Ligand: SKE

Total number of chains: 13
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 46.2% 4QMUA
DFGin ABAminus 3 23.1% 5DT0A
DFGin None 3 23.1% 8B99A
None None 1 7.7% 5OBRA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_HUMAN 3AMAA P17612 2 351 351.0 SKE:60351 Type1 Active DFGin 5.0968 14.0258 BLAminus -113.5, 162.11 72.12, 95.43 -101.12, 20.61 280.01, 66.12 -51.23, -34.47 in-in in 9.396 Saltbr-in 2.7343 HRD-in -88.12, -51.56 68.22, 12.75 in-in-in SNCiii in-in ActLoopNT-in 2.9104 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.04, 164.64 APE9-dihe-na 124.94, -160.1 APE8-dihe-in -123.9, 133.09 APE8-rot-in 298.24 APE67-dihe-in -57.85, -22.29 -46.67, -50.91 APE12-dist-in 8.1018 APE11-dist-in 11.5706 APE10-dist-in 5.9018 APE9-dist-in 3.5818 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.75 0.198 0.223 A 351.0 345.0 0 25 25 0 [[44, 298]] 1.0 3ama AGC_PRKACA_HUMAN AGC 7.9e-93 316.4 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK AURKA AURKA_HUMAN 5DPVA O14965 127 389 403.0 5DN:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2227 16.2094 ABAminus -110.93, -43.26 -110.84, 101.02 -87.51, 23.53 278.79, 82.59 -59.61, -51.22 out-in out 10.5383 Saltbr-in 3.388 HRD-in -62.88, -51.13 56.61, 19.56 in-in-out SNCiio in-out ActLoopNT-in 3.1231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 144.36 APE9-dihe-na -94.43, -124.73 APE8-dihe-in -73.05, 138.31 APE8-rot-in 266.66 APE67-dihe-in -36.64, -38.36 -81.1, -11.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.4807 APE9-dist-out 10.3541 T287A None None XRAY 2.285 0.225 0.28 A 273.0 257.0 6 26 20 6 [[133, 383]] 1.0 5dpv CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR6A O14965 127 390 403.0 5E1:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2554 16.2435 ABAminus -109.16, -45.28 -112.39, 100.25 -88.77, 25.04 278.19, 83.44 -61.53, -50.53 out-in out 10.5931 Saltbr-in 3.4325 HRD-in -66.11, -48.32 65.82, 8.05 in-in-out SNCiio in-out ActLoopNT-in 2.9691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 145.11 APE9-dihe-na -94.91, -119.28 APE8-dihe-in -76.91, 137.76 APE8-rot-in 267.0 APE67-dihe-in -38.0, -37.59 -81.57, -10.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3936 APE9-dist-out 10.6234 T287A None None XRAY 2.534 0.221 0.278 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr6 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT0A O14965 127 390 403.0 SKE:401 Type1 Inactive DFGin 6.5507 16.3624 ABAminus -112.57, -43.63 -110.17, 94.56 -84.52, 17.21 279.45, 83.16 -58.42, -46.55 in-in in 9.1873 Saltbr-in 2.524 HRD-in -64.82, -50.09 61.67, 8.23 in-in-out SNCiio in-out ActLoopNT-in 3.1265 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.94 APE9-dihe-na -97.93, -126.07 APE8-dihe-in -73.71, 138.78 APE8-rot-in 266.46 APE67-dihe-in -37.39, -37.4 -82.91, -12.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0428 APE9-dist-out 10.5837 None None None XRAY 2.15 0.211 0.225 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt0 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR9A O14965 127 390 403.0 SKE:401,5E2:402 Type1,Allosteric Inactive DFGin 6.2605 16.4955 BLAminus -123.32, -163.78 43.59, 60.53 -66.54, -12.27 260.09, 81.94 -59.8, 149.1 out-out out 10.8322 Saltbr-out 5.8361 HRD-in -75.67, -56.88 79.45, -32.13 out-out-out SNCooo out-out ActLoopNT-out 3.7494 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 153.82 APE9-dihe-na -93.74, -139.43 APE8-dihe-in -48.63, 139.94 APE8-rot-in 276.28 APE67-dihe-in -58.38, -35.92 -97.04, 14.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1214 APE9-dist-out 10.8202 T287A None None XRAY 2.47 0.227 0.262 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr9 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBRA O14965 126 390 403.0 9QT:401,SKE:402 Allosteric,Type1 Inactive None 11.9936 14.1133 None -120.85, 175.9 49.64, 111.5 91.55, -154.11 257.58, 58.97 124.57, 54.88 out-out out 11.6699 Saltbr-out 7.51 HRD-in -87.06, -37.27 63.65, 5.21 out-out-out SNCooo out-out ActLoopNT-out 5.706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.71 APE8-dihe-in -48.88, 148.85 APE8-rot-out 188.4 APE67-dihe-in -53.11, -27.71 -92.05, -5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6313 None None None XRAY 2.62 0.226 0.292 A 272.0 255.0 10 26 16 10 [[133, 383]] 1.0 5obr CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
STE STK24 STK24_HUMAN 4QMUA Q9Y6E0 24 310 443.0 SKE:60401 Type1 Active DFGin 6.6565 14.7742 BLAminus -136.02, 168.26 67.37, 81.34 -100.18, 19.9 289.77, 83.64 -62.59, -26.53 in-in in 8.534 Saltbr-in 2.6331 HRD-in -70.37, -50.19 74.36, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.38, 160.82 APE9-dihe-na 125.22, -165.74 APE8-dihe-in -117.97, 121.67 APE8-rot-in 305.07 APE67-dihe-in -60.15, -25.07 -46.17, -45.99 APE12-dist-in 8.1374 APE11-dist-in 10.9472 APE10-dist-in 5.1903 APE9-dist-in 3.3227 None TPO190 TPO190 XRAY 1.546 0.178 0.206 A 310.0 287.0 0 28 28 0 [[36, 286]] 1.0 4qmu STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR JAK2-2 JAK2_HUMAN 5USYA O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.2984 14.1875 BLAminus -130.23, -164.34 47.33, 79.32 -93.1, 20.71 291.84, 98.58 -62.97, -21.55 in-in in 8.6125 Saltbr-in 2.8032 HRD-in -71.47, -46.11 68.35, -0.6 in-in-none SNCiin in-none ActLoopNT-in 2.7348 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.57 APE8-dihe-in -78.81, 76.11 APE8-rot-na 30.98 APE67-dihe-in -83.0, 0.49 -61.55, -24.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2651 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 A 316.0 288.0 3 31 28 3 [[545, 807], [849, 1125]] 2.0 5usy TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5USYB O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.3085 14.2534 BLAminus -121.96, -156.65 31.13, 87.35 -93.3, 22.45 292.93, 84.2 -66.48, -18.97 in-in in 8.4429 Saltbr-in 2.9734 HRD-in -70.92, -45.61 67.52, 2.98 in-in-none SNCiin in-none ActLoopNT-in 2.7252 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.82 APE8-dihe-in -82.14, 78.44 APE8-rot-na 33.08 APE67-dihe-in -81.92, -0.91 -60.29, -26.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4059 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 B 316.0 288.0 3 31 28 3 [[545, 807], [849, 1125]] 2.0 5usy TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6DRWA O60674 840 1131 1132.0 SKE:61201 Type1 Inactive DFGin 6.2723 14.0038 BLAminus -135.62, -164.15 53.36, 70.98 -94.26, 33.85 297.13, 87.99 -70.79, -31.52 in-out in 8.2727 Saltbr-out 3.7446 HRD-in -68.89, -41.09 70.39, -6.99 out-in-none SNCoin in-none ActLoopNT-in 2.7289 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.68 APE8-dihe-in -73.32, 76.55 APE8-rot-na 28.19 APE67-dihe-in -76.44, -0.11 -65.53, -30.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4855 None PTR1007 PTR1007 XRAY 2.303 0.216 0.255 A 316.0 287.0 5 31 28 3 [[545, 807], [849, 1125]] 2.0 6drw TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.8292 13.1897 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.6139 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.8443 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.7642 APE11-dist-na 11.3667 APE10-dist-na 15.959 APE9-dist-out 12.1602 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b99 TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.2805 13.7901 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.8153 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.5544 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.5649 APE11-dist-na 11.6365 APE10-dist-na 16.0252 APE9-dist-out 12.3691 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5win TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.1469 13.1661 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.3491 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.8029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.1185 APE11-dist-na 11.6069 APE10-dist-na 16.2335 APE9-dist-out 12.8894 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5usz TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

Ligand: SKE

Total number of chains: 13
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 46.2% 4QMUA
DFGin ABAminus 3 23.1% 5DT0A
DFGin None 3 23.1% 8B99A
None None 1 7.7% 5OBRA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_HUMAN 3AMAA P17612 2 351 351.0 SKE:60351 Type1 Active DFGin 5.0968 14.0258 BLAminus -113.5, 162.11 72.12, 95.43 -101.12, 20.61 280.01, 66.12 -51.23, -34.47 in-in in 9.396 Saltbr-in 2.7343 HRD-in -88.12, -51.56 68.22, 12.75 in-in-in SNCiii in-in ActLoopNT-in 2.9104 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.04, 164.64 APE9-dihe-na 124.94, -160.1 APE8-dihe-in -123.9, 133.09 APE8-rot-in 298.24 APE67-dihe-in -57.85, -22.29 -46.67, -50.91 APE12-dist-in 8.1018 APE11-dist-in 11.5706 APE10-dist-in 5.9018 APE9-dist-in 3.5818 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.75 0.198 0.223 A 351.0 345.0 0 25 25 0 [[44, 298]] 1.0 3ama Homo sapiens AGC_PRKACA_HUMAN AGC 7.9e-93 316.4 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK AURKA AURKA_HUMAN 5DPVA O14965 127 389 403.0 5DN:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2227 16.2094 ABAminus -110.93, -43.26 -110.84, 101.02 -87.51, 23.53 278.79, 82.59 -59.61, -51.22 out-in out 10.5383 Saltbr-in 3.388 HRD-in -62.88, -51.13 56.61, 19.56 in-in-out SNCiio in-out ActLoopNT-in 3.1231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 144.36 APE9-dihe-na -94.43, -124.73 APE8-dihe-in -73.05, 138.31 APE8-rot-in 266.66 APE67-dihe-in -36.64, -38.36 -81.1, -11.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.4807 APE9-dist-out 10.3541 T287A None None XRAY 2.285 0.225 0.28 A 273.0 257.0 6 26 20 6 [[133, 383]] 1.0 5dpv Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR6A O14965 127 390 403.0 5E1:401,SKE:402 Allosteric,Type1 Inactive DFGin 6.2554 16.2435 ABAminus -109.16, -45.28 -112.39, 100.25 -88.77, 25.04 278.19, 83.44 -61.53, -50.53 out-in out 10.5931 Saltbr-in 3.4325 HRD-in -66.11, -48.32 65.82, 8.05 in-in-out SNCiio in-out ActLoopNT-in 2.9691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 145.11 APE9-dihe-na -94.91, -119.28 APE8-dihe-in -76.91, 137.76 APE8-rot-in 267.0 APE67-dihe-in -38.0, -37.59 -81.57, -10.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3936 APE9-dist-out 10.6234 T287A None None XRAY 2.534 0.221 0.278 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr6 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT0A O14965 127 390 403.0 SKE:401 Type1 Inactive DFGin 6.5507 16.3624 ABAminus -112.57, -43.63 -110.17, 94.56 -84.52, 17.21 279.45, 83.16 -58.42, -46.55 in-in in 9.1873 Saltbr-in 2.524 HRD-in -64.82, -50.09 61.67, 8.23 in-in-out SNCiio in-out ActLoopNT-in 3.1265 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.94 APE9-dihe-na -97.93, -126.07 APE8-dihe-in -73.71, 138.78 APE8-rot-in 266.46 APE67-dihe-in -37.39, -37.4 -82.91, -12.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0428 APE9-dist-out 10.5837 None None None XRAY 2.15 0.211 0.225 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt0 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR9A O14965 127 390 403.0 SKE:401,5E2:402 Type1,Allosteric Inactive DFGin 6.2605 16.4955 BLAminus -123.32, -163.78 43.59, 60.53 -66.54, -12.27 260.09, 81.94 -59.8, 149.1 out-out out 10.8322 Saltbr-out 5.8361 HRD-in -75.67, -56.88 79.45, -32.13 out-out-out SNCooo out-out ActLoopNT-out 3.7494 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 153.82 APE9-dihe-na -93.74, -139.43 APE8-dihe-in -48.63, 139.94 APE8-rot-in 276.28 APE67-dihe-in -58.38, -35.92 -97.04, 14.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1214 APE9-dist-out 10.8202 T287A None None XRAY 2.47 0.227 0.262 A 273.0 257.0 7 26 19 7 [[133, 383]] 1.0 5dr9 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBRA O14965 126 390 403.0 9QT:401,SKE:402 Allosteric,Type1 Inactive None 11.9936 14.1133 None -120.85, 175.9 49.64, 111.5 91.55, -154.11 257.58, 58.97 124.57, 54.88 out-out out 11.6699 Saltbr-out 7.51 HRD-in -87.06, -37.27 63.65, 5.21 out-out-out SNCooo out-out ActLoopNT-out 5.706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.71 APE8-dihe-in -48.88, 148.85 APE8-rot-out 188.4 APE67-dihe-in -53.11, -27.71 -92.05, -5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6313 None None None XRAY 2.62 0.226 0.292 A 272.0 255.0 10 26 16 10 [[133, 383]] 1.0 5obr Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
STE STK24 STK24_HUMAN 4QMUA Q9Y6E0 24 310 443.0 SKE:60401 Type1 Active DFGin 6.6565 14.7742 BLAminus -136.02, 168.26 67.37, 81.34 -100.18, 19.9 289.77, 83.64 -62.59, -26.53 in-in in 8.534 Saltbr-in 2.6331 HRD-in -70.37, -50.19 74.36, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.38, 160.82 APE9-dihe-na 125.22, -165.74 APE8-dihe-in -117.97, 121.67 APE8-rot-in 305.07 APE67-dihe-in -60.15, -25.07 -46.17, -45.99 APE12-dist-in 8.1374 APE11-dist-in 10.9472 APE10-dist-in 5.1903 APE9-dist-in 3.3227 None TPO190 TPO190 XRAY 1.546 0.178 0.206 A 310.0 287.0 0 28 28 0 [[36, 286]] 1.0 4qmu Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR JAK2-2 JAK2_HUMAN 5USYA O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.2984 14.1875 BLAminus -130.23, -164.34 47.33, 79.32 -93.1, 20.71 291.84, 98.58 -62.97, -21.55 in-in in 8.6125 Saltbr-in 2.8032 HRD-in -71.47, -46.11 68.35, -0.6 in-in-none SNCiin in-none ActLoopNT-in 2.7348 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.57 APE8-dihe-in -78.81, 76.11 APE8-rot-na 30.98 APE67-dihe-in -83.0, 0.49 -61.55, -24.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2651 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 A 316.0 288.0 3 31 28 3 [[545, 807], [849, 1125]] 2.0 5usy Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5USYB O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.3085 14.2534 BLAminus -121.96, -156.65 31.13, 87.35 -93.3, 22.45 292.93, 84.2 -66.48, -18.97 in-in in 8.4429 Saltbr-in 2.9734 HRD-in -70.92, -45.61 67.52, 2.98 in-in-none SNCiin in-none ActLoopNT-in 2.7252 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.82 APE8-dihe-in -82.14, 78.44 APE8-rot-na 33.08 APE67-dihe-in -81.92, -0.91 -60.29, -26.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4059 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 B 316.0 288.0 3 31 28 3 [[545, 807], [849, 1125]] 2.0 5usy Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6DRWA O60674 840 1131 1132.0 SKE:61201 Type1 Inactive DFGin 6.2723 14.0038 BLAminus -135.62, -164.15 53.36, 70.98 -94.26, 33.85 297.13, 87.99 -70.79, -31.52 in-out in 8.2727 Saltbr-out 3.7446 HRD-in -68.89, -41.09 70.39, -6.99 out-in-none SNCoin in-none ActLoopNT-in 2.7289 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.68 APE8-dihe-in -73.32, 76.55 APE8-rot-na 28.19 APE67-dihe-in -76.44, -0.11 -65.53, -30.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4855 None PTR1007 PTR1007 XRAY 2.303 0.216 0.255 A 316.0 287.0 5 31 28 3 [[545, 807], [849, 1125]] 2.0 6drw Homo sapiens TYR_JAK2-2_HUMAN TYR 3.2e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.8292 13.1897 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.6139 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.8443 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.7642 APE11-dist-na 11.3667 APE10-dist-na 15.959 APE9-dist-out 12.1602 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b99 Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.2805 13.7901 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.8153 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.5544 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.5649 APE11-dist-na 11.6365 APE10-dist-na 16.0252 APE9-dist-out 12.3691 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5win Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.1469 13.1661 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.3491 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.8029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.1185 APE11-dist-na 11.6069 APE10-dist-na 16.2335 APE9-dist-out 12.8894 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5usz Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

Ligand: SKE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name