TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 39
Active chains: 27
Uniprot: LCK_HUMAN
Kinase Domain Residues: 245 - 496
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 71.8% AF-P06239-K1A
DFGout BBAminus 6 15.4% 6PDJA
DFGin BLBplus 2 5.1% 4C3FA
DFGout None 2 5.1% 2OFVA
DFGin BLBminus 1 2.6% 3B2WA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
LCK 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.6104 14.4162 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.7018 Saltbr-in 3.0957 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.9208 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.8556 APE11-dist-na 10.0047 APE10-dist-na 12.788 APE9-dist-in 6.7844 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpc TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK AF-P06239-K1A P06239 237 504 509.0 No_ligand No_ligand Active DFGin 6.328 14.1526 BLAminus -126.04, -170.13 45.11, 68.26 -81.31, 13.89 294.73, 92.3 -58.95, -32.04 in-in in 7.9598 Saltbr-in 2.6433 HRD-in -85.36, -45.83 65.94, -10.17 in-in-in SNCiii in-in ActLoopNT-in 2.8976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.19, 136.15 APE9-dihe-in -124.27, 155.23 APE8-dihe-in -71.92, 86.36 APE8-rot-na 31.24 APE67-dihe-in -69.87, -19.44 -40.13, -40.16 APE12-dist-na 14.8773 APE11-dist-na 10.0813 APE10-dist-na 12.4867 APE9-dist-in 6.7323 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[245, 496]] 1.0 AF-P06239-K1 TYR_LCK_HUMAN TYR 1.2e-94 322.4 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK AF-P06239-K3A P06239 237 504 509.0 No_ligand No_ligand Active DFGin 6.2935 13.7833 BLAminus -134.52, -177.41 60.79, 49.52 -69.07, 12.08 301.31, 98.31 -58.6, -28.96 in-in in 7.9756 Saltbr-in 2.772 HRD-in -89.57, -43.32 67.76, -6.71 in-in-in SNCiii in-in ActLoopNT-in 2.8754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.73, 134.23 APE9-dihe-in -125.84, 153.44 APE8-dihe-in -76.15, 84.49 APE8-rot-na 34.38 APE67-dihe-in -65.31, -15.47 -42.39, -42.12 APE12-dist-na 14.5862 APE11-dist-na 9.8547 APE10-dist-na 11.5566 APE9-dist-in 6.4588 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[245, 496]] 1.0 AF-P06239-K3 TYR_LCK_HUMAN TYR 1.2e-94 322.4 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3LCKA P06239 231 501 509.0 No_ligand No_ligand Active DFGin 6.4258 14.4717 BLAminus -138.47, 177.98 54.21, 81.26 -95.02, 22.59 299.7, 94.45 -60.07, -34.51 in-in in 8.8309 Saltbr-in 2.8215 HRD-in -102.22, -47.61 71.69, -2.05 in-in-in SNCiii in-in ActLoopNT-in 3.0015 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.94, 141.96 APE9-dihe-in -130.03, 160.62 APE8-dihe-in -57.18, 110.28 APE8-rot-na 333.88 APE67-dihe-in -69.85, -23.4 -57.11, -41.02 APE12-dist-na 14.8858 APE11-dist-na 10.2971 APE10-dist-na 13.0846 APE9-dist-in 6.9558 None PTR394 PTR394 XRAY 1.7 0.178 0.199 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 3lck TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OF2A P06239 231 501 509.0 547:201 Type1 Active DFGin 6.6047 14.2556 BLAminus -130.92, 179.58 52.61, 99.32 -112.12, 23.25 297.56, 95.88 -55.97, -39.1 in-in in 8.6335 Saltbr-in 3.4655 HRD-in -101.89, -47.47 69.94, -5.54 in-in-in SNCiii in-in ActLoopNT-in 2.8627 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.64, 147.2 APE9-dihe-in -135.37, 159.2 APE8-dihe-in -57.79, 111.53 APE8-rot-na 330.32 APE67-dihe-in -61.7, -24.35 -53.57, -49.18 APE12-dist-na 14.7772 APE11-dist-na 10.0622 APE10-dist-na 12.7946 APE9-dist-in 6.8651 None None None XRAY 2.0 0.26 0.261 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 2of2 TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OF4A P06239 231 501 509.0 979:101 Type1 Active DFGin 6.5453 14.232 BLAminus -133.06, -178.99 53.91, 89.2 -103.35, 22.83 299.69, 97.75 -57.7, -37.49 in-in in 8.7642 Saltbr-in 3.1834 HRD-in -98.49, -49.04 70.92, -5.33 in-in-in SNCiii in-in ActLoopNT-in 2.8434 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.02, 146.22 APE9-dihe-in -134.68, 159.17 APE8-dihe-in -56.47, 112.93 APE8-rot-na 328.85 APE67-dihe-in -61.04, -24.72 -55.46, -48.9 APE12-dist-na 14.7824 APE11-dist-na 10.0899 APE10-dist-na 12.8092 APE9-dist-in 6.8689 None None None XRAY 2.7 0.264 0.296 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 2of4 TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3BYOA P06239 231 501 509.0 AM9:1 Type1 Active DFGin 6.6087 14.9514 BLAminus -136.92, 176.33 55.13, 85.04 -99.79, 29.59 302.99, 91.68 -59.79, -37.93 in-in in 8.7078 Saltbr-in 2.9407 HRD-in -96.3, -48.46 72.8, -7.81 in-in-in SNCiii in-in ActLoopNT-in 2.9999 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.12, 144.98 APE9-dihe-in -137.68, 156.29 APE8-dihe-in -54.73, 116.01 APE8-rot-na 327.73 APE67-dihe-in -62.67, -24.49 -60.49, -48.08 APE12-dist-na 14.6198 APE11-dist-na 9.9187 APE10-dist-na 12.7209 APE9-dist-in 7.0114 None PTR394 PTR394 XRAY 2.0 0.223 0.259 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 3byo TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OFUA P06239 229 501 509.0 1N9:1 Type1 Active DFGin 6.718 14.5593 BLAminus -128.56, 176.04 58.95, 81.99 -93.53, 23.85 301.51, 96.63 -54.11, -42.18 in-in in 9.1958 Saltbr-in 2.9788 HRD-in -97.82, -52.73 71.18, -1.53 in-in-in SNCiii in-in ActLoopNT-in 3.0126 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.05, 145.38 APE9-dihe-in -130.84, 159.88 APE8-dihe-in -58.11, 117.32 APE8-rot-na 329.61 APE67-dihe-in -64.49, -21.74 -57.73, -49.99 APE12-dist-na 14.4598 APE11-dist-na 9.7105 APE10-dist-na 12.7495 APE9-dist-in 6.878 None PTR394 PTR394 XRAY 2.0 0.228 0.291 A 273.0 273.0 0 29 29 0 [[245, 496]] 1.0 2ofu TYR_LCK_HUMAN TYR 1.3e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 1QPEA P06239 231 501 509.0 PP2:1904 Type1 Active DFGin 6.3909 14.3133 BLAminus -142.96, -179.55 55.35, 67.52 -84.73, 15.63 297.65, 101.73 -55.95, -34.43 in-in in 8.0231 Saltbr-in 2.6918 HRD-in -108.83, -49.35 72.69, 1.82 in-in-in SNCiii in-in ActLoopNT-in 2.9998 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.37, 142.25 APE9-dihe-in -130.54, 154.89 APE8-dihe-in -61.74, 112.03 APE8-rot-na 337.13 APE67-dihe-in -65.74, -24.28 -52.69, -45.66 APE12-dist-na 14.9264 APE11-dist-na 10.3055 APE10-dist-na 13.0188 APE9-dist-in 6.8701 None PTR394 PTR394 XRAY 2.0 0.189 0.254 A 279.0 271.0 0 29 29 0 [[245, 496]] 1.0 1qpe TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.6673 13.9099 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.1293 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.7028 APE11-dist-na 10.0918 APE10-dist-na 12.9477 APE9-dist-in 7.0162 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279.0 266.0 0 29 29 0 [[245, 496]] 1.0 1qpj TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.4993 14.1929 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.5119 Saltbr-in 2.9335 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.1006 APE11-dist-na 10.3495 APE10-dist-na 13.0138 APE9-dist-in 6.8223 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zm1 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2ZM4A P06239 231 501 509.0 KSM:604 Type1 Active DFGin 6.6365 14.9001 BLAminus -125.54, 175.78 59.89, 100.94 -115.94, 31.54 296.17, 83.88 -61.97, -35.07 in-in in 8.6427 Saltbr-in 2.3412 HRD-in -94.46, -53.83 75.78, 0.2 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.7, 135.77 APE9-dihe-in -125.01, 150.02 APE8-dihe-in -43.28, 122.59 APE8-rot-na 354.44 APE67-dihe-in -80.95, -19.91 -67.13, -31.95 APE12-dist-na 15.349 APE11-dist-na 11.187 APE10-dist-na 13.3719 APE9-dist-in 6.9312 None PTR394 PTR394 XRAY 2.7 0.186 0.274 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zm4 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2ZYBA P06239 231 501 509.0 KSL:511 Type1 Active DFGin 6.36 13.8544 BLAminus -123.29, -162.69 28.22, 106.2 -121.14, 30.74 300.5, 99.58 -53.55, -45.23 in-in in 8.3133 Saltbr-in 2.7512 HRD-in -88.81, -51.29 76.39, -10.36 in-in-in SNCiii in-in ActLoopNT-in 2.9333 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.01, 133.28 APE9-dihe-in -125.32, 152.97 APE8-dihe-in -51.44, 112.14 APE8-rot-na 336.6 APE67-dihe-in -70.07, -21.44 -63.76, -36.56 APE12-dist-na 15.2058 APE11-dist-na 10.6866 APE10-dist-na 13.2843 APE9-dist-in 6.9205 None PTR394 PTR394 XRAY 2.55 0.183 0.291 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zyb TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AC1A P06239 231 502 509.0 KZI:514 Type1 Active DFGin 6.4874 14.5417 BLAminus -131.48, -179.03 55.28, 80.68 -95.73, 16.37 295.17, 96.65 -60.65, -33.27 in-in in 8.4917 Saltbr-in 2.8277 HRD-in -98.47, -48.35 73.68, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.9962 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.39, 135.48 APE9-dihe-in -130.85, 154.91 APE8-dihe-in -61.35, 117.59 APE8-rot-na 336.87 APE67-dihe-in -69.89, -26.11 -63.6, -40.28 APE12-dist-na 15.212 APE11-dist-na 10.5248 APE10-dist-na 12.943 APE9-dist-in 6.9436 None PTR394 PTR394 XRAY 1.99 0.161 0.221 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac1 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AC2A P06239 231 502 509.0 KSE:514 Type1 Active DFGin 6.6055 14.5653 BLAminus -135.84, 168.64 64.15, 84.09 -100.36, 19.65 294.74, 98.08 -57.49, -38.24 in-in in 8.6685 Saltbr-in 3.3397 HRD-in -100.58, -48.65 73.34, -4.91 in-in-in SNCiii in-in ActLoopNT-in 2.9031 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 139.12 APE9-dihe-in -135.6, 152.46 APE8-dihe-in -59.2, 122.81 APE8-rot-na 332.56 APE67-dihe-in -68.23, -28.88 -61.81, -41.57 APE12-dist-na 15.2632 APE11-dist-na 10.5795 APE10-dist-na 13.0208 APE9-dist-in 6.8692 None PTR394 PTR394 XRAY 2.1 0.164 0.225 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac2 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AC3A P06239 231 502 509.0 KSH:511 Type1 Active DFGin 6.4587 14.6307 BLAminus -147.21, 174.45 54.99, 89.06 -104.08, 27.27 302.45, 83.28 -58.22, -33.73 in-in in 8.5524 Saltbr-in 2.7449 HRD-in -111.81, -47.37 77.05, -14.83 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.99, 144.35 APE9-dihe-in -134.94, 154.73 APE8-dihe-in -49.27, 117.05 APE8-rot-na 333.21 APE67-dihe-in -65.53, -31.62 -66.91, -37.94 APE12-dist-na 15.2721 APE11-dist-na 10.707 APE10-dist-na 13.3294 APE9-dist-in 6.9376 None PTR394 PTR394 XRAY 2.55 0.209 0.274 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac3 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AC4A P06239 231 502 509.0 KZL:513 Type1 Active DFGin 6.5609 14.9641 BLAminus -134.05, 169.16 63.4, 83.38 -101.46, 27.47 299.41, 85.84 -61.03, -40.36 in-in in 8.6233 Saltbr-in 2.849 HRD-in -99.06, -47.22 74.57, -0.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.44, 142.47 APE9-dihe-in -122.94, 163.65 APE8-dihe-in -61.25, 115.38 APE8-rot-na 337.67 APE67-dihe-in -59.59, -35.92 -64.0, -44.24 APE12-dist-na 15.1738 APE11-dist-na 10.3539 APE10-dist-na 13.4191 APE9-dist-in 7.0638 None PTR394 PTR394 XRAY 2.7 0.211 0.283 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac4 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AC5A P06239 231 502 509.0 KZM:513 Type1 Active DFGin 6.352 13.8552 BLAminus -139.87, -178.59 59.74, 72.52 -92.79, 17.42 308.98, 89.37 -47.63, -35.76 in-in in 8.4029 Saltbr-in 3.207 HRD-in -107.79, -48.48 77.33, -8.64 in-in-in SNCiii in-in ActLoopNT-in 3.1306 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.67, 143.58 APE9-dihe-in -137.14, 147.29 APE8-dihe-in -52.03, 120.11 APE8-rot-na 337.78 APE67-dihe-in -80.56, -23.87 -69.56, -26.75 APE12-dist-na 15.3675 APE11-dist-na 10.6806 APE10-dist-na 12.8971 APE9-dist-in 6.8392 None PTR394 PTR394 XRAY 2.5 0.171 0.268 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac5 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3ACJA P06239 231 502 509.0 KSS:513 Type1 Active DFGin 6.4972 14.5524 BLAminus -135.95, -178.35 54.49, 81.98 -96.02, 16.9 296.03, 99.25 -59.02, -33.73 in-in in 8.4812 Saltbr-in 2.7335 HRD-in -98.9, -46.49 67.28, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.9428 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.6, 139.05 APE9-dihe-in -134.1, 152.03 APE8-dihe-in -62.65, 126.38 APE8-rot-na 332.51 APE67-dihe-in -67.23, -30.82 -66.13, -39.51 APE12-dist-na 15.3445 APE11-dist-na 10.6097 APE10-dist-na 12.9594 APE9-dist-in 6.8294 None PTR394 PTR394 XRAY 2.2 0.175 0.247 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3acj TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3ACKA P06239 231 502 509.0 KSR:1 Type1 Active DFGin 6.486 14.5539 BLAminus -138.87, 177.35 61.26, 86.12 -103.64, 22.65 299.89, 92.45 -53.76, -45.12 in-in in 8.4365 Saltbr-in 2.7831 HRD-in -99.63, -48.79 75.26, -11.15 in-in-in SNCiii in-in ActLoopNT-in 2.9293 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.48, 136.12 APE9-dihe-in -129.13, 153.79 APE8-dihe-in -53.72, 121.31 APE8-rot-na 336.74 APE67-dihe-in -73.11, -30.35 -74.46, -30.93 APE12-dist-na 15.2411 APE11-dist-na 10.5753 APE10-dist-na 13.1606 APE9-dist-in 6.9279 None PTR394 PTR394 XRAY 2.6 0.18 0.265 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ack TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AD4A P06239 231 502 509.0 KBM:1 Type1 Active DFGin 6.6698 14.7383 BLAminus -138.55, 178.42 55.95, 86.04 -102.66, 22.41 294.12, 99.27 -58.94, -39.61 in-in in 8.418 Saltbr-in 3.1333 HRD-in -98.32, -50.74 80.19, -7.43 in-in-in SNCiii in-in ActLoopNT-in 3.0071 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.34, 135.07 APE9-dihe-in -130.61, 154.41 APE8-dihe-in -64.7, 113.98 APE8-rot-na 336.56 APE67-dihe-in -73.67, -29.83 -58.57, -33.85 APE12-dist-na 15.3949 APE11-dist-na 10.5945 APE10-dist-na 13.2177 APE9-dist-in 6.9036 None PTR394 PTR394 XRAY 2.2 0.177 0.256 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ad4 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AD5A P06239 230 502 509.0 5PB:1 Type1 Active DFGin 6.53 14.65 BLAminus -133.26, 179.48 56.65, 87.47 -103.27, 22.64 294.72, 94.2 -60.3, -39.81 in-in in 8.6599 Saltbr-in 2.6752 HRD-in -100.6, -52.09 78.06, -7.01 in-in-in SNCiii in-in ActLoopNT-in 2.8767 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.99, 138.23 APE9-dihe-in -134.82, 155.62 APE8-dihe-in -60.84, 123.2 APE8-rot-na 336.01 APE67-dihe-in -67.8, -24.85 -60.78, -43.22 APE12-dist-na 15.3948 APE11-dist-na 10.7224 APE10-dist-na 13.0487 APE9-dist-in 6.8034 None PTR394 PTR394 XRAY 2.0 0.161 0.218 A 285.0 273.0 0 29 29 0 [[245, 496]] 1.0 3ad5 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AD6A P06239 230 502 509.0 KSC:513 Type1 Active DFGin 6.6063 14.6171 BLAminus -137.3, 174.91 63.11, 87.06 -102.53, 22.84 293.54, 102.07 -62.24, -35.85 in-in in 8.5974 Saltbr-in 2.9461 HRD-in -96.19, -55.02 79.01, -5.26 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.04, 143.95 APE9-dihe-in -136.21, 160.1 APE8-dihe-in -66.15, 124.74 APE8-rot-na 332.64 APE67-dihe-in -70.22, -24.36 -63.01, -43.59 APE12-dist-na 15.0858 APE11-dist-na 10.6055 APE10-dist-na 13.282 APE9-dist-in 6.9252 None PTR394 PTR394 XRAY 2.15 0.192 0.27 A 285.0 273.0 0 29 29 0 [[245, 496]] 1.0 3ad6 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3KXZA P06239 238 501 509.0 925:1 Type1 Active DFGin 6.2682 13.7963 BLAminus -141.81, -179.26 62.44, 72.38 -97.35, 29.16 312.06, 86.33 -58.6, -39.88 in-in in 8.2727 Saltbr-in 3.384 HRD-in -90.63, -51.83 75.7, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.7679 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.23, 135.78 APE9-dihe-in -129.65, 157.14 APE8-dihe-in -59.67, 101.6 APE8-rot-na 19.72 APE67-dihe-in -66.72, -21.47 -50.87, -46.22 APE12-dist-na 14.4422 APE11-dist-na 9.8007 APE10-dist-na 12.4931 APE9-dist-in 6.6817 None PTR394 PTR394 XRAY 2.37 0.195 0.261 A 287.0 264.0 0 29 29 0 [[245, 496]] 1.0 3kxz TYR_LCK_HUMAN TYR 1.5e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.4653 14.1815 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.4176 Saltbr-in 2.8434 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.9762 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.2937 APE10-dist-na 12.9671 APE9-dist-in 6.9506 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpd TYR_LCK_HUMAN TYR 3.6e-93 317.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3BYMA P06239 230 501 509.0 AM0:1 Type1.5_Back Active DFGin 6.5992 14.335 BLAminus -129.71, -173.8 43.96, 88.25 -99.71, 20.36 296.76, 99.13 -53.01, -42.28 in-in in 8.6491 Saltbr-in 2.6173 HRD-in -95.94, -50.0 73.2, -8.73 in-in-in SNCiii in-in ActLoopNT-in 2.9487 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.01, 147.55 APE9-dihe-in -139.76, 155.99 APE8-dihe-in -53.78, 113.22 APE8-rot-na 329.24 APE67-dihe-in -65.1, -24.46 -57.96, -45.81 APE12-dist-na 14.721 APE11-dist-na 10.0295 APE10-dist-na 12.8419 APE9-dist-in 6.9447 None PTR394 PTR394 XRAY 2.0 0.226 0.274 A 272.0 272.0 0 29 29 0 [[245, 496]] 1.0 3bym TYR_LCK_HUMAN TYR 1.3e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3KMMA P06239 231 501 509.0 LHL:1 Type1.5_Back Active DFGin 6.8628 14.8299 BLAminus -127.6, -179.98 60.86, 89.79 -112.67, 27.22 299.87, 93.25 -61.87, -31.32 in-in in 8.6985 Saltbr-in 3.0559 HRD-in -91.14, -53.45 82.64, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.8642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.65, 152.15 APE9-dihe-in -136.18, 157.7 APE8-dihe-in -58.05, 115.06 APE8-rot-na 339.75 APE67-dihe-in -80.51, -24.68 -64.53, -28.52 APE12-dist-na 14.1508 APE11-dist-na 9.7097 APE10-dist-na 12.3903 APE9-dist-in 6.6287 Y505F PTR394 PTR394 XRAY 2.8 0.167 0.223 A 288.0 271.0 0 29 29 0 [[245, 496]] 1.0 3kmm TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3AC8A P06239 231 501 509.0 KSK:1 Type1 Inactive DFGin 6.1602 14.2955 BLAminus -149.31, -179.38 58.87, 71.98 -93.0, 13.95 295.99, 89.12 -55.97, -30.75 in-out in 7.6137 Saltbr-out 4.721 HRD-in -95.71, -45.58 76.13, -14.85 out-in-in SNCoii in-in ActLoopNT-in 3.1553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.54, 135.63 APE9-dihe-in -130.81, 156.67 APE8-dihe-in -56.6, 115.07 APE8-rot-na 334.98 APE67-dihe-in -68.56, -21.46 -66.79, -40.68 APE12-dist-na 15.4712 APE11-dist-na 10.7439 APE10-dist-na 13.1651 APE9-dist-in 6.8929 None PTR394 PTR394 XRAY 2.3 0.229 0.318 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 3ac8 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3B2WA P06239 238 500 509.0 9NH:601 Type1 Inactive DFGin 8.1642 16.9346 BLBminus -130.29, 174.3 30.22, 87.79 -64.26, 150.62 282.55, 10.68 -81.48, 131.12 in-in in 8.328 Saltbr-in 2.7673 HRD-in -83.28, -59.73 86.44, -15.17 in-out-out SNCioo out-out ActLoopNT-out 10.5165 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.56, -173.59 APE9-dihe-in -132.73, 178.81 APE8-dihe-in -73.78, 81.88 APE8-rot-na 335.17 APE67-dihe-in -55.0, -12.15 -34.45, -62.51 APE12-dist-na 14.6694 APE11-dist-na 10.0108 APE10-dist-na 12.6603 APE9-dist-in 6.7753 None None None XRAY 2.3 0.23 0.308 A 277.0 261.0 2 29 27 2 [[245, 496]] 1.0 3b2w TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3MPMA P06239 238 498 509.0 5LK:1 Type1 Inactive DFGin 4.0001 14.5184 BLBplus -117.53, 162.1 59.07, 39.27 -86.64, 152.74 45.5, 92.82 74.34, 9.15 in-in in 7.9413 Saltbr-in 3.2839 HRD-in -88.49, -65.37 87.18, -21.73 in-out-out SNCioo out-out ActLoopNT-out 9.2274 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.26 APE8-dihe-out -60.9, 40.06 APE8-rot-na 23.67 APE67-dihe-in -68.02, -9.13 -55.59, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.884 D364N None None XRAY 1.95 0.172 0.213 A 267.0 257.0 4 29 25 4 [[245, 496]] 1.0 3mpm TYR_LCK_HUMAN TYR 4.4e-94 320.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 4C3FA P06239 238 498 509.0 7KW:1499 Type1 Inactive DFGin 3.8792 14.4626 BLBplus -108.47, 162.66 60.18, 42.82 -97.37, 146.43 48.08, 83.58 82.78, 5.71 in-in in 8.0144 Saltbr-in 3.073 HRD-in -84.53, -65.16 86.44, -20.06 in-out-out SNCioo out-out ActLoopNT-out 9.1246 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.3 APE8-dihe-in -70.1, 116.34 APE8-rot-na 22.73 APE67-dihe-in -69.5, -8.96 -127.83, -9.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8973 D364N None None XRAY 1.72 0.18 0.22 A 267.0 257.0 4 29 25 4 [[245, 496]] 1.0 4c3f TYR_LCK_HUMAN TYR 4.4e-94 320.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 6PDJA P06239 225 500 509.0 ODJ:60601 Type1.5_Front Inactive DFGout 11.3506 8.9556 BBAminus -108.06, 146.7 -118.62, 138.04 -125.67, 34.93 300.23, 95.6 96.65, -2.92 out-none out 17.1148 Saltbr-none 999.0 HRD-in -91.73, -46.03 72.74, -1.78 none-in-in SNCnii in-in ActLoopNT-in 2.9016 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.11, 126.2 APE9-dihe-in -121.94, 158.33 APE8-dihe-in -71.45, 105.31 APE8-rot-na 23.06 APE67-dihe-in -61.4, -18.91 -48.25, -48.5 APE12-dist-na 15.0074 APE11-dist-na 10.5909 APE10-dist-na 12.8875 APE9-dist-in 6.8558 None PTR394 PTR394 XRAY 1.81 0.169 0.217 A 288.0 271.0 0 29 29 0 [[245, 496]] 1.0 6pdj TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OG8A P06239 237 499 509.0 1N8:60501 Type2 Inactive DFGout 13.8808 10.9925 BBAminus -146.02, -178.48 -159.06, 109.07 -91.7, -32.13 313.79, 133.51 123.25, 172.44 in-in in 7.5355 Saltbr-in 2.5546 HRD-in -72.68, -47.71 77.3, -17.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 90.85 APE8-rot-na 331.72 APE67-dihe-in -42.21, -25.74 -101.86, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 A 265.0 246.0 17 29 12 17 [[245, 496]] 1.0 2og8 TYR_LCK_HUMAN TYR 1.1e-94 322.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OG8B P06239 237 499 509.0 1N8:60502 Type2 Inactive DFGout 13.7734 11.422 BBAminus -151.29, 173.3 -150.55, 99.91 -84.69, -22.72 312.06, 114.32 85.84, -73.71 in-in in 7.891 Saltbr-in 2.7303 HRD-in -73.85, -45.85 72.78, -12.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -121.15 APE8-rot-na 325.14 APE67-dihe-in -36.14, -21.79 -90.01, -51.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 B 265.0 247.0 16 29 13 16 [[245, 496]] 1.0 2og8 TYR_LCK_HUMAN TYR 1.1e-94 322.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3BYSA P06239 230 501 509.0 AM5:1 Type2 Inactive DFGout 13.9888 10.6423 BBAminus -142.64, -177.35 -158.61, 106.94 -89.7, 9.59 310.93, 117.54 52.15, 70.11 in-in in 8.12 Saltbr-in 2.7074 HRD-in -64.24, -46.91 79.98, -22.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.4 APE8-rot-na 312.02 APE67-dihe-out -44.95, -20.15 53.78, -66.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.246 0.284 A 277.0 255.0 17 29 12 17 [[245, 496]] 1.0 3bys TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 3BYUA P06239 231 501 509.0 AM6:1 Type2 Inactive DFGout 14.194 10.6001 BBAminus -142.65, -178.45 -160.75, 101.5 -80.8, 5.51 308.08, 121.67 47.71, 62.39 in-in in 8.1652 Saltbr-in 3.1302 HRD-in -72.18, -47.4 76.26, -12.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioao APEdist_aaai APE10-dihe-none 999.0, 103.64 APE9-dihe-in -86.73, 103.84 APE8-dihe-out -31.76, 27.45 APE8-rot-na 312.67 APE67-dihe-out -39.72, -28.73 61.22, -78.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.3313 APE9-dist-in 6.5914 None None None XRAY 2.3 0.232 0.278 A 277.0 256.0 15 29 14 15 [[245, 496]] 1.0 3byu TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2PL0A P06239 231 498 509.0 STI:200 Type2 Inactive DFGout 13.4391 10.9797 BBAminus -123.86, 162.41 -130.4, 102.99 -85.25, -1.39 299.47, 139.85 60.55, 49.25 in-in in 8.1088 Saltbr-in 2.891 HRD-in -103.3, -55.77 88.99, -24.94 in-out-in SNCioi out-in ActLoopNT-out 14.6912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.65, 127.24 APE9-dihe-in -162.32, 149.69 APE8-dihe-in -67.62, 110.43 APE8-rot-na 341.58 APE67-dihe-in -77.58, -4.79 -53.82, -46.7 APE12-dist-na 16.3279 APE11-dist-na 13.4942 APE10-dist-na 8.8097 APE9-dist-in 5.8879 None None None XRAY 2.8 0.215 0.261 A 289.0 268.0 0 29 29 0 [[245, 496]] 1.0 2pl0 TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OFVA P06239 232 498 509.0 242:60503 Type2 Inactive DFGout 14.7252 10.522 None -150.8, 177.89 -156.14, 104.83 -146.7, 29.24 58.19, 94.86 -70.67, -18.76 in-in in 8.1017 Saltbr-in 2.8157 HRD-in -63.81, -56.73 81.39, -17.57 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -66.38, -9.13 999.0, 161.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 A 277.0 243.0 24 29 12 17 [[245, 496]] 1.0 2ofv TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK 2OFVB P06239 232 498 509.0 242:60503 Type2 Inactive DFGout 14.6309 10.6606 None -147.07, -175.72 -160.36, 105.8 -148.26, 28.72 55.51, 100.37 -69.36, -20.81 in-in in 7.9375 Saltbr-in 2.7974 HRD-in -66.99, -53.14 73.02, -17.06 in-out-none SNCion out-none ActLoopNT-out 11.8667 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.76 APE8-rot-na 999.0 APE67-dihe-in -65.32, -16.12 -30.26, -66.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 B 277.0 243.0 24 29 18 11 [[245, 496]] 1.0 2ofv TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 39
Active chains: 27
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 71.8% AF-P06239-K1A
DFGout BBAminus 6 15.4% 6PDJA
DFGin BLBplus 2 5.1% 4C3FA
DFGout None 2 5.1% 2OFVA
DFGin BLBminus 1 2.6% 3B2WA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
LCK LCK_HUMAN 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.6104 14.4162 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.7018 Saltbr-in 3.0957 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.9208 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.8556 APE11-dist-na 10.0047 APE10-dist-na 12.788 APE9-dist-in 6.7844 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpc Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN AF-P06239-K1A P06239 237 504 509.0 No_ligand No_ligand Active DFGin 6.328 14.1526 BLAminus -126.04, -170.13 45.11, 68.26 -81.31, 13.89 294.73, 92.3 -58.95, -32.04 in-in in 7.9598 Saltbr-in 2.6433 HRD-in -85.36, -45.83 65.94, -10.17 in-in-in SNCiii in-in ActLoopNT-in 2.8976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.19, 136.15 APE9-dihe-in -124.27, 155.23 APE8-dihe-in -71.92, 86.36 APE8-rot-na 31.24 APE67-dihe-in -69.87, -19.44 -40.13, -40.16 APE12-dist-na 14.8773 APE11-dist-na 10.0813 APE10-dist-na 12.4867 APE9-dist-in 6.7323 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[245, 496]] 1.0 AF-P06239-K1 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.4 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN AF-P06239-K3A P06239 237 504 509.0 No_ligand No_ligand Active DFGin 6.2935 13.7833 BLAminus -134.52, -177.41 60.79, 49.52 -69.07, 12.08 301.31, 98.31 -58.6, -28.96 in-in in 7.9756 Saltbr-in 2.772 HRD-in -89.57, -43.32 67.76, -6.71 in-in-in SNCiii in-in ActLoopNT-in 2.8754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.73, 134.23 APE9-dihe-in -125.84, 153.44 APE8-dihe-in -76.15, 84.49 APE8-rot-na 34.38 APE67-dihe-in -65.31, -15.47 -42.39, -42.12 APE12-dist-na 14.5862 APE11-dist-na 9.8547 APE10-dist-na 11.5566 APE9-dist-in 6.4588 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 29 29 0 [[245, 496]] 1.0 AF-P06239-K3 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.4 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3LCKA P06239 231 501 509.0 No_ligand No_ligand Active DFGin 6.4258 14.4717 BLAminus -138.47, 177.98 54.21, 81.26 -95.02, 22.59 299.7, 94.45 -60.07, -34.51 in-in in 8.8309 Saltbr-in 2.8215 HRD-in -102.22, -47.61 71.69, -2.05 in-in-in SNCiii in-in ActLoopNT-in 3.0015 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.94, 141.96 APE9-dihe-in -130.03, 160.62 APE8-dihe-in -57.18, 110.28 APE8-rot-na 333.88 APE67-dihe-in -69.85, -23.4 -57.11, -41.02 APE12-dist-na 14.8858 APE11-dist-na 10.2971 APE10-dist-na 13.0846 APE9-dist-in 6.9558 None PTR394 PTR394 XRAY 1.7 0.178 0.199 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 3lck Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OF2A P06239 231 501 509.0 547:201 Type1 Active DFGin 6.6047 14.2556 BLAminus -130.92, 179.58 52.61, 99.32 -112.12, 23.25 297.56, 95.88 -55.97, -39.1 in-in in 8.6335 Saltbr-in 3.4655 HRD-in -101.89, -47.47 69.94, -5.54 in-in-in SNCiii in-in ActLoopNT-in 2.8627 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.64, 147.2 APE9-dihe-in -135.37, 159.2 APE8-dihe-in -57.79, 111.53 APE8-rot-na 330.32 APE67-dihe-in -61.7, -24.35 -53.57, -49.18 APE12-dist-na 14.7772 APE11-dist-na 10.0622 APE10-dist-na 12.7946 APE9-dist-in 6.8651 None None None XRAY 2.0 0.26 0.261 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 2of2 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OF4A P06239 231 501 509.0 979:101 Type1 Active DFGin 6.5453 14.232 BLAminus -133.06, -178.99 53.91, 89.2 -103.35, 22.83 299.69, 97.75 -57.7, -37.49 in-in in 8.7642 Saltbr-in 3.1834 HRD-in -98.49, -49.04 70.92, -5.33 in-in-in SNCiii in-in ActLoopNT-in 2.8434 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.02, 146.22 APE9-dihe-in -134.68, 159.17 APE8-dihe-in -56.47, 112.93 APE8-rot-na 328.85 APE67-dihe-in -61.04, -24.72 -55.46, -48.9 APE12-dist-na 14.7824 APE11-dist-na 10.0899 APE10-dist-na 12.8092 APE9-dist-in 6.8689 None None None XRAY 2.7 0.264 0.296 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 2of4 Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3BYOA P06239 231 501 509.0 AM9:1 Type1 Active DFGin 6.6087 14.9514 BLAminus -136.92, 176.33 55.13, 85.04 -99.79, 29.59 302.99, 91.68 -59.79, -37.93 in-in in 8.7078 Saltbr-in 2.9407 HRD-in -96.3, -48.46 72.8, -7.81 in-in-in SNCiii in-in ActLoopNT-in 2.9999 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.12, 144.98 APE9-dihe-in -137.68, 156.29 APE8-dihe-in -54.73, 116.01 APE8-rot-na 327.73 APE67-dihe-in -62.67, -24.49 -60.49, -48.08 APE12-dist-na 14.6198 APE11-dist-na 9.9187 APE10-dist-na 12.7209 APE9-dist-in 7.0114 None PTR394 PTR394 XRAY 2.0 0.223 0.259 A 271.0 271.0 0 29 29 0 [[245, 496]] 1.0 3byo Homo sapiens TYR_LCK_HUMAN TYR 1.2e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OFUA P06239 229 501 509.0 1N9:1 Type1 Active DFGin 6.718 14.5593 BLAminus -128.56, 176.04 58.95, 81.99 -93.53, 23.85 301.51, 96.63 -54.11, -42.18 in-in in 9.1958 Saltbr-in 2.9788 HRD-in -97.82, -52.73 71.18, -1.53 in-in-in SNCiii in-in ActLoopNT-in 3.0126 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.05, 145.38 APE9-dihe-in -130.84, 159.88 APE8-dihe-in -58.11, 117.32 APE8-rot-na 329.61 APE67-dihe-in -64.49, -21.74 -57.73, -49.99 APE12-dist-na 14.4598 APE11-dist-na 9.7105 APE10-dist-na 12.7495 APE9-dist-in 6.878 None PTR394 PTR394 XRAY 2.0 0.228 0.291 A 273.0 273.0 0 29 29 0 [[245, 496]] 1.0 2ofu Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 1QPEA P06239 231 501 509.0 PP2:1904 Type1 Active DFGin 6.3909 14.3133 BLAminus -142.96, -179.55 55.35, 67.52 -84.73, 15.63 297.65, 101.73 -55.95, -34.43 in-in in 8.0231 Saltbr-in 2.6918 HRD-in -108.83, -49.35 72.69, 1.82 in-in-in SNCiii in-in ActLoopNT-in 2.9998 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.37, 142.25 APE9-dihe-in -130.54, 154.89 APE8-dihe-in -61.74, 112.03 APE8-rot-na 337.13 APE67-dihe-in -65.74, -24.28 -52.69, -45.66 APE12-dist-na 14.9264 APE11-dist-na 10.3055 APE10-dist-na 13.0188 APE9-dist-in 6.8701 None PTR394 PTR394 XRAY 2.0 0.189 0.254 A 279.0 271.0 0 29 29 0 [[245, 496]] 1.0 1qpe Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.6673 13.9099 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.1293 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.7028 APE11-dist-na 10.0918 APE10-dist-na 12.9477 APE9-dist-in 7.0162 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279.0 266.0 0 29 29 0 [[245, 496]] 1.0 1qpj Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.4993 14.1929 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.5119 Saltbr-in 2.9335 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.1006 APE11-dist-na 10.3495 APE10-dist-na 13.0138 APE9-dist-in 6.8223 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zm1 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2ZM4A P06239 231 501 509.0 KSM:604 Type1 Active DFGin 6.6365 14.9001 BLAminus -125.54, 175.78 59.89, 100.94 -115.94, 31.54 296.17, 83.88 -61.97, -35.07 in-in in 8.6427 Saltbr-in 2.3412 HRD-in -94.46, -53.83 75.78, 0.2 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.7, 135.77 APE9-dihe-in -125.01, 150.02 APE8-dihe-in -43.28, 122.59 APE8-rot-na 354.44 APE67-dihe-in -80.95, -19.91 -67.13, -31.95 APE12-dist-na 15.349 APE11-dist-na 11.187 APE10-dist-na 13.3719 APE9-dist-in 6.9312 None PTR394 PTR394 XRAY 2.7 0.186 0.274 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zm4 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2ZYBA P06239 231 501 509.0 KSL:511 Type1 Active DFGin 6.36 13.8544 BLAminus -123.29, -162.69 28.22, 106.2 -121.14, 30.74 300.5, 99.58 -53.55, -45.23 in-in in 8.3133 Saltbr-in 2.7512 HRD-in -88.81, -51.29 76.39, -10.36 in-in-in SNCiii in-in ActLoopNT-in 2.9333 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.01, 133.28 APE9-dihe-in -125.32, 152.97 APE8-dihe-in -51.44, 112.14 APE8-rot-na 336.6 APE67-dihe-in -70.07, -21.44 -63.76, -36.56 APE12-dist-na 15.2058 APE11-dist-na 10.6866 APE10-dist-na 13.2843 APE9-dist-in 6.9205 None PTR394 PTR394 XRAY 2.55 0.183 0.291 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zyb Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AC1A P06239 231 502 509.0 KZI:514 Type1 Active DFGin 6.4874 14.5417 BLAminus -131.48, -179.03 55.28, 80.68 -95.73, 16.37 295.17, 96.65 -60.65, -33.27 in-in in 8.4917 Saltbr-in 2.8277 HRD-in -98.47, -48.35 73.68, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.9962 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.39, 135.48 APE9-dihe-in -130.85, 154.91 APE8-dihe-in -61.35, 117.59 APE8-rot-na 336.87 APE67-dihe-in -69.89, -26.11 -63.6, -40.28 APE12-dist-na 15.212 APE11-dist-na 10.5248 APE10-dist-na 12.943 APE9-dist-in 6.9436 None PTR394 PTR394 XRAY 1.99 0.161 0.221 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac1 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AC2A P06239 231 502 509.0 KSE:514 Type1 Active DFGin 6.6055 14.5653 BLAminus -135.84, 168.64 64.15, 84.09 -100.36, 19.65 294.74, 98.08 -57.49, -38.24 in-in in 8.6685 Saltbr-in 3.3397 HRD-in -100.58, -48.65 73.34, -4.91 in-in-in SNCiii in-in ActLoopNT-in 2.9031 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 139.12 APE9-dihe-in -135.6, 152.46 APE8-dihe-in -59.2, 122.81 APE8-rot-na 332.56 APE67-dihe-in -68.23, -28.88 -61.81, -41.57 APE12-dist-na 15.2632 APE11-dist-na 10.5795 APE10-dist-na 13.0208 APE9-dist-in 6.8692 None PTR394 PTR394 XRAY 2.1 0.164 0.225 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac2 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AC3A P06239 231 502 509.0 KSH:511 Type1 Active DFGin 6.4587 14.6307 BLAminus -147.21, 174.45 54.99, 89.06 -104.08, 27.27 302.45, 83.28 -58.22, -33.73 in-in in 8.5524 Saltbr-in 2.7449 HRD-in -111.81, -47.37 77.05, -14.83 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.99, 144.35 APE9-dihe-in -134.94, 154.73 APE8-dihe-in -49.27, 117.05 APE8-rot-na 333.21 APE67-dihe-in -65.53, -31.62 -66.91, -37.94 APE12-dist-na 15.2721 APE11-dist-na 10.707 APE10-dist-na 13.3294 APE9-dist-in 6.9376 None PTR394 PTR394 XRAY 2.55 0.209 0.274 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac3 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AC4A P06239 231 502 509.0 KZL:513 Type1 Active DFGin 6.5609 14.9641 BLAminus -134.05, 169.16 63.4, 83.38 -101.46, 27.47 299.41, 85.84 -61.03, -40.36 in-in in 8.6233 Saltbr-in 2.849 HRD-in -99.06, -47.22 74.57, -0.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.44, 142.47 APE9-dihe-in -122.94, 163.65 APE8-dihe-in -61.25, 115.38 APE8-rot-na 337.67 APE67-dihe-in -59.59, -35.92 -64.0, -44.24 APE12-dist-na 15.1738 APE11-dist-na 10.3539 APE10-dist-na 13.4191 APE9-dist-in 7.0638 None PTR394 PTR394 XRAY 2.7 0.211 0.283 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac4 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AC5A P06239 231 502 509.0 KZM:513 Type1 Active DFGin 6.352 13.8552 BLAminus -139.87, -178.59 59.74, 72.52 -92.79, 17.42 308.98, 89.37 -47.63, -35.76 in-in in 8.4029 Saltbr-in 3.207 HRD-in -107.79, -48.48 77.33, -8.64 in-in-in SNCiii in-in ActLoopNT-in 3.1306 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.67, 143.58 APE9-dihe-in -137.14, 147.29 APE8-dihe-in -52.03, 120.11 APE8-rot-na 337.78 APE67-dihe-in -80.56, -23.87 -69.56, -26.75 APE12-dist-na 15.3675 APE11-dist-na 10.6806 APE10-dist-na 12.8971 APE9-dist-in 6.8392 None PTR394 PTR394 XRAY 2.5 0.171 0.268 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ac5 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3ACJA P06239 231 502 509.0 KSS:513 Type1 Active DFGin 6.4972 14.5524 BLAminus -135.95, -178.35 54.49, 81.98 -96.02, 16.9 296.03, 99.25 -59.02, -33.73 in-in in 8.4812 Saltbr-in 2.7335 HRD-in -98.9, -46.49 67.28, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.9428 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.6, 139.05 APE9-dihe-in -134.1, 152.03 APE8-dihe-in -62.65, 126.38 APE8-rot-na 332.51 APE67-dihe-in -67.23, -30.82 -66.13, -39.51 APE12-dist-na 15.3445 APE11-dist-na 10.6097 APE10-dist-na 12.9594 APE9-dist-in 6.8294 None PTR394 PTR394 XRAY 2.2 0.175 0.247 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3acj Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3ACKA P06239 231 502 509.0 KSR:1 Type1 Active DFGin 6.486 14.5539 BLAminus -138.87, 177.35 61.26, 86.12 -103.64, 22.65 299.89, 92.45 -53.76, -45.12 in-in in 8.4365 Saltbr-in 2.7831 HRD-in -99.63, -48.79 75.26, -11.15 in-in-in SNCiii in-in ActLoopNT-in 2.9293 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.48, 136.12 APE9-dihe-in -129.13, 153.79 APE8-dihe-in -53.72, 121.31 APE8-rot-na 336.74 APE67-dihe-in -73.11, -30.35 -74.46, -30.93 APE12-dist-na 15.2411 APE11-dist-na 10.5753 APE10-dist-na 13.1606 APE9-dist-in 6.9279 None PTR394 PTR394 XRAY 2.6 0.18 0.265 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ack Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AD4A P06239 231 502 509.0 KBM:1 Type1 Active DFGin 6.6698 14.7383 BLAminus -138.55, 178.42 55.95, 86.04 -102.66, 22.41 294.12, 99.27 -58.94, -39.61 in-in in 8.418 Saltbr-in 3.1333 HRD-in -98.32, -50.74 80.19, -7.43 in-in-in SNCiii in-in ActLoopNT-in 3.0071 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.34, 135.07 APE9-dihe-in -130.61, 154.41 APE8-dihe-in -64.7, 113.98 APE8-rot-na 336.56 APE67-dihe-in -73.67, -29.83 -58.57, -33.85 APE12-dist-na 15.3949 APE11-dist-na 10.5945 APE10-dist-na 13.2177 APE9-dist-in 6.9036 None PTR394 PTR394 XRAY 2.2 0.177 0.256 A 285.0 272.0 0 29 29 0 [[245, 496]] 1.0 3ad4 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AD5A P06239 230 502 509.0 5PB:1 Type1 Active DFGin 6.53 14.65 BLAminus -133.26, 179.48 56.65, 87.47 -103.27, 22.64 294.72, 94.2 -60.3, -39.81 in-in in 8.6599 Saltbr-in 2.6752 HRD-in -100.6, -52.09 78.06, -7.01 in-in-in SNCiii in-in ActLoopNT-in 2.8767 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.99, 138.23 APE9-dihe-in -134.82, 155.62 APE8-dihe-in -60.84, 123.2 APE8-rot-na 336.01 APE67-dihe-in -67.8, -24.85 -60.78, -43.22 APE12-dist-na 15.3948 APE11-dist-na 10.7224 APE10-dist-na 13.0487 APE9-dist-in 6.8034 None PTR394 PTR394 XRAY 2.0 0.161 0.218 A 285.0 273.0 0 29 29 0 [[245, 496]] 1.0 3ad5 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AD6A P06239 230 502 509.0 KSC:513 Type1 Active DFGin 6.6063 14.6171 BLAminus -137.3, 174.91 63.11, 87.06 -102.53, 22.84 293.54, 102.07 -62.24, -35.85 in-in in 8.5974 Saltbr-in 2.9461 HRD-in -96.19, -55.02 79.01, -5.26 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.04, 143.95 APE9-dihe-in -136.21, 160.1 APE8-dihe-in -66.15, 124.74 APE8-rot-na 332.64 APE67-dihe-in -70.22, -24.36 -63.01, -43.59 APE12-dist-na 15.0858 APE11-dist-na 10.6055 APE10-dist-na 13.282 APE9-dist-in 6.9252 None PTR394 PTR394 XRAY 2.15 0.192 0.27 A 285.0 273.0 0 29 29 0 [[245, 496]] 1.0 3ad6 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3KXZA P06239 238 501 509.0 925:1 Type1 Active DFGin 6.2682 13.7963 BLAminus -141.81, -179.26 62.44, 72.38 -97.35, 29.16 312.06, 86.33 -58.6, -39.88 in-in in 8.2727 Saltbr-in 3.384 HRD-in -90.63, -51.83 75.7, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.7679 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.23, 135.78 APE9-dihe-in -129.65, 157.14 APE8-dihe-in -59.67, 101.6 APE8-rot-na 19.72 APE67-dihe-in -66.72, -21.47 -50.87, -46.22 APE12-dist-na 14.4422 APE11-dist-na 9.8007 APE10-dist-na 12.4931 APE9-dist-in 6.6817 None PTR394 PTR394 XRAY 2.37 0.195 0.261 A 287.0 264.0 0 29 29 0 [[245, 496]] 1.0 3kxz Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.4653 14.1815 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.4176 Saltbr-in 2.8434 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.9762 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.2937 APE10-dist-na 12.9671 APE9-dist-in 6.9506 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpd Homo sapiens TYR_LCK_HUMAN TYR 3.6e-93 317.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3BYMA P06239 230 501 509.0 AM0:1 Type1.5_Back Active DFGin 6.5992 14.335 BLAminus -129.71, -173.8 43.96, 88.25 -99.71, 20.36 296.76, 99.13 -53.01, -42.28 in-in in 8.6491 Saltbr-in 2.6173 HRD-in -95.94, -50.0 73.2, -8.73 in-in-in SNCiii in-in ActLoopNT-in 2.9487 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.01, 147.55 APE9-dihe-in -139.76, 155.99 APE8-dihe-in -53.78, 113.22 APE8-rot-na 329.24 APE67-dihe-in -65.1, -24.46 -57.96, -45.81 APE12-dist-na 14.721 APE11-dist-na 10.0295 APE10-dist-na 12.8419 APE9-dist-in 6.9447 None PTR394 PTR394 XRAY 2.0 0.226 0.274 A 272.0 272.0 0 29 29 0 [[245, 496]] 1.0 3bym Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.3 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3KMMA P06239 231 501 509.0 LHL:1 Type1.5_Back Active DFGin 6.8628 14.8299 BLAminus -127.6, -179.98 60.86, 89.79 -112.67, 27.22 299.87, 93.25 -61.87, -31.32 in-in in 8.6985 Saltbr-in 3.0559 HRD-in -91.14, -53.45 82.64, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.8642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.65, 152.15 APE9-dihe-in -136.18, 157.7 APE8-dihe-in -58.05, 115.06 APE8-rot-na 339.75 APE67-dihe-in -80.51, -24.68 -64.53, -28.52 APE12-dist-na 14.1508 APE11-dist-na 9.7097 APE10-dist-na 12.3903 APE9-dist-in 6.6287 Y505F PTR394 PTR394 XRAY 2.8 0.167 0.223 A 288.0 271.0 0 29 29 0 [[245, 496]] 1.0 3kmm Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3AC8A P06239 231 501 509.0 KSK:1 Type1 Inactive DFGin 6.1602 14.2955 BLAminus -149.31, -179.38 58.87, 71.98 -93.0, 13.95 295.99, 89.12 -55.97, -30.75 in-out in 7.6137 Saltbr-out 4.721 HRD-in -95.71, -45.58 76.13, -14.85 out-in-in SNCoii in-in ActLoopNT-in 3.1553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.54, 135.63 APE9-dihe-in -130.81, 156.67 APE8-dihe-in -56.6, 115.07 APE8-rot-na 334.98 APE67-dihe-in -68.56, -21.46 -66.79, -40.68 APE12-dist-na 15.4712 APE11-dist-na 10.7439 APE10-dist-na 13.1651 APE9-dist-in 6.8929 None PTR394 PTR394 XRAY 2.3 0.229 0.318 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 3ac8 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3B2WA P06239 238 500 509.0 9NH:601 Type1 Inactive DFGin 8.1642 16.9346 BLBminus -130.29, 174.3 30.22, 87.79 -64.26, 150.62 282.55, 10.68 -81.48, 131.12 in-in in 8.328 Saltbr-in 2.7673 HRD-in -83.28, -59.73 86.44, -15.17 in-out-out SNCioo out-out ActLoopNT-out 10.5165 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.56, -173.59 APE9-dihe-in -132.73, 178.81 APE8-dihe-in -73.78, 81.88 APE8-rot-na 335.17 APE67-dihe-in -55.0, -12.15 -34.45, -62.51 APE12-dist-na 14.6694 APE11-dist-na 10.0108 APE10-dist-na 12.6603 APE9-dist-in 6.7753 None None None XRAY 2.3 0.23 0.308 A 277.0 261.0 2 29 27 2 [[245, 496]] 1.0 3b2w Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3MPMA P06239 238 498 509.0 5LK:1 Type1 Inactive DFGin 4.0001 14.5184 BLBplus -117.53, 162.1 59.07, 39.27 -86.64, 152.74 45.5, 92.82 74.34, 9.15 in-in in 7.9413 Saltbr-in 3.2839 HRD-in -88.49, -65.37 87.18, -21.73 in-out-out SNCioo out-out ActLoopNT-out 9.2274 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.26 APE8-dihe-out -60.9, 40.06 APE8-rot-na 23.67 APE67-dihe-in -68.02, -9.13 -55.59, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.884 D364N None None XRAY 1.95 0.172 0.213 A 267.0 257.0 4 29 25 4 [[245, 496]] 1.0 3mpm Homo sapiens TYR_LCK_HUMAN TYR 4.4e-94 320.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 4C3FA P06239 238 498 509.0 7KW:1499 Type1 Inactive DFGin 3.8792 14.4626 BLBplus -108.47, 162.66 60.18, 42.82 -97.37, 146.43 48.08, 83.58 82.78, 5.71 in-in in 8.0144 Saltbr-in 3.073 HRD-in -84.53, -65.16 86.44, -20.06 in-out-out SNCioo out-out ActLoopNT-out 9.1246 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.3 APE8-dihe-in -70.1, 116.34 APE8-rot-na 22.73 APE67-dihe-in -69.5, -8.96 -127.83, -9.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8973 D364N None None XRAY 1.72 0.18 0.22 A 267.0 257.0 4 29 25 4 [[245, 496]] 1.0 4c3f Homo sapiens TYR_LCK_HUMAN TYR 4.4e-94 320.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 6PDJA P06239 225 500 509.0 ODJ:60601 Type1.5_Front Inactive DFGout 11.3506 8.9556 BBAminus -108.06, 146.7 -118.62, 138.04 -125.67, 34.93 300.23, 95.6 96.65, -2.92 out-none out 17.1148 Saltbr-none 999.0 HRD-in -91.73, -46.03 72.74, -1.78 none-in-in SNCnii in-in ActLoopNT-in 2.9016 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.11, 126.2 APE9-dihe-in -121.94, 158.33 APE8-dihe-in -71.45, 105.31 APE8-rot-na 23.06 APE67-dihe-in -61.4, -18.91 -48.25, -48.5 APE12-dist-na 15.0074 APE11-dist-na 10.5909 APE10-dist-na 12.8875 APE9-dist-in 6.8558 None PTR394 PTR394 XRAY 1.81 0.169 0.217 A 288.0 271.0 0 29 29 0 [[245, 496]] 1.0 6pdj Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OG8A P06239 237 499 509.0 1N8:60501 Type2 Inactive DFGout 13.8808 10.9925 BBAminus -146.02, -178.48 -159.06, 109.07 -91.7, -32.13 313.79, 133.51 123.25, 172.44 in-in in 7.5355 Saltbr-in 2.5546 HRD-in -72.68, -47.71 77.3, -17.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 90.85 APE8-rot-na 331.72 APE67-dihe-in -42.21, -25.74 -101.86, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 A 265.0 246.0 17 29 12 17 [[245, 496]] 1.0 2og8 Homo sapiens TYR_LCK_HUMAN TYR 1.1e-94 322.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OG8B P06239 237 499 509.0 1N8:60502 Type2 Inactive DFGout 13.7734 11.422 BBAminus -151.29, 173.3 -150.55, 99.91 -84.69, -22.72 312.06, 114.32 85.84, -73.71 in-in in 7.891 Saltbr-in 2.7303 HRD-in -73.85, -45.85 72.78, -12.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -121.15 APE8-rot-na 325.14 APE67-dihe-in -36.14, -21.79 -90.01, -51.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.247 0.3 B 265.0 247.0 16 29 13 16 [[245, 496]] 1.0 2og8 Homo sapiens TYR_LCK_HUMAN TYR 1.1e-94 322.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3BYSA P06239 230 501 509.0 AM5:1 Type2 Inactive DFGout 13.9888 10.6423 BBAminus -142.64, -177.35 -158.61, 106.94 -89.7, 9.59 310.93, 117.54 52.15, 70.11 in-in in 8.12 Saltbr-in 2.7074 HRD-in -64.24, -46.91 79.98, -22.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.4 APE8-rot-na 312.02 APE67-dihe-out -44.95, -20.15 53.78, -66.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.246 0.284 A 277.0 255.0 17 29 12 17 [[245, 496]] 1.0 3bys Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 3BYUA P06239 231 501 509.0 AM6:1 Type2 Inactive DFGout 14.194 10.6001 BBAminus -142.65, -178.45 -160.75, 101.5 -80.8, 5.51 308.08, 121.67 47.71, 62.39 in-in in 8.1652 Saltbr-in 3.1302 HRD-in -72.18, -47.4 76.26, -12.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioao APEdist_aaai APE10-dihe-none 999.0, 103.64 APE9-dihe-in -86.73, 103.84 APE8-dihe-out -31.76, 27.45 APE8-rot-na 312.67 APE67-dihe-out -39.72, -28.73 61.22, -78.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.3313 APE9-dist-in 6.5914 None None None XRAY 2.3 0.232 0.278 A 277.0 256.0 15 29 14 15 [[245, 496]] 1.0 3byu Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2PL0A P06239 231 498 509.0 STI:200 Type2 Inactive DFGout 13.4391 10.9797 BBAminus -123.86, 162.41 -130.4, 102.99 -85.25, -1.39 299.47, 139.85 60.55, 49.25 in-in in 8.1088 Saltbr-in 2.891 HRD-in -103.3, -55.77 88.99, -24.94 in-out-in SNCioi out-in ActLoopNT-out 14.6912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.65, 127.24 APE9-dihe-in -162.32, 149.69 APE8-dihe-in -67.62, 110.43 APE8-rot-na 341.58 APE67-dihe-in -77.58, -4.79 -53.82, -46.7 APE12-dist-na 16.3279 APE11-dist-na 13.4942 APE10-dist-na 8.8097 APE9-dist-in 5.8879 None None None XRAY 2.8 0.215 0.261 A 289.0 268.0 0 29 29 0 [[245, 496]] 1.0 2pl0 Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OFVA P06239 232 498 509.0 242:60503 Type2 Inactive DFGout 14.7252 10.522 None -150.8, 177.89 -156.14, 104.83 -146.7, 29.24 58.19, 94.86 -70.67, -18.76 in-in in 8.1017 Saltbr-in 2.8157 HRD-in -63.81, -56.73 81.39, -17.57 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -66.38, -9.13 999.0, 161.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 A 277.0 243.0 24 29 12 17 [[245, 496]] 1.0 2ofv Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
LCK LCK_HUMAN 2OFVB P06239 232 498 509.0 242:60503 Type2 Inactive DFGout 14.6309 10.6606 None -147.07, -175.72 -160.36, 105.8 -148.26, 28.72 55.51, 100.37 -69.36, -20.81 in-in in 7.9375 Saltbr-in 2.7974 HRD-in -66.99, -53.14 73.02, -17.06 in-out-none SNCion out-none ActLoopNT-out 11.8667 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.76 APE8-rot-na 999.0 APE67-dihe-in -65.32, -16.12 -30.26, -66.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.274 0.301 B 277.0 243.0 24 29 18 11 [[245, 496]] 1.0 2ofv Homo sapiens TYR_LCK_HUMAN TYR 1.3e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name