Ligand: BWC (Toceranib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 1 50.0% 9N7RB
DFGout None 1 50.0% 9N7RA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP4K1 M4K1_HUMAN 9N7RB 2.13 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWC Type1 8 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1

Ligand: BWC (Toceranib)

Total number of chains: 4
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% 6M13a
DFGout BBAminus 1 25.0% 9N7RB
DFGout None 1 25.0% 9N7RA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP4K1 M4K1_HUMAN 9N7RB 2.13 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWC Type1 8 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
OTHER RNASEL A5H025_PIG 6M13A 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 22 - 727 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 6M13B 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 23 - 729 0 None None Ribonuclease L Sus scrofa

Ligand: BWC (Toceranib)

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 6M13a
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER RNASEL A5H025_PIG 6M13A 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 22 - 727 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 6M13B 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 23 - 729 0 None None Ribonuclease L Sus scrofa