Protein kinases in complex with BWC (Toceranib)

Total number of genes: 1
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGout BBAminus 1 9N7RB
DFGout None 1 9N7RA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 9N7RB 2.13 Inactive DFGout BBAminus out-out out-out A1BWC Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 9N7RA 2.13 Inactive DFGout None out-out out-out A1BWC A1BWC A1BWC A1BWC Allosteric Allosteric Type1 Type3

Protein kinases in complex with BWC

Total number of genes: 2
Total number of chains: 4
Spatial Dihedral Chains Representative
DFGin BLAminus 2 6M13a
DFGout BBAminus 1 9N7RB
DFGout None 1 9N7RA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 9N7RB 2.13 Inactive DFGout BBAminus out-out out-out A1BWC Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 9N7RA 2.13 Inactive DFGout None out-out out-out A1BWC A1BWC A1BWC A1BWC Allosteric Allosteric Type1 Type3
Sus scrofa OTHER RNASEL A5H025_PIG Ribonuclease L 6M13a 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric
Sus scrofa OTHER RNASEL A5H025_PIG Ribonuclease L 6M13b 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric

Protein kinases in complex with BWC

Total number of genes: 1
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGin BLAminus 2 6M13a
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Sus scrofa OTHER RNASEL A5H025_PIG Ribonuclease L 6M13a 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric
Sus scrofa OTHER RNASEL A5H025_PIG Ribonuclease L 6M13b 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric