KinCore

Ligand: TZ0 (Futibatinib)

Total number of chains: 16

Active chains: 0

Total number of genes: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	12	75.0%	8W3DA
DFGin	BLAplus	3	18.8%	6MZWA
DFGin	None	1	6.2%	6MZWB

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	FGFR1	FGFR1_HUMAN	6MZQA	P11362	464	765	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.0992	13.2584	BLAplus	-119.38, 163.65	62.35, 33.69	-91.12, -0.33	55.27, 84.16	-120.86, 13.76	in-in	in	7.9486	Saltbr-in	2.6775	HRD-in	-73.6, -55.96	80.43, -5.0	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -32.61	APE8-rot-na	334.89	APE67-dihe-in	-72.0, -8.25	-68.04, -26.27	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.0	0.196	0.23	A	311.0	277.0	24	30	12	18	[[478, 756]]	1.0	6mzq	TYR_FGFR1_HUMAN	TYR	1.5e-104	354.9	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR1	FGFR1_HUMAN	6MZQB	P11362	462	761	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.2291	13.0604	BLAplus	-109.43, 157.46	65.55, 34.29	-83.47, -21.73	59.11, 82.16	-85.45, 999.0	in-in	in	7.7832	Saltbr-in	2.8499	HRD-in	-69.06, -55.52	76.96, -3.46	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -39.35	APE8-rot-na	334.65	APE67-dihe-in	-70.64, -10.51	-51.58, -30.09	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.0	0.196	0.23	B	311.0	260.0	40	30	11	19	[[478, 756]]	1.0	6mzq	TYR_FGFR1_HUMAN	TYR	1.5e-104	354.9	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR1	FGFR1_HUMAN	6MZWA	P11362	464	765	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	4.8216	13.4005	BLAplus	-122.44, 164.99	57.07, 40.5	-90.84, 9.02	55.25, 82.2	-134.07, 2.85	in-in	in	8.0037	Saltbr-in	2.8192	HRD-in	-69.57, -56.52	83.74, -8.47	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -38.34	APE8-rot-na	329.11	APE67-dihe-in	-82.69, 5.42	-51.99, -31.29	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.2	0.244	0.297	A	311.0	282.0	20	30	12	18	[[478, 756]]	1.0	6mzw	TYR_FGFR1_HUMAN	TYR	2.1e-104	354.3	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR1	FGFR1_HUMAN	6MZWB	P11362	463	762	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.2433	13.1911	None	-113.61, 162.19	59.99, 41.93	-84.77, 999.0	49.28, 82.5	999.0, 999.0	in-in	in	7.816	Saltbr-in	2.6843	HRD-in	-70.89, -55.55	82.9, -7.56	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -23.86	APE8-rot-na	29.6	APE67-dihe-in	-68.26, -6.41	-48.51, -43.05	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.2	0.244	0.297	B	311.0	258.0	42	30	10	20	[[478, 756]]	1.0	6mzw	TYR_FGFR1_HUMAN	TYR	2.1e-104	354.3	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR2	FGFR2_HUMAN	8W3BA	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1613	13.7921	BLAminus	-144.89, -177.58	62.94, 96.35	-110.18, 24.57	301.57, 159.93	-61.44, -28.3	in-in	in	7.8656	Saltbr-in	2.9637	HRD-in	-87.0, -57.18	84.04, -4.97	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9448	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-110.51, 11.01	APE9-dihe-in	-96.95, 136.95	APE8-dihe-in	-62.98, 123.95	APE8-rot-na	335.72	APE67-dihe-in	-70.54, -2.64	-63.47, -42.68	APE12-dist-na	999.0	APE11-dist-na	10.859	APE10-dist-na	7.2237	APE9-dist-in	4.8167	D650V	None	None	XRAY	2.23	0.292	0.312	A	324.0	279.0	19	30	25	5	[[481, 759]]	1.0	8w3b	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3BB	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1803	13.8599	BLAminus	-144.53, -178.27	63.36, 96.56	-110.32, 24.83	301.28, 159.37	-61.06, -28.93	in-in	in	7.884	Saltbr-in	2.9651	HRD-in	-86.57, -57.01	84.08, -5.72	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9403	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-112.04, 13.83	APE9-dihe-in	-96.67, 136.92	APE8-dihe-in	-63.18, 124.36	APE8-rot-na	337.68	APE67-dihe-in	-70.88, -2.28	-62.39, -43.26	APE12-dist-na	999.0	APE11-dist-na	10.7439	APE10-dist-na	7.2302	APE9-dist-in	4.8211	D650V	None	None	XRAY	2.23	0.292	0.312	B	324.0	278.0	20	30	19	11	[[481, 759]]	1.0	8w3b	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3BC	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1305	13.8381	BLAminus	-145.32, -177.36	62.67, 96.38	-110.43, 24.64	301.15, 160.25	-61.18, -28.47	in-in	in	7.8261	Saltbr-in	2.9678	HRD-in	-87.03, -56.85	84.22, -5.5	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9413	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-112.46, 11.6	APE9-dihe-in	-97.28, 136.65	APE8-dihe-in	-63.45, 123.79	APE8-rot-na	336.35	APE67-dihe-in	-70.29, -2.36	-62.67, -42.99	APE12-dist-na	999.0	APE11-dist-na	10.8471	APE10-dist-na	7.2068	APE9-dist-in	4.8459	D650V	None	None	XRAY	2.23	0.292	0.312	C	324.0	294.0	4	30	26	4	[[481, 759]]	1.0	8w3b	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3BD	P21802	465	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1111	13.8671	BLAminus	-145.2, -177.75	62.8, 96.65	-110.44, 24.68	301.04, 159.7	-61.39, -28.62	in-in	in	7.8573	Saltbr-in	2.9615	HRD-in	-87.13, -57.13	84.17, -5.75	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9394	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-111.01, 12.17	APE9-dihe-in	-96.72, 136.82	APE8-dihe-in	-63.08, 124.37	APE8-rot-na	337.6	APE67-dihe-in	-71.49, -1.84	-62.33, -43.32	APE12-dist-na	999.0	APE11-dist-na	10.8169	APE10-dist-na	7.2349	APE9-dist-in	4.8288	D650V	None	None	XRAY	2.23	0.292	0.312	D	324.0	280.0	20	30	19	11	[[481, 759]]	1.0	8w3b	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DA	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8853	13.9149	BLAminus	-147.5, -176.54	60.37, 88.47	-102.26, 25.1	300.92, 154.4	-57.13, -34.04	in-in	in	7.8251	Saltbr-in	2.7968	HRD-in	-84.9, -54.51	77.26, 0.33	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8575	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-106.98, 12.82	APE9-dihe-in	-97.28, 131.96	APE8-dihe-in	-62.75, 115.5	APE8-rot-na	335.68	APE67-dihe-in	-74.05, -8.17	-56.13, -41.02	APE12-dist-na	10.0605	APE11-dist-na	11.1727	APE10-dist-na	7.3858	APE9-dist-in	4.9839	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	A	324.0	298.0	0	30	30	0	[[481, 759]]	1.0	8w3d	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DB	P21802	463	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8319	14.0174	BLAminus	-148.34, -176.74	60.99, 88.17	-102.41, 24.87	299.72, 154.97	-58.18, -33.84	in-in	in	7.7871	Saltbr-in	2.7649	HRD-in	-83.96, -54.88	76.41, -0.28	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8516	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-107.87, 19.37	APE9-dihe-in	-95.98, 132.29	APE8-dihe-in	-61.49, 116.39	APE8-rot-na	335.8	APE67-dihe-in	-74.83, -7.73	-55.74, -41.43	APE12-dist-na	10.8074	APE11-dist-na	10.9135	APE10-dist-na	7.4654	APE9-dist-in	4.9702	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	B	324.0	286.0	16	30	23	7	[[481, 759]]	1.0	8w3d	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DC	P21802	467	766	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8552	13.9002	BLAminus	-147.64, -176.09	60.07, 88.49	-102.13, 25.05	300.63, 154.01	-57.64, -33.63	in-in	in	7.7725	Saltbr-in	2.7934	HRD-in	-84.16, -54.95	77.08, 0.92	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8542	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-106.76, 14.01	APE9-dihe-in	-96.42, 131.36	APE8-dihe-in	-63.38, 115.02	APE8-rot-na	334.88	APE67-dihe-in	-73.92, -8.44	-56.07, -40.69	APE12-dist-na	10.1128	APE11-dist-na	11.132	APE10-dist-na	7.4256	APE9-dist-in	4.9863	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	C	324.0	300.0	0	30	30	0	[[481, 759]]	1.0	8w3d	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DD	P21802	463	765	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8116	14.007	BLAminus	-147.99, -176.89	61.0, 88.35	-102.2, 24.75	299.43, 154.83	-57.77, -34.3	in-in	in	7.7731	Saltbr-in	2.7585	HRD-in	-84.08, -54.96	76.09, 0.5	in-in-out	SNCiio	in-out	ActLoopNT-in	2.846	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-108.21, 21.5	APE9-dihe-in	-95.42, 132.82	APE8-dihe-in	-60.81, 115.91	APE8-rot-na	335.81	APE67-dihe-in	-74.61, -8.25	-55.74, -40.98	APE12-dist-na	10.7994	APE11-dist-na	10.9249	APE10-dist-na	7.5894	APE9-dist-in	4.9671	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	D	324.0	296.0	7	30	28	2	[[481, 759]]	1.0	8w3d	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38A	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.884	13.9387	BLAminus	-141.73, -172.44	58.43, 85.09	-99.65, 33.03	296.5, 153.04	-60.44, -42.96	in-in	in	7.7157	Saltbr-in	2.7302	HRD-in	-67.46, -57.27	77.66, 6.76	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8529	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-102.69, 6.19	APE9-dihe-in	-92.48, 138.52	APE8-dihe-in	-67.31, 130.89	APE8-rot-na	342.55	APE67-dihe-in	-76.49, 2.73	-63.26, -44.89	APE12-dist-na	9.9384	APE11-dist-na	10.8626	APE10-dist-na	7.1874	APE9-dist-in	4.84	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	A	324.0	298.0	0	30	30	0	[[481, 759]]	1.0	8w38	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38B	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.9169	13.8673	BLAminus	-141.61, -172.11	58.71, 84.88	-99.53, 33.01	296.86, 151.72	-60.67, -42.8	in-in	in	7.6773	Saltbr-in	2.7365	HRD-in	-66.89, -57.79	77.67, 7.38	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8537	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-102.73, 7.76	APE9-dihe-in	-92.14, 138.79	APE8-dihe-in	-66.97, 130.73	APE8-rot-na	341.51	APE67-dihe-in	-76.67, 2.98	-63.37, -44.91	APE12-dist-na	9.7659	APE11-dist-na	10.7509	APE10-dist-na	7.1935	APE9-dist-in	4.8257	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	B	324.0	288.0	10	30	24	6	[[481, 759]]	1.0	8w38	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38C	P21802	465	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.9054	14.0005	BLAminus	-141.73, -172.23	58.36, 85.55	-99.69, 32.51	297.47, 150.87	-60.14, -43.03	in-in	in	7.7655	Saltbr-in	2.7334	HRD-in	-67.3, -57.38	78.5, 5.79	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8526	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-100.74, 8.72	APE9-dihe-in	-90.56, 139.47	APE8-dihe-in	-66.09, 130.7	APE8-rot-na	342.51	APE67-dihe-in	-75.82, 2.85	-65.85, -41.6	APE12-dist-na	999.0	APE11-dist-na	10.6496	APE10-dist-na	7.2376	APE9-dist-in	4.7764	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	C	324.0	289.0	11	30	19	11	[[481, 759]]	1.0	8w38	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38D	P21802	467	764	821.0	TZ0:800	Type1.5_Back	Inactive	DFGin	5.9583	13.994	BLAminus	-141.63, -172.13	58.59, 85.21	-99.57, 33.16	297.38, 150.22	-60.22, -43.6	in-in	in	7.7819	Saltbr-in	2.7642	HRD-in	-66.88, -57.89	78.41, 5.63	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8509	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-100.9, 7.03	APE9-dihe-in	-91.06, 139.7	APE8-dihe-in	-66.27, 130.75	APE8-rot-na	343.36	APE67-dihe-in	-75.84, 2.91	-65.4, -41.85	APE12-dist-na	999.0	APE11-dist-na	10.7499	APE10-dist-na	7.2202	APE9-dist-in	4.7939	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	D	324.0	271.0	27	30	19	11	[[481, 759]]	1.0	8w38	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2

Ligand: TZ0 (Futibatinib)

Total number of chains: 18

Active chains: 0

Total number of genes: 3

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	12	66.7%	8W3DA
DFGin	BLAplus	3	16.7%	6MZWA
DFGin	None	1	5.6%	6MZWB
DFGout	None	1	5.6%	7D5OB
None	None	1	5.6%	7D5OA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	SRC	SRC_CHICK	7D5OB	P00523	258	533	533.0	TZ0:601	Type1	Inactive	DFGout	13.3663	8.4426	None	-133.05, 151.35	-120.2, 100.81	-97.25, 999.0	281.29, 106.01	999.0, 999.0	out-out	out	10.9217	Saltbr-out	8.7945	HRD-in	-93.35, -47.05	73.38, -4.37	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nniai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 63.47	APE8-dihe-in	-96.86, 65.04	APE8-rot-na	25.36	APE67-dihe-in	-67.37, -19.16	-67.49, -34.47	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	9.3386	None	None	None	XRAY	2.69	0.184	0.237	B	286.0	247.0	29	29	11	18	[[267, 518]]	1.0	7d5o	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1.0	260.0	260.0	403	404	405	407	409	295	310	314	383	385	384	386.0	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src
TYR	SRC	SRC_CHICK	7D5OA	P00523	257	533	533.0	TZ0:601	Type1	Inactive	None	999.0	999.0	None	-137.93, 166.12	-157.88, 999.0	999.0, 999.0	999.0, 999.0	999.0, 999.0	out-out	out	13.9732	Saltbr-out	13.6705	HRD-in	-88.58, -41.09	78.21, -16.51	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nniai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 123.61	APE8-dihe-in	-81.61, 67.63	APE8-rot-na	8.31	APE67-dihe-in	-62.1, -28.74	-68.36, -36.32	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	8.927	None	None	None	XRAY	2.69	0.184	0.237	A	286.0	254.0	23	29	10	19	[[267, 518]]	1.0	7d5o	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1.0	260.0	260.0	403	404	405	407	409	295	310	314	383	385	384	386.0	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src
