Ligand

Protein kinases in complex with BYZ

Total number of genes: 2

Total number of chains: 3

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	2	5S7ZB
None	None	1	6Q3CA

Database table as tsv

Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
CMGC	CDK2	CDK2_HUMAN	Cyclin-dependent kinase 2	6Q3CA	1.29	Inactive	None	None	out-out	out-out	BYZ BYZ	Type1 Type1
TKL	ACVR1	ACVR1_HUMAN	Activin receptor type-1	5S7ZB	1.3	Inactive	DFGin	BLAminus	in-out	in-in	LU8 BYZ	Type1 Allosteric
TKL	ACVR1	ACVR1_HUMAN	Activin receptor type-1	5S7ZA	1.3	Inactive	DFGin	BLAminus	in-out	in-in	LU8 LU8 LU8 BYZ BYZ	Type1 Allosteric Allosteric Allosteric Allosteric

Protein kinases in complex with BYZ

Total number of genes: 2

Total number of chains: 3

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	2	5S7ZB
None	None	1	6Q3CA

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
Homo sapiens	CMGC	CDK2	CDK2_HUMAN	Cyclin-dependent kinase 2	6Q3CA	1.29	Inactive	None	None	out-out	out-out	BYZ BYZ	Type1 Type1
Homo sapiens	TKL	ACVR1	ACVR1_HUMAN	Activin receptor type-1	5S7ZB	1.3	Inactive	DFGin	BLAminus	in-out	in-in	LU8 BYZ	Type1 Allosteric
Homo sapiens	TKL	ACVR1	ACVR1_HUMAN	Activin receptor type-1	5S7ZA	1.3	Inactive	DFGin	BLAminus	in-out	in-in	LU8 LU8 LU8 BYZ BYZ	Type1 Allosteric Allosteric Allosteric Allosteric

Protein kinases in complex with BYZ

Total number of genes: 0

Total number of chains: 0

Spatial	Dihedral	Chains	Representative

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type