14, 11.17 APE8-rot-in 290.65 APE67-dihe-in -65.82, -14.66 -63.16, -38.68 APE12-dist-in 9.5745 APE11-dist-out 14.5048 APE10-dist-out 9.4631 APE9-dist-out 10.6786 None None None XRAY 2.05 0.223 0.258 C 326.0 276.0 3 25 22 3 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 8GW3D O43318 27 495 606.0 No_ligand No_ligand Inactive DFGinter 7.4472 10.844 None -119.27, 7.31 -156.44, 153.6 -121.29, 145.39 298.84, 83.74 -68.76, 164.64 out-out out 12.8254 Saltbr-out 10.0369 HRD-in -70.85, -56.03 85.08, -6.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na 89.94, -46.56 APE9-dihe-na 70.84, 30.69 APE8-dihe-out -97.92, 9.04 APE8-rot-in 302.34 APE67-dihe-in -65.06, -14.35 -59.83, -33.2 APE12-dist-in 12.4348 APE11-dist-in 12.7132 APE10-dist-out 9.8552 APE9-dist-out 10.5691 None None None XRAY 2.05 0.223 0.258 D 326.0 274.0 3 25 22 3 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5E7RA O43318 31 496 606.0 5KW:60601 Type1 Inactive DFGout 13.4148 6.3742 BBAminus -124.11, 149.24 -152.92, 133.71 -124.39, -9.8 293.71, 147.72 -63.64, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.4, -43.76 76.77, -31.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 40.73 APE8-dihe-out -80.91, -7.3 APE8-rot-out 184.88 APE67-dihe-in -66.14, -23.36 -46.17, -36.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.503 None None None XRAY 2.11 0.221 0.246 A 314.0 242.0 31 25 12 13 [[36, 286]] 1.0 5e7r TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 2YIYA O43318 31 496 606.0 YIY:64000 Type2 Inactive DFGout 12.947 10.1979 BBAminus -124.07, -179.85 -152.49, 109.42 -94.82, 3.67 297.51, 115.87 70.85, 999.0 in-in in 7.5041 Saltbr-in 2.6823 HRD-in -62.78, -50.64 73.84, -19.4 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.78 APE8-dihe-out -112.15, -2.66 APE8-rot-in 298.45 APE67-dihe-in -62.66, -25.71 -45.14, -42.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7541 None None None XRAY 2.49 0.191 0.245 A 307.0 260.0 13 25 12 13 [[36, 286]] 1.0 2yiy TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 4O91A O43318 31 496 606.0 NG2:60601 Type2 Inactive DFGout 14.0368 10.3435 BBAminus -145.86, -177.34 -149.88, 109.81 -88.07, -8.43 303.46, 108.6 60.32, 999.0 in-in in 8.0562 Saltbr-in 2.9531 HRD-in -78.98, -58.95 79.68, -8.32 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.79 APE8-dihe-out -105.78, 12.08 APE8-rot-in 293.99 APE67-dihe-in -66.13, -19.36 -61.11, -33.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6768 None None None XRAY 2.393 0.179 0.207 A 314.0 260.0 13 25 12 13 [[36, 286]] 1.0 4o91 TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5GJDA O43318 31 495 606.0 6V3:60601 Type2 Inactive DFGout 14.2787 9.689 BBAminus -145.0, -172.05 -151.95, 104.7 -67.88, -21.89 286.07, 101.11 86.18, 157.57 in-in in 8.1394 Saltbr-in 3.4341 HRD-in -72.26, -47.43 62.5, 11.79 in-out-out SNCioo out-out ActLoopNT-out 16.2357 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 123.05 APE8-dihe-out -70.9, -8.42 APE8-rot-in 299.98 APE67-dihe-in -63.31, -33.49 -54.87, -38.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7778 None None None XRAY 2.79 0.201 0.245 A 315.0 263.0 10 25 15 10 [[36, 286]] 1.0 5gjd TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5J9LA O43318 31 496 606.0 6HF:60501 Type1 Inactive DFGout 12.964 7.5747 None -126.7, 106.14 -55.49, -39.75 -39.65, 999.0 105.32, 93.88 999.0, 999.0 in-out in 9.6191 Saltbr-out 4.6621 HRD-in -64.53, -55.8 74.12, -2.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.52 APE8-dihe-out -91.5, 21.0 APE8-rot-in 299.75 APE67-dihe-in -63.93, -32.31 -64.12, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6997 None None None XRAY 2.752 0.214 0.243 A 307.0 253.0 20 25 11 14 [[36, 286]] 1.0 5j9l TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5J7SA O43318 31 496 606.0 6H3:60601 Type1 Inactive DFGout 13.0487 9.156 None -101.18, 92.1 -53.74, 146.51 -177.4, 999.0 243.66, 99.72 999.0, 999.0 out-out out 14.9272 Saltbr-out 13.3956 HRD-in -77.38, -39.09 74.94, -52.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 69.2 APE8-dihe-out -89.42, 6.68 APE8-rot-in 299.62 APE67-dihe-in -65.9, -22.13 -58.4, -37.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1933 None None None XRAY 2.368 0.229 0.24 A 314.0 246.0 27 25 11 14 [[36, 286]] 1.0 5j7s TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5GJFA O43318 31 496 606.0 6V4:60601 Type2 Inactive DFGout 16.2993 7.8388 None -134.04, -170.38 -157.19, 87.52 -73.07, -37.29 186.83, 32.22 68.25, 76.93 in-in in 8.9949 Saltbr-in 3.4099 HRD-in -69.46, -45.21 57.64, 16.61 in-out-out SNCioo out-out ActLoopNT-out 16.1866 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -80.1, 9.26 APE9-dihe-na -97.64, -163.66 APE8-dihe-out -147.33, 35.69 APE8-rot-out 67.82 APE67-dihe-in -63.8, -37.89 -78.6, -23.97 APE12-dist-in 10.4495 APE11-dist-in 11.1789 APE10-dist-in 6.1478 APE9-dist-out 10.3151 None None None XRAY 2.89 0.199 0.234 A 315.0 268.0 5 25 25 0 [[36, 286]] 1.0 5gjf TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5J8IA O43318 31 496 606.0 6H4:60601 Type1 Inactive None 999.0 999.0 None -159.73, 176.68 -129.64, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.0352 Saltbr-in 3.2247 HRD-in -75.15, -43.7 74.93, -16.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 63.93 APE8-dihe-out -87.43, 4.87 APE8-rot-in 300.81 APE67-dihe-in -65.05, -29.22 -61.69, -29.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9955 None None None XRAY 2.404 0.224 0.244 A 314.0 255.0 18 25 10 15 [[36, 286]] 1.0 5j8i TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 5JK3A O43318 31 496 606.0 6L4:60601 Type1 Inactive None 999.0 999.0 None -131.81, 109.32 -74.46, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.6176 Saltbr-out 4.8355 HRD-in -84.09, -37.87 78.05, -48.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -69.28 APE8-dihe-out -91.26, 8.89 APE8-rot-in 294.16 APE67-dihe-in -65.11, -33.08 -64.16, -29.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6135 None None None XRAY 2.371 0.236 0.266 A 314.0 236.0 33 25 10 15 [[36, 286]] 1.0 5jk3 TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 9FPDA O43318 31 496 606.0 A1IED:60601 Type1 None DFGin 6.676 14.4767 BLAminus -130.28, -171.82 55.25, 77.32 -97.54, 29.58 293.23, 81.36 -74.32, -25.41 in-in in 8.0496 Saltbr-in 3.0776 HRD-in -74.6, -42.17 67.8, -12.87 in-in-none SNCiin in-none ActLoopNT-in 2.9968 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -117.84, 110.58 APE9-dihe-na 124.51, -160.03 APE8-dihe-in -112.48, 132.82 APE8-rot-none 999.0 APE67-dihe-in -69.76, -34.93 -42.07, -38.63 APE12-dist-in 12.6106 APE11-dist-in 11.2233 APE10-dist-in 5.9913 APE9-dist-in 3.7642 None TPO187,SEP192 TPO187,SEP192 XRAY 2.402 0.209 0.222 A 316.0 270.0 3 25 22 3 [[36, 286]] 1.0 9fpd TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7

TKL_MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Total number of chains: 29
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 27.6% AF-O43318-K1A
DFGin BLBminus 4 13.8% 2EVAA
DFGout BBAminus 4 13.8% 5GJDA
DFGin None 3 10.3% 8GW3A
DFGinter None 3 10.3% 8GW3B
DFGout None 3 10.3% 5GJFA
DFGin BLBplus 2 6.9% 4L53A
None None 2 6.9% 5J8IA

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K7 M3K7_HUMAN AF-O43318-K1A O43318 28 294 606.0 No_ligand No_ligand Active DFGin 6.4374 14.2578 BLAminus -135.91, -178.44 63.71, 68.23 -88.2, 14.53 289.23, 76.3 -60.56, -24.27 in-in in 7.8441 Saltbr-in 2.6718 HRD-in -75.91, -47.08 68.67, 3.27 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.71, 151.71 APE9-dihe-na 102.26, -179.87 APE8-dihe-in -97.74, 129.86 APE8-rot-in 305.09 APE67-dihe-in -73.84, -18.7 -49.97, -40.78 APE12-dist-in 9.189 APE11-dist-in 11.4492 APE10-dist-in 5.5101 APE9-dist-in 3.4227 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 25 25 0 [[36, 286]] 1.0 AF-O43318-K1 Homo sapiens TKL_MAP3K7_HUMAN TKL 2.2e-74 256.2 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN AF-O43318-K3A O43318 28 294 606.0 No_ligand No_ligand Active DFGin 6.1635 14.3489 BLAminus -135.99, -175.25 61.0, 63.16 -80.15, 10.99 286.81, 77.67 -61.53, -24.03 in-in in 7.6626 Saltbr-in 2.6634 HRD-in -76.91, -44.69 67.08, -10.08 in-in-in SNCiii in-in ActLoopNT-in 2.8868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.75, 152.82 APE9-dihe-na 113.89, 175.31 APE8-dihe-in -97.7, 130.55 APE8-rot-in 301.49 APE67-dihe-in -73.62, -12.95 -49.26, -40.76 APE12-dist-in 9.2436 APE11-dist-in 11.2913 APE10-dist-in 5.3408 APE9-dist-in 3.2038 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 25 25 0 [[36, 286]] 1.0 AF-O43318-K3 Homo sapiens TKL_MAP3K7_HUMAN TKL 2.2e-74 256.2 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5V5NA O43318 31 496 606.0 EDH:60501 Type1 Inactive DFGin 6.5876 14.5478 BLAminus -141.92, -178.79 59.02, 79.13 -99.67, 25.78 291.25, 68.92 -67.41, -33.16 in-in in 8.3138 Saltbr-in 3.0439 HRD-in -71.83, -50.08 77.81, -5.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -59.67 APE8-dihe-out -95.96, 6.95 APE8-rot-in 300.18 APE67-dihe-in -67.31, -16.79 -59.27, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7359 None None None XRAY 2.006 0.194 0.222 A 307.0 261.0 12 25 13 12 [[36, 286]] 1.0 5v5n Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 7NTHA O43318 31 496 606.0 URW:61005 Type1 Inactive DFGin 6.6 14.6866 BLAminus -129.31, 177.32 61.78, 77.98 -102.31, 30.23 284.74, 80.7 -87.75, -0.51 in-in in 8.0111 Saltbr-in 2.7508 HRD-in -72.87, -50.72 79.57, -8.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 12.58 APE8-dihe-out -94.52, 12.94 APE8-rot-in 294.46 APE67-dihe-in -61.41, -19.07 -63.12, -35.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6724 None None None XRAY 1.97 0.182 0.225 A 315.0 261.0 12 25 13 12 [[36, 286]] 1.0 7nth Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 7NTIA O43318 31 496 606.0 UWZ:61008 Type1 Inactive DFGin 6.4204 14.5538 BLAminus -130.76, 178.83 65.62, 73.15 -95.72, 12.16 294.4, 75.91 -56.88, -42.34 in-in in 7.8808 Saltbr-in 2.9975 HRD-in -69.0, -49.91 58.92, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -24.21 APE8-dihe-out -88.8, -0.54 APE8-rot-in 303.83 APE67-dihe-in -67.69, -27.19 -48.34, -37.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6111 None None None XRAY 1.98 0.222 0.249 A 315.0 262.0 11 25 14 11 [[36, 286]] 1.0 7nti Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5JGAA O43318 31 496 606.0 6KC:60601 Type1 Inactive DFGin 6.3125 14.907 BLAminus -138.35, -175.07 61.16, 69.07 -94.09, 15.06 279.24, 77.15 -67.09, -16.79 in-in in 8.0797 Saltbr-in 2.7737 HRD-in -70.94, -47.63 73.61, -8.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.31 APE8-dihe-out -108.62, 5.64 APE8-rot-in 301.33 APE67-dihe-in -66.91, -18.96 -58.36, -34.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5655 None None None XRAY 2.0 0.197 0.221 A 315.0 262.0 11 25 14 11 [[36, 286]] 1.0 5jga Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5JGDA O43318 31 495 606.0 6KD:60601 Type1 Inactive DFGin 6.2163 15.0471 BLAminus -124.56, -170.63 57.79, 67.89 -90.98, 19.51 277.3, 69.84 -60.52, -14.33 in-in in 8.0579 Saltbr-in 2.778 HRD-in -73.89, -37.5 69.51, -3.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 19.03 APE8-dihe-out -119.73, 20.13 APE8-rot-in 296.57 APE67-dihe-in -66.78, -28.75 -65.74, -36.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.796 None None None XRAY 3.101 0.183 0.215 A 315.0 262.0 11 25 14 11 [[36, 286]] 1.0 5jgd Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 2EVAA O43318 31 305 606.0 ADN:60498 Type1 Inactive DFGin 5.7824 14.5222 BLBminus -146.29, -178.1 42.05, 74.22 -66.23, 143.24 303.43, 3.21 -61.8, -26.77 in-in in 8.7485 Saltbr-in 3.2082 HRD-in -77.52, -49.32 75.21, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 39.52 APE8-dihe-in -17.89, 153.36 APE8-rot-in 310.55 APE67-dihe-in -70.66, -19.63 -64.99, -10.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0945 None None None XRAY 2.0 0.258 0.231 A 307.0 263.0 12 25 13 12 [[36, 286]] 1.0 2eva Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 4GS6A O43318 31 496 606.0 1FM:60611 Type1 Inactive DFGin 5.4999 14.1728 BLBminus -129.67, -179.57 41.4, 77.08 -68.75, 133.58 312.58, 158.89 -63.49, 999.0 in-in in 8.3663 Saltbr-in 2.861 HRD-in -70.16, -52.0 72.73, -10.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.33 APE8-dihe-out -87.29, -1.72 APE8-rot-in 306.53 APE67-dihe-in -64.56, -22.41 -54.21, -34.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8473 None None None XRAY 2.2 0.223 0.245 A 315.0 260.0 13 25 12 13 [[36, 286]] 1.0 4gs6 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 4L3PA O43318 31 497 606.0 1UH:60601 Type1 Inactive DFGin 6.2435 14.1013 BLBminus -148.05, 172.2 65.44, 87.56 -93.45, -139.82 318.3, 136.38 69.3, 999.0 in-in in 9.2035 Saltbr-in 3.2241 HRD-in -69.78, -52.37 76.85, -47.15 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 70.27 APE8-dihe-in -55.12, 155.27 APE8-rot-in 285.77 APE67-dihe-in -53.38, -31.53 -51.61, -31.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.3076 None None None XRAY 2.68 0.231 0.268 A 315.0 260.0 13 25 12 13 [[36, 286]] 1.0 4l3p Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5JGBA O43318 31 496 606.0 6JV:60601 Type1 Inactive DFGin 5.5908 13.989 BLBminus -145.06, -173.63 52.01, 67.65 -65.21, 125.5 292.1, 94.42 -71.6, -10.74 in-none in 7.9616 Saltbr-none 999.0 HRD-in -70.41, -44.87 72.22, -15.01 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 35.08 APE8-dihe-out -111.41, 10.3 APE8-rot-in 295.17 APE67-dihe-in -67.54, -25.46 -64.06, -28.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6188 None None None XRAY 2.8 0.203 0.244 A 315.0 261.0 12 25 13 12 [[36, 286]] 1.0 5jgb Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 4L52A O43318 31 496 606.0 1UL:60501 Type1 Inactive DFGin 5.1494 13.487 BLBplus -150.42, 176.09 65.79, 31.45 -100.5, 175.0 51.73, 81.32 64.67, 33.25 in-in in 8.9894 Saltbr-in 3.0514 HRD-in -68.76, -50.01 79.45, -19.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 45.99 APE8-dihe-out -103.45, -13.1 APE8-rot-out 162.55 APE67-dihe-in -65.29, -18.82 -57.37, -31.