TYR_FGFR2 (Fibroblast growth factor receptor 2)

Total number of chains: 99
Active chains: 5
Uniprot: FGFR2_HUMAN
Kinase Domain Residues: 481 - 759
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 88 88.9% AF-P21802-K1A
DFGin BLAplus 7 7.1% 8W2XA
DFGin None 3 3.0% 8STGB
DFGin BLBminus 1 1.0% 6V6QC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
2PVFA 467 765 821.0 ACP:60300 ATPlike Active DFGin 6.048 13.821 BLAminus -138.88, -175.17 54.67, 80.46 -90.11, 24.33 291.08, 76.38 -54.38, -36.38 in-in in 7.913 Saltbr-in 2.769 HRD-in -85.37, -48.4 70.03, 0.26 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.94, 115.27 APE9-dihe-in -125.87, 160.91 APE8-dihe-in -74.41, 68.1 APE8-rot-na 35.92 APE67-dihe-in -70.82, -9.54 -47.44, -41.99 APE12-dist-na 15.14 APE11-dist-na 11.649 APE10-dist-na 11.604 APE9-dist-in 7.168 C491A PTR586,PTR656,PTR657 PTR586,PTR656,PTR657 XRAY 1.8 0.251 0.265 A 334 288 11 0 0 0 [[481, 759]] 1.0 2pvf TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
3CLYA 468 772 821.0 ACP:61803 ATPlike Active DFGin 6.229 14.183 BLAminus -138.78, -172.76 51.4, 79.79 -91.29, 32.46 290.47, 75.81 -61.86, -29.26 in-in in 7.661 Saltbr-in 2.621 HRD-in -89.86, -45.92 68.93, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.79, 139.96 APE9-dihe-in -131.36, 152.18 APE8-dihe-in -76.17, 66.16 APE8-rot-na 37.1 APE67-dihe-in -66.78, -6.73 -47.95, -40.48 APE12-dist-na 13.253 APE11-dist-na 10.402 APE10-dist-na 11.097 APE9-dist-in 6.913 C491A PTR656,PTR657 PTR656,PTR657 XRAY 2.0 0.216 0.247 A 334 291 14 0 0 0 [[481, 759]] 1.0 3cly TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5EG3A 466 774 821.0 ACP:60801 ATPlike Active DFGin 6.034 13.825 BLAminus -138.71, -166.61 47.53, 87.44 -100.17, 28.73 285.85, 82.29 -77.8, -14.99 in-in in 8.045 Saltbr-in 2.941 HRD-in -83.82, -45.21 62.18, 9.75 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.56, 121.06 APE9-dihe-in -128.9, 119.34 APE8-dihe-in -79.6, 67.11 APE8-rot-na 30.51 APE67-dihe-in -77.81, 0.08 -48.0, -39.27 APE12-dist-na 13.558 APE11-dist-na 10.078 APE10-dist-na 8.259 APE9-dist-in 7.021 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E PTR769 PTR769 XRAY 2.606 0.191 0.237 A 334 302 7 0 0 0 [[481, 759]] 1.0 5eg3 TYR_FGFR2_HUMAN TYR 2.3e-101 344.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
AF-P21802-K1A 473 767 821.0 No_ligand No_ligand Active DFGin 6.601 13.828 BLAminus -133.68, -169.57 52.57, 69.39 -87.88, 10.6 290.58, 96.54 -58.9, -30.33 in-in in 7.455 Saltbr-in 2.604 HRD-in -70.96, -43.8 66.39, -18.89 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.66, 121.21 APE9-dihe-in -133.82, 152.44 APE8-dihe-in -79.15, 83.67 APE8-rot-na 36.61 APE67-dihe-in -67.33, -12.18 -47.11, -39.95 APE12-dist-na 14.429 APE11-dist-na 9.835 APE10-dist-na 10.022 APE9-dist-in 6.266 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[481, 759]] 1.0 AF-P21802-K1 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
AF-P21802-K3A 473 767 821.0 No_ligand No_ligand Active DFGin 6.209 13.501 BLAminus -141.01, -176.93 60.04, 66.75 -80.69, 12.07 290.46, 96.57 -59.23, -29.09 in-in in 7.925 Saltbr-in 2.657 HRD-in -80.72, -44.06 61.54, -5.0 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.89, 136.41 APE9-dihe-in -134.04, 129.71 APE8-dihe-in -82.57, 64.16 APE8-rot-na 35.64 APE67-dihe-in -69.31, -10.22 -46.98, -44.55 APE12-dist-na 13.459 APE11-dist-na 9.774 APE10-dist-na 8.159 APE9-dist-in 6.654 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[481, 759]] 1.0 AF-P21802-K3 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PWLA 467 764 821.0 ACP:300 ATPlike Inactive DFGin 6.451 14.178 BLAminus -131.61, -167.38 56.51, 73.64 -92.98, 26.06 293.6, 74.93 -63.45, -20.7 in-in in 7.586 Saltbr-in 2.856 HRD-in -77.4, -49.09 71.28, -7.85 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.03, 20.75 APE9-dihe-in -94.74, 135.38 APE8-dihe-in -58.69, 123.68 APE8-rot-na 326.81 APE67-dihe-in -69.99, -5.92 -52.74, -45.54 APE12-dist-na 10.002 APE11-dist-na 10.678 APE10-dist-na 7.432 APE9-dist-in 4.749 C491A,N549H None None XRAY 2.4 0.21 0.238 A 324 284 14 0 0 0 [[481, 759]] 1.0 2pwl TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PWLB 468 765 821.0 ACP:300 ATPlike Inactive DFGin 6.439 14.28 BLAminus -131.94, -168.62 54.17, 75.02 -93.02, 25.01 292.99, 76.23 -61.28, -25.59 in-in in 7.692 Saltbr-in 3.07 HRD-in -69.87, -47.96 69.48, -8.93 in-in-out SNCiio in-out ActLoopNT-in 2.916 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.23, 16.85 APE9-dihe-in -95.43, 136.0 APE8-dihe-in -55.13, 121.27 APE8-rot-na 324.13 APE67-dihe-in -66.61, -7.86 -55.94, -44.16 APE12-dist-na 10.089 APE11-dist-na 10.854 APE10-dist-na 7.485 APE9-dist-in 4.912 C491A,N549H None None XRAY 2.4 0.21 0.238 B 324 286 12 0 0 0 [[481, 759]] 1.0 2pwl TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UGLA 468 764 821.0 ANP:802 ATPlike Inactive DFGin 6.732 14.464 BLAminus -137.83, -175.53 60.75, 66.42 -85.03, 17.04 287.79, 92.86 -66.15, -23.38 in-in in 7.669 Saltbr-in 2.761 HRD-in -76.2, -48.26 75.23, -6.81 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.99, 26.82 APE9-dihe-in -107.7, 135.68 APE8-dihe-in -52.5, 118.32 APE8-rot-na 330.79 APE67-dihe-in -70.92, -8.04 -59.23, -38.34 APE12-dist-na 14.887 APE11-dist-na 10.816 APE10-dist-na 7.642 APE9-dist-in 5.103 D650V None None XRAY 1.861 0.221 0.258 A 324 285 12 0 0 0 [[481, 759]] 1.0 5ugl TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UGLB 467 764 821.0 ANP:802 ATPlike Inactive DFGin 6.738 14.48 BLAminus -137.57, -172.18 55.78, 69.64 -87.75, 15.81 286.63, 92.96 -64.54, -22.36 in-in in 7.653 Saltbr-in 2.718 HRD-in -74.83, -48.38 75.49, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.07, 25.73 APE9-dihe-in -107.84, 135.51 APE8-dihe-in -51.06, 118.2 APE8-rot-na 329.13 APE67-dihe-in -71.28, -8.69 -57.7, -39.45 APE12-dist-na 999.0 APE11-dist-na 10.831 APE10-dist-na 7.669 APE9-dist-in 5.084 D650V None None XRAY 1.861 0.221 0.258 B 324 271 27 0 0 11 [[481, 759]] 1.0 5ugl TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J96B 462 766 821.0 ACP:803 ATPlike Inactive DFGin 6.422 14.069 BLAminus -135.07, -171.17 49.96, 77.75 -93.13, 20.28 283.65, 85.2 -66.67, -18.8 in-out in 7.205 Saltbr-out 3.691 HRD-in -86.85, -47.88 76.0, -13.66 out-in-out SNCoio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 28.85 APE9-dihe-in -99.38, 128.67 APE8-dihe-in -54.56, 125.51 APE8-rot-na 329.88 APE67-dihe-in -70.35, -5.29 -58.48, -39.96 APE12-dist-na 14.724 APE11-dist-na 10.154 APE10-dist-na 7.507 APE9-dist-in 4.93 C491A,K659M None None XRAY 2.297 0.178 0.219 B 324 305 0 0 0 0 [[481, 759]] 1.0 4j96 TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J98B 461 764 821.0 ACP:804 ATPlike Inactive DFGin 6.55 14.042 BLAminus -130.09, -172.54 52.51, 78.98 -94.32, 21.96 285.07, 86.18 -63.61, -22.45 in-in in 7.113 Saltbr-in 3.017 HRD-in -86.21, -48.16 74.7, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.22, 26.63 APE9-dihe-in -99.48, 124.84 APE8-dihe-in -50.97, 125.51 APE8-rot-na 328.99 APE67-dihe-in -68.16, -7.57 -60.28, -41.11 APE12-dist-na 15.096 APE11-dist-na 10.418 APE10-dist-na 7.58 APE9-dist-in 4.827 C491A,K659Q None None XRAY 2.307 0.19 0.234 B 324 304 0 0 0 0 [[481, 759]] 1.0 4j98 TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J99A 466 764 821.0 ACP:802 ATPlike Inactive DFGin 6.715 14.14 BLAminus -130.96, -174.69 58.83, 77.45 -92.73, 19.29 291.78, 87.39 -60.03, -34.11 in-in in 7.61 Saltbr-in 2.845 HRD-in -78.19, -48.52 73.01, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.36, 29.03 APE9-dihe-in -109.75, 138.54 APE8-dihe-in -57.3, 116.33 APE8-rot-na 330.48 APE67-dihe-in -70.7, -10.42 -57.47, -40.52 APE12-dist-na 15.04 APE11-dist-na 11.232 APE10-dist-na 7.972 APE9-dist-in 5.13 C491A,K659T None None XRAY 1.847 0.206 0.24 A 324 280 19 0 0 4 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J99B 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.666 14.188 BLAminus -133.21, -176.0 58.56, 76.97 -94.04, 15.78 292.83, 99.53 -58.91, -32.83 in-in in 7.584 Saltbr-in 2.616 HRD-in -76.65, -48.86 73.31, -6.92 in-in-out SNCiio in-out ActLoopNT-in 2.9 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.89, 30.62 APE9-dihe-in -108.84, 137.25 APE8-dihe-in -57.12, 118.19 APE8-rot-na 330.19 APE67-dihe-in -70.1, -10.12 -57.01, -39.76 APE12-dist-na 14.148 APE11-dist-na 11.074 APE10-dist-na 8.007 APE9-dist-in 5.18 C491A,K659T None None XRAY 1.847 0.206 0.24 B 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J99C 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.835 14.168 BLAminus -131.87, -175.54 59.17, 75.71 -91.42, 19.92 291.67, 85.71 -59.92, -32.59 in-in in 7.628 Saltbr-in 2.913 HRD-in -76.88, -47.72 74.23, -7.36 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.66, 30.6 APE9-dihe-in -110.19, 138.06 APE8-dihe-in -55.44, 118.46 APE8-rot-na 330.51 APE67-dihe-in -70.73, -10.29 -57.12, -38.65 APE12-dist-na 14.121 APE11-dist-na 10.954 APE10-dist-na 8.05 APE9-dist-in 5.362 C491A,K659T None None XRAY 1.847 0.206 0.24 C 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J99D 465 764 821.0 ACP:802 ATPlike Inactive DFGin 6.593 14.159 BLAminus -133.66, -174.57 58.72, 78.56 -92.61, 20.44 290.96, 82.99 -59.4, -33.38 in-in in 7.631 Saltbr-in 2.639 HRD-in -78.38, -50.11 73.68, -6.22 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.76, 31.03 APE9-dihe-in -108.34, 137.61 APE8-dihe-in -55.35, 118.06 APE8-rot-na 330.85 APE67-dihe-in -71.9, -11.56 -55.67, -38.95 APE12-dist-na 999.0 APE11-dist-na 11.135 APE10-dist-na 7.859 APE9-dist-in 4.992 C491A,K659T None None XRAY 1.847 0.206 0.24 D 324 281 19 0 0 3 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PVYA 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.75 14.274 BLAminus -142.14, -176.01 63.9, 72.69 -96.2, 30.01 293.76, 86.07 -65.9, -30.73 in-in in 7.547 Saltbr-in 2.852 HRD-in -84.99, -48.7 74.29, -16.98 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.15, 32.71 APE9-dihe-in -103.67, 126.67 APE8-dihe-in -51.63, 122.63 APE8-rot-na 323.69 APE67-dihe-in -64.04, -12.74 -56.98, -40.88 APE12-dist-na 14.814 APE11-dist-na 10.095 APE10-dist-na 7.537 APE9-dist-in 4.955 C491A,K659N None None XRAY 2.2 0.236 0.276 A 324 288 10 0 0 0 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PVYB 462 764 821.0 ACP:8002 ATPlike Inactive DFGin 6.635 14.065 BLAminus -144.27, -177.95 57.14, 77.78 -93.97, 24.89 293.34, 84.21 -55.49, -34.1 in-in in 7.316 Saltbr-in 2.847 HRD-in -81.21, -48.71 71.97, -12.52 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.68, 30.22 APE9-dihe-in -107.46, 135.49 APE8-dihe-in -57.98, 120.91 APE8-rot-na 329.38 APE67-dihe-in -64.69, -5.42 -51.47, -46.8 APE12-dist-na 999.0 APE11-dist-na 10.694 APE10-dist-na 7.435 APE9-dist-in 5.066 C491A,K659N None None XRAY 2.2 0.236 0.276 B 324 286 17 0 0 6 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PVYC 462 764 821.0 ACP:802 ATPlike Inactive DFGin 6.693 14.018 BLAminus -131.41, -174.32 49.42, 82.58 -94.81, 27.78 293.52, 79.4 -60.72, -24.91 in-in in 7.229 Saltbr-in 3.577 HRD-in -81.5, -47.6 72.07, -14.53 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.89, 24.55 APE9-dihe-in -101.87, 134.03 APE8-dihe-in -55.3, 120.87 APE8-rot-na 330.19 APE67-dihe-in -64.04, -6.89 -51.83, -46.76 APE12-dist-na 14.316 APE11-dist-na 10.323 APE10-dist-na 7.438 APE9-dist-in 5.069 C491A,K659N None None XRAY 2.2 0.236 0.276 C 324 285 18 0 0 5 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PVYD 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.944 14.261 BLAminus -139.76, -174.3 61.15, 74.17 -97.41, 31.68 293.81, 79.18 -66.75, -30.92 in-in in 7.298 Saltbr-in 3.036 HRD-in -85.65, -49.02 75.46, -18.01 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.37, 33.11 APE9-dihe-in -102.8, 126.29 APE8-dihe-in -51.84, 123.89 APE8-rot-na 324.49 APE67-dihe-in -63.66, -13.12 -61.69, -37.66 APE12-dist-na 14.828 APE11-dist-na 10.092 APE10-dist-na 7.57 APE9-dist-in 4.968 C491A,K659N None None XRAY 2.2 0.236 0.276 D 324 283 15 0 0 0 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J95A 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.691 14.058 BLAminus -131.56, -174.19 63.25, 76.63 -98.25, 22.24 292.31, 85.68 -64.6, -23.3 in-in in 7.752 Saltbr-in 2.811 HRD-in -79.93, -52.54 74.87, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.79, 21.67 APE9-dihe-in -99.53, 131.21 APE8-dihe-in -54.93, 120.24 APE8-rot-na 331.68 APE67-dihe-in -73.86, -8.05 -61.39, -39.09 APE12-dist-na 14.773 APE11-dist-na 10.953 APE10-dist-na 7.48 APE9-dist-in 4.867 C491A,K659N None None XRAY 2.377 0.214 0.255 A 324 279 19 0 0 4 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J95B 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.677 14.378 BLAminus -131.79, -176.38 62.78, 77.42 -96.59, 21.6 290.19, 86.46 -65.99, -23.31 in-in in 7.797 Saltbr-in 2.903 HRD-in -80.06, -52.15 74.05, -5.91 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.95, 20.73 APE9-dihe-in -101.19, 131.88 APE8-dihe-in -53.9, 121.25 APE8-rot-na 331.03 APE67-dihe-in -73.96, -6.54 -59.67, -39.95 APE12-dist-na 14.977 APE11-dist-na 11.021 APE10-dist-na 7.709 APE9-dist-in 4.856 C491A,K659N None None XRAY 2.377 0.214 0.255 B 324 282 15 0 0 0 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J95C 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.762 14.317 BLAminus -132.19, -176.54 63.57, 76.14 -98.34, 23.39 290.03, 85.39 -65.87, -22.89 in-in in 7.736 Saltbr-in 2.825 HRD-in -79.64, -52.73 75.27, -7.0 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.5, 23.85 APE9-dihe-in -97.28, 128.27 APE8-dihe-in -54.92, 121.79 APE8-rot-na 330.61 APE67-dihe-in -73.19, -7.42 -60.17, -39.19 APE12-dist-na 14.732 APE11-dist-na 10.365 APE10-dist-na 7.413 APE9-dist-in 4.906 C491A,K659N None None XRAY 2.377 0.214 0.255 C 324 281 16 0 0 0 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J95D 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.601 14.074 BLAminus -131.84, -175.28 62.91, 77.06 -96.79, 22.82 289.52, 85.1 -64.56, -22.95 in-in in 7.641 Saltbr-in 2.747 HRD-in -80.37, -53.3 74.73, -6.2 in-in-out SNCiio in-out ActLoopNT-in 3.033 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.03, 23.13 APE9-dihe-in -98.93, 130.46 APE8-dihe-in -52.66, 122.62 APE8-rot-na 330.72 APE67-dihe-in -75.07, -8.74 -59.5, -40.3 APE12-dist-na 999.0 APE11-dist-na 10.804 APE10-dist-na 7.616 APE9-dist-in 4.803 C491A,K659N None None XRAY 2.377 0.214 0.255 D 324 271 27 0 0 11 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PZ5A 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.27 14.129 BLAminus -134.55, -165.25 46.14, 76.71 -87.82, 24.61 288.3, 73.06 -57.77, -17.99 in-in in 7.376 Saltbr-in 2.72 HRD-in -71.49, -53.18 74.61, -7.33 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.92, 23.05 APE9-dihe-in -100.29, 130.1 APE8-dihe-in -50.24, 116.35 APE8-rot-na 324.43 APE67-dihe-in -70.43, -5.4 -48.06, -44.87 APE12-dist-na 10.162 APE11-dist-na 10.892 APE10-dist-na 7.555 APE9-dist-in 4.83 C491A,N549T None None XRAY 2.4 0.214 0.254 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PZ5B 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.42 14.223 BLAminus -139.02, -170.4 49.42, 74.35 -88.07, 29.83 289.06, 77.09 -65.84, -12.67 in-in in 7.304 Saltbr-in 2.773 HRD-in -68.79, -48.45 71.17, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.66, 23.86 APE9-dihe-in -102.44, 130.7 APE8-dihe-in -54.21, 119.21 APE8-rot-na 323.97 APE67-dihe-in -67.2, -7.87 -53.61, -43.12 APE12-dist-na 10.046 APE11-dist-na 10.812 APE10-dist-na 7.393 APE9-dist-in 4.981 C491A,N549T None None XRAY 2.4 0.214 0.254 B 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J97A 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.55 14.123 BLAminus -139.14, -173.61 59.78, 71.54 -95.85, 23.3 290.64, 88.77 -67.56, -16.73 in-in in 7.316 Saltbr-in 3.004 HRD-in -83.97, -47.07 72.51, -7.44 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.39, 21.13 APE9-dihe-in -97.79, 130.15 APE8-dihe-in -58.11, 126.83 APE8-rot-na 332.95 APE67-dihe-in -66.85, -7.34 -61.56, -42.87 APE12-dist-na 15.336 APE11-dist-na 10.692 APE10-dist-na 7.744 APE9-dist-in 4.882 C491A,K659E None None XRAY 2.548 0.202 0.257 A 324 282 15 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J97B 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.619 14.161 BLAminus -137.2, -170.97 56.98, 77.11 -102.2, 28.96 291.71, 89.32 -70.08, -17.2 in-in in 7.432 Saltbr-in 2.683 HRD-in -92.02, -43.47 71.93, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.22, 28.28 APE9-dihe-in -102.89, 130.04 APE8-dihe-in -52.94, 125.61 APE8-rot-na 331.88 APE67-dihe-in -68.38, -8.99 -59.09, -43.64 APE12-dist-na 15.333 APE11-dist-na 10.637 APE10-dist-na 7.778 APE9-dist-in 4.888 C491A,K659E None None XRAY 2.548 0.202 0.257 B 324 283 14 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J97C 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.645 13.946 BLAminus -135.48, -176.12 59.98, 78.76 -103.0, 29.61 294.18, 85.28 -73.23, -9.75 in-in in 7.37 Saltbr-in 2.772 HRD-in -84.13, -44.14 69.93, -6.04 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 19.13 APE9-dihe-in -91.95, 123.86 APE8-dihe-in -53.96, 120.55 APE8-rot-na 330.23 APE67-dihe-in -67.12, -15.11 -56.46, -44.57 APE12-dist-na 15.284 APE11-dist-na 10.828 APE10-dist-na 7.639 APE9-dist-in 4.85 C491A,K659E None None XRAY 2.548 0.202 0.257 C 324 283 15 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J97D 466 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6 13.952 BLAminus -140.55, -174.15 59.58, 71.6 -94.76, 28.97 293.72, 82.5 -71.76, -12.96 in-in in 7.326 Saltbr-in 3.288 HRD-in -86.64, -45.82 71.0, -4.65 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.43, 15.17 APE9-dihe-in -92.91, 126.7 APE8-dihe-in -55.77, 123.75 APE8-rot-na 332.18 APE67-dihe-in -67.8, -5.5 -58.98, -44.55 APE12-dist-na 15.175 APE11-dist-na 10.81 APE10-dist-na 7.653 APE9-dist-in 4.774 C491A,K659E None None XRAY 2.548 0.202 0.257 D 324 285 14 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PZPA 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.348 14.188 BLAminus -137.17, -165.33 46.36, 75.76 -87.8, 26.94 288.76, 75.56 -66.87, -3.87 in-in in 7.412 Saltbr-in 2.646 HRD-in -73.32, -51.09 75.46, -8.12 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.47, 19.17 APE9-dihe-in -100.03, 131.76 APE8-dihe-in -52.44, 119.43 APE8-rot-na 323.26 APE67-dihe-in -75.98, -2.12 -50.98, -36.8 APE12-dist-na 10.034 APE11-dist-na 10.845 APE10-dist-na 7.456 APE9-dist-in 4.835 C491A,K526E None None XRAY 2.4 0.214 0.251 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pzp TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PZPB 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.413 14.352 BLAminus -140.32, -168.12 49.24, 73.06 -87.89, 30.48 288.51, 77.76 -65.07, -14.98 in-in in 7.479 Saltbr-in 2.588 HRD-in -76.07, -43.76 66.74, -12.17 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.0, 26.29 APE9-dihe-in -103.21, 127.34 APE8-dihe-in -50.89, 117.65 APE8-rot-na 324.07 APE67-dihe-in -70.61, -2.41 -52.07, -42.82 APE12-dist-na 10.141 APE11-dist-na 10.802 APE10-dist-na 7.451 APE9-dist-in 4.964 C491A,K526E None None XRAY 2.4 0.214 0.251 B 324 282 17 0 0 0 [[481, 759]] 1.0 2pzp TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PZRA 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.528 14.087 BLAminus -124.48, -173.68 60.99, 80.27 -100.69, 20.88 290.45, 81.11 -57.12, -25.75 in-in in 7.418 Saltbr-in 2.648 HRD-in -69.22, -43.88 65.36, -10.35 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.95, 17.65 APE9-dihe-in -96.03, 130.55 APE8-dihe-in -55.73, 111.71 APE8-rot-na 326.73 APE67-dihe-in -57.11, -22.38 -39.78, -52.21 APE12-dist-na 9.973 APE11-dist-na 10.692 APE10-dist-na 7.386 APE9-dist-in 4.734 C491A,K641R None None XRAY 3.0 0.201 0.268 A 324 280 18 0 0 0 [[481, 759]] 1.0 2pzr TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PZRB 467 766 821.0 ACP:803 ATPlike Inactive DFGin 6.446 14.135 BLAminus -124.12, -169.42 57.57, 72.92 -93.39, 13.68 295.44, 82.57 -53.73, -21.74 in-in in 7.634 Saltbr-in 2.706 HRD-in -69.55, -51.19 76.09, -22.69 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.28, 13.02 APE9-dihe-in -94.85, 132.36 APE8-dihe-in -55.27, 118.14 APE8-rot-na 326.76 APE67-dihe-in -72.22, 2.52 -57.29, -38.32 APE12-dist-na 9.949 APE11-dist-na 10.979 APE10-dist-na 7.519 APE9-dist-in 5.016 C491A,K641R None None XRAY 3.0 0.201 0.268 B 324 282 18 0 0 0 [[481, 759]] 1.0 2pzr TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UHNA 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.517 14.094 BLAminus -136.8, -167.33 56.16, 78.56 -101.45, 21.6 294.96, 102.9 -64.06, -30.14 in-in in 7.824 Saltbr-in 2.523 HRD-in -81.24, -42.19 65.24, 0.64 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.72, 22.85 APE9-dihe-in -103.03, 139.99 APE8-dihe-in -59.98, 123.73 APE8-rot-na 335.04 APE67-dihe-in -66.52, -14.98 -63.65, -42.1 APE12-dist-na 14.855 APE11-dist-na 10.903 APE10-dist-na 7.587 APE9-dist-in 4.884 N549H,E565A None None XRAY 2.909 0.26 0.311 A 324 282 14 0 0 0 [[481, 759]] 1.0 5uhn TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UHNB 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.513 14.023 BLAminus -136.33, -166.28 57.28, 77.94 -101.83, 20.57 295.09, 103.12 -64.81, -29.84 in-in in 7.663 Saltbr-in 2.464 HRD-in -80.51, -42.21 65.56, -0.07 in-in-out SNCiio in-out ActLoopNT-in 3.183 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -129.68, 22.67 APE9-dihe-in -103.05, 139.67 APE8-dihe-in -60.5, 125.01 APE8-rot-na 334.93 APE67-dihe-in -66.52, -14.36 -63.18, -41.76 APE12-dist-na 999.0 APE11-dist-na 10.814 APE10-dist-na 7.591 APE9-dist-in 4.817 N549H,E565A None None XRAY 2.909 0.26 0.311 B 324 269 27 0 0 11 [[481, 759]] 1.0 5uhn TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UGXA 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.657 14.049 BLAminus -131.13, -166.11 46.79, 87.05 -100.0, 21.89 288.47, 85.57 -64.83, -24.6 in-in in 7.609 Saltbr-in 2.992 HRD-in -78.16, -51.21 73.9, -1.28 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.33, 9.75 APE9-dihe-in -97.42, 138.88 APE8-dihe-in -59.74, 121.4 APE8-rot-na 334.26 APE67-dihe-in -70.7, -5.46 -65.5, -39.78 APE12-dist-na 15.029 APE11-dist-na 11.177 APE10-dist-na 7.458 APE9-dist-in 4.804 C491A,E565A None None XRAY 2.349 0.22 0.275 A 324 297 0 0 0 0 [[481, 759]] 1.0 5ugx TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UGXB 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.711 13.923 BLAminus -132.31, -170.71 52.3, 81.71 -96.0, 22.25 292.25, 87.7 -65.69, -25.27 in-in in 7.393 Saltbr-in 3.154 HRD-in -75.61, -53.17 73.28, -1.77 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.49, 16.52 APE9-dihe-in -100.17, 138.41 APE8-dihe-in -61.9, 122.99 APE8-rot-na 336.36 APE67-dihe-in -71.64, -5.56 -62.65, -38.67 APE12-dist-na 10.081 APE11-dist-na 10.766 APE10-dist-na 7.282 APE9-dist-in 4.828 C491A,E565A None None XRAY 2.349 0.22 0.275 B 324 282 15 0 0 10 [[481, 759]] 1.0 5ugx TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UI0B 462 765 821.0 ACP:802 ATPlike Inactive DFGin 6.542 14.213 BLAminus -136.98, -171.82 50.02, 76.91 -91.39, 21.0 284.06, 84.3 -70.34, -15.26 in-in in 7.243 Saltbr-in 2.959 HRD-in -80.63, -49.98 74.74, -10.37 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.5, 32.27 APE9-dihe-in -102.72, 128.27 APE8-dihe-in -51.42, 123.86 APE8-rot-na 328.96 APE67-dihe-in -69.39, -7.95 -60.08, -38.03 APE12-dist-na 14.784 APE11-dist-na 10.166 APE10-dist-na 7.606 APE9-dist-in 4.855 C491A,E565A None None XRAY 2.05 0.183 0.207 B 324 304 0 0 0 0 [[481, 759]] 1.0 5ui0 TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2Q0BA 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.538 14.238 BLAminus -137.67, -164.26 54.31, 72.63 -95.24, 25.26 285.39, 75.18 -61.23, -29.58 in-in in 7.243 Saltbr-in 2.723 HRD-in -79.58, -49.69 74.6, -12.22 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.18, 17.09 APE9-dihe-in -97.34, 129.87 APE8-dihe-in -55.33, 120.72 APE8-rot-na 329.23 APE67-dihe-in -73.97, -8.32 -57.44, -31.43 APE12-dist-na 9.977 APE11-dist-na 10.659 APE10-dist-na 7.369 APE9-dist-in 4.751 C491A,E565A None None XRAY 2.9 0.202 0.252 A 324 280 18 0 0 0 [[481, 759]] 1.0 2q0b TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2Q0BB 468 766 821.0 ACP:803 ATPlike Inactive DFGin 6.564 14.08 BLAminus -133.38, -173.77 65.46, 65.65 -91.7, 18.1 296.71, 72.83 -55.14, -29.53 in-in in 7.517 Saltbr-in 2.736 HRD-in -79.58, -50.53 70.04, -4.81 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.91, 21.68 APE9-dihe-in -99.61, 129.39 APE8-dihe-in -57.39, 112.59 APE8-rot-na 331.0 APE67-dihe-in -63.49, -9.98 -54.36, -36.94 APE12-dist-na 10.247 APE11-dist-na 10.839 APE10-dist-na 7.492 APE9-dist-in 4.906 C491A,E565A None None XRAY 2.9 0.202 0.252 B 324 282 17 0 0 0 [[481, 759]] 1.0 2q0b TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PY3A 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.395 14.125 BLAminus -132.09, -167.28 46.92, 77.9 -89.52, 28.18 287.97, 74.42 -64.92, -12.84 in-in in 7.278 Saltbr-in 2.643 HRD-in -69.15, -50.28 73.37, -7.92 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.57, 22.43 APE9-dihe-in -99.04, 131.25 APE8-dihe-in -52.37, 122.48 APE8-rot-na 325.05 APE67-dihe-in -72.14, -6.33 -51.92, -40.9 APE12-dist-na 9.95 APE11-dist-na 10.671 APE10-dist-na 7.386 APE9-dist-in 4.744 C491A,E565G None None XRAY 2.3 0.217 0.252 A 324 282 17 0 0 0 [[481, 759]] 1.0 2py3 TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PY3B 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.515 14.301 BLAminus -135.62, -170.09 51.9, 73.7 -89.2, 28.31 287.78, 75.56 -66.05, -13.03 in-in in 7.425 Saltbr-in 2.704 HRD-in -75.46, -47.46 71.33, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.61, 23.33 APE9-dihe-in -100.25, 127.63 APE8-dihe-in -52.55, 116.2 APE8-rot-na 325.69 APE67-dihe-in -68.53, -13.02 -47.88, -42.42 APE12-dist-na 10.066 APE11-dist-na 10.788 APE10-dist-na 7.419 APE9-dist-in 4.931 C491A,E565G None None XRAY 2.3 0.217 0.252 B 324 284 15 0 0 0 [[481, 759]] 1.0 2py3 TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6V6QA 466 765 821.0 ACP:901 ATPlike Inactive DFGin 6.894 13.908 BLAminus -137.26, -178.98 59.51, 71.9 -86.77, 13.5 292.04, 83.56 -59.04, -31.29 in-in in 7.246 Saltbr-in 3.289 HRD-in -72.64, -45.97 77.04, -16.81 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.45, 33.95 APE9-dihe-in -111.95, 129.79 APE8-dihe-in -53.65, 121.81 APE8-rot-na 327.05 APE67-dihe-in -70.56, -11.31 -58.83, -38.12 APE12-dist-na 14.264 APE11-dist-na 10.49 APE10-dist-na 7.77 APE9-dist-in 5.206 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 A 411 286 14 0 0 0 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6V6QB 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.809 14.125 BLAminus -136.61, -177.61 60.52, 69.31 -88.63, 15.47 290.7, 96.84 -63.12, -28.34 in-in in 7.343 Saltbr-in 3.295 HRD-in -73.07, -46.4 74.87, -14.44 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.84, 37.71 APE9-dihe-in -109.58, 130.31 APE8-dihe-in -50.87, 122.1 APE8-rot-na 324.14 APE67-dihe-in -69.97, -12.27 -61.49, -37.1 APE12-dist-na 14.135 APE11-dist-na 10.587 APE10-dist-na 8.065 APE9-dist-in 5.152 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 B 411 291 9 0 0 0 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6V6QD 467 765 821.0 ACP:901 ATPlike Inactive DFGin 6.936 13.989 BLAminus -136.56, -179.05 59.21, 72.83 -88.1, 16.16 292.51, 97.85 -58.15, -33.51 in-in in 7.38 Saltbr-in 3.334 HRD-in -71.81, -47.08 75.08, -13.84 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.25, 35.34 APE9-dihe-in -111.85, 128.58 APE8-dihe-in -53.13, 121.4 APE8-rot-na 327.69 APE67-dihe-in -69.26, -12.5 -60.26, -36.04 APE12-dist-na 999.0 APE11-dist-na 10.14 APE10-dist-na 7.433 APE9-dist-in 5.112 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 D 411 276 23 0 0 9 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8SWEA 468 765 821.0 GSH:802,WXQ:803 Allosteric,Type1 Inactive DFGin 6.584 14.421 BLAminus -150.2, -171.84 53.84, 62.99 -84.08, 24.59 289.03, 91.27 -65.33, -29.69 in-in in 7.667 Saltbr-in 3.478 HRD-in -78.34, -48.7 72.49, -5.74 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.6, 22.79 APE9-dihe-in -98.31, 134.63 APE8-dihe-in -56.2, 130.73 APE8-rot-na 335.99 APE67-dihe-in -78.04, -7.77 -69.42, -32.87 APE12-dist-na 10.083 APE11-dist-na 10.72 APE10-dist-na 7.381 APE9-dist-in 4.861 None None None XRAY 2.24 0.212 0.25 A 316 284 14 0 0 0 [[481, 759]] 1.0 8swe TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J96A 461 766 821.0 No_ligand No_ligand Inactive DFGin 6.898 14.243 BLAminus -129.08, -173.93 55.13, 75.05 -93.92, 17.08 285.11, 85.16 -64.81, -20.47 in-in in 7.291 Saltbr-in 3.106 HRD-in -86.2, -46.65 77.15, -15.27 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.58, 28.84 APE9-dihe-in -101.23, 126.83 APE8-dihe-in -54.36, 124.63 APE8-rot-na 330.34 APE67-dihe-in -70.0, -5.4 -59.65, -38.1 APE12-dist-na 14.933 APE11-dist-na 10.292 APE10-dist-na 7.443 APE9-dist-in 4.913 C491A,K659M None None XRAY 2.297 0.178 0.219 A 324 302 4 0 0 0 [[481, 759]] 1.0 4j96 TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
4J98A 461 764 821.0 No_ligand No_ligand Inactive DFGin 6.895 14.189 BLAminus -127.05, -173.93 55.52, 75.94 -94.55, 21.07 285.33, 84.3 -62.1, -22.56 in-in in 7.272 Saltbr-in 2.708 HRD-in -84.97, -48.15 77.1, -13.76 in-in-out SNCiio in-out ActLoopNT-in 2.892 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.08, 26.13 APE9-dihe-in -100.11, 126.32 APE8-dihe-in -52.05, 125.82 APE8-rot-na 328.58 APE67-dihe-in -66.67, -7.8 -60.08, -40.94 APE12-dist-na 15.203 APE11-dist-na 10.5 APE10-dist-na 7.501 APE9-dist-in 5.005 C491A,K659Q None None XRAY 2.307 0.19 0.234 A 324 304 0 0 0 0 [[481, 759]] 1.0 4j98 TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
1GJOA 467 764 821.0 No_ligand No_ligand Inactive DFGin 6.411 13.804 BLAminus -126.56, -173.35 57.91, 77.01 -93.75, 23.86 297.55, 90.05 -64.9, -30.61 in-in in 7.438 Saltbr-in 2.712 HRD-in -71.21, -44.77 68.97, -0.99 in-in-out SNCiio in-out ActLoopNT-in 2.896 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.53, 8.59 APE9-dihe-in -95.09, 140.9 APE8-dihe-in -65.99, 123.98 APE8-rot-na 24.92 APE67-dihe-in -67.17, -8.94 -56.08, -37.69 APE12-dist-na 9.89 APE11-dist-na 11.084 APE10-dist-na 7.484 APE9-dist-in 4.718 None None None XRAY 2.4 0.214 0.256 A 316 280 18 0 0 0 [[481, 759]] 1.0 1gjo TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
5UI0A 461 766 821.0 No_ligand No_ligand Inactive DFGin 6.705 14.36 BLAminus -135.62, -171.25 53.76, 73.69 -92.94, 20.04 285.17, 82.93 -70.08, -15.73 in-in in 7.271 Saltbr-in 2.866 HRD-in -79.02, -49.38 75.99, -10.91 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.85, 29.9 APE9-dihe-in -103.97, 128.06 APE8-dihe-in -51.81, 123.04 APE8-rot-na 328.88 APE67-dihe-in -69.55, -8.5 -59.7, -37.83 APE12-dist-na 14.893 APE11-dist-na 10.291 APE10-dist-na 7.544 APE9-dist-in 4.949 C491A,E565A None None XRAY 2.05 0.183 0.207 A 324 301 5 0 0 0 [[481, 759]] 1.0 5ui0 TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PSQA 468 765 821.0 No_ligand No_ligand Inactive DFGin 6.875 13.721 BLAminus -128.93, -172.72 52.18, 79.93 -92.08, 23.28 298.98, 73.8 -58.43, -25.99 in-in in 7.48 Saltbr-in 3.2 HRD-in -73.69, -49.43 74.12, -12.4 in-in-out SNCiio in-out ActLoopNT-in 2.946 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.29, 16.98 APE9-dihe-in -98.81, 130.21 APE8-dihe-in -53.9, 115.54 APE8-rot-na 323.02 APE67-dihe-in -67.54, -7.82 -55.22, -37.78 APE12-dist-na 10.124 APE11-dist-na 10.695 APE10-dist-na 7.21 APE9-dist-in 5.042 None None None XRAY 2.4 0.211 0.258 A 370 287 11 0 0 0 [[481, 759]] 1.0 2psq TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
2PSQB 467 766 821.0 No_ligand No_ligand Inactive DFGin 6.661 13.838 BLAminus -134.84, -175.34 56.99, 78.24 -93.68, 24.63 295.92, 77.95 -61.79, -34.13 in-in in 7.411 Saltbr-in 2.689 HRD-in -74.4, -46.06 70.25, -13.53 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.1, 12.51 APE9-dihe-in -92.24, 130.01 APE8-dihe-in -52.44, 120.68 APE8-rot-na 324.14 APE67-dihe-in -73.23, -4.23 -55.2, -38.33 APE12-dist-na 9.949 APE11-dist-na 10.675 APE10-dist-na 7.206 APE9-dist-in 5.022 None None None XRAY 2.4 0.211 0.258 B 370 286 14 0 0 0 [[481, 759]] 1.0 2psq TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
3B2TA 464 768 821.0 M33:1996 Type1 Inactive DFGin 6.43 14.187 BLAminus -134.3, -170.91 55.38, 73.11 -95.45, 19.5 296.12, 88.0 -64.8, -24.9 in-out in 7.374 Saltbr-out 3.738 HRD-in -75.34, -50.16 72.8, -10.74 out-in-out SNCoio in-out ActLoopNT-in 2.899 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.58, 14.29 APE9-dihe-in -98.64, 149.61 APE8-dihe-in -68.58, 112.73 APE8-rot-na 30.55 APE67-dihe-in -69.45, -7.24 -48.9, -42.7 APE12-dist-na 10.036 APE11-dist-na 10.988 APE10-dist-na 7.335 APE9-dist-in 4.705 A628T,E767Q None None XRAY 1.8 0.201 0.233 A 311 288 17 0 0 0 [[481, 759]] 1.0 3b2t TYR_FGFR2_HUMAN TYR 1.4e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
3B2TB 458 764 821.0 M33:1996 Type1 Inactive DFGin 6.509 14.155 BLAminus -136.01, -172.09 58.4, 72.93 -97.2, 21.29 297.11, 82.42 -63.1, -25.65 in-in in 7.376 Saltbr-in 2.752 HRD-in -77.18, -48.4 71.64, -8.98 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.99, 11.19 APE9-dihe-in -95.96, 149.11 APE8-dihe-in -68.88, 112.58 APE8-rot-na 32.44 APE67-dihe-in -68.01, -6.57 -48.48, -44.81 APE12-dist-na 9.998 APE11-dist-na 10.941 APE10-dist-na 7.274 APE9-dist-in 4.668 A628T,E767Q None None XRAY 1.8 0.201 0.233 B 311 287 20 0 0 0 [[481, 759]] 1.0 3b2t TYR_FGFR2_HUMAN TYR 1.4e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
7OZYAAA 467 762 821.0 47I:801 Type1 Inactive DFGin 6.618 14.218 BLAminus -128.08, -179.64 55.32, 74.91 -83.11, 15.08 289.1, 82.71 -52.3, -39.22 in-in in 7.535 Saltbr-in 2.859 HRD-in -77.89, -51.81 75.61, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.13, 18.52 APE9-dihe-in -94.81, 128.18 APE8-dihe-in -53.28, 119.61 APE8-rot-na 329.84 APE67-dihe-in -69.21, -9.08 -65.59, -32.88 APE12-dist-na 10.098 APE11-dist-na 10.628 APE10-dist-na 7.348 APE9-dist-in 4.663 None None None XRAY 2.28 0.243 0.296 AAA 303 281 15 0 0 0 [[481, 759]] 1.0 7ozy TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
7OZYBBB 467 762 821.0 47I:801 Type1 Inactive DFGin 6.525 14.222 BLAminus -125.86, 176.96 60.82, 78.39 -85.84, 17.43 287.27, 80.93 -50.81, -42.13 in-in in 7.411 Saltbr-in 2.925 HRD-in -87.72, -51.8 77.6, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.889 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.37, 16.38 APE9-dihe-in -94.48, 132.52 APE8-dihe-in -58.52, 125.58 APE8-rot-na 337.9 APE67-dihe-in -78.03, -12.35 -66.5, -32.9 APE12-dist-na 9.938 APE11-dist-na 10.807 APE10-dist-na 7.34 APE9-dist-in 4.825 None None None XRAY 2.28 0.243 0.296 BBB 303 278 18 0 0 0 [[481, 759]] 1.0 7ozy TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8H75A 467 765 821.0 KX0:1001 Type1 Inactive DFGin 7.213 14.585 BLAminus -154.63, 179.57 55.91, 54.1 -74.79, -3.2 274.96, 68.76 -58.48, -41.04 in-out in 7.417 Saltbr-out 4.811 HRD-out -96.67, 103.01 -67.39, -41.62 out-in-in SNCoii in-in ActLoopNT-in 3.141 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -162.98, 72.34 APE9-dihe-in -137.73, 148.36 APE8-dihe-in -71.99, 141.14 APE8-rot-na 343.8 APE67-dihe-in -63.34, -38.73 -70.52, -42.38 APE12-dist-na 13.018 APE11-dist-na 9.408 APE10-dist-na 7.3 APE9-dist-in 6.868 None PTR656 PTR656 XRAY 3.75 0.216 0.238 A 312 285 14 0 0 0 [[481, 759]] 1.0 8h75 TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8H75B 467 764 821.0 KX0:1001 Type1 Inactive DFGin 7.114 15.321 BLAminus -140.03, -170.55 50.75, 50.66 -73.91, -10.21 273.73, 91.58 -58.96, -39.4 in-out in 7.468 Saltbr-out 4.436 HRD-in -64.7, -43.07 75.93, -2.73 out-in-out SNCoio in-out ActLoopNT-in 3.383 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.7, -40.57 APE9-dihe-in -143.97, 156.51 APE8-dihe-in -61.01, 137.3 APE8-rot-na 23.2 APE67-dihe-in -61.01, -38.56 -64.05, -38.82 APE12-dist-na 14.092 APE11-dist-na 11.287 APE10-dist-na 7.446 APE9-dist-in 5.738 None PTR656 PTR656 XRAY 3.75 0.216 0.238 B 312 283 15 0 0 0 [[481, 759]] 1.0 8h75 TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8H75C 467 763 821.0 KX0:1001 Type1 Inactive DFGin 6.415 13.942 BLAminus -139.77, -171.25 51.94, 53.82 -68.52, 7.4 288.78, 82.18 -59.71, -35.71 in-in in 7.763 Saltbr-in 2.579 HRD-in -64.69, -38.41 67.2, 3.13 in-out-out SNCioo out-out ActLoopNT-out 3.788 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -86.06, 23.54 APE9-dihe-in -123.01, 141.76 APE8-dihe-in -64.83, 140.92 APE8-rot-na 351.7 APE67-dihe-in -63.43, -39.45 -65.53, -40.64 APE12-dist-na 10.784 APE11-dist-na 10.944 APE10-dist-na 7.514 APE9-dist-in 5.382 None PTR656 PTR656 XRAY 3.75 0.216 0.238 C 312 275 22 0 0 6 [[481, 759]] 1.0 8h75 TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8H75D 467 764 821.0 KX0:1001 Type1 Inactive DFGin 6.719 14.006 BLAminus -145.79, -169.72 52.31, 64.06 -85.42, 2.67 285.45, 103.44 -59.5, -38.29 in-out in 7.69 Saltbr-out 4.357 HRD-in -66.94, -45.53 78.8, 0.63 out-in-out SNCoio in-out ActLoopNT-in 3.389 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 55.78, 41.43 APE9-dihe-in -144.13, 151.96 APE8-dihe-in -70.01, 128.38 APE8-rot-na 29.85 APE67-dihe-in -54.94, -35.54 -65.88, -42.6 APE12-dist-na 10.994 APE11-dist-na 11.053 APE10-dist-na 8.829 APE9-dist-in 5.759 None PTR656 PTR656 XRAY 3.75 0.216 0.238 D 312 277 21 0 0 4 [[481, 759]] 1.0 8h75 TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6LVKA 468 766 821.0 EVC:801 Type1 Inactive DFGin 6.619 14.543 BLAminus -141.93, -174.02 55.34, 76.62 -90.82, 24.34 285.38, 77.37 -62.85, -30.59 in-in in 7.73 Saltbr-in 2.684 HRD-in -81.18, -49.18 75.66, -4.17 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.17, 17.9 APE9-dihe-in -89.66, 132.44 APE8-dihe-in -56.46, 117.97 APE8-rot-na 336.42 APE67-dihe-in -71.4, -11.53 -57.14, -41.35 APE12-dist-na 10.045 APE11-dist-na 10.809 APE10-dist-na 7.443 APE9-dist-in 4.936 None PTR561 PTR561 XRAY 2.29 0.206 0.247 A 313 288 11 0 0 0 [[481, 759]] 1.0 6lvk TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6LVKB 468 765 821.0 EVC:801 Type1 Inactive DFGin 6.424 14.429 BLAminus -142.63, -167.55 46.22, 79.21 -86.53, 20.35 286.19, 75.54 -62.27, -23.76 in-in in 7.449 Saltbr-in 2.644 HRD-in -74.06, -49.98 75.98, -4.75 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.0, 16.4 APE9-dihe-in -92.04, 132.11 APE8-dihe-in -55.72, 122.03 APE8-rot-na 331.04 APE67-dihe-in -82.5, -6.39 -64.61, -25.66 APE12-dist-na 10.161 APE11-dist-na 10.85 APE10-dist-na 7.496 APE9-dist-in 4.862 None PTR561 PTR561 XRAY 2.29 0.206 0.247 B 313 286 12 0 0 0 [[481, 759]] 1.0 6lvk TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6LVLA 468 766 821.0 EVL:802 Type1 Inactive DFGin 6.609 14.53 BLAminus -146.15, -175.25 63.31, 72.06 -88.46, 19.6 283.4, 82.21 -53.64, -28.47 in-in in 7.721 Saltbr-in 2.632 HRD-in -74.18, -46.26 67.97, -0.94 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.16, 11.22 APE9-dihe-in -81.14, 133.04 APE8-dihe-in -57.2, 120.46 APE8-rot-na 339.92 APE67-dihe-in -68.23, -11.94 -62.32, -43.83 APE12-dist-na 10.163 APE11-dist-na 10.953 APE10-dist-na 7.536 APE9-dist-in 4.894 None None None XRAY 2.98 0.204 0.251 A 313 288 11 0 0 0 [[481, 759]] 1.0 6lvl TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6LVLB 468 765 821.0 EVL:804 Type1 Inactive DFGin 6.504 14.379 BLAminus -137.97, -168.86 49.59, 89.79 -98.61, 21.56 282.72, 81.93 -60.4, -25.9 in-in in 7.476 Saltbr-in 2.773 HRD-in -74.99, -51.02 79.49, -6.99 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.2, 10.06 APE9-dihe-in -85.19, 131.23 APE8-dihe-in -58.17, 126.23 APE8-rot-na 336.1 APE67-dihe-in -79.35, -7.86 -72.73, -22.05 APE12-dist-na 10.031 APE11-dist-na 10.842 APE10-dist-na 7.447 APE9-dist-in 4.847 None None None XRAY 2.98 0.204 0.251 B 313 286 12 0 0 0 [[481, 759]] 1.0 6lvl TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
3RI1B 468 766 821.0 3RH:1 Type1 Inactive DFGin 6.669 14.168 BLAminus -125.05, -168.18 44.8, 79.48 -91.34, 24.45 292.18, 85.49 -61.68, -38.04 in-in in 7.681 Saltbr-in 2.714 HRD-in -78.4, -46.06 72.66, -13.3 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.45, 15.65 APE9-dihe-in -96.94, 132.02 APE8-dihe-in -54.97, 122.14 APE8-rot-na 331.98 APE67-dihe-in -73.55, -6.33 -62.74, -38.58 APE12-dist-na 10.023 APE11-dist-na 10.84 APE10-dist-na 7.241 APE9-dist-in 5.005 None None None XRAY 2.1 0.216 0.247 B 313 283 16 0 0 0 [[481, 759]] 1.0 3ri1 TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
1OECA 467 765 821.0 AA2:789 Type1 Inactive DFGin 6.387 13.79 BLAminus -124.86, -174.89 57.86, 79.24 -96.93, 23.45 302.8, 91.55 -64.89, -25.19 in-in in 7.359 Saltbr-in 2.798 HRD-in -70.07, -47.99 69.27, 1.07 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.98, 11.44 APE9-dihe-in -98.33, 142.87 APE8-dihe-in -64.53, 124.86 APE8-rot-na 24.49 APE67-dihe-in -66.61, -6.07 -58.62, -38.0 APE12-dist-na 10.059 APE11-dist-na 11.136 APE10-dist-na 7.546 APE9-dist-in 4.768 None None None XRAY 2.4 0.211 0.285 A 316 281 18 0 0 0 [[481, 759]] 1.0 1oec TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8SWEB 468 767 821.0 WXQ:804 Type1 Inactive DFGin 6.362 14.39 BLAminus -138.39, -167.44 55.86, 63.6 -85.72, 22.79 292.14, 86.9 -64.13, -34.28 in-out in 7.84 Saltbr-out 3.615 HRD-in -78.85, -51.07 77.2, -7.67 out-in-out SNCoio in-out ActLoopNT-in 3.023 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.42, 18.52 APE9-dihe-in -97.67, 132.33 APE8-dihe-in -56.79, 133.06 APE8-rot-na 333.48 APE67-dihe-in -69.86, -7.28 -72.44, -38.73 APE12-dist-na 10.101 APE11-dist-na 10.797 APE10-dist-na 7.318 APE9-dist-in 4.892 None None None XRAY 2.24 0.212 0.25 B 316 288 12 0 0 0 [[481, 759]] 1.0 8swe TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
7KIAA 467 764 821.0 WFD:801 Type1 Inactive DFGin 6.907 14.585 BLAminus -132.24, -172.32 57.59, 74.96 -99.72, 18.32 278.92, 79.54 -50.95, -35.45 in-in in 7.569 Saltbr-in 2.776 HRD-in -81.84, -48.19 75.32, -4.56 in-in-out SNCiio in-out ActLoopNT-in 2.907 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.81, 20.05 APE9-dihe-in -94.44, 131.06 APE8-dihe-in -58.4, 124.3 APE8-rot-na 334.14 APE67-dihe-in -73.93, -12.14 -62.31, -36.95 APE12-dist-na 9.889 APE11-dist-na 10.634 APE10-dist-na 7.311 APE9-dist-in 4.784 V564F None None XRAY 2.22 0.2 0.223 A 308 287 11 0 0 0 [[481, 759]] 1.0 7kia TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
7KIAB 467 767 821.0 WFD:801 Type1 Inactive DFGin 6.992 14.509 BLAminus -132.54, -177.3 64.71, 67.38 -94.95, 24.82 285.24, 66.73 -55.57, -35.57 in-in in 7.506 Saltbr-in 2.868 HRD-in -82.16, -48.97 81.36, -8.74 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.27, 21.92 APE9-dihe-in -96.64, 130.19 APE8-dihe-in -51.06, 117.36 APE8-rot-na 325.83 APE67-dihe-in -72.33, -8.1 -58.88, -42.34 APE12-dist-na 9.986 APE11-dist-na 10.74 APE10-dist-na 7.352 APE9-dist-in 4.86 V564F None None XRAY 2.22 0.2 0.223 B 308 288 13 0 0 0 [[481, 759]] 1.0 7kia TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
7KIEA 466 766 821.0 WF7:801 Type1 Inactive DFGin 6.977 14.848 BLAminus -131.39, -169.16 54.75, 74.84 -95.86, 20.26 282.29, 75.53 -45.07, -46.66 in-in in 7.611 Saltbr-in 3.048 HRD-in -91.29, -46.71 82.94, -9.97 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -125.11, 21.7 APE9-dihe-in -95.02, 131.64 APE8-dihe-in -52.4, 118.95 APE8-rot-na 324.83 APE67-dihe-in -75.99, -13.6 -53.13, -38.79 APE12-dist-na 10.033 APE11-dist-na 10.705 APE10-dist-na 7.483 APE9-dist-in 4.839 V564F None None XRAY 2.47 0.202 0.229 A 308 291 10 0 0 0 [[481, 759]] 1.0 7kie TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
7KIEB 466 767 821.0 WF7:801 Type1 Inactive DFGin 7.035 14.809 BLAminus -137.38, -176.99 66.42, 65.65 -89.69, 13.43 284.31, 71.08 -48.41, -38.08 in-in in 7.448 Saltbr-in 3.232 HRD-in -77.26, -55.81 80.7, -9.45 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.89, 17.38 APE9-dihe-in -97.25, 125.97 APE8-dihe-in -52.01, 125.72 APE8-rot-na 329.53 APE67-dihe-in -76.39, -7.41 -69.78, -34.58 APE12-dist-na 10.09 APE11-dist-na 10.736 APE10-dist-na 7.332 APE9-dist-in 4.938 V564F None None XRAY 2.47 0.202 0.229 B 308 292 10 0 0 0 [[481, 759]] 1.0 7kie TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3BA 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.161 13.792 BLAminus -144.89, -177.58 62.94, 96.35 -110.18, 24.57 301.57, 159.93 -61.44, -28.3 in-in in 7.866 Saltbr-in 2.964 HRD-in -87.0, -57.18 84.04, -4.97 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.51, 11.01 APE9-dihe-in -96.95, 136.95 APE8-dihe-in -62.98, 123.95 APE8-rot-na 335.72 APE67-dihe-in -70.54, -2.64 -63.47, -42.68 APE12-dist-na 999.0 APE11-dist-na 10.859 APE10-dist-na 7.224 APE9-dist-in 4.817 D650V None None XRAY 2.23 0.292 0.312 A 324 279 19 0 0 5 [[481, 759]] 1.0 8w3b TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3BB 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.18 13.86 BLAminus -144.53, -178.27 63.36, 96.56 -110.32, 24.83 301.28, 159.37 -61.06, -28.93 in-in in 7.884 Saltbr-in 2.965 HRD-in -86.57, -57.01 84.08, -5.72 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.04, 13.83 APE9-dihe-in -96.67, 136.92 APE8-dihe-in -63.18, 124.36 APE8-rot-na 337.68 APE67-dihe-in -70.88, -2.28 -62.39, -43.26 APE12-dist-na 999.0 APE11-dist-na 10.744 APE10-dist-na 7.23 APE9-dist-in 4.821 D650V None None XRAY 2.23 0.292 0.312 B 324 278 20 0 0 11 [[481, 759]] 1.0 8w3b TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3BC 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.13 13.838 BLAminus -145.32, -177.36 62.67, 96.38 -110.43, 24.64 301.15, 160.25 -61.18, -28.47 in-in in 7.826 Saltbr-in 2.968 HRD-in -87.03, -56.85 84.22, -5.5 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.46, 11.6 APE9-dihe-in -97.28, 136.65 APE8-dihe-in -63.45, 123.79 APE8-rot-na 336.35 APE67-dihe-in -70.29, -2.36 -62.67, -42.99 APE12-dist-na 999.0 APE11-dist-na 10.847 APE10-dist-na 7.207 APE9-dist-in 4.846 D650V None None XRAY 2.23 0.292 0.312 C 324 294 4 0 0 4 [[481, 759]] 1.0 8w3b TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3BD 465 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.111 13.867 BLAminus -145.2, -177.75 62.8, 96.65 -110.44, 24.68 301.04, 159.7 -61.39, -28.62 in-in in 7.857 Saltbr-in 2.962 HRD-in -87.13, -57.13 84.17, -5.75 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.01, 12.17 APE9-dihe-in -96.72, 136.82 APE8-dihe-in -63.08, 124.37 APE8-rot-na 337.6 APE67-dihe-in -71.49, -1.84 -62.33, -43.32 APE12-dist-na 999.0 APE11-dist-na 10.817 APE10-dist-na 7.235 APE9-dist-in 4.829 D650V None None XRAY 2.23 0.292 0.312 D 324 280 20 0 0 11 [[481, 759]] 1.0 8w3b TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3DA 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.885 13.915 BLAminus -147.5, -176.54 60.37, 88.47 -102.26, 25.1 300.92, 154.4 -57.13, -34.04 in-in in 7.825 Saltbr-in 2.797 HRD-in -84.9, -54.51 77.26, 0.33 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.98, 12.82 APE9-dihe-in -97.28, 131.96 APE8-dihe-in -62.75, 115.5 APE8-rot-na 335.68 APE67-dihe-in -74.05, -8.17 -56.13, -41.02 APE12-dist-na 10.06 APE11-dist-na 11.173 APE10-dist-na 7.386 APE9-dist-in 4.984 N549K,D650V None None XRAY 2.04 0.22 0.25 A 324 298 0 0 0 0 [[481, 759]] 1.0 8w3d TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3DB 463 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.832 14.017 BLAminus -148.34, -176.74 60.99, 88.17 -102.41, 24.87 299.72, 154.97 -58.18, -33.84 in-in in 7.787 Saltbr-in 2.765 HRD-in -83.96, -54.88 76.41, -0.28 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.87, 19.37 APE9-dihe-in -95.98, 132.29 APE8-dihe-in -61.49, 116.39 APE8-rot-na 335.8 APE67-dihe-in -74.83, -7.73 -55.74, -41.43 APE12-dist-na 10.807 APE11-dist-na 10.914 APE10-dist-na 7.465 APE9-dist-in 4.97 N549K,D650V None None XRAY 2.04 0.22 0.25 B 324 286 16 0 0 7 [[481, 759]] 1.0 8w3d TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3DC 467 766 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.855 13.9 BLAminus -147.64, -176.09 60.07, 88.49 -102.13, 25.05 300.63, 154.01 -57.64, -33.63 in-in in 7.772 Saltbr-in 2.793 HRD-in -84.16, -54.95 77.08, 0.92 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.76, 14.01 APE9-dihe-in -96.42, 131.36 APE8-dihe-in -63.38, 115.02 APE8-rot-na 334.88 APE67-dihe-in -73.92, -8.44 -56.07, -40.69 APE12-dist-na 10.113 APE11-dist-na 11.132 APE10-dist-na 7.426 APE9-dist-in 4.986 N549K,D650V None None XRAY 2.04 0.22 0.25 C 324 300 0 0 0 0 [[481, 759]] 1.0 8w3d TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W3DD 463 765 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.812 14.007 BLAminus -147.99, -176.89 61.0, 88.35 -102.2, 24.75 299.43, 154.83 -57.77, -34.3 in-in in 7.773 Saltbr-in 2.759 HRD-in -84.08, -54.96 76.09, 0.5 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.21, 21.5 APE9-dihe-in -95.42, 132.82 APE8-dihe-in -60.81, 115.91 APE8-rot-na 335.81 APE67-dihe-in -74.61, -8.25 -55.74, -40.98 APE12-dist-na 10.799 APE11-dist-na 10.925 APE10-dist-na 7.589 APE9-dist-in 4.967 N549K,D650V None None XRAY 2.04 0.22 0.25 D 324 296 7 0 0 2 [[481, 759]] 1.0 8w3d TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6AGXA 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.385 13.771 BLAminus -135.61, -178.23 50.32, 94.72 -100.36, 28.49 297.32, 121.17 -57.47, -52.54 in-out in 8.0 Saltbr-out 3.657 HRD-in -93.88, -57.68 78.68, 6.68 out-in-in SNCoii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.5, 54.14 APE9-dihe-in -114.81, 139.22 APE8-dihe-in -71.75, 130.63 APE8-rot-na 345.91 APE67-dihe-in -76.18, -12.01 -73.34, -35.43 APE12-dist-na 13.53 APE11-dist-na 9.065 APE10-dist-na 7.568 APE9-dist-in 4.596 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 A 298 285 13 0 0 5 [[481, 759]] 1.0 6agx TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6AGXB 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.405 14.025 BLAminus -135.35, -176.95 51.01, 93.04 -100.6, 27.53 298.31, 119.25 -60.39, -50.86 in-out in 7.961 Saltbr-out 4.38 HRD-in -94.17, -57.95 78.91, 4.09 out-in-out SNCoio in-out ActLoopNT-in 2.949 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.86, 49.42 APE9-dihe-in -113.92, 143.72 APE8-dihe-in -70.47, 130.2 APE8-rot-na 344.64 APE67-dihe-in -74.99, -12.99 -75.16, -33.86 APE12-dist-na 14.503 APE11-dist-na 9.856 APE10-dist-na 7.732 APE9-dist-in 4.697 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 B 298 298 0 0 0 0 [[481, 759]] 1.0 6agx TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6AGXC 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.39 13.803 BLAminus -136.28, -175.68 48.02, 94.4 -101.25, 28.5 296.6, 120.3 -58.43, -51.67 in-out in 7.916 Saltbr-out 3.662 HRD-in -93.94, -57.46 79.08, 5.82 out-in-in SNCoii in-in ActLoopNT-in 2.951 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.39, 66.84 APE9-dihe-in -120.25, 138.55 APE8-dihe-in -72.11, 130.82 APE8-rot-na 346.01 APE67-dihe-in -76.61, -11.72 -72.7, -35.99 APE12-dist-na 14.141 APE11-dist-na 9.191 APE10-dist-na 7.7 APE9-dist-in 4.7 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 C 298 284 14 0 0 5 [[481, 759]] 1.0 6agx TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6AGXD 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.355 13.94 BLAminus -136.3, -175.46 49.29, 93.64 -101.17, 27.37 298.51, 119.67 -59.92, -50.84 in-out in 7.975 Saltbr-out 3.689 HRD-in -94.2, -57.48 79.52, 3.16 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.04, 47.47 APE9-dihe-in -113.88, 141.66 APE8-dihe-in -70.17, 130.94 APE8-rot-na 346.46 APE67-dihe-in -73.96, -13.6 -74.55, -33.23 APE12-dist-na 14.283 APE11-dist-na 9.82 APE10-dist-na 7.608 APE9-dist-in 4.719 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 D 298 298 0 0 0 0 [[481, 759]] 1.0 6agx TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
3RI1A 468 765 821.0 3RH:2 Type1.5_Back Inactive DFGin 6.832 14.17 BLAminus -123.23, -170.67 54.24, 75.33 -95.71, 30.48 294.51, 86.16 -72.01, -31.85 in-in in 7.756 Saltbr-in 2.712 HRD-in -81.62, -48.44 74.58, -5.16 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.86, 17.26 APE9-dihe-in -94.17, 130.86 APE8-dihe-in -56.98, 120.47 APE8-rot-na 333.82 APE67-dihe-in -73.48, -11.98 -59.18, -36.04 APE12-dist-na 9.865 APE11-dist-na 10.71 APE10-dist-na 7.382 APE9-dist-in 4.842 None None None XRAY 2.1 0.216 0.247 A 313 285 13 0 0 0 [[481, 759]] 1.0 3ri1 TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W38A 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.884 13.939 BLAminus -141.73, -172.44 58.43, 85.09 -99.65, 33.03 296.5, 153.04 -60.44, -42.96 in-in in 7.716 Saltbr-in 2.73 HRD-in -67.46, -57.27 77.66, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.69, 6.19 APE9-dihe-in -92.48, 138.52 APE8-dihe-in -67.31, 130.89 APE8-rot-na 342.55 APE67-dihe-in -76.49, 2.73 -63.26, -44.89 APE12-dist-na 9.938 APE11-dist-na 10.863 APE10-dist-na 7.187 APE9-dist-in 4.84 N549D,D650V None None XRAY 2.6 0.337 0.359 A 324 298 0 0 0 0 [[481, 759]] 1.0 8w38 TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W38B 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.917 13.867 BLAminus -141.61, -172.11 58.71, 84.88 -99.53, 33.01 296.86, 151.72 -60.67, -42.8 in-in in 7.677 Saltbr-in 2.736 HRD-in -66.89, -57.79 77.67, 7.38 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.73, 7.76 APE9-dihe-in -92.14, 138.79 APE8-dihe-in -66.97, 130.73 APE8-rot-na 341.51 APE67-dihe-in -76.67, 2.98 -63.37, -44.91 APE12-dist-na 9.766 APE11-dist-na 10.751 APE10-dist-na 7.194 APE9-dist-in 4.826 N549D,D650V None None XRAY 2.6 0.337 0.359 B 324 288 10 0 0 6 [[481, 759]] 1.0 8w38 TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W38C 465 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.905 14.001 BLAminus -141.73, -172.23 58.36, 85.55 -99.69, 32.51 297.47, 150.87 -60.14, -43.03 in-in in 7.766 Saltbr-in 2.733 HRD-in -67.3, -57.38 78.5, 5.79 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.74, 8.72 APE9-dihe-in -90.56, 139.47 APE8-dihe-in -66.09, 130.7 APE8-rot-na 342.51 APE67-dihe-in -75.82, 2.85 -65.85, -41.6 APE12-dist-na 999.0 APE11-dist-na 10.65 APE10-dist-na 7.238 APE9-dist-in 4.776 N549D,D650V None None XRAY 2.6 0.337 0.359 C 324 289 11 0 0 11 [[481, 759]] 1.0 8w38 TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W38D 467 764 821.0 TZ0:800 Type1.5_Back Inactive DFGin 5.958 13.994 BLAminus -141.63, -172.13 58.59, 85.21 -99.57, 33.16 297.38, 150.22 -60.22, -43.6 in-in in 7.782 Saltbr-in 2.764 HRD-in -66.88, -57.89 78.41, 5.63 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.9, 7.03 APE9-dihe-in -91.06, 139.7 APE8-dihe-in -66.27, 130.75 APE8-rot-na 343.36 APE67-dihe-in -75.84, 2.91 -65.4, -41.85 APE12-dist-na 999.0 APE11-dist-na 10.75 APE10-dist-na 7.22 APE9-dist-in 4.794 N549D,D650V None None XRAY 2.6 0.337 0.359 D 324 271 27 0 0 11 [[481, 759]] 1.0 8w38 TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8E1XA 468 762 821.0 U9P:801 Type1 Inactive DFGin 5.029 12.823 BLAplus -132.17, 165.27 55.8, 54.52 -100.25, -11.66 52.62, 78.71 -98.93, 9.55 in-in in 8.036 Saltbr-in 2.644 HRD-in -82.17, -50.15 76.34, -11.07 in-out-out SNCioo out-out ActLoopNT-out 8.222 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -128.31, 147.09 APE9-dihe-in -97.44, 99.33 APE8-dihe-out -63.81, -11.62 APE8-rot-na 338.3 APE67-dihe-in -73.9, -4.36 -70.48, -21.94 APE12-dist-na 14.85 APE11-dist-na 18.906 APE10-dist-na 16.364 APE9-dist-out 11.465 None PTR561,PTR586 PTR561,PTR586 XRAY 2.68 0.226 0.272 A 330 290 5 0 0 5 [[481, 759]] 1.0 8e1x TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8E1XB 467 765 821.0 U9P:801 Type1 Inactive DFGin 5.691 12.618 BLAplus -131.15, 165.03 56.01, 52.0 -100.91, -14.67 45.9, 85.31 -101.29, 8.07 in-in in 8.079 Saltbr-in 3.074 HRD-in -82.51, -51.1 78.17, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.514 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -131.92, 152.55 APE9-dihe-in -96.57, 103.24 APE8-dihe-out -60.48, -10.56 APE8-rot-na 339.07 APE67-dihe-in -76.23, -2.9 -70.07, -24.1 APE12-dist-na 14.925 APE11-dist-na 19.439 APE10-dist-na 17.481 APE9-dist-out 11.322 None PTR561,PTR586 PTR561,PTR586 XRAY 2.68 0.226 0.272 B 330 293 6 0 0 2 [[481, 759]] 1.0 8e1x TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8STGA 461 764 821.0 WCJ:801 Type1 Inactive DFGin 5.59 12.888 BLAplus -145.36, 157.52 90.77, 4.11 -67.5, -2.28 57.4, 70.91 -126.28, 999.0 in-out in 8.184 Saltbr-out 4.606 HRD-out -102.42, 117.61 -61.0, -55.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -15.95 APE9-dihe-in -134.91, 146.08 APE8-dihe-in -92.36, 82.18 APE8-rot-na 24.23 APE67-dihe-in -66.95, -23.69 -61.29, -38.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.907 None None None XRAY 3.79 0.307 0.311 A 317 277 27 0 0 17 [[481, 759]] 1.0 8stg TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
9U3NA 461 764 821.0 A1ENT:801 Type1 Inactive DFGin 5.818 12.949 BLAplus -102.48, 156.56 123.79, -13.39 -63.25, -8.77 52.43, 90.85 -152.53, 999.0 in-out in 8.178 Saltbr-out 4.631 HRD-out -98.51, 122.94 -65.62, -59.12 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.33, 167.8 APE9-dihe-in -100.91, 125.49 APE8-dihe-in -74.9, 91.59 APE8-rot-na 32.92 APE67-dihe-in -76.06, -19.15 -78.78, -31.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.66 V564F None None XRAY 3.25 0.283 0.342 A 311 276 28 0 0 15 [[481, 759]] 1.0 9u3n TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W2XA 458 765 821.0 A1AFR:60801 Type1.5_Back Inactive DFGin 5.186 13.347 BLAplus -120.4, 170.08 47.84, 47.71 -101.14, -15.65 62.51, 79.97 -87.59, -18.95 in-in in 8.011 Saltbr-in 2.948 HRD-in -69.21, -58.65 84.1, -5.97 in-out-out SNCioo out-out ActLoopNT-out 8.558 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.12, 147.0 APE9-dihe-in -116.78, 92.64 APE8-dihe-out -53.69, -17.45 APE8-rot-na 330.1 APE67-dihe-in -71.44, -10.68 -63.08, -26.44 APE12-dist-na 19.353 APE11-dist-na 21.562 APE10-dist-na 17.572 APE9-dist-out 11.588 None None None XRAY 2.98 0.211 0.237 A 324 304 4 0 0 0 [[481, 759]] 1.0 8w2x TYR_FGFR2_HUMAN TYR 6.2e-104 352.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8W2XB 458 765 821.0 A1AFR:60801 Type1.5_Back Inactive DFGin 5.172 13.672 BLAplus -120.88, 172.87 46.97, 47.43 -101.96, -10.72 62.07, 80.77 -85.12, -16.26 in-in in 8.256 Saltbr-in 3.578 HRD-in -69.81, -58.19 83.73, -4.52 in-out-out SNCioo out-out ActLoopNT-out 7.566 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.55, 151.04 APE9-dihe-in -117.66, 89.73 APE8-dihe-out -57.08, -16.9 APE8-rot-na 336.97 APE67-dihe-in -70.95, -11.38 -63.76, -26.5 APE12-dist-na 19.294 APE11-dist-na 21.709 APE10-dist-na 18.148 APE9-dist-out 11.385 None None None XRAY 2.98 0.211 0.237 B 324 291 17 0 0 3 [[481, 759]] 1.0 8w2x TYR_FGFR2_HUMAN TYR 6.2e-104 352.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8U1FA 460 764 821.0 UIM:802 Type1.5_Back Inactive DFGin 5.799 12.234 BLAplus -115.66, -167.23 57.04, 20.36 -74.9, -7.44 38.26, 84.93 19.48, 999.0 in-out in 7.802 Saltbr-out 4.269 HRD-out -85.43, 135.13 -70.56, -48.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -64.66 APE9-dihe-in -61.23, 136.11 APE8-dihe-in -91.89, 60.04 APE8-rot-na 32.99 APE67-dihe-in -62.46, -7.58 -55.89, -38.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.28 None None None XRAY 3.33 0.269 0.295 A 316 276 29 0 0 17 [[481, 759]] 1.0 8u1f TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
6V6QC 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.766 13.643 BLBminus -136.89, -177.89 59.28, 74.24 -85.91, -161.66 300.29, 95.93 81.23, -12.62 in-in in 7.463 Saltbr-in 3.314 HRD-in -72.01, -47.4 74.74, -13.46 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.47, 28.67 APE9-dihe-in -111.04, 128.94 APE8-dihe-in -52.92, 121.96 APE8-rot-na 327.46 APE67-dihe-in -69.24, -12.82 -58.84, -37.31 APE12-dist-na 999.0 APE11-dist-na 10.498 APE10-dist-na 7.431 APE9-dist-in 5.088 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 C 411 279 21 0 0 11 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8U1FB 472 765 821.0 UIM:802 Type1.5_Back Inactive DFGin 6.244 12.702 None -124.83, 24.9 -143.72, 116.95 -174.75, 141.2 47.25, 98.48 -120.17, -141.34 in-out in 7.179 Saltbr-out 5.47 HRD-out -91.63, 125.64 -83.89, -44.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.43 APE8-dihe-in -82.13, 67.06 APE8-rot-na 35.42 APE67-dihe-in -61.84, -12.32 -56.83, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.201 None None None XRAY 3.33 0.269 0.295 B 316 268 26 0 0 16 [[481, 759]] 1.0 8u1f TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
8STGB 472 765 821.0 WCJ:801 Type1.5_Back Inactive DFGin 5.748 12.473 None -146.69, 51.17 -166.05, 99.26 -159.05, 129.25 42.24, 92.9 -129.91, 121.06 in-out in 7.518 Saltbr-out 4.961 HRD-out -109.82, 96.26 -71.43, -48.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.23, -15.79 APE9-dihe-in -138.41, 153.88 APE8-dihe-in -76.95, 77.58 APE8-rot-na 30.06 APE67-dihe-in -68.25, -27.71 -60.57, -41.19 APE12-dist-na 23.596 APE11-dist-na 24.226 APE10-dist-na 21.813 APE9-dist-in 7.303 None None None XRAY 3.79 0.307 0.311 B 317 274 20 0 0 10 [[481, 759]] 1.0 8stg TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
9U3NB 470 764 821.0 A1ENT:801 Type1.5_Back Inactive DFGin 5.761 12.952 None -150.15, 37.07 -124.69, 18.17 -79.98, -34.12 48.54, 88.69 -70.14, 999.0 in-in in 7.94 Saltbr-in 3.377 HRD-out -109.06, 108.36 -99.86, 137.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -159.89, 170.93 APE9-dihe-in -97.33, 137.9 APE8-dihe-in -78.65, 61.34 APE8-rot-na 34.6 APE67-dihe-in -58.88, -28.65 -55.23, -53.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.659 V564F None None XRAY 3.25 0.283 0.342 B 311 272 23 0 0 13 [[481, 759]] 1.0 9u3n TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2

TYR_FGFR2 (Fibroblast growth factor receptor 2)

Total number of chains: 99
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 88 88.9% AF-P21802-K1A
DFGin BLAplus 7 7.1% 8W2XA
DFGin None 3 3.0% 8STGB
DFGin BLBminus 1 1.0% 6V6QC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR2_HUMAN 2PVFA P21802 467 765 821.0 ACP:60300 ATPlike Active DFGin 6.048 13.821 BLAminus -138.88, -175.17 54.67, 80.46 -90.11, 24.33 291.08, 76.38 -54.38, -36.38 in-in in 7.913 Saltbr-in 2.769 HRD-in -85.37, -48.4 70.03, 0.26 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.94, 115.27 APE9-dihe-in -125.87, 160.91 APE8-dihe-in -74.41, 68.1 APE8-rot-na 35.92 APE67-dihe-in -70.82, -9.54 -47.44, -41.99 APE12-dist-na 15.14 APE11-dist-na 11.649 APE10-dist-na 11.604 APE9-dist-in 7.168 C491A PTR586,PTR656,PTR657 PTR586,PTR656,PTR657 XRAY 1.8 0.251 0.265 A 334 288 11 0 0 0 [[481, 759]] 1.0 2pvf Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 3CLYA P21802 468 772 821.0 ACP:61803 ATPlike Active DFGin 6.229 14.183 BLAminus -138.78, -172.76 51.4, 79.79 -91.29, 32.46 290.47, 75.81 -61.86, -29.26 in-in in 7.661 Saltbr-in 2.621 HRD-in -89.86, -45.92 68.93, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.79, 139.96 APE9-dihe-in -131.36, 152.18 APE8-dihe-in -76.17, 66.16 APE8-rot-na 37.1 APE67-dihe-in -66.78, -6.73 -47.95, -40.48 APE12-dist-na 13.253 APE11-dist-na 10.402 APE10-dist-na 11.097 APE9-dist-in 6.913 C491A PTR656,PTR657 PTR656,PTR657 XRAY 2.0 0.216 0.247 A 334 291 14 0 0 0 [[481, 759]] 1.0 3cly Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5EG3A P21802 466 774 821.0 ACP:60801 ATPlike Active DFGin 6.034 13.825 BLAminus -138.71, -166.61 47.53, 87.44 -100.17, 28.73 285.85, 82.29 -77.8, -14.99 in-in in 8.045 Saltbr-in 2.941 HRD-in -83.82, -45.21 62.18, 9.75 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.56, 121.06 APE9-dihe-in -128.9, 119.34 APE8-dihe-in -79.6, 67.11 APE8-rot-na 30.51 APE67-dihe-in -77.81, 0.08 -48.0, -39.27 APE12-dist-na 13.558 APE11-dist-na 10.078 APE10-dist-na 8.259 APE9-dist-in 7.021 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E PTR769 PTR769 XRAY 2.606 0.191 0.237 A 334 302 7 0 0 0 [[481, 759]] 1.0 5eg3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.3e-101 344.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN AF-P21802-K1A P21802 473 767 821.0 No_ligand No_ligand Active DFGin 6.601 13.828 BLAminus -133.68, -169.57 52.57, 69.39 -87.88, 10.6 290.58, 96.54 -58.9, -30.33 in-in in 7.455 Saltbr-in 2.604 HRD-in -70.96, -43.8 66.39, -18.89 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.66, 121.21 APE9-dihe-in -133.82, 152.44 APE8-dihe-in -79.15, 83.67 APE8-rot-na 36.61 APE67-dihe-in -67.33, -12.18 -47.11, -39.95 APE12-dist-na 14.429 APE11-dist-na 9.835 APE10-dist-na 10.022 APE9-dist-in 6.266 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[481, 759]] 1.0 AF-P21802-K1 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN AF-P21802-K3A P21802 473 767 821.0 No_ligand No_ligand Active DFGin 6.209 13.501 BLAminus -141.01, -176.93 60.04, 66.75 -80.69, 12.07 290.46, 96.57 -59.23, -29.09 in-in in 7.925 Saltbr-in 2.657 HRD-in -80.72, -44.06 61.54, -5.0 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.89, 136.41 APE9-dihe-in -134.04, 129.71 APE8-dihe-in -82.57, 64.16 APE8-rot-na 35.64 APE67-dihe-in -69.31, -10.22 -46.98, -44.55 APE12-dist-na 13.459 APE11-dist-na 9.774 APE10-dist-na 8.159 APE9-dist-in 6.654 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[481, 759]] 1.0 AF-P21802-K3 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PWLA P21802 467 764 821.0 ACP:300 ATPlike Inactive DFGin 6.451 14.178 BLAminus -131.61, -167.38 56.51, 73.64 -92.98, 26.06 293.6, 74.93 -63.45, -20.7 in-in in 7.586 Saltbr-in 2.856 HRD-in -77.4, -49.09 71.28, -7.85 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.03, 20.75 APE9-dihe-in -94.74, 135.38 APE8-dihe-in -58.69, 123.68 APE8-rot-na 326.81 APE67-dihe-in -69.99, -5.92 -52.74, -45.54 APE12-dist-na 10.002 APE11-dist-na 10.678 APE10-dist-na 7.432 APE9-dist-in 4.749 C491A,N549H None None XRAY 2.4 0.21 0.238 A 324 284 14 0 0 0 [[481, 759]] 1.0 2pwl Homo sapiens TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PWLB P21802 468 765 821.0 ACP:300 ATPlike Inactive DFGin 6.439 14.28 BLAminus -131.94, -168.62 54.17, 75.02 -93.02, 25.01 292.99, 76.23 -61.28, -25.59 in-in in 7.692 Saltbr-in 3.07 HRD-in -69.87, -47.96 69.48, -8.93 in-in-out SNCiio in-out ActLoopNT-in 2.916 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.23, 16.85 APE9-dihe-in -95.43, 136.0 APE8-dihe-in -55.13, 121.27 APE8-rot-na 324.13 APE67-dihe-in -66.61, -7.86 -55.94, -44.16 APE12-dist-na 10.089 APE11-dist-na 10.854 APE10-dist-na 7.485 APE9-dist-in 4.912 C491A,N549H None None XRAY 2.4 0.21 0.238 B 324 286 12 0 0 0 [[481, 759]] 1.0 2pwl Homo sapiens TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UGLA P21802 468 764 821.0 ANP:802 ATPlike Inactive DFGin 6.732 14.464 BLAminus -137.83, -175.53 60.75, 66.42 -85.03, 17.04 287.79, 92.86 -66.15, -23.38 in-in in 7.669 Saltbr-in 2.761 HRD-in -76.2, -48.26 75.23, -6.81 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.99, 26.82 APE9-dihe-in -107.7, 135.68 APE8-dihe-in -52.5, 118.32 APE8-rot-na 330.79 APE67-dihe-in -70.92, -8.04 -59.23, -38.34 APE12-dist-na 14.887 APE11-dist-na 10.816 APE10-dist-na 7.642 APE9-dist-in 5.103 D650V None None XRAY 1.861 0.221 0.258 A 324 285 12 0 0 0 [[481, 759]] 1.0 5ugl Homo sapiens TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UGLB P21802 467 764 821.0 ANP:802 ATPlike Inactive DFGin 6.738 14.48 BLAminus -137.57, -172.18 55.78, 69.64 -87.75, 15.81 286.63, 92.96 -64.54, -22.36 in-in in 7.653 Saltbr-in 2.718 HRD-in -74.83, -48.38 75.49, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.07, 25.73 APE9-dihe-in -107.84, 135.51 APE8-dihe-in -51.06, 118.2 APE8-rot-na 329.13 APE67-dihe-in -71.28, -8.69 -57.7, -39.45 APE12-dist-na 999.0 APE11-dist-na 10.831 APE10-dist-na 7.669 APE9-dist-in 5.084 D650V None None XRAY 1.861 0.221 0.258 B 324 271 27 0 0 11 [[481, 759]] 1.0 5ugl Homo sapiens TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J96B P21802 462 766 821.0 ACP:803 ATPlike Inactive DFGin 6.422 14.069 BLAminus -135.07, -171.17 49.96, 77.75 -93.13, 20.28 283.65, 85.2 -66.67, -18.8 in-out in 7.205 Saltbr-out 3.691 HRD-in -86.85, -47.88 76.0, -13.66 out-in-out SNCoio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 28.85 APE9-dihe-in -99.38, 128.67 APE8-dihe-in -54.56, 125.51 APE8-rot-na 329.88 APE67-dihe-in -70.35, -5.29 -58.48, -39.96 APE12-dist-na 14.724 APE11-dist-na 10.154 APE10-dist-na 7.507 APE9-dist-in 4.93 C491A,K659M None None XRAY 2.297 0.178 0.219 B 324 305 0 0 0 0 [[481, 759]] 1.0 4j96 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J98B P21802 461 764 821.0 ACP:804 ATPlike Inactive DFGin 6.55 14.042 BLAminus -130.09, -172.54 52.51, 78.98 -94.32, 21.96 285.07, 86.18 -63.61, -22.45 in-in in 7.113 Saltbr-in 3.017 HRD-in -86.21, -48.16 74.7, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.22, 26.63 APE9-dihe-in -99.48, 124.84 APE8-dihe-in -50.97, 125.51 APE8-rot-na 328.99 APE67-dihe-in -68.16, -7.57 -60.28, -41.11 APE12-dist-na 15.096 APE11-dist-na 10.418 APE10-dist-na 7.58 APE9-dist-in 4.827 C491A,K659Q None None XRAY 2.307 0.19 0.234 B 324 304 0 0 0 0 [[481, 759]] 1.0 4j98 Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J99A P21802 466 764 821.0 ACP:802 ATPlike Inactive DFGin 6.715 14.14 BLAminus -130.96, -174.69 58.83, 77.45 -92.73, 19.29 291.78, 87.39 -60.03, -34.11 in-in in 7.61 Saltbr-in 2.845 HRD-in -78.19, -48.52 73.01, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.36, 29.03 APE9-dihe-in -109.75, 138.54 APE8-dihe-in -57.3, 116.33 APE8-rot-na 330.48 APE67-dihe-in -70.7, -10.42 -57.47, -40.52 APE12-dist-na 15.04 APE11-dist-na 11.232 APE10-dist-na 7.972 APE9-dist-in 5.13 C491A,K659T None None XRAY 1.847 0.206 0.24 A 324 280 19 0 0 4 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J99B P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.666 14.188 BLAminus -133.21, -176.0 58.56, 76.97 -94.04, 15.78 292.83, 99.53 -58.91, -32.83 in-in in 7.584 Saltbr-in 2.616 HRD-in -76.65, -48.86 73.31, -6.92 in-in-out SNCiio in-out ActLoopNT-in 2.9 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.89, 30.62 APE9-dihe-in -108.84, 137.25 APE8-dihe-in -57.12, 118.19 APE8-rot-na 330.19 APE67-dihe-in -70.1, -10.12 -57.01, -39.76 APE12-dist-na 14.148 APE11-dist-na 11.074 APE10-dist-na 8.007 APE9-dist-in 5.18 C491A,K659T None None XRAY 1.847 0.206 0.24 B 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J99C P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.835 14.168 BLAminus -131.87, -175.54 59.17, 75.71 -91.42, 19.92 291.67, 85.71 -59.92, -32.59 in-in in 7.628 Saltbr-in 2.913 HRD-in -76.88, -47.72 74.23, -7.36 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.66, 30.6 APE9-dihe-in -110.19, 138.06 APE8-dihe-in -55.44, 118.46 APE8-rot-na 330.51 APE67-dihe-in -70.73, -10.29 -57.12, -38.65 APE12-dist-na 14.121 APE11-dist-na 10.954 APE10-dist-na 8.05 APE9-dist-in 5.362 C491A,K659T None None XRAY 1.847 0.206 0.24 C 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J99D P21802 465 764 821.0 ACP:802 ATPlike Inactive DFGin 6.593 14.159 BLAminus -133.66, -174.57 58.72, 78.56 -92.61, 20.44 290.96, 82.99 -59.4, -33.38 in-in in 7.631 Saltbr-in 2.639 HRD-in -78.38, -50.11 73.68, -6.22 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.76, 31.03 APE9-dihe-in -108.34, 137.61 APE8-dihe-in -55.35, 118.06 APE8-rot-na 330.85 APE67-dihe-in -71.9, -11.56 -55.67, -38.95 APE12-dist-na 999.0 APE11-dist-na 11.135 APE10-dist-na 7.859 APE9-dist-in 4.992 C491A,K659T None None XRAY 1.847 0.206 0.24 D 324 281 19 0 0 3 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PVYA P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.75 14.274 BLAminus -142.14, -176.01 63.9, 72.69 -96.2, 30.01 293.76, 86.07 -65.9, -30.73 in-in in 7.547 Saltbr-in 2.852 HRD-in -84.99, -48.7 74.29, -16.98 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.15, 32.71 APE9-dihe-in -103.67, 126.67 APE8-dihe-in -51.63, 122.63 APE8-rot-na 323.69 APE67-dihe-in -64.04, -12.74 -56.98, -40.88 APE12-dist-na 14.814 APE11-dist-na 10.095 APE10-dist-na 7.537 APE9-dist-in 4.955 C491A,K659N None None XRAY 2.2 0.236 0.276 A 324 288 10 0 0 0 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PVYB P21802 462 764 821.0 ACP:8002 ATPlike Inactive DFGin 6.635 14.065 BLAminus -144.27, -177.95 57.14, 77.78 -93.97, 24.89 293.34, 84.21 -55.49, -34.1 in-in in 7.316 Saltbr-in 2.847 HRD-in -81.21, -48.71 71.97, -12.52 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.68, 30.22 APE9-dihe-in -107.46, 135.49 APE8-dihe-in -57.98, 120.91 APE8-rot-na 329.38 APE67-dihe-in -64.69, -5.42 -51.47, -46.8 APE12-dist-na 999.0 APE11-dist-na 10.694 APE10-dist-na 7.435 APE9-dist-in 5.066 C491A,K659N None None XRAY 2.2 0.236 0.276 B 324 286 17 0 0 6 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PVYC P21802 462 764 821.0 ACP:802 ATPlike Inactive DFGin 6.693 14.018 BLAminus -131.41, -174.32 49.42, 82.58 -94.81, 27.78 293.52, 79.4 -60.72, -24.91 in-in in 7.229 Saltbr-in 3.577 HRD-in -81.5, -47.6 72.07, -14.53 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.89, 24.55 APE9-dihe-in -101.87, 134.03 APE8-dihe-in -55.3, 120.87 APE8-rot-na 330.19 APE67-dihe-in -64.04, -6.89 -51.83, -46.76 APE12-dist-na 14.316 APE11-dist-na 10.323 APE10-dist-na 7.438 APE9-dist-in 5.069 C491A,K659N None None XRAY 2.2 0.236 0.276 C 324 285 18 0 0 5 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PVYD P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.944 14.261 BLAminus -139.76, -174.3 61.15, 74.17 -97.41, 31.68 293.81, 79.18 -66.75, -30.92 in-in in 7.298 Saltbr-in 3.036 HRD-in -85.65, -49.02 75.46, -18.01 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.37, 33.11 APE9-dihe-in -102.8, 126.29 APE8-dihe-in -51.84, 123.89 APE8-rot-na 324.49 APE67-dihe-in -63.66, -13.12 -61.69, -37.66 APE12-dist-na 14.828 APE11-dist-na 10.092 APE10-dist-na 7.57 APE9-dist-in 4.968 C491A,K659N None None XRAY 2.2 0.236 0.276 D 324 283 15 0 0 0 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J95A P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.691 14.058 BLAminus -131.56, -174.19 63.25, 76.63 -98.25, 22.24 292.31, 85.68 -64.6, -23.3 in-in in 7.752 Saltbr-in 2.811 HRD-in -79.93, -52.54 74.87, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.79, 21.67 APE9-dihe-in -99.53, 131.21 APE8-dihe-in -54.93, 120.24 APE8-rot-na 331.68 APE67-dihe-in -73.86, -8.05 -61.39, -39.09 APE12-dist-na 14.773 APE11-dist-na 10.953 APE10-dist-na 7.48 APE9-dist-in 4.867 C491A,K659N None None XRAY 2.377 0.214 0.255 A 324 279 19 0 0 4 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J95B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.677 14.378 BLAminus -131.79, -176.38 62.78, 77.42 -96.59, 21.6 290.19, 86.46 -65.99, -23.31 in-in in 7.797 Saltbr-in 2.903 HRD-in -80.06, -52.15 74.05, -5.91 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.95, 20.73 APE9-dihe-in -101.19, 131.88 APE8-dihe-in -53.9, 121.25 APE8-rot-na 331.03 APE67-dihe-in -73.96, -6.54 -59.67, -39.95 APE12-dist-na 14.977 APE11-dist-na 11.021 APE10-dist-na 7.709 APE9-dist-in 4.856 C491A,K659N None None XRAY 2.377 0.214 0.255 B 324 282 15 0 0 0 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J95C P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.762 14.317 BLAminus -132.19, -176.54 63.57, 76.14 -98.34, 23.39 290.03, 85.39 -65.87, -22.89 in-in in 7.736 Saltbr-in 2.825 HRD-in -79.64, -52.73 75.27, -7.0 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.5, 23.85 APE9-dihe-in -97.28, 128.27 APE8-dihe-in -54.92, 121.79 APE8-rot-na 330.61 APE67-dihe-in -73.19, -7.42 -60.17, -39.19 APE12-dist-na 14.732 APE11-dist-na 10.365 APE10-dist-na 7.413 APE9-dist-in 4.906 C491A,K659N None None XRAY 2.377 0.214 0.255 C 324 281 16 0 0 0 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J95D P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.601 14.074 BLAminus -131.84, -175.28 62.91, 77.06 -96.79, 22.82 289.52, 85.1 -64.56, -22.95 in-in in 7.641 Saltbr-in 2.747 HRD-in -80.37, -53.3 74.73, -6.2 in-in-out SNCiio in-out ActLoopNT-in 3.033 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.03, 23.13 APE9-dihe-in -98.93, 130.46 APE8-dihe-in -52.66, 122.62 APE8-rot-na 330.72 APE67-dihe-in -75.07, -8.74 -59.5, -40.3 APE12-dist-na 999.0 APE11-dist-na 10.804 APE10-dist-na 7.616 APE9-dist-in 4.803 C491A,K659N None None XRAY 2.377 0.214 0.255 D 324 271 27 0 0 11 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PZ5A P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.27 14.129 BLAminus -134.55, -165.25 46.14, 76.71 -87.82, 24.61 288.3, 73.06 -57.77, -17.99 in-in in 7.376 Saltbr-in 2.72 HRD-in -71.49, -53.18 74.61, -7.33 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.92, 23.05 APE9-dihe-in -100.29, 130.1 APE8-dihe-in -50.24, 116.35 APE8-rot-na 324.43 APE67-dihe-in -70.43, -5.4 -48.06, -44.87 APE12-dist-na 10.162 APE11-dist-na 10.892 APE10-dist-na 7.555 APE9-dist-in 4.83 C491A,N549T None None XRAY 2.4 0.214 0.254 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PZ5B P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.42 14.223 BLAminus -139.02, -170.4 49.42, 74.35 -88.07, 29.83 289.06, 77.09 -65.84, -12.67 in-in in 7.304 Saltbr-in 2.773 HRD-in -68.79, -48.45 71.17, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.66, 23.86 APE9-dihe-in -102.44, 130.7 APE8-dihe-in -54.21, 119.21 APE8-rot-na 323.97 APE67-dihe-in -67.2, -7.87 -53.61, -43.12 APE12-dist-na 10.046 APE11-dist-na 10.812 APE10-dist-na 7.393 APE9-dist-in 4.981 C491A,N549T None None XRAY 2.4 0.214 0.254 B 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J97A P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.55 14.123 BLAminus -139.14, -173.61 59.78, 71.54 -95.85, 23.3 290.64, 88.77 -67.56, -16.73 in-in in 7.316 Saltbr-in 3.004 HRD-in -83.97, -47.07 72.51, -7.44 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.39, 21.13 APE9-dihe-in -97.79, 130.15 APE8-dihe-in -58.11, 126.83 APE8-rot-na 332.95 APE67-dihe-in -66.85, -7.34 -61.56, -42.87 APE12-dist-na 15.336 APE11-dist-na 10.692 APE10-dist-na 7.744 APE9-dist-in 4.882 C491A,K659E None None XRAY 2.548 0.202 0.257 A 324 282 15 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J97B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.619 14.161 BLAminus -137.2, -170.97 56.98, 77.11 -102.2, 28.96 291.71, 89.32 -70.08, -17.2 in-in in 7.432 Saltbr-in 2.683 HRD-in -92.02, -43.47 71.93, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.22, 28.28 APE9-dihe-in -102.89, 130.04 APE8-dihe-in -52.94, 125.61 APE8-rot-na 331.88 APE67-dihe-in -68.38, -8.99 -59.09, -43.64 APE12-dist-na 15.333 APE11-dist-na 10.637 APE10-dist-na 7.778 APE9-dist-in 4.888 C491A,K659E None None XRAY 2.548 0.202 0.257 B 324 283 14 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J97C P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.645 13.946 BLAminus -135.48, -176.12 59.98, 78.76 -103.0, 29.61 294.18, 85.28 -73.23, -9.75 in-in in 7.37 Saltbr-in 2.772 HRD-in -84.13, -44.14 69.93, -6.04 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 19.13 APE9-dihe-in -91.95, 123.86 APE8-dihe-in -53.96, 120.55 APE8-rot-na 330.23 APE67-dihe-in -67.12, -15.11 -56.46, -44.57 APE12-dist-na 15.284 APE11-dist-na 10.828 APE10-dist-na 7.639 APE9-dist-in 4.85 C491A,K659E None None XRAY 2.548 0.202 0.257 C 324 283 15 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J97D P21802 466 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6 13.952 BLAminus -140.55, -174.15 59.58, 71.6 -94.76, 28.97 293.72, 82.5 -71.76, -12.96 in-in in 7.326 Saltbr-in 3.288 HRD-in -86.64, -45.82 71.0, -4.65 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.43, 15.17 APE9-dihe-in -92.91, 126.7 APE8-dihe-in -55.77, 123.75 APE8-rot-na 332.18 APE67-dihe-in -67.8, -5.5 -58.98, -44.55 APE12-dist-na 15.175 APE11-dist-na 10.81 APE10-dist-na 7.653 APE9-dist-in 4.774 C491A,K659E None None XRAY 2.548 0.202 0.257 D 324 285 14 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PZPA P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.348 14.188 BLAminus -137.17, -165.33 46.36, 75.76 -87.8, 26.94 288.76, 75.56 -66.87, -3.87 in-in in 7.412 Saltbr-in 2.646 HRD-in -73.32, -51.09 75.46, -8.12 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.47, 19.17 APE9-dihe-in -100.03, 131.76 APE8-dihe-in -52.44, 119.43 APE8-rot-na 323.26 APE67-dihe-in -75.98, -2.12 -50.98, -36.8 APE12-dist-na 10.034 APE11-dist-na 10.845 APE10-dist-na 7.456 APE9-dist-in 4.835 C491A,K526E None None XRAY 2.4 0.214 0.251 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pzp Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PZPB P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.413 14.352 BLAminus -140.32, -168.12 49.24, 73.06 -87.89, 30.48 288.51, 77.76 -65.07, -14.98 in-in in 7.479 Saltbr-in 2.588 HRD-in -76.07, -43.76 66.74, -12.17 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.0, 26.29 APE9-dihe-in -103.21, 127.34 APE8-dihe-in -50.89, 117.65 APE8-rot-na 324.07 APE67-dihe-in -70.61, -2.41 -52.07, -42.82 APE12-dist-na 10.141 APE11-dist-na 10.802 APE10-dist-na 7.451 APE9-dist-in 4.964 C491A,K526E None None XRAY 2.4 0.214 0.251 B 324 282 17 0 0 0 [[481, 759]] 1.0 2pzp Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PZRA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.528 14.087 BLAminus -124.48, -173.68 60.99, 80.27 -100.69, 20.88 290.45, 81.11 -57.12, -25.75 in-in in 7.418 Saltbr-in 2.648 HRD-in -69.22, -43.88 65.36, -10.35 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.95, 17.65 APE9-dihe-in -96.03, 130.55 APE8-dihe-in -55.73, 111.71 APE8-rot-na 326.73 APE67-dihe-in -57.11, -22.38 -39.78, -52.21 APE12-dist-na 9.973 APE11-dist-na 10.692 APE10-dist-na 7.386 APE9-dist-in 4.734 C491A,K641R None None XRAY 3.0 0.201 0.268 A 324 280 18 0 0 0 [[481, 759]] 1.0 2pzr Homo sapiens TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PZRB P21802 467 766 821.0 ACP:803 ATPlike Inactive DFGin 6.446 14.135 BLAminus -124.12, -169.42 57.57, 72.92 -93.39, 13.68 295.44, 82.57 -53.73, -21.74 in-in in 7.634 Saltbr-in 2.706 HRD-in -69.55, -51.19 76.09, -22.69 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.28, 13.02 APE9-dihe-in -94.85, 132.36 APE8-dihe-in -55.27, 118.14 APE8-rot-na 326.76 APE67-dihe-in -72.22, 2.52 -57.29, -38.32 APE12-dist-na 9.949 APE11-dist-na 10.979 APE10-dist-na 7.519 APE9-dist-in 5.016 C491A,K641R None None XRAY 3.0 0.201 0.268 B 324 282 18 0 0 0 [[481, 759]] 1.0 2pzr Homo sapiens TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UHNA P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.517 14.094 BLAminus -136.8, -167.33 56.16, 78.56 -101.45, 21.6 294.96, 102.9 -64.06, -30.14 in-in in 7.824 Saltbr-in 2.523 HRD-in -81.24, -42.19 65.24, 0.64 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.72, 22.85 APE9-dihe-in -103.03, 139.99 APE8-dihe-in -59.98, 123.73 APE8-rot-na 335.04 APE67-dihe-in -66.52, -14.98 -63.65, -42.1 APE12-dist-na 14.855 APE11-dist-na 10.903 APE10-dist-na 7.587 APE9-dist-in 4.884 N549H,E565A None None XRAY 2.909 0.26 0.311 A 324 282 14 0 0 0 [[481, 759]] 1.0 5uhn Homo sapiens TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UHNB P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.513 14.023 BLAminus -136.33, -166.28 57.28, 77.94 -101.83, 20.57 295.09, 103.12 -64.81, -29.84 in-in in 7.663 Saltbr-in 2.464 HRD-in -80.51, -42.21 65.56, -0.07 in-in-out SNCiio in-out ActLoopNT-in 3.183 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -129.68, 22.67 APE9-dihe-in -103.05, 139.67 APE8-dihe-in -60.5, 125.01 APE8-rot-na 334.93 APE67-dihe-in -66.52, -14.36 -63.18, -41.76 APE12-dist-na 999.0 APE11-dist-na 10.814 APE10-dist-na 7.591 APE9-dist-in 4.817 N549H,E565A None None XRAY 2.909 0.26 0.311 B 324 269 27 0 0 11 [[481, 759]] 1.0 5uhn Homo sapiens TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UGXA P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.657 14.049 BLAminus -131.13, -166.11 46.79, 87.05 -100.0, 21.89 288.47, 85.57 -64.83, -24.6 in-in in 7.609 Saltbr-in 2.992 HRD-in -78.16, -51.21 73.9, -1.28 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.33, 9.75 APE9-dihe-in -97.42, 138.88 APE8-dihe-in -59.74, 121.4 APE8-rot-na 334.26 APE67-dihe-in -70.7, -5.46 -65.5, -39.78 APE12-dist-na 15.029 APE11-dist-na 11.177 APE10-dist-na 7.458 APE9-dist-in 4.804 C491A,E565A None None XRAY 2.349 0.22 0.275 A 324 297 0 0 0 0 [[481, 759]] 1.0 5ugx Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UGXB P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.711 13.923 BLAminus -132.31, -170.71 52.3, 81.71 -96.0, 22.25 292.25, 87.7 -65.69, -25.27 in-in in 7.393 Saltbr-in 3.154 HRD-in -75.61, -53.17 73.28, -1.77 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.49, 16.52 APE9-dihe-in -100.17, 138.41 APE8-dihe-in -61.9, 122.99 APE8-rot-na 336.36 APE67-dihe-in -71.64, -5.56 -62.65, -38.67 APE12-dist-na 10.081 APE11-dist-na 10.766 APE10-dist-na 7.282 APE9-dist-in 4.828 C491A,E565A None None XRAY 2.349 0.22 0.275 B 324 282 15 0 0 10 [[481, 759]] 1.0 5ugx Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UI0B P21802 462 765 821.0 ACP:802 ATPlike Inactive DFGin 6.542 14.213 BLAminus -136.98, -171.82 50.02, 76.91 -91.39, 21.0 284.06, 84.3 -70.34, -15.26 in-in in 7.243 Saltbr-in 2.959 HRD-in -80.63, -49.98 74.74, -10.37 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.5, 32.27 APE9-dihe-in -102.72, 128.27 APE8-dihe-in -51.42, 123.86 APE8-rot-na 328.96 APE67-dihe-in -69.39, -7.95 -60.08, -38.03 APE12-dist-na 14.784 APE11-dist-na 10.166 APE10-dist-na 7.606 APE9-dist-in 4.855 C491A,E565A None None XRAY 2.05 0.183 0.207 B 324 304 0 0 0 0 [[481, 759]] 1.0 5ui0 Homo sapiens TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2Q0BA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.538 14.238 BLAminus -137.67, -164.26 54.31, 72.63 -95.24, 25.26 285.39, 75.18 -61.23, -29.58 in-in in 7.243 Saltbr-in 2.723 HRD-in -79.58, -49.69 74.6, -12.22 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.18, 17.09 APE9-dihe-in -97.34, 129.87 APE8-dihe-in -55.33, 120.72 APE8-rot-na 329.23 APE67-dihe-in -73.97, -8.32 -57.44, -31.43 APE12-dist-na 9.977 APE11-dist-na 10.659 APE10-dist-na 7.369 APE9-dist-in 4.751 C491A,E565A None None XRAY 2.9 0.202 0.252 A 324 280 18 0 0 0 [[481, 759]] 1.0 2q0b Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2Q0BB P21802 468 766 821.0 ACP:803 ATPlike Inactive DFGin 6.564 14.08 BLAminus -133.38, -173.77 65.46, 65.65 -91.7, 18.1 296.71, 72.83 -55.14, -29.53 in-in in 7.517 Saltbr-in 2.736 HRD-in -79.58, -50.53 70.04, -4.81 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.91, 21.68 APE9-dihe-in -99.61, 129.39 APE8-dihe-in -57.39, 112.59 APE8-rot-na 331.0 APE67-dihe-in -63.49, -9.98 -54.36, -36.94 APE12-dist-na 10.247 APE11-dist-na 10.839 APE10-dist-na 7.492 APE9-dist-in 4.906 C491A,E565A None None XRAY 2.9 0.202 0.252 B 324 282 17 0 0 0 [[481, 759]] 1.0 2q0b Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PY3A P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.395 14.125 BLAminus -132.09, -167.28 46.92, 77.9 -89.52, 28.18 287.97, 74.42 -64.92, -12.84 in-in in 7.278 Saltbr-in 2.643 HRD-in -69.15, -50.28 73.37, -7.92 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.57, 22.43 APE9-dihe-in -99.04, 131.25 APE8-dihe-in -52.37, 122.48 APE8-rot-na 325.05 APE67-dihe-in -72.14, -6.33 -51.92, -40.9 APE12-dist-na 9.95 APE11-dist-na 10.671 APE10-dist-na 7.386 APE9-dist-in 4.744 C491A,E565G None None XRAY 2.3 0.217 0.252 A 324 282 17 0 0 0 [[481, 759]] 1.0 2py3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PY3B P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.515 14.301 BLAminus -135.62, -170.09 51.9, 73.7 -89.2, 28.31 287.78, 75.56 -66.05, -13.03 in-in in 7.425 Saltbr-in 2.704 HRD-in -75.46, -47.46 71.33, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.61, 23.33 APE9-dihe-in -100.25, 127.63 APE8-dihe-in -52.55, 116.2 APE8-rot-na 325.69 APE67-dihe-in -68.53, -13.02 -47.88, -42.42 APE12-dist-na 10.066 APE11-dist-na 10.788 APE10-dist-na 7.419 APE9-dist-in 4.931 C491A,E565G None None XRAY 2.3 0.217 0.252 B 324 284 15 0 0 0 [[481, 759]] 1.0 2py3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6V6QA P21802 466 765 821.0 ACP:901 ATPlike Inactive DFGin 6.894 13.908 BLAminus -137.26, -178.98 59.51, 71.9 -86.77, 13.5 292.04, 83.56 -59.04, -31.29 in-in in 7.246 Saltbr-in 3.289 HRD-in -72.64, -45.97 77.04, -16.81 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.45, 33.95 APE9-dihe-in -111.95, 129.79 APE8-dihe-in -53.65, 121.81 APE8-rot-na 327.05 APE67-dihe-in -70.56, -11.31 -58.83, -38.12 APE12-dist-na 14.264 APE11-dist-na 10.49 APE10-dist-na 7.77 APE9-dist-in 5.206 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 A 411 286 14 0 0 0 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6V6QB P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.809 14.125 BLAminus -136.61, -177.61 60.52, 69.31 -88.63, 15.47 290.7, 96.84 -63.12, -28.34 in-in in 7.343 Saltbr-in 3.295 HRD-in -73.07, -46.4 74.87, -14.44 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.84, 37.71 APE9-dihe-in -109.58, 130.31 APE8-dihe-in -50.87, 122.1 APE8-rot-na 324.14 APE67-dihe-in -69.97, -12.27 -61.49, -37.1 APE12-dist-na 14.135 APE11-dist-na 10.587 APE10-dist-na 8.065 APE9-dist-in 5.152 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 B 411 291 9 0 0 0 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6V6QD P21802 467 765 821.0 ACP:901 ATPlike Inactive DFGin 6.936 13.989 BLAminus -136.56, -179.05 59.21, 72.83 -88.1, 16.16 292.51, 97.85 -58.15, -33.51 in-in in 7.38 Saltbr-in 3.334 HRD-in -71.81, -47.08 75.08, -13.84 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.25, 35.34 APE9-dihe-in -111.85, 128.58 APE8-dihe-in -53.13, 121.4 APE8-rot-na 327.69 APE67-dihe-in -69.26, -12.5 -60.26, -36.04 APE12-dist-na 999.0 APE11-dist-na 10.14 APE10-dist-na 7.433 APE9-dist-in 5.112 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 D 411 276 23 0 0 9 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8SWEA P21802 468 765 821.0 GSH:802,WXQ:803 Allosteric,Type1 Inactive DFGin 6.584 14.421 BLAminus -150.2, -171.84 53.84, 62.99 -84.08, 24.59 289.03, 91.27 -65.33, -29.69 in-in in 7.667 Saltbr-in 3.478 HRD-in -78.34, -48.7 72.49, -5.74 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.6, 22.79 APE9-dihe-in -98.31, 134.63 APE8-dihe-in -56.2, 130.73 APE8-rot-na 335.99 APE67-dihe-in -78.04, -7.77 -69.42, -32.87 APE12-dist-na 10.083 APE11-dist-na 10.72 APE10-dist-na 7.381 APE9-dist-in 4.861 None None None XRAY 2.24 0.212 0.25 A 316 284 14 0 0 0 [[481, 759]] 1.0 8swe Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J96A P21802 461 766 821.0 No_ligand No_ligand Inactive DFGin 6.898 14.243 BLAminus -129.08, -173.93 55.13, 75.05 -93.92, 17.08 285.11, 85.16 -64.81, -20.47 in-in in 7.291 Saltbr-in 3.106 HRD-in -86.2, -46.65 77.15, -15.27 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.58, 28.84 APE9-dihe-in -101.23, 126.83 APE8-dihe-in -54.36, 124.63 APE8-rot-na 330.34 APE67-dihe-in -70.0, -5.4 -59.65, -38.1 APE12-dist-na 14.933 APE11-dist-na 10.292 APE10-dist-na 7.443 APE9-dist-in 4.913 C491A,K659M None None XRAY 2.297 0.178 0.219 A 324 302 4 0 0 0 [[481, 759]] 1.0 4j96 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 4J98A P21802 461 764 821.0 No_ligand No_ligand Inactive DFGin 6.895 14.189 BLAminus -127.05, -173.93 55.52, 75.94 -94.55, 21.07 285.33, 84.3 -62.1, -22.56 in-in in 7.272 Saltbr-in 2.708 HRD-in -84.97, -48.15 77.1, -13.76 in-in-out SNCiio in-out ActLoopNT-in 2.892 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.08, 26.13 APE9-dihe-in -100.11, 126.32 APE8-dihe-in -52.05, 125.82 APE8-rot-na 328.58 APE67-dihe-in -66.67, -7.8 -60.08, -40.94 APE12-dist-na 15.203 APE11-dist-na 10.5 APE10-dist-na 7.501 APE9-dist-in 5.005 C491A,K659Q None None XRAY 2.307 0.19 0.234 A 324 304 0 0 0 0 [[481, 759]] 1.0 4j98 Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 1GJOA P21802 467 764 821.0 No_ligand No_ligand Inactive DFGin 6.411 13.804 BLAminus -126.56, -173.35 57.91, 77.01 -93.75, 23.86 297.55, 90.05 -64.9, -30.61 in-in in 7.438 Saltbr-in 2.712 HRD-in -71.21, -44.77 68.97, -0.99 in-in-out SNCiio in-out ActLoopNT-in 2.896 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.53, 8.59 APE9-dihe-in -95.09, 140.9 APE8-dihe-in -65.99, 123.98 APE8-rot-na 24.92 APE67-dihe-in -67.17, -8.94 -56.08, -37.69 APE12-dist-na 9.89 APE11-dist-na 11.084 APE10-dist-na 7.484 APE9-dist-in 4.718 None None None XRAY 2.4 0.214 0.256 A 316 280 18 0 0 0 [[481, 759]] 1.0 1gjo Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 5UI0A P21802 461 766 821.0 No_ligand No_ligand Inactive DFGin 6.705 14.36 BLAminus -135.62, -171.25 53.76, 73.69 -92.94, 20.04 285.17, 82.93 -70.08, -15.73 in-in in 7.271 Saltbr-in 2.866 HRD-in -79.02, -49.38 75.99, -10.91 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.85, 29.9 APE9-dihe-in -103.97, 128.06 APE8-dihe-in -51.81, 123.04 APE8-rot-na 328.88 APE67-dihe-in -69.55, -8.5 -59.7, -37.83 APE12-dist-na 14.893 APE11-dist-na 10.291 APE10-dist-na 7.544 APE9-dist-in 4.949 C491A,E565A None None XRAY 2.05 0.183 0.207 A 324 301 5 0 0 0 [[481, 759]] 1.0 5ui0 Homo sapiens TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PSQA P21802 468 765 821.0 No_ligand No_ligand Inactive DFGin 6.875 13.721 BLAminus -128.93, -172.72 52.18, 79.93 -92.08, 23.28 298.98, 73.8 -58.43, -25.99 in-in in 7.48 Saltbr-in 3.2 HRD-in -73.69, -49.43 74.12, -12.4 in-in-out SNCiio in-out ActLoopNT-in 2.946 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.29, 16.98 APE9-dihe-in -98.81, 130.21 APE8-dihe-in -53.9, 115.54 APE8-rot-na 323.02 APE67-dihe-in -67.54, -7.82 -55.22, -37.78 APE12-dist-na 10.124 APE11-dist-na 10.695 APE10-dist-na 7.21 APE9-dist-in 5.042 None None None XRAY 2.4 0.211 0.258 A 370 287 11 0 0 0 [[481, 759]] 1.0 2psq Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 2PSQB P21802 467 766 821.0 No_ligand No_ligand Inactive DFGin 6.661 13.838 BLAminus -134.84, -175.34 56.99, 78.24 -93.68, 24.63 295.92, 77.95 -61.79, -34.13 in-in in 7.411 Saltbr-in 2.689 HRD-in -74.4, -46.06 70.25, -13.53 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.1, 12.51 APE9-dihe-in -92.24, 130.01 APE8-dihe-in -52.44, 120.68 APE8-rot-na 324.14 APE67-dihe-in -73.23, -4.23 -55.2, -38.33 APE12-dist-na 9.949 APE11-dist-na 10.675 APE10-dist-na 7.206 APE9-dist-in 5.022 None None None XRAY 2.4 0.211 0.258 B 370 286 14 0 0 0 [[481, 759]] 1.0 2psq Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 3B2TA P21802 464 768 821.0 M33:1996 Type1 Inactive DFGin 6.43 14.187 BLAminus -134.3, -170.91 55.38, 73.11 -95.45, 19.5 296.12, 88.0 -64.8, -24.9 in-out in 7.374 Saltbr-out 3.738 HRD-in -75.34, -50.16 72.8, -10.74 out-in-out SNCoio in-out ActLoopNT-in 2.899 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.58, 14.29 APE9-dihe-in -98.64, 149.61 APE8-dihe-in -68.58, 112.73 APE8-rot-na 30.55 APE67-dihe-in -69.45, -7.24 -48.9, -42.7 APE12-dist-na 10.036 APE11-dist-na 10.988 APE10-dist-na 7.335 APE9-dist-in 4.705 A628T,E767Q None None XRAY 1.8 0.201 0.233 A 311 288 17 0 0 0 [[481, 759]] 1.0 3b2t Homo sapiens TYR_FGFR2_HUMAN TYR 1.4e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 3B2TB P21802 458 764 821.0 M33:1996 Type1 Inactive DFGin 6.509 14.155 BLAminus -136.01, -172.09 58.4, 72.93 -97.2, 21.29 297.11, 82.42 -63.1, -25.65 in-in in 7.376 Saltbr-in 2.752 HRD-in -77.18, -48.4 71.64, -8.98 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.99, 11.19 APE9-dihe-in -95.96, 149.11 APE8-dihe-in -68.88, 112.58 APE8-rot-na 32.44 APE67-dihe-in -68.01, -6.57 -48.48, -44.81 APE12-dist-na 9.998 APE11-dist-na 10.941 APE10-dist-na 7.274 APE9-dist-in 4.668 A628T,E767Q None None XRAY 1.8 0.201 0.233 B 311 287 20 0 0 0 [[481, 759]] 1.0 3b2t Homo sapiens TYR_FGFR2_HUMAN TYR 1.4e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 7OZYAAA P21802 467 762 821.0 47I:801 Type1 Inactive DFGin 6.618 14.218 BLAminus -128.08, -179.64 55.32, 74.91 -83.11, 15.08 289.1, 82.71 -52.3, -39.22 in-in in 7.535 Saltbr-in 2.859 HRD-in -77.89, -51.81 75.61, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.13, 18.52 APE9-dihe-in -94.81, 128.18 APE8-dihe-in -53.28, 119.61 APE8-rot-na 329.84 APE67-dihe-in -69.21, -9.08 -65.59, -32.88 APE12-dist-na 10.098 APE11-dist-na 10.628 APE10-dist-na 7.348 APE9-dist-in 4.663 None None None XRAY 2.28 0.243 0.296 AAA 303 281 15 0 0 0 [[481, 759]] 1.0 7ozy Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 7OZYBBB P21802 467 762 821.0 47I:801 Type1 Inactive DFGin 6.525 14.222 BLAminus -125.86, 176.96 60.82, 78.39 -85.84, 17.43 287.27, 80.93 -50.81, -42.13 in-in in 7.411 Saltbr-in 2.925 HRD-in -87.72, -51.8 77.6, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.889 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.37, 16.38 APE9-dihe-in -94.48, 132.52 APE8-dihe-in -58.52, 125.58 APE8-rot-na 337.9 APE67-dihe-in -78.03, -12.35 -66.5, -32.9 APE12-dist-na 9.938 APE11-dist-na 10.807 APE10-dist-na 7.34 APE9-dist-in 4.825 None None None XRAY 2.28 0.243 0.296 BBB 303 278 18 0 0 0 [[481, 759]] 1.0 7ozy Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8H75A P21802 467 765 821.0 KX0:1001 Type1 Inactive DFGin 7.213 14.585 BLAminus -154.63, 179.57 55.91, 54.1 -74.79, -3.2 274.96, 68.76 -58.48, -41.04 in-out in 7.417 Saltbr-out 4.811 HRD-out -96.67, 103.01 -67.39, -41.62 out-in-in SNCoii in-in ActLoopNT-in 3.141 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -162.98, 72.34 APE9-dihe-in -137.73, 148.36 APE8-dihe-in -71.99, 141.14 APE8-rot-na 343.8 APE67-dihe-in -63.34, -38.73 -70.52, -42.38 APE12-dist-na 13.018 APE11-dist-na 9.408 APE10-dist-na 7.3 APE9-dist-in 6.868 None PTR656 PTR656 XRAY 3.75 0.216 0.238 A 312 285 14 0 0 0 [[481, 759]] 1.0 8h75 Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8H75B P21802 467 764 821.0 KX0:1001 Type1 Inactive DFGin 7.114 15.321 BLAminus -140.03, -170.55 50.75, 50.66 -73.91, -10.21 273.73, 91.58 -58.96, -39.4 in-out in 7.468 Saltbr-out 4.436 HRD-in -64.7, -43.07 75.93, -2.73 out-in-out SNCoio in-out ActLoopNT-in 3.383 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.7, -40.57 APE9-dihe-in -143.97, 156.51 APE8-dihe-in -61.01, 137.3 APE8-rot-na 23.2 APE67-dihe-in -61.01, -38.56 -64.05, -38.82 APE12-dist-na 14.092 APE11-dist-na 11.287 APE10-dist-na 7.446 APE9-dist-in 5.738 None PTR656 PTR656 XRAY 3.75 0.216 0.238 B 312 283 15 0 0 0 [[481, 759]] 1.0 8h75 Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8H75C P21802 467 763 821.0 KX0:1001 Type1 Inactive DFGin 6.415 13.942 BLAminus -139.77, -171.25 51.94, 53.82 -68.52, 7.4 288.78, 82.18 -59.71, -35.71 in-in in 7.763 Saltbr-in 2.579 HRD-in -64.69, -38.41 67.2, 3.13 in-out-out SNCioo out-out ActLoopNT-out 3.788 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -86.06, 23.54 APE9-dihe-in -123.01, 141.76 APE8-dihe-in -64.83, 140.92 APE8-rot-na 351.7 APE67-dihe-in -63.43, -39.45 -65.53, -40.64 APE12-dist-na 10.784 APE11-dist-na 10.944 APE10-dist-na 7.514 APE9-dist-in 5.382 None PTR656 PTR656 XRAY 3.75 0.216 0.238 C 312 275 22 0 0 6 [[481, 759]] 1.0 8h75 Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8H75D P21802 467 764 821.0 KX0:1001 Type1 Inactive DFGin 6.719 14.006 BLAminus -145.79, -169.72 52.31, 64.06 -85.42, 2.67 285.45, 103.44 -59.5, -38.29 in-out in 7.69 Saltbr-out 4.357 HRD-in -66.94, -45.53 78.8, 0.63 out-in-out SNCoio in-out ActLoopNT-in 3.389 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 55.78, 41.43 APE9-dihe-in -144.13, 151.96 APE8-dihe-in -70.01, 128.38 APE8-rot-na 29.85 APE67-dihe-in -54.94, -35.54 -65.88, -42.6 APE12-dist-na 10.994 APE11-dist-na 11.053 APE10-dist-na 8.829 APE9-dist-in 5.759 None PTR656 PTR656 XRAY 3.75 0.216 0.238 D 312 277 21 0 0 4 [[481, 759]] 1.0 8h75 Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6LVKA P21802 468 766 821.0 EVC:801 Type1 Inactive DFGin 6.619 14.543 BLAminus -141.93, -174.02 55.34, 76.62 -90.82, 24.34 285.38, 77.37 -62.85, -30.59 in-in in 7.73 Saltbr-in 2.684 HRD-in -81.18, -49.18 75.66, -4.17 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.17, 17.9 APE9-dihe-in -89.66, 132.44 APE8-dihe-in -56.46, 117.97 APE8-rot-na 336.42 APE67-dihe-in -71.4, -11.53 -57.14, -41.35 APE12-dist-na 10.045 APE11-dist-na 10.809 APE10-dist-na 7.443 APE9-dist-in 4.936 None PTR561 PTR561 XRAY 2.29 0.206 0.247 A 313 288 11 0 0 0 [[481, 759]] 1.0 6lvk Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6LVKB P21802 468 765 821.0 EVC:801 Type1 Inactive DFGin 6.424 14.429 BLAminus -142.63, -167.55 46.22, 79.21 -86.53, 20.35 286.19, 75.54 -62.27, -23.76 in-in in 7.449 Saltbr-in 2.644 HRD-in -74.06, -49.98 75.98, -4.75 in-in-out SNCiio in-out ActLoopNT-in 2.806 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.0, 16.4 APE9-dihe-in -92.04, 132.11 APE8-dihe-in -55.72, 122.03 APE8-rot-na 331.04 APE67-dihe-in -82.5, -6.39 -64.61, -25.66 APE12-dist-na 10.161 APE11-dist-na 10.85 APE10-dist-na 7.496 APE9-dist-in 4.862 None PTR561 PTR561 XRAY 2.29 0.206 0.247 B 313 286 12 0 0 0 [[481, 759]] 1.0 6lvk Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6LVLA P21802 468 766 821.0 EVL:802 Type1 Inactive DFGin 6.609 14.53 BLAminus -146.15, -175.25 63.31, 72.06 -88.46, 19.6 283.4, 82.21 -53.64, -28.47 in-in in 7.721 Saltbr-in 2.632 HRD-in -74.18, -46.26 67.97, -0.94 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.16, 11.22 APE9-dihe-in -81.14, 133.04 APE8-dihe-in -57.2, 120.46 APE8-rot-na 339.92 APE67-dihe-in -68.23, -11.94 -62.32, -43.83 APE12-dist-na 10.163 APE11-dist-na 10.953 APE10-dist-na 7.536 APE9-dist-in 4.894 None None None XRAY 2.98 0.204 0.251 A 313 288 11 0 0 0 [[481, 759]] 1.0 6lvl Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6LVLB P21802 468 765 821.0 EVL:804 Type1 Inactive DFGin 6.504 14.379 BLAminus -137.97, -168.86 49.59, 89.79 -98.61, 21.56 282.72, 81.93 -60.4, -25.9 in-in in 7.476 Saltbr-in 2.773 HRD-in -74.99, -51.02 79.49, -6.99 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.2, 10.06 APE9-dihe-in -85.19, 131.23 APE8-dihe-in -58.17, 126.23 APE8-rot-na 336.1 APE67-dihe-in -79.35, -7.86 -72.73, -22.05 APE12-dist-na 10.031 APE11-dist-na 10.842 APE10-dist-na 7.447 APE9-dist-in 4.847 None None None XRAY 2.98 0.204 0.251 B 313 286 12 0 0 0 [[481, 759]] 1.0 6lvl Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 3RI1B P21802 468 766 821.0 3RH:1 Type1 Inactive DFGin 6.669 14.168 BLAminus -125.05, -168.18 44.8, 79.48 -91.34, 24.45 292.18, 85.49 -61.68, -38.04 in-in in 7.681 Saltbr-in 2.714 HRD-in -78.4, -46.06 72.66, -13.3 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.45, 15.65 APE9-dihe-in -96.94, 132.02 APE8-dihe-in -54.97, 122.14 APE8-rot-na 331.98 APE67-dihe-in -73.55, -6.33 -62.74, -38.58 APE12-dist-na 10.023 APE11-dist-na 10.84 APE10-dist-na 7.241 APE9-dist-in 5.005 None None None XRAY 2.1 0.216 0.247 B 313 283 16 0 0 0 [[481, 759]] 1.0 3ri1 Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 1OECA P21802 467 765 821.0 AA2:789 Type1 Inactive DFGin 6.387 13.79 BLAminus -124.86, -174.89 57.86, 79.24 -96.93, 23.45 302.8, 91.55 -64.89, -25.19 in-in in 7.359 Saltbr-in 2.798 HRD-in -70.07, -47.99 69.27, 1.07 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.98, 11.44 APE9-dihe-in -98.33, 142.87 APE8-dihe-in -64.53, 124.86 APE8-rot-na 24.49 APE67-dihe-in -66.61, -6.07 -58.62, -38.0 APE12-dist-na 10.059 APE11-dist-na 11.136 APE10-dist-na 7.546 APE9-dist-in 4.768 None None None XRAY 2.4 0.211 0.285 A 316 281 18 0 0 0 [[481, 759]] 1.0 1oec Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8SWEB P21802 468 767 821.0 WXQ:804 Type1 Inactive DFGin 6.362 14.39 BLAminus -138.39, -167.44 55.86, 63.6 -85.72, 22.79 292.14, 86.9 -64.13, -34.28 in-out in 7.84 Saltbr-out 3.615 HRD-in -78.85, -51.07 77.2, -7.67 out-in-out SNCoio in-out ActLoopNT-in 3.023 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.42, 18.52 APE9-dihe-in -97.67, 132.33 APE8-dihe-in -56.79, 133.06 APE8-rot-na 333.48 APE67-dihe-in -69.86, -7.28 -72.44, -38.73 APE12-dist-na 10.101 APE11-dist-na 10.797 APE10-dist-na 7.318 APE9-dist-in 4.892 None None None XRAY 2.24 0.212 0.25 B 316 288 12 0 0 0 [[481, 759]] 1.0 8swe Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 7KIAA P21802 467 764 821.0 WFD:801 Type1 Inactive DFGin 6.907 14.585 BLAminus -132.24, -172.32 57.59, 74.96 -99.72, 18.32 278.92, 79.54 -50.95, -35.45 in-in in 7.569 Saltbr-in 2.776 HRD-in -81.84, -48.19 75.32, -4.56 in-in-out SNCiio in-out ActLoopNT-in 2.907 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.81, 20.05 APE9-dihe-in -94.44, 131.06 APE8-dihe-in -58.4, 124.3 APE8-rot-na 334.14 APE67-dihe-in -73.93, -12.14 -62.31, -36.95 APE12-dist-na 9.889 APE11-dist-na 10.634 APE10-dist-na 7.311 APE9-dist-in 4.784 V564F None None XRAY 2.22 0.2 0.223 A 308 287 11 0 0 0 [[481, 759]] 1.0 7kia Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 7KIAB P21802 467 767 821.0 WFD:801 Type1 Inactive DFGin 6.992 14.509 BLAminus -132.54, -177.3 64.71, 67.38 -94.95, 24.82 285.24, 66.73 -55.57, -35.57 in-in in 7.506 Saltbr-in 2.868 HRD-in -82.16, -48.97 81.36, -8.74 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.27, 21.92 APE9-dihe-in -96.64, 130.19 APE8-dihe-in -51.06, 117.36 APE8-rot-na 325.83 APE67-dihe-in -72.33, -8.1 -58.88, -42.34 APE12-dist-na 9.986 APE11-dist-na 10.74 APE10-dist-na 7.352 APE9-dist-in 4.86 V564F None None XRAY 2.22 0.2 0.223 B 308 288 13 0 0 0 [[481, 759]] 1.0 7kia Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 7KIEA P21802 466 766 821.0 WF7:801 Type1 Inactive DFGin 6.977 14.848 BLAminus -131.39, -169.16 54.75, 74.84 -95.86, 20.26 282.29, 75.53 -45.07, -46.66 in-in in 7.611 Saltbr-in 3.048 HRD-in -91.29, -46.71 82.94, -9.97 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -125.11, 21.7 APE9-dihe-in -95.02, 131.64 APE8-dihe-in -52.4, 118.95 APE8-rot-na 324.83 APE67-dihe-in -75.99, -13.6 -53.13, -38.79 APE12-dist-na 10.033 APE11-dist-na 10.705 APE10-dist-na 7.483 APE9-dist-in 4.839 V564F None None XRAY 2.47 0.202 0.229 A 308 291 10 0 0 0 [[481, 759]] 1.0 7kie Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 7KIEB P21802 466 767 821.0 WF7:801 Type1 Inactive DFGin 7.035 14.809 BLAminus -137.38, -176.99 66.42, 65.65 -89.69, 13.43 284.31, 71.08 -48.41, -38.08 in-in in 7.448 Saltbr-in 3.232 HRD-in -77.26, -55.81 80.7, -9.45 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.89, 17.38 APE9-dihe-in -97.25, 125.97 APE8-dihe-in -52.01, 125.72 APE8-rot-na 329.53 APE67-dihe-in -76.39, -7.41 -69.78, -34.58 APE12-dist-na 10.09 APE11-dist-na 10.736 APE10-dist-na 7.332 APE9-dist-in 4.938 V564F None None XRAY 2.47 0.202 0.229 B 308 292 10 0 0 0 [[481, 759]] 1.0 7kie Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3BA P21802 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.161 13.792 BLAminus -144.89, -177.58 62.94, 96.35 -110.18, 24.57 301.57, 159.93 -61.44, -28.3 in-in in 7.866 Saltbr-in 2.964 HRD-in -87.0, -57.18 84.04, -4.97 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.51, 11.01 APE9-dihe-in -96.95, 136.95 APE8-dihe-in -62.98, 123.95 APE8-rot-na 335.72 APE67-dihe-in -70.54, -2.64 -63.47, -42.68 APE12-dist-na 999.0 APE11-dist-na 10.859 APE10-dist-na 7.224 APE9-dist-in 4.817 D650V None None XRAY 2.23 0.292 0.312 A 324 279 19 0 0 5 [[481, 759]] 1.0 8w3b Homo sapiens TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3BB P21802 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.18 13.86 BLAminus -144.53, -178.27 63.36, 96.56 -110.32, 24.83 301.28, 159.37 -61.06, -28.93 in-in in 7.884 Saltbr-in 2.965 HRD-in -86.57, -57.01 84.08, -5.72 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.04, 13.83 APE9-dihe-in -96.67, 136.92 APE8-dihe-in -63.18, 124.36 APE8-rot-na 337.68 APE67-dihe-in -70.88, -2.28 -62.39, -43.26 APE12-dist-na 999.0 APE11-dist-na 10.744 APE10-dist-na 7.23 APE9-dist-in 4.821 D650V None None XRAY 2.23 0.292 0.312 B 324 278 20 0 0 11 [[481, 759]] 1.0 8w3b Homo sapiens TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3BC P21802 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.13 13.838 BLAminus -145.32, -177.36 62.67, 96.38 -110.43, 24.64 301.15, 160.25 -61.18, -28.47 in-in in 7.826 Saltbr-in 2.968 HRD-in -87.03, -56.85 84.22, -5.5 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.46, 11.6 APE9-dihe-in -97.28, 136.65 APE8-dihe-in -63.45, 123.79 APE8-rot-na 336.35 APE67-dihe-in -70.29, -2.36 -62.67, -42.99 APE12-dist-na 999.0 APE11-dist-na 10.847 APE10-dist-na 7.207 APE9-dist-in 4.846 D650V None None XRAY 2.23 0.292 0.312 C 324 294 4 0 0 4 [[481, 759]] 1.0 8w3b Homo sapiens TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3BD P21802 465 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 6.111 13.867 BLAminus -145.2, -177.75 62.8, 96.65 -110.44, 24.68 301.04, 159.7 -61.39, -28.62 in-in in 7.857 Saltbr-in 2.962 HRD-in -87.13, -57.13 84.17, -5.75 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.01, 12.17 APE9-dihe-in -96.72, 136.82 APE8-dihe-in -63.08, 124.37 APE8-rot-na 337.6 APE67-dihe-in -71.49, -1.84 -62.33, -43.32 APE12-dist-na 999.0 APE11-dist-na 10.817 APE10-dist-na 7.235 APE9-dist-in 4.829 D650V None None XRAY 2.23 0.292 0.312 D 324 280 20 0 0 11 [[481, 759]] 1.0 8w3b Homo sapiens TYR_FGFR2_HUMAN TYR 9.8e-104 352.2 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3DA P21802 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.885 13.915 BLAminus -147.5, -176.54 60.37, 88.47 -102.26, 25.1 300.92, 154.4 -57.13, -34.04 in-in in 7.825 Saltbr-in 2.797 HRD-in -84.9, -54.51 77.26, 0.33 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.98, 12.82 APE9-dihe-in -97.28, 131.96 APE8-dihe-in -62.75, 115.5 APE8-rot-na 335.68 APE67-dihe-in -74.05, -8.17 -56.13, -41.02 APE12-dist-na 10.06 APE11-dist-na 11.173 APE10-dist-na 7.386 APE9-dist-in 4.984 N549K,D650V None None XRAY 2.04 0.22 0.25 A 324 298 0 0 0 0 [[481, 759]] 1.0 8w3d Homo sapiens TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3DB P21802 463 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.832 14.017 BLAminus -148.34, -176.74 60.99, 88.17 -102.41, 24.87 299.72, 154.97 -58.18, -33.84 in-in in 7.787 Saltbr-in 2.765 HRD-in -83.96, -54.88 76.41, -0.28 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.87, 19.37 APE9-dihe-in -95.98, 132.29 APE8-dihe-in -61.49, 116.39 APE8-rot-na 335.8 APE67-dihe-in -74.83, -7.73 -55.74, -41.43 APE12-dist-na 10.807 APE11-dist-na 10.914 APE10-dist-na 7.465 APE9-dist-in 4.97 N549K,D650V None None XRAY 2.04 0.22 0.25 B 324 286 16 0 0 7 [[481, 759]] 1.0 8w3d Homo sapiens TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3DC P21802 467 766 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.855 13.9 BLAminus -147.64, -176.09 60.07, 88.49 -102.13, 25.05 300.63, 154.01 -57.64, -33.63 in-in in 7.772 Saltbr-in 2.793 HRD-in -84.16, -54.95 77.08, 0.92 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.76, 14.01 APE9-dihe-in -96.42, 131.36 APE8-dihe-in -63.38, 115.02 APE8-rot-na 334.88 APE67-dihe-in -73.92, -8.44 -56.07, -40.69 APE12-dist-na 10.113 APE11-dist-na 11.132 APE10-dist-na 7.426 APE9-dist-in 4.986 N549K,D650V None None XRAY 2.04 0.22 0.25 C 324 300 0 0 0 0 [[481, 759]] 1.0 8w3d Homo sapiens TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W3DD P21802 463 765 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.812 14.007 BLAminus -147.99, -176.89 61.0, 88.35 -102.2, 24.75 299.43, 154.83 -57.77, -34.3 in-in in 7.773 Saltbr-in 2.759 HRD-in -84.08, -54.96 76.09, 0.5 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.21, 21.5 APE9-dihe-in -95.42, 132.82 APE8-dihe-in -60.81, 115.91 APE8-rot-na 335.81 APE67-dihe-in -74.61, -8.25 -55.74, -40.98 APE12-dist-na 10.799 APE11-dist-na 10.925 APE10-dist-na 7.589 APE9-dist-in 4.967 N549K,D650V None None XRAY 2.04 0.22 0.25 D 324 296 7 0 0 2 [[481, 759]] 1.0 8w3d Homo sapiens TYR_FGFR2_HUMAN TYR 6.7e-104 352.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6AGXA P21802 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.385 13.771 BLAminus -135.61, -178.23 50.32, 94.72 -100.36, 28.49 297.32, 121.17 -57.47, -52.54 in-out in 8.0 Saltbr-out 3.657 HRD-in -93.88, -57.68 78.68, 6.68 out-in-in SNCoii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.5, 54.14 APE9-dihe-in -114.81, 139.22 APE8-dihe-in -71.75, 130.63 APE8-rot-na 345.91 APE67-dihe-in -76.18, -12.01 -73.34, -35.43 APE12-dist-na 13.53 APE11-dist-na 9.065 APE10-dist-na 7.568 APE9-dist-in 4.596 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 A 298 285 13 0 0 5 [[481, 759]] 1.0 6agx Homo sapiens TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6AGXB P21802 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.405 14.025 BLAminus -135.35, -176.95 51.01, 93.04 -100.6, 27.53 298.31, 119.25 -60.39, -50.86 in-out in 7.961 Saltbr-out 4.38 HRD-in -94.17, -57.95 78.91, 4.09 out-in-out SNCoio in-out ActLoopNT-in 2.949 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.86, 49.42 APE9-dihe-in -113.92, 143.72 APE8-dihe-in -70.47, 130.2 APE8-rot-na 344.64 APE67-dihe-in -74.99, -12.99 -75.16, -33.86 APE12-dist-na 14.503 APE11-dist-na 9.856 APE10-dist-na 7.732 APE9-dist-in 4.697 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 B 298 298 0 0 0 0 [[481, 759]] 1.0 6agx Homo sapiens TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6AGXC P21802 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.39 13.803 BLAminus -136.28, -175.68 48.02, 94.4 -101.25, 28.5 296.6, 120.3 -58.43, -51.67 in-out in 7.916 Saltbr-out 3.662 HRD-in -93.94, -57.46 79.08, 5.82 out-in-in SNCoii in-in ActLoopNT-in 2.951 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.39, 66.84 APE9-dihe-in -120.25, 138.55 APE8-dihe-in -72.11, 130.82 APE8-rot-na 346.01 APE67-dihe-in -76.61, -11.72 -72.7, -35.99 APE12-dist-na 14.141 APE11-dist-na 9.191 APE10-dist-na 7.7 APE9-dist-in 4.7 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 C 298 284 14 0 0 5 [[481, 759]] 1.0 6agx Homo sapiens TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6AGXD P21802 467 764 821.0 9WX:800 Type1.5_Back Inactive DFGin 6.355 13.94 BLAminus -136.3, -175.46 49.29, 93.64 -101.17, 27.37 298.51, 119.67 -59.92, -50.84 in-out in 7.975 Saltbr-out 3.689 HRD-in -94.2, -57.48 79.52, 3.16 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.04, 47.47 APE9-dihe-in -113.88, 141.66 APE8-dihe-in -70.17, 130.94 APE8-rot-na 346.46 APE67-dihe-in -73.96, -13.6 -74.55, -33.23 APE12-dist-na 14.283 APE11-dist-na 9.82 APE10-dist-na 7.608 APE9-dist-in 4.719 A628T PTR586,PTR588,PTR656,PTR657 PTR586,PTR588,PTR656,PTR657 XRAY 2.95 0.254 0.298 D 298 298 0 0 0 0 [[481, 759]] 1.0 6agx Homo sapiens TYR_FGFR2_HUMAN TYR 1.2e-103 351.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 3RI1A P21802 468 765 821.0 3RH:2 Type1.5_Back Inactive DFGin 6.832 14.17 BLAminus -123.23, -170.67 54.24, 75.33 -95.71, 30.48 294.51, 86.16 -72.01, -31.85 in-in in 7.756 Saltbr-in 2.712 HRD-in -81.62, -48.44 74.58, -5.16 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.86, 17.26 APE9-dihe-in -94.17, 130.86 APE8-dihe-in -56.98, 120.47 APE8-rot-na 333.82 APE67-dihe-in -73.48, -11.98 -59.18, -36.04 APE12-dist-na 9.865 APE11-dist-na 10.71 APE10-dist-na 7.382 APE9-dist-in 4.842 None None None XRAY 2.1 0.216 0.247 A 313 285 13 0 0 0 [[481, 759]] 1.0 3ri1 Homo sapiens TYR_FGFR2_HUMAN TYR 2.5e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W38A P21802 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.884 13.939 BLAminus -141.73, -172.44 58.43, 85.09 -99.65, 33.03 296.5, 153.04 -60.44, -42.96 in-in in 7.716 Saltbr-in 2.73 HRD-in -67.46, -57.27 77.66, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.69, 6.19 APE9-dihe-in -92.48, 138.52 APE8-dihe-in -67.31, 130.89 APE8-rot-na 342.55 APE67-dihe-in -76.49, 2.73 -63.26, -44.89 APE12-dist-na 9.938 APE11-dist-na 10.863 APE10-dist-na 7.187 APE9-dist-in 4.84 N549D,D650V None None XRAY 2.6 0.337 0.359 A 324 298 0 0 0 0 [[481, 759]] 1.0 8w38 Homo sapiens TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W38B P21802 467 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.917 13.867 BLAminus -141.61, -172.11 58.71, 84.88 -99.53, 33.01 296.86, 151.72 -60.67, -42.8 in-in in 7.677 Saltbr-in 2.736 HRD-in -66.89, -57.79 77.67, 7.38 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.73, 7.76 APE9-dihe-in -92.14, 138.79 APE8-dihe-in -66.97, 130.73 APE8-rot-na 341.51 APE67-dihe-in -76.67, 2.98 -63.37, -44.91 APE12-dist-na 9.766 APE11-dist-na 10.751 APE10-dist-na 7.194 APE9-dist-in 4.826 N549D,D650V None None XRAY 2.6 0.337 0.359 B 324 288 10 0 0 6 [[481, 759]] 1.0 8w38 Homo sapiens TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W38C P21802 465 764 821.0 TZ0:801 Type1.5_Back Inactive DFGin 5.905 14.001 BLAminus -141.73, -172.23 58.36, 85.55 -99.69, 32.51 297.47, 150.87 -60.14, -43.03 in-in in 7.766 Saltbr-in 2.733 HRD-in -67.3, -57.38 78.5, 5.79 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.74, 8.72 APE9-dihe-in -90.56, 139.47 APE8-dihe-in -66.09, 130.7 APE8-rot-na 342.51 APE67-dihe-in -75.82, 2.85 -65.85, -41.6 APE12-dist-na 999.0 APE11-dist-na 10.65 APE10-dist-na 7.238 APE9-dist-in 4.776 N549D,D650V None None XRAY 2.6 0.337 0.359 C 324 289 11 0 0 11 [[481, 759]] 1.0 8w38 Homo sapiens TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W38D P21802 467 764 821.0 TZ0:800 Type1.5_Back Inactive DFGin 5.958 13.994 BLAminus -141.63, -172.13 58.59, 85.21 -99.57, 33.16 297.38, 150.22 -60.22, -43.6 in-in in 7.782 Saltbr-in 2.764 HRD-in -66.88, -57.89 78.41, 5.63 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.9, 7.03 APE9-dihe-in -91.06, 139.7 APE8-dihe-in -66.27, 130.75 APE8-rot-na 343.36 APE67-dihe-in -75.84, 2.91 -65.4, -41.85 APE12-dist-na 999.0 APE11-dist-na 10.75 APE10-dist-na 7.22 APE9-dist-in 4.794 N549D,D650V None None XRAY 2.6 0.337 0.359 D 324 271 27 0 0 11 [[481, 759]] 1.0 8w38 Homo sapiens TYR_FGFR2_HUMAN TYR 1.5e-103 351.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8E1XA P21802 468 762 821.0 U9P:801 Type1 Inactive DFGin 5.029 12.823 BLAplus -132.17, 165.27 55.8, 54.52 -100.25, -11.66 52.62, 78.71 -98.93, 9.55 in-in in 8.036 Saltbr-in 2.644 HRD-in -82.17, -50.15 76.34, -11.07 in-out-out SNCioo out-out ActLoopNT-out 8.222 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -128.31, 147.09 APE9-dihe-in -97.44, 99.33 APE8-dihe-out -63.81, -11.62 APE8-rot-na 338.3 APE67-dihe-in -73.9, -4.36 -70.48, -21.94 APE12-dist-na 14.85 APE11-dist-na 18.906 APE10-dist-na 16.364 APE9-dist-out 11.465 None PTR561,PTR586 PTR561,PTR586 XRAY 2.68 0.226 0.272 A 330 290 5 0 0 5 [[481, 759]] 1.0 8e1x Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8E1XB P21802 467 765 821.0 U9P:801 Type1 Inactive DFGin 5.691 12.618 BLAplus -131.15, 165.03 56.01, 52.0 -100.91, -14.67 45.9, 85.31 -101.29, 8.07 in-in in 8.079 Saltbr-in 3.074 HRD-in -82.51, -51.1 78.17, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.514 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -131.92, 152.55 APE9-dihe-in -96.57, 103.24 APE8-dihe-out -60.48, -10.56 APE8-rot-na 339.07 APE67-dihe-in -76.23, -2.9 -70.07, -24.1 APE12-dist-na 14.925 APE11-dist-na 19.439 APE10-dist-na 17.481 APE9-dist-out 11.322 None PTR561,PTR586 PTR561,PTR586 XRAY 2.68 0.226 0.272 B 330 293 6 0 0 2 [[481, 759]] 1.0 8e1x Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8STGA P21802 461 764 821.0 WCJ:801 Type1 Inactive DFGin 5.59 12.888 BLAplus -145.36, 157.52 90.77, 4.11 -67.5, -2.28 57.4, 70.91 -126.28, 999.0 in-out in 8.184 Saltbr-out 4.606 HRD-out -102.42, 117.61 -61.0, -55.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -15.95 APE9-dihe-in -134.91, 146.08 APE8-dihe-in -92.36, 82.18 APE8-rot-na 24.23 APE67-dihe-in -66.95, -23.69 -61.29, -38.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.907 None None None XRAY 3.79 0.307 0.311 A 317 277 27 0 0 17 [[481, 759]] 1.0 8stg Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 9U3NA P21802 461 764 821.0 A1ENT:801 Type1 Inactive DFGin 5.818 12.949 BLAplus -102.48, 156.56 123.79, -13.39 -63.25, -8.77 52.43, 90.85 -152.53, 999.0 in-out in 8.178 Saltbr-out 4.631 HRD-out -98.51, 122.94 -65.62, -59.12 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.33, 167.8 APE9-dihe-in -100.91, 125.49 APE8-dihe-in -74.9, 91.59 APE8-rot-na 32.92 APE67-dihe-in -76.06, -19.15 -78.78, -31.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.66 V564F None None XRAY 3.25 0.283 0.342 A 311 276 28 0 0 15 [[481, 759]] 1.0 9u3n Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W2XA P21802 458 765 821.0 A1AFR:60801 Type1.5_Back Inactive DFGin 5.186 13.347 BLAplus -120.4, 170.08 47.84, 47.71 -101.14, -15.65 62.51, 79.97 -87.59, -18.95 in-in in 8.011 Saltbr-in 2.948 HRD-in -69.21, -58.65 84.1, -5.97 in-out-out SNCioo out-out ActLoopNT-out 8.558 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.12, 147.0 APE9-dihe-in -116.78, 92.64 APE8-dihe-out -53.69, -17.45 APE8-rot-na 330.1 APE67-dihe-in -71.44, -10.68 -63.08, -26.44 APE12-dist-na 19.353 APE11-dist-na 21.562 APE10-dist-na 17.572 APE9-dist-out 11.588 None None None XRAY 2.98 0.211 0.237 A 324 304 4 0 0 0 [[481, 759]] 1.0 8w2x Homo sapiens TYR_FGFR2_HUMAN TYR 6.2e-104 352.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8W2XB P21802 458 765 821.0 A1AFR:60801 Type1.5_Back Inactive DFGin 5.172 13.672 BLAplus -120.88, 172.87 46.97, 47.43 -101.96, -10.72 62.07, 80.77 -85.12, -16.26 in-in in 8.256 Saltbr-in 3.578 HRD-in -69.81, -58.19 83.73, -4.52 in-out-out SNCioo out-out ActLoopNT-out 7.566 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.55, 151.04 APE9-dihe-in -117.66, 89.73 APE8-dihe-out -57.08, -16.9 APE8-rot-na 336.97 APE67-dihe-in -70.95, -11.38 -63.76, -26.5 APE12-dist-na 19.294 APE11-dist-na 21.709 APE10-dist-na 18.148 APE9-dist-out 11.385 None None None XRAY 2.98 0.211 0.237 B 324 291 17 0 0 3 [[481, 759]] 1.0 8w2x Homo sapiens TYR_FGFR2_HUMAN TYR 6.2e-104 352.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8U1FA P21802 460 764 821.0 UIM:802 Type1.5_Back Inactive DFGin 5.799 12.234 BLAplus -115.66, -167.23 57.04, 20.36 -74.9, -7.44 38.26, 84.93 19.48, 999.0 in-out in 7.802 Saltbr-out 4.269 HRD-out -85.43, 135.13 -70.56, -48.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -64.66 APE9-dihe-in -61.23, 136.11 APE8-dihe-in -91.89, 60.04 APE8-rot-na 32.99 APE67-dihe-in -62.46, -7.58 -55.89, -38.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.28 None None None XRAY 3.33 0.269 0.295 A 316 276 29 0 0 17 [[481, 759]] 1.0 8u1f Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 6V6QC P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.766 13.643 BLBminus -136.89, -177.89 59.28, 74.24 -85.91, -161.66 300.29, 95.93 81.23, -12.62 in-in in 7.463 Saltbr-in 3.314 HRD-in -72.01, -47.4 74.74, -13.46 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.47, 28.67 APE9-dihe-in -111.04, 128.94 APE8-dihe-in -52.92, 121.96 APE8-rot-na 327.46 APE67-dihe-in -69.24, -12.82 -58.84, -37.31 APE12-dist-na 999.0 APE11-dist-na 10.498 APE10-dist-na 7.431 APE9-dist-in 5.088 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 C 411 279 21 0 0 11 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8U1FB P21802 472 765 821.0 UIM:802 Type1.5_Back Inactive DFGin 6.244 12.702 None -124.83, 24.9 -143.72, 116.95 -174.75, 141.2 47.25, 98.48 -120.17, -141.34 in-out in 7.179 Saltbr-out 5.47 HRD-out -91.63, 125.64 -83.89, -44.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.43 APE8-dihe-in -82.13, 67.06 APE8-rot-na 35.42 APE67-dihe-in -61.84, -12.32 -56.83, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.201 None None None XRAY 3.33 0.269 0.295 B 316 268 26 0 0 16 [[481, 759]] 1.0 8u1f Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 8STGB P21802 472 765 821.0 WCJ:801 Type1.5_Back Inactive DFGin 5.748 12.473 None -146.69, 51.17 -166.05, 99.26 -159.05, 129.25 42.24, 92.9 -129.91, 121.06 in-out in 7.518 Saltbr-out 4.961 HRD-out -109.82, 96.26 -71.43, -48.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 71.23, -15.79 APE9-dihe-in -138.41, 153.88 APE8-dihe-in -76.95, 77.58 APE8-rot-na 30.06 APE67-dihe-in -68.25, -27.71 -60.57, -41.19 APE12-dist-na 23.596 APE11-dist-na 24.226 APE10-dist-na 21.813 APE9-dist-in 7.303 None None None XRAY 3.79 0.307 0.311 B 317 274 20 0 0 10 [[481, 759]] 1.0 8stg Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
FGFR2_HUMAN 9U3NB P21802 470 764 821.0 A1ENT:801 Type1.5_Back Inactive DFGin 5.761 12.952 None -150.15, 37.07 -124.69, 18.17 -79.98, -34.12 48.54, 88.69 -70.14, 999.0 in-in in 7.94 Saltbr-in 3.377 HRD-out -109.06, 108.36 -99.86, 137.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -159.89, 170.93 APE9-dihe-in -97.33, 137.9 APE8-dihe-in -78.65, 61.34 APE8-rot-na 34.6 APE67-dihe-in -58.88, -28.65 -55.23, -53.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.659 V564F None None XRAY 3.25 0.283 0.342 B 311 272 23 0 0 13 [[481, 759]] 1.0 9u3n Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2

TYR_FGFR2 (Fibroblast growth factor receptor 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name