RPS6KA3 (Ribosomal protein S6 kinase alpha-3)

RPS6KA3 has two kinase domains in its sequence, labeled here as RPS6KA3-1 and RPS6KA3-2. Structures with both domains are given in the last table and labeled as RPS6KA3-12.
Domain_1: RPS6KA3-1
Group: AGC
Example Uniprot: KS6A3_HUMAN
Domain boundary: 68 - 327

Total number of chains: 28
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P51812-K1A
DFGin ABAminus 2 4NW6A
DFGin None 5 7OPOA
DFGinter None 2 7OPOG
DFGout None 18 4NUSA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens KS6A3_HUMAN 4NW5A 1.94 Inactive DFGin ABAminus in-in in-in 2NR Type1 51 - 359 None None 0
Homo sapiens KS6A3_HUMAN 4NW6A 1.74 Inactive DFGin ABAminus in-in in-in 2NS Type1 51 - 359 None None 0
Homo sapiens KS6A3_HUMAN AF-P51812-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 60 - 335 None None 0
Homo sapiens KS6A3_HUMAN 7OPOA 2.75 Inactive DFGin None none-none out-none ANP Type1 45 - 348 None None 2
Homo sapiens KS6A3_HUMAN 7OPOE 2.75 Inactive DFGin None none-none out-none ANP Type1 46 - 348 None None 2
Homo sapiens KS6A3_HUMAN 7OPOI 2.75 Inactive DFGin None none-none out-none ANP Type1 46 - 348 None None 3
Homo sapiens KS6A3_HUMAN 7OPOK 2.75 Inactive DFGin None none-none out-none ANP Type1 46 - 348 None None 2
Homo sapiens KS6A3_HUMAN 7OPOC 2.75 Inactive DFGinter None none-none out-out ANP Type1 46 - 347 None None 0
Homo sapiens KS6A3_HUMAN 7OPOG 2.75 Inactive DFGinter None out-out out-none ANP Type1 46 - 348 None None 2
Homo sapiens KS6A3_HUMAN 8EQ5A 1.8 Inactive DFGout None none-none out-out QCT Type1 49 - 346 None None 2
Homo sapiens KS6A3_HUMAN 8XFYA 3.2 Inactive DFGout None out-out out-out A1LU8 Type1 58 - 358 None None 9
Homo sapiens KS6A3_HUMAN 8XFYB 3.2 Inactive DFGout None out-out out-out A1LU8 Type1 59 - 358 None None 10
Homo sapiens KS6A3_HUMAN 8XFYC 3.2 Inactive DFGout None none-none out-out A1LU8 Type1 61 - 358 None None 10
Homo sapiens KS6A3_HUMAN 8XFYD 3.2 Inactive DFGout None none-none out-out A1LU8 Type1 63 - 348 None None 10
Homo sapiens KS6A3_HUMAN 8XFYE 3.2 Inactive DFGout None none-none out-in A1LU8 Type1 64 - 348 None None 9
Homo sapiens KS6A3_HUMAN 8XFYF 3.2 Inactive DFGout None none-none out-out A1LU8 Type1 63 - 345 None None 11
Homo sapiens KS6A3_HUMAN 8XFYG 3.2 Inactive DFGout None in-out out-in A1LU8 Type1 59 - 346 None None 10
Homo sapiens KS6A3_HUMAN 8XFYH 3.2 Inactive DFGout None out-out out-in A1LU8 Type1 59 - 348 None None 10
Homo sapiens KS6A3_HUMAN 8XFYI 3.2 Inactive DFGout None none-none out-out A1LU8 Type1 63 - 348 None None 10
Homo sapiens KS6A3_HUMAN 8XFYJ 3.2 Inactive DFGout None none-none out-in A1LU8 Type1 65 - 347 None None 10
Homo sapiens KS6A3_HUMAN 4NUSA 2.39 Inactive DFGout None in-out out-in 2NK Type1 53 - 359 None None 0
Homo sapiens KS6A3_HUMAN 5D9LA 2.15 Inactive DFGout None in-out out-out 583 Type1 49 - 359 None None 12
Homo sapiens KS6A3_HUMAN 5D9KA 2.55 Inactive DFGout None in-out out-in 584 Type1 62 - 359 None None 12
Homo sapiens KS6A3_HUMAN 5D9KB 2.55 Inactive DFGout None in-none out-in 584 Type1 62 - 359 None None 11
Mus musculus KS6A3_MOUSE 3G51A 1.8 Inactive DFGin None none-none out-none ANP Type1 47 - 346 None None 11
Mus musculus KS6A3_MOUSE 3UBDA 1.53 Inactive DFGout None none-none out-out SL0 Type1 49 - 346 None None 5
Mus musculus KS6A3_MOUSE 4EL9A 1.55 Inactive DFGout None none-none out-out AFE Type1 49 - 346 None None 3
Mus musculus KS6A3_MOUSE 4GUEA 1.8 Inactive DFGout None none-none out-out QCT Type1 48 - 346 None None 5

RPS6KA3 (Ribosomal protein S6 kinase alpha-3)

Domain_2: RPS6KA3-2
Group: CAMK
Example Uniprot: KS6A3_HUMAN
Domain boundary: 422 - 679

Total number of chains in: 12
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-P51812-K2A
DFGin ABAminus 2 4D9TA
DFGin None 1 4MAOA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens KS6A3_HUMAN 4D9TA 2.4 Inactive DFGin ABAminus in-in in-out 0JG Type1 415 - 713 None None 0
Homo sapiens KS6A3_HUMAN 4D9UA 2.4 Inactive DFGin ABAminus in-in in-out 0JH Type1 408 - 714 K591E None 0
Homo sapiens KS6A3_HUMAN AF-P51812-K2A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 414 - 687 None None 0
Homo sapiens KS6A3_HUMAN 8XEYA 2.65 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 403 - 714 None None 0
Homo sapiens KS6A3_HUMAN 4JG8A 3.1 Inactive DFGin BLAminus in-in in-out 1LE Type1 415 - 714 T493M None 0
Homo sapiens KS6A3_HUMAN 4JG6A 2.6 Inactive DFGin BLAminus in-in in-out 1LB Type1 406 - 712 None None 0
Homo sapiens KS6A3_HUMAN 4JG7A 3.0 Inactive DFGin BLAminus in-in in-out 1LC Type1 405 - 713 None None 0
Mus musculus KS6A3_MOUSE 5O1SA 1.9 None DFGin BLAminus in-in in-none 9HB 9HB Allosteric Type1 415 - 712 None None 3
Mus musculus KS6A3_MOUSE 2QR7A 2.0 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 417 - 714 K591E None 0
Mus musculus KS6A3_MOUSE 2QR8A 2.0 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 417 - 714 K591E None 0
Mus musculus KS6A3_MOUSE 4M8TA 3.0 Inactive DFGin BLAminus in-in in-out RMM Type1 410 - 712 T493M None 0
Mus musculus KS6A3_MOUSE 4MAOA 2.6 Inactive DFGin None in-in in-out 28D Type1 415 - 712 T493M,K591E None 0

RPS6KA3 (Ribosomal protein S6 kinase alpha-3)

Domain_12: RPS6KA3-12
Total number of chains in: 0. Analysis of 2nd kinase domain given in table below.