TYR	FGFR1	FGFR1_HUMAN	6MZQA	P11362	464	765	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.0992	13.2584	BLAplus	-119.38, 163.65	62.35, 33.69	-91.12, -0.33	55.27, 84.16	-120.86, 13.76	in-in	in	7.9486	Saltbr-in	2.6775	HRD-in	-73.6, -55.96	80.43, -5.0	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -32.61	APE8-rot-na	334.89	APE67-dihe-in	-72.0, -8.25	-68.04, -26.27	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.0	0.196	0.23	A	311.0	277.0	24	30	12	18	[[478, 756]]	1.0	6mzq	Homo sapiens	TYR_FGFR1_HUMAN	TYR	1.5e-104	354.9	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR1	FGFR1_HUMAN	6MZQB	P11362	462	761	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.2291	13.0604	BLAplus	-109.43, 157.46	65.55, 34.29	-83.47, -21.73	59.11, 82.16	-85.45, 999.0	in-in	in	7.7832	Saltbr-in	2.8499	HRD-in	-69.06, -55.52	76.96, -3.46	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -39.35	APE8-rot-na	334.65	APE67-dihe-in	-70.64, -10.51	-51.58, -30.09	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.0	0.196	0.23	B	311.0	260.0	40	30	11	19	[[478, 756]]	1.0	6mzq	Homo sapiens	TYR_FGFR1_HUMAN	TYR	1.5e-104	354.9	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR1	FGFR1_HUMAN	6MZWA	P11362	464	765	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	4.8216	13.4005	BLAplus	-122.44, 164.99	57.07, 40.5	-90.84, 9.02	55.25, 82.2	-134.07, 2.85	in-in	in	8.0037	Saltbr-in	2.8192	HRD-in	-69.57, -56.52	83.74, -8.47	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -38.34	APE8-rot-na	329.11	APE67-dihe-in	-82.69, 5.42	-51.99, -31.29	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.2	0.244	0.297	A	311.0	282.0	20	30	12	18	[[478, 756]]	1.0	6mzw	Homo sapiens	TYR_FGFR1_HUMAN	TYR	2.1e-104	354.3	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR1	FGFR1_HUMAN	6MZWB	P11362	463	762	822.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.2433	13.1911	None	-113.61, 162.19	59.99, 41.93	-84.77, 999.0	49.28, 82.5	999.0, 999.0	in-in	in	7.816	Saltbr-in	2.6843	HRD-in	-70.89, -55.55	82.9, -7.56	in-none-none	SNCinn	none-none	ActLoopNT-none	999.0	ActLoopCT-none	TYR	APEdihe_nnnai	APEdist_aaan	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 999.0	APE8-dihe-none	999.0, -23.86	APE8-rot-na	29.6	APE67-dihe-in	-68.26, -6.41	-48.51, -43.05	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.2	0.244	0.297	B	311.0	258.0	42	30	10	20	[[478, 756]]	1.0	6mzw	Homo sapiens	TYR_FGFR1_HUMAN	TYR	2.1e-104	354.3	1.0	260.0	260.0	640	641	642	644	646	514	531	535	620	622	621	623.0	682	670	665	664	663	662	661	660	659	562	Fibroblast growth factor receptor 1
TYR	FGFR2	FGFR2_HUMAN	8W3BA	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1613	13.7921	BLAminus	-144.89, -177.58	62.94, 96.35	-110.18, 24.57	301.57, 159.93	-61.44, -28.3	in-in	in	7.8656	Saltbr-in	2.9637	HRD-in	-87.0, -57.18	84.04, -4.97	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9448	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-110.51, 11.01	APE9-dihe-in	-96.95, 136.95	APE8-dihe-in	-62.98, 123.95	APE8-rot-na	335.72	APE67-dihe-in	-70.54, -2.64	-63.47, -42.68	APE12-dist-na	999.0	APE11-dist-na	10.859	APE10-dist-na	7.2237	APE9-dist-in	4.8167	D650V	None	None	XRAY	2.23	0.292	0.312	A	324.0	279.0	19	30	25	5	[[481, 759]]	1.0	8w3b	Homo sapiens	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3BB	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1803	13.8599	BLAminus	-144.53, -178.27	63.36, 96.56	-110.32, 24.83	301.28, 159.37	-61.06, -28.93	in-in	in	7.884	Saltbr-in	2.9651	HRD-in	-86.57, -57.01	84.08, -5.72	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9403	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-112.04, 13.83	APE9-dihe-in	-96.67, 136.92	APE8-dihe-in	-63.18, 124.36	APE8-rot-na	337.68	APE67-dihe-in	-70.88, -2.28	-62.39, -43.26	APE12-dist-na	999.0	APE11-dist-na	10.7439	APE10-dist-na	7.2302	APE9-dist-in	4.8211	D650V	None	None	XRAY	2.23	0.292	0.312	B	324.0	278.0	20	30	19	11	[[481, 759]]	1.0	8w3b	Homo sapiens	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3BC	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1305	13.8381	BLAminus	-145.32, -177.36	62.67, 96.38	-110.43, 24.64	301.15, 160.25	-61.18, -28.47	in-in	in	7.8261	Saltbr-in	2.9678	HRD-in	-87.03, -56.85	84.22, -5.5	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9413	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-112.46, 11.6	APE9-dihe-in	-97.28, 136.65	APE8-dihe-in	-63.45, 123.79	APE8-rot-na	336.35	APE67-dihe-in	-70.29, -2.36	-62.67, -42.99	APE12-dist-na	999.0	APE11-dist-na	10.8471	APE10-dist-na	7.2068	APE9-dist-in	4.8459	D650V	None	None	XRAY	2.23	0.292	0.312	C	324.0	294.0	4	30	26	4	[[481, 759]]	1.0	8w3b	Homo sapiens	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3BD	P21802	465	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	6.1111	13.8671	BLAminus	-145.2, -177.75	62.8, 96.65	-110.44, 24.68	301.04, 159.7	-61.39, -28.62	in-in	in	7.8573	Saltbr-in	2.9615	HRD-in	-87.13, -57.13	84.17, -5.75	in-in-out	SNCiio	in-out	ActLoopNT-in	2.9394	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-111.01, 12.17	APE9-dihe-in	-96.72, 136.82	APE8-dihe-in	-63.08, 124.37	APE8-rot-na	337.6	APE67-dihe-in	-71.49, -1.84	-62.33, -43.32	APE12-dist-na	999.0	APE11-dist-na	10.8169	APE10-dist-na	7.2349	APE9-dist-in	4.8288	D650V	None	None	XRAY	2.23	0.292	0.312	D	324.0	280.0	20	30	19	11	[[481, 759]]	1.0	8w3b	Homo sapiens	TYR_FGFR2_HUMAN	TYR	9.8e-104	352.2	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DA	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8853	13.9149	BLAminus	-147.5, -176.54	60.37, 88.47	-102.26, 25.1	300.92, 154.4	-57.13, -34.04	in-in	in	7.8251	Saltbr-in	2.7968	HRD-in	-84.9, -54.51	77.26, 0.33	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8575	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-106.98, 12.82	APE9-dihe-in	-97.28, 131.96	APE8-dihe-in	-62.75, 115.5	APE8-rot-na	335.68	APE67-dihe-in	-74.05, -8.17	-56.13, -41.02	APE12-dist-na	10.0605	APE11-dist-na	11.1727	APE10-dist-na	7.3858	APE9-dist-in	4.9839	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	A	324.0	298.0	0	30	30	0	[[481, 759]]	1.0	8w3d	Homo sapiens	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DB	P21802	463	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8319	14.0174	BLAminus	-148.34, -176.74	60.99, 88.17	-102.41, 24.87	299.72, 154.97	-58.18, -33.84	in-in	in	7.7871	Saltbr-in	2.7649	HRD-in	-83.96, -54.88	76.41, -0.28	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8516	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-107.87, 19.37	APE9-dihe-in	-95.98, 132.29	APE8-dihe-in	-61.49, 116.39	APE8-rot-na	335.8	APE67-dihe-in	-74.83, -7.73	-55.74, -41.43	APE12-dist-na	10.8074	APE11-dist-na	10.9135	APE10-dist-na	7.4654	APE9-dist-in	4.9702	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	B	324.0	286.0	16	30	23	7	[[481, 759]]	1.0	8w3d	Homo sapiens	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DC	P21802	467	766	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8552	13.9002	BLAminus	-147.64, -176.09	60.07, 88.49	-102.13, 25.05	300.63, 154.01	-57.64, -33.63	in-in	in	7.7725	Saltbr-in	2.7934	HRD-in	-84.16, -54.95	77.08, 0.92	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8542	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-106.76, 14.01	APE9-dihe-in	-96.42, 131.36	APE8-dihe-in	-63.38, 115.02	APE8-rot-na	334.88	APE67-dihe-in	-73.92, -8.44	-56.07, -40.69	APE12-dist-na	10.1128	APE11-dist-na	11.132	APE10-dist-na	7.4256	APE9-dist-in	4.9863	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	C	324.0	300.0	0	30	30	0	[[481, 759]]	1.0	8w3d	Homo sapiens	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W3DD	P21802	463	765	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.8116	14.007	BLAminus	-147.99, -176.89	61.0, 88.35	-102.2, 24.75	299.43, 154.83	-57.77, -34.3	in-in	in	7.7731	Saltbr-in	2.7585	HRD-in	-84.08, -54.96	76.09, 0.5	in-in-out	SNCiio	in-out	ActLoopNT-in	2.846	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-108.21, 21.5	APE9-dihe-in	-95.42, 132.82	APE8-dihe-in	-60.81, 115.91	APE8-rot-na	335.81	APE67-dihe-in	-74.61, -8.25	-55.74, -40.98	APE12-dist-na	10.7994	APE11-dist-na	10.9249	APE10-dist-na	7.5894	APE9-dist-in	4.9671	N549K,D650V	None	None	XRAY	2.04	0.22	0.25	D	324.0	296.0	7	30	28	2	[[481, 759]]	1.0	8w3d	Homo sapiens	TYR_FGFR2_HUMAN	TYR	6.7e-104	352.7	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38A	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.884	13.9387	BLAminus	-141.73, -172.44	58.43, 85.09	-99.65, 33.03	296.5, 153.04	-60.44, -42.96	in-in	in	7.7157	Saltbr-in	2.7302	HRD-in	-67.46, -57.27	77.66, 6.76	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8529	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-102.69, 6.19	APE9-dihe-in	-92.48, 138.52	APE8-dihe-in	-67.31, 130.89	APE8-rot-na	342.55	APE67-dihe-in	-76.49, 2.73	-63.26, -44.89	APE12-dist-na	9.9384	APE11-dist-na	10.8626	APE10-dist-na	7.1874	APE9-dist-in	4.84	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	A	324.0	298.0	0	30	30	0	[[481, 759]]	1.0	8w38	Homo sapiens	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38B	P21802	467	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.9169	13.8673	BLAminus	-141.61, -172.11	58.71, 84.88	-99.53, 33.01	296.86, 151.72	-60.67, -42.8	in-in	in	7.6773	Saltbr-in	2.7365	HRD-in	-66.89, -57.79	77.67, 7.38	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8537	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-102.73, 7.76	APE9-dihe-in	-92.14, 138.79	APE8-dihe-in	-66.97, 130.73	APE8-rot-na	341.51	APE67-dihe-in	-76.67, 2.98	-63.37, -44.91	APE12-dist-na	9.7659	APE11-dist-na	10.7509	APE10-dist-na	7.1935	APE9-dist-in	4.8257	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	B	324.0	288.0	10	30	24	6	[[481, 759]]	1.0	8w38	Homo sapiens	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38C	P21802	465	764	821.0	TZ0:801	Type1.5_Back	Inactive	DFGin	5.9054	14.0005	BLAminus	-141.73, -172.23	58.36, 85.55	-99.69, 32.51	297.47, 150.87	-60.14, -43.03	in-in	in	7.7655	Saltbr-in	2.7334	HRD-in	-67.3, -57.38	78.5, 5.79	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8526	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-100.74, 8.72	APE9-dihe-in	-90.56, 139.47	APE8-dihe-in	-66.09, 130.7	APE8-rot-na	342.51	APE67-dihe-in	-75.82, 2.85	-65.85, -41.6	APE12-dist-na	999.0	APE11-dist-na	10.6496	APE10-dist-na	7.2376	APE9-dist-in	4.7764	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	C	324.0	289.0	11	30	19	11	[[481, 759]]	1.0	8w38	Homo sapiens	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2
TYR	FGFR2	FGFR2_HUMAN	8W38D	P21802	467	764	821.0	TZ0:800	Type1.5_Back	Inactive	DFGin	5.9583	13.994	BLAminus	-141.63, -172.13	58.59, 85.21	-99.57, 33.16	297.38, 150.22	-60.22, -43.6	in-in	in	7.7819	Saltbr-in	2.7642	HRD-in	-66.88, -57.89	78.41, 5.63	in-in-out	SNCiio	in-out	ActLoopNT-in	2.8509	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-100.9, 7.03	APE9-dihe-in	-91.06, 139.7	APE8-dihe-in	-66.27, 130.75	APE8-rot-na	343.36	APE67-dihe-in	-75.84, 2.91	-65.4, -41.85	APE12-dist-na	999.0	APE11-dist-na	10.7499	APE10-dist-na	7.2202	APE9-dist-in	4.7939	N549D,D650V	None	None	XRAY	2.6	0.337	0.359	D	324.0	271.0	27	30	19	11	[[481, 759]]	1.0	8w38	Homo sapiens	TYR_FGFR2_HUMAN	TYR	1.5e-103	351.6	1.0	260.0	260.0	643	644	645	647	649	517	534	538	623	625	624	626.0	685	673	668	667	666	665	664	663	662	565	Fibroblast growth factor receptor 2

Ligand: TZ0 (Futibatinib)

Total number of chains: 2

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGout	None	1	50.0%	7D5OB
None	None	1	50.0%	7D5OA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	SRC	SRC_CHICK	7D5OB	P00523	258	533	533.0	TZ0:601	Type1	Inactive	DFGout	13.3663	8.4426	None	-133.05, 151.35	-120.2, 100.81	-97.25, 999.0	281.29, 106.01	999.0, 999.0	out-out	out	10.9217	Saltbr-out	8.7945	HRD-in	-93.35, -47.05	73.38, -4.37	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nniai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 63.47	APE8-dihe-in	-96.86, 65.04	APE8-rot-na	25.36	APE67-dihe-in	-67.37, -19.16	-67.49, -34.47	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	9.3386	None	None	None	XRAY	2.69	0.184	0.237	B	286.0	247.0	29	29	11	18	[[267, 518]]	1.0	7d5o	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1.0	260.0	260.0	403	404	405	407	409	295	310	314	383	385	384	386.0	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src
TYR	SRC	SRC_CHICK	7D5OA	P00523	257	533	533.0	TZ0:601	Type1	Inactive	None	999.0	999.0	None	-137.93, 166.12	-157.88, 999.0	999.0, 999.0	999.0, 999.0	999.0, 999.0	out-out	out	13.9732	Saltbr-out	13.6705	HRD-in	-88.58, -41.09	78.21, -16.51	out-none-out	SNCono	none-out	ActLoopNT-none	999.0	ActLoopCT-out	TYR	APEdihe_nniai	APEdist_aaao	APE10-dihe-none	999.0, 999.0	APE9-dihe-none	999.0, 123.61	APE8-dihe-in	-81.61, 67.63	APE8-rot-na	8.31	APE67-dihe-in	-62.1, -28.74	-68.36, -36.32	APE12-dist-na	999.0	APE11-dist-na	999.0	APE10-dist-na	999.0	APE9-dist-out	8.927	None	None	None	XRAY	2.69	0.184	0.237	A	286.0	254.0	23	29	10	19	[[267, 518]]	1.0	7d5o	Gallus gallus	TYR_SRC_CHICK	TYR	3.4e-94	320.9	1.0	260.0	260.0	403	404	405	407	409	295	310	314	383	385	384	386.0	444	432	427	426	425	424	423	422	421	339	Proto-oncogene tyrosine-protein kinase Src