AGC_ROCK1 (Rho-associated protein kinase 1)

Total number of chains: 78
Active chains: 22
Family: AGC
Uniprot: ROCK1_HUMAN
Kinase Domain Residues: 76 - 338
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 48 61.5% AF-Q13464-K1A
DFGin ABAminus 22 28.2% 5WNFA
DFGout None 3 3.8% 7S25B
DFGinter None 2 2.6% 3TWJB
DFGin BLBminus 1 1.3% 7S26C
DFGin None 1 1.3% 3TWJC
None None 1 1.3% 7S25D
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
2V55A 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.88 13.604 BLAminus -137.29, -177.31 60.22, 109.9 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.076 Saltbr-in 2.708 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.281 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.324 APE11-dist-in 11.278 APE10-dist-in 5.647 APE9-dist-in 4.131 None None None XRAY 3.705 0.238 0.269 A 406 393 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2V55C 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.884 13.608 BLAminus -137.56, -177.44 62.15, 108.48 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.247 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.28 APE11-dist-in 11.269 APE10-dist-in 5.623 APE9-dist-in 4.097 None None None XRAY 3.705 0.238 0.269 C 406 396 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AF-Q13464-K1A 68 346 1354.0 No_ligand No_ligand Active DFGin 6.006 13.066 BLAminus -137.66, -178.75 47.45, 69.34 -81.8, 16.56 305.27, 105.28 -65.56, -12.08 in-in in 8.552 Saltbr-in 2.624 HRD-in -74.85, -46.42 64.04, 4.32 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.58, 160.73 APE9-dihe-na 98.63, 175.06 APE8-dihe-in -68.34, 133.89 APE8-rot-in 288.19 APE67-dihe-in -75.11, -22.05 -52.44, -39.16 APE12-dist-in 10.159 APE11-dist-in 11.26 APE10-dist-in 5.393 APE9-dist-in 3.726 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K1 AGC_ROCK1_HUMAN AGC 9.2e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AF-Q13464-K3A 68 346 1354.0 No_ligand No_ligand Active DFGin 5.851 13.271 BLAminus -137.07, 179.96 52.49, 70.51 -80.48, 13.64 307.69, 107.27 -65.8, -8.31 in-in in 8.833 Saltbr-in 2.683 HRD-in -84.07, -47.73 66.69, 2.67 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.35, 143.29 APE9-dihe-na 121.73, 178.17 APE8-dihe-in -80.88, 131.47 APE8-rot-in 300.07 APE67-dihe-in -72.64, -15.78 -48.59, -46.75 APE12-dist-in 10.802 APE11-dist-in 11.642 APE10-dist-in 5.871 APE9-dist-in 3.256 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K3 AGC_ROCK1_HUMAN AGC 9.2e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4W7PA 6 405 1354.0 3J7:501 Type1 Active DFGin 6.259 12.978 BLAminus -131.32, -179.69 55.02, 77.47 -91.49, 17.42 302.12, 101.71 -69.96, -11.88 in-in in 8.182 Saltbr-in 2.566 HRD-in -62.73, -47.54 67.38, -1.52 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.79, 138.22 APE9-dihe-na 110.79, -174.17 APE8-dihe-in -93.29, 129.06 APE8-rot-in 302.8 APE67-dihe-in -74.33, -31.52 -36.7, -38.86 APE12-dist-in 10.731 APE11-dist-in 11.462 APE10-dist-in 5.952 APE9-dist-in 3.674 None None None XRAY 2.8 0.208 0.246 A 411 388 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4W7PB 6 401 1354.0 3J7:501 Type1 Active DFGin 6.154 13.435 BLAminus -133.96, 174.8 56.5, 83.88 -98.36, 33.02 302.17, 98.2 -70.04, -15.43 in-in in 8.214 Saltbr-in 2.726 HRD-in -62.94, -46.77 66.68, -0.73 in-in-in SNCiii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.83, 139.14 APE9-dihe-na 109.13, -172.67 APE8-dihe-in -92.68, 127.41 APE8-rot-in 302.74 APE67-dihe-in -74.45, -31.78 -35.08, -39.48 APE12-dist-in 10.707 APE11-dist-in 11.408 APE10-dist-in 5.883 APE9-dist-in 3.703 None None None XRAY 2.8 0.208 0.246 B 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4W7PC 6 401 1354.0 3J7:501 Type1 Active DFGin 6.282 13.256 BLAminus -124.31, 179.51 53.21, 87.62 -105.48, 23.02 305.5, 95.5 -67.24, -3.72 in-in in 8.257 Saltbr-in 2.797 HRD-in -62.84, -46.85 67.56, -2.48 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.95, 139.35 APE9-dihe-na 109.16, -174.28 APE8-dihe-in -91.11, 127.59 APE8-rot-in 304.22 APE67-dihe-in -73.68, -32.3 -37.14, -39.74 APE12-dist-in 10.725 APE11-dist-in 11.541 APE10-dist-in 6.024 APE9-dist-in 3.675 None None None XRAY 2.8 0.208 0.246 C 411 383 7 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4W7PD 6 403 1354.0 3J7:501 Type1 Active DFGin 6.352 13.321 BLAminus -140.19, -177.5 56.39, 77.39 -95.5, 16.8 300.98, 99.72 -61.76, -14.51 in-in in 8.291 Saltbr-in 2.836 HRD-in -63.87, -49.18 67.62, 4.17 in-in-in SNCiii in-in ActLoopNT-in 3.098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.12, 138.83 APE9-dihe-na 110.39, -175.06 APE8-dihe-in -91.75, 128.12 APE8-rot-in 303.98 APE67-dihe-in -75.08, -31.43 -35.22, -39.46 APE12-dist-in 10.68 APE11-dist-in 11.483 APE10-dist-in 5.932 APE9-dist-in 3.702 None None None XRAY 2.8 0.208 0.246 D 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2ESMA 6 405 1354.0 M77:60416 Type1 Active DFGin 6.105 13.688 BLAminus -120.74, 175.27 52.57, 92.93 -113.78, 23.07 302.86, 94.18 -55.5, -15.7 in-in in 8.584 Saltbr-in 2.762 HRD-in -64.55, -47.39 72.73, -12.37 in-in-in SNCiii in-in ActLoopNT-in 3.313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 156.73 APE9-dihe-na 129.25, -151.41 APE8-dihe-in -127.71, 135.99 APE8-rot-in 310.98 APE67-dihe-in -65.34, -28.12 -39.62, -57.01 APE12-dist-in 11.724 APE11-dist-in 11.453 APE10-dist-in 5.777 APE9-dist-in 3.535 None None None XRAY 3.2 0.245 0.269 A 415 400 0 0 0 0 [[76, 338]] 1.0 2esm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2ETKA 6 405 1354.0 HFS:60416 Type1 Active DFGin 6.059 14.097 BLAminus -116.57, 151.42 65.52, 106.25 -118.99, 38.28 303.23, 95.7 -62.53, -30.1 in-in in 9.024 Saltbr-in 3.087 HRD-in -67.16, -45.15 69.82, -9.8 in-in-in SNCiii in-in ActLoopNT-in 3.224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.46, 135.93 APE9-dihe-na 138.1, -153.58 APE8-dihe-in -121.49, 133.91 APE8-rot-in 318.16 APE67-dihe-in -78.08, -32.49 -44.0, -39.32 APE12-dist-in 11.84 APE11-dist-in 11.546 APE10-dist-in 5.856 APE9-dist-in 3.737 None None None XRAY 2.96 0.278 0.298 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etk AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2ETRA 6 405 1354.0 Y27:60416 Type1 Active DFGin 6.023 14.033 BLAminus -115.35, 151.29 66.22, 120.62 -135.54, 23.8 302.55, 92.69 -59.35, -26.34 in-in in 8.786 Saltbr-in 2.733 HRD-in -66.03, -45.85 73.19, -11.33 in-in-in SNCiii in-in ActLoopNT-in 3.095 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 135.12 APE9-dihe-na 138.18, -155.48 APE8-dihe-in -122.76, 133.42 APE8-rot-in 310.03 APE67-dihe-in -71.74, -29.22 -38.34, -50.83 APE12-dist-in 11.748 APE11-dist-in 11.548 APE10-dist-in 5.877 APE9-dist-in 3.701 None None None XRAY 2.6 0.252 0.266 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etr AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3D9VA 6 405 1354.0 H52:60416 Type1 Active DFGin 6.202 14.259 BLAminus -97.17, 154.71 64.91, 125.89 -137.95, 39.08 298.06, 99.68 -71.65, -6.65 in-in in 9.177 Saltbr-in 3.154 HRD-in -71.72, -45.61 70.74, -5.17 in-in-in SNCiii in-in ActLoopNT-in 3.202 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.18, 131.07 APE9-dihe-na 140.68, -156.12 APE8-dihe-in -114.86, 135.68 APE8-rot-in 311.45 APE67-dihe-in -80.47, -37.33 -48.71, -38.59 APE12-dist-in 11.746 APE11-dist-in 11.776 APE10-dist-in 6.137 APE9-dist-in 3.756 None None None XRAY 3.3 0.262 0.28 A 415 400 0 0 0 0 [[76, 338]] 1.0 3d9v AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4YVCA 6 405 1354.0 4KH:60501 Type1 Active DFGin 5.87 13.114 BLAminus -131.73, 179.43 49.79, 78.91 -95.58, 35.98 309.76, 96.36 -52.74, -39.15 in-in in 8.425 Saltbr-in 3.027 HRD-in -62.91, -47.72 78.09, -4.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.16, 137.86 APE9-dihe-na 126.1, -158.78 APE8-dihe-in -106.17, 145.81 APE8-rot-in 290.0 APE67-dihe-in -72.07, -14.66 -55.89, -48.56 APE12-dist-in 11.644 APE11-dist-in 11.414 APE10-dist-in 5.915 APE9-dist-in 3.809 None None None XRAY 3.2 0.193 0.221 A 415 388 5 0 0 0 [[76, 338]] 1.0 4yvc AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4YVEA 6 405 1354.0 4KK:60501 Type1 Active DFGin 5.621 12.807 BLAminus -135.63, 174.2 57.57, 62.47 -84.06, 54.44 321.53, 81.4 -64.54, -38.78 in-in in 8.392 Saltbr-in 2.839 HRD-in -66.81, -33.75 61.05, -11.49 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.37, 139.44 APE9-dihe-na 133.32, -156.65 APE8-dihe-in -109.47, 141.28 APE8-rot-in 300.76 APE67-dihe-in -87.71, -40.47 -52.3, -33.35 APE12-dist-in 11.916 APE11-dist-in 11.54 APE10-dist-in 6.006 APE9-dist-in 3.84 None None None XRAY 3.4 0.219 0.244 A 415 390 4 0 0 0 [[76, 338]] 1.0 4yve AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5BMLA 6 405 1354.0 4TW:60501 Type1 Active DFGin 6.166 13.115 BLAminus -136.45, -178.03 52.19, 80.38 -99.05, 18.0 302.5, 105.79 -59.89, -6.36 in-in in 8.173 Saltbr-in 2.761 HRD-in -66.74, -49.49 70.73, -5.79 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.01, 144.84 APE9-dihe-na 123.64, -151.58 APE8-dihe-in -116.7, 138.56 APE8-rot-in 292.02 APE67-dihe-in -71.41, -43.61 -45.01, -45.51 APE12-dist-in 12.171 APE11-dist-in 11.52 APE10-dist-in 6.047 APE9-dist-in 3.748 None None None XRAY 2.95 0.207 0.235 A 415 393 2 0 0 0 [[76, 338]] 1.0 5bml AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5KKSA 6 405 1354.0 6U1:60501 Type1 Active DFGin 6.186 13.352 BLAminus -142.64, 177.27 59.6, 62.04 -81.65, 21.26 304.3, 101.28 -54.79, -41.15 in-in in 8.259 Saltbr-in 2.754 HRD-in -54.42, -38.35 63.96, -11.55 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.2, 147.03 APE9-dihe-na 120.6, -151.04 APE8-dihe-in -115.4, 140.07 APE8-rot-in 299.71 APE67-dihe-in -59.58, -43.85 -44.15, -59.93 APE12-dist-in 11.887 APE11-dist-in 11.441 APE10-dist-in 5.829 APE9-dist-in 3.748 None None None XRAY 3.3 0.215 0.254 A 415 395 0 0 0 0 [[76, 338]] 1.0 5kks AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5KKTA 6 405 1354.0 6U2:60501 Type1 Active DFGin 6.335 13.585 BLAminus -128.59, -176.48 50.52, 79.42 -95.97, 17.69 299.29, 99.89 -62.82, -14.55 in-in in 8.893 Saltbr-in 2.772 HRD-in -67.63, -48.61 71.19, -4.25 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, 142.19 APE9-dihe-na 128.21, -142.04 APE8-dihe-in -128.93, 139.4 APE8-rot-in 303.92 APE67-dihe-in -73.59, -33.97 -48.22, -44.35 APE12-dist-in 11.474 APE11-dist-in 11.675 APE10-dist-in 6.173 APE9-dist-in 3.606 None None None XRAY 2.8 0.223 0.237 A 415 389 4 0 0 0 [[76, 338]] 1.0 5kkt AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5UZJA 6 405 1354.0 8UV:60501 Type1 Active DFGin 6.17 13.101 BLAminus -139.82, 174.8 51.53, 74.94 -94.18, 44.21 303.79, 97.11 -58.95, -59.6 in-in in 8.64 Saltbr-in 2.794 HRD-in -71.22, -41.37 70.75, -24.52 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.33, 135.82 APE9-dihe-na 134.09, -159.86 APE8-dihe-in -104.52, 140.59 APE8-rot-in 298.4 APE67-dihe-in -92.6, -25.3 -52.4, -27.33 APE12-dist-in 11.906 APE11-dist-in 11.503 APE10-dist-in 5.992 APE9-dist-in 4.031 None None None XRAY 3.3 0.202 0.241 A 415 387 8 0 0 0 [[76, 338]] 1.0 5uzj AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5HVUA 6 405 1354.0 65R:60501 Type1.5_Front Active DFGin 6.064 13.008 BLAminus -144.77, -177.33 55.22, 80.15 -106.17, 33.13 305.29, 103.88 -64.0, -11.53 in-in in 8.403 Saltbr-in 2.919 HRD-in -68.11, -52.8 76.77, -16.02 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 135.58 APE9-dihe-na 137.6, -151.11 APE8-dihe-in -124.0, 136.06 APE8-rot-in 298.85 APE67-dihe-in -72.28, -36.35 -46.39, -41.26 APE12-dist-in 12.022 APE11-dist-in 11.468 APE10-dist-in 5.929 APE9-dist-in 3.886 None None None XRAY 2.8 0.239 0.248 A 415 394 0 0 0 0 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNEA 14 400 1354.0 B4J:60501 Type1.5_Front Active DFGin 6.225 13.567 BLAminus -135.0, 175.35 53.04, 84.77 -102.97, 28.35 302.63, 101.99 -70.63, -10.88 in-in in 8.951 Saltbr-in 2.812 HRD-in -65.73, -50.65 71.21, -5.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 137.37 APE9-dihe-na 126.73, -152.59 APE8-dihe-in -112.81, 138.1 APE8-rot-in 304.24 APE67-dihe-in -78.8, -30.66 -52.66, -36.48 APE12-dist-in 10.985 APE11-dist-in 11.543 APE10-dist-in 5.882 APE9-dist-in 3.725 None None None XRAY 2.6 0.229 0.246 A 415 384 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNEC 6 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.226 13.312 BLAminus -141.6, 173.01 60.67, 84.57 -108.59, 26.04 304.33, 107.59 -71.96, -9.2 in-in in 8.556 Saltbr-in 2.815 HRD-in -53.88, -50.49 68.34, -4.44 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 131.39 APE9-dihe-na 141.47, -150.22 APE8-dihe-in -114.01, 135.26 APE8-rot-in 304.1 APE67-dihe-in -79.17, -28.35 -50.74, -38.29 APE12-dist-in 10.779 APE11-dist-in 11.589 APE10-dist-in 5.735 APE9-dist-in 3.822 None None None XRAY 2.6 0.229 0.246 C 415 382 9 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNED 7 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.109 13.38 BLAminus -136.38, 179.68 48.06, 76.76 -93.24, 35.49 302.92, 95.86 -65.45, -20.45 in-in in 8.487 Saltbr-in 2.785 HRD-in -58.19, -50.71 67.27, -4.18 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.61, 140.56 APE9-dihe-na 127.23, -150.56 APE8-dihe-in -113.66, 136.6 APE8-rot-in 304.03 APE67-dihe-in -77.29, -31.2 -52.52, -36.89 APE12-dist-in 10.389 APE11-dist-in 11.435 APE10-dist-in 5.778 APE9-dist-in 3.834 None None None XRAY 2.6 0.229 0.246 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NDMA 6 402 1354.0 No_ligand No_ligand Inactive DFGin 5.598 13.058 ABAminus -120.89, -34.04 -109.2, 148.34 -142.38, 4.69 304.49, 84.24 -63.88, 57.85 in-out in 9.076 Saltbr-out 3.763 HRD-in -57.38, -56.5 79.4, 26.69 out-in-in SNCoii in-in ActLoopNT-in 3.157 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.05, 156.15 APE9-dihe-na 131.42, -138.04 APE8-dihe-in -125.51, 139.35 APE8-rot-in 275.81 APE67-dihe-in -57.52, -0.48 -48.9, -63.05 APE12-dist-in 10.485 APE11-dist-in 11.171 APE10-dist-in 5.509 APE9-dist-in 4.003 None None None XRAY 3.3 0.244 0.31 A 415 382 11 0 0 0 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NCZA 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.335 13.775 ABAminus -116.14, -12.55 -138.55, 134.31 -126.47, 14.42 296.82, 87.82 -51.46, -39.63 in-in in 9.306 Saltbr-in 3.537 HRD-in -78.05, -50.28 73.4, -14.49 in-in-in SNCiii in-in ActLoopNT-in 3.161 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.89, -176.36 APE9-dihe-na 133.28, -167.86 APE8-dihe-in -125.48, 134.73 APE8-rot-in 280.08 APE67-dihe-in -84.68, -47.89 -24.91, -55.61 APE12-dist-in 12.595 APE11-dist-in 10.072 APE10-dist-in 5.448 APE9-dist-in 3.551 None None None XRAY 3.0 0.259 0.328 A 415 397 0 0 0 0 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NCZB 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.168 13.439 ABAminus -114.85, -16.66 -131.56, 138.9 -136.04, 17.21 298.24, 65.97 -58.26, -38.43 in-in in 9.313 Saltbr-in 2.492 HRD-in -79.75, -44.81 74.12, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -112.01 APE9-dihe-na -175.97, -67.78 APE8-dihe-in -149.88, 165.72 APE8-rot-out 209.54 APE67-dihe-in -50.79, -11.63 -86.98, -72.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.143 APE9-dist-in 4.977 None None None XRAY 3.0 0.259 0.328 B 415 377 15 0 0 2 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NCZC 6 404 1354.0 3NC:60900 Type1 Inactive DFGin 5.957 13.35 ABAminus -116.08, -7.73 -136.42, 136.67 -131.83, 24.74 306.96, 86.44 -58.54, -34.95 in-in in 9.223 Saltbr-in 3.491 HRD-in -83.49, -46.62 73.83, -20.27 in-in-in SNCiii in-in ActLoopNT-in 3.156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.05, 125.19 APE9-dihe-na 160.07, -158.87 APE8-dihe-in -144.7, 128.84 APE8-rot-in 311.05 APE67-dihe-in -25.99, -52.32 -21.36, -99.97 APE12-dist-in 10.188 APE11-dist-in 11.672 APE10-dist-in 5.728 APE9-dist-in 3.595 None None None XRAY 3.0 0.259 0.328 C 415 387 6 0 0 1 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NCZD 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.007 13.398 ABAminus -130.28, 7.59 -144.4, 127.27 -129.17, 19.34 304.27, 91.75 -57.04, -39.11 in-in in 9.214 Saltbr-in 3.563 HRD-in -74.16, -50.68 74.64, -10.85 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.26, 158.97 APE9-dihe-na 125.95, -146.31 APE8-dihe-in -122.54, 128.42 APE8-rot-in 314.26 APE67-dihe-in -57.68, -28.69 -36.8, -72.93 APE12-dist-in 12.398 APE11-dist-in 11.269 APE10-dist-in 6.343 APE9-dist-in 4.414 None None None XRAY 3.0 0.259 0.328 D 415 397 0 0 0 0 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NDMB 7 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.577 13.291 ABAminus -135.55, -20.22 -111.5, 137.71 -126.94, 16.16 300.9, 101.92 -51.55, 28.77 in-in in 9.054 Saltbr-in 3.139 HRD-in -67.67, -67.76 85.4, 21.53 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.13, 142.73 APE9-dihe-na 132.91, -126.28 APE8-dihe-in -146.05, 131.58 APE8-rot-out 3.64 APE67-dihe-in -75.87, -9.86 -31.39, -53.34 APE12-dist-in 10.706 APE11-dist-in 11.097 APE10-dist-in 5.491 APE9-dist-in 3.782 None None None XRAY 3.3 0.244 0.31 B 415 396 0 0 0 0 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NDMC 6 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.992 13.635 ABAminus -126.83, -28.62 -112.07, 139.0 -136.27, 9.02 298.66, 85.88 -64.37, 58.3 in-in in 9.095 Saltbr-in 2.606 HRD-in -61.33, -59.76 82.3, 14.91 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.83 APE8-rot-in 289.24 APE67-dihe-in -57.51, 0.5 -55.13, -56.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.244 0.31 C 415 370 27 0 0 5 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3NDMD 7 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.558 12.915 ABAminus -131.86, -23.53 -116.86, 142.93 -139.56, 15.34 308.38, 98.2 -65.61, 50.23 in-in in 8.897 Saltbr-in 3.292 HRD-in -62.78, -65.01 82.89, 25.17 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 144.78 APE9-dihe-na 137.32, -133.95 APE8-dihe-in -135.6, 138.94 APE8-rot-in 312.66 APE67-dihe-in -58.83, -6.42 -51.7, -57.53 APE12-dist-in 10.726 APE11-dist-in 11.123 APE10-dist-in 5.525 APE9-dist-in 3.966 None None None XRAY 3.3 0.244 0.31 D 415 396 0 0 0 0 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNFA 7 401 1354.0 B4V:60501 Type1 Inactive DFGin 6.037 13.819 ABAminus -112.9, -18.08 -125.42, 134.15 -136.13, 27.61 308.44, 98.66 -67.13, -15.25 in-in in 9.248 Saltbr-in 2.85 HRD-in -71.62, -55.08 69.7, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.82, 159.62 APE9-dihe-na 114.62, -153.36 APE8-dihe-in -121.99, 142.9 APE8-rot-out 46.24 APE67-dihe-in -85.9, -24.36 -50.23, -33.75 APE12-dist-in 10.846 APE11-dist-in 11.24 APE10-dist-in 5.38 APE9-dist-in 3.488 None None None XRAY 2.45 0.237 0.247 A 415 395 0 0 0 0 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNFB 6 402 1354.0 B4V:60900 Type1 Inactive DFGin 6.01 13.809 ABAminus -112.8, -19.42 -121.66, 133.79 -135.75, 27.87 308.04, 98.76 -66.99, -15.52 in-in in 9.203 Saltbr-in 2.829 HRD-in -56.58, -57.45 66.78, 9.49 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.62 APE8-rot-out 185.84 APE67-dihe-out -96.25, -5.58 -76.73, 157.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.237 0.247 B 415 357 30 0 0 7 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNFC 6 402 1354.0 B4V:60900 Type1 Inactive DFGin 6.053 13.734 ABAminus -112.34, -18.7 -124.86, 134.18 -135.55, 28.39 308.28, 99.0 -66.12, -17.35 in-in in 9.167 Saltbr-in 2.825 HRD-in -54.29, -57.6 67.49, 9.1 in-in-out SNCiio in-out ActLoopNT-in 3.113 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.13, 155.5 APE9-dihe-na 100.24, 173.54 APE8-dihe-in -65.25, 143.72 APE8-rot-out 166.74 APE67-dihe-in -84.72, -32.31 -63.88, -30.83 APE12-dist-in 10.866 APE11-dist-in 11.263 APE10-dist-in 5.395 APE9-dist-in 3.711 None None None XRAY 2.45 0.237 0.247 C 415 384 9 0 0 0 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNFD 7 402 1354.0 B4V:60900 Type1 Inactive DFGin 5.998 13.798 ABAminus -116.97, -16.71 -124.97, 134.65 -136.46, 28.19 307.91, 98.81 -65.17, -16.17 in-in in 9.272 Saltbr-in 2.853 HRD-in -65.28, -52.76 63.38, 9.16 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.89, 153.13 APE9-dihe-na 122.32, -150.94 APE8-dihe-in -121.83, 134.39 APE8-rot-in 304.55 APE67-dihe-in -67.21, -32.35 -51.49, -41.1 APE12-dist-in 10.448 APE11-dist-in 11.406 APE10-dist-in 5.498 APE9-dist-in 3.771 None None None XRAY 2.45 0.237 0.247 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNGA 7 401 1354.0 B4Y:60900 Type1 Inactive DFGin 5.977 13.509 ABAminus -104.78, -47.26 -102.37, 133.32 -128.78, 19.38 307.6, 97.01 -57.06, -32.21 in-in in 8.889 Saltbr-in 2.786 HRD-in -66.26, -51.49 72.53, -8.5 in-in-out SNCiio in-out ActLoopNT-in 3.065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.53, 147.93 APE9-dihe-na 135.56, -145.58 APE8-dihe-in -132.84, 135.01 APE8-rot-out 33.77 APE67-dihe-in -86.48, -37.64 -34.31, -39.64 APE12-dist-in 11.061 APE11-dist-in 11.37 APE10-dist-in 5.558 APE9-dist-in 3.703 None None None XRAY 2.9 0.231 0.25 A 415 395 0 0 0 0 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNGB 6 402 1354.0 B4Y:60900 Type1 Inactive DFGin 6.115 13.674 ABAminus -116.66, -65.65 -74.59, 116.95 -121.4, 25.51 300.62, 111.42 -66.75, -32.14 in-in in 8.63 Saltbr-in 2.816 HRD-in -60.46, -50.75 69.34, -5.89 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.6 APE8-rot-out 38.45 APE67-dihe-out -117.81, -1.71 -74.02, 169.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.231 0.25 B 415 364 23 0 0 7 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNGC 6 402 1354.0 B4Y:60900 Type1 Inactive DFGin 6.25 13.699 ABAminus -112.13, -65.71 -71.21, 131.58 -134.73, 15.31 296.94, 115.81 -61.29, -33.48 in-in in 8.745 Saltbr-in 2.902 HRD-in -54.07, -49.11 68.03, -4.17 in-in-out SNCiio in-out ActLoopNT-in 3.254 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.49, 151.91 APE9-dihe-na 125.81, -139.62 APE8-dihe-in -129.94, 140.76 APE8-rot-out 193.11 APE67-dihe-in -90.91, -38.38 -54.59, -19.55 APE12-dist-in 12.025 APE11-dist-in 11.331 APE10-dist-in 5.506 APE9-dist-in 3.78 None None None XRAY 2.9 0.231 0.25 C 415 385 9 0 0 0 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNGD 7 402 1354.0 B4Y:60900 Type1 Inactive DFGin 5.966 13.648 ABAminus -112.91, -68.51 -77.11, 128.39 -125.32, 34.85 304.06, 106.91 -57.33, -48.7 in-in in 8.582 Saltbr-in 2.835 HRD-in -67.41, -43.54 61.42, -5.48 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 150.67 APE9-dihe-na 129.52, -151.03 APE8-dihe-in -111.91, 139.64 APE8-rot-in 301.32 APE67-dihe-in -86.26, -34.21 -63.2, -20.63 APE12-dist-in 10.285 APE11-dist-in 11.038 APE10-dist-in 5.199 APE9-dist-in 3.783 None None None XRAY 2.9 0.231 0.25 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNHA 6 401 1354.0 B5G:60900 Type1 Inactive DFGin 6.254 14.084 ABAminus -126.85, -43.1 -92.25, 105.27 -105.51, 23.43 302.78, 98.53 -79.59, -3.09 in-in in 9.245 Saltbr-in 2.798 HRD-in -66.14, -40.5 59.01, 4.04 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.68, 140.18 APE9-dihe-na 145.92, -147.99 APE8-dihe-in -117.87, 133.55 APE8-rot-in 336.48 APE67-dihe-in -88.84, -32.74 -46.05, -33.53 APE12-dist-in 10.997 APE11-dist-in 11.645 APE10-dist-in 5.826 APE9-dist-in 3.569 None None None XRAY 3.1 0.227 0.234 A 415 394 0 0 0 0 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNHB 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 6.144 13.78 ABAminus -129.47, -54.81 -79.68, 115.69 -121.99, 26.51 302.73, 109.7 -73.56, -13.31 in-in in 8.705 Saltbr-in 2.821 HRD-in -59.34, -49.1 69.57, -2.06 in-in-out SNCiio in-out ActLoopNT-in 3.304 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.34 APE8-rot-in 317.54 APE67-dihe-out -81.13, -17.85 -72.96, 161.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.227 0.234 B 415 364 27 0 0 7 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNHC 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 6.194 13.467 ABAminus -129.17, -51.51 -79.99, 119.08 -126.12, 27.06 305.6, 119.19 -74.43, -19.79 in-in in 8.756 Saltbr-in 2.816 HRD-in -53.22, -44.09 64.75, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.334 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.33, 164.22 APE9-dihe-na 88.42, -167.51 APE8-dihe-in -97.64, 151.48 APE8-rot-out 44.44 APE67-dihe-in -84.21, -19.91 -62.02, -38.65 APE12-dist-in 10.409 APE11-dist-in 11.594 APE10-dist-in 5.513 APE9-dist-in 4.157 None None None XRAY 3.1 0.227 0.234 C 415 386 9 0 0 0 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNHD 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 5.961 13.847 ABAminus -129.74, -51.1 -87.04, 108.6 -110.61, 24.81 306.94, 102.01 -68.9, -6.61 in-in in 8.789 Saltbr-in 2.815 HRD-in -59.28, -47.58 67.24, -1.66 in-in-in SNCiii in-in ActLoopNT-in 3.261 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.57, 150.52 APE9-dihe-na 117.79, -157.18 APE8-dihe-in -100.56, 138.22 APE8-rot-in 307.58 APE67-dihe-in -71.46, -24.96 -63.42, -32.46 APE12-dist-in 10.637 APE11-dist-in 11.182 APE10-dist-in 5.325 APE9-dist-in 4.172 None None None XRAY 3.1 0.227 0.234 D 415 397 0 0 0 0 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
6E9WA 9 404 1354.0 J0P:501 Type1 Inactive DFGin 5.94 12.907 ABAminus -138.73, -20.79 -111.43, 114.1 -109.17, 19.11 307.72, 100.2 -59.06, -19.52 in-in in 8.74 Saltbr-in 2.804 HRD-in -69.49, -44.89 71.41, -17.92 in-in-in SNCiii in-in ActLoopNT-in 3.053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 148.51 APE9-dihe-na 125.0, -143.28 APE8-dihe-in -119.0, 136.17 APE8-rot-in 293.48 APE67-dihe-in -80.63, -46.93 -50.48, -33.35 APE12-dist-in 11.461 APE11-dist-in 11.324 APE10-dist-in 5.617 APE9-dist-in 4.16 None None None XRAY 2.96 0.197 0.255 A 443 383 5 0 0 0 [[76, 338]] 1.0 6e9w AGC_ROCK1_HUMAN AGC 4.2e-94 320.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
6E9WB 7 401 1354.0 J0P:501 Type1 Inactive DFGin 6.131 13.232 ABAminus -138.25, -17.0 -112.71, 103.23 -100.64, 12.5 302.93, 104.22 -62.68, -19.69 in-in in 8.572 Saltbr-in 2.859 HRD-in -74.05, -53.13 88.59, -33.91 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -80.59, -50.75 APE9-dihe-na 100.48, -142.0 APE8-dihe-in -66.64, 110.65 APE8-rot-in 303.29 APE67-dihe-in -27.98, -53.24 -75.85, -16.15 APE12-dist-in 9.367 APE11-dist-in 11.627 APE10-dist-out 9.912 APE9-dist-out 10.033 None None None XRAY 2.96 0.197 0.255 B 443 380 9 0 0 0 [[76, 338]] 1.0 6e9w AGC_ROCK1_HUMAN AGC 4.2e-94 320.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S26D 6 399 1354.0 No_ligand No_ligand Inactive DFGin 5.74 13.393 BLAminus -135.63, 169.88 65.28, 102.89 -126.18, 46.78 310.06, 94.0 -59.95, -48.52 in-in in 8.609 Saltbr-in 2.712 HRD-out -94.12, 104.52 -83.22, 26.33 in-in-none SNCiin in-none ActLoopNT-in 3.224 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 D 398 256 101 0 0 23 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
8ZH5A 6 402 1354.0 No_ligand No_ligand Inactive DFGin 6.201 13.812 BLAminus -163.2, 177.92 63.74, 56.57 -85.06, 72.84 297.86, 127.64 -89.2, 164.53 in-in in 8.883 Saltbr-in 3.084 HRD-out -68.24, 147.42 -129.11, 149.32 in-in-none SNCiin in-none ActLoopNT-in 3.111 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.61, -8.47 999.0, -57.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.7 0.211 0.26 A 414 381 16 0 0 5 [[76, 338]] 1.0 8zh5 AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S26A 6 401 1354.0 86K:60502 Type1 Inactive DFGin 6.073 13.254 BLAminus -148.44, 169.09 78.33, 71.17 -104.66, 28.05 312.23, 117.85 -62.26, -27.27 in-in in 8.513 Saltbr-in 2.743 HRD-in -60.15, -37.69 63.03, -7.84 in-in-out SNCiio in-out ActLoopNT-in 3.164 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.5 APE8-rot-out 189.11 APE67-dihe-in -62.34, -32.49 -61.49, -27.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 A 398 387 9 0 0 6 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TV7A 9 402 1354.0 07Q:1 Type1 Inactive DFGin 6.141 13.462 BLAminus -126.35, -171.09 45.97, 69.47 -88.78, 8.65 301.41, 82.65 -54.6, -19.4 in-in in 8.749 Saltbr-in 2.566 HRD-out -65.46, -38.18 49.28, -142.26 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -117.48, 157.83 APE9-dihe-na -63.36, -178.67 APE8-dihe-out 60.06, 84.52 APE8-rot-out 58.98 APE67-dihe-in -61.64, -35.43 -43.45, -41.95 APE12-dist-in 11.239 APE11-dist-in 11.898 APE10-dist-in 6.024 APE9-dist-out 8.376 None None None XRAY 2.75 0.205 0.253 A 410 394 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TV7B 6 402 1354.0 07Q:2 Type1 Inactive DFGin 5.857 13.2 BLAminus -126.47, -172.51 48.84, 75.23 -91.42, 11.14 311.64, 99.6 -51.14, -22.86 in-in in 8.601 Saltbr-in 2.832 HRD-in -67.51, -48.56 77.38, -23.22 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.19, 116.98 APE9-dihe-na -63.15, 117.97 APE8-dihe-out 61.18, 138.65 APE8-rot-out 58.98 APE67-dihe-in -71.45, -48.06 -97.86, 39.1 APE12-dist-out 6.296 APE11-dist-in 10.372 APE10-dist-out 8.735 APE9-dist-out 9.993 None None None XRAY 2.75 0.205 0.253 B 410 397 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TV7C 9 402 1354.0 07Q:3 Type1 Inactive DFGin 5.995 13.057 BLAminus -112.83, -173.21 51.38, 70.56 -91.09, 10.07 312.0, 83.09 -58.15, -16.34 in-in in 8.646 Saltbr-in 2.603 HRD-out -60.51, -40.04 50.0, -144.78 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -114.03, 172.25 APE9-dihe-na -61.19, 179.57 APE8-dihe-out 57.96, 81.04 APE8-rot-in 298.99 APE67-dihe-in -60.89, -34.02 -49.59, -35.58 APE12-dist-in 10.411 APE11-dist-in 11.832 APE10-dist-in 5.904 APE9-dist-out 7.951 None None None XRAY 2.75 0.205 0.253 C 410 394 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TV7D 6 402 1354.0 07Q:4 Type1 Inactive DFGin 6.01 13.388 BLAminus -132.56, -173.08 50.96, 76.18 -95.18, 10.41 310.62, 100.91 -52.21, -21.09 in-in in 8.623 Saltbr-in 2.97 HRD-in -71.89, -52.06 76.5, -19.27 in-in-out SNCiio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -125.31, 112.9 APE9-dihe-na -69.4, 112.01 APE8-dihe-out 62.52, 139.7 APE8-rot-in 314.53 APE67-dihe-in -45.86, -52.51 -76.31, -19.81 APE12-dist-out 5.556 APE11-dist-in 10.055 APE10-dist-out 9.448 APE9-dist-out 9.176 None None None XRAY 2.75 0.205 0.253 D 410 397 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3V8SA 8 402 1354.0 0HD:501 Type1 Inactive DFGin 6.144 13.365 BLAminus -131.47, 179.47 60.6, 71.6 -93.5, 10.81 305.1, 96.77 -59.12, -15.76 in-in in 8.804 Saltbr-in 2.742 HRD-in -66.59, -53.55 76.27, -10.47 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.49, 177.7 APE9-dihe-na 96.83, -154.47 APE8-dihe-in -129.74, 143.67 APE8-rot-out 110.69 APE67-dihe-in -64.74, -31.71 -49.91, -44.47 APE12-dist-in 10.402 APE11-dist-in 11.776 APE10-dist-in 5.941 APE9-dist-in 3.727 None None None XRAY 2.286 0.188 0.236 A 410 395 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3V8SB 6 402 1354.0 0HD:501 Type1 Inactive DFGin 6.313 13.649 BLAminus -129.24, 179.74 58.53, 76.73 -94.51, 12.02 303.63, 98.77 -47.53, -31.19 in-in in 8.826 Saltbr-in 3.279 HRD-in -71.19, -49.28 79.11, -22.55 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -114.6, -175.49 APE9-dihe-na -78.94, -129.14 APE8-dihe-in -42.78, 130.14 APE8-rot-in 309.49 APE67-dihe-in -49.83, -43.8 -72.71, -13.77 APE12-dist-out 6.676 APE11-dist-in 10.194 APE10-dist-in 7.063 APE9-dist-out 9.407 None None None XRAY 2.286 0.188 0.236 B 410 397 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3V8SC 8 402 1354.0 0HD:501 Type1 Inactive DFGin 6.229 13.48 BLAminus -131.94, 178.46 61.35, 70.46 -92.71, 10.99 301.74, 97.6 -57.75, -20.03 in-in in 8.789 Saltbr-in 2.919 HRD-in -68.58, -53.3 74.86, -10.72 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.32, 170.47 APE9-dihe-na 100.83, -158.56 APE8-dihe-in -121.14, 144.0 APE8-rot-out 104.69 APE67-dihe-in -65.81, -32.6 -49.38, -42.89 APE12-dist-in 10.322 APE11-dist-in 11.73 APE10-dist-in 5.877 APE9-dist-in 3.799 None None None XRAY 2.286 0.188 0.236 C 410 395 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3V8SD 6 402 1354.0 0HD:501 Type1 Inactive DFGin 6.274 13.681 BLAminus -134.51, 177.57 58.27, 76.4 -93.55, 11.58 303.68, 94.09 -46.72, -30.67 in-in in 8.887 Saltbr-in 3.229 HRD-in -77.06, -45.91 77.83, -23.23 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -92.44, 115.48 APE9-dihe-na -69.73, -64.71 APE8-dihe-in -105.78, 124.29 APE8-rot-in 283.0 APE67-dihe-in -50.65, -45.32 -72.98, -15.17 APE12-dist-in 7.382 APE11-dist-in 10.194 APE10-dist-out 9.123 APE9-dist-out 9.352 None None None XRAY 2.286 0.188 0.236 D 410 397 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7JOUA 9 402 1354.0 VFS:4000 Type1 Inactive DFGin 5.996 13.339 BLAminus -143.11, 174.9 56.51, 84.53 -111.27, 42.13 313.94, 101.63 -66.46, -29.86 in-in in 8.585 Saltbr-in 2.649 HRD-in -50.19, -37.76 57.05, 15.82 in-in-out SNCiio in-out ActLoopNT-in 3.205 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.97, 107.53 APE9-dihe-na 156.7, 175.62 APE8-dihe-in -79.94, 144.48 APE8-rot-out 53.34 APE67-dihe-in -106.84, -34.67 -68.39, -2.9 APE12-dist-in 11.152 APE11-dist-in 12.095 APE10-dist-in 6.197 APE9-dist-in 3.941 None None None XRAY 3.318 0.218 0.248 A 413 388 6 0 0 0 [[76, 338]] 1.0 7jou AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2ESMB 6 402 1354.0 M77:60416 Type1 Inactive DFGin 6.061 13.637 BLAminus -120.7, -179.63 48.01, 93.78 -115.66, 13.56 300.62, 93.21 -64.59, 23.21 in-in in 8.7 Saltbr-in 2.809 HRD-in -64.68, -48.55 75.56, -17.87 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -120.49, 130.15 APE9-dihe-na -108.34, 137.67 APE8-dihe-out 42.68, 79.42 APE8-rot-out 61.99 APE67-dihe-in -35.68, -40.73 -70.2, -8.79 APE12-dist-in 8.402 APE11-dist-in 12.146 APE10-dist-out 11.118 APE9-dist-out 9.349 None None None XRAY 3.2 0.245 0.269 B 415 397 0 0 0 0 [[76, 338]] 1.0 2esm AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2ETKB 6 402 1354.0 HFS:60416 Type1 Inactive DFGin 6.099 14.036 BLAminus -119.07, 154.83 65.29, 101.07 -117.09, 36.18 302.09, 93.41 -68.48, -4.85 in-in in 9.089 Saltbr-in 3.243 HRD-in -65.95, -45.05 68.6, -11.17 in-in-out SNCiio in-out ActLoopNT-in 3.209 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -71.16, 135.51 APE9-dihe-na -102.49, 125.46 APE8-dihe-out 53.01, 88.66 APE8-rot-out 64.43 APE67-dihe-in -46.44, -46.86 -71.84, 0.84 APE12-dist-in 8.509 APE11-dist-in 12.745 APE10-dist-out 10.626 APE9-dist-out 9.202 None None None XRAY 2.96 0.278 0.298 B 415 397 0 0 0 0 [[76, 338]] 1.0 2etk AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
2ETRB 6 402 1354.0 Y27:60416 Type1 Inactive DFGin 5.864 13.479 BLAminus -117.79, 150.58 66.33, 120.21 -134.86, 36.11 306.16, 88.12 -76.52, 0.93 in-in in 8.686 Saltbr-in 2.752 HRD-in -64.78, -48.06 73.52, -11.25 in-in-out SNCiio in-out ActLoopNT-in 3.134 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -133.18, 138.43 APE9-dihe-na -103.78, 137.39 APE8-dihe-out 35.65, 91.86 APE8-rot-out 53.99 APE67-dihe-in -36.65, -43.6 -71.33, -4.49 APE12-dist-in 8.911 APE11-dist-in 12.333 APE10-dist-out 10.993 APE9-dist-out 9.421 None None None XRAY 2.6 0.252 0.266 B 415 397 0 0 0 0 [[76, 338]] 1.0 2etr AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3D9VB 6 402 1354.0 H52:60416 Type1 Inactive DFGin 6.233 14.285 BLAminus -106.4, 155.82 65.21, 114.96 -130.45, 38.78 300.73, 91.97 -71.81, 5.36 in-in in 9.284 Saltbr-in 3.361 HRD-in -72.68, -45.11 70.15, -5.49 in-in-out SNCiio in-out ActLoopNT-in 3.348 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -129.14, 113.22 APE9-dihe-na -106.7, 121.13 APE8-dihe-out 49.67, 80.41 APE8-rot-out 65.01 APE67-dihe-in -69.09, -34.75 -74.38, 9.95 APE12-dist-in 8.626 APE11-dist-in 11.99 APE10-dist-out 12.647 APE9-dist-out 8.602 None None None XRAY 3.3 0.262 0.28 B 415 397 0 0 0 0 [[76, 338]] 1.0 3d9v AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4YVCB 6 402 1354.0 4KH:60501 Type1 Inactive DFGin 5.987 13.03 BLAminus -134.48, 170.05 59.86, 81.37 -101.66, 32.67 304.4, 103.91 -59.54, -31.24 in-in in 8.077 Saltbr-in 2.876 HRD-in -67.8, -48.64 81.06, -11.79 in-in-out SNCiio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -102.76, 137.3 APE9-dihe-na -116.91, 99.15 APE8-dihe-out 69.44, 93.76 APE8-rot-in 303.49 APE67-dihe-in -38.38, -37.91 -75.8, -10.12 APE12-dist-in 8.33 APE11-dist-in 11.844 APE10-dist-out 10.644 APE9-dist-out 9.52 None None None XRAY 3.2 0.193 0.221 B 415 391 0 0 0 0 [[76, 338]] 1.0 4yvc AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
4YVEB 6 402 1354.0 4KK:60501 Type1 Inactive DFGin 5.949 13.034 BLAminus -142.15, 177.6 55.83, 66.0 -91.48, 48.79 310.94, 106.94 -71.74, -55.62 in-in in 8.402 Saltbr-in 2.706 HRD-in -79.37, -42.41 80.29, -49.62 in-in-out SNCiio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -118.45, 127.42 APE9-dihe-na -99.77, 159.7 APE8-dihe-out 61.11, 72.27 APE8-rot-in 329.33 APE67-dihe-in -42.85, -44.14 -72.95, -1.39 APE12-dist-in 8.194 APE11-dist-in 11.937 APE10-dist-in 7.801 APE9-dist-out 10.537 None None None XRAY 3.4 0.219 0.244 B 415 392 0 0 0 0 [[76, 338]] 1.0 4yve AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5BMLB 6 402 1354.0 4TW:60501 Type1 Inactive DFGin 6.168 12.813 BLAminus -147.33, 171.63 63.14, 85.86 -106.59, 29.54 304.93, 104.29 -62.75, -25.28 in-in in 8.166 Saltbr-in 3.067 HRD-in -63.43, -48.76 84.09, -44.69 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -95.23, 140.75 APE9-dihe-na -114.06, 93.2 APE8-dihe-out 74.29, 102.13 APE8-rot-in 315.97 APE67-dihe-in -37.39, -45.07 -85.5, -0.43 APE12-dist-in 8.479 APE11-dist-in 11.901 APE10-dist-out 10.138 APE9-dist-out 10.233 None None None XRAY 2.95 0.207 0.235 B 415 394 0 0 0 0 [[76, 338]] 1.0 5bml AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5UZJB 6 402 1354.0 8UV:60501 Type1 Inactive DFGin 6.193 13.233 BLAminus -141.66, 165.11 62.71, 74.36 -91.14, 38.13 303.19, 107.23 -56.15, -61.3 in-in in 8.556 Saltbr-in 2.669 HRD-in -70.32, -41.49 73.65, -34.67 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.09, 138.52 APE9-dihe-na -78.02, -115.28 APE8-dihe-in -91.0, 118.08 APE8-rot-out 62.39 APE67-dihe-in -38.15, -42.63 -62.29, -19.27 APE12-dist-in 8.509 APE11-dist-in 11.348 APE10-dist-out 10.742 APE9-dist-out 9.849 None None None XRAY 3.3 0.202 0.241 B 415 385 6 0 0 0 [[76, 338]] 1.0 5uzj AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TWJA 7 402 1354.0 07R:1 Type1.5_Back Inactive DFGin 5.7 13.165 BLAminus -143.98, -170.74 43.72, 70.92 -91.2, 6.87 296.12, 123.32 -47.0, -46.98 in-in in 8.565 Saltbr-in 2.723 HRD-out -68.6, -38.18 61.09, 82.09 in-in-out SNCiio in-out ActLoopNT-in 3.15 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -137.63, -171.58 APE9-dihe-na -153.4, 162.36 APE8-dihe-out 59.85, 72.82 APE8-rot-in 311.01 APE67-dihe-in -44.17, -44.94 -71.0, -20.06 APE12-dist-in 7.743 APE11-dist-in 11.217 APE10-dist-out 8.638 APE9-dist-out 9.812 None None None XRAY 2.9 0.224 0.289 A 410 396 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5HVUB 6 402 1354.0 65R:60501 Type1.5_Front Inactive DFGin 6.027 12.975 BLAminus -150.94, 172.97 62.5, 81.89 -105.96, 31.62 305.32, 102.48 -65.13, -10.17 in-in in 8.313 Saltbr-in 2.938 HRD-in -68.69, -52.17 76.83, -16.13 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.5 APE8-rot-out 85.32 APE67-dihe-in -36.29, -45.18 -89.86, -8.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.239 0.248 B 415 393 4 0 0 4 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5KKSB 6 402 1354.0 6U1:60501 Type1.5_Front Inactive DFGin 6.14 13.336 BLAminus -142.66, 177.11 58.73, 60.85 -80.32, 21.73 304.44, 101.0 -56.11, -39.34 in-in in 8.227 Saltbr-in 2.746 HRD-in -68.72, -42.28 78.49, -44.71 in-in-out SNCiio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -104.48, 133.16 APE9-dihe-na -95.73, 130.38 APE8-dihe-out 63.66, 89.81 APE8-rot-out 67.34 APE67-dihe-in -44.41, -53.62 -78.83, 5.04 APE12-dist-in 8.715 APE11-dist-in 12.174 APE10-dist-out 8.649 APE9-dist-out 10.213 None None None XRAY 3.3 0.215 0.254 B 415 394 0 0 0 0 [[76, 338]] 1.0 5kks AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5KKTB 6 402 1354.0 6U2:60501 Type1.5_Front Inactive DFGin 6.306 13.599 BLAminus -130.02, -177.11 50.1, 80.15 -95.96, 18.23 299.48, 98.02 -62.02, -10.47 in-in in 8.889 Saltbr-in 2.78 HRD-in -68.38, -47.41 71.48, -14.73 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -110.61, 86.79 APE9-dihe-na -63.17, 97.09 APE8-dihe-out 74.12, 110.85 APE8-rot-in 316.95 APE67-dihe-in -53.36, -37.05 -91.57, 10.0 APE12-dist-in 8.432 APE11-dist-in 11.357 APE10-dist-out 10.199 APE9-dist-out 9.422 None None None XRAY 2.8 0.223 0.237 B 415 393 0 0 0 0 [[76, 338]] 1.0 5kkt AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S26C 8 402 1354.0 86K:60501 Type1 Inactive DFGin 5.95 13.37 BLBminus -142.33, 179.72 55.18, 85.73 -101.52, 145.33 303.83, 102.55 -56.13, 999.0 in-in in 8.639 Saltbr-in 2.744 HRD-in -63.89, -36.06 71.41, -31.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.87 APE8-rot-out 190.89 APE67-dihe-in -62.24, -33.76 -58.59, -27.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 C 398 363 18 0 0 18 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TWJC 7 402 1354.0 07R:2 Type1 Inactive DFGin 8.759 16.273 None -145.99, 165.67 60.97, 69.02 -57.54, -10.47 212.34, 59.8 -68.93, 18.62 in-out in 7.794 Saltbr-out 3.822 HRD-in -73.44, -64.4 76.54, -16.94 out-out-out SNCooo out-out ActLoopNT-out 3.649 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oiio APE10-dihe-na -174.55, 155.89 APE9-dihe-na -163.77, 151.18 APE8-dihe-out 67.81, 65.3 APE8-rot-in 318.87 APE67-dihe-in -61.73, -42.12 -68.66, -9.31 APE12-dist-out 6.763 APE11-dist-in 8.218 APE10-dist-in 6.246 APE9-dist-out 9.049 None None None XRAY 2.9 0.224 0.289 C 410 396 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TWJB 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.815 7.295 None -140.02, 177.72 -138.03, 117.9 -134.18, -179.7 267.51, 14.98 -75.11, 143.68 in-in in 8.042 Saltbr-in 3.562 HRD-in -70.23, -44.84 80.45, -14.54 in-out-out SNCioo out-out ActLoopNT-out 20.375 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.17, 145.08 APE9-dihe-na 57.93, -141.29 APE8-dihe-in -142.15, 148.38 APE8-rot-out 101.8 APE67-dihe-in -61.61, -39.57 -51.91, -51.11 APE12-dist-in 11.787 APE11-dist-in 13.034 APE10-dist-out 12.316 APE9-dist-in 4.196 None None None XRAY 2.9 0.224 0.289 B 410 395 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
3TWJD 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.79 6.927 None -126.16, 176.03 -134.68, 123.87 -143.34, -165.47 284.96, 15.3 -95.64, -168.75 in-in in 8.257 Saltbr-in 2.943 HRD-in -49.62, -47.32 79.16, -22.55 in-out-out SNCioo out-out ActLoopNT-out 20.397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na 45.48, 65.51 APE9-dihe-na 78.31, -176.86 APE8-dihe-in -88.74, 143.63 APE8-rot-out 17.15 APE67-dihe-in -61.11, -33.54 -55.29, -47.59 APE12-dist-in 9.993 APE11-dist-in 10.777 APE10-dist-out 10.945 APE9-dist-in 5.297 None None None XRAY 2.9 0.224 0.289 D 410 395 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S25A 7 401 1354.0 86G:504 Type1 Inactive DFGout 12.318 10.54 None -104.78, 156.55 -123.71, 119.26 -167.75, -177.1 52.05, 88.34 -122.16, 999.0 in-in in 8.453 Saltbr-in 2.76 HRD-in -48.48, -35.86 65.44, -17.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.37 APE8-dihe-in -84.85, 138.74 APE8-rot-in 343.84 APE67-dihe-in -53.73, -33.25 -65.56, -53.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.105 None None None XRAY 2.337 0.24 0.271 A 396 373 22 0 0 17 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S25B 8 402 1354.0 86G:501 Type1 Inactive DFGout 12.161 10.144 None -102.96, 170.2 -133.51, 102.53 -164.51, 160.19 55.37, 93.46 -104.18, 142.28 in-in in 8.647 Saltbr-in 2.71 HRD-in -64.3, -54.36 69.65, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -102.96, -6.09 APE9-dihe-na 73.94, -123.45 APE8-dihe-in -79.15, 120.74 APE8-rot-in 312.82 APE67-dihe-in -46.47, -33.29 -85.89, -15.42 APE12-dist-in 11.32 APE11-dist-in 11.306 APE10-dist-out 9.412 APE9-dist-out 8.405 None None None XRAY 2.337 0.24 0.271 B 396 379 12 0 0 12 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S25C 13 402 1354.0 86G:501 Type1 Inactive DFGout 12.693 10.544 None -104.89, 170.47 -133.65, 98.69 -152.01, 158.42 54.9, 83.0 -75.12, 999.0 in-in in 8.505 Saltbr-in 2.799 HRD-in -63.41, -47.95 72.04, -26.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 89.67 APE8-rot-out 72.08 APE67-dihe-in -54.43, -34.25 -48.72, -39.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.337 0.24 0.271 C 396 361 18 0 0 18 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S25D 9 401 1354.0 No_ligand No_ligand Inactive None 999.0 999.0 None -105.32, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.472 Saltbr-in 2.733 HRD-in -82.09, -47.81 61.94, 11.48 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.337 0.24 0.271 D 396 257 113 0 0 29 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
7S26B 6 402 1354.0 86K:60502 Type1 None DFGin 5.894 13.466 BLAminus -142.81, 170.64 62.27, 84.33 -99.22, -25.13 305.67, 98.88 -149.72, 999.0 in-in in 8.694 Saltbr-in 2.732 HRD-in -65.9, -38.81 79.64, -62.78 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.9, -32.72 999.0, -32.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 B 398 372 19 0 0 19 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
5WNEB 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus -143.39, 177.51 52.52, 73.92 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1

AGC_ROCK1 (Rho-associated protein kinase 1)

Total number of chains: 78
Active chains: 22
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 48 61.5% AF-Q13464-K1A
DFGin ABAminus 22 28.2% 5WNFA
DFGout None 3 3.8% 7S25B
DFGinter None 2 2.6% 3TWJB
DFGin BLBminus 1 1.3% 7S26C
DFGin None 1 1.3% 3TWJC
None None 1 1.3% 7S25D
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.88 13.604 BLAminus -137.29, -177.31 60.22, 109.9 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.076 Saltbr-in 2.708 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.281 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.324 APE11-dist-in 11.278 APE10-dist-in 5.647 APE9-dist-in 4.131 None None None XRAY 3.705 0.238 0.269 A 406 393 0 0 0 0 [[76, 338]] 1.0 2v55 Homo sapiens AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.884 13.608 BLAminus -137.56, -177.44 62.15, 108.48 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.247 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.28 APE11-dist-in 11.269 APE10-dist-in 5.623 APE9-dist-in 4.097 None None None XRAY 3.705 0.238 0.269 C 406 396 0 0 0 0 [[76, 338]] 1.0 2v55 Homo sapiens AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN AF-Q13464-K1A Q13464 68 346 1354.0 No_ligand No_ligand Active DFGin 6.006 13.066 BLAminus -137.66, -178.75 47.45, 69.34 -81.8, 16.56 305.27, 105.28 -65.56, -12.08 in-in in 8.552 Saltbr-in 2.624 HRD-in -74.85, -46.42 64.04, 4.32 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.58, 160.73 APE9-dihe-na 98.63, 175.06 APE8-dihe-in -68.34, 133.89 APE8-rot-in 288.19 APE67-dihe-in -75.11, -22.05 -52.44, -39.16 APE12-dist-in 10.159 APE11-dist-in 11.26 APE10-dist-in 5.393 APE9-dist-in 3.726 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K1 Homo sapiens AGC_ROCK1_HUMAN AGC 9.2e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN AF-Q13464-K3A Q13464 68 346 1354.0 No_ligand No_ligand Active DFGin 5.851 13.271 BLAminus -137.07, 179.96 52.49, 70.51 -80.48, 13.64 307.69, 107.27 -65.8, -8.31 in-in in 8.833 Saltbr-in 2.683 HRD-in -84.07, -47.73 66.69, 2.67 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.35, 143.29 APE9-dihe-na 121.73, 178.17 APE8-dihe-in -80.88, 131.47 APE8-rot-in 300.07 APE67-dihe-in -72.64, -15.78 -48.59, -46.75 APE12-dist-in 10.802 APE11-dist-in 11.642 APE10-dist-in 5.871 APE9-dist-in 3.256 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K3 Homo sapiens AGC_ROCK1_HUMAN AGC 9.2e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4W7PA Q13464 6 405 1354.0 3J7:501 Type1 Active DFGin 6.259 12.978 BLAminus -131.32, -179.69 55.02, 77.47 -91.49, 17.42 302.12, 101.71 -69.96, -11.88 in-in in 8.182 Saltbr-in 2.566 HRD-in -62.73, -47.54 67.38, -1.52 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.79, 138.22 APE9-dihe-na 110.79, -174.17 APE8-dihe-in -93.29, 129.06 APE8-rot-in 302.8 APE67-dihe-in -74.33, -31.52 -36.7, -38.86 APE12-dist-in 10.731 APE11-dist-in 11.462 APE10-dist-in 5.952 APE9-dist-in 3.674 None None None XRAY 2.8 0.208 0.246 A 411 388 6 0 0 0 [[76, 338]] 1.0 4w7p Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4W7PB Q13464 6 401 1354.0 3J7:501 Type1 Active DFGin 6.154 13.435 BLAminus -133.96, 174.8 56.5, 83.88 -98.36, 33.02 302.17, 98.2 -70.04, -15.43 in-in in 8.214 Saltbr-in 2.726 HRD-in -62.94, -46.77 66.68, -0.73 in-in-in SNCiii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.83, 139.14 APE9-dihe-na 109.13, -172.67 APE8-dihe-in -92.68, 127.41 APE8-rot-in 302.74 APE67-dihe-in -74.45, -31.78 -35.08, -39.48 APE12-dist-in 10.707 APE11-dist-in 11.408 APE10-dist-in 5.883 APE9-dist-in 3.703 None None None XRAY 2.8 0.208 0.246 B 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4W7PC Q13464 6 401 1354.0 3J7:501 Type1 Active DFGin 6.282 13.256 BLAminus -124.31, 179.51 53.21, 87.62 -105.48, 23.02 305.5, 95.5 -67.24, -3.72 in-in in 8.257 Saltbr-in 2.797 HRD-in -62.84, -46.85 67.56, -2.48 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.95, 139.35 APE9-dihe-na 109.16, -174.28 APE8-dihe-in -91.11, 127.59 APE8-rot-in 304.22 APE67-dihe-in -73.68, -32.3 -37.14, -39.74 APE12-dist-in 10.725 APE11-dist-in 11.541 APE10-dist-in 6.024 APE9-dist-in 3.675 None None None XRAY 2.8 0.208 0.246 C 411 383 7 0 0 0 [[76, 338]] 1.0 4w7p Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4W7PD Q13464 6 403 1354.0 3J7:501 Type1 Active DFGin 6.352 13.321 BLAminus -140.19, -177.5 56.39, 77.39 -95.5, 16.8 300.98, 99.72 -61.76, -14.51 in-in in 8.291 Saltbr-in 2.836 HRD-in -63.87, -49.18 67.62, 4.17 in-in-in SNCiii in-in ActLoopNT-in 3.098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.12, 138.83 APE9-dihe-na 110.39, -175.06 APE8-dihe-in -91.75, 128.12 APE8-rot-in 303.98 APE67-dihe-in -75.08, -31.43 -35.22, -39.46 APE12-dist-in 10.68 APE11-dist-in 11.483 APE10-dist-in 5.932 APE9-dist-in 3.702 None None None XRAY 2.8 0.208 0.246 D 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2ESMA Q13464 6 405 1354.0 M77:60416 Type1 Active DFGin 6.105 13.688 BLAminus -120.74, 175.27 52.57, 92.93 -113.78, 23.07 302.86, 94.18 -55.5, -15.7 in-in in 8.584 Saltbr-in 2.762 HRD-in -64.55, -47.39 72.73, -12.37 in-in-in SNCiii in-in ActLoopNT-in 3.313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 156.73 APE9-dihe-na 129.25, -151.41 APE8-dihe-in -127.71, 135.99 APE8-rot-in 310.98 APE67-dihe-in -65.34, -28.12 -39.62, -57.01 APE12-dist-in 11.724 APE11-dist-in 11.453 APE10-dist-in 5.777 APE9-dist-in 3.535 None None None XRAY 3.2 0.245 0.269 A 415 400 0 0 0 0 [[76, 338]] 1.0 2esm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2ETKA Q13464 6 405 1354.0 HFS:60416 Type1 Active DFGin 6.059 14.097 BLAminus -116.57, 151.42 65.52, 106.25 -118.99, 38.28 303.23, 95.7 -62.53, -30.1 in-in in 9.024 Saltbr-in 3.087 HRD-in -67.16, -45.15 69.82, -9.8 in-in-in SNCiii in-in ActLoopNT-in 3.224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.46, 135.93 APE9-dihe-na 138.1, -153.58 APE8-dihe-in -121.49, 133.91 APE8-rot-in 318.16 APE67-dihe-in -78.08, -32.49 -44.0, -39.32 APE12-dist-in 11.84 APE11-dist-in 11.546 APE10-dist-in 5.856 APE9-dist-in 3.737 None None None XRAY 2.96 0.278 0.298 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etk Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2ETRA Q13464 6 405 1354.0 Y27:60416 Type1 Active DFGin 6.023 14.033 BLAminus -115.35, 151.29 66.22, 120.62 -135.54, 23.8 302.55, 92.69 -59.35, -26.34 in-in in 8.786 Saltbr-in 2.733 HRD-in -66.03, -45.85 73.19, -11.33 in-in-in SNCiii in-in ActLoopNT-in 3.095 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 135.12 APE9-dihe-na 138.18, -155.48 APE8-dihe-in -122.76, 133.42 APE8-rot-in 310.03 APE67-dihe-in -71.74, -29.22 -38.34, -50.83 APE12-dist-in 11.748 APE11-dist-in 11.548 APE10-dist-in 5.877 APE9-dist-in 3.701 None None None XRAY 2.6 0.252 0.266 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etr Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3D9VA Q13464 6 405 1354.0 H52:60416 Type1 Active DFGin 6.202 14.259 BLAminus -97.17, 154.71 64.91, 125.89 -137.95, 39.08 298.06, 99.68 -71.65, -6.65 in-in in 9.177 Saltbr-in 3.154 HRD-in -71.72, -45.61 70.74, -5.17 in-in-in SNCiii in-in ActLoopNT-in 3.202 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.18, 131.07 APE9-dihe-na 140.68, -156.12 APE8-dihe-in -114.86, 135.68 APE8-rot-in 311.45 APE67-dihe-in -80.47, -37.33 -48.71, -38.59 APE12-dist-in 11.746 APE11-dist-in 11.776 APE10-dist-in 6.137 APE9-dist-in 3.756 None None None XRAY 3.3 0.262 0.28 A 415 400 0 0 0 0 [[76, 338]] 1.0 3d9v Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4YVCA Q13464 6 405 1354.0 4KH:60501 Type1 Active DFGin 5.87 13.114 BLAminus -131.73, 179.43 49.79, 78.91 -95.58, 35.98 309.76, 96.36 -52.74, -39.15 in-in in 8.425 Saltbr-in 3.027 HRD-in -62.91, -47.72 78.09, -4.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.16, 137.86 APE9-dihe-na 126.1, -158.78 APE8-dihe-in -106.17, 145.81 APE8-rot-in 290.0 APE67-dihe-in -72.07, -14.66 -55.89, -48.56 APE12-dist-in 11.644 APE11-dist-in 11.414 APE10-dist-in 5.915 APE9-dist-in 3.809 None None None XRAY 3.2 0.193 0.221 A 415 388 5 0 0 0 [[76, 338]] 1.0 4yvc Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4YVEA Q13464 6 405 1354.0 4KK:60501 Type1 Active DFGin 5.621 12.807 BLAminus -135.63, 174.2 57.57, 62.47 -84.06, 54.44 321.53, 81.4 -64.54, -38.78 in-in in 8.392 Saltbr-in 2.839 HRD-in -66.81, -33.75 61.05, -11.49 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.37, 139.44 APE9-dihe-na 133.32, -156.65 APE8-dihe-in -109.47, 141.28 APE8-rot-in 300.76 APE67-dihe-in -87.71, -40.47 -52.3, -33.35 APE12-dist-in 11.916 APE11-dist-in 11.54 APE10-dist-in 6.006 APE9-dist-in 3.84 None None None XRAY 3.4 0.219 0.244 A 415 390 4 0 0 0 [[76, 338]] 1.0 4yve Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5BMLA Q13464 6 405 1354.0 4TW:60501 Type1 Active DFGin 6.166 13.115 BLAminus -136.45, -178.03 52.19, 80.38 -99.05, 18.0 302.5, 105.79 -59.89, -6.36 in-in in 8.173 Saltbr-in 2.761 HRD-in -66.74, -49.49 70.73, -5.79 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.01, 144.84 APE9-dihe-na 123.64, -151.58 APE8-dihe-in -116.7, 138.56 APE8-rot-in 292.02 APE67-dihe-in -71.41, -43.61 -45.01, -45.51 APE12-dist-in 12.171 APE11-dist-in 11.52 APE10-dist-in 6.047 APE9-dist-in 3.748 None None None XRAY 2.95 0.207 0.235 A 415 393 2 0 0 0 [[76, 338]] 1.0 5bml Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5KKSA Q13464 6 405 1354.0 6U1:60501 Type1 Active DFGin 6.186 13.352 BLAminus -142.64, 177.27 59.6, 62.04 -81.65, 21.26 304.3, 101.28 -54.79, -41.15 in-in in 8.259 Saltbr-in 2.754 HRD-in -54.42, -38.35 63.96, -11.55 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.2, 147.03 APE9-dihe-na 120.6, -151.04 APE8-dihe-in -115.4, 140.07 APE8-rot-in 299.71 APE67-dihe-in -59.58, -43.85 -44.15, -59.93 APE12-dist-in 11.887 APE11-dist-in 11.441 APE10-dist-in 5.829 APE9-dist-in 3.748 None None None XRAY 3.3 0.215 0.254 A 415 395 0 0 0 0 [[76, 338]] 1.0 5kks Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5KKTA Q13464 6 405 1354.0 6U2:60501 Type1 Active DFGin 6.335 13.585 BLAminus -128.59, -176.48 50.52, 79.42 -95.97, 17.69 299.29, 99.89 -62.82, -14.55 in-in in 8.893 Saltbr-in 2.772 HRD-in -67.63, -48.61 71.19, -4.25 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, 142.19 APE9-dihe-na 128.21, -142.04 APE8-dihe-in -128.93, 139.4 APE8-rot-in 303.92 APE67-dihe-in -73.59, -33.97 -48.22, -44.35 APE12-dist-in 11.474 APE11-dist-in 11.675 APE10-dist-in 6.173 APE9-dist-in 3.606 None None None XRAY 2.8 0.223 0.237 A 415 389 4 0 0 0 [[76, 338]] 1.0 5kkt Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5UZJA Q13464 6 405 1354.0 8UV:60501 Type1 Active DFGin 6.17 13.101 BLAminus -139.82, 174.8 51.53, 74.94 -94.18, 44.21 303.79, 97.11 -58.95, -59.6 in-in in 8.64 Saltbr-in 2.794 HRD-in -71.22, -41.37 70.75, -24.52 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.33, 135.82 APE9-dihe-na 134.09, -159.86 APE8-dihe-in -104.52, 140.59 APE8-rot-in 298.4 APE67-dihe-in -92.6, -25.3 -52.4, -27.33 APE12-dist-in 11.906 APE11-dist-in 11.503 APE10-dist-in 5.992 APE9-dist-in 4.031 None None None XRAY 3.3 0.202 0.241 A 415 387 8 0 0 0 [[76, 338]] 1.0 5uzj Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5HVUA Q13464 6 405 1354.0 65R:60501 Type1.5_Front Active DFGin 6.064 13.008 BLAminus -144.77, -177.33 55.22, 80.15 -106.17, 33.13 305.29, 103.88 -64.0, -11.53 in-in in 8.403 Saltbr-in 2.919 HRD-in -68.11, -52.8 76.77, -16.02 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 135.58 APE9-dihe-na 137.6, -151.11 APE8-dihe-in -124.0, 136.06 APE8-rot-in 298.85 APE67-dihe-in -72.28, -36.35 -46.39, -41.26 APE12-dist-in 12.022 APE11-dist-in 11.468 APE10-dist-in 5.929 APE9-dist-in 3.886 None None None XRAY 2.8 0.239 0.248 A 415 394 0 0 0 0 [[76, 338]] 1.0 5hvu Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNEA Q13464 14 400 1354.0 B4J:60501 Type1.5_Front Active DFGin 6.225 13.567 BLAminus -135.0, 175.35 53.04, 84.77 -102.97, 28.35 302.63, 101.99 -70.63, -10.88 in-in in 8.951 Saltbr-in 2.812 HRD-in -65.73, -50.65 71.21, -5.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 137.37 APE9-dihe-na 126.73, -152.59 APE8-dihe-in -112.81, 138.1 APE8-rot-in 304.24 APE67-dihe-in -78.8, -30.66 -52.66, -36.48 APE12-dist-in 10.985 APE11-dist-in 11.543 APE10-dist-in 5.882 APE9-dist-in 3.725 None None None XRAY 2.6 0.229 0.246 A 415 384 0 0 0 0 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNEC Q13464 6 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.226 13.312 BLAminus -141.6, 173.01 60.67, 84.57 -108.59, 26.04 304.33, 107.59 -71.96, -9.2 in-in in 8.556 Saltbr-in 2.815 HRD-in -53.88, -50.49 68.34, -4.44 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 131.39 APE9-dihe-na 141.47, -150.22 APE8-dihe-in -114.01, 135.26 APE8-rot-in 304.1 APE67-dihe-in -79.17, -28.35 -50.74, -38.29 APE12-dist-in 10.779 APE11-dist-in 11.589 APE10-dist-in 5.735 APE9-dist-in 3.822 None None None XRAY 2.6 0.229 0.246 C 415 382 9 0 0 0 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNED Q13464 7 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.109 13.38 BLAminus -136.38, 179.68 48.06, 76.76 -93.24, 35.49 302.92, 95.86 -65.45, -20.45 in-in in 8.487 Saltbr-in 2.785 HRD-in -58.19, -50.71 67.27, -4.18 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.61, 140.56 APE9-dihe-na 127.23, -150.56 APE8-dihe-in -113.66, 136.6 APE8-rot-in 304.03 APE67-dihe-in -77.29, -31.2 -52.52, -36.89 APE12-dist-in 10.389 APE11-dist-in 11.435 APE10-dist-in 5.778 APE9-dist-in 3.834 None None None XRAY 2.6 0.229 0.246 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NDMA Q13464 6 402 1354.0 No_ligand No_ligand Inactive DFGin 5.598 13.058 ABAminus -120.89, -34.04 -109.2, 148.34 -142.38, 4.69 304.49, 84.24 -63.88, 57.85 in-out in 9.076 Saltbr-out 3.763 HRD-in -57.38, -56.5 79.4, 26.69 out-in-in SNCoii in-in ActLoopNT-in 3.157 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.05, 156.15 APE9-dihe-na 131.42, -138.04 APE8-dihe-in -125.51, 139.35 APE8-rot-in 275.81 APE67-dihe-in -57.52, -0.48 -48.9, -63.05 APE12-dist-in 10.485 APE11-dist-in 11.171 APE10-dist-in 5.509 APE9-dist-in 4.003 None None None XRAY 3.3 0.244 0.31 A 415 382 11 0 0 0 [[76, 338]] 1.0 3ndm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NCZA Q13464 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.335 13.775 ABAminus -116.14, -12.55 -138.55, 134.31 -126.47, 14.42 296.82, 87.82 -51.46, -39.63 in-in in 9.306 Saltbr-in 3.537 HRD-in -78.05, -50.28 73.4, -14.49 in-in-in SNCiii in-in ActLoopNT-in 3.161 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.89, -176.36 APE9-dihe-na 133.28, -167.86 APE8-dihe-in -125.48, 134.73 APE8-rot-in 280.08 APE67-dihe-in -84.68, -47.89 -24.91, -55.61 APE12-dist-in 12.595 APE11-dist-in 10.072 APE10-dist-in 5.448 APE9-dist-in 3.551 None None None XRAY 3.0 0.259 0.328 A 415 397 0 0 0 0 [[76, 338]] 1.0 3ncz Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NCZB Q13464 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.168 13.439 ABAminus -114.85, -16.66 -131.56, 138.9 -136.04, 17.21 298.24, 65.97 -58.26, -38.43 in-in in 9.313 Saltbr-in 2.492 HRD-in -79.75, -44.81 74.12, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -112.01 APE9-dihe-na -175.97, -67.78 APE8-dihe-in -149.88, 165.72 APE8-rot-out 209.54 APE67-dihe-in -50.79, -11.63 -86.98, -72.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.143 APE9-dist-in 4.977 None None None XRAY 3.0 0.259 0.328 B 415 377 15 0 0 2 [[76, 338]] 1.0 3ncz Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NCZC Q13464 6 404 1354.0 3NC:60900 Type1 Inactive DFGin 5.957 13.35 ABAminus -116.08, -7.73 -136.42, 136.67 -131.83, 24.74 306.96, 86.44 -58.54, -34.95 in-in in 9.223 Saltbr-in 3.491 HRD-in -83.49, -46.62 73.83, -20.27 in-in-in SNCiii in-in ActLoopNT-in 3.156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.05, 125.19 APE9-dihe-na 160.07, -158.87 APE8-dihe-in -144.7, 128.84 APE8-rot-in 311.05 APE67-dihe-in -25.99, -52.32 -21.36, -99.97 APE12-dist-in 10.188 APE11-dist-in 11.672 APE10-dist-in 5.728 APE9-dist-in 3.595 None None None XRAY 3.0 0.259 0.328 C 415 387 6 0 0 1 [[76, 338]] 1.0 3ncz Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NCZD Q13464 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.007 13.398 ABAminus -130.28, 7.59 -144.4, 127.27 -129.17, 19.34 304.27, 91.75 -57.04, -39.11 in-in in 9.214 Saltbr-in 3.563 HRD-in -74.16, -50.68 74.64, -10.85 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.26, 158.97 APE9-dihe-na 125.95, -146.31 APE8-dihe-in -122.54, 128.42 APE8-rot-in 314.26 APE67-dihe-in -57.68, -28.69 -36.8, -72.93 APE12-dist-in 12.398 APE11-dist-in 11.269 APE10-dist-in 6.343 APE9-dist-in 4.414 None None None XRAY 3.0 0.259 0.328 D 415 397 0 0 0 0 [[76, 338]] 1.0 3ncz Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NDMB Q13464 7 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.577 13.291 ABAminus -135.55, -20.22 -111.5, 137.71 -126.94, 16.16 300.9, 101.92 -51.55, 28.77 in-in in 9.054 Saltbr-in 3.139 HRD-in -67.67, -67.76 85.4, 21.53 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.13, 142.73 APE9-dihe-na 132.91, -126.28 APE8-dihe-in -146.05, 131.58 APE8-rot-out 3.64 APE67-dihe-in -75.87, -9.86 -31.39, -53.34 APE12-dist-in 10.706 APE11-dist-in 11.097 APE10-dist-in 5.491 APE9-dist-in 3.782 None None None XRAY 3.3 0.244 0.31 B 415 396 0 0 0 0 [[76, 338]] 1.0 3ndm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NDMC Q13464 6 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.992 13.635 ABAminus -126.83, -28.62 -112.07, 139.0 -136.27, 9.02 298.66, 85.88 -64.37, 58.3 in-in in 9.095 Saltbr-in 2.606 HRD-in -61.33, -59.76 82.3, 14.91 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.83 APE8-rot-in 289.24 APE67-dihe-in -57.51, 0.5 -55.13, -56.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.244 0.31 C 415 370 27 0 0 5 [[76, 338]] 1.0 3ndm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3NDMD Q13464 7 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.558 12.915 ABAminus -131.86, -23.53 -116.86, 142.93 -139.56, 15.34 308.38, 98.2 -65.61, 50.23 in-in in 8.897 Saltbr-in 3.292 HRD-in -62.78, -65.01 82.89, 25.17 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 144.78 APE9-dihe-na 137.32, -133.95 APE8-dihe-in -135.6, 138.94 APE8-rot-in 312.66 APE67-dihe-in -58.83, -6.42 -51.7, -57.53 APE12-dist-in 10.726 APE11-dist-in 11.123 APE10-dist-in 5.525 APE9-dist-in 3.966 None None None XRAY 3.3 0.244 0.31 D 415 396 0 0 0 0 [[76, 338]] 1.0 3ndm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNFA Q13464 7 401 1354.0 B4V:60501 Type1 Inactive DFGin 6.037 13.819 ABAminus -112.9, -18.08 -125.42, 134.15 -136.13, 27.61 308.44, 98.66 -67.13, -15.25 in-in in 9.248 Saltbr-in 2.85 HRD-in -71.62, -55.08 69.7, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.82, 159.62 APE9-dihe-na 114.62, -153.36 APE8-dihe-in -121.99, 142.9 APE8-rot-out 46.24 APE67-dihe-in -85.9, -24.36 -50.23, -33.75 APE12-dist-in 10.846 APE11-dist-in 11.24 APE10-dist-in 5.38 APE9-dist-in 3.488 None None None XRAY 2.45 0.237 0.247 A 415 395 0 0 0 0 [[76, 338]] 1.0 5wnf Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNFB Q13464 6 402 1354.0 B4V:60900 Type1 Inactive DFGin 6.01 13.809 ABAminus -112.8, -19.42 -121.66, 133.79 -135.75, 27.87 308.04, 98.76 -66.99, -15.52 in-in in 9.203 Saltbr-in 2.829 HRD-in -56.58, -57.45 66.78, 9.49 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.62 APE8-rot-out 185.84 APE67-dihe-out -96.25, -5.58 -76.73, 157.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.237 0.247 B 415 357 30 0 0 7 [[76, 338]] 1.0 5wnf Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNFC Q13464 6 402 1354.0 B4V:60900 Type1 Inactive DFGin 6.053 13.734 ABAminus -112.34, -18.7 -124.86, 134.18 -135.55, 28.39 308.28, 99.0 -66.12, -17.35 in-in in 9.167 Saltbr-in 2.825 HRD-in -54.29, -57.6 67.49, 9.1 in-in-out SNCiio in-out ActLoopNT-in 3.113 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.13, 155.5 APE9-dihe-na 100.24, 173.54 APE8-dihe-in -65.25, 143.72 APE8-rot-out 166.74 APE67-dihe-in -84.72, -32.31 -63.88, -30.83 APE12-dist-in 10.866 APE11-dist-in 11.263 APE10-dist-in 5.395 APE9-dist-in 3.711 None None None XRAY 2.45 0.237 0.247 C 415 384 9 0 0 0 [[76, 338]] 1.0 5wnf Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNFD Q13464 7 402 1354.0 B4V:60900 Type1 Inactive DFGin 5.998 13.798 ABAminus -116.97, -16.71 -124.97, 134.65 -136.46, 28.19 307.91, 98.81 -65.17, -16.17 in-in in 9.272 Saltbr-in 2.853 HRD-in -65.28, -52.76 63.38, 9.16 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.89, 153.13 APE9-dihe-na 122.32, -150.94 APE8-dihe-in -121.83, 134.39 APE8-rot-in 304.55 APE67-dihe-in -67.21, -32.35 -51.49, -41.1 APE12-dist-in 10.448 APE11-dist-in 11.406 APE10-dist-in 5.498 APE9-dist-in 3.771 None None None XRAY 2.45 0.237 0.247 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wnf Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNGA Q13464 7 401 1354.0 B4Y:60900 Type1 Inactive DFGin 5.977 13.509 ABAminus -104.78, -47.26 -102.37, 133.32 -128.78, 19.38 307.6, 97.01 -57.06, -32.21 in-in in 8.889 Saltbr-in 2.786 HRD-in -66.26, -51.49 72.53, -8.5 in-in-out SNCiio in-out ActLoopNT-in 3.065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.53, 147.93 APE9-dihe-na 135.56, -145.58 APE8-dihe-in -132.84, 135.01 APE8-rot-out 33.77 APE67-dihe-in -86.48, -37.64 -34.31, -39.64 APE12-dist-in 11.061 APE11-dist-in 11.37 APE10-dist-in 5.558 APE9-dist-in 3.703 None None None XRAY 2.9 0.231 0.25 A 415 395 0 0 0 0 [[76, 338]] 1.0 5wng Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNGB Q13464 6 402 1354.0 B4Y:60900 Type1 Inactive DFGin 6.115 13.674 ABAminus -116.66, -65.65 -74.59, 116.95 -121.4, 25.51 300.62, 111.42 -66.75, -32.14 in-in in 8.63 Saltbr-in 2.816 HRD-in -60.46, -50.75 69.34, -5.89 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.6 APE8-rot-out 38.45 APE67-dihe-out -117.81, -1.71 -74.02, 169.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.231 0.25 B 415 364 23 0 0 7 [[76, 338]] 1.0 5wng Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNGC Q13464 6 402 1354.0 B4Y:60900 Type1 Inactive DFGin 6.25 13.699 ABAminus -112.13, -65.71 -71.21, 131.58 -134.73, 15.31 296.94, 115.81 -61.29, -33.48 in-in in 8.745 Saltbr-in 2.902 HRD-in -54.07, -49.11 68.03, -4.17 in-in-out SNCiio in-out ActLoopNT-in 3.254 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.49, 151.91 APE9-dihe-na 125.81, -139.62 APE8-dihe-in -129.94, 140.76 APE8-rot-out 193.11 APE67-dihe-in -90.91, -38.38 -54.59, -19.55 APE12-dist-in 12.025 APE11-dist-in 11.331 APE10-dist-in 5.506 APE9-dist-in 3.78 None None None XRAY 2.9 0.231 0.25 C 415 385 9 0 0 0 [[76, 338]] 1.0 5wng Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNGD Q13464 7 402 1354.0 B4Y:60900 Type1 Inactive DFGin 5.966 13.648 ABAminus -112.91, -68.51 -77.11, 128.39 -125.32, 34.85 304.06, 106.91 -57.33, -48.7 in-in in 8.582 Saltbr-in 2.835 HRD-in -67.41, -43.54 61.42, -5.48 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 150.67 APE9-dihe-na 129.52, -151.03 APE8-dihe-in -111.91, 139.64 APE8-rot-in 301.32 APE67-dihe-in -86.26, -34.21 -63.2, -20.63 APE12-dist-in 10.285 APE11-dist-in 11.038 APE10-dist-in 5.199 APE9-dist-in 3.783 None None None XRAY 2.9 0.231 0.25 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wng Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNHA Q13464 6 401 1354.0 B5G:60900 Type1 Inactive DFGin 6.254 14.084 ABAminus -126.85, -43.1 -92.25, 105.27 -105.51, 23.43 302.78, 98.53 -79.59, -3.09 in-in in 9.245 Saltbr-in 2.798 HRD-in -66.14, -40.5 59.01, 4.04 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.68, 140.18 APE9-dihe-na 145.92, -147.99 APE8-dihe-in -117.87, 133.55 APE8-rot-in 336.48 APE67-dihe-in -88.84, -32.74 -46.05, -33.53 APE12-dist-in 10.997 APE11-dist-in 11.645 APE10-dist-in 5.826 APE9-dist-in 3.569 None None None XRAY 3.1 0.227 0.234 A 415 394 0 0 0 0 [[76, 338]] 1.0 5wnh Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNHB Q13464 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 6.144 13.78 ABAminus -129.47, -54.81 -79.68, 115.69 -121.99, 26.51 302.73, 109.7 -73.56, -13.31 in-in in 8.705 Saltbr-in 2.821 HRD-in -59.34, -49.1 69.57, -2.06 in-in-out SNCiio in-out ActLoopNT-in 3.304 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.34 APE8-rot-in 317.54 APE67-dihe-out -81.13, -17.85 -72.96, 161.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.227 0.234 B 415 364 27 0 0 7 [[76, 338]] 1.0 5wnh Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNHC Q13464 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 6.194 13.467 ABAminus -129.17, -51.51 -79.99, 119.08 -126.12, 27.06 305.6, 119.19 -74.43, -19.79 in-in in 8.756 Saltbr-in 2.816 HRD-in -53.22, -44.09 64.75, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.334 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.33, 164.22 APE9-dihe-na 88.42, -167.51 APE8-dihe-in -97.64, 151.48 APE8-rot-out 44.44 APE67-dihe-in -84.21, -19.91 -62.02, -38.65 APE12-dist-in 10.409 APE11-dist-in 11.594 APE10-dist-in 5.513 APE9-dist-in 4.157 None None None XRAY 3.1 0.227 0.234 C 415 386 9 0 0 0 [[76, 338]] 1.0 5wnh Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNHD Q13464 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 5.961 13.847 ABAminus -129.74, -51.1 -87.04, 108.6 -110.61, 24.81 306.94, 102.01 -68.9, -6.61 in-in in 8.789 Saltbr-in 2.815 HRD-in -59.28, -47.58 67.24, -1.66 in-in-in SNCiii in-in ActLoopNT-in 3.261 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.57, 150.52 APE9-dihe-na 117.79, -157.18 APE8-dihe-in -100.56, 138.22 APE8-rot-in 307.58 APE67-dihe-in -71.46, -24.96 -63.42, -32.46 APE12-dist-in 10.637 APE11-dist-in 11.182 APE10-dist-in 5.325 APE9-dist-in 4.172 None None None XRAY 3.1 0.227 0.234 D 415 397 0 0 0 0 [[76, 338]] 1.0 5wnh Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 6E9WA Q13464 9 404 1354.0 J0P:501 Type1 Inactive DFGin 5.94 12.907 ABAminus -138.73, -20.79 -111.43, 114.1 -109.17, 19.11 307.72, 100.2 -59.06, -19.52 in-in in 8.74 Saltbr-in 2.804 HRD-in -69.49, -44.89 71.41, -17.92 in-in-in SNCiii in-in ActLoopNT-in 3.053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 148.51 APE9-dihe-na 125.0, -143.28 APE8-dihe-in -119.0, 136.17 APE8-rot-in 293.48 APE67-dihe-in -80.63, -46.93 -50.48, -33.35 APE12-dist-in 11.461 APE11-dist-in 11.324 APE10-dist-in 5.617 APE9-dist-in 4.16 None None None XRAY 2.96 0.197 0.255 A 443 383 5 0 0 0 [[76, 338]] 1.0 6e9w Homo sapiens AGC_ROCK1_HUMAN AGC 4.2e-94 320.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 6E9WB Q13464 7 401 1354.0 J0P:501 Type1 Inactive DFGin 6.131 13.232 ABAminus -138.25, -17.0 -112.71, 103.23 -100.64, 12.5 302.93, 104.22 -62.68, -19.69 in-in in 8.572 Saltbr-in 2.859 HRD-in -74.05, -53.13 88.59, -33.91 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -80.59, -50.75 APE9-dihe-na 100.48, -142.0 APE8-dihe-in -66.64, 110.65 APE8-rot-in 303.29 APE67-dihe-in -27.98, -53.24 -75.85, -16.15 APE12-dist-in 9.367 APE11-dist-in 11.627 APE10-dist-out 9.912 APE9-dist-out 10.033 None None None XRAY 2.96 0.197 0.255 B 443 380 9 0 0 0 [[76, 338]] 1.0 6e9w Homo sapiens AGC_ROCK1_HUMAN AGC 4.2e-94 320.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S26D Q13464 6 399 1354.0 No_ligand No_ligand Inactive DFGin 5.74 13.393 BLAminus -135.63, 169.88 65.28, 102.89 -126.18, 46.78 310.06, 94.0 -59.95, -48.52 in-in in 8.609 Saltbr-in 2.712 HRD-out -94.12, 104.52 -83.22, 26.33 in-in-none SNCiin in-none ActLoopNT-in 3.224 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 D 398 256 101 0 0 23 [[76, 338]] 1.0 7s26 Homo sapiens AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 8ZH5A Q13464 6 402 1354.0 No_ligand No_ligand Inactive DFGin 6.201 13.812 BLAminus -163.2, 177.92 63.74, 56.57 -85.06, 72.84 297.86, 127.64 -89.2, 164.53 in-in in 8.883 Saltbr-in 3.084 HRD-out -68.24, 147.42 -129.11, 149.32 in-in-none SNCiin in-none ActLoopNT-in 3.111 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.61, -8.47 999.0, -57.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.7 0.211 0.26 A 414 381 16 0 0 5 [[76, 338]] 1.0 8zh5 Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S26A Q13464 6 401 1354.0 86K:60502 Type1 Inactive DFGin 6.073 13.254 BLAminus -148.44, 169.09 78.33, 71.17 -104.66, 28.05 312.23, 117.85 -62.26, -27.27 in-in in 8.513 Saltbr-in 2.743 HRD-in -60.15, -37.69 63.03, -7.84 in-in-out SNCiio in-out ActLoopNT-in 3.164 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.5 APE8-rot-out 189.11 APE67-dihe-in -62.34, -32.49 -61.49, -27.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 A 398 387 9 0 0 6 [[76, 338]] 1.0 7s26 Homo sapiens AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TV7A Q13464 9 402 1354.0 07Q:1 Type1 Inactive DFGin 6.141 13.462 BLAminus -126.35, -171.09 45.97, 69.47 -88.78, 8.65 301.41, 82.65 -54.6, -19.4 in-in in 8.749 Saltbr-in 2.566 HRD-out -65.46, -38.18 49.28, -142.26 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -117.48, 157.83 APE9-dihe-na -63.36, -178.67 APE8-dihe-out 60.06, 84.52 APE8-rot-out 58.98 APE67-dihe-in -61.64, -35.43 -43.45, -41.95 APE12-dist-in 11.239 APE11-dist-in 11.898 APE10-dist-in 6.024 APE9-dist-out 8.376 None None None XRAY 2.75 0.205 0.253 A 410 394 0 0 0 0 [[76, 338]] 1.0 3tv7 Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TV7B Q13464 6 402 1354.0 07Q:2 Type1 Inactive DFGin 5.857 13.2 BLAminus -126.47, -172.51 48.84, 75.23 -91.42, 11.14 311.64, 99.6 -51.14, -22.86 in-in in 8.601 Saltbr-in 2.832 HRD-in -67.51, -48.56 77.38, -23.22 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.19, 116.98 APE9-dihe-na -63.15, 117.97 APE8-dihe-out 61.18, 138.65 APE8-rot-out 58.98 APE67-dihe-in -71.45, -48.06 -97.86, 39.1 APE12-dist-out 6.296 APE11-dist-in 10.372 APE10-dist-out 8.735 APE9-dist-out 9.993 None None None XRAY 2.75 0.205 0.253 B 410 397 0 0 0 0 [[76, 338]] 1.0 3tv7 Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TV7C Q13464 9 402 1354.0 07Q:3 Type1 Inactive DFGin 5.995 13.057 BLAminus -112.83, -173.21 51.38, 70.56 -91.09, 10.07 312.0, 83.09 -58.15, -16.34 in-in in 8.646 Saltbr-in 2.603 HRD-out -60.51, -40.04 50.0, -144.78 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -114.03, 172.25 APE9-dihe-na -61.19, 179.57 APE8-dihe-out 57.96, 81.04 APE8-rot-in 298.99 APE67-dihe-in -60.89, -34.02 -49.59, -35.58 APE12-dist-in 10.411 APE11-dist-in 11.832 APE10-dist-in 5.904 APE9-dist-out 7.951 None None None XRAY 2.75 0.205 0.253 C 410 394 0 0 0 0 [[76, 338]] 1.0 3tv7 Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TV7D Q13464 6 402 1354.0 07Q:4 Type1 Inactive DFGin 6.01 13.388 BLAminus -132.56, -173.08 50.96, 76.18 -95.18, 10.41 310.62, 100.91 -52.21, -21.09 in-in in 8.623 Saltbr-in 2.97 HRD-in -71.89, -52.06 76.5, -19.27 in-in-out SNCiio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -125.31, 112.9 APE9-dihe-na -69.4, 112.01 APE8-dihe-out 62.52, 139.7 APE8-rot-in 314.53 APE67-dihe-in -45.86, -52.51 -76.31, -19.81 APE12-dist-out 5.556 APE11-dist-in 10.055 APE10-dist-out 9.448 APE9-dist-out 9.176 None None None XRAY 2.75 0.205 0.253 D 410 397 0 0 0 0 [[76, 338]] 1.0 3tv7 Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3V8SA Q13464 8 402 1354.0 0HD:501 Type1 Inactive DFGin 6.144 13.365 BLAminus -131.47, 179.47 60.6, 71.6 -93.5, 10.81 305.1, 96.77 -59.12, -15.76 in-in in 8.804 Saltbr-in 2.742 HRD-in -66.59, -53.55 76.27, -10.47 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.49, 177.7 APE9-dihe-na 96.83, -154.47 APE8-dihe-in -129.74, 143.67 APE8-rot-out 110.69 APE67-dihe-in -64.74, -31.71 -49.91, -44.47 APE12-dist-in 10.402 APE11-dist-in 11.776 APE10-dist-in 5.941 APE9-dist-in 3.727 None None None XRAY 2.286 0.188 0.236 A 410 395 0 0 0 0 [[76, 338]] 1.0 3v8s Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3V8SB Q13464 6 402 1354.0 0HD:501 Type1 Inactive DFGin 6.313 13.649 BLAminus -129.24, 179.74 58.53, 76.73 -94.51, 12.02 303.63, 98.77 -47.53, -31.19 in-in in 8.826 Saltbr-in 3.279 HRD-in -71.19, -49.28 79.11, -22.55 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -114.6, -175.49 APE9-dihe-na -78.94, -129.14 APE8-dihe-in -42.78, 130.14 APE8-rot-in 309.49 APE67-dihe-in -49.83, -43.8 -72.71, -13.77 APE12-dist-out 6.676 APE11-dist-in 10.194 APE10-dist-in 7.063 APE9-dist-out 9.407 None None None XRAY 2.286 0.188 0.236 B 410 397 0 0 0 0 [[76, 338]] 1.0 3v8s Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3V8SC Q13464 8 402 1354.0 0HD:501 Type1 Inactive DFGin 6.229 13.48 BLAminus -131.94, 178.46 61.35, 70.46 -92.71, 10.99 301.74, 97.6 -57.75, -20.03 in-in in 8.789 Saltbr-in 2.919 HRD-in -68.58, -53.3 74.86, -10.72 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.32, 170.47 APE9-dihe-na 100.83, -158.56 APE8-dihe-in -121.14, 144.0 APE8-rot-out 104.69 APE67-dihe-in -65.81, -32.6 -49.38, -42.89 APE12-dist-in 10.322 APE11-dist-in 11.73 APE10-dist-in 5.877 APE9-dist-in 3.799 None None None XRAY 2.286 0.188 0.236 C 410 395 0 0 0 0 [[76, 338]] 1.0 3v8s Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3V8SD Q13464 6 402 1354.0 0HD:501 Type1 Inactive DFGin 6.274 13.681 BLAminus -134.51, 177.57 58.27, 76.4 -93.55, 11.58 303.68, 94.09 -46.72, -30.67 in-in in 8.887 Saltbr-in 3.229 HRD-in -77.06, -45.91 77.83, -23.23 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -92.44, 115.48 APE9-dihe-na -69.73, -64.71 APE8-dihe-in -105.78, 124.29 APE8-rot-in 283.0 APE67-dihe-in -50.65, -45.32 -72.98, -15.17 APE12-dist-in 7.382 APE11-dist-in 10.194 APE10-dist-out 9.123 APE9-dist-out 9.352 None None None XRAY 2.286 0.188 0.236 D 410 397 0 0 0 0 [[76, 338]] 1.0 3v8s Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7JOUA Q13464 9 402 1354.0 VFS:4000 Type1 Inactive DFGin 5.996 13.339 BLAminus -143.11, 174.9 56.51, 84.53 -111.27, 42.13 313.94, 101.63 -66.46, -29.86 in-in in 8.585 Saltbr-in 2.649 HRD-in -50.19, -37.76 57.05, 15.82 in-in-out SNCiio in-out ActLoopNT-in 3.205 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.97, 107.53 APE9-dihe-na 156.7, 175.62 APE8-dihe-in -79.94, 144.48 APE8-rot-out 53.34 APE67-dihe-in -106.84, -34.67 -68.39, -2.9 APE12-dist-in 11.152 APE11-dist-in 12.095 APE10-dist-in 6.197 APE9-dist-in 3.941 None None None XRAY 3.318 0.218 0.248 A 413 388 6 0 0 0 [[76, 338]] 1.0 7jou Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2ESMB Q13464 6 402 1354.0 M77:60416 Type1 Inactive DFGin 6.061 13.637 BLAminus -120.7, -179.63 48.01, 93.78 -115.66, 13.56 300.62, 93.21 -64.59, 23.21 in-in in 8.7 Saltbr-in 2.809 HRD-in -64.68, -48.55 75.56, -17.87 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -120.49, 130.15 APE9-dihe-na -108.34, 137.67 APE8-dihe-out 42.68, 79.42 APE8-rot-out 61.99 APE67-dihe-in -35.68, -40.73 -70.2, -8.79 APE12-dist-in 8.402 APE11-dist-in 12.146 APE10-dist-out 11.118 APE9-dist-out 9.349 None None None XRAY 3.2 0.245 0.269 B 415 397 0 0 0 0 [[76, 338]] 1.0 2esm Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2ETKB Q13464 6 402 1354.0 HFS:60416 Type1 Inactive DFGin 6.099 14.036 BLAminus -119.07, 154.83 65.29, 101.07 -117.09, 36.18 302.09, 93.41 -68.48, -4.85 in-in in 9.089 Saltbr-in 3.243 HRD-in -65.95, -45.05 68.6, -11.17 in-in-out SNCiio in-out ActLoopNT-in 3.209 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -71.16, 135.51 APE9-dihe-na -102.49, 125.46 APE8-dihe-out 53.01, 88.66 APE8-rot-out 64.43 APE67-dihe-in -46.44, -46.86 -71.84, 0.84 APE12-dist-in 8.509 APE11-dist-in 12.745 APE10-dist-out 10.626 APE9-dist-out 9.202 None None None XRAY 2.96 0.278 0.298 B 415 397 0 0 0 0 [[76, 338]] 1.0 2etk Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 2ETRB Q13464 6 402 1354.0 Y27:60416 Type1 Inactive DFGin 5.864 13.479 BLAminus -117.79, 150.58 66.33, 120.21 -134.86, 36.11 306.16, 88.12 -76.52, 0.93 in-in in 8.686 Saltbr-in 2.752 HRD-in -64.78, -48.06 73.52, -11.25 in-in-out SNCiio in-out ActLoopNT-in 3.134 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -133.18, 138.43 APE9-dihe-na -103.78, 137.39 APE8-dihe-out 35.65, 91.86 APE8-rot-out 53.99 APE67-dihe-in -36.65, -43.6 -71.33, -4.49 APE12-dist-in 8.911 APE11-dist-in 12.333 APE10-dist-out 10.993 APE9-dist-out 9.421 None None None XRAY 2.6 0.252 0.266 B 415 397 0 0 0 0 [[76, 338]] 1.0 2etr Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3D9VB Q13464 6 402 1354.0 H52:60416 Type1 Inactive DFGin 6.233 14.285 BLAminus -106.4, 155.82 65.21, 114.96 -130.45, 38.78 300.73, 91.97 -71.81, 5.36 in-in in 9.284 Saltbr-in 3.361 HRD-in -72.68, -45.11 70.15, -5.49 in-in-out SNCiio in-out ActLoopNT-in 3.348 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -129.14, 113.22 APE9-dihe-na -106.7, 121.13 APE8-dihe-out 49.67, 80.41 APE8-rot-out 65.01 APE67-dihe-in -69.09, -34.75 -74.38, 9.95 APE12-dist-in 8.626 APE11-dist-in 11.99 APE10-dist-out 12.647 APE9-dist-out 8.602 None None None XRAY 3.3 0.262 0.28 B 415 397 0 0 0 0 [[76, 338]] 1.0 3d9v Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4YVCB Q13464 6 402 1354.0 4KH:60501 Type1 Inactive DFGin 5.987 13.03 BLAminus -134.48, 170.05 59.86, 81.37 -101.66, 32.67 304.4, 103.91 -59.54, -31.24 in-in in 8.077 Saltbr-in 2.876 HRD-in -67.8, -48.64 81.06, -11.79 in-in-out SNCiio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -102.76, 137.3 APE9-dihe-na -116.91, 99.15 APE8-dihe-out 69.44, 93.76 APE8-rot-in 303.49 APE67-dihe-in -38.38, -37.91 -75.8, -10.12 APE12-dist-in 8.33 APE11-dist-in 11.844 APE10-dist-out 10.644 APE9-dist-out 9.52 None None None XRAY 3.2 0.193 0.221 B 415 391 0 0 0 0 [[76, 338]] 1.0 4yvc Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 4YVEB Q13464 6 402 1354.0 4KK:60501 Type1 Inactive DFGin 5.949 13.034 BLAminus -142.15, 177.6 55.83, 66.0 -91.48, 48.79 310.94, 106.94 -71.74, -55.62 in-in in 8.402 Saltbr-in 2.706 HRD-in -79.37, -42.41 80.29, -49.62 in-in-out SNCiio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -118.45, 127.42 APE9-dihe-na -99.77, 159.7 APE8-dihe-out 61.11, 72.27 APE8-rot-in 329.33 APE67-dihe-in -42.85, -44.14 -72.95, -1.39 APE12-dist-in 8.194 APE11-dist-in 11.937 APE10-dist-in 7.801 APE9-dist-out 10.537 None None None XRAY 3.4 0.219 0.244 B 415 392 0 0 0 0 [[76, 338]] 1.0 4yve Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5BMLB Q13464 6 402 1354.0 4TW:60501 Type1 Inactive DFGin 6.168 12.813 BLAminus -147.33, 171.63 63.14, 85.86 -106.59, 29.54 304.93, 104.29 -62.75, -25.28 in-in in 8.166 Saltbr-in 3.067 HRD-in -63.43, -48.76 84.09, -44.69 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -95.23, 140.75 APE9-dihe-na -114.06, 93.2 APE8-dihe-out 74.29, 102.13 APE8-rot-in 315.97 APE67-dihe-in -37.39, -45.07 -85.5, -0.43 APE12-dist-in 8.479 APE11-dist-in 11.901 APE10-dist-out 10.138 APE9-dist-out 10.233 None None None XRAY 2.95 0.207 0.235 B 415 394 0 0 0 0 [[76, 338]] 1.0 5bml Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5UZJB Q13464 6 402 1354.0 8UV:60501 Type1 Inactive DFGin 6.193 13.233 BLAminus -141.66, 165.11 62.71, 74.36 -91.14, 38.13 303.19, 107.23 -56.15, -61.3 in-in in 8.556 Saltbr-in 2.669 HRD-in -70.32, -41.49 73.65, -34.67 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.09, 138.52 APE9-dihe-na -78.02, -115.28 APE8-dihe-in -91.0, 118.08 APE8-rot-out 62.39 APE67-dihe-in -38.15, -42.63 -62.29, -19.27 APE12-dist-in 8.509 APE11-dist-in 11.348 APE10-dist-out 10.742 APE9-dist-out 9.849 None None None XRAY 3.3 0.202 0.241 B 415 385 6 0 0 0 [[76, 338]] 1.0 5uzj Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TWJA Q13464 7 402 1354.0 07R:1 Type1.5_Back Inactive DFGin 5.7 13.165 BLAminus -143.98, -170.74 43.72, 70.92 -91.2, 6.87 296.12, 123.32 -47.0, -46.98 in-in in 8.565 Saltbr-in 2.723 HRD-out -68.6, -38.18 61.09, 82.09 in-in-out SNCiio in-out ActLoopNT-in 3.15 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -137.63, -171.58 APE9-dihe-na -153.4, 162.36 APE8-dihe-out 59.85, 72.82 APE8-rot-in 311.01 APE67-dihe-in -44.17, -44.94 -71.0, -20.06 APE12-dist-in 7.743 APE11-dist-in 11.217 APE10-dist-out 8.638 APE9-dist-out 9.812 None None None XRAY 2.9 0.224 0.289 A 410 396 0 0 0 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5HVUB Q13464 6 402 1354.0 65R:60501 Type1.5_Front Inactive DFGin 6.027 12.975 BLAminus -150.94, 172.97 62.5, 81.89 -105.96, 31.62 305.32, 102.48 -65.13, -10.17 in-in in 8.313 Saltbr-in 2.938 HRD-in -68.69, -52.17 76.83, -16.13 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.5 APE8-rot-out 85.32 APE67-dihe-in -36.29, -45.18 -89.86, -8.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.239 0.248 B 415 393 4 0 0 4 [[76, 338]] 1.0 5hvu Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5KKSB Q13464 6 402 1354.0 6U1:60501 Type1.5_Front Inactive DFGin 6.14 13.336 BLAminus -142.66, 177.11 58.73, 60.85 -80.32, 21.73 304.44, 101.0 -56.11, -39.34 in-in in 8.227 Saltbr-in 2.746 HRD-in -68.72, -42.28 78.49, -44.71 in-in-out SNCiio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -104.48, 133.16 APE9-dihe-na -95.73, 130.38 APE8-dihe-out 63.66, 89.81 APE8-rot-out 67.34 APE67-dihe-in -44.41, -53.62 -78.83, 5.04 APE12-dist-in 8.715 APE11-dist-in 12.174 APE10-dist-out 8.649 APE9-dist-out 10.213 None None None XRAY 3.3 0.215 0.254 B 415 394 0 0 0 0 [[76, 338]] 1.0 5kks Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5KKTB Q13464 6 402 1354.0 6U2:60501 Type1.5_Front Inactive DFGin 6.306 13.599 BLAminus -130.02, -177.11 50.1, 80.15 -95.96, 18.23 299.48, 98.02 -62.02, -10.47 in-in in 8.889 Saltbr-in 2.78 HRD-in -68.38, -47.41 71.48, -14.73 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -110.61, 86.79 APE9-dihe-na -63.17, 97.09 APE8-dihe-out 74.12, 110.85 APE8-rot-in 316.95 APE67-dihe-in -53.36, -37.05 -91.57, 10.0 APE12-dist-in 8.432 APE11-dist-in 11.357 APE10-dist-out 10.199 APE9-dist-out 9.422 None None None XRAY 2.8 0.223 0.237 B 415 393 0 0 0 0 [[76, 338]] 1.0 5kkt Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S26C Q13464 8 402 1354.0 86K:60501 Type1 Inactive DFGin 5.95 13.37 BLBminus -142.33, 179.72 55.18, 85.73 -101.52, 145.33 303.83, 102.55 -56.13, 999.0 in-in in 8.639 Saltbr-in 2.744 HRD-in -63.89, -36.06 71.41, -31.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.87 APE8-rot-out 190.89 APE67-dihe-in -62.24, -33.76 -58.59, -27.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 C 398 363 18 0 0 18 [[76, 338]] 1.0 7s26 Homo sapiens AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TWJC Q13464 7 402 1354.0 07R:2 Type1 Inactive DFGin 8.759 16.273 None -145.99, 165.67 60.97, 69.02 -57.54, -10.47 212.34, 59.8 -68.93, 18.62 in-out in 7.794 Saltbr-out 3.822 HRD-in -73.44, -64.4 76.54, -16.94 out-out-out SNCooo out-out ActLoopNT-out 3.649 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oiio APE10-dihe-na -174.55, 155.89 APE9-dihe-na -163.77, 151.18 APE8-dihe-out 67.81, 65.3 APE8-rot-in 318.87 APE67-dihe-in -61.73, -42.12 -68.66, -9.31 APE12-dist-out 6.763 APE11-dist-in 8.218 APE10-dist-in 6.246 APE9-dist-out 9.049 None None None XRAY 2.9 0.224 0.289 C 410 396 0 0 0 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TWJB Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.815 7.295 None -140.02, 177.72 -138.03, 117.9 -134.18, -179.7 267.51, 14.98 -75.11, 143.68 in-in in 8.042 Saltbr-in 3.562 HRD-in -70.23, -44.84 80.45, -14.54 in-out-out SNCioo out-out ActLoopNT-out 20.375 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.17, 145.08 APE9-dihe-na 57.93, -141.29 APE8-dihe-in -142.15, 148.38 APE8-rot-out 101.8 APE67-dihe-in -61.61, -39.57 -51.91, -51.11 APE12-dist-in 11.787 APE11-dist-in 13.034 APE10-dist-out 12.316 APE9-dist-in 4.196 None None None XRAY 2.9 0.224 0.289 B 410 395 0 0 0 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 3TWJD Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.79 6.927 None -126.16, 176.03 -134.68, 123.87 -143.34, -165.47 284.96, 15.3 -95.64, -168.75 in-in in 8.257 Saltbr-in 2.943 HRD-in -49.62, -47.32 79.16, -22.55 in-out-out SNCioo out-out ActLoopNT-out 20.397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na 45.48, 65.51 APE9-dihe-na 78.31, -176.86 APE8-dihe-in -88.74, 143.63 APE8-rot-out 17.15 APE67-dihe-in -61.11, -33.54 -55.29, -47.59 APE12-dist-in 9.993 APE11-dist-in 10.777 APE10-dist-out 10.945 APE9-dist-in 5.297 None None None XRAY 2.9 0.224 0.289 D 410 395 0 0 0 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S25A Q13464 7 401 1354.0 86G:504 Type1 Inactive DFGout 12.318 10.54 None -104.78, 156.55 -123.71, 119.26 -167.75, -177.1 52.05, 88.34 -122.16, 999.0 in-in in 8.453 Saltbr-in 2.76 HRD-in -48.48, -35.86 65.44, -17.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.37 APE8-dihe-in -84.85, 138.74 APE8-rot-in 343.84 APE67-dihe-in -53.73, -33.25 -65.56, -53.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.105 None None None XRAY 2.337 0.24 0.271 A 396 373 22 0 0 17 [[76, 338]] 1.0 7s25 Homo sapiens AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S25B Q13464 8 402 1354.0 86G:501 Type1 Inactive DFGout 12.161 10.144 None -102.96, 170.2 -133.51, 102.53 -164.51, 160.19 55.37, 93.46 -104.18, 142.28 in-in in 8.647 Saltbr-in 2.71 HRD-in -64.3, -54.36 69.65, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -102.96, -6.09 APE9-dihe-na 73.94, -123.45 APE8-dihe-in -79.15, 120.74 APE8-rot-in 312.82 APE67-dihe-in -46.47, -33.29 -85.89, -15.42 APE12-dist-in 11.32 APE11-dist-in 11.306 APE10-dist-out 9.412 APE9-dist-out 8.405 None None None XRAY 2.337 0.24 0.271 B 396 379 12 0 0 12 [[76, 338]] 1.0 7s25 Homo sapiens AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S25C Q13464 13 402 1354.0 86G:501 Type1 Inactive DFGout 12.693 10.544 None -104.89, 170.47 -133.65, 98.69 -152.01, 158.42 54.9, 83.0 -75.12, 999.0 in-in in 8.505 Saltbr-in 2.799 HRD-in -63.41, -47.95 72.04, -26.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 89.67 APE8-rot-out 72.08 APE67-dihe-in -54.43, -34.25 -48.72, -39.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.337 0.24 0.271 C 396 361 18 0 0 18 [[76, 338]] 1.0 7s25 Homo sapiens AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S25D Q13464 9 401 1354.0 No_ligand No_ligand Inactive None 999.0 999.0 None -105.32, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.472 Saltbr-in 2.733 HRD-in -82.09, -47.81 61.94, 11.48 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.337 0.24 0.271 D 396 257 113 0 0 29 [[76, 338]] 1.0 7s25 Homo sapiens AGC_ROCK1_HUMAN AGC 3e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 7S26B Q13464 6 402 1354.0 86K:60502 Type1 None DFGin 5.894 13.466 BLAminus -142.81, 170.64 62.27, 84.33 -99.22, -25.13 305.67, 98.88 -149.72, 999.0 in-in in 8.694 Saltbr-in 2.732 HRD-in -65.9, -38.81 79.64, -62.78 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.9, -32.72 999.0, -32.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 B 398 372 19 0 0 19 [[76, 338]] 1.0 7s26 Homo sapiens AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
ROCK1_HUMAN 5WNEB Q13464 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus -143.39, 177.51 52.52, 73.92 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1

AGC_ROCK1 (Rho-associated protein kinase 1)

Total number of chains: 0
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name