Protein kinases in complex with LU8

Total number of genes: 2
Total number of chains: 100
Spatial Dihedral Chains Representative
DFGin BLAminus 90 6SRHB
DFGout None 10 8XFYA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYA 3.2 Inactive DFGout None out-out out-out A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYB 3.2 Inactive DFGout None out-out out-out A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYC 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYD 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYE 3.2 Inactive DFGout None none-none out-in A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYF 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYG 3.2 Inactive DFGout None in-out out-in A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYH 3.2 Inactive DFGout None out-out out-in A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYI 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYJ 3.2 Inactive DFGout None none-none out-in A1LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7QB 1.53 Inactive DFGin BLAminus in-out in-in XJM LU8 XJM Allosteric Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S77B 1.31 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S78B 1.3 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S79B 1.5 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7GB 1.78 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7HB 1.3 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7JB 1.31 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7PB 1.31 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7WB 1.33 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S83B 1.33 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S84B 1.35 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S89B 1.3 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 6SRHA 1.25 Inactive DFGin BLAminus in-out in-in LU8 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7BB 1.32 Inactive DFGin BLAminus in-out in-in LU8 XH7 Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7CB 1.31 Inactive DFGin BLAminus in-out in-in LU8 T5Y Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7DB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XHD Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7EB 1.32 Inactive DFGin BLAminus in-out in-in LU8 XEA Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7KB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XEJ Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7MB 1.32 Inactive DFGin BLAminus in-out in-in LU8 HVK Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7NB 1.3 Inactive DFGin BLAminus in-out in-in LU8 2AI Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7SB 1.3 Inactive DFGin BLAminus in-out in-in LU8 09V Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7VB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XH1 Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7XB 1.3 Inactive DFGin BLAminus in-out in-in LU8 LGA Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7ZB 1.3 Inactive DFGin BLAminus in-out in-in LU8 BYZ Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S82B 1.71 Inactive DFGin BLAminus in-out in-in LU8 LAC Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S86B 1.31 Inactive DFGin BLAminus in-out in-in LU8 XK7 Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S87B 1.3 Inactive DFGin BLAminus in-out in-in LU8 XKD Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S88B 1.31 Inactive DFGin BLAminus in-out in-in LU8 XKS Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8AB 1.3 Inactive DFGin BLAminus in-out in-in LU8 XKY Type1 Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S75B 1.3 Inactive DFGin BLAminus in-out in-in LU8 HUH HUH Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S79A 1.5 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7AB 1.3 Inactive DFGin BLAminus in-out in-in LU8 T5V T5V Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7EA 1.32 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7FA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7FB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XH4 XH4 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7GA 1.78 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7OA 1.43 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7QA 1.53 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7UA 1.59 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7UB 1.59 Inactive DFGin BLAminus in-out in-in LU8 XGY XGY Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7VA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7WA 1.33 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7YA 1.37 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S80A 1.67 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S80B 1.67 Inactive DFGin BLAminus in-out in-in LU8 XGM XGM Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S82A 1.71 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S87A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S88A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S9KA 1.35 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 6SRHB 1.25 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S77A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 BAQ Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7DA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XHD Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7JA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XHG Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7KA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XEJ Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7LA 1.36 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XHJ Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7MA 1.32 Inactive DFGin BLAminus in-out in-in LU8 LU8 HVK HVK Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7NA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 2AI Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7PA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 V1L Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7SA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 09V Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7TB 1.3 Inactive DFGin BLAminus in-out in-in LU8 XGJ XGJ XGJ Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7XA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 LGA Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S86A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XK7 Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S89A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XKV Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8AA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XKY Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8BB 1.64 Inactive DFGin BLAminus in-out in-in LU8 XFV XFV XFV Type1 Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S75A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 HUH HUH Type1 Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7AA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 T5V T5V Type1 Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7BA 1.32 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XH7 XH7 Type1 Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7HA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 HVB HVB Type1 Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7ZA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 BYZ BYZ Type1 Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S81B 1.43 Inactive DFGin BLAminus in-out in-in LU8 XJV XJV XJV XJV Type1 Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7CA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 T5Y T5Y T5Y Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7IA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 HV2 HV2 HV2 Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7TA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XGJ XGJ XGJ Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7YB 1.37 Inactive DFGin BLAminus in-out in-in LU8 XJP XJP XJP XJP XJP Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7RB 1.46 Inactive DFGin BLAminus in-out in-in LU8 XGS XGS XGS XGS XGS XGS Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S85A 1.33 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XK4 XK4 XK4 XK4 Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8BA 1.64 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XFV XFV XFV XFV Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7RA 1.46 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XGS XGS XGS XGS XGS Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7IB 1.3 Inactive DFGin BLAminus in-out in-in LU8 HV2 HV2 HV2 HV2 HV2 HV2 HV2 HV2 HV2 Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S78A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XGV XGV XGV Type1 Allosteric Allosteric Allosteric Allosteric Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S81A 1.43 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XJV XJV Type1 Allosteric Allosteric Allosteric Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S76A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 02A 02A Type1 Allosteric Allosteric Allosteric Type1.5_Back
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7LB 1.36 Inactive DFGin BLAminus in-out in-in LU8 XHJ XHJ XHJ XHJ Type1 Allosteric Allosteric Allosteric Type3
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S84A 1.35 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XK1 Type1 Allosteric Allosteric Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S83A 1.33 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XJY Type1 Allosteric Allosteric Type3
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7OB 1.43 Inactive DFGin BLAminus in-out in-in LU8 XJJ Type1 Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S85B 1.33 Inactive DFGin BLAminus in-out in-in LU8 XK4 XK4 XK4 Type1 Type1 Allosteric Allosteric
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S76B 1.31 Inactive DFGin BLAminus in-out in-in LU8 02A Type1 Type1.5_Back
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S9KB 1.35 Inactive DFGin BLAminus in-out in-in LU8 YV4 Type1 Type3

Protein kinases in complex with LU8

Total number of genes: 2
Total number of chains: 100
Spatial Dihedral Chains Representative
DFGin BLAminus 90 6SRHB
DFGout None 10 8XFYA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYA 3.2 Inactive DFGout None out-out out-out A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYB 3.2 Inactive DFGout None out-out out-out A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYC 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYD 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYE 3.2 Inactive DFGout None none-none out-in A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYF 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYG 3.2 Inactive DFGout None in-out out-in A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYH 3.2 Inactive DFGout None out-out out-in A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYI 3.2 Inactive DFGout None none-none out-out A1LU8 Type1
Homo sapiens AGC RPS6KA3 KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 8XFYJ 3.2 Inactive DFGout None none-none out-in A1LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7QB 1.53 Inactive DFGin BLAminus in-out in-in XJM LU8 XJM Allosteric Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S77B 1.31 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S78B 1.3 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S79B 1.5 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7GB 1.78 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7HB 1.3 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7JB 1.31 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7PB 1.31 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7WB 1.33 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S83B 1.33 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S84B 1.35 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S89B 1.3 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 6SRHA 1.25 Inactive DFGin BLAminus in-out in-in LU8 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7BB 1.32 Inactive DFGin BLAminus in-out in-in LU8 XH7 Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7CB 1.31 Inactive DFGin BLAminus in-out in-in LU8 T5Y Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7DB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XHD Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7EB 1.32 Inactive DFGin BLAminus in-out in-in LU8 XEA Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7KB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XEJ Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7MB 1.32 Inactive DFGin BLAminus in-out in-in LU8 HVK Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7NB 1.3 Inactive DFGin BLAminus in-out in-in LU8 2AI Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7SB 1.3 Inactive DFGin BLAminus in-out in-in LU8 09V Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7VB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XH1 Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7XB 1.3 Inactive DFGin BLAminus in-out in-in LU8 LGA Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7ZB 1.3 Inactive DFGin BLAminus in-out in-in LU8 BYZ Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S82B 1.71 Inactive DFGin BLAminus in-out in-in LU8 LAC Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S86B 1.31 Inactive DFGin BLAminus in-out in-in LU8 XK7 Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S87B 1.3 Inactive DFGin BLAminus in-out in-in LU8 XKD Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S88B 1.31 Inactive DFGin BLAminus in-out in-in LU8 XKS Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8AB 1.3 Inactive DFGin BLAminus in-out in-in LU8 XKY Type1 Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S75B 1.3 Inactive DFGin BLAminus in-out in-in LU8 HUH HUH Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S79A 1.5 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7AB 1.3 Inactive DFGin BLAminus in-out in-in LU8 T5V T5V Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7EA 1.32 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7FA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7FB 1.31 Inactive DFGin BLAminus in-out in-in LU8 XH4 XH4 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7GA 1.78 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7OA 1.43 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7QA 1.53 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7UA 1.59 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7UB 1.59 Inactive DFGin BLAminus in-out in-in LU8 XGY XGY Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7VA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7WA 1.33 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7YA 1.37 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S80A 1.67 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S80B 1.67 Inactive DFGin BLAminus in-out in-in LU8 XGM XGM Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S82A 1.71 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S87A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S88A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S9KA 1.35 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 6SRHB 1.25 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S77A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 BAQ Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7DA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XHD Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7JA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XHG Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7KA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XEJ Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7LA 1.36 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XHJ Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7MA 1.32 Inactive DFGin BLAminus in-out in-in LU8 LU8 HVK HVK Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7NA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 2AI Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7PA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 V1L Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7SA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 09V Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7TB 1.3 Inactive DFGin BLAminus in-out in-in LU8 XGJ XGJ XGJ Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7XA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 LGA Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S86A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XK7 Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S89A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XKV Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8AA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XKY Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8BB 1.64 Inactive DFGin BLAminus in-out in-in LU8 XFV XFV XFV Type1 Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S75A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 HUH HUH Type1 Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7AA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 T5V T5V Type1 Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7BA 1.32 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XH7 XH7 Type1 Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7HA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 HVB HVB Type1 Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7ZA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 BYZ BYZ Type1 Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S81B 1.43 Inactive DFGin BLAminus in-out in-in LU8 XJV XJV XJV XJV Type1 Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7CA 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 T5Y T5Y T5Y Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7IA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 HV2 HV2 HV2 Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7TA 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XGJ XGJ XGJ Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7YB 1.37 Inactive DFGin BLAminus in-out in-in LU8 XJP XJP XJP XJP XJP Type1 Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7RB 1.46 Inactive DFGin BLAminus in-out in-in LU8 XGS XGS XGS XGS XGS XGS Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S85A 1.33 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XK4 XK4 XK4 XK4 Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S8BA 1.64 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XFV XFV XFV XFV Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7RA 1.46 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XGS XGS XGS XGS XGS Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7IB 1.3 Inactive DFGin BLAminus in-out in-in LU8 HV2 HV2 HV2 HV2 HV2 HV2 HV2 HV2 HV2 Type1 Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S78A 1.3 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XGV XGV XGV Type1 Allosteric Allosteric Allosteric Allosteric Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S81A 1.43 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XJV XJV Type1 Allosteric Allosteric Allosteric Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S76A 1.31 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 02A 02A Type1 Allosteric Allosteric Allosteric Type1.5_Back
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7LB 1.36 Inactive DFGin BLAminus in-out in-in LU8 XHJ XHJ XHJ XHJ Type1 Allosteric Allosteric Allosteric Type3
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S84A 1.35 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XK1 Type1 Allosteric Allosteric Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S83A 1.33 Inactive DFGin BLAminus in-out in-in LU8 LU8 LU8 XJY Type1 Allosteric Allosteric Type3
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S7OB 1.43 Inactive DFGin BLAminus in-out in-in LU8 XJJ Type1 Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S85B 1.33 Inactive DFGin BLAminus in-out in-in LU8 XK4 XK4 XK4 Type1 Type1 Allosteric Allosteric
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S76B 1.31 Inactive DFGin BLAminus in-out in-in LU8 02A Type1 Type1.5_Back
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 5S9KB 1.35 Inactive DFGin BLAminus in-out in-in LU8 YV4 Type1 Type3

Protein kinases in complex with LU8

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type