TYR_EPHA3 (Ephrin type-A receptor 3)

Total number of chains: 29
Active chains: 2
Family: TYR
Uniprot: EPHA3_HUMAN
Kinase Domain Residues: 621 - 880
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 69.0% AF-P29320-K1A
DFGin None 6 20.7% 2QODA
DFGout None 2 6.9% 4TWNA
DFGout BBAminus 1 3.4% 3DZQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P29320-K1A 613 888 983.0 No_ligand No_ligand Active DFGin 5.965 14.207 BLAminus -140.17, 176.14 64.75, 67.74 -84.89, 12.18 298.41, 93.53 -59.25, -34.26 in-in in 8.104 Saltbr-in 2.716 HRD-in -76.92, -44.9 68.93, -11.94 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.71, 137.86 APE9-dihe-in -117.09, 122.76 APE8-dihe-in -75.6, 83.17 APE8-rot-na 33.33 APE67-dihe-in -68.16, -18.52 -43.46, -48.96 APE12-dist-na 11.002 APE11-dist-na 8.699 APE10-dist-na 9.461 APE9-dist-in 6.179 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[621, 880]] 1.0 AF-P29320-K1 TYR_EPHA3_HUMAN TYR 3.9e-111 376.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
AF-P29320-K3A 613 888 983.0 No_ligand No_ligand Active DFGin 5.996 14.445 BLAminus -143.09, -179.44 62.4, 65.79 -80.18, 9.38 292.91, 97.16 -59.5, -31.3 in-in in 8.069 Saltbr-in 2.678 HRD-in -79.18, -46.7 71.28, -7.59 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.11, 145.03 APE9-dihe-in -123.06, 131.23 APE8-dihe-in -76.8, 78.27 APE8-rot-na 34.09 APE67-dihe-in -65.23, -16.26 -42.71, -48.59 APE12-dist-na 11.534 APE11-dist-na 9.196 APE10-dist-na 9.937 APE9-dist-in 6.324 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[621, 880]] 1.0 AF-P29320-K3 TYR_EPHA3_HUMAN TYR 3.9e-111 376.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOCA 613 906 983.0 ANP:949 ATPlike Inactive DFGin 4.995 15.445 BLAminus -141.69, -171.73 58.63, 84.29 -97.26, 21.84 297.12, 103.61 -61.69, -31.71 in-out in 9.495 Saltbr-out 6.048 HRD-in -71.05, -48.03 74.01, -8.74 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 135.66 APE9-dihe-in -81.0, 137.87 APE8-dihe-in -77.44, 99.9 APE8-rot-na 34.81 APE67-dihe-in -63.09, -22.76 -54.0, -44.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.214 APE9-dist-in 5.514 None None None XRAY 1.25 0.17 0.186 A 344 283 11 0 0 11 [[621, 880]] 1.0 2qoc TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
3FXXA 606 904 983.0 ANP:992 ATPlike Inactive DFGin 4.9 15.171 BLAminus -132.57, -176.13 56.24, 78.37 -91.43, 22.66 298.54, 96.01 -59.15, -30.35 in-out in 9.376 Saltbr-out 4.254 HRD-in -72.67, -46.91 76.32, -4.64 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.39, 147.18 APE9-dihe-in -116.01, 151.61 APE8-dihe-in -77.44, 77.25 APE8-rot-na 30.85 APE67-dihe-in -60.25, -20.23 -50.19, -49.06 APE12-dist-na 999.0 APE11-dist-na 8.999 APE10-dist-na 10.183 APE9-dist-in 6.238 A608T None None XRAY 1.7 0.168 0.194 A 371 288 9 0 0 9 [[621, 880]] 1.0 3fxx TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QO7A 595 904 983.0 ANP:1000 ATPlike Inactive DFGin 5.481 15.556 BLAminus -130.76, -168.32 68.6, 58.57 -92.37, 46.9 297.61, 96.94 -87.84, 999.0 in-out in 8.4 Saltbr-out 4.348 HRD-in -73.41, -45.48 73.79, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.99 APE8-rot-na 29.77 APE67-dihe-in -61.7, -25.84 -53.26, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR701 PTR701 XRAY 1.605 0.186 0.224 A 373 279 20 0 0 20 [[621, 880]] 1.0 2qo7 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QO9A 608 904 983.0 ANP:948 ATPlike Inactive DFGin 5.205 15.375 BLAminus -133.34, -177.89 59.05, 80.14 -92.65, 15.74 295.85, 100.25 -55.83, -40.55 in-out in 9.235 Saltbr-out 4.23 HRD-in -71.62, -45.86 73.18, -10.67 out-in-out SNCoio in-out ActLoopNT-in 2.997 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 105.46 APE9-dihe-out 41.85, 78.2 APE8-dihe-in -71.02, 94.17 APE8-rot-na 29.94 APE67-dihe-in -61.69, -23.23 -54.76, -43.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.168 APE9-dist-in 5.854 None None None XRAY 1.55 0.183 0.211 A 373 277 13 0 0 13 [[621, 880]] 1.0 2qo9 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOBA 609 906 983.0 No_ligand No_ligand Inactive DFGin 5.066 14.928 BLAminus -139.34, -172.16 58.85, 83.97 -96.38, 20.44 301.06, 100.21 -60.34, -35.17 in-out in 8.954 Saltbr-out 4.319 HRD-in -74.47, -48.3 72.91, -7.69 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -49.79 APE9-dihe-in -72.25, 128.89 APE8-dihe-in -78.68, 90.62 APE8-rot-na 31.34 APE67-dihe-in -62.26, -23.36 -52.95, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.098 APE9-dist-in 5.953 None PTR701 PTR701 XRAY 1.65 0.17 0.196 A 344 281 13 0 0 13 [[621, 880]] 1.0 2qob TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
3FY2A 607 904 983.0 No_ligand No_ligand Inactive DFGin 5.001 15.145 BLAminus -134.96, -176.32 58.57, 75.9 -90.06, 19.9 298.27, 99.27 -58.2, -34.52 in-out in 9.255 Saltbr-out 3.762 HRD-in -69.79, -49.72 73.39, -4.5 out-in-in SNCoii in-in ActLoopNT-in 2.995 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.03, 136.16 APE9-dihe-in -109.97, 152.44 APE8-dihe-in -78.29, 81.42 APE8-rot-na 30.96 APE67-dihe-in -61.02, -19.58 -53.79, -46.87 APE12-dist-na 999.0 APE11-dist-na 9.092 APE10-dist-na 10.203 APE9-dist-in 6.346 A608T None None XRAY 1.8 0.181 0.212 A 371 285 10 0 0 10 [[621, 880]] 1.0 3fy2 TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QO2A 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.584 16.12 BLAminus -131.8, -165.29 66.45, 65.03 -102.63, 10.59 295.47, 102.56 -82.74, 999.0 in-in in 8.355 Saltbr-in 2.694 HRD-in -72.66, -47.05 74.97, -15.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.34 APE8-rot-na 320.93 APE67-dihe-out -61.72, -23.71 166.11, -52.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.177 0.203 A 373 282 20 0 0 20 [[621, 880]] 1.0 2qo2 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QONA 595 905 983.0 No_ligand No_ligand Inactive DFGin 5.067 15.854 BLAminus -131.83, 179.54 60.62, 74.52 -94.47, 24.38 299.54, 95.48 -58.75, -38.51 in-out in 9.296 Saltbr-out 4.112 HRD-in -72.22, -48.07 71.7, -10.11 out-in-none SNCoin in-none ActLoopNT-in 2.853 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.56 APE8-dihe-in -66.11, 89.51 APE8-rot-na 28.14 APE67-dihe-in -62.78, -22.64 -52.51, -42.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.262 Y596F,Y602F,Y742A PTR701 PTR701 XRAY 1.79 0.175 0.191 A 373 282 16 0 0 16 [[621, 880]] 1.0 2qon TYR_EPHA3_HUMAN TYR 4.8e-110 372.9 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
6IN0A 613 903 983.0 O4B:1003,O4B:1004 Type3,Allosteric Inactive DFGin 4.986 15.861 BLAminus -133.21, -172.75 59.01, 74.39 -87.51, 7.85 292.48, 90.28 -50.7, -40.3 in-out in 9.579 Saltbr-out 4.943 HRD-in -74.58, -48.98 74.89, -18.28 out-in-none SNCoin in-none ActLoopNT-in 2.955 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.77 APE8-dihe-in -75.79, 85.61 APE8-rot-na 30.12 APE67-dihe-in -60.41, -27.1 -48.99, -47.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.242 None None None XRAY 1.501 0.197 0.229 A 301 272 14 0 0 14 [[621, 880]] 1.0 6in0 TYR_EPHA3_HUMAN TYR 5.3e-111 376.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOOA 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.57 16.139 None -130.25, -171.33 69.56, 59.1 -97.35, 999.0 296.3, 100.28 999.0, 999.0 in-in in 8.844 Saltbr-in 2.167 HRD-in -71.72, -46.92 71.95, -7.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -147.9 APE8-rot-na 327.21 APE67-dihe-in -60.63, -26.51 -52.34, -45.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,Y742F None None XRAY 1.25 0.19 0.202 A 373 273 21 0 0 21 [[621, 880]] 1.0 2qoo TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOFA 595 906 983.0 No_ligand No_ligand Inactive DFGin 5.574 16.154 None -128.85, -171.0 68.65, 68.64 -106.11, 999.0 294.29, 100.28 999.0, 999.0 in-in in 8.483 Saltbr-in 2.866 HRD-in -71.61, -47.44 75.56, -15.18 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.26 APE8-rot-na 32.87 APE67-dihe-in -60.72, -24.96 -52.12, -45.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F None None XRAY 1.2 0.182 0.195 A 373 280 21 0 0 21 [[621, 880]] 1.0 2qof TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QODA 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.547 16.055 None -131.77, -171.54 68.49, 69.41 -105.64, 999.0 292.55, 100.77 999.0, 999.0 in-in in 8.459 Saltbr-in 2.977 HRD-in -71.92, -47.0 75.02, -14.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.55 APE8-rot-na 32.64 APE67-dihe-in -61.1, -23.78 -54.99, -44.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y602F None None XRAY 1.15 0.193 0.206 A 373 274 21 0 0 21 [[621, 880]] 1.0 2qod TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOIA 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.619 16.256 None -129.96, -173.84 70.71, 70.9 -110.19, 999.0 293.26, 97.85 999.0, 999.0 in-in in 8.916 Saltbr-in 2.155 HRD-in -70.57, -48.64 76.1, -13.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.52 APE8-rot-na 29.06 APE67-dihe-in -60.23, -25.5 -51.78, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.25 0.186 0.192 A 373 274 21 0 0 21 [[621, 880]] 1.0 2qoi TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOLA 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.53 15.953 None -127.91, -172.59 67.31, 78.66 -111.91, 999.0 291.32, 93.34 999.0, 999.0 in-in in 8.426 Saltbr-in 3.115 HRD-in -70.18, -47.4 74.82, -14.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -61.36, -24.47 999.0, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,S768G None None XRAY 1.07 0.196 0.211 A 373 273 22 0 0 22 [[621, 880]] 1.0 2qol TYR_EPHA3_HUMAN TYR 3.8e-110 373.3 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4P4CA 613 904 983.0 25Q:1001 Type1 Inactive DFGin 5.482 15.719 None -128.35, -167.77 63.56, 68.23 -102.55, 999.0 294.45, 99.08 999.0, 999.0 in-in in 8.262 Saltbr-in 2.859 HRD-in -69.2, -49.45 78.06, -9.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.75 APE8-rot-na 27.6 APE67-dihe-in -61.51, -22.54 -51.34, -46.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.599 0.179 0.202 A 361 266 21 0 0 21 [[621, 880]] 1.0 4p4c TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
3DZQA 609 904 983.0 IFC:1001 Type2 Inactive DFGout 12.188 10.519 BBAminus -129.57, -168.19 -165.15, 114.41 -97.71, 3.93 310.73, 122.64 77.89, 179.81 in-in in 8.723 Saltbr-in 2.887 HRD-in -69.82, -48.35 78.08, -13.1 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.74 APE8-rot-na 32.01 APE67-dihe-in -59.74, -24.27 -53.21, -45.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.163 0.193 A 361 268 19 0 0 19 [[621, 880]] 1.0 3dzq TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4P5ZA 609 903 983.0 Q7M:1001 Type2 Inactive DFGout 13.292 10.879 None -140.44, 179.96 -154.78, 121.55 -93.32, 999.0 304.13, 2.84 999.0, 999.0 in-in in 8.393 Saltbr-in 2.404 HRD-in -71.57, -48.07 73.69, -12.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.99 APE8-rot-na 25.37 APE67-dihe-in -70.7, -19.96 -54.73, -39.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.002 0.18 0.218 A 361 267 21 0 0 21 [[621, 880]] 1.0 4p5z TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4TWNA 609 904 983.0 B96:61001 Type2 Inactive DFGout 14.986 9.573 None -134.69, 178.86 -131.05, 59.68 -53.31, -39.8 189.13, 20.76 -55.32, -51.3 in-in in 7.888 Saltbr-in 2.742 HRD-in -68.13, -51.37 74.28, -15.64 in-out-none SNCion out-none ActLoopNT-out 15.4 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 144.68 APE9-dihe-in -85.61, 124.0 APE8-dihe-in -68.13, 87.14 APE8-rot-na 27.02 APE67-dihe-in -60.95, -25.35 -49.7, -47.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.951 APE9-dist-in 6.704 None None None XRAY 1.706 0.179 0.213 A 361 275 15 0 0 15 [[621, 880]] 1.0 4twn TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOQA 595 906 983.0 ANP:948 ATPlike None DFGin 5.36 15.575 BLAminus -132.4, -170.9 64.35, 72.55 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.635 Saltbr-in 2.727 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.743 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373 285 18 0 0 18 [[621, 880]] 1.0 2qoq TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2GSFA 595 904 983.0 No_ligand No_ligand None DFGin 5.349 15.927 BLAminus -131.51, -172.61 60.33, 76.56 -88.59, 16.43 293.13, 100.05 -68.35, -25.64 in-in in 8.866 Saltbr-in 2.652 HRD-in -71.12, -50.16 76.26, -12.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.12 APE8-rot-na 32.33 APE67-dihe-in -59.76, -26.04 -51.66, -46.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 A608T None None XRAY 1.77 0.16 0.195 A 373 281 16 0 0 16 [[621, 880]] 1.0 2gsf TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
2QOKA 595 904 983.0 No_ligand No_ligand None DFGin 5.347 15.982 BLAminus -129.42, -174.51 59.36, 78.84 -100.22, 55.36 291.83, 96.7 -103.96, -34.04 in-in in 8.81 Saltbr-in 2.76 HRD-in -71.78, -47.74 73.73, -11.15 in-in-none SNCiin in-none ActLoopNT-in 3.035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 55.48 APE8-dihe-in -87.96, 87.99 APE8-rot-na 33.99 APE67-dihe-in -60.98, -24.84 -56.01, -43.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.629 Y596F,Y602F,S768A None None XRAY 1.2 0.192 0.212 A 373 281 15 0 0 15 [[621, 880]] 1.0 2qok TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4GK3A 609 903 983.0 L87:1001 Type1 None DFGin 5.139 14.807 BLAminus -128.6, -167.12 48.3, 97.81 -109.44, 24.03 294.5, 89.74 -59.07, -35.31 in-in in 8.501 Saltbr-in 2.722 HRD-in -73.64, -49.53 73.8, -7.65 in-in-none SNCiin in-none ActLoopNT-in 3.009 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.11 APE8-dihe-in -78.03, 100.04 APE8-rot-na 30.24 APE67-dihe-in -60.07, -23.79 -51.41, -46.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.718 None None None XRAY 1.898 0.18 0.213 A 361 275 14 0 0 14 [[621, 880]] 1.0 4gk3 TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4P5QA 609 904 983.0 Q0B:1001 Type1 None DFGin 5.364 15.215 BLAminus -132.21, -177.08 65.28, 76.17 -99.61, 30.73 291.45, 96.46 -83.91, -18.12 in-in in 8.287 Saltbr-in 3.266 HRD-in -71.43, -46.81 71.58, -8.33 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.01 APE8-dihe-in -79.2, 95.75 APE8-rot-na 30.23 APE67-dihe-in -60.52, -25.3 -53.27, -46.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.974 None None None XRAY 1.35 0.158 0.182 A 361 275 16 0 0 16 [[621, 880]] 1.0 4p5q TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4TWOA 609 906 983.0 37W:1001 Type1 None DFGin 5.261 14.863 BLAminus -137.23, -171.69 56.38, 84.7 -101.99, 32.13 298.62, 95.53 -60.78, -52.61 in-in in 8.171 Saltbr-in 3.147 HRD-in -68.52, -51.72 76.5, -11.58 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 87.71 APE8-rot-na 30.54 APE67-dihe-in -57.89, -27.69 -50.33, -47.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.047 0.165 0.201 A 361 278 15 0 0 15 [[621, 880]] 1.0 4two TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4G2FA 609 903 983.0 C07:1001 Type1.5_Back None DFGin 5.45 14.73 BLAminus -131.64, -174.37 59.7, 79.41 -98.99, 31.81 296.97, 96.01 -73.91, -33.0 in-in in 8.217 Saltbr-in 2.799 HRD-in -73.48, -46.44 72.16, -6.7 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 96.83 APE8-rot-na 28.88 APE67-dihe-in -63.99, -23.43 -56.19, -41.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.699 0.18 0.208 A 361 275 15 0 0 15 [[621, 880]] 1.0 4g2f TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4GK2A 609 903 983.0 L66:1001 Type1.5_Back None DFGin 5.393 14.345 BLAminus -141.54, -172.14 65.23, 79.03 -100.69, 30.27 304.12, 98.46 -69.06, -39.74 in-in in 7.956 Saltbr-in 2.511 HRD-in -70.13, -49.29 72.76, -10.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.91 APE8-rot-na 28.95 APE67-dihe-in -60.83, -25.11 -56.53, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.195 0.193 0.236 A 361 265 19 0 0 19 [[621, 880]] 1.0 4gk2 TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
4GK4A 609 903 983.0 L90:1001 Type1.5_Back None DFGin 5.006 14.462 BLAminus -141.92, -169.06 54.42, 84.57 -99.59, 22.26 304.42, 95.75 -54.8, -38.22 in-in in 8.552 Saltbr-in 3.151 HRD-in -68.01, -52.25 74.92, -3.22 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -110.32 APE9-dihe-in -98.4, 140.84 APE8-dihe-in -76.92, 99.05 APE8-rot-na 30.32 APE67-dihe-in -60.09, -27.75 -52.08, -44.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.922 APE9-dist-in 5.745 None None None XRAY 2.1 0.176 0.226 A 361 275 13 0 0 13 [[621, 880]] 1.0 4gk4 TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3

TYR_EPHA3 (Ephrin type-A receptor 3)

Total number of chains: 29
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 69.0% AF-P29320-K1A
DFGin None 6 20.7% 2QODA
DFGout None 2 6.9% 4TWNA
DFGout BBAminus 1 3.4% 3DZQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA3_HUMAN AF-P29320-K1A P29320 613 888 983.0 No_ligand No_ligand Active DFGin 5.965 14.207 BLAminus -140.17, 176.14 64.75, 67.74 -84.89, 12.18 298.41, 93.53 -59.25, -34.26 in-in in 8.104 Saltbr-in 2.716 HRD-in -76.92, -44.9 68.93, -11.94 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.71, 137.86 APE9-dihe-in -117.09, 122.76 APE8-dihe-in -75.6, 83.17 APE8-rot-na 33.33 APE67-dihe-in -68.16, -18.52 -43.46, -48.96 APE12-dist-na 11.002 APE11-dist-na 8.699 APE10-dist-na 9.461 APE9-dist-in 6.179 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[621, 880]] 1.0 AF-P29320-K1 Homo sapiens TYR_EPHA3_HUMAN TYR 3.9e-111 376.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN AF-P29320-K3A P29320 613 888 983.0 No_ligand No_ligand Active DFGin 5.996 14.445 BLAminus -143.09, -179.44 62.4, 65.79 -80.18, 9.38 292.91, 97.16 -59.5, -31.3 in-in in 8.069 Saltbr-in 2.678 HRD-in -79.18, -46.7 71.28, -7.59 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.11, 145.03 APE9-dihe-in -123.06, 131.23 APE8-dihe-in -76.8, 78.27 APE8-rot-na 34.09 APE67-dihe-in -65.23, -16.26 -42.71, -48.59 APE12-dist-na 11.534 APE11-dist-na 9.196 APE10-dist-na 9.937 APE9-dist-in 6.324 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[621, 880]] 1.0 AF-P29320-K3 Homo sapiens TYR_EPHA3_HUMAN TYR 3.9e-111 376.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOCA P29320 613 906 983.0 ANP:949 ATPlike Inactive DFGin 4.995 15.445 BLAminus -141.69, -171.73 58.63, 84.29 -97.26, 21.84 297.12, 103.61 -61.69, -31.71 in-out in 9.495 Saltbr-out 6.048 HRD-in -71.05, -48.03 74.01, -8.74 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 135.66 APE9-dihe-in -81.0, 137.87 APE8-dihe-in -77.44, 99.9 APE8-rot-na 34.81 APE67-dihe-in -63.09, -22.76 -54.0, -44.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.214 APE9-dist-in 5.514 None None None XRAY 1.25 0.17 0.186 A 344 283 11 0 0 11 [[621, 880]] 1.0 2qoc Homo sapiens TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 3FXXA P29320 606 904 983.0 ANP:992 ATPlike Inactive DFGin 4.9 15.171 BLAminus -132.57, -176.13 56.24, 78.37 -91.43, 22.66 298.54, 96.01 -59.15, -30.35 in-out in 9.376 Saltbr-out 4.254 HRD-in -72.67, -46.91 76.32, -4.64 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.39, 147.18 APE9-dihe-in -116.01, 151.61 APE8-dihe-in -77.44, 77.25 APE8-rot-na 30.85 APE67-dihe-in -60.25, -20.23 -50.19, -49.06 APE12-dist-na 999.0 APE11-dist-na 8.999 APE10-dist-na 10.183 APE9-dist-in 6.238 A608T None None XRAY 1.7 0.168 0.194 A 371 288 9 0 0 9 [[621, 880]] 1.0 3fxx Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QO7A P29320 595 904 983.0 ANP:1000 ATPlike Inactive DFGin 5.481 15.556 BLAminus -130.76, -168.32 68.6, 58.57 -92.37, 46.9 297.61, 96.94 -87.84, 999.0 in-out in 8.4 Saltbr-out 4.348 HRD-in -73.41, -45.48 73.79, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.99 APE8-rot-na 29.77 APE67-dihe-in -61.7, -25.84 -53.26, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR701 PTR701 XRAY 1.605 0.186 0.224 A 373 279 20 0 0 20 [[621, 880]] 1.0 2qo7 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QO9A P29320 608 904 983.0 ANP:948 ATPlike Inactive DFGin 5.205 15.375 BLAminus -133.34, -177.89 59.05, 80.14 -92.65, 15.74 295.85, 100.25 -55.83, -40.55 in-out in 9.235 Saltbr-out 4.23 HRD-in -71.62, -45.86 73.18, -10.67 out-in-out SNCoio in-out ActLoopNT-in 2.997 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 105.46 APE9-dihe-out 41.85, 78.2 APE8-dihe-in -71.02, 94.17 APE8-rot-na 29.94 APE67-dihe-in -61.69, -23.23 -54.76, -43.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.168 APE9-dist-in 5.854 None None None XRAY 1.55 0.183 0.211 A 373 277 13 0 0 13 [[621, 880]] 1.0 2qo9 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOBA P29320 609 906 983.0 No_ligand No_ligand Inactive DFGin 5.066 14.928 BLAminus -139.34, -172.16 58.85, 83.97 -96.38, 20.44 301.06, 100.21 -60.34, -35.17 in-out in 8.954 Saltbr-out 4.319 HRD-in -74.47, -48.3 72.91, -7.69 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -49.79 APE9-dihe-in -72.25, 128.89 APE8-dihe-in -78.68, 90.62 APE8-rot-na 31.34 APE67-dihe-in -62.26, -23.36 -52.95, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.098 APE9-dist-in 5.953 None PTR701 PTR701 XRAY 1.65 0.17 0.196 A 344 281 13 0 0 13 [[621, 880]] 1.0 2qob Homo sapiens TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 3FY2A P29320 607 904 983.0 No_ligand No_ligand Inactive DFGin 5.001 15.145 BLAminus -134.96, -176.32 58.57, 75.9 -90.06, 19.9 298.27, 99.27 -58.2, -34.52 in-out in 9.255 Saltbr-out 3.762 HRD-in -69.79, -49.72 73.39, -4.5 out-in-in SNCoii in-in ActLoopNT-in 2.995 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.03, 136.16 APE9-dihe-in -109.97, 152.44 APE8-dihe-in -78.29, 81.42 APE8-rot-na 30.96 APE67-dihe-in -61.02, -19.58 -53.79, -46.87 APE12-dist-na 999.0 APE11-dist-na 9.092 APE10-dist-na 10.203 APE9-dist-in 6.346 A608T None None XRAY 1.8 0.181 0.212 A 371 285 10 0 0 10 [[621, 880]] 1.0 3fy2 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QO2A P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.584 16.12 BLAminus -131.8, -165.29 66.45, 65.03 -102.63, 10.59 295.47, 102.56 -82.74, 999.0 in-in in 8.355 Saltbr-in 2.694 HRD-in -72.66, -47.05 74.97, -15.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.34 APE8-rot-na 320.93 APE67-dihe-out -61.72, -23.71 166.11, -52.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.177 0.203 A 373 282 20 0 0 20 [[621, 880]] 1.0 2qo2 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QONA P29320 595 905 983.0 No_ligand No_ligand Inactive DFGin 5.067 15.854 BLAminus -131.83, 179.54 60.62, 74.52 -94.47, 24.38 299.54, 95.48 -58.75, -38.51 in-out in 9.296 Saltbr-out 4.112 HRD-in -72.22, -48.07 71.7, -10.11 out-in-none SNCoin in-none ActLoopNT-in 2.853 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.56 APE8-dihe-in -66.11, 89.51 APE8-rot-na 28.14 APE67-dihe-in -62.78, -22.64 -52.51, -42.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.262 Y596F,Y602F,Y742A PTR701 PTR701 XRAY 1.79 0.175 0.191 A 373 282 16 0 0 16 [[621, 880]] 1.0 2qon Homo sapiens TYR_EPHA3_HUMAN TYR 4.8e-110 372.9 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 6IN0A P29320 613 903 983.0 O4B:1003,O4B:1004 Type3,Allosteric Inactive DFGin 4.986 15.861 BLAminus -133.21, -172.75 59.01, 74.39 -87.51, 7.85 292.48, 90.28 -50.7, -40.3 in-out in 9.579 Saltbr-out 4.943 HRD-in -74.58, -48.98 74.89, -18.28 out-in-none SNCoin in-none ActLoopNT-in 2.955 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.77 APE8-dihe-in -75.79, 85.61 APE8-rot-na 30.12 APE67-dihe-in -60.41, -27.1 -48.99, -47.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.242 None None None XRAY 1.501 0.197 0.229 A 301 272 14 0 0 14 [[621, 880]] 1.0 6in0 Homo sapiens TYR_EPHA3_HUMAN TYR 5.3e-111 376.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOOA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.57 16.139 None -130.25, -171.33 69.56, 59.1 -97.35, 999.0 296.3, 100.28 999.0, 999.0 in-in in 8.844 Saltbr-in 2.167 HRD-in -71.72, -46.92 71.95, -7.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -147.9 APE8-rot-na 327.21 APE67-dihe-in -60.63, -26.51 -52.34, -45.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,Y742F None None XRAY 1.25 0.19 0.202 A 373 273 21 0 0 21 [[621, 880]] 1.0 2qoo Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOFA P29320 595 906 983.0 No_ligand No_ligand Inactive DFGin 5.574 16.154 None -128.85, -171.0 68.65, 68.64 -106.11, 999.0 294.29, 100.28 999.0, 999.0 in-in in 8.483 Saltbr-in 2.866 HRD-in -71.61, -47.44 75.56, -15.18 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.26 APE8-rot-na 32.87 APE67-dihe-in -60.72, -24.96 -52.12, -45.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F None None XRAY 1.2 0.182 0.195 A 373 280 21 0 0 21 [[621, 880]] 1.0 2qof Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QODA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.547 16.055 None -131.77, -171.54 68.49, 69.41 -105.64, 999.0 292.55, 100.77 999.0, 999.0 in-in in 8.459 Saltbr-in 2.977 HRD-in -71.92, -47.0 75.02, -14.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.55 APE8-rot-na 32.64 APE67-dihe-in -61.1, -23.78 -54.99, -44.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y602F None None XRAY 1.15 0.193 0.206 A 373 274 21 0 0 21 [[621, 880]] 1.0 2qod Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOIA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.619 16.256 None -129.96, -173.84 70.71, 70.9 -110.19, 999.0 293.26, 97.85 999.0, 999.0 in-in in 8.916 Saltbr-in 2.155 HRD-in -70.57, -48.64 76.1, -13.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.52 APE8-rot-na 29.06 APE67-dihe-in -60.23, -25.5 -51.78, -44.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.25 0.186 0.192 A 373 274 21 0 0 21 [[621, 880]] 1.0 2qoi Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOLA P29320 595 904 983.0 No_ligand No_ligand Inactive DFGin 5.53 15.953 None -127.91, -172.59 67.31, 78.66 -111.91, 999.0 291.32, 93.34 999.0, 999.0 in-in in 8.426 Saltbr-in 3.115 HRD-in -70.18, -47.4 74.82, -14.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -61.36, -24.47 999.0, -38.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F,S768G None None XRAY 1.07 0.196 0.211 A 373 273 22 0 0 22 [[621, 880]] 1.0 2qol Homo sapiens TYR_EPHA3_HUMAN TYR 3.8e-110 373.3 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4P4CA P29320 613 904 983.0 25Q:1001 Type1 Inactive DFGin 5.482 15.719 None -128.35, -167.77 63.56, 68.23 -102.55, 999.0 294.45, 99.08 999.0, 999.0 in-in in 8.262 Saltbr-in 2.859 HRD-in -69.2, -49.45 78.06, -9.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.75 APE8-rot-na 27.6 APE67-dihe-in -61.51, -22.54 -51.34, -46.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.599 0.179 0.202 A 361 266 21 0 0 21 [[621, 880]] 1.0 4p4c Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 3DZQA P29320 609 904 983.0 IFC:1001 Type2 Inactive DFGout 12.188 10.519 BBAminus -129.57, -168.19 -165.15, 114.41 -97.71, 3.93 310.73, 122.64 77.89, 179.81 in-in in 8.723 Saltbr-in 2.887 HRD-in -69.82, -48.35 78.08, -13.1 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.74 APE8-rot-na 32.01 APE67-dihe-in -59.74, -24.27 -53.21, -45.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.163 0.193 A 361 268 19 0 0 19 [[621, 880]] 1.0 3dzq Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4P5ZA P29320 609 903 983.0 Q7M:1001 Type2 Inactive DFGout 13.292 10.879 None -140.44, 179.96 -154.78, 121.55 -93.32, 999.0 304.13, 2.84 999.0, 999.0 in-in in 8.393 Saltbr-in 2.404 HRD-in -71.57, -48.07 73.69, -12.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.99 APE8-rot-na 25.37 APE67-dihe-in -70.7, -19.96 -54.73, -39.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.002 0.18 0.218 A 361 267 21 0 0 21 [[621, 880]] 1.0 4p5z Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4TWNA P29320 609 904 983.0 B96:61001 Type2 Inactive DFGout 14.986 9.573 None -134.69, 178.86 -131.05, 59.68 -53.31, -39.8 189.13, 20.76 -55.32, -51.3 in-in in 7.888 Saltbr-in 2.742 HRD-in -68.13, -51.37 74.28, -15.64 in-out-none SNCion out-none ActLoopNT-out 15.4 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 144.68 APE9-dihe-in -85.61, 124.0 APE8-dihe-in -68.13, 87.14 APE8-rot-na 27.02 APE67-dihe-in -60.95, -25.35 -49.7, -47.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.951 APE9-dist-in 6.704 None None None XRAY 1.706 0.179 0.213 A 361 275 15 0 0 15 [[621, 880]] 1.0 4twn Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.36 15.575 BLAminus -132.4, -170.9 64.35, 72.55 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.635 Saltbr-in 2.727 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.743 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373 285 18 0 0 18 [[621, 880]] 1.0 2qoq Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2GSFA P29320 595 904 983.0 No_ligand No_ligand None DFGin 5.349 15.927 BLAminus -131.51, -172.61 60.33, 76.56 -88.59, 16.43 293.13, 100.05 -68.35, -25.64 in-in in 8.866 Saltbr-in 2.652 HRD-in -71.12, -50.16 76.26, -12.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.12 APE8-rot-na 32.33 APE67-dihe-in -59.76, -26.04 -51.66, -46.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 A608T None None XRAY 1.77 0.16 0.195 A 373 281 16 0 0 16 [[621, 880]] 1.0 2gsf Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 2QOKA P29320 595 904 983.0 No_ligand No_ligand None DFGin 5.347 15.982 BLAminus -129.42, -174.51 59.36, 78.84 -100.22, 55.36 291.83, 96.7 -103.96, -34.04 in-in in 8.81 Saltbr-in 2.76 HRD-in -71.78, -47.74 73.73, -11.15 in-in-none SNCiin in-none ActLoopNT-in 3.035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 55.48 APE8-dihe-in -87.96, 87.99 APE8-rot-na 33.99 APE67-dihe-in -60.98, -24.84 -56.01, -43.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.629 Y596F,Y602F,S768A None None XRAY 1.2 0.192 0.212 A 373 281 15 0 0 15 [[621, 880]] 1.0 2qok Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4GK3A P29320 609 903 983.0 L87:1001 Type1 None DFGin 5.139 14.807 BLAminus -128.6, -167.12 48.3, 97.81 -109.44, 24.03 294.5, 89.74 -59.07, -35.31 in-in in 8.501 Saltbr-in 2.722 HRD-in -73.64, -49.53 73.8, -7.65 in-in-none SNCiin in-none ActLoopNT-in 3.009 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.11 APE8-dihe-in -78.03, 100.04 APE8-rot-na 30.24 APE67-dihe-in -60.07, -23.79 -51.41, -46.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.718 None None None XRAY 1.898 0.18 0.213 A 361 275 14 0 0 14 [[621, 880]] 1.0 4gk3 Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4P5QA P29320 609 904 983.0 Q0B:1001 Type1 None DFGin 5.364 15.215 BLAminus -132.21, -177.08 65.28, 76.17 -99.61, 30.73 291.45, 96.46 -83.91, -18.12 in-in in 8.287 Saltbr-in 3.266 HRD-in -71.43, -46.81 71.58, -8.33 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.01 APE8-dihe-in -79.2, 95.75 APE8-rot-na 30.23 APE67-dihe-in -60.52, -25.3 -53.27, -46.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.974 None None None XRAY 1.35 0.158 0.182 A 361 275 16 0 0 16 [[621, 880]] 1.0 4p5q Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4TWOA P29320 609 906 983.0 37W:1001 Type1 None DFGin 5.261 14.863 BLAminus -137.23, -171.69 56.38, 84.7 -101.99, 32.13 298.62, 95.53 -60.78, -52.61 in-in in 8.171 Saltbr-in 3.147 HRD-in -68.52, -51.72 76.5, -11.58 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 87.71 APE8-rot-na 30.54 APE67-dihe-in -57.89, -27.69 -50.33, -47.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.047 0.165 0.201 A 361 278 15 0 0 15 [[621, 880]] 1.0 4two Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4G2FA P29320 609 903 983.0 C07:1001 Type1.5_Back None DFGin 5.45 14.73 BLAminus -131.64, -174.37 59.7, 79.41 -98.99, 31.81 296.97, 96.01 -73.91, -33.0 in-in in 8.217 Saltbr-in 2.799 HRD-in -73.48, -46.44 72.16, -6.7 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 96.83 APE8-rot-na 28.88 APE67-dihe-in -63.99, -23.43 -56.19, -41.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.699 0.18 0.208 A 361 275 15 0 0 15 [[621, 880]] 1.0 4g2f Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4GK2A P29320 609 903 983.0 L66:1001 Type1.5_Back None DFGin 5.393 14.345 BLAminus -141.54, -172.14 65.23, 79.03 -100.69, 30.27 304.12, 98.46 -69.06, -39.74 in-in in 7.956 Saltbr-in 2.511 HRD-in -70.13, -49.29 72.76, -10.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.91 APE8-rot-na 28.95 APE67-dihe-in -60.83, -25.11 -56.53, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.195 0.193 0.236 A 361 265 19 0 0 19 [[621, 880]] 1.0 4gk2 Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
EPHA3_HUMAN 4GK4A P29320 609 903 983.0 L90:1001 Type1.5_Back None DFGin 5.006 14.462 BLAminus -141.92, -169.06 54.42, 84.57 -99.59, 22.26 304.42, 95.75 -54.8, -38.22 in-in in 8.552 Saltbr-in 3.151 HRD-in -68.01, -52.25 74.92, -3.22 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -110.32 APE9-dihe-in -98.4, 140.84 APE8-dihe-in -76.92, 99.05 APE8-rot-na 30.32 APE67-dihe-in -60.09, -27.75 -52.08, -44.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.922 APE9-dist-in 5.745 None None None XRAY 2.1 0.176 0.226 A 361 275 13 0 0 13 [[621, 880]] 1.0 4gk4 Homo sapiens TYR_EPHA3_HUMAN TYR 9.8e-111 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3

TYR_EPHA3 (Ephrin type-A receptor 3)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name