TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 39
Active chains: 27
Family: TYR
Uniprot: LCK_HUMAN
Kinase Domain Residues: 245 - 496
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 71.8% AF-P06239-K1A
DFGout BBAminus 6 15.4% 6PDJA
DFGin BLBplus 2 5.1% 4C3FA
DFGout None 2 5.1% 2OFVA
DFGin BLBminus 1 2.6% 3B2WA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
1QPCA 231 502 509.0 ANP:904 ATPlike Active DFGin 6.61 14.416 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.702 Saltbr-in 3.096 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.856 APE11-dist-na 10.005 APE10-dist-na 12.788 APE9-dist-in 6.784 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpc TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
AF-P06239-K1A 237 504 509.0 No_ligand No_ligand Active DFGin 6.328 14.153 BLAminus -126.04, -170.13 45.11, 68.26 -81.31, 13.89 294.73, 92.3 -58.95, -32.04 in-in in 7.96 Saltbr-in 2.643 HRD-in -85.36, -45.83 65.94, -10.17 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.19, 136.15 APE9-dihe-in -124.27, 155.23 APE8-dihe-in -71.92, 86.36 APE8-rot-na 31.24 APE67-dihe-in -69.87, -19.44 -40.13, -40.16 APE12-dist-na 14.877 APE11-dist-na 10.081 APE10-dist-na 12.487 APE9-dist-in 6.732 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[245, 496]] 1.0 AF-P06239-K1 TYR_LCK_HUMAN TYR 1.2e-94 322.4 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
AF-P06239-K3A 237 504 509.0 No_ligand No_ligand Active DFGin 6.293 13.783 BLAminus -134.52, -177.41 60.79, 49.52 -69.07, 12.08 301.31, 98.31 -58.6, -28.96 in-in in 7.976 Saltbr-in 2.772 HRD-in -89.57, -43.32 67.76, -6.71 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.73, 134.23 APE9-dihe-in -125.84, 153.44 APE8-dihe-in -76.15, 84.49 APE8-rot-na 34.38 APE67-dihe-in -65.31, -15.47 -42.39, -42.12 APE12-dist-na 14.586 APE11-dist-na 9.855 APE10-dist-na 11.557 APE9-dist-in 6.459 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[245, 496]] 1.0 AF-P06239-K3 TYR_LCK_HUMAN TYR 1.2e-94 322.4 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3LCKA 231 501 509.0 No_ligand No_ligand Active DFGin 6.426 14.472 BLAminus -138.47, 177.98 54.21, 81.26 -95.02, 22.59 299.7, 94.45 -60.07, -34.51 in-in in 8.831 Saltbr-in 2.821 HRD-in -102.22, -47.61 71.69, -2.05 in-in-in SNCiii in-in ActLoopNT-in 3.002 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.94, 141.96 APE9-dihe-in -130.03, 160.62 APE8-dihe-in -57.18, 110.28 APE8-rot-na 333.88 APE67-dihe-in -69.85, -23.4 -57.11, -41.02 APE12-dist-na 14.886 APE11-dist-na 10.297 APE10-dist-na 13.085 APE9-dist-in 6.956 None PTR394 PTR394 XRAY 1.7 0.178 0.199 A 271 271 0 0 0 0 [[245, 496]] 1.0 3lck TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OF2A 231 501 509.0 547:201 Type1 Active DFGin 6.605 14.256 BLAminus -130.92, 179.58 52.61, 99.32 -112.12, 23.25 297.56, 95.88 -55.97, -39.1 in-in in 8.633 Saltbr-in 3.466 HRD-in -101.89, -47.47 69.94, -5.54 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.64, 147.2 APE9-dihe-in -135.37, 159.2 APE8-dihe-in -57.79, 111.53 APE8-rot-na 330.32 APE67-dihe-in -61.7, -24.35 -53.57, -49.18 APE12-dist-na 14.777 APE11-dist-na 10.062 APE10-dist-na 12.795 APE9-dist-in 6.865 None None None XRAY 2.0 0.26 0.261 A 271 271 0 0 0 0 [[245, 496]] 1.0 2of2 TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OF4A 231 501 509.0 979:101 Type1 Active DFGin 6.545 14.232 BLAminus -133.06, -178.99 53.91, 89.2 -103.35, 22.83 299.69, 97.75 -57.7, -37.49 in-in in 8.764 Saltbr-in 3.183 HRD-in -98.49, -49.04 70.92, -5.33 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.02, 146.22 APE9-dihe-in -134.68, 159.17 APE8-dihe-in -56.47, 112.93 APE8-rot-na 328.85 APE67-dihe-in -61.04, -24.72 -55.46, -48.9 APE12-dist-na 14.782 APE11-dist-na 10.09 APE10-dist-na 12.809 APE9-dist-in 6.869 None None None XRAY 2.7 0.264 0.296 A 271 271 0 0 0 0 [[245, 496]] 1.0 2of4 TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3BYOA 231 501 509.0 AM9:1 Type1 Active DFGin 6.609 14.951 BLAminus -136.92, 176.33 55.13, 85.04 -99.79, 29.59 302.99, 91.68 -59.79, -37.93 in-in in 8.708 Saltbr-in 2.941 HRD-in -96.3, -48.46 72.8, -7.81 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.12, 144.98 APE9-dihe-in -137.68, 156.29 APE8-dihe-in -54.73, 116.01 APE8-rot-na 327.73 APE67-dihe-in -62.67, -24.49 -60.49, -48.08 APE12-dist-na 14.62 APE11-dist-na 9.919 APE10-dist-na 12.721 APE9-dist-in 7.011 None PTR394 PTR394 XRAY 2.0 0.223 0.259 A 271 271 0 0 0 0 [[245, 496]] 1.0 3byo TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OFUA 229 501 509.0 1N9:1 Type1 Active DFGin 6.718 14.559 BLAminus -128.56, 176.04 58.95, 81.99 -93.53, 23.85 301.51, 96.63 -54.11, -42.18 in-in in 9.196 Saltbr-in 2.979 HRD-in -97.82, -52.73 71.18, -1.53 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.05, 145.38 APE9-dihe-in -130.84, 159.88 APE8-dihe-in -58.11, 117.32 APE8-rot-na 329.61 APE67-dihe-in -64.49, -21.74 -57.73, -49.99 APE12-dist-na 14.46 APE11-dist-na 9.71 APE10-dist-na 12.749 APE9-dist-in 6.878 None PTR394 PTR394 XRAY 2.0 0.228 0.291 A 273 273 0 0 0 0 [[245, 496]] 1.0 2ofu TYR_LCK_HUMAN TYR 1.3e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
1QPEA 231 501 509.0 PP2:1904 Type1 Active DFGin 6.391 14.313 BLAminus -142.96, -179.55 55.35, 67.52 -84.73, 15.63 297.65, 101.73 -55.95, -34.43 in-in in 8.023 Saltbr-in 2.692 HRD-in -108.83, -49.35 72.69, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.37, 142.25 APE9-dihe-in -130.54, 154.89 APE8-dihe-in -61.74, 112.03 APE8-rot-na 337.13 APE67-dihe-in -65.74, -24.28 -52.69, -45.66 APE12-dist-na 14.926 APE11-dist-na 10.306 APE10-dist-na 13.019 APE9-dist-in 6.87 None PTR394 PTR394 XRAY 2.0 0.189 0.254 A 279 271 0 0 0 0 [[245, 496]] 1.0 1qpe TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
1QPJA 236 501 509.0 STU:902 Type1 Active DFGin 6.667 13.91 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.129 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.703 APE11-dist-na 10.092 APE10-dist-na 12.948 APE9-dist-in 7.016 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279 266 0 0 0 0 [[245, 496]] 1.0 1qpj TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2ZM1A 231 501 509.0 KSF:513 Type1 Active DFGin 6.499 14.193 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.512 Saltbr-in 2.933 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.101 APE11-dist-na 10.35 APE10-dist-na 13.014 APE9-dist-in 6.822 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zm1 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2ZM4A 231 501 509.0 KSM:604 Type1 Active DFGin 6.636 14.9 BLAminus -125.54, 175.78 59.89, 100.94 -115.94, 31.54 296.17, 83.88 -61.97, -35.07 in-in in 8.643 Saltbr-in 2.341 HRD-in -94.46, -53.83 75.78, 0.2 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.7, 135.77 APE9-dihe-in -125.01, 150.02 APE8-dihe-in -43.28, 122.59 APE8-rot-na 354.44 APE67-dihe-in -80.95, -19.91 -67.13, -31.95 APE12-dist-na 15.349 APE11-dist-na 11.187 APE10-dist-na 13.372 APE9-dist-in 6.931 None PTR394 PTR394 XRAY 2.7 0.186 0.274 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zm4 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2ZYBA 231 501 509.0 KSL:511 Type1 Active DFGin 6.36 13.854 BLAminus -123.29, -162.69 28.22, 106.2 -121.14, 30.74 300.5, 99.58 -53.55, -45.23 in-in in 8.313 Saltbr-in 2.751 HRD-in -88.81, -51.29 76.39, -10.36 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.01, 133.28 APE9-dihe-in -125.32, 152.97 APE8-dihe-in -51.44, 112.14 APE8-rot-na 336.6 APE67-dihe-in -70.07, -21.44 -63.76, -36.56 APE12-dist-na 15.206 APE11-dist-na 10.687 APE10-dist-na 13.284 APE9-dist-in 6.92 None PTR394 PTR394 XRAY 2.55 0.183 0.291 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zyb TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AC1A 231 502 509.0 KZI:514 Type1 Active DFGin 6.487 14.542 BLAminus -131.48, -179.03 55.28, 80.68 -95.73, 16.37 295.17, 96.65 -60.65, -33.27 in-in in 8.492 Saltbr-in 2.828 HRD-in -98.47, -48.35 73.68, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.39, 135.48 APE9-dihe-in -130.85, 154.91 APE8-dihe-in -61.35, 117.59 APE8-rot-na 336.87 APE67-dihe-in -69.89, -26.11 -63.6, -40.28 APE12-dist-na 15.212 APE11-dist-na 10.525 APE10-dist-na 12.943 APE9-dist-in 6.944 None PTR394 PTR394 XRAY 1.99 0.161 0.221 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac1 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AC2A 231 502 509.0 KSE:514 Type1 Active DFGin 6.606 14.565 BLAminus -135.84, 168.64 64.15, 84.09 -100.36, 19.65 294.74, 98.08 -57.49, -38.24 in-in in 8.668 Saltbr-in 3.34 HRD-in -100.58, -48.65 73.34, -4.91 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 139.12 APE9-dihe-in -135.6, 152.46 APE8-dihe-in -59.2, 122.81 APE8-rot-na 332.56 APE67-dihe-in -68.23, -28.88 -61.81, -41.57 APE12-dist-na 15.263 APE11-dist-na 10.579 APE10-dist-na 13.021 APE9-dist-in 6.869 None PTR394 PTR394 XRAY 2.1 0.164 0.225 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac2 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AC3A 231 502 509.0 KSH:511 Type1 Active DFGin 6.459 14.631 BLAminus -147.21, 174.45 54.99, 89.06 -104.08, 27.27 302.45, 83.28 -58.22, -33.73 in-in in 8.552 Saltbr-in 2.745 HRD-in -111.81, -47.37 77.05, -14.83 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.99, 144.35 APE9-dihe-in -134.94, 154.73 APE8-dihe-in -49.27, 117.05 APE8-rot-na 333.21 APE67-dihe-in -65.53, -31.62 -66.91, -37.94 APE12-dist-na 15.272 APE11-dist-na 10.707 APE10-dist-na 13.329 APE9-dist-in 6.938 None PTR394 PTR394 XRAY 2.55 0.209 0.274 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac3 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AC4A 231 502 509.0 KZL:513 Type1 Active DFGin 6.561 14.964 BLAminus -134.05, 169.16 63.4, 83.38 -101.46, 27.47 299.41, 85.84 -61.03, -40.36 in-in in 8.623 Saltbr-in 2.849 HRD-in -99.06, -47.22 74.57, -0.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.44, 142.47 APE9-dihe-in -122.94, 163.65 APE8-dihe-in -61.25, 115.38 APE8-rot-na 337.67 APE67-dihe-in -59.59, -35.92 -64.0, -44.24 APE12-dist-na 15.174 APE11-dist-na 10.354 APE10-dist-na 13.419 APE9-dist-in 7.064 None PTR394 PTR394 XRAY 2.7 0.211 0.283 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac4 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AC5A 231 502 509.0 KZM:513 Type1 Active DFGin 6.352 13.855 BLAminus -139.87, -178.59 59.74, 72.52 -92.79, 17.42 308.98, 89.37 -47.63, -35.76 in-in in 8.403 Saltbr-in 3.207 HRD-in -107.79, -48.48 77.33, -8.64 in-in-in SNCiii in-in ActLoopNT-in 3.131 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.67, 143.58 APE9-dihe-in -137.14, 147.29 APE8-dihe-in -52.03, 120.11 APE8-rot-na 337.78 APE67-dihe-in -80.56, -23.87 -69.56, -26.75 APE12-dist-na 15.367 APE11-dist-na 10.681 APE10-dist-na 12.897 APE9-dist-in 6.839 None PTR394 PTR394 XRAY 2.5 0.171 0.268 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac5 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3ACJA 231 502 509.0 KSS:513 Type1 Active DFGin 6.497 14.552 BLAminus -135.95, -178.35 54.49, 81.98 -96.02, 16.9 296.03, 99.25 -59.02, -33.73 in-in in 8.481 Saltbr-in 2.733 HRD-in -98.9, -46.49 67.28, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.6, 139.05 APE9-dihe-in -134.1, 152.03 APE8-dihe-in -62.65, 126.38 APE8-rot-na 332.51 APE67-dihe-in -67.23, -30.82 -66.13, -39.51 APE12-dist-na 15.345 APE11-dist-na 10.61 APE10-dist-na 12.959 APE9-dist-in 6.829 None PTR394 PTR394 XRAY 2.2 0.175 0.247 A 285 272 0 0 0 0 [[245, 496]] 1.0 3acj TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3ACKA 231 502 509.0 KSR:1 Type1 Active DFGin 6.486 14.554 BLAminus -138.87, 177.35 61.26, 86.12 -103.64, 22.65 299.89, 92.45 -53.76, -45.12 in-in in 8.437 Saltbr-in 2.783 HRD-in -99.63, -48.79 75.26, -11.15 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.48, 136.12 APE9-dihe-in -129.13, 153.79 APE8-dihe-in -53.72, 121.31 APE8-rot-na 336.74 APE67-dihe-in -73.11, -30.35 -74.46, -30.93 APE12-dist-na 15.241 APE11-dist-na 10.575 APE10-dist-na 13.161 APE9-dist-in 6.928 None PTR394 PTR394 XRAY 2.6 0.18 0.265 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ack TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AD4A 231 502 509.0 KBM:1 Type1 Active DFGin 6.67 14.738 BLAminus -138.55, 178.42 55.95, 86.04 -102.66, 22.41 294.12, 99.27 -58.94, -39.61 in-in in 8.418 Saltbr-in 3.133 HRD-in -98.32, -50.74 80.19, -7.43 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.34, 135.07 APE9-dihe-in -130.61, 154.41 APE8-dihe-in -64.7, 113.98 APE8-rot-na 336.56 APE67-dihe-in -73.67, -29.83 -58.57, -33.85 APE12-dist-na 15.395 APE11-dist-na 10.595 APE10-dist-na 13.218 APE9-dist-in 6.904 None PTR394 PTR394 XRAY 2.2 0.177 0.256 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ad4 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AD5A 230 502 509.0 5PB:1 Type1 Active DFGin 6.53 14.65 BLAminus -133.26, 179.48 56.65, 87.47 -103.27, 22.64 294.72, 94.2 -60.3, -39.81 in-in in 8.66 Saltbr-in 2.675 HRD-in -100.6, -52.09 78.06, -7.01 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.99, 138.23 APE9-dihe-in -134.82, 155.62 APE8-dihe-in -60.84, 123.2 APE8-rot-na 336.01 APE67-dihe-in -67.8, -24.85 -60.78, -43.22 APE12-dist-na 15.395 APE11-dist-na 10.722 APE10-dist-na 13.049 APE9-dist-in 6.803 None PTR394 PTR394 XRAY 2.0 0.161 0.218 A 285 273 0 0 0 0 [[245, 496]] 1.0 3ad5 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AD6A 230 502 509.0 KSC:513 Type1 Active DFGin 6.606 14.617 BLAminus -137.3, 174.91 63.11, 87.06 -102.53, 22.84 293.54, 102.07 -62.24, -35.85 in-in in 8.597 Saltbr-in 2.946 HRD-in -96.19, -55.02 79.01, -5.26 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.04, 143.95 APE9-dihe-in -136.21, 160.1 APE8-dihe-in -66.15, 124.74 APE8-rot-na 332.64 APE67-dihe-in -70.22, -24.36 -63.01, -43.59 APE12-dist-na 15.086 APE11-dist-na 10.605 APE10-dist-na 13.282 APE9-dist-in 6.925 None PTR394 PTR394 XRAY 2.15 0.192 0.27 A 285 273 0 0 0 0 [[245, 496]] 1.0 3ad6 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3KXZA 238 501 509.0 925:1 Type1 Active DFGin 6.268 13.796 BLAminus -141.81, -179.26 62.44, 72.38 -97.35, 29.16 312.06, 86.33 -58.6, -39.88 in-in in 8.273 Saltbr-in 3.384 HRD-in -90.63, -51.83 75.7, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.768 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.23, 135.78 APE9-dihe-in -129.65, 157.14 APE8-dihe-in -59.67, 101.6 APE8-rot-na 19.72 APE67-dihe-in -66.72, -21.47 -50.87, -46.22 APE12-dist-na 14.442 APE11-dist-na 9.801 APE10-dist-na 12.493 APE9-dist-in 6.682 None PTR394 PTR394 XRAY 2.37 0.195 0.261 A 287 264 0 0 0 0 [[245, 496]] 1.0 3kxz TYR_LCK_HUMAN TYR 1.5e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
1QPDA 231 502 509.0 STU:902 Type1 Active DFGin 6.465 14.181 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.418 Saltbr-in 2.843 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.294 APE10-dist-na 12.967 APE9-dist-in 6.951 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpd TYR_LCK_HUMAN TYR 3.6e-93 317.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3BYMA 230 501 509.0 AM0:1 Type1.5_Back Active DFGin 6.599 14.335 BLAminus -129.71, -173.8 43.96, 88.25 -99.71, 20.36 296.76, 99.13 -53.01, -42.28 in-in in 8.649 Saltbr-in 2.617 HRD-in -95.94, -50.0 73.2, -8.73 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.01, 147.55 APE9-dihe-in -139.76, 155.99 APE8-dihe-in -53.78, 113.22 APE8-rot-na 329.24 APE67-dihe-in -65.1, -24.46 -57.96, -45.81 APE12-dist-na 14.721 APE11-dist-na 10.03 APE10-dist-na 12.842 APE9-dist-in 6.945 None PTR394 PTR394 XRAY 2.0 0.226 0.274 A 272 272 0 0 0 0 [[245, 496]] 1.0 3bym TYR_LCK_HUMAN TYR 1.3e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3KMMA 231 501 509.0 LHL:1 Type1.5_Back Active DFGin 6.863 14.83 BLAminus -127.6, -179.98 60.86, 89.79 -112.67, 27.22 299.87, 93.25 -61.87, -31.32 in-in in 8.698 Saltbr-in 3.056 HRD-in -91.14, -53.45 82.64, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.65, 152.15 APE9-dihe-in -136.18, 157.7 APE8-dihe-in -58.05, 115.06 APE8-rot-na 339.75 APE67-dihe-in -80.51, -24.68 -64.53, -28.52 APE12-dist-na 14.151 APE11-dist-na 9.71 APE10-dist-na 12.39 APE9-dist-in 6.629 Y505F PTR394 PTR394 XRAY 2.8 0.167 0.223 A 288 271 0 0 0 0 [[245, 496]] 1.0 3kmm TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3AC8A 231 501 509.0 KSK:1 Type1 Inactive DFGin 6.16 14.296 BLAminus -149.31, -179.38 58.87, 71.98 -93.0, 13.95 295.99, 89.12 -55.97, -30.75 in-out in 7.614 Saltbr-out 4.721 HRD-in -95.71, -45.58 76.13, -14.85 out-in-in SNCoii in-in ActLoopNT-in 3.155 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.54, 135.63 APE9-dihe-in -130.81, 156.67 APE8-dihe-in -56.6, 115.07 APE8-rot-na 334.98 APE67-dihe-in -68.56, -21.46 -66.79, -40.68 APE12-dist-na 15.471 APE11-dist-na 10.744 APE10-dist-na 13.165 APE9-dist-in 6.893 None PTR394 PTR394 XRAY 2.3 0.229 0.318 A 285 271 0 0 0 0 [[245, 496]] 1.0 3ac8 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3B2WA 238 500 509.0 9NH:601 Type1 Inactive DFGin 8.164 16.935 BLBminus -130.29, 174.3 30.22, 87.79 -64.26, 150.62 282.55, 10.68 -81.48, 131.12 in-in in 8.328 Saltbr-in 2.767 HRD-in -83.28, -59.73 86.44, -15.17 in-out-out SNCioo out-out ActLoopNT-out 10.517 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.56, -173.59 APE9-dihe-in -132.73, 178.81 APE8-dihe-in -73.78, 81.88 APE8-rot-na 335.17 APE67-dihe-in -55.0, -12.15 -34.45, -62.51 APE12-dist-na 14.669 APE11-dist-na 10.011 APE10-dist-na 12.66 APE9-dist-in 6.775 None None None XRAY 2.3 0.23 0.308 A 277 261 2 0 0 2 [[245, 496]] 1.0 3b2w TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3MPMA 238 498 509.0 5LK:1 Type1 Inactive DFGin 4.0 14.518 BLBplus -117.53, 162.1 59.07, 39.27 -86.64, 152.74 45.5, 92.82 74.34, 9.15 in-in in 7.941 Saltbr-in 3.284 HRD-in -88.49, -65.37 87.18, -21.73 in-out-out SNCioo out-out ActLoopNT-out 9.227 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.26 APE8-dihe-out -60.9, 40.06 APE8-rot-na 23.67 APE67-dihe-in -68.02, -9.13 -55.59, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.884 D364N None None XRAY 1.95 0.172 0.213 A 267 257 4 0 0 4 [[245, 496]] 1.0 3mpm TYR_LCK_HUMAN TYR 4.4e-94 320.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
4C3FA 238 498 509.0 7KW:1499 Type1 Inactive DFGin 3.879 14.463 BLBplus -108.47, 162.66 60.18, 42.82 -97.37, 146.43 48.08, 83.58 82.78, 5.71 in-in in 8.014 Saltbr-in 3.073 HRD-in -84.53, -65.16 86.44, -20.06 in-out-out SNCioo out-out ActLoopNT-out 9.125 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.3 APE8-dihe-in -70.1, 116.34 APE8-rot-na 22.73 APE67-dihe-in -69.5, -8.96 -127.83, -9.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.897 D364N None None XRAY 1.72 0.18 0.22 A 267 257 4 0 0 4 [[245, 496]] 1.0 4c3f TYR_LCK_HUMAN TYR 4.4e-94 320.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
6PDJA 225 500 509.0 ODJ:60601 Type1.5_Front Inactive DFGout 11.351 8.956 BBAminus -108.06, 146.7 -118.62, 138.04 -125.67, 34.93 300.23, 95.6 96.65, -2.92 out-none out 17.115 Saltbr-none 999.0 HRD-in -91.73, -46.03 72.74, -1.78 none-in-in SNCnii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.11, 126.2 APE9-dihe-in -121.94, 158.33 APE8-dihe-in -71.45, 105.31 APE8-rot-na 23.06 APE67-dihe-in -61.4, -18.91 -48.25, -48.5 APE12-dist-na 15.007 APE11-dist-na 10.591 APE10-dist-na 12.887 APE9-dist-in 6.856 None PTR394 PTR394 XRAY 1.81 0.169 0.217 A 288 271 0 0 0 0 [[245, 496]] 1.0 6pdj TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OG8A 237 499 509.0 1N8:60501 Type2 Inactive DFGout 13.881 10.992 BBAminus -146.02, -178.48 -159.06, 109.07 -91.7, -32.13 313.79, 133.51 123.25, 172.44 in-in in 7.535 Saltbr-in 2.555 HRD-in -72.68, -47.71 77.3, -17.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 90.85 APE8-rot-na 331.72 APE67-dihe-in -42.21, -25.74 -101.86, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 A 265 246 17 0 0 17 [[245, 496]] 1.0 2og8 TYR_LCK_HUMAN TYR 1.1e-94 322.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OG8B 237 499 509.0 1N8:60502 Type2 Inactive DFGout 13.773 11.422 BBAminus -151.29, 173.3 -150.55, 99.91 -84.69, -22.72 312.06, 114.32 85.84, -73.71 in-in in 7.891 Saltbr-in 2.73 HRD-in -73.85, -45.85 72.78, -12.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -121.15 APE8-rot-na 325.14 APE67-dihe-in -36.14, -21.79 -90.01, -51.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 B 265 247 16 0 0 16 [[245, 496]] 1.0 2og8 TYR_LCK_HUMAN TYR 1.1e-94 322.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3BYSA 230 501 509.0 AM5:1 Type2 Inactive DFGout 13.989 10.642 BBAminus -142.64, -177.35 -158.61, 106.94 -89.7, 9.59 310.93, 117.54 52.15, 70.11 in-in in 8.12 Saltbr-in 2.707 HRD-in -64.24, -46.91 79.98, -22.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.4 APE8-rot-na 312.02 APE67-dihe-out -44.95, -20.15 53.78, -66.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.246 0.284 A 277 255 17 0 0 17 [[245, 496]] 1.0 3bys TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
3BYUA 231 501 509.0 AM6:1 Type2 Inactive DFGout 14.194 10.6 BBAminus -142.65, -178.45 -160.75, 101.5 -80.8, 5.51 308.08, 121.67 47.71, 62.39 in-in in 8.165 Saltbr-in 3.13 HRD-in -72.18, -47.4 76.26, -12.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioao APEdist_aaai APE10-dihe-none 999.0, 103.64 APE9-dihe-in -86.73, 103.84 APE8-dihe-out -31.76, 27.45 APE8-rot-na 312.67 APE67-dihe-out -39.72, -28.73 61.22, -78.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.331 APE9-dist-in 6.591 None None None XRAY 2.3 0.232 0.278 A 277 256 15 0 0 15 [[245, 496]] 1.0 3byu TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2PL0A 231 498 509.0 STI:200 Type2 Inactive DFGout 13.439 10.98 BBAminus -123.86, 162.41 -130.4, 102.99 -85.25, -1.39 299.47, 139.85 60.55, 49.25 in-in in 8.109 Saltbr-in 2.891 HRD-in -103.3, -55.77 88.99, -24.94 in-out-in SNCioi out-in ActLoopNT-out 14.691 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.65, 127.24 APE9-dihe-in -162.32, 149.69 APE8-dihe-in -67.62, 110.43 APE8-rot-na 341.58 APE67-dihe-in -77.58, -4.79 -53.82, -46.7 APE12-dist-na 16.328 APE11-dist-na 13.494 APE10-dist-na 8.81 APE9-dist-in 5.888 None None None XRAY 2.8 0.215 0.261 A 289 268 0 0 0 0 [[245, 496]] 1.0 2pl0 TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OFVA 232 498 509.0 242:60503 Type2 Inactive DFGout 14.725 10.522 None -150.8, 177.89 -156.14, 104.83 -146.7, 29.24 58.19, 94.86 -70.67, -18.76 in-in in 8.102 Saltbr-in 2.816 HRD-in -63.81, -56.73 81.39, -17.57 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -66.38, -9.13 999.0, 161.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 A 277 243 24 0 0 17 [[245, 496]] 1.0 2ofv TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
2OFVB 232 498 509.0 242:60503 Type2 Inactive DFGout 14.631 10.661 None -147.07, -175.72 -160.36, 105.8 -148.26, 28.72 55.51, 100.37 -69.36, -20.81 in-in in 7.938 Saltbr-in 2.797 HRD-in -66.99, -53.14 73.02, -17.06 in-out-none SNCion out-none ActLoopNT-out 11.867 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.76 APE8-rot-na 999.0 APE67-dihe-in -65.32, -16.12 -30.26, -66.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 B 277 243 24 0 0 11 [[245, 496]] 1.0 2ofv TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 39
Active chains: 27
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 71.8% AF-P06239-K1A
DFGout BBAminus 6 15.4% 6PDJA
DFGin BLBplus 2 5.1% 4C3FA
DFGout None 2 5.1% 2OFVA
DFGin BLBminus 1 2.6% 3B2WA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
LCK_HUMAN 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.61 14.416 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.702 Saltbr-in 3.096 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.856 APE11-dist-na 10.005 APE10-dist-na 12.788 APE9-dist-in 6.784 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpc Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN AF-P06239-K1A P06239 237 504 509.0 No_ligand No_ligand Active DFGin 6.328 14.153 BLAminus -126.04, -170.13 45.11, 68.26 -81.31, 13.89 294.73, 92.3 -58.95, -32.04 in-in in 7.96 Saltbr-in 2.643 HRD-in -85.36, -45.83 65.94, -10.17 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.19, 136.15 APE9-dihe-in -124.27, 155.23 APE8-dihe-in -71.92, 86.36 APE8-rot-na 31.24 APE67-dihe-in -69.87, -19.44 -40.13, -40.16 APE12-dist-na 14.877 APE11-dist-na 10.081 APE10-dist-na 12.487 APE9-dist-in 6.732 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[245, 496]] 1.0 AF-P06239-K1 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.4 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN AF-P06239-K3A P06239 237 504 509.0 No_ligand No_ligand Active DFGin 6.293 13.783 BLAminus -134.52, -177.41 60.79, 49.52 -69.07, 12.08 301.31, 98.31 -58.6, -28.96 in-in in 7.976 Saltbr-in 2.772 HRD-in -89.57, -43.32 67.76, -6.71 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.73, 134.23 APE9-dihe-in -125.84, 153.44 APE8-dihe-in -76.15, 84.49 APE8-rot-na 34.38 APE67-dihe-in -65.31, -15.47 -42.39, -42.12 APE12-dist-na 14.586 APE11-dist-na 9.855 APE10-dist-na 11.557 APE9-dist-in 6.459 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[245, 496]] 1.0 AF-P06239-K3 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.4 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3LCKA P06239 231 501 509.0 No_ligand No_ligand Active DFGin 6.426 14.472 BLAminus -138.47, 177.98 54.21, 81.26 -95.02, 22.59 299.7, 94.45 -60.07, -34.51 in-in in 8.831 Saltbr-in 2.821 HRD-in -102.22, -47.61 71.69, -2.05 in-in-in SNCiii in-in ActLoopNT-in 3.002 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.94, 141.96 APE9-dihe-in -130.03, 160.62 APE8-dihe-in -57.18, 110.28 APE8-rot-na 333.88 APE67-dihe-in -69.85, -23.4 -57.11, -41.02 APE12-dist-na 14.886 APE11-dist-na 10.297 APE10-dist-na 13.085 APE9-dist-in 6.956 None PTR394 PTR394 XRAY 1.7 0.178 0.199 A 271 271 0 0 0 0 [[245, 496]] 1.0 3lck Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OF2A P06239 231 501 509.0 547:201 Type1 Active DFGin 6.605 14.256 BLAminus -130.92, 179.58 52.61, 99.32 -112.12, 23.25 297.56, 95.88 -55.97, -39.1 in-in in 8.633 Saltbr-in 3.466 HRD-in -101.89, -47.47 69.94, -5.54 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.64, 147.2 APE9-dihe-in -135.37, 159.2 APE8-dihe-in -57.79, 111.53 APE8-rot-na 330.32 APE67-dihe-in -61.7, -24.35 -53.57, -49.18 APE12-dist-na 14.777 APE11-dist-na 10.062 APE10-dist-na 12.795 APE9-dist-in 6.865 None None None XRAY 2.0 0.26 0.261 A 271 271 0 0 0 0 [[245, 496]] 1.0 2of2 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OF4A P06239 231 501 509.0 979:101 Type1 Active DFGin 6.545 14.232 BLAminus -133.06, -178.99 53.91, 89.2 -103.35, 22.83 299.69, 97.75 -57.7, -37.49 in-in in 8.764 Saltbr-in 3.183 HRD-in -98.49, -49.04 70.92, -5.33 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.02, 146.22 APE9-dihe-in -134.68, 159.17 APE8-dihe-in -56.47, 112.93 APE8-rot-na 328.85 APE67-dihe-in -61.04, -24.72 -55.46, -48.9 APE12-dist-na 14.782 APE11-dist-na 10.09 APE10-dist-na 12.809 APE9-dist-in 6.869 None None None XRAY 2.7 0.264 0.296 A 271 271 0 0 0 0 [[245, 496]] 1.0 2of4 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3BYOA P06239 231 501 509.0 AM9:1 Type1 Active DFGin 6.609 14.951 BLAminus -136.92, 176.33 55.13, 85.04 -99.79, 29.59 302.99, 91.68 -59.79, -37.93 in-in in 8.708 Saltbr-in 2.941 HRD-in -96.3, -48.46 72.8, -7.81 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.12, 144.98 APE9-dihe-in -137.68, 156.29 APE8-dihe-in -54.73, 116.01 APE8-rot-na 327.73 APE67-dihe-in -62.67, -24.49 -60.49, -48.08 APE12-dist-na 14.62 APE11-dist-na 9.919 APE10-dist-na 12.721 APE9-dist-in 7.011 None PTR394 PTR394 XRAY 2.0 0.223 0.259 A 271 271 0 0 0 0 [[245, 496]] 1.0 3byo Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OFUA P06239 229 501 509.0 1N9:1 Type1 Active DFGin 6.718 14.559 BLAminus -128.56, 176.04 58.95, 81.99 -93.53, 23.85 301.51, 96.63 -54.11, -42.18 in-in in 9.196 Saltbr-in 2.979 HRD-in -97.82, -52.73 71.18, -1.53 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.05, 145.38 APE9-dihe-in -130.84, 159.88 APE8-dihe-in -58.11, 117.32 APE8-rot-na 329.61 APE67-dihe-in -64.49, -21.74 -57.73, -49.99 APE12-dist-na 14.46 APE11-dist-na 9.71 APE10-dist-na 12.749 APE9-dist-in 6.878 None PTR394 PTR394 XRAY 2.0 0.228 0.291 A 273 273 0 0 0 0 [[245, 496]] 1.0 2ofu Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 1QPEA P06239 231 501 509.0 PP2:1904 Type1 Active DFGin 6.391 14.313 BLAminus -142.96, -179.55 55.35, 67.52 -84.73, 15.63 297.65, 101.73 -55.95, -34.43 in-in in 8.023 Saltbr-in 2.692 HRD-in -108.83, -49.35 72.69, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.37, 142.25 APE9-dihe-in -130.54, 154.89 APE8-dihe-in -61.74, 112.03 APE8-rot-na 337.13 APE67-dihe-in -65.74, -24.28 -52.69, -45.66 APE12-dist-na 14.926 APE11-dist-na 10.306 APE10-dist-na 13.019 APE9-dist-in 6.87 None PTR394 PTR394 XRAY 2.0 0.189 0.254 A 279 271 0 0 0 0 [[245, 496]] 1.0 1qpe Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.667 13.91 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.129 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.703 APE11-dist-na 10.092 APE10-dist-na 12.948 APE9-dist-in 7.016 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279 266 0 0 0 0 [[245, 496]] 1.0 1qpj Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.499 14.193 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.512 Saltbr-in 2.933 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.101 APE11-dist-na 10.35 APE10-dist-na 13.014 APE9-dist-in 6.822 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zm1 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2ZM4A P06239 231 501 509.0 KSM:604 Type1 Active DFGin 6.636 14.9 BLAminus -125.54, 175.78 59.89, 100.94 -115.94, 31.54 296.17, 83.88 -61.97, -35.07 in-in in 8.643 Saltbr-in 2.341 HRD-in -94.46, -53.83 75.78, 0.2 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.7, 135.77 APE9-dihe-in -125.01, 150.02 APE8-dihe-in -43.28, 122.59 APE8-rot-na 354.44 APE67-dihe-in -80.95, -19.91 -67.13, -31.95 APE12-dist-na 15.349 APE11-dist-na 11.187 APE10-dist-na 13.372 APE9-dist-in 6.931 None PTR394 PTR394 XRAY 2.7 0.186 0.274 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zm4 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2ZYBA P06239 231 501 509.0 KSL:511 Type1 Active DFGin 6.36 13.854 BLAminus -123.29, -162.69 28.22, 106.2 -121.14, 30.74 300.5, 99.58 -53.55, -45.23 in-in in 8.313 Saltbr-in 2.751 HRD-in -88.81, -51.29 76.39, -10.36 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.01, 133.28 APE9-dihe-in -125.32, 152.97 APE8-dihe-in -51.44, 112.14 APE8-rot-na 336.6 APE67-dihe-in -70.07, -21.44 -63.76, -36.56 APE12-dist-na 15.206 APE11-dist-na 10.687 APE10-dist-na 13.284 APE9-dist-in 6.92 None PTR394 PTR394 XRAY 2.55 0.183 0.291 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zyb Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AC1A P06239 231 502 509.0 KZI:514 Type1 Active DFGin 6.487 14.542 BLAminus -131.48, -179.03 55.28, 80.68 -95.73, 16.37 295.17, 96.65 -60.65, -33.27 in-in in 8.492 Saltbr-in 2.828 HRD-in -98.47, -48.35 73.68, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.39, 135.48 APE9-dihe-in -130.85, 154.91 APE8-dihe-in -61.35, 117.59 APE8-rot-na 336.87 APE67-dihe-in -69.89, -26.11 -63.6, -40.28 APE12-dist-na 15.212 APE11-dist-na 10.525 APE10-dist-na 12.943 APE9-dist-in 6.944 None PTR394 PTR394 XRAY 1.99 0.161 0.221 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac1 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AC2A P06239 231 502 509.0 KSE:514 Type1 Active DFGin 6.606 14.565 BLAminus -135.84, 168.64 64.15, 84.09 -100.36, 19.65 294.74, 98.08 -57.49, -38.24 in-in in 8.668 Saltbr-in 3.34 HRD-in -100.58, -48.65 73.34, -4.91 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 139.12 APE9-dihe-in -135.6, 152.46 APE8-dihe-in -59.2, 122.81 APE8-rot-na 332.56 APE67-dihe-in -68.23, -28.88 -61.81, -41.57 APE12-dist-na 15.263 APE11-dist-na 10.579 APE10-dist-na 13.021 APE9-dist-in 6.869 None PTR394 PTR394 XRAY 2.1 0.164 0.225 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac2 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AC3A P06239 231 502 509.0 KSH:511 Type1 Active DFGin 6.459 14.631 BLAminus -147.21, 174.45 54.99, 89.06 -104.08, 27.27 302.45, 83.28 -58.22, -33.73 in-in in 8.552 Saltbr-in 2.745 HRD-in -111.81, -47.37 77.05, -14.83 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.99, 144.35 APE9-dihe-in -134.94, 154.73 APE8-dihe-in -49.27, 117.05 APE8-rot-na 333.21 APE67-dihe-in -65.53, -31.62 -66.91, -37.94 APE12-dist-na 15.272 APE11-dist-na 10.707 APE10-dist-na 13.329 APE9-dist-in 6.938 None PTR394 PTR394 XRAY 2.55 0.209 0.274 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac3 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AC4A P06239 231 502 509.0 KZL:513 Type1 Active DFGin 6.561 14.964 BLAminus -134.05, 169.16 63.4, 83.38 -101.46, 27.47 299.41, 85.84 -61.03, -40.36 in-in in 8.623 Saltbr-in 2.849 HRD-in -99.06, -47.22 74.57, -0.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.44, 142.47 APE9-dihe-in -122.94, 163.65 APE8-dihe-in -61.25, 115.38 APE8-rot-na 337.67 APE67-dihe-in -59.59, -35.92 -64.0, -44.24 APE12-dist-na 15.174 APE11-dist-na 10.354 APE10-dist-na 13.419 APE9-dist-in 7.064 None PTR394 PTR394 XRAY 2.7 0.211 0.283 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac4 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AC5A P06239 231 502 509.0 KZM:513 Type1 Active DFGin 6.352 13.855 BLAminus -139.87, -178.59 59.74, 72.52 -92.79, 17.42 308.98, 89.37 -47.63, -35.76 in-in in 8.403 Saltbr-in 3.207 HRD-in -107.79, -48.48 77.33, -8.64 in-in-in SNCiii in-in ActLoopNT-in 3.131 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.67, 143.58 APE9-dihe-in -137.14, 147.29 APE8-dihe-in -52.03, 120.11 APE8-rot-na 337.78 APE67-dihe-in -80.56, -23.87 -69.56, -26.75 APE12-dist-na 15.367 APE11-dist-na 10.681 APE10-dist-na 12.897 APE9-dist-in 6.839 None PTR394 PTR394 XRAY 2.5 0.171 0.268 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ac5 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3ACJA P06239 231 502 509.0 KSS:513 Type1 Active DFGin 6.497 14.552 BLAminus -135.95, -178.35 54.49, 81.98 -96.02, 16.9 296.03, 99.25 -59.02, -33.73 in-in in 8.481 Saltbr-in 2.733 HRD-in -98.9, -46.49 67.28, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.6, 139.05 APE9-dihe-in -134.1, 152.03 APE8-dihe-in -62.65, 126.38 APE8-rot-na 332.51 APE67-dihe-in -67.23, -30.82 -66.13, -39.51 APE12-dist-na 15.345 APE11-dist-na 10.61 APE10-dist-na 12.959 APE9-dist-in 6.829 None PTR394 PTR394 XRAY 2.2 0.175 0.247 A 285 272 0 0 0 0 [[245, 496]] 1.0 3acj Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3ACKA P06239 231 502 509.0 KSR:1 Type1 Active DFGin 6.486 14.554 BLAminus -138.87, 177.35 61.26, 86.12 -103.64, 22.65 299.89, 92.45 -53.76, -45.12 in-in in 8.437 Saltbr-in 2.783 HRD-in -99.63, -48.79 