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| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | FGFR1 | FGFR1_HUMAN | 6MZQA | P11362 | 464 | 765 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.099 | 13.258 | BLAplus | -119.38, 163.65 | 62.35, 33.69 | -91.12, -0.33 | 55.27, 84.16 | -120.86, 13.76 | in-in | in | 7.949 | Saltbr-in | 2.678 | HRD-in | -73.6, -55.96 | 80.43, -5.0 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -32.61 | APE8-rot-na | 334.89 | APE67-dihe-in | -72.0, -8.25 | -68.04, -26.27 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.0 | 0.196 | 0.23 | A | 311 | 277 | 24 | 0 | 0 | 18 | [[478, 756]] | 1.0 | 6mzq | TYR_FGFR1_HUMAN | TYR | 1.5e-104 | 354.9 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZQB | P11362 | 462 | 761 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.229 | 13.06 | BLAplus | -109.43, 157.46 | 65.55, 34.29 | -83.47, -21.73 | 59.11, 82.16 | -85.45, 999.0 | in-in | in | 7.783 | Saltbr-in | 2.85 | HRD-in | -69.06, -55.52 | 76.96, -3.46 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -39.35 | APE8-rot-na | 334.65 | APE67-dihe-in | -70.64, -10.51 | -51.58, -30.09 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.0 | 0.196 | 0.23 | B | 311 | 260 | 40 | 0 | 0 | 19 | [[478, 756]] | 1.0 | 6mzq | TYR_FGFR1_HUMAN | TYR | 1.5e-104 | 354.9 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZWA | P11362 | 464 | 765 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 4.822 | 13.4 | BLAplus | -122.44, 164.99 | 57.07, 40.5 | -90.84, 9.02 | 55.25, 82.2 | -134.07, 2.85 | in-in | in | 8.004 | Saltbr-in | 2.819 | HRD-in | -69.57, -56.52 | 83.74, -8.47 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -38.34 | APE8-rot-na | 329.11 | APE67-dihe-in | -82.69, 5.42 | -51.99, -31.29 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.2 | 0.244 | 0.297 | A | 311 | 282 | 20 | 0 | 0 | 18 | [[478, 756]] | 1.0 | 6mzw | TYR_FGFR1_HUMAN | TYR | 2.1e-104 | 354.3 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZWB | P11362 | 463 | 762 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.243 | 13.191 | None | -113.61, 162.19 | 59.99, 41.93 | -84.77, 999.0 | 49.28, 82.5 | 999.0, 999.0 | in-in | in | 7.816 | Saltbr-in | 2.684 | HRD-in | -70.89, -55.55 | 82.9, -7.56 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -23.86 | APE8-rot-na | 29.6 | APE67-dihe-in | -68.26, -6.41 | -48.51, -43.05 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.2 | 0.244 | 0.297 | B | 311 | 258 | 42 | 0 | 0 | 20 | [[478, 756]] | 1.0 | 6mzw | TYR_FGFR1_HUMAN | TYR | 2.1e-104 | 354.3 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BA | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.161 | 13.792 | BLAminus | -144.89, -177.58 | 62.94, 96.35 | -110.18, 24.57 | 301.57, 159.93 | -61.44, -28.3 | in-in | in | 7.866 | Saltbr-in | 2.964 | HRD-in | -87.0, -57.18 | 84.04, -4.97 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.945 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -110.51, 11.01 | APE9-dihe-in | -96.95, 136.95 | APE8-dihe-in | -62.98, 123.95 | APE8-rot-na | 335.72 | APE67-dihe-in | -70.54, -2.64 | -63.47, -42.68 | APE12-dist-na | 999.0 | APE11-dist-na | 10.859 | APE10-dist-na | 7.224 | APE9-dist-in | 4.817 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | A | 324 | 279 | 19 | 0 | 0 | 5 | [[481, 759]] | 1.0 | 8w3b | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BB | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.18 | 13.86 | BLAminus | -144.53, -178.27 | 63.36, 96.56 | -110.32, 24.83 | 301.28, 159.37 | -61.06, -28.93 | in-in | in | 7.884 | Saltbr-in | 2.965 | HRD-in | -86.57, -57.01 | 84.08, -5.72 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.94 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -112.04, 13.83 | APE9-dihe-in | -96.67, 136.92 | APE8-dihe-in | -63.18, 124.36 | APE8-rot-na | 337.68 | APE67-dihe-in | -70.88, -2.28 | -62.39, -43.26 | APE12-dist-na | 999.0 | APE11-dist-na | 10.744 | APE10-dist-na | 7.23 | APE9-dist-in | 4.821 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | B | 324 | 278 | 20 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w3b | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BC | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.13 | 13.838 | BLAminus | -145.32, -177.36 | 62.67, 96.38 | -110.43, 24.64 | 301.15, 160.25 | -61.18, -28.47 | in-in | in | 7.826 | Saltbr-in | 2.968 | HRD-in | -87.03, -56.85 | 84.22, -5.5 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.941 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -112.46, 11.6 | APE9-dihe-in | -97.28, 136.65 | APE8-dihe-in | -63.45, 123.79 | APE8-rot-na | 336.35 | APE67-dihe-in | -70.29, -2.36 | -62.67, -42.99 | APE12-dist-na | 999.0 | APE11-dist-na | 10.847 | APE10-dist-na | 7.207 | APE9-dist-in | 4.846 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | C | 324 | 294 | 4 | 0 | 0 | 4 | [[481, 759]] | 1.0 | 8w3b | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BD | P21802 | 465 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.111 | 13.867 | BLAminus | -145.2, -177.75 | 62.8, 96.65 | -110.44, 24.68 | 301.04, 159.7 | -61.39, -28.62 | in-in | in | 7.857 | Saltbr-in | 2.962 | HRD-in | -87.13, -57.13 | 84.17, -5.75 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.939 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -111.01, 12.17 | APE9-dihe-in | -96.72, 136.82 | APE8-dihe-in | -63.08, 124.37 | APE8-rot-na | 337.6 | APE67-dihe-in | -71.49, -1.84 | -62.33, -43.32 | APE12-dist-na | 999.0 | APE11-dist-na | 10.817 | APE10-dist-na | 7.235 | APE9-dist-in | 4.829 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | D | 324 | 280 | 20 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w3b | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DA | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.885 | 13.915 | BLAminus | -147.5, -176.54 | 60.37, 88.47 | -102.26, 25.1 | 300.92, 154.4 | -57.13, -34.04 | in-in | in | 7.825 | Saltbr-in | 2.797 | HRD-in | -84.9, -54.51 | 77.26, 0.33 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.857 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -106.98, 12.82 | APE9-dihe-in | -97.28, 131.96 | APE8-dihe-in | -62.75, 115.5 | APE8-rot-na | 335.68 | APE67-dihe-in | -74.05, -8.17 | -56.13, -41.02 | APE12-dist-na | 10.06 | APE11-dist-na | 11.173 | APE10-dist-na | 7.386 | APE9-dist-in | 4.984 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | A | 324 | 298 | 0 | 0 | 0 | 0 | [[481, 759]] | 1.0 | 8w3d | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DB | P21802 | 463 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.832 | 14.017 | BLAminus | -148.34, -176.74 | 60.99, 88.17 | -102.41, 24.87 | 299.72, 154.97 | -58.18, -33.84 | in-in | in | 7.787 | Saltbr-in | 2.765 | HRD-in | -83.96, -54.88 | 76.41, -0.28 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.852 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -107.87, 19.37 | APE9-dihe-in | -95.98, 132.29 | APE8-dihe-in | -61.49, 116.39 | APE8-rot-na | 335.8 | APE67-dihe-in | -74.83, -7.73 | -55.74, -41.43 | APE12-dist-na | 10.807 | APE11-dist-na | 10.914 | APE10-dist-na | 7.465 | APE9-dist-in | 4.97 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | B | 324 | 286 | 16 | 0 | 0 | 7 | [[481, 759]] | 1.0 | 8w3d | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DC | P21802 | 467 | 766 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.855 | 13.9 | BLAminus | -147.64, -176.09 | 60.07, 88.49 | -102.13, 25.05 | 300.63, 154.01 | -57.64, -33.63 | in-in | in | 7.772 | Saltbr-in | 2.793 | HRD-in | -84.16, -54.95 | 77.08, 0.92 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.854 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -106.76, 14.01 | APE9-dihe-in | -96.42, 131.36 | APE8-dihe-in | -63.38, 115.02 | APE8-rot-na | 334.88 | APE67-dihe-in | -73.92, -8.44 | -56.07, -40.69 | APE12-dist-na | 10.113 | APE11-dist-na | 11.132 | APE10-dist-na | 7.426 | APE9-dist-in | 4.986 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | C | 324 | 300 | 0 | 0 | 0 | 0 | [[481, 759]] | 1.0 | 8w3d | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DD | P21802 | 463 | 765 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.812 | 14.007 | BLAminus | -147.99, -176.89 | 61.0, 88.35 | -102.2, 24.75 | 299.43, 154.83 | -57.77, -34.3 | in-in | in | 7.773 | Saltbr-in | 2.759 | HRD-in | -84.08, -54.96 | 76.09, 0.5 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.846 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -108.21, 21.5 | APE9-dihe-in | -95.42, 132.82 | APE8-dihe-in | -60.81, 115.91 | APE8-rot-na | 335.81 | APE67-dihe-in | -74.61, -8.25 | -55.74, -40.98 | APE12-dist-na | 10.799 | APE11-dist-na | 10.925 | APE10-dist-na | 7.589 | APE9-dist-in | 4.967 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | D | 324 | 296 | 7 | 0 | 0 | 2 | [[481, 759]] | 1.0 | 8w3d | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38A | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.884 | 13.939 | BLAminus | -141.73, -172.44 | 58.43, 85.09 | -99.65, 33.03 | 296.5, 153.04 | -60.44, -42.96 | in-in | in | 7.716 | Saltbr-in | 2.73 | HRD-in | -67.46, -57.27 | 77.66, 6.76 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.853 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -102.69, 6.19 | APE9-dihe-in | -92.48, 138.52 | APE8-dihe-in | -67.31, 130.89 | APE8-rot-na | 342.55 | APE67-dihe-in | -76.49, 2.73 | -63.26, -44.89 | APE12-dist-na | 9.938 | APE11-dist-na | 10.863 | APE10-dist-na | 7.187 | APE9-dist-in | 4.84 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | A | 324 | 298 | 0 | 0 | 0 | 0 | [[481, 759]] | 1.0 | 8w38 | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38B | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.917 | 13.867 | BLAminus | -141.61, -172.11 | 58.71, 84.88 | -99.53, 33.01 | 296.86, 151.72 | -60.67, -42.8 | in-in | in | 7.677 | Saltbr-in | 2.736 | HRD-in | -66.89, -57.79 | 77.67, 7.38 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.854 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -102.73, 7.76 | APE9-dihe-in | -92.14, 138.79 | APE8-dihe-in | -66.97, 130.73 | APE8-rot-na | 341.51 | APE67-dihe-in | -76.67, 2.98 | -63.37, -44.91 | APE12-dist-na | 9.766 | APE11-dist-na | 10.751 | APE10-dist-na | 7.194 | APE9-dist-in | 4.826 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | B | 324 | 288 | 10 | 0 | 0 | 6 | [[481, 759]] | 1.0 | 8w38 | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38C | P21802 | 465 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.905 | 14.001 | BLAminus | -141.73, -172.23 | 58.36, 85.55 | -99.69, 32.51 | 297.47, 150.87 | -60.14, -43.03 | in-in | in | 7.766 | Saltbr-in | 2.733 | HRD-in | -67.3, -57.38 | 78.5, 5.79 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.853 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -100.74, 8.72 | APE9-dihe-in | -90.56, 139.47 | APE8-dihe-in | -66.09, 130.7 | APE8-rot-na | 342.51 | APE67-dihe-in | -75.82, 2.85 | -65.85, -41.6 | APE12-dist-na | 999.0 | APE11-dist-na | 10.65 | APE10-dist-na | 7.238 | APE9-dist-in | 4.776 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | C | 324 | 289 | 11 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w38 | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38D | P21802 | 467 | 764 | 821.0 | TZ0:800 | Type1.5_Back | Inactive | DFGin | 5.958 | 13.994 | BLAminus | -141.63, -172.13 | 58.59, 85.21 | -99.57, 33.16 | 297.38, 150.22 | -60.22, -43.6 | in-in | in | 7.782 | Saltbr-in | 2.764 | HRD-in | -66.88, -57.89 | 78.41, 5.63 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.851 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -100.9, 7.03 | APE9-dihe-in | -91.06, 139.7 | APE8-dihe-in | -66.27, 130.75 | APE8-rot-na | 343.36 | APE67-dihe-in | -75.84, 2.91 | -65.4, -41.85 | APE12-dist-na | 999.0 | APE11-dist-na | 10.75 | APE10-dist-na | 7.22 | APE9-dist-in | 4.794 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | D | 324 | 271 | 27 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w38 | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | SRC | SRC_CHICK | 7D5OB | P00523 | 258 | 533 | 533.0 | TZ0:601 | Type1 | Inactive | DFGout | 13.366 | 8.443 | None | -133.05, 151.35 | -120.2, 100.81 | -97.25, 999.0 | 281.29, 106.01 | 999.0, 999.0 | out-out | out | 10.922 | Saltbr-out | 8.794 | HRD-in | -93.35, -47.05 | 73.38, -4.37 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 63.47 | APE8-dihe-in | -96.86, 65.04 | APE8-rot-na | 25.36 | APE67-dihe-in | -67.37, -19.16 | -67.49, -34.47 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 9.339 | None | None | None | XRAY | 2.69 | 0.184 | 0.237 | B | 286 | 247 | 29 | 0 | 0 | 18 | [[267, 518]] | 1.0 | 7d5o | Gallus gallus | TYR_SRC_CHICK | TYR | 3.4e-94 | 320.9 | 1 | 260 | 260 | 403 | 404 | 405 | 407 | 409 | 295 | 310 | 314 | 383 | 385 | 384 | 386 | 444 | 432 | 427 | 426 | 425 | 424 | 423 | 422 | 421 | 339 | Proto-oncogene tyrosine-protein kinase Src |
| TYR | SRC | SRC_CHICK | 7D5OA | P00523 | 257 | 533 | 533.0 | TZ0:601 | Type1 | Inactive | None | 999.0 | 999.0 | None | -137.93, 166.12 | -157.88, 999.0 | 999.0, 999.0 | 999.0, 999.0 | 999.0, 999.0 | out-out | out | 13.973 | Saltbr-out | 13.671 | HRD-in | -88.58, -41.09 | 78.21, -16.51 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 123.61 | APE8-dihe-in | -81.61, 67.63 | APE8-rot-na | 8.31 | APE67-dihe-in | -62.1, -28.74 | -68.36, -36.32 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.927 | None | None | None | XRAY | 2.69 | 0.184 | 0.237 | A | 286 | 254 | 23 | 0 | 0 | 19 | [[267, 518]] | 1.0 | 7d5o | Gallus gallus | TYR_SRC_CHICK | TYR | 3.4e-94 | 320.9 | 1 | 260 | 260 | 403 | 404 | 405 | 407 | 409 | 295 | 310 | 314 | 383 | 385 | 384 | 386 | 444 | 432 | 427 | 426 | 425 | 424 | 423 | 422 | 421 | 339 | Proto-oncogene tyrosine-protein kinase Src |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZQA | P11362 | 464 | 765 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.099 | 13.258 | BLAplus | -119.38, 163.65 | 62.35, 33.69 | -91.12, -0.33 | 55.27, 84.16 | -120.86, 13.76 | in-in | in | 7.949 | Saltbr-in | 2.678 | HRD-in | -73.6, -55.96 | 80.43, -5.0 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -32.61 | APE8-rot-na | 334.89 | APE67-dihe-in | -72.0, -8.25 | -68.04, -26.27 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.0 | 0.196 | 0.23 | A | 311 | 277 | 24 | 0 | 0 | 18 | [[478, 756]] | 1.0 | 6mzq | Homo sapiens | TYR_FGFR1_HUMAN | TYR | 1.5e-104 | 354.9 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZQB | P11362 | 462 | 761 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.229 | 13.06 | BLAplus | -109.43, 157.46 | 65.55, 34.29 | -83.47, -21.73 | 59.11, 82.16 | -85.45, 999.0 | in-in | in | 7.783 | Saltbr-in | 2.85 | HRD-in | -69.06, -55.52 | 76.96, -3.46 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -39.35 | APE8-rot-na | 334.65 | APE67-dihe-in | -70.64, -10.51 | -51.58, -30.09 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.0 | 0.196 | 0.23 | B | 311 | 260 | 40 | 0 | 0 | 19 | [[478, 756]] | 1.0 | 6mzq | Homo sapiens | TYR_FGFR1_HUMAN | TYR | 1.5e-104 | 354.9 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZWA | P11362 | 464 | 765 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 4.822 | 13.4 | BLAplus | -122.44, 164.99 | 57.07, 40.5 | -90.84, 9.02 | 55.25, 82.2 | -134.07, 2.85 | in-in | in | 8.004 | Saltbr-in | 2.819 | HRD-in | -69.57, -56.52 | 83.74, -8.47 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -38.34 | APE8-rot-na | 329.11 | APE67-dihe-in | -82.69, 5.42 | -51.99, -31.29 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.2 | 0.244 | 0.297 | A | 311 | 282 | 20 | 0 | 0 | 18 | [[478, 756]] | 1.0 | 6mzw | Homo sapiens | TYR_FGFR1_HUMAN | TYR | 2.1e-104 | 354.3 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR1 | FGFR1_HUMAN | 6MZWB | P11362 | 463 | 762 | 822.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.243 | 13.191 | None | -113.61, 162.19 | 59.99, 41.93 | -84.77, 999.0 | 49.28, 82.5 | 999.0, 999.0 | in-in | in | 7.816 | Saltbr-in | 2.684 | HRD-in | -70.89, -55.55 | 82.9, -7.56 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, -23.86 | APE8-rot-na | 29.6 | APE67-dihe-in | -68.26, -6.41 | -48.51, -43.05 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.2 | 0.244 | 0.297 | B | 311 | 258 | 42 | 0 | 0 | 20 | [[478, 756]] | 1.0 | 6mzw | Homo sapiens | TYR_FGFR1_HUMAN | TYR | 2.1e-104 | 354.3 | 1 | 260 | 260 | 640 | 641 | 642 | 644 | 646 | 514 | 531 | 535 | 620 | 622 | 621 | 623 | 682 | 670 | 665 | 664 | 663 | 662 | 661 | 660 | 659 | 562 | Fibroblast growth factor receptor 1 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BA | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.161 | 13.792 | BLAminus | -144.89, -177.58 | 62.94, 96.35 | -110.18, 24.57 | 301.57, 159.93 | -61.44, -28.3 | in-in | in | 7.866 | Saltbr-in | 2.964 | HRD-in | -87.0, -57.18 | 84.04, -4.97 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.945 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -110.51, 11.01 | APE9-dihe-in | -96.95, 136.95 | APE8-dihe-in | -62.98, 123.95 | APE8-rot-na | 335.72 | APE67-dihe-in | -70.54, -2.64 | -63.47, -42.68 | APE12-dist-na | 999.0 | APE11-dist-na | 10.859 | APE10-dist-na | 7.224 | APE9-dist-in | 4.817 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | A | 324 | 279 | 19 | 0 | 0 | 5 | [[481, 759]] | 1.0 | 8w3b | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BB | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.18 | 13.86 | BLAminus | -144.53, -178.27 | 63.36, 96.56 | -110.32, 24.83 | 301.28, 159.37 | -61.06, -28.93 | in-in | in | 7.884 | Saltbr-in | 2.965 | HRD-in | -86.57, -57.01 | 84.08, -5.72 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.94 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -112.04, 13.83 | APE9-dihe-in | -96.67, 136.92 | APE8-dihe-in | -63.18, 124.36 | APE8-rot-na | 337.68 | APE67-dihe-in | -70.88, -2.28 | -62.39, -43.26 | APE12-dist-na | 999.0 | APE11-dist-na | 10.744 | APE10-dist-na | 7.23 | APE9-dist-in | 4.821 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | B | 324 | 278 | 20 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w3b | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BC | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.13 | 13.838 | BLAminus | -145.32, -177.36 | 62.67, 96.38 | -110.43, 24.64 | 301.15, 160.25 | -61.18, -28.47 | in-in | in | 7.826 | Saltbr-in | 2.968 | HRD-in | -87.03, -56.85 | 84.22, -5.5 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.941 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -112.46, 11.6 | APE9-dihe-in | -97.28, 136.65 | APE8-dihe-in | -63.45, 123.79 | APE8-rot-na | 336.35 | APE67-dihe-in | -70.29, -2.36 | -62.67, -42.99 | APE12-dist-na | 999.0 | APE11-dist-na | 10.847 | APE10-dist-na | 7.207 | APE9-dist-in | 4.846 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | C | 324 | 294 | 4 | 0 | 0 | 4 | [[481, 759]] | 1.0 | 8w3b | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3BD | P21802 | 465 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 6.111 | 13.867 | BLAminus | -145.2, -177.75 | 62.8, 96.65 | -110.44, 24.68 | 301.04, 159.7 | -61.39, -28.62 | in-in | in | 7.857 | Saltbr-in | 2.962 | HRD-in | -87.13, -57.13 | 84.17, -5.75 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.939 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -111.01, 12.17 | APE9-dihe-in | -96.72, 136.82 | APE8-dihe-in | -63.08, 124.37 | APE8-rot-na | 337.6 | APE67-dihe-in | -71.49, -1.84 | -62.33, -43.32 | APE12-dist-na | 999.0 | APE11-dist-na | 10.817 | APE10-dist-na | 7.235 | APE9-dist-in | 4.829 | D650V | None | None | XRAY | 2.23 | 0.292 | 0.312 | D | 324 | 280 | 20 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w3b | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 9.8e-104 | 352.2 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DA | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.885 | 13.915 | BLAminus | -147.5, -176.54 | 60.37, 88.47 | -102.26, 25.1 | 300.92, 154.4 | -57.13, -34.04 | in-in | in | 7.825 | Saltbr-in | 2.797 | HRD-in | -84.9, -54.51 | 77.26, 0.33 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.857 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -106.98, 12.82 | APE9-dihe-in | -97.28, 131.96 | APE8-dihe-in | -62.75, 115.5 | APE8-rot-na | 335.68 | APE67-dihe-in | -74.05, -8.17 | -56.13, -41.02 | APE12-dist-na | 10.06 | APE11-dist-na | 11.173 | APE10-dist-na | 7.386 | APE9-dist-in | 4.984 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | A | 324 | 298 | 0 | 0 | 0 | 0 | [[481, 759]] | 1.0 | 8w3d | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DB | P21802 | 463 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.832 | 14.017 | BLAminus | -148.34, -176.74 | 60.99, 88.17 | -102.41, 24.87 | 299.72, 154.97 | -58.18, -33.84 | in-in | in | 7.787 | Saltbr-in | 2.765 | HRD-in | -83.96, -54.88 | 76.41, -0.28 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.852 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -107.87, 19.37 | APE9-dihe-in | -95.98, 132.29 | APE8-dihe-in | -61.49, 116.39 | APE8-rot-na | 335.8 | APE67-dihe-in | -74.83, -7.73 | -55.74, -41.43 | APE12-dist-na | 10.807 | APE11-dist-na | 10.914 | APE10-dist-na | 7.465 | APE9-dist-in | 4.97 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | B | 324 | 286 | 16 | 0 | 0 | 7 | [[481, 759]] | 1.0 | 8w3d | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DC | P21802 | 467 | 766 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.855 | 13.9 | BLAminus | -147.64, -176.09 | 60.07, 88.49 | -102.13, 25.05 | 300.63, 154.01 | -57.64, -33.63 | in-in | in | 7.772 | Saltbr-in | 2.793 | HRD-in | -84.16, -54.95 | 77.08, 0.92 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.854 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -106.76, 14.01 | APE9-dihe-in | -96.42, 131.36 | APE8-dihe-in | -63.38, 115.02 | APE8-rot-na | 334.88 | APE67-dihe-in | -73.92, -8.44 | -56.07, -40.69 | APE12-dist-na | 10.113 | APE11-dist-na | 11.132 | APE10-dist-na | 7.426 | APE9-dist-in | 4.986 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | C | 324 | 300 | 0 | 0 | 0 | 0 | [[481, 759]] | 1.0 | 8w3d | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W3DD | P21802 | 463 | 765 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.812 | 14.007 | BLAminus | -147.99, -176.89 | 61.0, 88.35 | -102.2, 24.75 | 299.43, 154.83 | -57.77, -34.3 | in-in | in | 7.773 | Saltbr-in | 2.759 | HRD-in | -84.08, -54.96 | 76.09, 0.5 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.846 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -108.21, 21.5 | APE9-dihe-in | -95.42, 132.82 | APE8-dihe-in | -60.81, 115.91 | APE8-rot-na | 335.81 | APE67-dihe-in | -74.61, -8.25 | -55.74, -40.98 | APE12-dist-na | 10.799 | APE11-dist-na | 10.925 | APE10-dist-na | 7.589 | APE9-dist-in | 4.967 | N549K,D650V | None | None | XRAY | 2.04 | 0.22 | 0.25 | D | 324 | 296 | 7 | 0 | 0 | 2 | [[481, 759]] | 1.0 | 8w3d | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 6.7e-104 | 352.7 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38A | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.884 | 13.939 | BLAminus | -141.73, -172.44 | 58.43, 85.09 | -99.65, 33.03 | 296.5, 153.04 | -60.44, -42.96 | in-in | in | 7.716 | Saltbr-in | 2.73 | HRD-in | -67.46, -57.27 | 77.66, 6.76 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.853 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -102.69, 6.19 | APE9-dihe-in | -92.48, 138.52 | APE8-dihe-in | -67.31, 130.89 | APE8-rot-na | 342.55 | APE67-dihe-in | -76.49, 2.73 | -63.26, -44.89 | APE12-dist-na | 9.938 | APE11-dist-na | 10.863 | APE10-dist-na | 7.187 | APE9-dist-in | 4.84 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | A | 324 | 298 | 0 | 0 | 0 | 0 | [[481, 759]] | 1.0 | 8w38 | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38B | P21802 | 467 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.917 | 13.867 | BLAminus | -141.61, -172.11 | 58.71, 84.88 | -99.53, 33.01 | 296.86, 151.72 | -60.67, -42.8 | in-in | in | 7.677 | Saltbr-in | 2.736 | HRD-in | -66.89, -57.79 | 77.67, 7.38 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.854 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -102.73, 7.76 | APE9-dihe-in | -92.14, 138.79 | APE8-dihe-in | -66.97, 130.73 | APE8-rot-na | 341.51 | APE67-dihe-in | -76.67, 2.98 | -63.37, -44.91 | APE12-dist-na | 9.766 | APE11-dist-na | 10.751 | APE10-dist-na | 7.194 | APE9-dist-in | 4.826 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | B | 324 | 288 | 10 | 0 | 0 | 6 | [[481, 759]] | 1.0 | 8w38 | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38C | P21802 | 465 | 764 | 821.0 | TZ0:801 | Type1.5_Back | Inactive | DFGin | 5.905 | 14.001 | BLAminus | -141.73, -172.23 | 58.36, 85.55 | -99.69, 32.51 | 297.47, 150.87 | -60.14, -43.03 | in-in | in | 7.766 | Saltbr-in | 2.733 | HRD-in | -67.3, -57.38 | 78.5, 5.79 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.853 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -100.74, 8.72 | APE9-dihe-in | -90.56, 139.47 | APE8-dihe-in | -66.09, 130.7 | APE8-rot-na | 342.51 | APE67-dihe-in | -75.82, 2.85 | -65.85, -41.6 | APE12-dist-na | 999.0 | APE11-dist-na | 10.65 | APE10-dist-na | 7.238 | APE9-dist-in | 4.776 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | C | 324 | 289 | 11 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w38 | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
| TYR | FGFR2 | FGFR2_HUMAN | 8W38D | P21802 | 467 | 764 | 821.0 | TZ0:800 | Type1.5_Back | Inactive | DFGin | 5.958 | 13.994 | BLAminus | -141.63, -172.13 | 58.59, 85.21 | -99.57, 33.16 | 297.38, 150.22 | -60.22, -43.6 | in-in | in | 7.782 | Saltbr-in | 2.764 | HRD-in | -66.88, -57.89 | 78.41, 5.63 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.851 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -100.9, 7.03 | APE9-dihe-in | -91.06, 139.7 | APE8-dihe-in | -66.27, 130.75 | APE8-rot-na | 343.36 | APE67-dihe-in | -75.84, 2.91 | -65.4, -41.85 | APE12-dist-na | 999.0 | APE11-dist-na | 10.75 | APE10-dist-na | 7.22 | APE9-dist-in | 4.794 | N549D,D650V | None | None | XRAY | 2.6 | 0.337 | 0.359 | D | 324 | 271 | 27 | 0 | 0 | 11 | [[481, 759]] | 1.0 | 8w38 | Homo sapiens | TYR_FGFR2_HUMAN | TYR | 1.5e-103 | 351.6 | 1 | 260 | 260 | 643 | 644 | 645 | 647 | 649 | 517 | 534 | 538 | 623 | 625 | 624 | 626 | 685 | 673 | 668 | 667 | 666 | 665 | 664 | 663 | 662 | 565 | Fibroblast growth factor receptor 2 |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | SRC | SRC_CHICK | 7D5OB | P00523 | 258 | 533 | 533.0 | TZ0:601 | Type1 | Inactive | DFGout | 13.366 | 8.443 | None | -133.05, 151.35 | -120.2, 100.81 | -97.25, 999.0 | 281.29, 106.01 | 999.0, 999.0 | out-out | out | 10.922 | Saltbr-out | 8.794 | HRD-in | -93.35, -47.05 | 73.38, -4.37 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 63.47 | APE8-dihe-in | -96.86, 65.04 | APE8-rot-na | 25.36 | APE67-dihe-in | -67.37, -19.16 | -67.49, -34.47 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 9.339 | None | None | None | XRAY | 2.69 | 0.184 | 0.237 | B | 286 | 247 | 29 | 0 | 0 | 18 | [[267, 518]] | 1.0 | 7d5o | Gallus gallus | TYR_SRC_CHICK | TYR | 3.4e-94 | 320.9 | 1 | 260 | 260 | 403 | 404 | 405 | 407 | 409 | 295 | 310 | 314 | 383 | 385 | 384 | 386 | 444 | 432 | 427 | 426 | 425 | 424 | 423 | 422 | 421 | 339 | Proto-oncogene tyrosine-protein kinase Src |
| TYR | SRC | SRC_CHICK | 7D5OA | P00523 | 257 | 533 | 533.0 | TZ0:601 | Type1 | Inactive | None | 999.0 | 999.0 | None | -137.93, 166.12 | -157.88, 999.0 | 999.0, 999.0 | 999.0, 999.0 | 999.0, 999.0 | out-out | out | 13.973 | Saltbr-out | 13.671 | HRD-in | -88.58, -41.09 | 78.21, -16.51 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 123.61 | APE8-dihe-in | -81.61, 67.63 | APE8-rot-na | 8.31 | APE67-dihe-in | -62.1, -28.74 | -68.36, -36.32 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.927 | None | None | None | XRAY | 2.69 | 0.184 | 0.237 | A | 286 | 254 | 23 | 0 | 0 | 19 | [[267, 518]] | 1.0 | 7d5o | Gallus gallus | TYR_SRC_CHICK | TYR | 3.4e-94 | 320.9 | 1 | 260 | 260 | 403 | 404 | 405 | 407 | 409 | 295 | 310 | 314 | 383 | 385 | 384 | 386 | 444 | 432 | 427 | 426 | 425 | 424 | 423 | 422 | 421 | 339 | Proto-oncogene tyrosine-protein kinase Src |