AGC_AKT1 (RAC-alpha serine/threonine-protein kinase)

Total number of chains: 39
Active chains: 21
Uniprot: AKT1_HUMAN
Kinase Domain Residues: 150 - 408
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 56.4% AF-P31749-K1A
DFGout BBAminus 9 23.1% 6HHJA
None None 6 15.4% 6HHIA
DFGout None 2 5.1% 5KCVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
4EKKA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
4EKKB 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
AF-P31749-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 142 - 416 0 None None RAC-alpha serine/threonine-protein kinase
AF-P31749-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 142 - 416 0 None None RAC-alpha serine/threonine-protein kinase
6BUUA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 478 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase
6BUUB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 477 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase
6NPZA 2.12 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 142 - 478 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase
6NPZB 2.12 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 141 - 477 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase
4GV1A 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 0XZ Type1 144 - 477 0 TPO308 None RAC-alpha serine/threonine-protein kinase
3OCBA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XM1 Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3OCBB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XM1 Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3OW4A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMY Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3OW4B 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMY Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3QKLA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMR Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3QKMA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SM9 Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
4EKLA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 0RF Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3CQWA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CQW Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3MV5A 2.47 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XFE Type1 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3MVHA 2.01 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii WFE Type1 145 - 476 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
6CCYA 2.18 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX4 Type1 144 - 983 0 TPO308 N199S,S396P,E397S,T433V RAC-alpha serine/threonine-protein kinase
3QKKA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMH Type1.5_Front 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
3CQUA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CQU Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
8UVYA 2.11 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XOO Allosteric 3 - 439 0 None E17K RAC-alpha serine/threonine-protein kinase
8UW2A 2.2 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaioi APEdist_oooo XOO Allosteric 4 - 437 0 None None RAC-alpha serine/threonine-protein kinase
8UW9A 1.9 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XQ2 Allosteric 3 - 428 0 None None RAC-alpha serine/threonine-protein kinase
8UW7A 1.972 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 439 0 None None RAC-alpha serine/threonine-protein kinase
3O96A 2.7 Inactive DFGout‑BBAminus none-none out-none nonTYR APEdihe_aannn APEdist_nnnn IQO Allosteric 2 - 429 0 None None RAC-alpha serine/threonine-protein kinase
6HHHA 2.7 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaooi APEdist_nnno G4Q Allosteric 2 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
6HHJA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo G4H Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
6S9WA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo L1Z Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
4EJNA 2.19 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_oioo 0R4 Type1 4 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
5KCVA 2.7 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn 6S1 Allosteric 6 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
7APJA 2.05 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 3 - 439 0 None S2N RAC-alpha serine/threonine-protein kinase
6HHFA 2.9 Inactive None‑None none-none out-out nonTYR APEdihe_aanoi APEdist_nnnn G4K Allosteric 3 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
6HHGA 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4T Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
6HHIA 2.7 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4N Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
6S9XA 2.6 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo L1W Allosteric 3 - 443 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
7NH4A 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo UCE Allosteric 4 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
7NH5A 1.9 Inactive None‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo UC8 Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase

AGC_AKT1 (RAC-alpha serine/threonine-protein kinase)

Total number of chains: 39
Active chains: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 56.4% AF-P31749-K1A
DFGout BBAminus 9 23.1% 6HHJA
None None 6 15.4% 6HHIA
DFGout None 2 5.1% 5KCVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AKT1_HUMAN 4EKKA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 4EKKB 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN AF-P31749-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 142 - 416 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN AF-P31749-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 142 - 416 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6BUUA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 478 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6BUUB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 144 - 477 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6NPZA 2.12 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 142 - 478 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6NPZB 2.12 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 141 - 477 0 TPO308,SEP473,SEP477 None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 4GV1A 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 0XZ Type1 144 - 477 0 TPO308 None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3OCBA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XM1 Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3OCBB 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XM1 Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3OW4A 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMY Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3OW4B 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMY Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3QKLA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMR Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3QKMA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SM9 Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 4EKLA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 0RF Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3CQWA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii CQW Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3MV5A 2.47 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XFE Type1 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3MVHA 2.01 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii WFE Type1 145 - 476 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6CCYA 2.18 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX4 Type1 144 - 983 0 TPO308 N199S,S396P,E397S,T433V RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3QKKA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SMH Type1.5_Front 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3CQUA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii CQU Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 8UVYA 2.11 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XOO Allosteric 3 - 439 0 None E17K RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 8UW2A 2.2 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaioi APEdist_oooo XOO Allosteric 4 - 437 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 8UW9A 1.9 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_iiio XQ2 Allosteric 3 - 428 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 8UW7A 1.972 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno XOO Allosteric 3 - 439 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 3O96A 2.7 Inactive DFGout‑BBAminus none-none out-none nonTYR APEdihe_aannn APEdist_nnnn IQO Allosteric 2 - 429 0 None None RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6HHHA 2.7 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaooi APEdist_nnno G4Q Allosteric 2 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6HHJA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo G4H Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6S9WA 2.3 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo L1Z Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 4EJNA 2.19 Inactive DFGout‑BBAminus none-none out-out nonTYR APEdihe_aaiii APEdist_oioo 0R4 Type1 4 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 5KCVA 2.7 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn 6S1 Allosteric 6 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 7APJA 2.05 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 3 - 439 0 None S2N RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6HHFA 2.9 Inactive None‑None none-none out-out nonTYR APEdihe_aanoi APEdist_nnnn G4K Allosteric 3 - 439 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6HHGA 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4T Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6HHIA 2.7 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo G4N Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 6S9XA 2.6 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo L1W Allosteric 3 - 443 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 7NH4A 2.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo UCE Allosteric 4 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AKT1_HUMAN 7NH5A 1.9 Inactive None‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo UC8 Allosteric 3 - 444 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens

AGC_AKT1 (RAC-alpha serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism