TYR_EPHA3 (Ephrin type-A receptor 3)

Total number of chains: 29
Active chains: 2
Uniprot: EPHA3_HUMAN
Kinase Domain Residues: 621 - 880
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 69.0% AF-P29320-K1A
DFGin None 6 20.7% 2QODA
DFGout None 2 6.9% 4TWNA
DFGout BBAminus 1 3.4% 3DZQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P29320-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 613 - 888 0 None None Ephrin type-A receptor 3
AF-P29320-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 613 - 888 0 None None Ephrin type-A receptor 3
2QOCA 1.25 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 613 - 906 0 None None Ephrin type-A receptor 3
3FXXA 1.7 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 606 - 904 0 None A608T Ephrin type-A receptor 3
2QO7A 1.605 Inactive DFGin‑BLAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 595 - 904 0 PTR701 None Ephrin type-A receptor 3
2QO9A 1.55 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_noiai APEdist_aaai ANP ATPlike 608 - 904 0 None None Ephrin type-A receptor 3
2QOBA 1.65 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 609 - 906 0 PTR701 None Ephrin type-A receptor 3
3FY2A 1.8 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 607 - 904 0 None A608T Ephrin type-A receptor 3
2QO2A 1.6 Inactive DFGin‑BLAminus in-in none-out TYR APEdihe_nnnao APEdist_aaan No_ligand No_ligand 595 - 904 0 None None Ephrin type-A receptor 3
2QONA 1.79 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 595 - 905 0 PTR701 Y596F,Y602F,Y742A Ephrin type-A receptor 3
6IN0A 1.501 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai O4B, O4B Type3, Allosteric 613 - 903 0 None None Ephrin type-A receptor 3
2QOOA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,Y742F Ephrin type-A receptor 3
2QOFA 1.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 906 0 None Y596F Ephrin type-A receptor 3
2QODA 1.15 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y602F Ephrin type-A receptor 3
2QOIA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F Ephrin type-A receptor 3
2QOLA 1.07 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,S768G Ephrin type-A receptor 3
4P4CA 1.599 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 25Q Type1 613 - 904 0 None None Ephrin type-A receptor 3
3DZQA 1.75 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan IFC Type2 609 - 904 0 None None Ephrin type-A receptor 3
4P5ZA 2.002 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan Q7M Type2 609 - 903 0 None None Ephrin type-A receptor 3
4TWNA 1.706 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai B96 Type2 609 - 904 0 None None Ephrin type-A receptor 3
2QOQA 1.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 595 - 906 0 PTR701 None Ephrin type-A receptor 3
2GSFA 1.77 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None A608T Ephrin type-A receptor 3
2QOKA 1.2 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,S768A Ephrin type-A receptor 3
4GK3A 1.898 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai L87 Type1 609 - 903 0 None None Ephrin type-A receptor 3
4P5QA 1.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai Q0B Type1 609 - 904 0 None None Ephrin type-A receptor 3
4TWOA 2.047 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 37W Type1 609 - 906 0 None None Ephrin type-A receptor 3
4G2FA 1.699 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan C07 Type1.5_Back 609 - 903 0 None None Ephrin type-A receptor 3
4GK2A 2.195 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan L66 Type1.5_Back 609 - 903 0 None None Ephrin type-A receptor 3
4GK4A 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai L90 Type1.5_Back 609 - 903 0 None None Ephrin type-A receptor 3

TYR_EPHA3 (Ephrin type-A receptor 3)

Total number of chains: 29
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 69.0% AF-P29320-K1A
DFGin None 6 20.7% 2QODA
DFGout None 2 6.9% 4TWNA
DFGout BBAminus 1 3.4% 3DZQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
EPHA3_HUMAN AF-P29320-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 613 - 888 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN AF-P29320-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 613 - 888 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOCA 1.25 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 613 - 906 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 3FXXA 1.7 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 606 - 904 0 None A608T Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QO7A 1.605 Inactive DFGin‑BLAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 595 - 904 0 PTR701 None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QO9A 1.55 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_noiai APEdist_aaai ANP ATPlike 608 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOBA 1.65 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 609 - 906 0 PTR701 None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 3FY2A 1.8 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 607 - 904 0 None A608T Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QO2A 1.6 Inactive DFGin‑BLAminus in-in none-out TYR APEdihe_nnnao APEdist_aaan No_ligand No_ligand 595 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QONA 1.79 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 595 - 905 0 PTR701 Y596F,Y602F,Y742A Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 6IN0A 1.501 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_nniai APEdist_aaai O4B, O4B Type3, Allosteric 613 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOOA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,Y742F Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOFA 1.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 906 0 None Y596F Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QODA 1.15 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y602F Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOIA 1.25 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOLA 1.07 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,S768G Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4P4CA 1.599 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 25Q Type1 613 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 3DZQA 1.75 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan IFC Type2 609 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4P5ZA 2.002 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan Q7M Type2 609 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4TWNA 1.706 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai B96 Type2 609 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOQA 1.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 595 - 906 0 PTR701 None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2GSFA 1.77 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 595 - 904 0 None A608T Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 2QOKA 1.2 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 595 - 904 0 None Y596F,Y602F,S768A Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4GK3A 1.898 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai L87 Type1 609 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4P5QA 1.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai Q0B Type1 609 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4TWOA 2.047 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 37W Type1 609 - 906 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4G2FA 1.699 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan C07 Type1.5_Back 609 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4GK2A 2.195 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan L66 Type1.5_Back 609 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens
EPHA3_HUMAN 4GK4A 2.1 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai L90 Type1.5_Back 609 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens

TYR_EPHA3 (Ephrin type-A receptor 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism