Ligand: TZ0 (Futibatinib)

Total number of chains: 16
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 75.0% 8W3DA
DFGin BLAplus 3 18.8% 6MZWA
DFGin None 1 6.2% 6MZWB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR FGFR1 FGFR1_HUMAN 6MZQA 2.0 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 464 - 765 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6MZQB 2.0 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 462 - 761 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6MZWA 2.2 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 464 - 765 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 6MZWB 2.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 463 - 762 0 None None Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 8W3BA 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3BB 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3BC 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3BD 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 465 - 764 0 None D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3DA 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549K,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3DB 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 463 - 764 0 None N549K,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3DC 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 766 0 None N549K,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W3DD 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 463 - 765 0 None N549K,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W38A 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W38B 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W38C 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 465 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 8W38D 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2

Ligand: TZ0 (Futibatinib)

Total number of chains: 18
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 66.7% 8W3DA
DFGin BLAplus 3 16.7% 6MZWA
DFGin None 1 5.6% 6MZWB
DFGout None 1 5.6% 7D5OB
None None 1 5.6% 7D5OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR SRC SRC_CHICK 7D5OB 2.69 Inactive DFGout‑None out-out none-out TYR APEdihe_nniai APEdist_aaao TZ0 Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 7D5OA 2.69 Inactive None‑None out-out none-out TYR APEdihe_nniai APEdist_aaao TZ0 Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR FGFR1 FGFR1_HUMAN 6MZQA 2.0 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 464 - 765 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 6MZQB 2.0 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 462 - 761 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 6MZWA 2.2 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 464 - 765 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 6MZWB 2.2 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan TZ0 Type1.5_Back 463 - 762 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3BA 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3BB 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3BC 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3BD 2.23 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 465 - 764 0 None D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3DA 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549K,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3DB 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 463 - 764 0 None N549K,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3DC 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 766 0 None N549K,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W3DD 2.04 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 463 - 765 0 None N549K,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W38A 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W38B 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W38C 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 465 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 8W38D 2.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai TZ0 Type1.5_Back 467 - 764 0 None N549D,D650V Fibroblast growth factor receptor 2 Homo sapiens

Ligand: TZ0 (Futibatinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 1 50.0% 7D5OB
None None 1 50.0% 7D5OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR SRC SRC_CHICK 7D5OB 2.69 Inactive DFGout‑None out-out none-out TYR APEdihe_nniai APEdist_aaao TZ0 Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 7D5OA 2.69 Inactive None‑None out-out none-out TYR APEdihe_nniai APEdist_aaao TZ0 Type1 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus