Ligand: AMP

Total number of chains: 28
Active chains: 14
Total number of genes: 11
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 78.6% 7P7GA
DFGin BLBplus 3 10.7% 6P8QC
DFGin ABAminus 2 7.1% 7N8TA
DFGin None 1 3.6% 9GUCA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK6 GRK6_HUMAN 3NYOA P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.423 12.986 BLAminus -150.32, 176.66 46.57, 93.99 -112.64, 27.92 269.12, 56.38 -53.19, -36.92 in-in in 8.492 Saltbr-in 3.133 HRD-in -67.42, -53.58 67.41, 17.23 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.58, 145.08 APE9-dihe-na 153.72, -154.4 APE8-dihe-in -119.63, 125.01 APE8-rot-in 309.24 APE67-dihe-inflip 99.19, -30.43 -48.0, 129.76 APE12-dist-in 10.102 APE11-dist-in 11.881 APE10-dist-in 6.152 APE9-dist-in 3.985 None None None XRAY 2.92 0.222 0.253 A 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOB P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.469 12.921 BLAminus -147.57, -176.88 49.48, 66.09 -89.42, 43.68 283.74, 78.16 -61.9, -48.01 in-in in 8.429 Saltbr-in 2.859 HRD-in -67.89, -44.49 63.77, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 138.67 APE9-dihe-na 143.94, 179.93 APE8-dihe-in -100.37, 135.53 APE8-rot-in 311.67 APE67-dihe-inflip 96.9, -39.59 -38.27, 126.0 APE12-dist-in 10.148 APE11-dist-in 11.731 APE10-dist-in 5.96 APE9-dist-in 3.734 None None None XRAY 2.92 0.222 0.253 B 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
CAMK AURKA AURKA_HUMAN 6VPMA O14965 7 389 403.0 AMP:60602,R74:60603 ATPlike,Allosteric Inactive DFGin 5.511 15.785 BLAminus -126.3, 179.56 64.46, 79.19 -94.31, 22.45 283.25, 78.95 -62.44, -22.15 out-out out 10.465 Saltbr-out 4.632 HRD-in -82.12, -50.43 74.02, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -94.21, -5.66 APE9-dihe-na -50.93, -40.67 APE8-dihe-in -122.63, 120.42 APE8-rot-out 167.52 APE67-dihe-in -61.47, -28.56 -78.55, -11.77 APE12-dist-out 25.847 APE11-dist-out 21.306 APE10-dist-out 23.19 APE9-dist-out 28.096 None TPO288 TPO288 XRAY 1.58 0.17 0.203 A 292 262 4 0 0 4 [[133, 383]] 1.0 6vpm CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPMB O14965 7 389 403.0 AMP:60601,R74:60602 ATPlike,Allosteric Inactive DFGin 5.618 16.171 BLAminus -126.47, 179.26 64.24, 79.8 -93.68, 23.42 285.18, 79.92 -68.14, -17.47 out-out out 10.727 Saltbr-out 4.785 HRD-in -77.29, -52.49 74.53, -0.08 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.93, -6.99 APE9-dihe-na -61.27, -34.46 APE8-dihe-in -116.01, 94.69 APE8-rot-in 318.22 APE67-dihe-in -54.76, -31.62 -74.36, -14.23 APE12-dist-out 26.016 APE11-dist-out 21.519 APE10-dist-out 23.63 APE9-dist-out 28.431 None TPO288 TPO288 XRAY 1.58 0.17 0.203 B 292 262 4 0 0 4 [[133, 383]] 1.0 6vpm CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.177 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.881 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.708 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285 256 12 0 0 12 [[133, 383]] 1.0 9guc CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CASK CSKP_HUMAN 3C0HA O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.602 15.272 BLAminus -127.83, -151.84 62.45, 48.02 -88.8, 12.97 279.71, 88.33 -53.45, -27.37 in-in in 9.984 Saltbr-in 3.32 HRD-in -71.81, -47.22 72.01, -10.53 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 145.94 APE9-dihe-na 100.98, -162.69 APE8-dihe-in -107.97, 118.32 APE8-rot-in 308.41 APE67-dihe-in -60.72, -23.96 -42.45, -43.89 APE12-dist-in 13.036 APE11-dist-in 12.314 APE10-dist-in 6.82 APE9-dist-in 3.701 None None None XRAY 2.3 0.191 0.239 A 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HB O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.6 15.203 BLAminus -120.68, -148.62 53.86, 55.42 -94.09, 23.7 283.84, 83.03 -57.86, -26.99 in-in in 9.535 Saltbr-in 3.011 HRD-in -71.85, -49.31 73.45, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.66, 151.11 APE9-dihe-na 98.76, -158.5 APE8-dihe-in -113.67, 120.11 APE8-rot-in 310.97 APE67-dihe-in -61.76, -24.04 -43.49, -43.68 APE12-dist-in 12.992 APE11-dist-in 12.203 APE10-dist-in 6.64 APE9-dist-in 3.716 None None None XRAY 2.3 0.191 0.239 B 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK PIM1 PIM1_HUMAN 1YXUA P11309 33 305 313.0 AMP:550 ATPlike Active DFGin 6.045 14.58 BLAminus -128.48, 170.01 62.85, 77.77 -90.35, 20.24 287.6, 77.99 -74.7, 1.63 in-in in 8.513 Saltbr-in 2.486 HRD-na-A -60.24, -50.74 67.33, 4.52 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.18, 25.46 APE9-dihe-na -90.91, -158.18 APE8-dihe-in -86.5, 120.86 APE8-rot-in 310.09 APE67-dihe-in -63.06, -9.2 -60.21, -45.83 APE12-dist-in 9.959 APE11-dist-in 8.835 APE10-dist-in 5.689 APE9-dist-in 3.869 None None None XRAY 2.24 0.231 0.276 A 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUB P11309 33 305 313.0 AMP:650 ATPlike Active DFGin 6.12 14.673 BLAminus -120.37, 167.93 65.74, 85.44 -95.36, 14.03 285.37, 78.45 -64.71, -9.22 in-in in 8.6 Saltbr-in 2.814 HRD-na-A -59.51, -51.25 68.06, 6.92 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.12, 36.18 APE9-dihe-na -84.74, -152.35 APE8-dihe-in -93.27, 122.65 APE8-rot-in 302.12 APE67-dihe-in -68.21, -7.03 -55.31, -45.11 APE12-dist-in 9.8 APE11-dist-in 8.534 APE10-dist-in 5.457 APE9-dist-in 3.841 None None None XRAY 2.24 0.231 0.276 B 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUC P11309 34 305 313.0 AMP:750 ATPlike Active DFGin 6.11 14.741 BLAminus -134.94, 167.86 62.59, 83.1 -95.62, 21.45 280.06, 80.63 -81.83, 7.92 in-in in 8.716 Saltbr-in 2.612 HRD-na-A -67.31, -48.53 67.93, 5.85 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.01, 44.98 APE9-dihe-na -103.92, -155.25 APE8-dihe-in -86.11, 117.99 APE8-rot-in 310.09 APE67-dihe-in -68.22, -9.23 -52.45, -45.39 APE12-dist-in 9.697 APE11-dist-in 8.654 APE10-dist-in 5.604 APE9-dist-in 3.847 None None None XRAY 2.24 0.231 0.276 C 293 272 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUD P11309 33 305 313.0 AMP:850 ATPlike Active DFGin 6.236 14.556 BLAminus -126.04, 169.08 67.7, 73.28 -88.52, 13.94 289.01, 78.99 -70.28, -2.85 in-in in 8.789 Saltbr-in 2.466 HRD-na-A -64.06, -51.29 66.47, 10.4 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.8, 31.82 APE9-dihe-na -93.66, -159.09 APE8-dihe-in -85.99, 118.35 APE8-rot-in 303.12 APE67-dihe-in -71.66, -13.36 -52.91, -39.75 APE12-dist-in 9.896 APE11-dist-in 8.645 APE10-dist-in 5.457 APE9-dist-in 3.827 None None None XRAY 2.24 0.231 0.276 D 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CK1 CSNK1D KC1D_HUMAN 7P7FA P48730 3 294 415.0 AMP:305 ATPlike Active DFGin 6.386 14.989 BLAminus -135.41, 179.24 65.29, 82.6 -99.51, 20.86 287.48, 77.77 -56.63, -36.85 in-in in 8.099 Saltbr-in 2.591 HRD-in -82.17, -51.93 74.76, 11.47 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.01, 118.96 APE9-dihe-na 109.81, -163.5 APE8-dihe-in -91.97, 119.49 APE8-rot-in 320.94 APE67-dihe-in -55.9, -38.32 -51.55, -37.41 APE12-dist-in 13.114 APE11-dist-in 12.585 APE10-dist-in 6.845 APE9-dist-in 3.948 None TPO220 TPO220 XRAY 1.96 0.19 0.221 A 296 292 0 0 0 0 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FB P48730 3 294 415.0 AMP:310 ATPlike Active DFGin 6.389 15.041 BLAminus -134.9, -178.65 62.6, 84.78 -99.93, 21.19 288.23, 78.97 -57.89, -34.16 in-in in 8.117 Saltbr-in 2.593 HRD-in -86.23, -54.05 76.65, 11.34 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.84, 118.88 APE9-dihe-na 108.83, -162.51 APE8-dihe-in -93.95, 118.29 APE8-rot-in 320.41 APE67-dihe-in -55.93, -38.53 -50.49, -37.42 APE12-dist-in 13.14 APE11-dist-in 12.546 APE10-dist-in 6.804 APE9-dist-in 4.014 None TPO220 TPO220 XRAY 1.96 0.19 0.221 B 296 292 0 0 0 0 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7GA P48730 8 294 415.0 AMP:303 ATPlike Inactive DFGin 6.503 15.21 BLAminus -125.58, -175.5 62.42, 84.62 -97.89, 21.28 284.93, 73.84 -62.65, -25.46 in-in in 8.252 Saltbr-in 3.016 HRD-in -80.32, -51.03 68.77, 15.13 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -121.17, 158.18 APE9-dihe-na 70.26, -143.4 APE8-dihe-in -92.54, 123.25 APE8-rot-out 48.69 APE67-dihe-in -52.86, -40.08 -97.14, -14.35 APE12-dist-out 14.057 APE11-dist-in 12.931 APE10-dist-out 9.429 APE9-dist-out 8.015 None TPO220 TPO220 XRAY 1.7 0.173 0.208 A 296 287 0 0 0 0 [[9, 275]] 1.0 7p7g CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7GB P48730 7 293 415.0 AMP:307 ATPlike Inactive DFGin 6.484 14.825 BLAminus -126.09, 178.73 70.29, 86.32 -102.39, 14.25 288.72, 93.03 -61.48, -28.95 in-in in 8.084 Saltbr-in 3.028 HRD-in -71.5, -47.28 67.0, 16.77 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -110.74, 162.01 APE9-dihe-na -98.48, -144.78 APE8-dihe-in -45.03, 124.48 APE8-rot-out 164.69 APE67-dihe-in -57.08, -42.44 -74.38, -40.7 APE12-dist-in 7.209 APE11-dist-out 6.613 APE10-dist-out 8.393 APE9-dist-in 3.884 None TPO220 TPO220 XRAY 1.7 0.173 0.208 B 296 283 2 0 0 0 [[9, 275]] 1.0 7p7g CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HA P48730 3 294 415.0 AMP:301 ATPlike Active DFGin 5.85 14.904 BLAminus -131.69, 175.32 69.71, 86.46 -98.17, 29.2 291.07, 84.43 -61.3, -36.51 in-in in 8.328 Saltbr-in 2.869 HRD-in -85.02, -56.99 74.97, 14.35 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.26, -19.24 APE9-dihe-na -88.34, -159.24 APE8-dihe-in -92.63, 127.36 APE8-rot-in 313.8 APE67-dihe-in -57.88, -32.21 -74.29, -29.96 APE12-dist-in 10.816 APE11-dist-in 12.399 APE10-dist-in 6.988 APE9-dist-in 4.101 None None None XRAY 2.4 0.225 0.268 A 296 292 0 0 0 0 [[9, 275]] 1.0 7p7h CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HB P48730 3 294 415.0 AMP:301 ATPlike Active DFGin 5.843 14.916 BLAminus -130.5, 174.9 69.57, 86.72 -100.58, 28.91 292.34, 82.14 -57.01, -35.01 in-in in 8.325 Saltbr-in 2.918 HRD-in -84.55, -57.9 81.6, 9.08 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.93, 49.41 APE9-dihe-na 140.08, -131.01 APE8-dihe-in -99.84, 119.2 APE8-rot-in 321.52 APE67-dihe-in -56.55, -33.9 -75.78, -27.7 APE12-dist-in 12.421 APE11-dist-in 12.165 APE10-dist-in 7.215 APE9-dist-in 4.736 None None None XRAY 2.4 0.225 0.268 B 296 292 0 0 0 0 [[9, 275]] 1.0 7p7h CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 4IMYC P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.789 15.123 BLAminus -140.61, 175.84 60.41, 77.79 -97.02, 19.01 284.69, 80.72 -68.98, -8.54 in-in in 9.232 Saltbr-in 2.833 HRD-in -67.68, -50.97 65.16, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.81, 161.81 APE9-dihe-na 73.71, 135.92 APE8-dihe-in -53.34, 141.57 APE8-rot-in 294.85 APE67-dihe-in -61.16, -25.06 -47.9, -50.46 APE12-dist-in 13.386 APE11-dist-in 11.431 APE10-dist-in 7.006 APE9-dist-in 3.279 None TPO186 TPO186 XRAY 2.94 0.209 0.245 C 332 311 12 0 0 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4IMYE P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.794 15.112 BLAminus -141.41, 175.75 59.75, 77.9 -96.66, 19.65 284.44, 80.03 -69.65, -8.18 in-in in 9.197 Saltbr-in 2.816 HRD-in -68.02, -51.11 68.06, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.97, 161.65 APE9-dihe-na 74.14, 135.63 APE8-dihe-in -53.23, 140.74 APE8-rot-in 294.81 APE67-dihe-in -59.86, -25.62 -47.7, -50.88 APE12-dist-in 13.405 APE11-dist-in 11.437 APE10-dist-in 7.01 APE9-dist-in 3.278 None TPO186 TPO186 XRAY 2.94 0.209 0.245 E 332 314 9 0 0 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4IMYA P50750 8 330 372.0 AMP:401 Type1.5_Back Active DFGin 6.761 15.126 BLAminus -140.16, 177.94 57.41, 78.2 -96.63, 19.81 285.27, 81.22 -68.88, -9.41 in-in in 9.227 Saltbr-in 2.849 HRD-in -67.2, -51.3 65.19, 13.63 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 161.25 APE9-dihe-na 74.17, 135.57 APE8-dihe-in -52.35, 140.79 APE8-rot-in 295.69 APE67-dihe-in -60.8, -24.95 -48.08, -50.31 APE12-dist-in 13.39 APE11-dist-in 11.433 APE10-dist-in 7.009 APE9-dist-in 3.27 None TPO186 TPO186 XRAY 2.94 0.209 0.245 A 332 315 8 0 0 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC MAPK10 MK10_HUMAN 4KKEA P53779 45 400 464.0 AMP:501 ATPlike Inactive DFGin 3.889 14.134 ABAminus -83.98, -33.4 -131.72, 175.68 -114.08, 11.08 302.89, 82.85 75.62, -152.87 in-out in 9.705 Saltbr-out 5.629 HRD-in -71.56, -61.65 73.66, -1.84 out-out-out SNCooo out-out ActLoopNT-out 5.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -98.43, 129.33 APE9-dihe-na -82.63, 139.65 APE8-dihe-in -89.17, 118.02 APE8-rot-in 308.05 APE67-dihe-in -54.19, -24.02 -104.28, -7.92 APE12-dist-out 21.356 APE11-dist-out 16.314 APE10-dist-out 17.192 APE9-dist-out 11.507 None None None XRAY 2.2 0.233 0.291 A 365 354 2 0 0 2 [[64, 359]] 1.0 4kke CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK9 MK09_HUMAN 7N8TA P45984 10 364 424.0 AMP:401 ATPlike Inactive DFGin 4.063 14.828 ABAminus -84.92, -27.07 -147.51, 174.64 -99.27, 14.32 294.67, 92.77 76.31, -156.58 in-out in 9.829 Saltbr-out 6.299 HRD-in -68.91, -54.33 71.52, -2.96 out-out-out SNCooo out-out ActLoopNT-out 6.256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -98.36, 119.43 APE9-dihe-na -82.83, -52.5 APE8-dihe-in -95.69, 109.67 APE8-rot-in 308.73 APE67-dihe-in -71.55, -16.34 -115.42, 5.92 APE12-dist-in 9.622 APE11-dist-in 13.952 APE10-dist-out 10.595 APE9-dist-out 11.989 None None None XRAY 1.69 0.192 0.22 A 355 355 0 0 0 0 [[26, 321]] 1.0 7n8t CMGC_MAPK9_HUMAN CMGC 7.5e-84 287.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
OTHER HASPIN HASP_HUMAN 3DLZA Q8TF76 470 798 798.0 AMP:902 ATPlike Active DFGin 5.254 12.469 BLAminus -120.14, 174.05 73.32, 91.07 -105.92, 29.14 315.79, 130.04 -57.27, -36.15 in-in in 9.264 Saltbr-in 2.695 HRD-na-N -71.0, -49.07 68.99, 3.03 in-in-na SNCiia in-na ActLoopNT-in 2.821 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -122.28, 17.39 APE9-dihe-na -67.57, 157.85 APE8-dihe-na -149.51, 177.99 APE8-rot-na 58.52 APE67-dihe-na -159.03, 144.74 95.06, -6.22 APE12-dist-na 9.493 APE11-dist-na 13.466 APE10-dist-na 17.05 APE9-dist-na 12.819 None None None XRAY 1.85 0.167 0.216 A 357 329 0 0 0 0 [[484, 797]] 1.0 3dlz OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
TYR EGFR EGFR_HUMAN 6P8QB P00533 698 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.276 14.467 BLBplus -135.86, 166.31 67.07, 15.83 -64.3, 136.34 50.27, 96.09 85.52, -9.82 out-out out 13.54 Saltbr-out 13.7 HRD-in -74.24, -59.24 89.14, -20.92 out-out-none SNCoon out-none ActLoopNT-out 6.974 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.09 APE9-dihe-in -104.23, 113.6 APE8-dihe-in -82.27, 71.52 APE8-rot-na 22.76 APE67-dihe-in -69.35, -13.24 -58.74, -40.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.877 APE9-dist-in 7.993 T790M,V948R None None XRAY 1.9 0.169 0.195 B 327 300 10 0 0 10 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QC P00533 699 1014 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.309 14.59 BLBplus -130.27, 166.7 65.36, 18.32 -66.06, 140.33 49.17, 97.15 81.91, -12.21 out-out out 13.83 Saltbr-out 13.591 HRD-in -81.24, -59.54 87.32, -15.78 out-out-in SNCooi out-in ActLoopNT-out 6.911 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.57, 147.96 APE9-dihe-in -130.06, 156.46 APE8-dihe-in -83.94, 74.96 APE8-rot-na 27.22 APE67-dihe-in -70.93, -14.87 -56.96, -36.77 APE12-dist-na 16.927 APE11-dist-na 13.676 APE10-dist-na 14.094 APE9-dist-in 7.721 T790M,V948R None None XRAY 1.9 0.169 0.195 C 327 316 0 0 0 0 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QD P00533 700 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.367 14.316 BLBplus -131.89, 166.57 70.0, 15.99 -68.19, 140.48 43.77, 99.15 83.83, -10.13 out-out out 13.426 Saltbr-out 13.149 HRD-in -73.29, -58.03 87.0, -17.51 out-out-none SNCoon out-none ActLoopNT-out 6.894 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 92.37 APE8-dihe-in -76.46, 76.63 APE8-rot-na 30.25 APE67-dihe-in -71.2, -11.99 -56.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.449 T790M,V948R None None XRAY 1.9 0.169 0.195 D 327 296 12 0 0 12 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR RET RET_HUMAN 2IVTA P07949 703 1012 1114.0 AMP:63015 ATPlike Inactive DFGin 6.582 14.046 BLAminus -135.2, 176.38 61.74, 80.34 -103.81, 14.47 281.76, 90.09 -59.35, -34.21 in-in in 7.234 Saltbr-in 2.737 HRD-in -77.56, -43.39 78.85, -29.33 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.53, 33.76 APE9-dihe-in -110.13, 138.63 APE8-dihe-in -57.62, 135.06 APE8-rot-na 332.88 APE67-dihe-in -80.74, -4.59 -59.92, -27.73 APE12-dist-na 13.764 APE11-dist-na 9.424 APE10-dist-na 8.046 APE9-dist-in 5.596 None PTR905 PTR905 XRAY 2.6 0.187 0.249 A 314 286 21 0 0 0 [[724, 1007]] 1.0 2ivt TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 6NE7A P07949 705 1013 1114.0 AMP:61103 ATPlike Inactive DFGin 6.727 14.262 BLAminus -136.24, -174.2 57.88, 74.27 -97.52, 17.22 284.41, 79.78 -59.81, -27.59 in-in in 7.093 Saltbr-in 2.608 HRD-in -73.16, -50.61 79.87, -20.93 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.57, 19.09 APE9-dihe-in -87.06, 133.71 APE8-dihe-in -50.0, 126.08 APE8-rot-na 331.41 APE67-dihe-in -72.8, -6.12 -42.6, -44.71 APE12-dist-na 13.52 APE11-dist-na 9.107 APE10-dist-na 7.618 APE9-dist-in 5.218 G810A PTR900,PTR905 PTR900,PTR905 XRAY 1.99 0.206 0.249 A 314 290 19 0 0 0 [[724, 1007]] 1.0 6ne7 TYR_RET_HUMAN TYR 7.8e-100 339.4 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: AMP

Total number of chains: 48
Active chains: 27
Total number of genes: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 39 81.2% 6ESAA
DFGin BLBplus 5 10.4% 6P8QC
DFGin ABAminus 2 4.2% 7N8TA
DFGin BLBminus 1 2.1% 3GC0A
DFGin None 1 2.1% 9GUCA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QA A0A1D8PUA2 4 333 335.0 AMP:401 ATPlike Active DFGin 7.386 16.256 BLAminus -114.24, -174.82 59.27, 62.07 -85.23, 23.85 304.56, 80.46 -69.03, -20.65 in-in in 9.001 Saltbr-in 2.88 HRD-in -68.75, -45.06 62.13, 23.87 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.59, 173.17 APE9-dihe-na 57.84, -166.47 APE8-dihe-in -122.64, 160.2 APE8-rot-in 318.49 APE67-dihe-in -66.36, -14.81 -53.74, -47.77 APE12-dist-in 12.507 APE11-dist-in 10.219 APE10-dist-in 6.094 APE9-dist-in 3.225 None None None XRAY 2.7 0.236 0.287 A 335 326 4 0 0 0 [[43, 327]] 1.0 6o6q Candida albicans CMGC_CKA1_CANAL CMGC 1.1e-62 217.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 Casein kinase II subunit alpha
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QB A0A1D8PUA2 5 333 335.0 AMP:401 ATPlike Active DFGin 7.292 15.98 BLAminus -125.13, -179.74 57.94, 64.68 -85.91, 27.32 303.1, 76.17 -70.46, -30.29 in-in in 9.011 Saltbr-in 2.813 HRD-in -81.71, -46.62 63.63, 27.36 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.56, 167.57 APE9-dihe-na 58.76, -171.72 APE8-dihe-in -113.79, 160.74 APE8-rot-in 318.5 APE67-dihe-in -64.2, -12.3 -53.09, -54.06 APE12-dist-in 12.689 APE11-dist-in 10.132 APE10-dist-in 6.255 APE9-dist-in 3.214 None None None XRAY 2.7 0.236 0.287 B 335 325 4 0 0 0 [[43, 327]] 1.0 6o6q Candida albicans CMGC_CKA1_CANAL CMGC 1.1e-62 217.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 Casein kinase II subunit alpha
AGC PRKACA KAPCA_CRIGR 6EH2A P25321 1 351 351.0 AMP:60401 ATPlike None DFGin 6.764 14.919 BLAminus -126.18, 164.33 76.56, 92.11 -105.87, 26.81 282.23, 79.7 -66.18, -22.24 in-none in 9.226 Saltbr-none 999.0 HRD-in -87.75, -53.65 70.54, 10.24 none-in-in SNCnii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.34, 158.08 APE9-dihe-na 131.59, -168.87 APE8-dihe-in -114.41, 135.93 APE8-rot-in 298.36 APE67-dihe-in -58.8, -22.41 -48.5, -50.6 APE12-dist-in 8.204 APE11-dist-in 11.426 APE10-dist-in 5.845 APE9-dist-in 3.719 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.76 0.177 0.21 A 353 343 3 0 0 0 [[44, 298]] 1.0 6eh2 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ESAA P25321 11 351 351.0 AMP:60401 ATPlike Active DFGin 6.139 14.365 BLAminus -120.63, 169.73 70.22, 89.96 -100.72, 24.5 270.85, 56.09 -58.05, -28.66 in-in in 8.691 Saltbr-in 2.873 HRD-in -93.01, -53.86 73.79, 10.3 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.44, 160.95 APE9-dihe-na 124.73, -163.46 APE8-dihe-in -117.05, 136.25 APE8-rot-in 299.26 APE67-dihe-in -59.89, -22.61 -49.24, -49.61 APE12-dist-in 8.091 APE11-dist-in 11.499 APE10-dist-in 5.822 APE9-dist-in 3.66 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.307 0.132 0.147 A 353 341 0 0 0 0 [[44, 298]] 1.0 6esa Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK CDPK1 A3FQ16_CRYPI 4Y5QA A3FQ16 70 537 538.0 AMP:60605 ATPlike Inactive DFGin 6.637 13.313 BLBplus -122.31, 173.29 68.1, 63.18 -158.9, 162.15 65.79, 84.8 99.05, -5.3 out-out out 13.961 Saltbr-out 15.153 HRD-in -71.3, -60.7 96.16, -22.83 out-out-out SNCooo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -93.85, 128.76 APE9-dihe-na 87.94, -2.34 APE8-dihe-out -58.24, -34.23 APE8-rot-out 195.73 APE67-dihe-in -60.61, -30.52 -58.8, -23.01 APE12-dist-out 20.841 APE11-dist-out 16.757 APE10-dist-out 22.574 APE9-dist-out 12.912 None None None XRAY 2.0 0.185 0.23 A 486 445 3 0 0 3 [[76, 332]] 1.0 4y5q Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.4e-90 308.1 1 256 256 218 219 220 222 224 105 123 127 195 197 196 198 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
CAMK CDPK1 A3FQ16_CRYPI 9D8SA A3FQ16 70 532 538.0 AMP:60601 ATPlike Inactive DFGin 6.46 13.578 BLBplus -128.41, 175.33 67.41, 57.43 -151.12, 166.1 65.63, 83.45 93.31, -10.38 out-out out 14.211 Saltbr-out 11.701 HRD-in -69.48, -54.89 79.68, -12.65 out-out-out SNCooo out-out ActLoopNT-out 8.836 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -57.81, -43.02 APE9-dihe-na -64.02, -42.45 APE8-dihe-out -59.86, -31.42 APE8-rot-in 285.42 APE67-dihe-in -59.31, -25.74 -61.84, -33.7 APE12-dist-out 17.325 APE11-dist-out 17.991 APE10-dist-out 22.08 APE9-dist-out 11.468 None None None XRAY 2.12 0.21 0.243 A 492 413 3 0 0 0 [[76, 332]] 1.0 9d8s Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.5e-90 308.1 1 256 256 218 219 220 222 224 105 123 127 195 197 196 198 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
OTHER PK1 A0A097P1P8_GVCP 6VVGA A0A097P1P8 3 279 279.0 AMP:301 ATPlike Active DFGin 9.47 12.504 BLAminus -139.45, 174.39 59.11, 72.82 -82.01, 20.88 324.49, 136.4 -73.16, -16.8 na-na na 15.471 Saltbr-na 12.976 HRD-in -69.17, -49.37 73.82, 3.86 na-in-in SNCaii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.58, 157.03 APE9-dihe-na 90.57, -158.23 APE8-dihe-in -103.25, 120.97 APE8-rot-in 311.05 APE67-dihe-in -75.71, -2.76 -55.41, -39.8 APE12-dist-in 10.799 APE11-dist-in 12.039 APE10-dist-in 6.083 APE9-dist-in 4.885 None None None XRAY 2.01 0.195 0.225 A 279 267 10 0 0 0 [[17, 277]] 1.0 6vvg Cydia pomonella granulosis virus OTHER_PK1_GVCP CAMK 1.9e-45 161.2 8 256 249 159 160 161 163 165 49 62 66 138 140 139 141 195 183 178 177 176 175 174 173 172 92 PK-1
OTHER PK1 A0A097P1P8_GVCP 6VVGB A0A097P1P8 3 278 279.0 AMP:301 ATPlike Active DFGin 9.485 12.665 BLAminus -138.4, 172.21 59.64, 73.0 -83.58, 22.42 324.54, 137.78 -67.63, -19.86 na-na na 15.282 Saltbr-na 13.214 HRD-in -58.02, -51.7 78.84, -1.77 na-in-in SNCaii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.97, 161.51 APE9-dihe-na 88.81, -151.71 APE8-dihe-in -109.06, 113.8 APE8-rot-in 308.85 APE67-dihe-in -72.96, -2.91 -51.95, -43.87 APE12-dist-in 10.828 APE11-dist-in 12.169 APE10-dist-in 6.178 APE9-dist-in 4.697 None None None XRAY 2.01 0.195 0.225 B 279 264 12 0 0 0 [[17, 277]] 1.0 6vvg Cydia pomonella granulosis virus OTHER_PK1_GVCP CAMK 1.9e-45 161.2 8 256 249 159 160 161 163 165 49 62 66 138 140 139 141 195 183 178 177 176 175 174 173 172 92 PK-1
TYR SRC SRC_CHICK 3DQXA P00523 259 533 533.0 AMP:1 ATPlike Inactive DFGin 6.591 14.447 BLAminus -124.27, -171.6 57.64, 68.97 -90.49, 15.25 301.42, 90.85 -48.99, -35.86 in-out in 7.776 Saltbr-out 3.984 HRD-in -86.41, -47.88 81.53, -17.67 out-in-in SNCoii in-in ActLoopNT-in 2.914 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -145.12, 138.88 APE9-dihe-in -131.92, 130.75 APE8-dihe-in -51.07, 94.4 APE8-rot-na 337.62 APE67-dihe-in -71.42, -26.35 -38.43, -38.46 APE12-dist-na 6.86 APE11-dist-na 10.768 APE10-dist-na 12.059 APE9-dist-in 6.564 None None None XRAY 2.3 0.194 0.241 A 286 267 8 0 0 8 [[267, 518]] 1.0 3dqx Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3DQXB P00523 259 533 533.0 AMP:2 ATPlike Active DFGin 6.808 14.815 BLAminus -123.08, -167.74 51.93, 60.88 -81.23, 10.84 295.11, 95.49 -43.33, -48.19 in-in in 7.906 Saltbr-in 3.425 HRD-in -73.53, -53.77 83.73, -6.08 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.36, 128.73 APE9-dihe-in -122.57, 114.22 APE8-dihe-in -63.43, 112.38 APE8-rot-na 23.41 APE67-dihe-in -72.31, -17.76 -46.16, -42.59 APE12-dist-na 10.885 APE11-dist-na 6.755 APE10-dist-na 9.999 APE9-dist-in 5.75 None None None XRAY 2.3 0.194 0.241 B 286 268 7 0 0 7 [[267, 518]] 1.0 3dqx Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC CDK A8BZ95_GIAIC 3GC0A A8BZ95 11 308 308.0 AMP:309 ATPlike Inactive DFGin 10.734 18.123 BLBminus -99.74, 152.92 74.37, 22.26 -55.88, 137.45 246.69, 94.2 78.53, -11.24 out-none out 15.235 Saltbr-none 999.0 HRD-in -87.56, -59.97 77.29, -14.0 none-out-out SNCnoo out-out ActLoopNT-out 5.956 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nooo APE10-dihe-na -74.71, -16.76 APE9-dihe-na -60.85, -32.02 APE8-dihe-out -56.57, -42.85 APE8-rot-none 999.0 APE67-dihe-in -62.9, -23.58 -58.04, -33.64 APE12-dist-none 999.0 APE11-dist-out 17.469 APE10-dist-out 21.327 APE9-dist-out 11.763 None None None XRAY 2.0 0.199 0.265 A 329 278 20 0 0 9 [[15, 301]] 1.0 3gc0 Giardia intestinalis CMGC_CDK_GIAIC CMGC 1.5e-81 280.1 1 301 301 158 159 160 162 164 44 62 66 133 135 134 136 199 186 181 180 179 178 177 176 175 92 cyclin-dependent kinase
AGC GRK6 GRK6_HUMAN 3NYOA P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.423 12.986 BLAminus -150.32, 176.66 46.57, 93.99 -112.64, 27.92 269.12, 56.38 -53.19, -36.92 in-in in 8.492 Saltbr-in 3.133 HRD-in -67.42, -53.58 67.41, 17.23 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.58, 145.08 APE9-dihe-na 153.72, -154.4 APE8-dihe-in -119.63, 125.01 APE8-rot-in 309.24 APE67-dihe-inflip 99.19, -30.43 -48.0, 129.76 APE12-dist-in 10.102 APE11-dist-in 11.881 APE10-dist-in 6.152 APE9-dist-in 3.985 None None None XRAY 2.92 0.222 0.253 A 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo Homo sapiens AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOB P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.469 12.921 BLAminus -147.57, -176.88 49.48, 66.09 -89.42, 43.68 283.74, 78.16 -61.9, -48.01 in-in in 8.429 Saltbr-in 2.859 HRD-in -67.89, -44.49 63.77, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 138.67 APE9-dihe-na 143.94, 179.93 APE8-dihe-in -100.37, 135.53 APE8-rot-in 311.67 APE67-dihe-inflip 96.9, -39.59 -38.27, 126.0 APE12-dist-in 10.148 APE11-dist-in 11.731 APE10-dist-in 5.96 APE9-dist-in 3.734 None None None XRAY 2.92 0.222 0.253 B 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo Homo sapiens AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
CAMK AURKA AURKA_HUMAN 6VPMA O14965 7 389 403.0 AMP:60602,R74:60603 ATPlike,Allosteric Inactive DFGin 5.511 15.785 BLAminus -126.3, 179.56 64.46, 79.19 -94.31, 22.45 283.25, 78.95 -62.44, -22.15 out-out out 10.465 Saltbr-out 4.632 HRD-in -82.12, -50.43 74.02, 3.7 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -94.21, -5.66 APE9-dihe-na -50.93, -40.67 APE8-dihe-in -122.63, 120.42 APE8-rot-out 167.52 APE67-dihe-in -61.47, -28.56 -78.55, -11.77 APE12-dist-out 25.847 APE11-dist-out 21.306 APE10-dist-out 23.19 APE9-dist-out 28.096 None TPO288 TPO288 XRAY 1.58 0.17 0.203 A 292 262 4 0 0 4 [[133, 383]] 1.0 6vpm Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPMB O14965 7 389 403.0 AMP:60601,R74:60602 ATPlike,Allosteric Inactive DFGin 5.618 16.171 BLAminus -126.47, 179.26 64.24, 79.8 -93.68, 23.42 285.18, 79.92 -68.14, -17.47 out-out out 10.727 Saltbr-out 4.785 HRD-in -77.29, -52.49 74.53, -0.08 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.93, -6.99 APE9-dihe-na -61.27, -34.46 APE8-dihe-in -116.01, 94.69 APE8-rot-in 318.22 APE67-dihe-in -54.76, -31.62 -74.36, -14.23 APE12-dist-out 26.016 APE11-dist-out 21.519 APE10-dist-out 23.63 APE9-dist-out 28.431 None TPO288 TPO288 XRAY 1.58 0.17 0.203 B 292 262 4 0 0 4 [[133, 383]] 1.0 6vpm Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.177 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.881 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.708 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285 256 12 0 0 12 [[133, 383]] 1.0 9guc Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CASK CSKP_HUMAN 3C0HA O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.602 15.272 BLAminus -127.83, -151.84 62.45, 48.02 -88.8, 12.97 279.71, 88.33 -53.45, -27.37 in-in in 9.984 Saltbr-in 3.32 HRD-in -71.81, -47.22 72.01, -10.53 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.88, 145.94 APE9-dihe-na 100.98, -162.69 APE8-dihe-in -107.97, 118.32 APE8-rot-in 308.41 APE67-dihe-in -60.72, -23.96 -42.45, -43.89 APE12-dist-in 13.036 APE11-dist-in 12.314 APE10-dist-in 6.82 APE9-dist-in 3.701 None None None XRAY 2.3 0.191 0.239 A 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3C0HB O14936 5 304 926.0 AMP:338 ATPlike Pseudo DFGin 7.6 15.203 BLAminus -120.68, -148.62 53.86, 55.42 -94.09, 23.7 283.84, 83.03 -57.86, -26.99 in-in in 9.535 Saltbr-in 3.011 HRD-in -71.85, -49.31 73.45, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.66, 151.11 APE9-dihe-na 98.76, -158.5 APE8-dihe-in -113.67, 120.11 APE8-rot-in 310.97 APE67-dihe-in -61.76, -24.04 -43.49, -43.68 APE12-dist-in 12.992 APE11-dist-in 12.203 APE10-dist-in 6.64 APE9-dist-in 3.716 None None None XRAY 2.3 0.191 0.239 B 351 300 0 0 0 0 [[12, 276]] 1.0 3c0h Homo sapiens CAMK_CASK_HUMAN CAMK 6.3e-82 280.7 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK PIM1 PIM1_HUMAN 1YXUA P11309 33 305 313.0 AMP:550 ATPlike Active DFGin 6.045 14.58 BLAminus -128.48, 170.01 62.85, 77.77 -90.35, 20.24 287.6, 77.99 -74.7, 1.63 in-in in 8.513 Saltbr-in 2.486 HRD-na-A -60.24, -50.74 67.33, 4.52 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.18, 25.46 APE9-dihe-na -90.91, -158.18 APE8-dihe-in -86.5, 120.86 APE8-rot-in 310.09 APE67-dihe-in -63.06, -9.2 -60.21, -45.83 APE12-dist-in 9.959 APE11-dist-in 8.835 APE10-dist-in 5.689 APE9-dist-in 3.869 None None None XRAY 2.24 0.231 0.276 A 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUB P11309 33 305 313.0 AMP:650 ATPlike Active DFGin 6.12 14.673 BLAminus -120.37, 167.93 65.74, 85.44 -95.36, 14.03 285.37, 78.45 -64.71, -9.22 in-in in 8.6 Saltbr-in 2.814 HRD-na-A -59.51, -51.25 68.06, 6.92 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.12, 36.18 APE9-dihe-na -84.74, -152.35 APE8-dihe-in -93.27, 122.65 APE8-rot-in 302.12 APE67-dihe-in -68.21, -7.03 -55.31, -45.11 APE12-dist-in 9.8 APE11-dist-in 8.534 APE10-dist-in 5.457 APE9-dist-in 3.841 None None None XRAY 2.24 0.231 0.276 B 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUC P11309 34 305 313.0 AMP:750 ATPlike Active DFGin 6.11 14.741 BLAminus -134.94, 167.86 62.59, 83.1 -95.62, 21.45 280.06, 80.63 -81.83, 7.92 in-in in 8.716 Saltbr-in 2.612 HRD-na-A -67.31, -48.53 67.93, 5.85 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.01, 44.98 APE9-dihe-na -103.92, -155.25 APE8-dihe-in -86.11, 117.99 APE8-rot-in 310.09 APE67-dihe-in -68.22, -9.23 -52.45, -45.39 APE12-dist-in 9.697 APE11-dist-in 8.654 APE10-dist-in 5.604 APE9-dist-in 3.847 None None None XRAY 2.24 0.231 0.276 C 293 272 0 0 0 0 [[38, 290]] 1.0 1yxu Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUD P11309 33 305 313.0 AMP:850 ATPlike Active DFGin 6.236 14.556 BLAminus -126.04, 169.08 67.7, 73.28 -88.52, 13.94 289.01, 78.99 -70.28, -2.85 in-in in 8.789 Saltbr-in 2.466 HRD-na-A -64.06, -51.29 66.47, 10.4 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.8, 31.82 APE9-dihe-na -93.66, -159.09 APE8-dihe-in -85.99, 118.35 APE8-rot-in 303.12 APE67-dihe-in -71.66, -13.36 -52.91, -39.75 APE12-dist-in 9.896 APE11-dist-in 8.645 APE10-dist-in 5.457 APE9-dist-in 3.827 None None None XRAY 2.24 0.231 0.276 D 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CK1 CSNK1D KC1D_HUMAN 7P7FA P48730 3 294 415.0 AMP:305 ATPlike Active DFGin 6.386 14.989 BLAminus -135.41, 179.24 65.29, 82.6 -99.51, 20.86 287.48, 77.77 -56.63, -36.85 in-in in 8.099 Saltbr-in 2.591 HRD-in -82.17, -51.93 74.76, 11.47 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.01, 118.96 APE9-dihe-na 109.81, -163.5 APE8-dihe-in -91.97, 119.49 APE8-rot-in 320.94 APE67-dihe-in -55.9, -38.32 -51.55, -37.41 APE12-dist-in 13.114 APE11-dist-in 12.585 APE10-dist-in 6.845 APE9-dist-in 3.948 None TPO220 TPO220 XRAY 1.96 0.19 0.221 A 296 292 0 0 0 0 [[9, 275]] 1.0 7p7f Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FB P48730 3 294 415.0 AMP:310 ATPlike Active DFGin 6.389 15.041 BLAminus -134.9, -178.65 62.6, 84.78 -99.93, 21.19 288.23, 78.97 -57.89, -34.16 in-in in 8.117 Saltbr-in 2.593 HRD-in -86.23, -54.05 76.65, 11.34 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.84, 118.88 APE9-dihe-na 108.83, -162.51 APE8-dihe-in -93.95, 118.29 APE8-rot-in 320.41 APE67-dihe-in -55.93, -38.53 -50.49, -37.42 APE12-dist-in 13.14 APE11-dist-in 12.546 APE10-dist-in 6.804 APE9-dist-in 4.014 None TPO220 TPO220 XRAY 1.96 0.19 0.221 B 296 292 0 0 0 0 [[9, 275]] 1.0 7p7f Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7GA P48730 8 294 415.0 AMP:303 ATPlike Inactive DFGin 6.503 15.21 BLAminus -125.58, -175.5 62.42, 84.62 -97.89, 21.28 284.93, 73.84 -62.65, -25.46 in-in in 8.252 Saltbr-in 3.016 HRD-in -80.32, -51.03 68.77, 15.13 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -121.17, 158.18 APE9-dihe-na 70.26, -143.4 APE8-dihe-in -92.54, 123.25 APE8-rot-out 48.69 APE67-dihe-in -52.86, -40.08 -97.14, -14.35 APE12-dist-out 14.057 APE11-dist-in 12.931 APE10-dist-out 9.429 APE9-dist-out 8.015 None TPO220 TPO220 XRAY 1.7 0.173 0.208 A 296 287 0 0 0 0 [[9, 275]] 1.0 7p7g Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7GB P48730 7 293 415.0 AMP:307 ATPlike Inactive DFGin 6.484 14.825 BLAminus -126.09, 178.73 70.29, 86.32 -102.39, 14.25 288.72, 93.03 -61.48, -28.95 in-in in 8.084 Saltbr-in 3.028 HRD-in -71.5, -47.28 67.0, 16.77 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -110.74, 162.01 APE9-dihe-na -98.48, -144.78 APE8-dihe-in -45.03, 124.48 APE8-rot-out 164.69 APE67-dihe-in -57.08, -42.44 -74.38, -40.7 APE12-dist-in 7.209 APE11-dist-out 6.613 APE10-dist-out 8.393 APE9-dist-in 3.884 None TPO220 TPO220 XRAY 1.7 0.173 0.208 B 296 283 2 0 0 0 [[9, 275]] 1.0 7p7g Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HA P48730 3 294 415.0 AMP:301 ATPlike Active DFGin 5.85 14.904 BLAminus -131.69, 175.32 69.71, 86.46 -98.17, 29.2 291.07, 84.43 -61.3, -36.51 in-in in 8.328 Saltbr-in 2.869 HRD-in -85.02, -56.99 74.97, 14.35 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.26, -19.24 APE9-dihe-na -88.34, -159.24 APE8-dihe-in -92.63, 127.36 APE8-rot-in 313.8 APE67-dihe-in -57.88, -32.21 -74.29, -29.96 APE12-dist-in 10.816 APE11-dist-in 12.399 APE10-dist-in 6.988 APE9-dist-in 4.101 None None None XRAY 2.4 0.225 0.268 A 296 292 0 0 0 0 [[9, 275]] 1.0 7p7h Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HB P48730 3 294 415.0 AMP:301 ATPlike Active DFGin 5.843 14.916 BLAminus -130.5, 174.9 69.57, 86.72 -100.58, 28.91 292.34, 82.14 -57.01, -35.01 in-in in 8.325 Saltbr-in 2.918 HRD-in -84.55, -57.9 81.6, 9.08 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.93, 49.41 APE9-dihe-na 140.08, -131.01 APE8-dihe-in -99.84, 119.2 APE8-rot-in 321.52 APE67-dihe-in -56.55, -33.9 -75.78, -27.7 APE12-dist-in 12.421 APE11-dist-in 12.165 APE10-dist-in 7.215 APE9-dist-in 4.736 None None None XRAY 2.4 0.225 0.268 B 296 292 0 0 0 0 [[9, 275]] 1.0 7p7h Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 4IMYC P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.789 15.123 BLAminus -140.61, 175.84 60.41, 77.79 -97.02, 19.01 284.69, 80.72 -68.98, -8.54 in-in in 9.232 Saltbr-in 2.833 HRD-in -67.68, -50.97 65.16, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.81, 161.81 APE9-dihe-na 73.71, 135.92 APE8-dihe-in -53.34, 141.57 APE8-rot-in 294.85 APE67-dihe-in -61.16, -25.06 -47.9, -50.46 APE12-dist-in 13.386 APE11-dist-in 11.431 APE10-dist-in 7.006 APE9-dist-in 3.279 None TPO186 TPO186 XRAY 2.94 0.209 0.245 C 332 311 12 0 0 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4IMYE P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.794 15.112 BLAminus -141.41, 175.75 59.75, 77.9 -96.66, 19.65 284.44, 80.03 -69.65, -8.18 in-in in 9.197 Saltbr-in 2.816 HRD-in -68.02, -51.11 68.06, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.97, 161.65 APE9-dihe-na 74.14, 135.63 APE8-dihe-in -53.23, 140.74 APE8-rot-in 294.81 APE67-dihe-in -59.86, -25.62 -47.7, -50.88 APE12-dist-in 13.405 APE11-dist-in 11.437 APE10-dist-in 7.01 APE9-dist-in 3.278 None TPO186 TPO186 XRAY 2.94 0.209 0.245 E 332 314 9 0 0 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CDK9 CDK9_HUMAN 4IMYA P50750 8 330 372.0 AMP:401 Type1.5_Back Active DFGin 6.761 15.126 BLAminus -140.16, 177.94 57.41, 78.2 -96.63, 19.81 285.27, 81.22 -68.88, -9.41 in-in in 9.227 Saltbr-in 2.849 HRD-in -67.2, -51.3 65.19, 13.63 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 161.25 APE9-dihe-na 74.17, 135.57 APE8-dihe-in -52.35, 140.79 APE8-rot-in 295.69 APE67-dihe-in -60.8, -24.95 -48.08, -50.31 APE12-dist-in 13.39 APE11-dist-in 11.433 APE10-dist-in 7.009 APE9-dist-in 3.27 None TPO186 TPO186 XRAY 2.94 0.209 0.245 A 332 315 8 0 0 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC MAPK10 MK10_HUMAN 4KKEA P53779 45 400 464.0 AMP:501 ATPlike Inactive DFGin 3.889 14.134 ABAminus -83.98, -33.4 -131.72, 175.68 -114.08, 11.08 302.89, 82.85 75.62, -152.87 in-out in 9.705 Saltbr-out 5.629 HRD-in -71.56, -61.65 73.66, -1.84 out-out-out SNCooo out-out ActLoopNT-out 5.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -98.43, 129.33 APE9-dihe-na -82.63, 139.65 APE8-dihe-in -89.17, 118.02 APE8-rot-in 308.05 APE67-dihe-in -54.19, -24.02 -104.28, -7.92 APE12-dist-out 21.356 APE11-dist-out 16.314 APE10-dist-out 17.192 APE9-dist-out 11.507 None None None XRAY 2.2 0.233 0.291 A 365 354 2 0 0 2 [[64, 359]] 1.0 4kke Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK9 MK09_HUMAN 7N8TA P45984 10 364 424.0 AMP:401 ATPlike Inactive DFGin 4.063 14.828 ABAminus -84.92, -27.07 -147.51, 174.64 -99.27, 14.32 294.67, 92.77 76.31, -156.58 in-out in 9.829 Saltbr-out 6.299 HRD-in -68.91, -54.33 71.52, -2.96 out-out-out SNCooo out-out ActLoopNT-out 6.256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -98.36, 119.43 APE9-dihe-na -82.83, -52.5 APE8-dihe-in -95.69, 109.67 APE8-rot-in 308.73 APE67-dihe-in -71.55, -16.34 -115.42, 5.92 APE12-dist-in 9.622 APE11-dist-in 13.952 APE10-dist-out 10.595 APE9-dist-out 11.989 None None None XRAY 1.69 0.192 0.22 A 355 355 0 0 0 0 [[26, 321]] 1.0 7n8t Homo sapiens CMGC_MAPK9_HUMAN CMGC 7.5e-84 287.4 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
OTHER HASPIN HASP_HUMAN 3DLZA Q8TF76 470 798 798.0 AMP:902 ATPlike Active DFGin 5.254 12.469 BLAminus -120.14, 174.05 73.32, 91.07 -105.92, 29.14 315.79, 130.04 -57.27, -36.15 in-in in 9.264 Saltbr-in 2.695 HRD-na-N -71.0, -49.07 68.99, 3.03 in-in-na SNCiia in-na ActLoopNT-in 2.821 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -122.28, 17.39 APE9-dihe-na -67.57, 157.85 APE8-dihe-na -149.51, 177.99 APE8-rot-na 58.52 APE67-dihe-na -159.03, 144.74 95.06, -6.22 APE12-dist-na 9.493 APE11-dist-na 13.466 APE10-dist-na 17.05 APE9-dist-na 12.819 None None None XRAY 1.85 0.167 0.216 A 357 329 0 0 0 0 [[484, 797]] 1.0 3dlz Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
TYR EGFR EGFR_HUMAN 6P8QB P00533 698 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.276 14.467 BLBplus -135.86, 166.31 67.07, 15.83 -64.3, 136.34 50.27, 96.09 85.52, -9.82 out-out out 13.54 Saltbr-out 13.7 HRD-in -74.24, -59.24 89.14, -20.92 out-out-none SNCoon out-none ActLoopNT-out 6.974 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.09 APE9-dihe-in -104.23, 113.6 APE8-dihe-in -82.27, 71.52 APE8-rot-na 22.76 APE67-dihe-in -69.35, -13.24 -58.74, -40.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.877 APE9-dist-in 7.993 T790M,V948R None None XRAY 1.9 0.169 0.195 B 327 300 10 0 0 10 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QC P00533 699 1014 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.309 14.59 BLBplus -130.27, 166.7 65.36, 18.32 -66.06, 140.33 49.17, 97.15 81.91, -12.21 out-out out 13.83 Saltbr-out 13.591 HRD-in -81.24, -59.54 87.32, -15.78 out-out-in SNCooi out-in ActLoopNT-out 6.911 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.57, 147.96 APE9-dihe-in -130.06, 156.46 APE8-dihe-in -83.94, 74.96 APE8-rot-na 27.22 APE67-dihe-in -70.93, -14.87 -56.96, -36.77 APE12-dist-na 16.927 APE11-dist-na 13.676 APE10-dist-na 14.094 APE9-dist-in 7.721 T790M,V948R None None XRAY 1.9 0.169 0.195 C 327 316 0 0 0 0 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QD P00533 700 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.367 14.316 BLBplus -131.89, 166.57 70.0, 15.99 -68.19, 140.48 43.77, 99.15 83.83, -10.13 out-out out 13.426 Saltbr-out 13.149 HRD-in -73.29, -58.03 87.0, -17.51 out-out-none SNCoon out-none ActLoopNT-out 6.894 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 92.37 APE8-dihe-in -76.46, 76.63 APE8-rot-na 30.25 APE67-dihe-in -71.2, -11.99 -56.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.449 T790M,V948R None None XRAY 1.9 0.169 0.195 D 327 296 12 0 0 12 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR RET RET_HUMAN 2IVTA P07949 703 1012 1114.0 AMP:63015 ATPlike Inactive DFGin 6.582 14.046 BLAminus -135.2, 176.38 61.74, 80.34 -103.81, 14.47 281.76, 90.09 -59.35, -34.21 in-in in 7.234 Saltbr-in 2.737 HRD-in -77.56, -43.39 78.85, -29.33 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.53, 33.76 APE9-dihe-in -110.13, 138.63 APE8-dihe-in -57.62, 135.06 APE8-rot-na 332.88 APE67-dihe-in -80.74, -4.59 -59.92, -27.73 APE12-dist-na 13.764 APE11-dist-na 9.424 APE10-dist-na 8.046 APE9-dist-in 5.596 None PTR905 PTR905 XRAY 2.6 0.187 0.249 A 314 286 21 0 0 0 [[724, 1007]] 1.0 2ivt Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 6NE7A P07949 705 1013 1114.0 AMP:61103 ATPlike Inactive DFGin 6.727 14.262 BLAminus -136.24, -174.2 57.88, 74.27 -97.52, 17.22 284.41, 79.78 -59.81, -27.59 in-in in 7.093 Saltbr-in 2.608 HRD-in -73.16, -50.61 79.87, -20.93 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.57, 19.09 APE9-dihe-in -87.06, 133.71 APE8-dihe-in -50.0, 126.08 APE8-rot-na 331.41 APE67-dihe-in -72.8, -6.12 -42.6, -44.71 APE12-dist-na 13.52 APE11-dist-na 9.107 APE10-dist-na 7.618 APE9-dist-in 5.218 G810A PTR900,PTR905 PTR900,PTR905 XRAY 1.99 0.206 0.249 A 314 290 19 0 0 0 [[724, 1007]] 1.0 6ne7 Homo sapiens TYR_RET_HUMAN TYR 7.8e-100 339.4 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
AGC PRKACA KAPCA_MOUSE 1BKXA P05132 13 351 351.0 AMP:60351 ATPlike Active DFGin 6.16 13.915 BLAminus -117.09, 179.26 61.99, 75.16 -83.18, 21.65 286.96, 82.43 -60.51, -17.53 in-in in 8.724 Saltbr-in 2.658 HRD-in -99.39, -38.31 69.2, -9.22 in-in-in SNCiii in-in ActLoopNT-in 3.468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.44, 150.62 APE9-dihe-na 113.99, 166.84 APE8-dihe-in -65.88, 134.1 APE8-rot-in 334.22 APE67-dihe-in -70.66, -34.65 -48.92, -27.08 APE12-dist-in 8.284 APE11-dist-in 11.351 APE10-dist-in 5.704 APE9-dist-in 4.285 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.6 0.219 0.34 A 350 339 0 0 0 0 [[44, 298]] 1.0 1bkx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK DAPK2 DAPK2_MOUSE 2YABA Q8VDF3 13 311 370.0 AMP:61302 ATPlike Active DFGin 6.504 14.098 BLAminus -124.73, -175.5 61.61, 83.44 -98.66, 29.53 280.86, 70.25 -68.26, -23.3 in-in in 9.084 Saltbr-in 2.894 HRD-in -75.19, -47.84 69.74, 6.94 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.38, -177.82 APE9-dihe-na 87.95, 171.12 APE8-dihe-in -92.08, 123.94 APE8-rot-in 301.03 APE67-dihe-in -53.06, -29.06 -44.13, -47.2 APE12-dist-in 8.535 APE11-dist-in 11.604 APE10-dist-in 6.372 APE9-dist-in 4.88 None None None XRAY 1.9 0.174 0.215 A 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_MOUSE 2YABB Q8VDF3 13 311 370.0 AMP:61302 ATPlike Inactive DFGin 6.468 14.474 BLAminus -120.72, 178.3 68.63, 85.28 -101.56, 30.58 281.66, 69.64 -64.58, -26.78 in-out in 9.898 Saltbr-out 4.586 HRD-in -74.81, -49.22 70.61, 7.92 out-in-in SNCoii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.8, 177.85 APE9-dihe-na 92.04, 167.03 APE8-dihe-in -90.83, 122.42 APE8-rot-in 298.95 APE67-dihe-in -52.33, -27.71 -45.36, -46.31 APE12-dist-in 8.647 APE11-dist-in 11.618 APE10-dist-in 6.351 APE9-dist-in 4.931 None None None XRAY 1.9 0.174 0.215 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CMGC MPS1 MPS1_PYROR 8ZTCA O13352 5 408 415.0 AMP:501 ATPlike Inactive DFGin 6.292 15.514 BLAminus -144.74, 179.43 66.37, 92.96 -106.18, 19.45 287.11, 92.8 -68.03, -17.22 in-out in 9.653 Saltbr-out 3.698 HRD-in -72.95, -52.12 82.13, -5.81 out-in-out SNCoio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -105.16, 142.11 APE9-dihe-na -77.69, 172.27 APE8-dihe-in -67.55, 129.67 APE8-rot-in 314.62 APE67-dihe-in -66.25, -22.44 -63.55, -38.95 APE12-dist-in 7.03 APE11-dist-out 5.951 APE10-dist-out 9.549 APE9-dist-in 4.538 None None None XRAY 2.26 0.199 0.252 A 426 371 0 0 0 0 [[23, 314]] 1.0 8ztc Pyricularia oryzae CMGC_MPS1_PYROR CMGC 1.6e-78 270.0 1 301 301 166 167 168 170 172 52 70 74 146 148 147 149 211 198 193 192 191 190 189 188 187 105 Mitogen-activated protein kinase MPS1
OTHER BUD32 BUD32_YEAST 4WW7A P53323 4 257 261.0 AMP:301 ATPlike Active DFGin 6.607 15.107 BLAminus -125.65, 168.23 67.12, 79.12 -101.96, 21.21 282.36, 92.63 -52.39, -37.98 in-in in 7.952 Saltbr-in 3.029 HRD-in -80.86, -48.82 95.12, -20.58 in-in-na SNCiia in-na ActLoopNT-in 2.886 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.64, -46.2 APE9-dihe-na -61.22, -39.41 APE8-dihe-na -68.4, -38.62 APE8-rot-na 171.99 APE67-dihe-na -60.22, -42.81 -57.37, -50.5 APE12-dist-na 15.675 APE11-dist-na 11.246 APE10-dist-na 14.76 APE9-dist-na 11.687 None None None XRAY 1.669 0.194 0.213 A 261 237 21 0 0 0 [[17, 261]] 1.0 4ww7 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
CMGC ACK2 CSK2A_MAIZE 1DS5A P28523 1 328 332.0 AMP:60501 ATPlike Active DFGin 7.256 16.138 BLAminus -131.0, -177.8 59.5, 94.79 -110.09, 23.49 292.94, 70.46 -65.1, -12.46 in-in in 9.41 Saltbr-in 2.992 HRD-in -75.82, -4.13 22.93, 18.86 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, -170.21 APE9-dihe-na 48.23, -163.7 APE8-dihe-in -120.52, 135.99 APE8-rot-in 299.66 APE67-dihe-in -32.14, -36.61 -18.26, -83.73 APE12-dist-in 12.442 APE11-dist-in 10.293 APE10-dist-in 6.391 APE9-dist-in 3.166 None None None XRAY 3.16 0.214 0.289 A 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1DS5B P28523 1 328 332.0 AMP:60801 ATPlike Active DFGin 7.364 16.317 BLAminus -130.6, -175.34 56.5, 69.06 -85.22, 18.36 296.09, 73.67 -62.25, -12.27 in-in in 9.134 Saltbr-in 2.468 HRD-in -78.74, -8.85 28.88, 23.14 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.31, -172.94 APE9-dihe-na 48.86, -163.66 APE8-dihe-in -122.01, 142.21 APE8-rot-in 298.66 APE67-dihe-in -27.41, -40.26 -18.35, -90.48 APE12-dist-in 12.513 APE11-dist-in 10.354 APE10-dist-in 6.441 APE9-dist-in 3.101 None None None XRAY 3.16 0.214 0.289 B 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1DS5C P28523 1 328 332.0 AMP:60601 ATPlike Active DFGin 7.431 16.3 BLAminus -130.04, -171.91 47.17, 91.25 -104.25, 20.64 295.37, 72.57 -63.12, -7.55 in-in in 9.164 Saltbr-in 2.64 HRD-in -79.02, -3.04 26.4, 20.9 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.73, -170.98 APE9-dihe-na 48.52, -163.45 APE8-dihe-in -120.17, 138.04 APE8-rot-in 300.76 APE67-dihe-in -34.03, -36.56 -18.28, -84.34 APE12-dist-in 12.439 APE11-dist-in 10.299 APE10-dist-in 6.441 APE9-dist-in 3.093 None None None XRAY 3.16 0.214 0.289 C 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1DS5D P28523 1 328 332.0 AMP:60701 ATPlike Active DFGin 7.269 16.174 BLAminus -138.27, -179.17 62.24, 74.19 -94.05, 17.43 296.9, 73.95 -62.87, -11.79 in-in in 9.511 Saltbr-in 2.483 HRD-in -81.25, -4.13 24.81, 26.82 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.11, -172.61 APE9-dihe-na 51.23, -160.96 APE8-dihe-in -124.78, 137.86 APE8-rot-in 294.35 APE67-dihe-in -36.36, -34.26 -18.24, -83.45 APE12-dist-in 12.473 APE11-dist-in 10.246 APE10-dist-in 6.365 APE9-dist-in 3.133 None None None XRAY 3.16 0.214 0.289 D 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha

Ligand: AMP

Total number of chains: 20
Active chains: 13
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 85.0% 6ESAA
DFGin BLBplus 2 10.0% 4Y5QA
DFGin BLBminus 1 5.0% 3GC0A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QA A0A1D8PUA2 4 333 335.0 AMP:401 ATPlike Active DFGin 7.386 16.256 BLAminus -114.24, -174.82 59.27, 62.07 -85.23, 23.85 304.56, 80.46 -69.03, -20.65 in-in in 9.001 Saltbr-in 2.88 HRD-in -68.75, -45.06 62.13, 23.87 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.59, 173.17 APE9-dihe-na 57.84, -166.47 APE8-dihe-in -122.64, 160.2 APE8-rot-in 318.49 APE67-dihe-in -66.36, -14.81 -53.74, -47.77 APE12-dist-in 12.507 APE11-dist-in 10.219 APE10-dist-in 6.094 APE9-dist-in 3.225 None None None XRAY 2.7 0.236 0.287 A 335 326 4 0 0 0 [[43, 327]] 1.0 6o6q Candida albicans CMGC_CKA1_CANAL CMGC 1.1e-62 217.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 Casein kinase II subunit alpha
CMGC CKA1 A0A1D8PUA2_CANAL 6O6QB A0A1D8PUA2 5 333 335.0 AMP:401 ATPlike Active DFGin 7.292 15.98 BLAminus -125.13, -179.74 57.94, 64.68 -85.91, 27.32 303.1, 76.17 -70.46, -30.29 in-in in 9.011 Saltbr-in 2.813 HRD-in -81.71, -46.62 63.63, 27.36 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.56, 167.57 APE9-dihe-na 58.76, -171.72 APE8-dihe-in -113.79, 160.74 APE8-rot-in 318.5 APE67-dihe-in -64.2, -12.3 -53.09, -54.06 APE12-dist-in 12.689 APE11-dist-in 10.132 APE10-dist-in 6.255 APE9-dist-in 3.214 None None None XRAY 2.7 0.236 0.287 B 335 325 4 0 0 0 [[43, 327]] 1.0 6o6q Candida albicans CMGC_CKA1_CANAL CMGC 1.1e-62 217.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 Casein kinase II subunit alpha
AGC PRKACA KAPCA_CRIGR 6EH2A P25321 1 351 351.0 AMP:60401 ATPlike None DFGin 6.764 14.919 BLAminus -126.18, 164.33 76.56, 92.11 -105.87, 26.81 282.23, 79.7 -66.18, -22.24 in-none in 9.226 Saltbr-none 999.0 HRD-in -87.75, -53.65 70.54, 10.24 none-in-in SNCnii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.34, 158.08 APE9-dihe-na 131.59, -168.87 APE8-dihe-in -114.41, 135.93 APE8-rot-in 298.36 APE67-dihe-in -58.8, -22.41 -48.5, -50.6 APE12-dist-in 8.204 APE11-dist-in 11.426 APE10-dist-in 5.845 APE9-dist-in 3.719 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.76 0.177 0.21 A 353 343 3 0 0 0 [[44, 298]] 1.0 6eh2 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ESAA P25321 11 351 351.0 AMP:60401 ATPlike Active DFGin 6.139 14.365 BLAminus -120.63, 169.73 70.22, 89.96 -100.72, 24.5 270.85, 56.09 -58.05, -28.66 in-in in 8.691 Saltbr-in 2.873 HRD-in -93.01, -53.86 73.79, 10.3 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.44, 160.95 APE9-dihe-na 124.73, -163.46 APE8-dihe-in -117.05, 136.25 APE8-rot-in 299.26 APE67-dihe-in -59.89, -22.61 -49.24, -49.61 APE12-dist-in 8.091 APE11-dist-in 11.499 APE10-dist-in 5.822 APE9-dist-in 3.66 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.307 0.132 0.147 A 353 341 0 0 0 0 [[44, 298]] 1.0 6esa Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK CDPK1 A3FQ16_CRYPI 4Y5QA A3FQ16 70 537 538.0 AMP:60605 ATPlike Inactive DFGin 6.637 13.313 BLBplus -122.31, 173.29 68.1, 63.18 -158.9, 162.15 65.79, 84.8 99.05, -5.3 out-out out 13.961 Saltbr-out 15.153 HRD-in -71.3, -60.7 96.16, -22.83 out-out-out SNCooo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -93.85, 128.76 APE9-dihe-na 87.94, -2.34 APE8-dihe-out -58.24, -34.23 APE8-rot-out 195.73 APE67-dihe-in -60.61, -30.52 -58.8, -23.01 APE12-dist-out 20.841 APE11-dist-out 16.757 APE10-dist-out 22.574 APE9-dist-out 12.912 None None None XRAY 2.0 0.185 0.23 A 486 445 3 0 0 3 [[76, 332]] 1.0 4y5q Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.4e-90 308.1 1 256 256 218 219 220 222 224 105 123 127 195 197 196 198 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
CAMK CDPK1 A3FQ16_CRYPI 9D8SA A3FQ16 70 532 538.0 AMP:60601 ATPlike Inactive DFGin 6.46 13.578 BLBplus -128.41, 175.33 67.41, 57.43 -151.12, 166.1 65.63, 83.45 93.31, -10.38 out-out out 14.211 Saltbr-out 11.701 HRD-in -69.48, -54.89 79.68, -12.65 out-out-out SNCooo out-out ActLoopNT-out 8.836 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -57.81, -43.02 APE9-dihe-na -64.02, -42.45 APE8-dihe-out -59.86, -31.42 APE8-rot-in 285.42 APE67-dihe-in -59.31, -25.74 -61.84, -33.7 APE12-dist-out 17.325 APE11-dist-out 17.991 APE10-dist-out 22.08 APE9-dist-out 11.468 None None None XRAY 2.12 0.21 0.243 A 492 413 3 0 0 0 [[76, 332]] 1.0 9d8s Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.5e-90 308.1 1 256 256 218 219 220 222 224 105 123 127 195 197 196 198 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
OTHER PK1 A0A097P1P8_GVCP 6VVGA A0A097P1P8 3 279 279.0 AMP:301 ATPlike Active DFGin 9.47 12.504 BLAminus -139.45, 174.39 59.11, 72.82 -82.01, 20.88 324.49, 136.4 -73.16, -16.8 na-na na 15.471 Saltbr-na 12.976 HRD-in -69.17, -49.37 73.82, 3.86 na-in-in SNCaii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.58, 157.03 APE9-dihe-na 90.57, -158.23 APE8-dihe-in -103.25, 120.97 APE8-rot-in 311.05 APE67-dihe-in -75.71, -2.76 -55.41, -39.8 APE12-dist-in 10.799 APE11-dist-in 12.039 APE10-dist-in 6.083 APE9-dist-in 4.885 None None None XRAY 2.01 0.195 0.225 A 279 267 10 0 0 0 [[17, 277]] 1.0 6vvg Cydia pomonella granulosis virus OTHER_PK1_GVCP CAMK 1.9e-45 161.2 8 256 249 159 160 161 163 165 49 62 66 138 140 139 141 195 183 178 177 176 175 174 173 172 92 PK-1
OTHER PK1 A0A097P1P8_GVCP 6VVGB A0A097P1P8 3 278 279.0 AMP:301 ATPlike Active DFGin 9.485 12.665 BLAminus -138.4, 172.21 59.64, 73.0 -83.58, 22.42 324.54, 137.78 -67.63, -19.86 na-na na 15.282 Saltbr-na 13.214 HRD-in -58.02, -51.7 78.84, -1.77 na-in-in SNCaii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.97, 161.51 APE9-dihe-na 88.81, -151.71 APE8-dihe-in -109.06, 113.8 APE8-rot-in 308.85 APE67-dihe-in -72.96, -2.91 -51.95, -43.87 APE12-dist-in 10.828 APE11-dist-in 12.169 APE10-dist-in 6.178 APE9-dist-in 4.697 None None None XRAY 2.01 0.195 0.225 B 279 264 12 0 0 0 [[17, 277]] 1.0 6vvg Cydia pomonella granulosis virus OTHER_PK1_GVCP CAMK 1.9e-45 161.2 8 256 249 159 160 161 163 165 49 62 66 138 140 139 141 195 183 178 177 176 175 174 173 172 92 PK-1
TYR SRC SRC_CHICK 3DQXA P00523 259 533 533.0 AMP:1 ATPlike Inactive DFGin 6.591 14.447 BLAminus -124.27, -171.6 57.64, 68.97 -90.49, 15.25 301.42, 90.85 -48.99, -35.86 in-out in 7.776 Saltbr-out 3.984 HRD-in -86.41, -47.88 81.53, -17.67 out-in-in SNCoii in-in ActLoopNT-in 2.914 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -145.12, 138.88 APE9-dihe-in -131.92, 130.75 APE8-dihe-in -51.07, 94.4 APE8-rot-na 337.62 APE67-dihe-in -71.42, -26.35 -38.43, -38.46 APE12-dist-na 6.86 APE11-dist-na 10.768 APE10-dist-na 12.059 APE9-dist-in 6.564 None None None XRAY 2.3 0.194 0.241 A 286 267 8 0 0 8 [[267, 518]] 1.0 3dqx Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3DQXB P00523 259 533 533.0 AMP:2 ATPlike Active DFGin 6.808 14.815 BLAminus -123.08, -167.74 51.93, 60.88 -81.23, 10.84 295.11, 95.49 -43.33, -48.19 in-in in 7.906 Saltbr-in 3.425 HRD-in -73.53, -53.77 83.73, -6.08 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.36, 128.73 APE9-dihe-in -122.57, 114.22 APE8-dihe-in -63.43, 112.38 APE8-rot-na 23.41 APE67-dihe-in -72.31, -17.76 -46.16, -42.59 APE12-dist-na 10.885 APE11-dist-na 6.755 APE10-dist-na 9.999 APE9-dist-in 5.75 None None None XRAY 2.3 0.194 0.241 B 286 268 7 0 0 7 [[267, 518]] 1.0 3dqx Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC CDK A8BZ95_GIAIC 3GC0A A8BZ95 11 308 308.0 AMP:309 ATPlike Inactive DFGin 10.734 18.123 BLBminus -99.74, 152.92 74.37, 22.26 -55.88, 137.45 246.69, 94.2 78.53, -11.24 out-none out 15.235 Saltbr-none 999.0 HRD-in -87.56, -59.97 77.29, -14.0 none-out-out SNCnoo out-out ActLoopNT-out 5.956 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nooo APE10-dihe-na -74.71, -16.76 APE9-dihe-na -60.85, -32.02 APE8-dihe-out -56.57, -42.85 APE8-rot-none 999.0 APE67-dihe-in -62.9, -23.58 -58.04, -33.64 APE12-dist-none 999.0 APE11-dist-out 17.469 APE10-dist-out 21.327 APE9-dist-out 11.763 None None None XRAY 2.0 0.199 0.265 A 329 278 20 0 0 9 [[15, 301]] 1.0 3gc0 Giardia intestinalis CMGC_CDK_GIAIC CMGC 1.5e-81 280.1 1 301 301 158 159 160 162 164 44 62 66 133 135 134 136 199 186 181 180 179 178 177 176 175 92 cyclin-dependent kinase
AGC PRKACA KAPCA_MOUSE 1BKXA P05132 13 351 351.0 AMP:60351 ATPlike Active DFGin 6.16 13.915 BLAminus -117.09, 179.26 61.99, 75.16 -83.18, 21.65 286.96, 82.43 -60.51, -17.53 in-in in 8.724 Saltbr-in 2.658 HRD-in -99.39, -38.31 69.2, -9.22 in-in-in SNCiii in-in ActLoopNT-in 3.468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.44, 150.62 APE9-dihe-na 113.99, 166.84 APE8-dihe-in -65.88, 134.1 APE8-rot-in 334.22 APE67-dihe-in -70.66, -34.65 -48.92, -27.08 APE12-dist-in 8.284 APE11-dist-in 11.351 APE10-dist-in 5.704 APE9-dist-in 4.285 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.6 0.219 0.34 A 350 339 0 0 0 0 [[44, 298]] 1.0 1bkx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK DAPK2 DAPK2_MOUSE 2YABA Q8VDF3 13 311 370.0 AMP:61302 ATPlike Active DFGin 6.504 14.098 BLAminus -124.73, -175.5 61.61, 83.44 -98.66, 29.53 280.86, 70.25 -68.26, -23.3 in-in in 9.084 Saltbr-in 2.894 HRD-in -75.19, -47.84 69.74, 6.94 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.38, -177.82 APE9-dihe-na 87.95, 171.12 APE8-dihe-in -92.08, 123.94 APE8-rot-in 301.03 APE67-dihe-in -53.06, -29.06 -44.13, -47.2 APE12-dist-in 8.535 APE11-dist-in 11.604 APE10-dist-in 6.372 APE9-dist-in 4.88 None None None XRAY 1.9 0.174 0.215 A 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_MOUSE 2YABB Q8VDF3 13 311 370.0 AMP:61302 ATPlike Inactive DFGin 6.468 14.474 BLAminus -120.72, 178.3 68.63, 85.28 -101.56, 30.58 281.66, 69.64 -64.58, -26.78 in-out in 9.898 Saltbr-out 4.586 HRD-in -74.81, -49.22 70.61, 7.92 out-in-in SNCoii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.8, 177.85 APE9-dihe-na 92.04, 167.03 APE8-dihe-in -90.83, 122.42 APE8-rot-in 298.95 APE67-dihe-in -52.33, -27.71 -45.36, -46.31 APE12-dist-in 8.647 APE11-dist-in 11.618 APE10-dist-in 6.351 APE9-dist-in 4.931 None None None XRAY 1.9 0.174 0.215 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yab Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CMGC MPS1 MPS1_PYROR 8ZTCA O13352 5 408 415.0 AMP:501 ATPlike Inactive DFGin 6.292 15.514 BLAminus -144.74, 179.43 66.37, 92.96 -106.18, 19.45 287.11, 92.8 -68.03, -17.22 in-out in 9.653 Saltbr-out 3.698 HRD-in -72.95, -52.12 82.13, -5.81 out-in-out SNCoio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -105.16, 142.11 APE9-dihe-na -77.69, 172.27 APE8-dihe-in -67.55, 129.67 APE8-rot-in 314.62 APE67-dihe-in -66.25, -22.44 -63.55, -38.95 APE12-dist-in 7.03 APE11-dist-out 5.951 APE10-dist-out 9.549 APE9-dist-in 4.538 None None None XRAY 2.26 0.199 0.252 A 426 371 0 0 0 0 [[23, 314]] 1.0 8ztc Pyricularia oryzae CMGC_MPS1_PYROR CMGC 1.6e-78 270.0 1 301 301 166 167 168 170 172 52 70 74 146 148 147 149 211 198 193 192 191 190 189 188 187 105 Mitogen-activated protein kinase MPS1
OTHER BUD32 BUD32_YEAST 4WW7A P53323 4 257 261.0 AMP:301 ATPlike Active DFGin 6.607 15.107 BLAminus -125.65, 168.23 67.12, 79.12 -101.96, 21.21 282.36, 92.63 -52.39, -37.98 in-in in 7.952 Saltbr-in 3.029 HRD-in -80.86, -48.82 95.12, -20.58 in-in-na SNCiia in-na ActLoopNT-in 2.886 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.64, -46.2 APE9-dihe-na -61.22, -39.41 APE8-dihe-na -68.4, -38.62 APE8-rot-na 171.99 APE67-dihe-na -60.22, -42.81 -57.37, -50.5 APE12-dist-na 15.675 APE11-dist-na 11.246 APE10-dist-na 14.76 APE9-dist-na 11.687 None None None XRAY 1.669 0.194 0.213 A 261 237 21 0 0 0 [[17, 261]] 1.0 4ww7 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
CMGC ACK2 CSK2A_MAIZE 1DS5A P28523 1 328 332.0 AMP:60501 ATPlike Active DFGin 7.256 16.138 BLAminus -131.0, -177.8 59.5, 94.79 -110.09, 23.49 292.94, 70.46 -65.1, -12.46 in-in in 9.41 Saltbr-in 2.992 HRD-in -75.82, -4.13 22.93, 18.86 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, -170.21 APE9-dihe-na 48.23, -163.7 APE8-dihe-in -120.52, 135.99 APE8-rot-in 299.66 APE67-dihe-in -32.14, -36.61 -18.26, -83.73 APE12-dist-in 12.442 APE11-dist-in 10.293 APE10-dist-in 6.391 APE9-dist-in 3.166 None None None XRAY 3.16 0.214 0.289 A 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1DS5B P28523 1 328 332.0 AMP:60801 ATPlike Active DFGin 7.364 16.317 BLAminus -130.6, -175.34 56.5, 69.06 -85.22, 18.36 296.09, 73.67 -62.25, -12.27 in-in in 9.134 Saltbr-in 2.468 HRD-in -78.74, -8.85 28.88, 23.14 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.31, -172.94 APE9-dihe-na 48.86, -163.66 APE8-dihe-in -122.01, 142.21 APE8-rot-in 298.66 APE67-dihe-in -27.41, -40.26 -18.35, -90.48 APE12-dist-in 12.513 APE11-dist-in 10.354 APE10-dist-in 6.441 APE9-dist-in 3.101 None None None XRAY 3.16 0.214 0.289 B 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1DS5C P28523 1 328 332.0 AMP:60601 ATPlike Active DFGin 7.431 16.3 BLAminus -130.04, -171.91 47.17, 91.25 -104.25, 20.64 295.37, 72.57 -63.12, -7.55 in-in in 9.164 Saltbr-in 2.64 HRD-in -79.02, -3.04 26.4, 20.9 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.73, -170.98 APE9-dihe-na 48.52, -163.45 APE8-dihe-in -120.17, 138.04 APE8-rot-in 300.76 APE67-dihe-in -34.03, -36.56 -18.28, -84.34 APE12-dist-in 12.439 APE11-dist-in 10.299 APE10-dist-in 6.441 APE9-dist-in 3.093 None None None XRAY 3.16 0.214 0.289 C 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1DS5D P28523 1 328 332.0 AMP:60701 ATPlike Active DFGin 7.269 16.174 BLAminus -138.27, -179.17 62.24, 74.19 -94.05, 17.43 296.9, 73.95 -62.87, -11.79 in-in in 9.511 Saltbr-in 2.483 HRD-in -81.25, -4.13 24.81, 26.82 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.11, -172.61 APE9-dihe-na 51.23, -160.96 APE8-dihe-in -124.78, 137.86 APE8-rot-in 294.35 APE67-dihe-in -36.36, -34.26 -18.24, -83.45 APE12-dist-in 12.473 APE11-dist-in 10.246 APE10-dist-in 6.365 APE9-dist-in 3.133 None None None XRAY 3.16 0.214 0.289 D 332 328 0 0 0 0 [[34, 319]] 1.0 1ds5 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha