6K0J

DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)
Group: CMGC
Uniprot: DYRK2_HUMAN
Organism: Homo sapiens
Domain boundary: 222 - 535
Resolu: 2.352

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in CQO Type1 212 - 536 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       221        231        241        251 
QVPHDHVAYR YEVLKVIGKG SFGQVVKAYD HKVHQHVALK 
       261        271        281        291 
MVRNNKRFHR QAAEEIRILE HLRKQDKDNT MNVIHMLENF 
       301        311        321        331 
TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS 
       341        351        361        371 
ILQCLDALHK NRIIHCDAKP ENILLKQQGR SGIKVIDFGS 
       381        391        401        411 
SCYEHQRVYT YIQSRFYRAP EVILGARYGM PIDMWSLGCI 
       421        431        441        451 
LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR 
       461        471        481        491 
AKNFVSSKGY PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP 
       501        511        521        531 
ESREWGNALK GCDDPLFLDF LKQCLEWDPA VRMTPGQALR 

HPWLRAA
Lower-case residues are disordered in structure.
Mutations: E256N,L349A
Phosphorylation: X382,X458