75.26, -11.15 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.48, 136.12 APE9-dihe-in -129.13, 153.79 APE8-dihe-in -53.72, 121.31 APE8-rot-na 336.74 APE67-dihe-in -73.11, -30.35 -74.46, -30.93 APE12-dist-na 15.241 APE11-dist-na 10.575 APE10-dist-na 13.161 APE9-dist-in 6.928 None PTR394 PTR394 XRAY 2.6 0.18 0.265 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ack Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AD4A P06239 231 502 509.0 KBM:1 Type1 Active DFGin 6.67 14.738 BLAminus -138.55, 178.42 55.95, 86.04 -102.66, 22.41 294.12, 99.27 -58.94, -39.61 in-in in 8.418 Saltbr-in 3.133 HRD-in -98.32, -50.74 80.19, -7.43 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.34, 135.07 APE9-dihe-in -130.61, 154.41 APE8-dihe-in -64.7, 113.98 APE8-rot-na 336.56 APE67-dihe-in -73.67, -29.83 -58.57, -33.85 APE12-dist-na 15.395 APE11-dist-na 10.595 APE10-dist-na 13.218 APE9-dist-in 6.904 None PTR394 PTR394 XRAY 2.2 0.177 0.256 A 285 272 0 0 0 0 [[245, 496]] 1.0 3ad4 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AD5A P06239 230 502 509.0 5PB:1 Type1 Active DFGin 6.53 14.65 BLAminus -133.26, 179.48 56.65, 87.47 -103.27, 22.64 294.72, 94.2 -60.3, -39.81 in-in in 8.66 Saltbr-in 2.675 HRD-in -100.6, -52.09 78.06, -7.01 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.99, 138.23 APE9-dihe-in -134.82, 155.62 APE8-dihe-in -60.84, 123.2 APE8-rot-na 336.01 APE67-dihe-in -67.8, -24.85 -60.78, -43.22 APE12-dist-na 15.395 APE11-dist-na 10.722 APE10-dist-na 13.049 APE9-dist-in 6.803 None PTR394 PTR394 XRAY 2.0 0.161 0.218 A 285 273 0 0 0 0 [[245, 496]] 1.0 3ad5 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AD6A P06239 230 502 509.0 KSC:513 Type1 Active DFGin 6.606 14.617 BLAminus -137.3, 174.91 63.11, 87.06 -102.53, 22.84 293.54, 102.07 -62.24, -35.85 in-in in 8.597 Saltbr-in 2.946 HRD-in -96.19, -55.02 79.01, -5.26 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.04, 143.95 APE9-dihe-in -136.21, 160.1 APE8-dihe-in -66.15, 124.74 APE8-rot-na 332.64 APE67-dihe-in -70.22, -24.36 -63.01, -43.59 APE12-dist-na 15.086 APE11-dist-na 10.605 APE10-dist-na 13.282 APE9-dist-in 6.925 None PTR394 PTR394 XRAY 2.15 0.192 0.27 A 285 273 0 0 0 0 [[245, 496]] 1.0 3ad6 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3KXZA P06239 238 501 509.0 925:1 Type1 Active DFGin 6.268 13.796 BLAminus -141.81, -179.26 62.44, 72.38 -97.35, 29.16 312.06, 86.33 -58.6, -39.88 in-in in 8.273 Saltbr-in 3.384 HRD-in -90.63, -51.83 75.7, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.768 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.23, 135.78 APE9-dihe-in -129.65, 157.14 APE8-dihe-in -59.67, 101.6 APE8-rot-na 19.72 APE67-dihe-in -66.72, -21.47 -50.87, -46.22 APE12-dist-na 14.442 APE11-dist-na 9.801 APE10-dist-na 12.493 APE9-dist-in 6.682 None PTR394 PTR394 XRAY 2.37 0.195 0.261 A 287 264 0 0 0 0 [[245, 496]] 1.0 3kxz Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.465 14.181 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.418 Saltbr-in 2.843 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.294 APE10-dist-na 12.967 APE9-dist-in 6.951 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpd Homo sapiens TYR_LCK_HUMAN TYR 3.6e-93 317.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3BYMA P06239 230 501 509.0 AM0:1 Type1.5_Back Active DFGin 6.599 14.335 BLAminus -129.71, -173.8 43.96, 88.25 -99.71, 20.36 296.76, 99.13 -53.01, -42.28 in-in in 8.649 Saltbr-in 2.617 HRD-in -95.94, -50.0 73.2, -8.73 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.01, 147.55 APE9-dihe-in -139.76, 155.99 APE8-dihe-in -53.78, 113.22 APE8-rot-na 329.24 APE67-dihe-in -65.1, -24.46 -57.96, -45.81 APE12-dist-na 14.721 APE11-dist-na 10.03 APE10-dist-na 12.842 APE9-dist-in 6.945 None PTR394 PTR394 XRAY 2.0 0.226 0.274 A 272 272 0 0 0 0 [[245, 496]] 1.0 3bym Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.3 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3KMMA P06239 231 501 509.0 LHL:1 Type1.5_Back Active DFGin 6.863 14.83 BLAminus -127.6, -179.98 60.86, 89.79 -112.67, 27.22 299.87, 93.25 -61.87, -31.32 in-in in 8.698 Saltbr-in 3.056 HRD-in -91.14, -53.45 82.64, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.65, 152.15 APE9-dihe-in -136.18, 157.7 APE8-dihe-in -58.05, 115.06 APE8-rot-na 339.75 APE67-dihe-in -80.51, -24.68 -64.53, -28.52 APE12-dist-na 14.151 APE11-dist-na 9.71 APE10-dist-na 12.39 APE9-dist-in 6.629 Y505F PTR394 PTR394 XRAY 2.8 0.167 0.223 A 288 271 0 0 0 0 [[245, 496]] 1.0 3kmm Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3AC8A P06239 231 501 509.0 KSK:1 Type1 Inactive DFGin 6.16 14.296 BLAminus -149.31, -179.38 58.87, 71.98 -93.0, 13.95 295.99, 89.12 -55.97, -30.75 in-out in 7.614 Saltbr-out 4.721 HRD-in -95.71, -45.58 76.13, -14.85 out-in-in SNCoii in-in ActLoopNT-in 3.155 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.54, 135.63 APE9-dihe-in -130.81, 156.67 APE8-dihe-in -56.6, 115.07 APE8-rot-na 334.98 APE67-dihe-in -68.56, -21.46 -66.79, -40.68 APE12-dist-na 15.471 APE11-dist-na 10.744 APE10-dist-na 13.165 APE9-dist-in 6.893 None PTR394 PTR394 XRAY 2.3 0.229 0.318 A 285 271 0 0 0 0 [[245, 496]] 1.0 3ac8 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3B2WA P06239 238 500 509.0 9NH:601 Type1 Inactive DFGin 8.164 16.935 BLBminus -130.29, 174.3 30.22, 87.79 -64.26, 150.62 282.55, 10.68 -81.48, 131.12 in-in in 8.328 Saltbr-in 2.767 HRD-in -83.28, -59.73 86.44, -15.17 in-out-out SNCioo out-out ActLoopNT-out 10.517 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.56, -173.59 APE9-dihe-in -132.73, 178.81 APE8-dihe-in -73.78, 81.88 APE8-rot-na 335.17 APE67-dihe-in -55.0, -12.15 -34.45, -62.51 APE12-dist-na 14.669 APE11-dist-na 10.011 APE10-dist-na 12.66 APE9-dist-in 6.775 None None None XRAY 2.3 0.23 0.308 A 277 261 2 0 0 2 [[245, 496]] 1.0 3b2w Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3MPMA P06239 238 498 509.0 5LK:1 Type1 Inactive DFGin 4.0 14.518 BLBplus -117.53, 162.1 59.07, 39.27 -86.64, 152.74 45.5, 92.82 74.34, 9.15 in-in in 7.941 Saltbr-in 3.284 HRD-in -88.49, -65.37 87.18, -21.73 in-out-out SNCioo out-out ActLoopNT-out 9.227 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.26 APE8-dihe-out -60.9, 40.06 APE8-rot-na 23.67 APE67-dihe-in -68.02, -9.13 -55.59, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.884 D364N None None XRAY 1.95 0.172 0.213 A 267 257 4 0 0 4 [[245, 496]] 1.0 3mpm Homo sapiens TYR_LCK_HUMAN TYR 4.4e-94 320.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 4C3FA P06239 238 498 509.0 7KW:1499 Type1 Inactive DFGin 3.879 14.463 BLBplus -108.47, 162.66 60.18, 42.82 -97.37, 146.43 48.08, 83.58 82.78, 5.71 in-in in 8.014 Saltbr-in 3.073 HRD-in -84.53, -65.16 86.44, -20.06 in-out-out SNCioo out-out ActLoopNT-out 9.125 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.3 APE8-dihe-in -70.1, 116.34 APE8-rot-na 22.73 APE67-dihe-in -69.5, -8.96 -127.83, -9.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.897 D364N None None XRAY 1.72 0.18 0.22 A 267 257 4 0 0 4 [[245, 496]] 1.0 4c3f Homo sapiens TYR_LCK_HUMAN TYR 4.4e-94 320.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 6PDJA P06239 225 500 509.0 ODJ:60601 Type1.5_Front Inactive DFGout 11.351 8.956 BBAminus -108.06, 146.7 -118.62, 138.04 -125.67, 34.93 300.23, 95.6 96.65, -2.92 out-none out 17.115 Saltbr-none 999.0 HRD-in -91.73, -46.03 72.74, -1.78 none-in-in SNCnii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.11, 126.2 APE9-dihe-in -121.94, 158.33 APE8-dihe-in -71.45, 105.31 APE8-rot-na 23.06 APE67-dihe-in -61.4, -18.91 -48.25, -48.5 APE12-dist-na 15.007 APE11-dist-na 10.591 APE10-dist-na 12.887 APE9-dist-in 6.856 None PTR394 PTR394 XRAY 1.81 0.169 0.217 A 288 271 0 0 0 0 [[245, 496]] 1.0 6pdj Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OG8A P06239 237 499 509.0 1N8:60501 Type2 Inactive DFGout 13.881 10.992 BBAminus -146.02, -178.48 -159.06, 109.07 -91.7, -32.13 313.79, 133.51 123.25, 172.44 in-in in 7.535 Saltbr-in 2.555 HRD-in -72.68, -47.71 77.3, -17.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 90.85 APE8-rot-na 331.72 APE67-dihe-in -42.21, -25.74 -101.86, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 A 265 246 17 0 0 17 [[245, 496]] 1.0 2og8 Homo sapiens TYR_LCK_HUMAN TYR 1.1e-94 322.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OG8B P06239 237 499 509.0 1N8:60502 Type2 Inactive DFGout 13.773 11.422 BBAminus -151.29, 173.3 -150.55, 99.91 -84.69, -22.72 312.06, 114.32 85.84, -73.71 in-in in 7.891 Saltbr-in 2.73 HRD-in -73.85, -45.85 72.78, -12.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -121.15 APE8-rot-na 325.14 APE67-dihe-in -36.14, -21.79 -90.01, -51.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 B 265 247 16 0 0 16 [[245, 496]] 1.0 2og8 Homo sapiens TYR_LCK_HUMAN TYR 1.1e-94 322.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3BYSA P06239 230 501 509.0 AM5:1 Type2 Inactive DFGout 13.989 10.642 BBAminus -142.64, -177.35 -158.61, 106.94 -89.7, 9.59 310.93, 117.54 52.15, 70.11 in-in in 8.12 Saltbr-in 2.707 HRD-in -64.24, -46.91 79.98, -22.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.4 APE8-rot-na 312.02 APE67-dihe-out -44.95, -20.15 53.78, -66.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.246 0.284 A 277 255 17 0 0 17 [[245, 496]] 1.0 3bys Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 3BYUA P06239 231 501 509.0 AM6:1 Type2 Inactive DFGout 14.194 10.6 BBAminus -142.65, -178.45 -160.75, 101.5 -80.8, 5.51 308.08, 121.67 47.71, 62.39 in-in in 8.165 Saltbr-in 3.13 HRD-in -72.18, -47.4 76.26, -12.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioao APEdist_aaai APE10-dihe-none 999.0, 103.64 APE9-dihe-in -86.73, 103.84 APE8-dihe-out -31.76, 27.45 APE8-rot-na 312.67 APE67-dihe-out -39.72, -28.73 61.22, -78.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.331 APE9-dist-in 6.591 None None None XRAY 2.3 0.232 0.278 A 277 256 15 0 0 15 [[245, 496]] 1.0 3byu Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2PL0A P06239 231 498 509.0 STI:200 Type2 Inactive DFGout 13.439 10.98 BBAminus -123.86, 162.41 -130.4, 102.99 -85.25, -1.39 299.47, 139.85 60.55, 49.25 in-in in 8.109 Saltbr-in 2.891 HRD-in -103.3, -55.77 88.99, -24.94 in-out-in SNCioi out-in ActLoopNT-out 14.691 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.65, 127.24 APE9-dihe-in -162.32, 149.69 APE8-dihe-in -67.62, 110.43 APE8-rot-na 341.58 APE67-dihe-in -77.58, -4.79 -53.82, -46.7 APE12-dist-na 16.328 APE11-dist-na 13.494 APE10-dist-na 8.81 APE9-dist-in 5.888 None None None XRAY 2.8 0.215 0.261 A 289 268 0 0 0 0 [[245, 496]] 1.0 2pl0 Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OFVA P06239 232 498 509.0 242:60503 Type2 Inactive DFGout 14.725 10.522 None -150.8, 177.89 -156.14, 104.83 -146.7, 29.24 58.19, 94.86 -70.67, -18.76 in-in in 8.102 Saltbr-in 2.816 HRD-in -63.81, -56.73 81.39, -17.57 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -66.38, -9.13 999.0, 161.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 A 277 243 24 0 0 17 [[245, 496]] 1.0 2ofv Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK_HUMAN 2OFVB P06239 232 498 509.0 242:60503 Type2 Inactive DFGout 14.631 10.661 None -147.07, -175.72 -160.36, 105.8 -148.26, 28.72 55.51, 100.37 -69.36, -20.81 in-in in 7.938 Saltbr-in 2.797 HRD-in -66.99, -53.14 73.02, -17.06 in-out-none SNCion out-none ActLoopNT-out 11.867 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.76 APE8-rot-na 999.0 APE67-dihe-in -65.32, -16.12 -30.26, -66.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 B 277 243 24 0 0 11 [[245, 496]] 1.0 2ofv Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name