OTHER_AAK1 (AP2-associated protein kinase 1)

Total number of chains: 13
Active chains: 13
Uniprot: AAK1_HUMAN
Kinase Domain Residues: 46 - 313
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-Q2M2I8-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q2M2I8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 38 - 321 0 None None AP2-associated protein kinase 1
AF-Q2M2I8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 38 - 321 0 None None AP2-associated protein kinase 1
4WSQA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KSA Type1 29 - 345 0 None None AP2-associated protein kinase 1
4WSQB 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KSA Type1 33 - 342 0 None None AP2-associated protein kinase 1
8GMCA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 34 - 330 0 None None AP2-associated protein kinase 1
8GMCB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 31 - 330 0 None None AP2-associated protein kinase 1
8GMDA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZRR Type1 34 - 329 0 None None AP2-associated protein kinase 1
8GMDB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZRR Type1 29 - 330 0 None None AP2-associated protein kinase 1
9QB5A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F7I Type1 29 - 343 0 None None AP2-associated protein kinase 1
9QB5B 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F7I Type1 34 - 342 0 None None AP2-associated protein kinase 1
5L4QA 1.97 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LKB Type1 33 - 335 0 None None AP2-associated protein kinase 1
5L4QB 1.97 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LKB Type1 33 - 333 0 None None AP2-associated protein kinase 1
5TE0A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XIN Type1 27 - 345 0 None None AP2-associated protein kinase 1

OTHER_AAK1 (AP2-associated protein kinase 1)

Total number of chains: 23
Active chains: 22
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 95.7% AF-Q2M2I8-K1A
DFGin ABAminus 1 4.3% 7LVIA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AAK1_HUMAN AF-Q2M2I8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 38 - 321 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN AF-Q2M2I8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 38 - 321 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 4WSQA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KSA Type1 29 - 345 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 4WSQB 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KSA Type1 33 - 342 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 8GMCA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 34 - 330 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 8GMCB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 31 - 330 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 8GMDA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZRR Type1 34 - 329 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 8GMDB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZRR Type1 29 - 330 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 9QB5A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F7I Type1 29 - 343 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 9QB5B 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F7I Type1 34 - 342 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 5L4QA 1.97 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LKB Type1 33 - 335 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 5L4QB 1.97 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LKB Type1 33 - 333 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_HUMAN 5TE0A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XIN Type1 27 - 345 0 None None AP2-associated protein kinase 1 Homo sapiens
AAK1_MOUSE 7LVHA 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFS Type1 34 - 328 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7LVHB 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 329 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7LVIB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ6A 2.132 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ6B 2.132 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5OI Type1 32 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ7A 2.124 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5P6 Type1 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ7B 2.124 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5P6 Type1 31 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ8A 2.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5QI, PG6 Type1, Allosteric 33 - 329 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ8B 2.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV, PG6 Type1, Allosteric 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7LVIA 2.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFY Type1 34 - 330 0 None None AP2-associated protein kinase 1 Mus musculus

OTHER_AAK1 (AP2-associated protein kinase 1)

Total number of chains: 10
Active chains: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 90.0% 7RJ7B
DFGin ABAminus 1 10.0% 7LVIA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AAK1_MOUSE 7LVHA 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFS Type1 34 - 328 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7LVHB 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 329 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7LVIB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ6A 2.132 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ6B 2.132 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5OI Type1 32 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ7A 2.124 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5P6 Type1 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ7B 2.124 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5P6 Type1 31 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ8A 2.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5QI, PG6 Type1, Allosteric 33 - 329 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7RJ8B 2.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV, PG6 Type1, Allosteric 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
AAK1_MOUSE 7LVIA 2.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFY Type1 34 - 330 0 None None AP2-associated protein kinase 1 Mus musculus