AGC_AKT1 (RAC-alpha serine/threonine-protein kinase)

Total number of chains: 39
Active chains: 21
Uniprot: AKT1_HUMAN
Kinase Domain Residues: 150 - 408
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 56.4% AF-P31749-K1A
DFGout BBAminus 9 23.1% 6HHJA
None None 6 15.4% 6HHIA
DFGout None 2 5.1% 5KCVA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AKT1 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0476 13.1126 BLAminus -112.5, -177.27 66.46, 90.66 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.6509 Saltbr-in 2.9785 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.0497 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.8136 APE11-dist-in 11.7177 APE10-dist-in 6.0702 APE9-dist-in 4.0693 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0752 13.0461 BLAminus -112.98, 175.61 60.18, 117.01 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.7662 Saltbr-in 2.6652 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.7699 APE11-dist-in 11.6858 APE10-dist-in 6.1252 APE9-dist-in 4.2849 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AF-P31749-K1A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 6.2627 13.1451 BLAminus -114.62, -167.38 40.57, 67.78 -78.23, 20.61 301.26, 84.0 -56.98, -40.88 in-in in 8.6803 Saltbr-in 2.6805 HRD-in -78.93, -42.17 64.1, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.8678 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.25, 159.39 APE9-dihe-na 136.34, -176.15 APE8-dihe-in -90.74, 129.43 APE8-rot-in 299.37 APE67-dihe-in -70.7, -14.81 -47.91, -45.56 APE12-dist-in 8.3219 APE11-dist-in 11.7485 APE10-dist-in 6.046 APE9-dist-in 3.7787 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[150, 408]] 1.0 AF-P31749-K1 AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AF-P31749-K3A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 5.8611 13.3307 BLAminus -119.71, -175.9 43.31, 87.62 -90.32, 18.66 297.34, 81.96 -61.74, -29.8 in-in in 8.7895 Saltbr-in 2.6984 HRD-in -81.85, -49.76 69.24, 0.24 in-in-in SNCiii in-in ActLoopNT-in 2.8866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.64, 153.01 APE9-dihe-na 135.73, 179.27 APE8-dihe-in -81.81, 130.02 APE8-rot-in 289.58 APE67-dihe-in -69.79, -14.8 -47.58, -43.93 APE12-dist-in 8.4868 APE11-dist-in 11.4734 APE10-dist-in 5.8661 APE9-dist-in 4.2622 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[150, 408]] 1.0 AF-P31749-K3 AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6BUUA P31749 144 478 480.0 No_ligand No_ligand Active DFGin 6.4595 13.5609 BLAminus -129.81, 166.71 63.43, 103.36 -112.37, 8.26 300.4, 87.1 -62.82, -21.63 in-in in 8.5651 Saltbr-in 3.3205 HRD-in -78.21, -43.42 65.34, -10.93 in-in-in SNCiii in-in ActLoopNT-in 2.7848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.8, 159.61 APE9-dihe-na 139.87, -147.27 APE8-dihe-in -120.07, 129.86 APE8-rot-in 299.9 APE67-dihe-in -65.46, -21.29 -53.54, -42.3 APE12-dist-in 8.7204 APE11-dist-in 11.7316 APE10-dist-in 6.2384 APE9-dist-in 4.0846 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.4 0.185 0.23 A 337.0 323.0 0 28 28 0 [[150, 408]] 1.0 6buu AGC_AKT1_HUMAN AGC 2.2e-99 337.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6BUUB P31749 144 477 480.0 No_ligand No_ligand Active DFGin 6.4216 13.4748 BLAminus -128.87, 158.63 82.78, 97.45 -111.26, 12.46 302.86, 92.31 -62.01, -29.27 in-in in 8.6218 Saltbr-in 2.6118 HRD-in -74.01, -46.33 68.16, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.9455 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.84, 167.54 APE9-dihe-na 132.85, -158.22 APE8-dihe-in -118.97, 130.29 APE8-rot-in 299.43 APE67-dihe-in -70.47, -18.64 -52.17, -43.37 APE12-dist-in 8.7996 APE11-dist-in 11.7592 APE10-dist-in 6.0782 APE9-dist-in 3.9353 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.4 0.185 0.23 B 337.0 319.0 0 28 28 0 [[150, 408]] 1.0 6buu AGC_AKT1_HUMAN AGC 2.2e-99 337.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6NPZA P31749 142 478 480.0 No_ligand No_ligand Active DFGin 6.2434 13.5168 BLAminus -119.48, 178.99 63.44, 89.04 -107.85, 9.08 296.64, 94.01 -63.0, -21.88 in-in in 8.9042 Saltbr-in 3.0045 HRD-in -76.14, -48.91 69.19, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.9946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.99, 160.01 APE9-dihe-na 134.89, -153.13 APE8-dihe-in -119.22, 128.69 APE8-rot-in 299.44 APE67-dihe-in -61.81, -21.05 -49.68, -44.36 APE12-dist-in 8.2833 APE11-dist-in 11.5575 APE10-dist-in 5.9575 APE9-dist-in 3.903 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.12 0.188 0.241 A 358.0 322.0 0 28 28 0 [[150, 408]] 1.0 6npz AGC_AKT1_HUMAN AGC 2.7e-99 337.5 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6NPZB P31749 141 477 480.0 No_ligand No_ligand Active DFGin 6.4917 13.7105 BLAminus -117.03, 171.77 71.96, 91.9 -107.91, 11.41 295.22, 94.23 -65.12, -23.31 in-in in 8.8064 Saltbr-in 3.0893 HRD-in -77.35, -47.58 69.03, -7.27 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.06, 158.85 APE9-dihe-na 134.94, -150.01 APE8-dihe-in -122.61, 125.21 APE8-rot-in 296.0 APE67-dihe-in -68.07, -17.45 -48.75, -43.62 APE12-dist-in 8.4844 APE11-dist-in 11.6913 APE10-dist-in 6.0438 APE9-dist-in 3.8563 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.12 0.188 0.241 B 358.0 323.0 0 28 28 0 [[150, 408]] 1.0 6npz AGC_AKT1_HUMAN AGC 2.7e-99 337.5 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 4GV1A P31749 144 477 480.0 0XZ:60501 Type1 Active DFGin 6.4884 13.5625 BLAminus -122.36, 161.99 68.48, 91.61 -104.89, 11.22 297.02, 96.69 -63.45, -24.57 in-in in 8.8168 Saltbr-in 2.4724 HRD-in -73.6, -46.3 69.86, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.52, 165.79 APE9-dihe-na 129.18, -173.05 APE8-dihe-in -103.26, 131.39 APE8-rot-in 301.03 APE67-dihe-in -66.34, -18.55 -46.14, -49.45 APE12-dist-in 8.4811 APE11-dist-in 11.5527 APE10-dist-in 5.9982 APE9-dist-in 4.0985 None TPO308 TPO308 XRAY 1.49 0.182 0.21 A 340.0 329.0 0 28 28 0 [[150, 408]] 1.0 4gv1 AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3OCBA P31749 144 478 480.0 XM1:1 Type1 Active DFGin 6.6382 13.8031 BLAminus -116.95, 176.33 66.85, 80.21 -101.71, 15.06 291.18, 80.12 -62.95, -27.15 in-in in 8.7712 Saltbr-in 2.7698 HRD-in -68.69, -47.69 74.78, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.9855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.18, 163.1 APE9-dihe-na 135.15, -135.96 APE8-dihe-in -136.2, 122.51 APE8-rot-in 298.45 APE67-dihe-in -66.42, -19.48 -44.24, -42.98 APE12-dist-in 8.435 APE11-dist-in 11.4893 APE10-dist-in 5.8878 APE9-dist-in 4.0576 S473D TPO308 TPO308 XRAY 2.7 0.217 0.282 A 341.0 316.0 0 28 28 0 [[150, 408]] 1.0 3ocb AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3OCBB P31749 144 478 480.0 XM1:2 Type1 Active DFGin 6.3319 13.3989 BLAminus -134.12, 162.45 65.57, 102.27 -117.67, 11.66 296.51, 86.34 -58.99, -28.22 in-in in 8.8145 Saltbr-in 2.8714 HRD-in -68.9, -44.89 75.11, -22.64 in-in-in SNCiii in-in ActLoopNT-in 3.0783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.43, 165.77 APE9-dihe-na 133.07, -137.47 APE8-dihe-in -130.52, 128.21 APE8-rot-in 301.82 APE67-dihe-in -61.46, -22.02 -42.63, -52.7 APE12-dist-in 8.7315 APE11-dist-in 11.6029 APE10-dist-in 6.079 APE9-dist-in 4.1337 S473D TPO308 TPO308 XRAY 2.7 0.217 0.282 B 341.0 320.0 0 28 28 0 [[150, 408]] 1.0 3ocb AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3OW4A P31749 144 478 480.0 SMY:60001 Type1 Active DFGin 6.3863 13.5225 BLAminus -119.32, 159.71 79.63, 82.83 -104.78, 4.01 298.86, 82.1 -54.94, -24.29 in-in in 8.9552 Saltbr-in 2.9022 HRD-in -70.99, -49.36 69.67, -8.21 in-in-in SNCiii in-in ActLoopNT-in 2.9359 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.63, 156.89 APE9-dihe-na 142.86, -142.49 APE8-dihe-in -124.25, 130.13 APE8-rot-in 298.03 APE67-dihe-in -63.26, -12.53 -44.97, -47.55 APE12-dist-in 8.4074 APE11-dist-in 11.4993 APE10-dist-in 5.9428 APE9-dist-in 4.1224 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 A 341.0 318.0 0 28 28 0 [[150, 408]] 1.0 3ow4 AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3OW4B P31749 144 478 480.0 SMY:60002 Type1 Active DFGin 6.4676 13.471 BLAminus -110.6, 166.76 74.64, 94.72 -107.78, 10.54 297.92, 88.21 -53.21, -30.59 in-in in 9.0138 Saltbr-in 2.873 HRD-in -68.95, -46.49 77.32, -19.31 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 158.48 APE9-dihe-na 136.94, -160.6 APE8-dihe-in -112.04, 132.88 APE8-rot-in 279.55 APE67-dihe-in -64.15, -17.53 -43.71, -49.28 APE12-dist-in 8.5672 APE11-dist-in 11.4821 APE10-dist-in 6.0002 APE9-dist-in 4.2086 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 B 341.0 318.0 0 28 28 0 [[150, 408]] 1.0 3ow4 AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3QKLA P31749 144 478 480.0 SMR:60001 Type1 Active DFGin 6.3383 13.6302 BLAminus -120.73, 173.12 65.05, 75.71 -95.61, 13.62 302.87, 90.58 -65.29, -24.68 in-in in 9.0247 Saltbr-in 2.6686 HRD-in -79.32, -50.18 77.61, -12.23 in-in-in SNCiii in-in ActLoopNT-in 2.8075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.72, 167.27 APE9-dihe-na 129.72, -141.45 APE8-dihe-in -129.9, 128.86 APE8-rot-in 291.61 APE67-dihe-in -64.11, -23.78 -46.08, -46.14 APE12-dist-in 8.1494 APE11-dist-in 11.6076 APE10-dist-in 5.9937 APE9-dist-in 3.7066 S473D TPO308 TPO308 XRAY 1.9 0.196 0.243 A 341.0 318.0 0 28 28 0 [[150, 408]] 1.0 3qkl AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3QKMA P31749 144 478 480.0 SM9:1 Type1 Active DFGin 6.5513 13.483 BLAminus -120.8, 163.74 70.66, 92.07 -106.66, 15.27 300.92, 94.29 -62.34, -28.26 in-in in 9.2014 Saltbr-in 2.6655 HRD-in -70.68, -45.98 71.02, -16.64 in-in-in SNCiii in-in ActLoopNT-in 2.8236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.62, 157.36 APE9-dihe-na 116.69, 169.89 APE8-dihe-in -83.27, 128.83 APE8-rot-in 296.3 APE67-dihe-in -66.75, -19.54 -36.8, -50.73 APE12-dist-in 8.4605 APE11-dist-in 11.5248 APE10-dist-in 5.9155 APE9-dist-in 4.6288 S473D TPO308 TPO308 XRAY 2.2 0.191 0.252 A 341.0 330.0 0 28 28 0 [[150, 408]] 1.0 3qkm AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.4963 13.4232 BLAminus -130.08, 156.46 77.16, 99.77 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.9582 Saltbr-in 2.4524 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.7571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.5119 APE10-dist-in 6.0113 APE9-dist-in 4.4431 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341.0 330.0 0 28 28 0 [[150, 408]] 1.0 4ekl AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3CQWA P31749 144 478 480.0 CQW:60999 Type1 Active DFGin 6.3378 13.0904 BLAminus -122.41, 167.11 74.19, 82.7 -100.79, 9.25 295.72, 101.99 -67.19, -25.09 in-in in 8.6085 Saltbr-in 3.4369 HRD-in -79.68, -40.11 70.25, -18.88 in-in-in SNCiii in-in ActLoopNT-in 2.8768 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.61, 166.29 APE9-dihe-na 132.98, -141.71 APE8-dihe-in -134.77, 132.14 APE8-rot-in 286.58 APE67-dihe-in -67.95, -20.8 -49.28, -45.72 APE12-dist-in 8.3741 APE11-dist-in 11.536 APE10-dist-in 5.9337 APE9-dist-in 3.9513 S473D TPO308 TPO308 XRAY 2.0 0.203 0.257 A 342.0 319.0 0 28 28 0 [[150, 408]] 1.0 3cqw AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3MV5A P31749 144 477 480.0 XFE:60999 Type1 Active DFGin 6.5116 13.1066 BLAminus -110.68, 173.87 55.61, 106.15 -116.13, 8.16 292.02, 88.05 -68.88, -21.78 in-in in 8.5726 Saltbr-in 2.6452 HRD-in -81.07, -37.62 75.3, -21.62 in-in-in SNCiii in-in ActLoopNT-in 2.9426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.23, 167.83 APE9-dihe-na 126.38, -137.1 APE8-dihe-in -133.69, 127.23 APE8-rot-in 287.39 APE67-dihe-in -69.19, -14.76 -48.38, -39.25 APE12-dist-in 8.4675 APE11-dist-in 11.6919 APE10-dist-in 6.145 APE9-dist-in 4.1852 S473D TPO308 TPO308 XRAY 2.47 0.205 0.282 A 342.0 316.0 0 28 28 0 [[150, 408]] 1.0 3mv5 AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3MVHA P31749 145 476 480.0 WFE:999 Type1 Active DFGin 6.6088 13.2047 BLAminus -120.33, 157.64 77.18, 89.81 -109.14, 14.39 295.05, 87.49 -62.89, -24.97 in-in in 8.782 Saltbr-in 2.6198 HRD-in -82.77, -44.94 75.58, -15.19 in-in-in SNCiii in-in ActLoopNT-in 2.8364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.65, 167.39 APE9-dihe-na 135.14, -139.29 APE8-dihe-in -137.11, 131.02 APE8-rot-in 291.39 APE67-dihe-in -63.24, -17.86 -53.88, -42.66 APE12-dist-in 8.1485 APE11-dist-in 11.5909 APE10-dist-in 5.8546 APE9-dist-in 3.7556 S473D TPO308 TPO308 XRAY 2.01 0.181 0.23 A 342.0 312.0 0 28 28 0 [[150, 408]] 1.0 3mvh AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6CCYA P31749 144 983 480.0 EX4:60501 Type1 Active DFGin 6.8328 14.2156 BLAminus -118.22, 172.28 65.22, 87.23 -99.08, 6.12 296.87, 97.72 -61.52, -36.28 in-in in 9.3866 Saltbr-in 2.725 HRD-in -70.12, -46.7 65.1, -15.97 in-in-in SNCiii in-in ActLoopNT-in 2.8142 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 164.77 APE9-dihe-na 117.98, 177.81 APE8-dihe-in -89.16, 122.56 APE8-rot-in 287.17 APE67-dihe-in -60.32, -21.6 -32.19, -51.09 APE12-dist-in 8.32 APE11-dist-in 11.4903 APE10-dist-in 5.8107 APE9-dist-in 4.4076 N199S,S396P,E397S,T433V TPO308 TPO308 XRAY 2.18 0.237 0.276 A 343.0 307.0 0 28 28 0 [[150, 408]] 1.0 6ccy AGC_AKT1_HUMAN AGC 4.1e-99 336.9 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3QKKA P31749 144 478 480.0 SMH:60001 Type1.5_Front Active DFGin 6.3829 13.5977 BLAminus -116.54, -179.44 52.7, 85.0 -102.02, 14.36 303.33, 93.01 -66.45, -23.02 in-in in 8.9158 Saltbr-in 2.3424 HRD-in -78.65, -51.68 79.72, -12.12 in-in-in SNCiii in-in ActLoopNT-in 2.7627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.57, 164.52 APE9-dihe-na 135.56, -139.12 APE8-dihe-in -127.86, 127.7 APE8-rot-in 299.02 APE67-dihe-in -62.38, -25.83 -44.42, -46.66 APE12-dist-in 8.2196 APE11-dist-in 11.5656 APE10-dist-in 6.0282 APE9-dist-in 3.7786 S473D TPO308 TPO308 XRAY 2.3 0.202 0.25 A 341.0 327.0 0 28 28 0 [[150, 408]] 1.0 3qkk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3CQUA P31749 144 478 480.0 CQU:60999 Type1 Inactive DFGin 6.1625 12.7524 BLAminus -125.29, 173.04 74.77, 101.51 -111.55, 14.45 309.48, 77.95 -55.91, -32.71 in-out in 9.246 Saltbr-out 4.1128 HRD-in -63.98, -47.97 77.74, -15.86 out-in-in SNCoii in-in ActLoopNT-in 3.0027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.44, 176.23 APE9-dihe-na 125.93, -142.07 APE8-dihe-in -126.34, 131.3 APE8-rot-in 289.37 APE67-dihe-in -62.32, -24.17 -48.41, -45.96 APE12-dist-in 8.3092 APE11-dist-in 11.4552 APE10-dist-in 6.0592 APE9-dist-in 3.9926 S473D TPO308 TPO308 XRAY 2.2 0.207 0.283 A 342.0 319.0 0 28 28 0 [[150, 408]] 1.0 3cqu AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 8UVYA P31749 3 439 480.0 XOO:60502 Allosteric Inactive DFGout 19.1466 9.1172 BBAminus -87.71, 159.46 -125.79, 51.81 -104.71, 8.89 306.76, 157.9 -76.01, 144.81 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.44, -49.7 65.22, 18.47 none-out-out SNCnoo out-out ActLoopNT-out 15.3291 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -75.27, -63.55 APE9-dihe-na -84.1, -150.14 APE8-dihe-in -112.51, 118.73 APE8-rot-in 303.11 APE67-dihe-in -70.02, -8.73 -61.09, -34.89 APE12-dist-in 11.5093 APE11-dist-in 11.9129 APE10-dist-in 7.7033 APE9-dist-out 6.5608 E17K None None XRAY 2.11 0.209 0.255 A 438.0 396.0 21 28 21 7 [[150, 408]] 1.0 8uvy AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 8UW2A P31749 4 437 480.0 XOO:60502 Allosteric Inactive DFGout 19.5938 9.1742 BBAminus -85.5, 157.67 -121.72, 55.74 -105.08, 2.24 304.7, 161.96 -67.3, 146.74 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.89, -48.3 59.85, 6.57 none-out-out SNCnoo out-out ActLoopNT-out 13.6727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.7, 9.37 APE9-dihe-na -151.7, -145.87 APE8-dihe-in -109.15, 106.27 APE8-rot-out 18.96 APE67-dihe-in -70.15, -8.9 -92.15, -6.4 APE12-dist-out 18.0567 APE11-dist-out 14.765 APE10-dist-out 10.6042 APE9-dist-out 11.153 None None None XRAY 2.2 0.223 0.279 A 438.0 392.0 19 28 21 7 [[150, 408]] 1.0 8uw2 AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 8UW9A P31749 3 428 480.0 XQ2:60501 Allosteric Inactive DFGout 18.9763 9.2999 BBAminus -90.79, 158.27 -126.08, 50.43 -104.96, 7.49 302.98, 161.85 -82.17, 151.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.58, -46.97 73.31, -13.02 none-out-out SNCnoo out-out ActLoopNT-out 15.3462 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -78.06, -70.69 APE9-dihe-na -63.13, 144.96 APE8-dihe-in -69.73, 119.44 APE8-rot-in 308.33 APE67-dihe-in -66.64, -12.63 -58.13, -37.16 APE12-dist-in 12.5612 APE11-dist-in 12.0256 APE10-dist-in 7.5487 APE9-dist-out 6.2077 None None None XRAY 1.9 0.207 0.245 A 438.0 388.0 19 28 21 7 [[150, 408]] 1.0 8uw9 AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 8UW7A P31749 3 439 480.0 XOO:60502 Allosteric Inactive DFGout 19.2684 9.1308 BBAminus -88.27, 162.56 -129.0, 47.08 -101.62, 6.17 304.62, 157.46 -65.02, 141.6 out-out out 14.1846 Saltbr-out 16.1635 HRD-in -77.74, -48.14 69.36, -7.13 out-out-out SNCooo out-out ActLoopNT-out 15.1332 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.57 APE8-dihe-in -110.93, 76.79 APE8-rot-out 38.95 APE67-dihe-in -76.05, -14.39 -64.32, -17.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8313 None None YCM77,YCM296 XRAY 1.972 0.22 0.265 A 438.0 399.0 17 28 16 12 [[150, 408]] 1.0 8uw7 AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 3O96A P31749 2 429 480.0 IQO:444 Allosteric Inactive DFGout 16.1303 7.7675 BBAminus -84.04, 164.11 -138.96, 67.69 -114.58, 18.46 294.17, 141.85 -57.09, 121.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.54, -46.27 73.79, -8.96 none-out-none SNCnon out-none ActLoopNT-out 14.7046 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.73, -20.88 999.0, -53.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.249 0.308 A 446.0 367.0 24 28 14 14 [[150, 408]] 1.0 3o96 AGC_AKT1_HUMAN AGC 5.2e-99 336.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6HHHA P31749 2 439 480.0 G4Q:501 Allosteric Inactive DFGout 19.4323 8.9039 BBAminus -82.84, 168.78 -138.99, 51.81 -104.05, 22.45 309.63, 151.96 -74.89, 142.62 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.92, -45.22 71.01, -6.93 none-out-out SNCnoo out-out ActLoopNT-out 15.6586 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.4 APE8-dihe-out -68.07, -39.94 APE8-rot-out 43.05 APE67-dihe-in -61.63, -40.25 -82.49, 7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.3905 E114A,E115A,E116A None None XRAY 2.7 0.217 0.266 A 446.0 379.0 25 28 17 11 [[150, 408]] 1.0 6hhh AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6HHJA P31749 3 444 480.0 G4H:501 Allosteric Inactive DFGout 18.637 9.9266 BBAminus -85.85, 154.25 -131.76, 65.33 -114.43, 2.7 306.85, 152.03 -81.33, 157.37 out-out out 16.597 Saltbr-out 20.7843 HRD-in -70.38, -43.13 62.3, -0.73 out-out-out SNCooo out-out ActLoopNT-out 15.3977 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -96.59, 105.04 APE9-dihe-na 69.68, -150.96 APE8-dihe-in -112.16, 140.11 APE8-rot-out 58.43 APE67-dihe-in -58.84, -27.51 -94.58, 2.39 APE12-dist-out 16.4933 APE11-dist-out 16.0341 APE10-dist-out 10.6835 APE9-dist-out 11.2976 E114A,E115A,E116A None None XRAY 2.3 0.223 0.243 A 446.0 410.0 0 28 28 0 [[150, 408]] 1.0 6hhj AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6S9WA P31749 3 444 480.0 L1Z:501 Allosteric Inactive DFGout 18.0142 9.7777 BBAminus -88.23, 159.68 -135.32, 63.28 -108.07, 5.2 307.51, 150.05 -79.62, 159.51 out-out out 16.7193 Saltbr-out 21.0402 HRD-in -77.04, -47.59 74.55, -19.15 out-out-out SNCooo out-out ActLoopNT-out 15.6766 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.76, 103.74 APE9-dihe-na 82.07, -166.58 APE8-dihe-in -98.52, 141.96 APE8-rot-out 173.15 APE67-dihe-in -62.82, -22.8 -94.37, -0.32 APE12-dist-out 16.6162 APE11-dist-out 16.1389 APE10-dist-out 10.9129 APE9-dist-out 11.1243 E114A,E115A,E116A None None XRAY 2.3 0.21 0.263 A 446.0 411.0 2 28 26 2 [[150, 408]] 1.0 6s9w AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 4EJNA P31749 4 438 480.0 0R4:501 Type1 Inactive DFGout 18.3736 8.3285 BBAminus -86.73, 154.01 -129.51, 54.97 -106.79, 23.78 305.4, 154.78 -69.14, 128.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -74.68, -58.46 77.98, 6.43 none-out-out SNCnoo out-out ActLoopNT-out 16.0646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -97.72, 139.0 APE9-dihe-na 109.04, 163.38 APE8-dihe-in -97.01, 108.52 APE8-rot-in 315.65 APE67-dihe-in -57.15, -23.24 -58.45, -30.75 APE12-dist-out 14.9548 APE11-dist-in 13.3946 APE10-dist-out 8.1576 APE9-dist-out 6.5009 E114A,E115A,E116A None None XRAY 2.19 0.239 0.276 A 446.0 376.0 18 28 23 5 [[150, 408]] 1.0 4ejn AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 5KCVA P31749 6 438 480.0 6S1:501 Allosteric Inactive DFGout 18.3992 8.5934 None -66.09, 150.37 -131.74, 48.39 -109.26, 34.53 301.12, 163.72 -73.63, 124.84 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.28, -36.69 71.61, -16.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.9, -11.63 999.0, -43.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E114A,E115A,E116A None None XRAY 2.7 0.213 0.269 A 460.0 353.0 33 28 12 16 [[150, 408]] 1.0 5kcv AGC_AKT1_HUMAN AGC 5.6e-99 336.5 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 7APJA P31749 3 439 480.0 No_ligand No_ligand Inactive DFGout 15.3603 7.8471 None -119.51, 172.58 -151.35, 78.25 -78.82, 999.0 276.7, 1.08 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.58, -35.61 73.77, -41.9 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.92 APE8-rot-out 58.45 APE67-dihe-in -70.85, -7.62 -68.6, -17.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S2N None None XRAY 2.05 0.213 0.252 A 440.0 376.0 39 28 10 18 [[150, 408]] 1.0 7apj AGC_AKT1_HUMAN AGC 5e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6HHFA P31749 3 439 480.0 G4K:501 Allosteric Inactive None 999.0 8.9427 None -81.4, 157.14 -136.1, 63.0 -116.97, 21.98 304.54, 147.84 -76.24, 135.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -42.11 68.98, -10.23 none-out-out SNCnoo out-out ActLoopNT-out 16.0259 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.64 APE8-rot-out 65.96 APE67-dihe-in -73.6, -35.94 -67.69, -4.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E114A,E115A,E116A None None XRAY 2.9 0.233 0.274 A 446.0 366.0 32 28 14 14 [[150, 408]] 1.0 6hhf AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6HHGA P31749 3 444 480.0 G4T:501 Allosteric Inactive None 999.0 9.8614 None -89.51, 153.73 -128.41, 67.53 -114.64, 10.8 307.59, 150.55 -85.41, 154.74 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.28, -46.2 67.11, -14.18 none-out-out SNCnoo out-out ActLoopNT-out 15.289 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.85, 97.08 APE9-dihe-na 87.64, -165.9 APE8-dihe-in -105.98, 137.43 APE8-rot-out 58.9 APE67-dihe-in -57.38, -21.16 -89.5, -4.41 APE12-dist-out 17.3665 APE11-dist-out 16.1793 APE10-dist-out 10.8884 APE9-dist-out 11.4469 E114A,E115A,E116A None None XRAY 2.3 0.212 0.246 A 446.0 386.0 21 28 25 3 [[150, 408]] 1.0 6hhg AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6HHIA P31749 3 444 480.0 G4N:501 Allosteric Inactive None 999.0 9.3942 None -89.1, 165.97 -135.32, 55.99 -110.01, 13.3 309.82, 146.72 -70.54, 150.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.6, -44.24 72.4, -22.65 none-out-out SNCnoo out-out ActLoopNT-out 15.413 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -105.21, 101.21 APE9-dihe-na 81.98, -162.79 APE8-dihe-in -113.39, 139.7 APE8-rot-out 66.27 APE67-dihe-in -49.46, -24.76 -86.47, -13.4 APE12-dist-out 17.0967 APE11-dist-out 15.7725 APE10-dist-out 10.8529 APE9-dist-out 11.0141 E114A,E115A,E116A None None XRAY 2.7 0.229 0.258 A 446.0 389.0 19 28 25 3 [[150, 408]] 1.0 6hhi AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 6S9XA P31749 3 443 480.0 L1W:501 Allosteric Inactive None 999.0 9.4712 None -83.65, 171.5 -148.58, 59.04 -110.35, 19.84 309.98, 147.1 -81.71, 151.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.64, -44.34 67.14, 2.45 none-out-out SNCnoo out-out ActLoopNT-out 15.6545 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.24, 142.43 APE9-dihe-na 73.42, -170.52 APE8-dihe-in -106.82, 110.63 APE8-rot-out 60.31 APE67-dihe-in -66.32, -9.87 -76.1, -5.54 APE12-dist-none 999.0 APE11-dist-out 16.2423 APE10-dist-out 10.7153 APE9-dist-out 10.2874 E114A,E115A,E116A None None XRAY 2.6 0.214 0.234 A 446.0 382.0 23 28 21 7 [[150, 408]] 1.0 6s9x AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 7NH4A P31749 4 444 480.0 UCE:501 Allosteric Inactive None 999.0 9.7144 None -89.66, 161.99 -134.99, 53.83 -102.41, 15.77 307.61, 150.23 -85.21, 156.95 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.71, -43.96 65.0, -1.87 none-out-out SNCnoo out-out ActLoopNT-out 15.7097 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.29, 122.41 APE9-dihe-na 62.81, -158.06 APE8-dihe-in -116.84, 141.55 APE8-rot-out 65.03 APE67-dihe-in -52.37, -30.57 -89.05, -2.1 APE12-dist-out 16.8195 APE11-dist-out 16.1233 APE10-dist-out 10.7052 APE9-dist-out 11.1488 E114A,E115A,E116A None None XRAY 2.3 0.224 0.246 A 446.0 383.0 24 28 22 6 [[150, 408]] 1.0 7nh4 AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 7NH5A P31749 3 444 480.0 UC8:502 Allosteric Inactive None 999.0 9.683 None -94.24, 161.49 -131.31, 59.8 -111.8, 8.17 304.51, 156.46 -83.9, 163.26 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.19, -47.43 76.17, -13.35 none-out-out SNCnoo out-out ActLoopNT-out 15.6159 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -89.96, 112.26 APE9-dihe-na 68.59, -149.12 APE8-dihe-in -121.33, 137.31 APE8-rot-in 284.5 APE67-dihe-in -57.38, -14.67 -81.19, -19.07 APE12-dist-none 999.0 APE11-dist-out 15.9733 APE10-dist-out 10.4452 APE9-dist-out 11.4343 E114A,E115A,E116A None None XRAY 1.9 0.201 0.228 A 446.0 383.0 24 28 21 7 [[150, 408]] 1.0 7nh5 AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase

AGC_AKT1 (RAC-alpha serine/threonine-protein kinase)

Total number of chains: 39
Active chains: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 56.4% AF-P31749-K1A
DFGout BBAminus 9 23.1% 6HHJA
None None 6 15.4% 6HHIA
DFGout None 2 5.1% 5KCVA

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0476 13.1126 BLAminus -112.5, -177.27 66.46, 90.66 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.6509 Saltbr-in 2.9785 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.0497 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.8136 APE11-dist-in 11.7177 APE10-dist-in 6.0702 APE9-dist-in 4.0693 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0752 13.0461 BLAminus -112.98, 175.61 60.18, 117.01 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.7662 Saltbr-in 2.6652 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.7699 APE11-dist-in 11.6858 APE10-dist-in 6.1252 APE9-dist-in 4.2849 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN AF-P31749-K1A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 6.2627 13.1451 BLAminus -114.62, -167.38 40.57, 67.78 -78.23, 20.61 301.26, 84.0 -56.98, -40.88 in-in in 8.6803 Saltbr-in 2.6805 HRD-in -78.93, -42.17 64.1, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.8678 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.25, 159.39 APE9-dihe-na 136.34, -176.15 APE8-dihe-in -90.74, 129.43 APE8-rot-in 299.37 APE67-dihe-in -70.7, -14.81 -47.91, -45.56 APE12-dist-in 8.3219 APE11-dist-in 11.7485 APE10-dist-in 6.046 APE9-dist-in 3.7787 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[150, 408]] 1.0 AF-P31749-K1 Homo sapiens AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN AF-P31749-K3A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 5.8611 13.3307 BLAminus -119.71, -175.9 43.31, 87.62 -90.32, 18.66 297.34, 81.96 -61.74, -29.8 in-in in 8.7895 Saltbr-in 2.6984 HRD-in -81.85, -49.76 69.24, 0.24 in-in-in SNCiii in-in ActLoopNT-in 2.8866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.64, 153.01 APE9-dihe-na 135.73, 179.27 APE8-dihe-in -81.81, 130.02 APE8-rot-in 289.58 APE67-dihe-in -69.79, -14.8 -47.58, -43.93 APE12-dist-in 8.4868 APE11-dist-in 11.4734 APE10-dist-in 5.8661 APE9-dist-in 4.2622 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[150, 408]] 1.0 AF-P31749-K3 Homo sapiens AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6BUUA P31749 144 478 480.0 No_ligand No_ligand Active DFGin 6.4595 13.5609 BLAminus -129.81, 166.71 63.43, 103.36 -112.37, 8.26 300.4, 87.1 -62.82, -21.63 in-in in 8.5651 Saltbr-in 3.3205 HRD-in -78.21, -43.42 65.34, -10.93 in-in-in SNCiii in-in ActLoopNT-in 2.7848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.8, 159.61 APE9-dihe-na 139.87, -147.27 APE8-dihe-in -120.07, 129.86 APE8-rot-in 299.9 APE67-dihe-in -65.46, -21.29 -53.54, -42.3 APE12-dist-in 8.7204 APE11-dist-in 11.7316 APE10-dist-in 6.2384 APE9-dist-in 4.0846 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.4 0.185 0.23 A 337.0 323.0 0 28 28 0 [[150, 408]] 1.0 6buu Homo sapiens AGC_AKT1_HUMAN AGC 2.2e-99 337.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6BUUB P31749 144 477 480.0 No_ligand No_ligand Active DFGin 6.4216 13.4748 BLAminus -128.87, 158.63 82.78, 97.45 -111.26, 12.46 302.86, 92.31 -62.01, -29.27 in-in in 8.6218 Saltbr-in 2.6118 HRD-in -74.01, -46.33 68.16, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.9455 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.84, 167.54 APE9-dihe-na 132.85, -158.22 APE8-dihe-in -118.97, 130.29 APE8-rot-in 299.43 APE67-dihe-in -70.47, -18.64 -52.17, -43.37 APE12-dist-in 8.7996 APE11-dist-in 11.7592 APE10-dist-in 6.0782 APE9-dist-in 3.9353 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.4 0.185 0.23 B 337.0 319.0 0 28 28 0 [[150, 408]] 1.0 6buu Homo sapiens AGC_AKT1_HUMAN AGC 2.2e-99 337.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6NPZA P31749 142 478 480.0 No_ligand No_ligand Active DFGin 6.2434 13.5168 BLAminus -119.48, 178.99 63.44, 89.04 -107.85, 9.08 296.64, 94.01 -63.0, -21.88 in-in in 8.9042 Saltbr-in 3.0045 HRD-in -76.14, -48.91 69.19, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.9946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.99, 160.01 APE9-dihe-na 134.89, -153.13 APE8-dihe-in -119.22, 128.69 APE8-rot-in 299.44 APE67-dihe-in -61.81, -21.05 -49.68, -44.36 APE12-dist-in 8.2833 APE11-dist-in 11.5575 APE10-dist-in 5.9575 APE9-dist-in 3.903 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.12 0.188 0.241 A 358.0 322.0 0 28 28 0 [[150, 408]] 1.0 6npz Homo sapiens AGC_AKT1_HUMAN AGC 2.7e-99 337.5 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6NPZB P31749 141 477 480.0 No_ligand No_ligand Active DFGin 6.4917 13.7105 BLAminus -117.03, 171.77 71.96, 91.9 -107.91, 11.41 295.22, 94.23 -65.12, -23.31 in-in in 8.8064 Saltbr-in 3.0893 HRD-in -77.35, -47.58 69.03, -7.27 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.06, 158.85 APE9-dihe-na 134.94, -150.01 APE8-dihe-in -122.61, 125.21 APE8-rot-in 296.0 APE67-dihe-in -68.07, -17.45 -48.75, -43.62 APE12-dist-in 8.4844 APE11-dist-in 11.6913 APE10-dist-in 6.0438 APE9-dist-in 3.8563 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.12 0.188 0.241 B 358.0 323.0 0 28 28 0 [[150, 408]] 1.0 6npz Homo sapiens AGC_AKT1_HUMAN AGC 2.7e-99 337.5 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 4GV1A P31749 144 477 480.0 0XZ:60501 Type1 Active DFGin 6.4884 13.5625 BLAminus -122.36, 161.99 68.48, 91.61 -104.89, 11.22 297.02, 96.69 -63.45, -24.57 in-in in 8.8168 Saltbr-in 2.4724 HRD-in -73.6, -46.3 69.86, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.52, 165.79 APE9-dihe-na 129.18, -173.05 APE8-dihe-in -103.26, 131.39 APE8-rot-in 301.03 APE67-dihe-in -66.34, -18.55 -46.14, -49.45 APE12-dist-in 8.4811 APE11-dist-in 11.5527 APE10-dist-in 5.9982 APE9-dist-in 4.0985 None TPO308 TPO308 XRAY 1.49 0.182 0.21 A 340.0 329.0 0 28 28 0 [[150, 408]] 1.0 4gv1 Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3OCBA P31749 144 478 480.0 XM1:1 Type1 Active DFGin 6.6382 13.8031 BLAminus -116.95, 176.33 66.85, 80.21 -101.71, 15.06 291.18, 80.12 -62.95, -27.15 in-in in 8.7712 Saltbr-in 2.7698 HRD-in -68.69, -47.69 74.78, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.9855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.18, 163.1 APE9-dihe-na 135.15, -135.96 APE8-dihe-in -136.2, 122.51 APE8-rot-in 298.45 APE67-dihe-in -66.42, -19.48 -44.24, -42.98 APE12-dist-in 8.435 APE11-dist-in 11.4893 APE10-dist-in 5.8878 APE9-dist-in 4.0576 S473D TPO308 TPO308 XRAY 2.7 0.217 0.282 A 341.0 316.0 0 28 28 0 [[150, 408]] 1.0 3ocb Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3OCBB P31749 144 478 480.0 XM1:2 Type1 Active DFGin 6.3319 13.3989 BLAminus -134.12, 162.45 65.57, 102.27 -117.67, 11.66 296.51, 86.34 -58.99, -28.22 in-in in 8.8145 Saltbr-in 2.8714 HRD-in -68.9, -44.89 75.11, -22.64 in-in-in SNCiii in-in ActLoopNT-in 3.0783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.43, 165.77 APE9-dihe-na 133.07, -137.47 APE8-dihe-in -130.52, 128.21 APE8-rot-in 301.82 APE67-dihe-in -61.46, -22.02 -42.63, -52.7 APE12-dist-in 8.7315 APE11-dist-in 11.6029 APE10-dist-in 6.079 APE9-dist-in 4.1337 S473D TPO308 TPO308 XRAY 2.7 0.217 0.282 B 341.0 320.0 0 28 28 0 [[150, 408]] 1.0 3ocb Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3OW4A P31749 144 478 480.0 SMY:60001 Type1 Active DFGin 6.3863 13.5225 BLAminus -119.32, 159.71 79.63, 82.83 -104.78, 4.01 298.86, 82.1 -54.94, -24.29 in-in in 8.9552 Saltbr-in 2.9022 HRD-in -70.99, -49.36 69.67, -8.21 in-in-in SNCiii in-in ActLoopNT-in 2.9359 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.63, 156.89 APE9-dihe-na 142.86, -142.49 APE8-dihe-in -124.25, 130.13 APE8-rot-in 298.03 APE67-dihe-in -63.26, -12.53 -44.97, -47.55 APE12-dist-in 8.4074 APE11-dist-in 11.4993 APE10-dist-in 5.9428 APE9-dist-in 4.1224 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 A 341.0 318.0 0 28 28 0 [[150, 408]] 1.0 3ow4 Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3OW4B P31749 144 478 480.0 SMY:60002 Type1 Active DFGin 6.4676 13.471 BLAminus -110.6, 166.76 74.64, 94.72 -107.78, 10.54 297.92, 88.21 -53.21, -30.59 in-in in 9.0138 Saltbr-in 2.873 HRD-in -68.95, -46.49 77.32, -19.31 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 158.48 APE9-dihe-na 136.94, -160.6 APE8-dihe-in -112.04, 132.88 APE8-rot-in 279.55 APE67-dihe-in -64.15, -17.53 -43.71, -49.28 APE12-dist-in 8.5672 APE11-dist-in 11.4821 APE10-dist-in 6.0002 APE9-dist-in 4.2086 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 B 341.0 318.0 0 28 28 0 [[150, 408]] 1.0 3ow4 Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3QKLA P31749 144 478 480.0 SMR:60001 Type1 Active DFGin 6.3383 13.6302 BLAminus -120.73, 173.12 65.05, 75.71 -95.61, 13.62 302.87, 90.58 -65.29, -24.68 in-in in 9.0247 Saltbr-in 2.6686 HRD-in -79.32, -50.18 77.61, -12.23 in-in-in SNCiii in-in ActLoopNT-in 2.8075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.72, 167.27 APE9-dihe-na 129.72, -141.45 APE8-dihe-in -129.9, 128.86 APE8-rot-in 291.61 APE67-dihe-in -64.11, -23.78 -46.08, -46.14 APE12-dist-in 8.1494 APE11-dist-in 11.6076 APE10-dist-in 5.9937 APE9-dist-in 3.7066 S473D TPO308 TPO308 XRAY 1.9 0.196 0.243 A 341.0 318.0 0 28 28 0 [[150, 408]] 1.0 3qkl Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3QKMA P31749 144 478 480.0 SM9:1 Type1 Active DFGin 6.5513 13.483 BLAminus -120.8, 163.74 70.66, 92.07 -106.66, 15.27 300.92, 94.29 -62.34, -28.26 in-in in 9.2014 Saltbr-in 2.6655 HRD-in -70.68, -45.98 71.02, -16.64 in-in-in SNCiii in-in ActLoopNT-in 2.8236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.62, 157.36 APE9-dihe-na 116.69, 169.89 APE8-dihe-in -83.27, 128.83 APE8-rot-in 296.3 APE67-dihe-in -66.75, -19.54 -36.8, -50.73 APE12-dist-in 8.4605 APE11-dist-in 11.5248 APE10-dist-in 5.9155 APE9-dist-in 4.6288 S473D TPO308 TPO308 XRAY 2.2 0.191 0.252 A 341.0 330.0 0 28 28 0 [[150, 408]] 1.0 3qkm Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.4963 13.4232 BLAminus -130.08, 156.46 77.16, 99.77 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.9582 Saltbr-in 2.4524 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.7571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.5119 APE10-dist-in 6.0113 APE9-dist-in 4.4431 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341.0 330.0 0 28 28 0 [[150, 408]] 1.0 4ekl Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3CQWA P31749 144 478 480.0 CQW:60999 Type1 Active DFGin 6.3378 13.0904 BLAminus -122.41, 167.11 74.19, 82.7 -100.79, 9.25 295.72, 101.99 -67.19, -25.09 in-in in 8.6085 Saltbr-in 3.4369 HRD-in -79.68, -40.11 70.25, -18.88 in-in-in SNCiii in-in ActLoopNT-in 2.8768 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.61, 166.29 APE9-dihe-na 132.98, -141.71 APE8-dihe-in -134.77, 132.14 APE8-rot-in 286.58 APE67-dihe-in -67.95, -20.8 -49.28, -45.72 APE12-dist-in 8.3741 APE11-dist-in 11.536 APE10-dist-in 5.9337 APE9-dist-in 3.9513 S473D TPO308 TPO308 XRAY 2.0 0.203 0.257 A 342.0 319.0 0 28 28 0 [[150, 408]] 1.0 3cqw Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3MV5A P31749 144 477 480.0 XFE:60999 Type1 Active DFGin 6.5116 13.1066 BLAminus -110.68, 173.87 55.61, 106.15 -116.13, 8.16 292.02, 88.05 -68.88, -21.78 in-in in 8.5726 Saltbr-in 2.6452 HRD-in -81.07, -37.62 75.3, -21.62 in-in-in SNCiii in-in ActLoopNT-in 2.9426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.23, 167.83 APE9-dihe-na 126.38, -137.1 APE8-dihe-in -133.69, 127.23 APE8-rot-in 287.39 APE67-dihe-in -69.19, -14.76 -48.38, -39.25 APE12-dist-in 8.4675 APE11-dist-in 11.6919 APE10-dist-in 6.145 APE9-dist-in 4.1852 S473D TPO308 TPO308 XRAY 2.47 0.205 0.282 A 342.0 316.0 0 28 28 0 [[150, 408]] 1.0 3mv5 Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3MVHA P31749 145 476 480.0 WFE:999 Type1 Active DFGin 6.6088 13.2047 BLAminus -120.33, 157.64 77.18, 89.81 -109.14, 14.39 295.05, 87.49 -62.89, -24.97 in-in in 8.782 Saltbr-in 2.6198 HRD-in -82.77, -44.94 75.58, -15.19 in-in-in SNCiii in-in ActLoopNT-in 2.8364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.65, 167.39 APE9-dihe-na 135.14, -139.29 APE8-dihe-in -137.11, 131.02 APE8-rot-in 291.39 APE67-dihe-in -63.24, -17.86 -53.88, -42.66 APE12-dist-in 8.1485 APE11-dist-in 11.5909 APE10-dist-in 5.8546 APE9-dist-in 3.7556 S473D TPO308 TPO308 XRAY 2.01 0.181 0.23 A 342.0 312.0 0 28 28 0 [[150, 408]] 1.0 3mvh Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6CCYA P31749 144 983 480.0 EX4:60501 Type1 Active DFGin 6.8328 14.2156 BLAminus -118.22, 172.28 65.22, 87.23 -99.08, 6.12 296.87, 97.72 -61.52, -36.28 in-in in 9.3866 Saltbr-in 2.725 HRD-in -70.12, -46.7 65.1, -15.97 in-in-in SNCiii in-in ActLoopNT-in 2.8142 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 164.77 APE9-dihe-na 117.98, 177.81 APE8-dihe-in -89.16, 122.56 APE8-rot-in 287.17 APE67-dihe-in -60.32, -21.6 -32.19, -51.09 APE12-dist-in 8.32 APE11-dist-in 11.4903 APE10-dist-in 5.8107 APE9-dist-in 4.4076 N199S,S396P,E397S,T433V TPO308 TPO308 XRAY 2.18 0.237 0.276 A 343.0 307.0 0 28 28 0 [[150, 408]] 1.0 6ccy Homo sapiens AGC_AKT1_HUMAN AGC 4.1e-99 336.9 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3QKKA P31749 144 478 480.0 SMH:60001 Type1.5_Front Active DFGin 6.3829 13.5977 BLAminus -116.54, -179.44 52.7, 85.0 -102.02, 14.36 303.33, 93.01 -66.45, -23.02 in-in in 8.9158 Saltbr-in 2.3424 HRD-in -78.65, -51.68 79.72, -12.12 in-in-in SNCiii in-in ActLoopNT-in 2.7627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.57, 164.52 APE9-dihe-na 135.56, -139.12 APE8-dihe-in -127.86, 127.7 APE8-rot-in 299.02 APE67-dihe-in -62.38, -25.83 -44.42, -46.66 APE12-dist-in 8.2196 APE11-dist-in 11.5656 APE10-dist-in 6.0282 APE9-dist-in 3.7786 S473D TPO308 TPO308 XRAY 2.3 0.202 0.25 A 341.0 327.0 0 28 28 0 [[150, 408]] 1.0 3qkk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3CQUA P31749 144 478 480.0 CQU:60999 Type1 Inactive DFGin 6.1625 12.7524 BLAminus -125.29, 173.04 74.77, 101.51 -111.55, 14.45 309.48, 77.95 -55.91, -32.71 in-out in 9.246 Saltbr-out 4.1128 HRD-in -63.98, -47.97 77.74, -15.86 out-in-in SNCoii in-in ActLoopNT-in 3.0027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.44, 176.23 APE9-dihe-na 125.93, -142.07 APE8-dihe-in -126.34, 131.3 APE8-rot-in 289.37 APE67-dihe-in -62.32, -24.17 -48.41, -45.96 APE12-dist-in 8.3092 APE11-dist-in 11.4552 APE10-dist-in 6.0592 APE9-dist-in 3.9926 S473D TPO308 TPO308 XRAY 2.2 0.207 0.283 A 342.0 319.0 0 28 28 0 [[150, 408]] 1.0 3cqu Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 8UVYA P31749 3 439 480.0 XOO:60502 Allosteric Inactive DFGout 19.1466 9.1172 BBAminus -87.71, 159.46 -125.79, 51.81 -104.71, 8.89 306.76, 157.9 -76.01, 144.81 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.44, -49.7 65.22, 18.47 none-out-out SNCnoo out-out ActLoopNT-out 15.3291 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -75.27, -63.55 APE9-dihe-na -84.1, -150.14 APE8-dihe-in -112.51, 118.73 APE8-rot-in 303.11 APE67-dihe-in -70.02, -8.73 -61.09, -34.89 APE12-dist-in 11.5093 APE11-dist-in 11.9129 APE10-dist-in 7.7033 APE9-dist-out 6.5608 E17K None None XRAY 2.11 0.209 0.255 A 438.0 396.0 21 28 21 7 [[150, 408]] 1.0 8uvy Homo sapiens AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 8UW2A P31749 4 437 480.0 XOO:60502 Allosteric Inactive DFGout 19.5938 9.1742 BBAminus -85.5, 157.67 -121.72, 55.74 -105.08, 2.24 304.7, 161.96 -67.3, 146.74 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.89, -48.3 59.85, 6.57 none-out-out SNCnoo out-out ActLoopNT-out 13.6727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.7, 9.37 APE9-dihe-na -151.7, -145.87 APE8-dihe-in -109.15, 106.27 APE8-rot-out 18.96 APE67-dihe-in -70.15, -8.9 -92.15, -6.4 APE12-dist-out 18.0567 APE11-dist-out 14.765 APE10-dist-out 10.6042 APE9-dist-out 11.153 None None None XRAY 2.2 0.223 0.279 A 438.0 392.0 19 28 21 7 [[150, 408]] 1.0 8uw2 Homo sapiens AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 8UW9A P31749 3 428 480.0 XQ2:60501 Allosteric Inactive DFGout 18.9763 9.2999 BBAminus -90.79, 158.27 -126.08, 50.43 -104.96, 7.49 302.98, 161.85 -82.17, 151.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.58, -46.97 73.31, -13.02 none-out-out SNCnoo out-out ActLoopNT-out 15.3462 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -78.06, -70.69 APE9-dihe-na -63.13, 144.96 APE8-dihe-in -69.73, 119.44 APE8-rot-in 308.33 APE67-dihe-in -66.64, -12.63 -58.13, -37.16 APE12-dist-in 12.5612 APE11-dist-in 12.0256 APE10-dist-in 7.5487 APE9-dist-out 6.2077 None None None XRAY 1.9 0.207 0.245 A 438.0 388.0 19 28 21 7 [[150, 408]] 1.0 8uw9 Homo sapiens AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 8UW7A P31749 3 439 480.0 XOO:60502 Allosteric Inactive DFGout 19.2684 9.1308 BBAminus -88.27, 162.56 -129.0, 47.08 -101.62, 6.17 304.62, 157.46 -65.02, 141.6 out-out out 14.1846 Saltbr-out 16.1635 HRD-in -77.74, -48.14 69.36, -7.13 out-out-out SNCooo out-out ActLoopNT-out 15.1332 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.57 APE8-dihe-in -110.93, 76.79 APE8-rot-out 38.95 APE67-dihe-in -76.05, -14.39 -64.32, -17.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8313 None None YCM77,YCM296 XRAY 1.972 0.22 0.265 A 438.0 399.0 17 28 16 12 [[150, 408]] 1.0 8uw7 Homo sapiens AGC_AKT1_HUMAN AGC 4.9e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 3O96A P31749 2 429 480.0 IQO:444 Allosteric Inactive DFGout 16.1303 7.7675 BBAminus -84.04, 164.11 -138.96, 67.69 -114.58, 18.46 294.17, 141.85 -57.09, 121.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.54, -46.27 73.79, -8.96 none-out-none SNCnon out-none ActLoopNT-out 14.7046 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.73, -20.88 999.0, -53.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.249 0.308 A 446.0 367.0 24 28 14 14 [[150, 408]] 1.0 3o96 Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6HHHA P31749 2 439 480.0 G4Q:501 Allosteric Inactive DFGout 19.4323 8.9039 BBAminus -82.84, 168.78 -138.99, 51.81 -104.05, 22.45 309.63, 151.96 -74.89, 142.62 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.92, -45.22 71.01, -6.93 none-out-out SNCnoo out-out ActLoopNT-out 15.6586 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.4 APE8-dihe-out -68.07, -39.94 APE8-rot-out 43.05 APE67-dihe-in -61.63, -40.25 -82.49, 7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.3905 E114A,E115A,E116A None None XRAY 2.7 0.217 0.266 A 446.0 379.0 25 28 17 11 [[150, 408]] 1.0 6hhh Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6HHJA P31749 3 444 480.0 G4H:501 Allosteric Inactive DFGout 18.637 9.9266 BBAminus -85.85, 154.25 -131.76, 65.33 -114.43, 2.7 306.85, 152.03 -81.33, 157.37 out-out out 16.597 Saltbr-out 20.7843 HRD-in -70.38, -43.13 62.3, -0.73 out-out-out SNCooo out-out ActLoopNT-out 15.3977 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -96.59, 105.04 APE9-dihe-na 69.68, -150.96 APE8-dihe-in -112.16, 140.11 APE8-rot-out 58.43 APE67-dihe-in -58.84, -27.51 -94.58, 2.39 APE12-dist-out 16.4933 APE11-dist-out 16.0341 APE10-dist-out 10.6835 APE9-dist-out 11.2976 E114A,E115A,E116A None None XRAY 2.3 0.223 0.243 A 446.0 410.0 0 28 28 0 [[150, 408]] 1.0 6hhj Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6S9WA P31749 3 444 480.0 L1Z:501 Allosteric Inactive DFGout 18.0142 9.7777 BBAminus -88.23, 159.68 -135.32, 63.28 -108.07, 5.2 307.51, 150.05 -79.62, 159.51 out-out out 16.7193 Saltbr-out 21.0402 HRD-in -77.04, -47.59 74.55, -19.15 out-out-out SNCooo out-out ActLoopNT-out 15.6766 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.76, 103.74 APE9-dihe-na 82.07, -166.58 APE8-dihe-in -98.52, 141.96 APE8-rot-out 173.15 APE67-dihe-in -62.82, -22.8 -94.37, -0.32 APE12-dist-out 16.6162 APE11-dist-out 16.1389 APE10-dist-out 10.9129 APE9-dist-out 11.1243 E114A,E115A,E116A None None XRAY 2.3 0.21 0.263 A 446.0 411.0 2 28 26 2 [[150, 408]] 1.0 6s9w Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 4EJNA P31749 4 438 480.0 0R4:501 Type1 Inactive DFGout 18.3736 8.3285 BBAminus -86.73, 154.01 -129.51, 54.97 -106.79, 23.78 305.4, 154.78 -69.14, 128.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -74.68, -58.46 77.98, 6.43 none-out-out SNCnoo out-out ActLoopNT-out 16.0646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -97.72, 139.0 APE9-dihe-na 109.04, 163.38 APE8-dihe-in -97.01, 108.52 APE8-rot-in 315.65 APE67-dihe-in -57.15, -23.24 -58.45, -30.75 APE12-dist-out 14.9548 APE11-dist-in 13.3946 APE10-dist-out 8.1576 APE9-dist-out 6.5009 E114A,E115A,E116A None None XRAY 2.19 0.239 0.276 A 446.0 376.0 18 28 23 5 [[150, 408]] 1.0 4ejn Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 5KCVA P31749 6 438 480.0 6S1:501 Allosteric Inactive DFGout 18.3992 8.5934 None -66.09, 150.37 -131.74, 48.39 -109.26, 34.53 301.12, 163.72 -73.63, 124.84 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.28, -36.69 71.61, -16.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.9, -11.63 999.0, -43.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E114A,E115A,E116A None None XRAY 2.7 0.213 0.269 A 460.0 353.0 33 28 12 16 [[150, 408]] 1.0 5kcv Homo sapiens AGC_AKT1_HUMAN AGC 5.6e-99 336.5 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 7APJA P31749 3 439 480.0 No_ligand No_ligand Inactive DFGout 15.3603 7.8471 None -119.51, 172.58 -151.35, 78.25 -78.82, 999.0 276.7, 1.08 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.58, -35.61 73.77, -41.9 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.92 APE8-rot-out 58.45 APE67-dihe-in -70.85, -7.62 -68.6, -17.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S2N None None XRAY 2.05 0.213 0.252 A 440.0 376.0 39 28 10 18 [[150, 408]] 1.0 7apj Homo sapiens AGC_AKT1_HUMAN AGC 5e-99 336.8 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6HHFA P31749 3 439 480.0 G4K:501 Allosteric Inactive None 999.0 8.9427 None -81.4, 157.14 -136.1, 63.0 -116.97, 21.98 304.54, 147.84 -76.24, 135.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -42.11 68.98, -10.23 none-out-out SNCnoo out-out ActLoopNT-out 16.0259 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.64 APE8-rot-out 65.96 APE67-dihe-in -73.6, -35.94 -67.69, -4.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E114A,E115A,E116A None None XRAY 2.9 0.233 0.274 A 446.0 366.0 32 28 14 14 [[150, 408]] 1.0 6hhf Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6HHGA P31749 3 444 480.0 G4T:501 Allosteric Inactive None 999.0 9.8614 None -89.51, 153.73 -128.41, 67.53 -114.64, 10.8 307.59, 150.55 -85.41, 154.74 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.28, -46.2 67.11, -14.18 none-out-out SNCnoo out-out ActLoopNT-out 15.289 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.85, 97.08 APE9-dihe-na 87.64, -165.9 APE8-dihe-in -105.98, 137.43 APE8-rot-out 58.9 APE67-dihe-in -57.38, -21.16 -89.5, -4.41 APE12-dist-out 17.3665 APE11-dist-out 16.1793 APE10-dist-out 10.8884 APE9-dist-out 11.4469 E114A,E115A,E116A None None XRAY 2.3 0.212 0.246 A 446.0 386.0 21 28 25 3 [[150, 408]] 1.0 6hhg Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6HHIA P31749 3 444 480.0 G4N:501 Allosteric Inactive None 999.0 9.3942 None -89.1, 165.97 -135.32, 55.99 -110.01, 13.3 309.82, 146.72 -70.54, 150.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.6, -44.24 72.4, -22.65 none-out-out SNCnoo out-out ActLoopNT-out 15.413 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -105.21, 101.21 APE9-dihe-na 81.98, -162.79 APE8-dihe-in -113.39, 139.7 APE8-rot-out 66.27 APE67-dihe-in -49.46, -24.76 -86.47, -13.4 APE12-dist-out 17.0967 APE11-dist-out 15.7725 APE10-dist-out 10.8529 APE9-dist-out 11.0141 E114A,E115A,E116A None None XRAY 2.7 0.229 0.258 A 446.0 389.0 19 28 25 3 [[150, 408]] 1.0 6hhi Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 6S9XA P31749 3 443 480.0 L1W:501 Allosteric Inactive None 999.0 9.4712 None -83.65, 171.5 -148.58, 59.04 -110.35, 19.84 309.98, 147.1 -81.71, 151.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.64, -44.34 67.14, 2.45 none-out-out SNCnoo out-out ActLoopNT-out 15.6545 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.24, 142.43 APE9-dihe-na 73.42, -170.52 APE8-dihe-in -106.82, 110.63 APE8-rot-out 60.31 APE67-dihe-in -66.32, -9.87 -76.1, -5.54 APE12-dist-none 999.0 APE11-dist-out 16.2423 APE10-dist-out 10.7153 APE9-dist-out 10.2874 E114A,E115A,E116A None None XRAY 2.6 0.214 0.234 A 446.0 382.0 23 28 21 7 [[150, 408]] 1.0 6s9x Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 7NH4A P31749 4 444 480.0 UCE:501 Allosteric Inactive None 999.0 9.7144 None -89.66, 161.99 -134.99, 53.83 -102.41, 15.77 307.61, 150.23 -85.21, 156.95 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.71, -43.96 65.0, -1.87 none-out-out SNCnoo out-out ActLoopNT-out 15.7097 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.29, 122.41 APE9-dihe-na 62.81, -158.06 APE8-dihe-in -116.84, 141.55 APE8-rot-out 65.03 APE67-dihe-in -52.37, -30.57 -89.05, -2.1 APE12-dist-out 16.8195 APE11-dist-out 16.1233 APE10-dist-out 10.7052 APE9-dist-out 11.1488 E114A,E115A,E116A None None XRAY 2.3 0.224 0.246 A 446.0 383.0 24 28 22 6 [[150, 408]] 1.0 7nh4 Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AKT1 AKT1_HUMAN 7NH5A P31749 3 444 480.0 UC8:502 Allosteric Inactive None 999.0 9.683 None -94.24, 161.49 -131.31, 59.8 -111.8, 8.17 304.51, 156.46 -83.9, 163.26 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.19, -47.43 76.17, -13.35 none-out-out SNCnoo out-out ActLoopNT-out 15.6159 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -89.96, 112.26 APE9-dihe-na 68.59, -149.12 APE8-dihe-in -121.33, 137.31 APE8-rot-in 284.5 APE67-dihe-in -57.38, -14.67 -81.19, -19.07 APE12-dist-none 999.0 APE11-dist-out 15.9733 APE10-dist-out 10.4452 APE9-dist-out 11.4343 E114A,E115A,E116A None None XRAY 1.9 0.201 0.228 A 446.0 383.0 24 28 21 7 [[150, 408]] 1.0 7nh5 Homo sapiens AGC_AKT1_HUMAN AGC 5.2e-99 336.6 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase

AGC_AKT1 (RAC-alpha serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name