DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Group: CMGC
Uniprot: DYRK2_HUMAN
Domain boundary: 222 - 535


Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 29 AF-Q92630-K1A
DFGin None 1 8HLTB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q92630-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 214 - 543 None None 0
3K2LA 2.36 Active DFGin BLAminus in-in in-in No_ligand No_ligand 146 - 543 None X232,X381,X382,X442,X458 0
7DG4A 2.58 Active DFGin BLAminus in-in in-in H5R Type1 215 - 538 None X382,X458 0
7DH9A 2.194 Active DFGin BLAminus in-in in-in H7F Type1 215 - 538 None X382,X458 0
7DHCA 2.592 Active DFGin BLAminus in-in in-in H99 Type1 215 - 538 None X382,X458 0
7DHHA 2.486 Active DFGin BLAminus in-in in-in H7L Type1 215 - 538 None X382,X458 0
7DHKA 2.341 Active DFGin BLAminus in-in in-in H7O Type1 215 - 538 None X382,X458 0
7DHNA 2.38 Inactive DFGin BLAminus in-out in-in H7R Type1 215 - 538 None X382,X458 0
7DHOA 3.29 Active DFGin BLAminus in-in in-in H7U Type1 215 - 538 None X382,X458 0
7DJOA 2.499 Active DFGin BLAminus in-in in-in H80 Type1 215 - 538 None X382,X458 0
7DL6A 2.648 Active DFGin BLAminus in-in in-in H96 Type1 215 - 538 None X382,X458 0
7DH3A 2.33 Active DFGin BLAminus in-in in-in H7C Type1 213 - 538 None X382,X458 0
7DHVA 2.679 Active DFGin BLAminus in-in in-in H7X Type1 212 - 538 None X382,X458 0
4AZFA 2.55 Active DFGin BLAminus in-in in-in 3RA Type1 146 - 536 None X382,X458 0
7EJVA 2.5 Active DFGin BLAminus in-in in-in YK2 Type1 151 - 537 None X382 0
7EJVB 2.5 Inactive DFGin BLAminus in-out in-in YK2 Type1 153 - 543 None X382 0
8HLTA 2.8 Active DFGin BLAminus in-in in-in XSE Type1 151 - 535 None X382 0
3KVWA 2.28 Active DFGin BLAminus in-in in-in IRB Type1 146 - 536 None X382,X458 0
5ZTNA 2.496 Active DFGin BLAminus in-in in-in CUR Type1 146 - 536 None X382,X458 0
5ZTNB 2.496 Active DFGin BLAminus in-in in-in CUR Type1 146 - 536 None X382,X458 0
6HDPA 2.3 Active DFGin BLAminus in-in in-in FZ5 Type1 146 - 542 None X382,X458 0
6HDRA 2.2 Active DFGin BLAminus in-in in-in CC9 Type1 146 - 536 None X382,X458 0
7AKFA 2.6 Active DFGin BLAminus in-in in-in RK5 Type1 146 - 535 None X232,X382,X458 0
7AKHA 2.85 Active DFGin BLAminus in-in in-in RK8 Type1 146 - 535 None X232,X382,X458 0
5LXCA 2.15 Active DFGin BLAminus in-in in-in 7AA Type1 153 - 536 None X382 0
5LXCB 2.15 Active DFGin BLAminus in-in in-in 7AA Type1 153 - 538 None X382 0
5LXDA 2.58 Active DFGin BLAminus in-in in-in 7A7 Type1 153 - 538 None X382 0
5LXDB 2.58 Active DFGin BLAminus in-in in-in 7A7 Type1 153 - 538 None X382 0
6K0JA 2.352 Active DFGin BLAminus in-in in-in CQO Type1 212 - 536 E256N,L349A X382,X458 0
8HLTB 2.8 Inactive DFGin None in-in in-in XSE Type1 151 - 537 None X382 0

DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Group: CMGC
Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 29 AF-Q92630-K1A
DFGin None 1 8HLTB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens DYRK2_HUMAN AF-Q92630-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 214 - 543 None None 0
Homo sapiens DYRK2_HUMAN 3K2LA 2.36 Active DFGin BLAminus in-in in-in No_ligand No_ligand 146 - 543 None X232,X381,X382,X442,X458 0
Homo sapiens DYRK2_HUMAN 7DG4A 2.58 Active DFGin BLAminus in-in in-in H5R Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DH9A 2.194 Active DFGin BLAminus in-in in-in H7F Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DHCA 2.592 Active DFGin BLAminus in-in in-in H99 Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DHHA 2.486 Active DFGin BLAminus in-in in-in H7L Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DHKA 2.341 Active DFGin BLAminus in-in in-in H7O Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DHNA 2.38 Inactive DFGin BLAminus in-out in-in H7R Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DHOA 3.29 Active DFGin BLAminus in-in in-in H7U Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DJOA 2.499 Active DFGin BLAminus in-in in-in H80 Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DL6A 2.648 Active DFGin BLAminus in-in in-in H96 Type1 215 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DH3A 2.33 Active DFGin BLAminus in-in in-in H7C Type1 213 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7DHVA 2.679 Active DFGin BLAminus in-in in-in H7X Type1 212 - 538 None X382,X458 0
Homo sapiens DYRK2_HUMAN 4AZFA 2.55 Active DFGin BLAminus in-in in-in 3RA Type1 146 - 536 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7EJVA 2.5 Active DFGin BLAminus in-in in-in YK2 Type1 151 - 537 None X382 0
Homo sapiens DYRK2_HUMAN 7EJVB 2.5 Inactive DFGin BLAminus in-out in-in YK2 Type1 153 - 543 None X382 0
Homo sapiens DYRK2_HUMAN 8HLTA 2.8 Active DFGin BLAminus in-in in-in XSE Type1 151 - 535 None X382 0
Homo sapiens DYRK2_HUMAN 3KVWA 2.28 Active DFGin BLAminus in-in in-in IRB Type1 146 - 536 None X382,X458 0
Homo sapiens DYRK2_HUMAN 5ZTNA 2.496 Active DFGin BLAminus in-in in-in CUR Type1 146 - 536 None X382,X458 0
Homo sapiens DYRK2_HUMAN 5ZTNB 2.496 Active DFGin BLAminus in-in in-in CUR Type1 146 - 536 None X382,X458 0
Homo sapiens DYRK2_HUMAN 6HDPA 2.3 Active DFGin BLAminus in-in in-in FZ5 Type1 146 - 542 None X382,X458 0
Homo sapiens DYRK2_HUMAN 6HDRA 2.2 Active DFGin BLAminus in-in in-in CC9 Type1 146 - 536 None X382,X458 0
Homo sapiens DYRK2_HUMAN 7AKFA 2.6 Active DFGin BLAminus in-in in-in RK5 Type1 146 - 535 None X232,X382,X458 0
Homo sapiens DYRK2_HUMAN 7AKHA 2.85 Active DFGin BLAminus in-in in-in RK8 Type1 146 - 535 None X232,X382,X458 0
Homo sapiens DYRK2_HUMAN 5LXCA 2.15 Active DFGin BLAminus in-in in-in 7AA Type1 153 - 536 None X382 0
Homo sapiens DYRK2_HUMAN 5LXCB 2.15 Active DFGin BLAminus in-in in-in 7AA Type1 153 - 538 None X382 0
Homo sapiens DYRK2_HUMAN 5LXDA 2.58 Active DFGin BLAminus in-in in-in 7A7 Type1 153 - 538 None X382 0
Homo sapiens DYRK2_HUMAN 5LXDB 2.58 Active DFGin BLAminus in-in in-in 7A7 Type1 153 - 538 None X382 0
Homo sapiens DYRK2_HUMAN 6K0JA 2.352 Active DFGin BLAminus in-in in-in CQO Type1 212 - 536 E256N,L349A X382,X458 0
Homo sapiens DYRK2_HUMAN 8HLTB 2.8 Inactive DFGin None in-in in-in XSE Type1 151 - 537 None X382 0

DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

No non-human structures known.