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0499 None None None XRAY 2.54 0.196 0.23 A 307.0 261.0 12 25 13 12 [[36, 286]] 1.0 4l52 Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 4L53A O43318 31 496 606.0 1UO:60501 Type1 Inactive DFGin 4.7688 13.7051 BLBplus -140.66, 179.42 58.2, 36.95 -99.36, 153.21 57.95, 88.5 106.13, -69.44 in-in in 8.9056 Saltbr-in 3.0053 HRD-in -66.78, -50.92 74.3, -7.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 136.16 APE9-dihe-na 69.98, 13.11 APE8-dihe-out -112.8, -2.25 APE8-rot-in 305.51 APE67-dihe-in -62.08, -25.83 -50.94, -37.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.3769 APE9-dist-out 10.8007 None None None XRAY 2.55 0.211 0.238 A 307.0 262.0 11 25 14 11 [[36, 286]] 1.0 4l53 Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 8GW3A O43318 27 497 606.0 No_ligand No_ligand Inactive DFGin 6.6472 11.7225 None -119.33, 8.38 -158.05, 154.61 -116.24, 147.16 288.24, 68.47 -75.8, 166.21 out-out out 13.9572 Saltbr-out 9.2042 HRD-in -71.65, -49.3 87.44, -14.15 out-out-out SNCooo out-out ActLoopNT-out 10.0952 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -82.82, -0.21 APE9-dihe-na 77.02, 24.75 APE8-dihe-out -104.16, 8.77 APE8-rot-in 301.46 APE67-dihe-in -66.78, -13.89 -61.71, -40.48 APE12-dist-in 12.1847 APE11-dist-out 14.8778 APE10-dist-out 9.0724 APE9-dist-out 10.7885 None None None XRAY 2.05 0.223 0.258 A 326.0 277.0 0 25 25 0 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5JH6A O43318 31 496 606.0 T92:60601 Type1 Inactive DFGin 10.5293 14.5522 None -137.04, 121.24 -83.75, 119.82 52.98, 999.0 303.28, 108.15 999.0, 999.0 out-out out 10.4819 Saltbr-out 6.598 HRD-in -75.23, -38.87 70.62, -74.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 61.21 APE8-dihe-out -98.25, 8.68 APE8-rot-in 298.96 APE67-dihe-in -65.25, -26.33 -63.14, -30.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8877 None None None XRAY 2.365 0.227 0.253 A 314.0 255.0 18 25 11 14 [[36, 286]] 1.0 5jh6 Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5GJGA O43318 31 496 606.0 6V5:60601 Type1 Inactive DFGin 5.2837 13.1578 None -118.05, 171.86 68.2, 36.7 -74.01, 999.0 61.15, 90.63 999.0, 999.0 out-out out 15.749 Saltbr-out 14.4672 HRD-in -70.48, -40.96 66.77, -23.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 72.06 APE8-dihe-out -80.43, -1.77 APE8-rot-in 291.81 APE67-dihe-in -68.91, -20.48 -57.04, -35.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7194 None None None XRAY 2.61 0.183 0.221 A 315.0 259.0 14 25 11 14 [[36, 286]] 1.0 5gjg Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 8GW3B O43318 27 497 606.0 No_ligand No_ligand Inactive DFGinter 7.3073 10.8739 None -117.09, 7.66 -155.39, 153.46 -120.54, 145.11 298.27, 66.91 -71.46, 166.75 out-out out 13.5798 Saltbr-out 9.5828 HRD-in -69.79, -54.63 87.1, -10.39 out-out-out SNCooo out-out ActLoopNT-out 9.8721 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.79, -8.62 APE9-dihe-na 73.87, 28.3 APE8-dihe-out -98.45, 5.64 APE8-rot-in 294.07 APE67-dihe-in -64.55, -14.4 -62.64, -34.37 APE12-dist-in 11.4121 APE11-dist-out 15.7259 APE10-dist-out 10.0313 APE9-dist-out 10.9687 None None None XRAY 2.05 0.223 0.258 B 326.0 277.0 0 25 25 0 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 8GW3C O43318 25 497 606.0 No_ligand No_ligand Inactive DFGinter 7.0005 10.8383 None -118.88, 9.98 -158.01, 154.4 -119.85, 146.31 299.32, 82.07 -75.37, 164.49 out-none out 13.1301 Saltbr-none 999.0 HRD-in -72.49, -54.99 85.65, -8.16 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.4, -8.44 APE9-dihe-na 70.7, 25.06 APE8-dihe-out -96.14, 11.17 APE8-rot-in 290.65 APE67-dihe-in -65.82, -14.66 -63.16, -38.68 APE12-dist-in 9.5745 APE11-dist-out 14.5048 APE10-dist-out 9.4631 APE9-dist-out 10.6786 None None None XRAY 2.05 0.223 0.258 C 326.0 276.0 3 25 22 3 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 8GW3D O43318 27 495 606.0 No_ligand No_ligand Inactive DFGinter 7.4472 10.844 None -119.27, 7.31 -156.44, 153.6 -121.29, 145.39 298.84, 83.74 -68.76, 164.64 out-out out 12.8254 Saltbr-out 10.0369 HRD-in -70.85, -56.03 85.08, -6.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na 89.94, -46.56 APE9-dihe-na 70.84, 30.69 APE8-dihe-out -97.92, 9.04 APE8-rot-in 302.34 APE67-dihe-in -65.06, -14.35 -59.83, -33.2 APE12-dist-in 12.4348 APE11-dist-in 12.7132 APE10-dist-out 9.8552 APE9-dist-out 10.5691 None None None XRAY 2.05 0.223 0.258 D 326.0 274.0 3 25 22 3 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.6e-74 255.3 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5E7RA O43318 31 496 606.0 5KW:60601 Type1 Inactive DFGout 13.4148 6.3742 BBAminus -124.11, 149.24 -152.92, 133.71 -124.39, -9.8 293.71, 147.72 -63.64, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.4, -43.76 76.77, -31.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 40.73 APE8-dihe-out -80.91, -7.3 APE8-rot-out 184.88 APE67-dihe-in -66.14, -23.36 -46.17, -36.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.503 None None None XRAY 2.11 0.221 0.246 A 314.0 242.0 31 25 12 13 [[36, 286]] 1.0 5e7r Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 2YIYA O43318 31 496 606.0 YIY:64000 Type2 Inactive DFGout 12.947 10.1979 BBAminus -124.07, -179.85 -152.49, 109.42 -94.82, 3.67 297.51, 115.87 70.85, 999.0 in-in in 7.5041 Saltbr-in 2.6823 HRD-in -62.78, -50.64 73.84, -19.4 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.78 APE8-dihe-out -112.15, -2.66 APE8-rot-in 298.45 APE67-dihe-in -62.66, -25.71 -45.14, -42.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7541 None None None XRAY 2.49 0.191 0.245 A 307.0 260.0 13 25 12 13 [[36, 286]] 1.0 2yiy Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 4O91A O43318 31 496 606.0 NG2:60601 Type2 Inactive DFGout 14.0368 10.3435 BBAminus -145.86, -177.34 -149.88, 109.81 -88.07, -8.43 303.46, 108.6 60.32, 999.0 in-in in 8.0562 Saltbr-in 2.9531 HRD-in -78.98, -58.95 79.68, -8.32 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.79 APE8-dihe-out -105.78, 12.08 APE8-rot-in 293.99 APE67-dihe-in -66.13, -19.36 -61.11, -33.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6768 None None None XRAY 2.393 0.179 0.207 A 314.0 260.0 13 25 12 13 [[36, 286]] 1.0 4o91 Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5GJDA O43318 31 495 606.0 6V3:60601 Type2 Inactive DFGout 14.2787 9.689 BBAminus -145.0, -172.05 -151.95, 104.7 -67.88, -21.89 286.07, 101.11 86.18, 157.57 in-in in 8.1394 Saltbr-in 3.4341 HRD-in -72.26, -47.43 62.5, 11.79 in-out-out SNCioo out-out ActLoopNT-out 16.2357 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 123.05 APE8-dihe-out -70.9, -8.42 APE8-rot-in 299.98 APE67-dihe-in -63.31, -33.49 -54.87, -38.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7778 None None None XRAY 2.79 0.201 0.245 A 315.0 263.0 10 25 15 10 [[36, 286]] 1.0 5gjd Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5J9LA O43318 31 496 606.0 6HF:60501 Type1 Inactive DFGout 12.964 7.5747 None -126.7, 106.14 -55.49, -39.75 -39.65, 999.0 105.32, 93.88 999.0, 999.0 in-out in 9.6191 Saltbr-out 4.6621 HRD-in -64.53, -55.8 74.12, -2.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.52 APE8-dihe-out -91.5, 21.0 APE8-rot-in 299.75 APE67-dihe-in -63.93, -32.31 -64.12, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6997 None None None XRAY 2.752 0.214 0.243 A 307.0 253.0 20 25 11 14 [[36, 286]] 1.0 5j9l Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5J7SA O43318 31 496 606.0 6H3:60601 Type1 Inactive DFGout 13.0487 9.156 None -101.18, 92.1 -53.74, 146.51 -177.4, 999.0 243.66, 99.72 999.0, 999.0 out-out out 14.9272 Saltbr-out 13.3956 HRD-in -77.38, -39.09 74.94, -52.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 69.2 APE8-dihe-out -89.42, 6.68 APE8-rot-in 299.62 APE67-dihe-in -65.9, -22.13 -58.4, -37.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1933 None None None XRAY 2.368 0.229 0.24 A 314.0 246.0 27 25 11 14 [[36, 286]] 1.0 5j7s Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5GJFA O43318 31 496 606.0 6V4:60601 Type2 Inactive DFGout 16.2993 7.8388 None -134.04, -170.38 -157.19, 87.52 -73.07, -37.29 186.83, 32.22 68.25, 76.93 in-in in 8.9949 Saltbr-in 3.4099 HRD-in -69.46, -45.21 57.64, 16.61 in-out-out SNCioo out-out ActLoopNT-out 16.1866 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -80.1, 9.26 APE9-dihe-na -97.64, -163.66 APE8-dihe-out -147.33, 35.69 APE8-rot-out 67.82 APE67-dihe-in -63.8, -37.89 -78.6, -23.97 APE12-dist-in 10.4495 APE11-dist-in 11.1789 APE10-dist-in 6.1478 APE9-dist-out 10.3151 None None None XRAY 2.89 0.199 0.234 A 315.0 268.0 5 25 25 0 [[36, 286]] 1.0 5gjf Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5J8IA O43318 31 496 606.0 6H4:60601 Type1 Inactive None 999.0 999.0 None -159.73, 176.68 -129.64, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.0352 Saltbr-in 3.2247 HRD-in -75.15, -43.7 74.93, -16.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 63.93 APE8-dihe-out -87.43, 4.87 APE8-rot-in 300.81 APE67-dihe-in -65.05, -29.22 -61.69, -29.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9955 None None None XRAY 2.404 0.224 0.244 A 314.0 255.0 18 25 10 15 [[36, 286]] 1.0 5j8i Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 5JK3A O43318 31 496 606.0 6L4:60601 Type1 Inactive None 999.0 999.0 None -131.81, 109.32 -74.46, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.6176 Saltbr-out 4.8355 HRD-in -84.09, -37.87 78.05, -48.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -69.28 APE8-dihe-out -91.26, 8.89 APE8-rot-in 294.16 APE67-dihe-in -65.11, -33.08 -64.16, -29.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6135 None None None XRAY 2.371 0.236 0.266 A 314.0 236.0 33 25 10 15 [[36, 286]] 1.0 5jk3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
MAP3K7 M3K7_HUMAN 9FPDA O43318 31 496 606.0 A1IED:60601 Type1 None DFGin 6.676 14.4767 BLAminus -130.28, -171.82 55.25, 77.32 -97.54, 29.58 293.23, 81.36 -74.32, -25.41 in-in in 8.0496 Saltbr-in 3.0776 HRD-in -74.6, -42.17 67.8, -12.87 in-in-none SNCiin in-none ActLoopNT-in 2.9968 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -117.84, 110.58 APE9-dihe-na 124.51, -160.03 APE8-dihe-in -112.48, 132.82 APE8-rot-none 999.0 APE67-dihe-in -69.76, -34.93 -42.07, -38.63 APE12-dist-in 12.6106 APE11-dist-in 11.2233 APE10-dist-in 5.9913 APE9-dist-in 3.7642 None TPO187,SEP192 TPO187,SEP192 XRAY 2.402 0.209 0.222 A 316.0 270.0 3 25 22 3 [[36, 286]] 1.0 9fpd Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7

TKL_MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name