NEK_NEK2 (Serine/threonine-protein kinase Nek2)

Total number of chains: 31
Active chains: 2
Family: NEK
Uniprot: NEK2_HUMAN
Kinase Domain Residues: 8 - 271
Spatial label Dihedral label Number of Chains Percent Representative
None None 15 48.4% 2W5AA
DFGout None 6 19.4% 2XNPA
DFGin None 5 16.1% 5M51A
DFGin BLAminus 2 6.5% AF-P51955-K1A
DFGinter None 2 6.5% 2W5BA
DFGin BLBminus 1 3.2% 5M53A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P51955-K1A 1 279 445.0 No_ligand No_ligand Active DFGin 6.869 14.633 BLAminus -133.95, -173.4 54.79, 72.42 -82.83, 18.74 289.02, 77.16 -61.4, -26.12 out-in out 10.002 Saltbr-in 3.279 HRD-in -72.13, -45.55 64.71, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 153.79 APE9-dihe-na 121.29, 162.72 APE8-dihe-in -74.75, 126.9 APE8-rot-in 300.51 APE67-dihe-in -70.7, -19.6 -51.47, -35.98 APE12-dist-in 8.99 APE11-dist-in 12.023 APE10-dist-in 6.045 APE9-dist-in 3.386 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[8, 271]] 1.0 AF-P51955-K1 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
AF-P51955-K3A 1 279 445.0 No_ligand No_ligand Active DFGin 6.974 14.518 BLAminus -137.03, -171.55 54.92, 64.89 -76.15, 14.43 291.41, 82.24 -62.84, -23.1 in-in in 9.438 Saltbr-in 3.249 HRD-in -75.06, -47.19 67.7, -5.95 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 154.63 APE9-dihe-na 115.59, 177.84 APE8-dihe-in -86.96, 123.76 APE8-rot-in 298.85 APE67-dihe-in -69.6, -21.35 -53.86, -31.33 APE12-dist-in 9.054 APE11-dist-in 11.879 APE10-dist-in 5.958 APE9-dist-in 3.308 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[8, 271]] 1.0 AF-P51955-K3 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
5M53A 7 271 445.0 7GJ:60301 Type1 Inactive DFGin 6.93 14.378 BLBminus -144.16, -170.37 48.32, 59.88 -59.99, 141.64 280.06, 65.68 -69.25, 124.97 out-out out 12.196 Saltbr-out 14.973 HRD-in -71.9, -49.61 75.14, -3.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 161.13 APE9-dihe-na -132.97, 40.41 APE8-dihe-in -118.33, 141.27 APE8-rot-out 188.95 APE67-dihe-in -55.4, -27.59 -60.61, -29.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.895 APE9-dist-out 15.829 None None None XRAY 1.9 0.198 0.235 A 279 248 17 0 0 14 [[8, 271]] 1.0 5m53 NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XKDA 3 271 445.0 T3M:61280 Type1 Inactive DFGin 7.782 14.721 None -118.6, -157.91 42.92, 77.2 -104.57, 999.0 308.02, 95.14 999.0, 999.0 out-out out 12.519 Saltbr-out 9.174 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 73.57, -54.62 APE9-dihe-na -57.09, 148.53 APE8-dihe-in -95.98, 122.75 APE8-rot-in 312.67 APE67-dihe-out -54.02, -37.1 -77.53, 67.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.183 0.217 A 279 243 26 0 0 14 [[8, 271]] 1.0 2xkd NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XKEA 3 271 445.0 WI2:61280 Type1 Inactive DFGin 7.78 14.674 None -126.61, -154.27 59.66, -98.99 82.09, 999.0 300.47, 105.7 999.0, 999.0 out-out out 12.155 Saltbr-out 8.56 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 108.7 APE8-rot-in 350.6 APE67-dihe-out -48.98, -38.02 -83.19, 66.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.203 0.178 0.226 A 279 235 34 0 0 18 [[8, 271]] 1.0 2xke NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XKFA 3 271 445.0 BX1:61280 Type1 Inactive DFGin 8.024 14.793 None -136.65, 176.84 62.75, 83.47 -107.53, 999.0 295.67, 92.44 999.0, 999.0 out-out out 12.097 Saltbr-out 8.669 HRD-none 999.0, 999.0 999.0, -165.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -96.76, -179.12 APE9-dihe-na 106.62, 145.4 APE8-dihe-in -83.33, 139.63 APE8-rot-out 49.39 APE67-dihe-out -45.16, -35.54 -81.58, 70.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.855 None None None XRAY 2.35 0.174 0.222 A 279 242 27 0 0 15 [[8, 271]] 1.0 2xkf NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
5M51A 3 271 445.0 NU6:60301 Type1 Inactive DFGin 6.917 15.033 None -135.97, -170.98 47.05, 66.56 -67.3, 999.0 280.24, 65.86 999.0, 999.0 out-none out 13.328 Saltbr-none 999.0 HRD-in -68.55, -48.07 77.08, -5.68 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -15.98 APE9-dihe-na -61.81, 166.03 APE8-dihe-in -100.33, 135.8 APE8-rot-out 177.14 APE67-dihe-out -48.68, -33.32 -89.41, 73.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.15 None None None XRAY 1.899 0.224 0.257 A 279 253 16 0 0 16 [[8, 271]] 1.0 5m51 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
5M57A 3 271 445.0 4SP:60301 Type1 Inactive DFGin 6.857 14.905 None -135.46, -174.37 50.79, 73.32 -79.95, 999.0 289.86, 69.03 999.0, 999.0 out-none out 13.167 Saltbr-none 999.0 HRD-in -67.32, -45.79 72.98, 0.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -18.35 APE9-dihe-na -78.84, 166.93 APE8-dihe-in -97.45, 140.37 APE8-rot-out 196.13 APE67-dihe-out -44.71, -40.0 -94.19, 69.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.266 None None None XRAY 2.3 0.221 0.274 A 279 253 16 0 0 16 [[8, 271]] 1.0 5m57 NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2W5BA 3 271 445.0 AGS:61280 ATPlike Inactive DFGinter 8.504 5.693 None -133.84, 63.71 -87.34, 106.84 -95.06, 50.42 207.49, 72.2 -49.75, -30.44 out-out out 12.589 Saltbr-out 12.763 HRD-out -82.64, 121.7 -138.12, 47.77 out-out-out SNCooo out-out ActLoopNT-out 12.438 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -74.41, -42.54 APE9-dihe-na -62.33, 153.14 APE8-dihe-in -108.21, 120.03 APE8-rot-in 313.31 APE67-dihe-out -53.46, -34.47 -75.96, 66.07 APE12-dist-out 14.06 APE11-dist-out 18.785 APE10-dist-out 19.398 APE9-dist-out 15.879 T175A None None XRAY 2.4 0.186 0.245 A 279 263 6 0 0 0 [[8, 271]] 1.0 2w5b NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2W5HA 3 271 445.0 No_ligand No_ligand Inactive DFGinter 8.853 5.406 None -145.64, 64.76 -76.5, 122.71 -111.22, 47.01 200.36, 74.35 -55.33, -23.57 out-none out 12.526 Saltbr-none 999.0 HRD-none 999.0, 88.49 -140.73, 52.97 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -80.98, -33.57 APE9-dihe-na -66.5, 141.66 APE8-dihe-in -95.51, 126.28 APE8-rot-in 311.21 APE67-dihe-out -49.54, -31.25 -80.26, 60.18 APE12-dist-in 13.999 APE11-dist-out 18.643 APE10-dist-out 19.67 APE9-dist-out 16.136 T175A None None XRAY 2.33 0.197 0.254 A 279 257 12 0 0 3 [[8, 271]] 1.0 2w5h NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XK3A 3 271 445.0 XK3:61280 Type1 Inactive DFGout 13.998 10.364 None -94.01, -173.78 -100.74, -8.48 -116.44, 79.34 59.9, 126.44 109.72, 999.0 out-out out 12.625 Saltbr-out 6.379 HRD-none 999.0, 999.0 999.0, 142.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, -35.65 APE9-dihe-na -70.11, 160.42 APE8-dihe-in -81.78, 133.65 APE8-rot-in 317.65 APE67-dihe-out -51.15, -31.98 -82.01, 68.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.909 None None None XRAY 2.2 0.188 0.238 A 279 239 30 0 0 15 [[8, 271]] 1.0 2xk3 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XK4A 3 271 445.0 OL2:61280 Type1 Inactive DFGout 14.031 9.708 None -87.38, -167.87 -104.54, 4.45 -54.69, 129.92 290.54, 144.18 106.05, -17.19 out-out out 11.808 Saltbr-out 8.053 HRD-none 999.0, 999.0 999.0, 129.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -58.86, -39.55 APE9-dihe-na -73.8, 155.61 APE8-dihe-in -81.1, 132.85 APE8-rot-in 320.85 APE67-dihe-out -49.69, -33.89 -82.22, 64.47 APE12-dist-none 999.0 APE11-dist-out 17.27 APE10-dist-out 19.616 APE9-dist-out 16.675 None None None XRAY 2.1 0.17 0.211 A 279 244 25 0 0 13 [[8, 271]] 1.0 2xk4 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XK8A 3 271 445.0 5R1:61280 Type1 Inactive DFGout 15.621 9.394 None -105.04, -149.29 -166.14, 83.41 -68.6, 999.0 260.91, 73.69 999.0, 999.0 out-out out 12.455 Saltbr-out 8.429 HRD-none 999.0, 999.0 999.0, 110.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -64.25, -38.55 APE9-dihe-na -69.95, 152.06 APE8-dihe-in -83.61, 130.25 APE8-rot-in 323.79 APE67-dihe-out -52.57, -33.44 -80.5, 68.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.531 None None None XRAY 2.001 0.175 0.214 A 279 238 31 0 0 15 [[8, 271]] 1.0 2xk8 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XNPA 3 271 445.0 WCX:61280 Type1 Inactive DFGout 13.945 10.411 None -95.34, -164.16 -102.38, 5.78 -53.48, 134.48 283.48, 136.9 83.7, -21.35 out-out out 11.498 Saltbr-out 7.81 HRD-none 999.0, 134.96 -87.57, 130.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -60.95, -36.05 APE9-dihe-na -70.15, 150.69 APE8-dihe-in -79.88, 132.39 APE8-rot-in 313.66 APE67-dihe-out -46.38, -35.72 -83.7, 65.57 APE12-dist-none 999.0 APE11-dist-out 17.683 APE10-dist-out 20.052 APE9-dist-out 16.882 None None None XRAY 1.98 0.159 0.201 A 279 245 24 0 0 13 [[8, 271]] 1.0 2xnp NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
4AFEA 3 271 445.0 GGY:61280 Type1 Inactive DFGout 14.348 10.088 None -88.82, -167.33 -104.39, -6.76 -46.94, 133.49 287.32, 135.97 83.67, -6.27 out-out out 11.806 Saltbr-out 8.119 HRD-none 999.0, -123.63 -75.84, 145.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, -46.02 APE9-dihe-na -71.45, 162.02 APE8-dihe-in -84.1, 122.47 APE8-rot-out 1.22 APE67-dihe-out -49.39, -28.09 -75.02, 68.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.088 APE9-dist-out 17.36 None None None XRAY 2.597 0.218 0.248 A 279 245 24 0 0 14 [[8, 271]] 1.0 4afe NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
4A4XA 3 271 445.0 JUP:61280 Type1 Inactive DFGout 14.21 10.389 None -94.03, -162.78 -102.04, 4.6 -57.63, 130.73 286.38, 126.25 93.44, -18.4 out-out out 11.655 Saltbr-out 8.088 HRD-none 999.0, -136.51 -57.11, 154.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -43.75 APE9-dihe-na -89.05, 158.14 APE8-dihe-in -68.0, 130.88 APE8-rot-in 354.45 APE67-dihe-out -46.92, -33.17 -84.14, 68.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.402 APE9-dist-out 17.787 T170E,S171D,T175E None None XRAY 2.4 0.206 0.247 A 279 245 24 0 0 14 [[8, 271]] 1.0 4a4x NEK_NEK2_HUMAN NEK 1.8e-108 367.8 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2W5AA 3 271 445.0 ADP:61280 ATPlike Inactive None 12.645 15.915 None -79.34, 164.62 -62.62, 148.1 -64.74, -38.56 187.15, 76.57 112.78, 109.44 out-out out 13.134 Saltbr-out 14.422 HRD-out -72.83, 129.73 -137.0, 151.51 out-out-out SNCooo out-out ActLoopNT-out 11.638 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -50.6, -46.29 APE9-dihe-na -59.22, 149.78 APE8-dihe-in -97.74, 124.68 APE8-rot-in 301.95 APE67-dihe-out -55.08, -31.55 -81.03, 66.49 APE12-dist-out 14.668 APE11-dist-out 19.148 APE10-dist-out 20.029 APE9-dist-out 14.901 None None None XRAY 1.55 0.173 0.19 A 279 259 10 0 0 3 [[8, 271]] 1.0 2w5a NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2WQOA 3 271 445.0 VGK:61280 Type1 Inactive None 999.0 999.0 None -114.77, -150.42 25.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.55 Saltbr-out 8.893 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.84 APE8-dihe-in -72.38, 127.66 APE8-rot-in 335.48 APE67-dihe-out -51.52, -31.7 -82.04, 68.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.167 0.186 0.235 A 279 234 35 0 0 18 [[8, 271]] 1.0 2wqo NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XK6A 4 271 445.0 EQH:61280 Type1 Inactive None 999.0 999.0 None -96.59, -164.58 -118.88, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.235 Saltbr-out 8.608 HRD-none 999.0, 999.0 999.0, 106.86 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, -42.56 APE9-dihe-na -89.89, 167.71 APE8-dihe-in -80.91, 129.71 APE8-rot-in 320.43 APE67-dihe-out -53.69, -32.79 -80.63, 68.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.838 None None None XRAY 2.2 0.181 0.218 A 279 235 33 0 0 17 [[8, 271]] 1.0 2xk6 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XK7A 3 271 445.0 30E:61280 Type1 Inactive None 999.0 999.0 None -99.88, -153.34 -139.71, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 11.746 Saltbr-out 7.645 HRD-none 999.0, 999.0 999.0, 92.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -62.05, -40.96 APE9-dihe-na -69.94, 151.91 APE8-dihe-in -81.96, 133.02 APE8-rot-in 328.84 APE67-dihe-out -49.56, -33.29 -82.54, 66.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.823 None None None XRAY 1.992 0.177 0.225 A 279 238 31 0 0 16 [[8, 271]] 1.0 2xk7 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XKCA 3 271 445.0 4VQ:61280 Type1 Inactive None 999.0 999.0 None -146.1, 141.6 -81.15, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 13.072 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.5 APE8-dihe-in -79.55, 123.42 APE8-rot-in 322.72 APE67-dihe-out -54.8, -33.59 -82.51, 67.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.189 0.235 A 279 236 33 0 0 18 [[8, 271]] 1.0 2xkc NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XNMA 3 271 445.0 WGZ:61280 Type1 Inactive None 16.21 14.371 None -87.64, -171.68 -108.95, 105.05 -67.63, -12.76 198.1, 63.93 -63.37, -25.8 out-out out 11.571 Saltbr-out 13.696 HRD-none 999.0, 999.0 999.0, 77.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -64.71, -31.88 APE9-dihe-na -63.26, 151.77 APE8-dihe-in -90.68, 129.66 APE8-rot-in 310.46 APE67-dihe-out -52.48, -35.0 -82.15, 65.34 APE12-dist-none 999.0 APE11-dist-out 17.869 APE10-dist-out 18.9 APE9-dist-out 17.322 None None None XRAY 1.85 0.165 0.196 A 279 250 19 0 0 9 [[8, 271]] 1.0 2xnm NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XNNA 3 271 445.0 430:61280 Type1 Inactive None 999.0 999.0 None -93.41, -163.63 -136.68, 147.69 -84.21, 109.73 999.0, 999.0 -141.51, 999.0 out-none out 11.879 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 109.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -58.61, -43.2 APE9-dihe-na -68.9, 142.68 APE8-dihe-in -88.53, 134.59 APE8-rot-out 22.42 APE67-dihe-out -53.23, -34.18 -85.97, 72.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.628 None None None XRAY 2.5 0.175 0.237 A 279 243 26 0 0 14 [[8, 271]] 1.0 2xnn NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2XNOA 3 271 445.0 ED8:61280 Type1 Inactive None 999.0 999.0 None -88.02, 167.37 -92.45, -174.51 -179.28, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.314 Saltbr-out 13.595 HRD-none 999.0, 999.0 999.0, 87.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -60.04, -40.41 APE9-dihe-na -64.39, 152.02 APE8-dihe-in -91.7, 128.47 APE8-rot-in 314.42 APE67-dihe-out -53.73, -32.82 -80.68, 66.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.69 None None None XRAY 1.98 0.172 0.214 A 279 243 26 0 0 15 [[8, 271]] 1.0 2xno NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
5M55A 3 271 445.0 7GG:60301 Type1 Inactive None 999.0 999.0 None -114.19, -135.1 -178.71, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.381 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.78 APE8-rot-out 202.77 APE67-dihe-out -53.34, -31.96 -91.76, 69.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.191 0.249 A 279 232 37 0 0 19 [[8, 271]] 1.0 5m55 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
6SGDA 3 271 445.0 LD5:60304 Type1 Inactive None 999.0 999.0 None -127.67, 170.43 62.02, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.071 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 999.0, -46.25 APE9-dihe-na -98.23, 161.49 APE8-dihe-in -73.88, 123.98 APE8-rot-in 325.25 APE67-dihe-out -60.94, -25.35 -80.76, 75.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.2 0.234 A 279 240 29 0 0 17 [[8, 271]] 1.0 6sgd NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
6SGHA 3 271 445.0 LCW:60301 Type1 Inactive None 999.0 999.0 None -170.33, 169.0 -77.31, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.147 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -30.5 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.23 0.29 A 279 230 39 0 0 21 [[8, 271]] 1.0 6sgh NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
6SGIA 3 271 445.0 LCB:60301 Type1 Inactive None 999.0 999.0 None -99.2, 164.85 -97.27, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.568 Saltbr-out 12.267 HRD-none 999.0, 112.82 -122.18, -174.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -108.16, -24.32 APE9-dihe-na -78.79, 148.96 APE8-dihe-in -71.64, 136.44 APE8-rot-in 324.51 APE67-dihe-out -63.23, -22.68 -80.23, 81.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.151 None None None XRAY 2.3 0.216 0.266 A 279 244 25 0 0 16 [[8, 271]] 1.0 6sgi NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
6SGKA 3 271 445.0 LCQ:60301 Type1 Inactive None 999.0 999.0 None -109.89, -152.44 174.9, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.514 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na -78.19, -29.68 APE9-dihe-na -72.58, 155.55 APE8-dihe-in -95.97, 127.89 APE8-rot-in 324.86 APE67-dihe-out -58.29, -30.48 -74.01, 72.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.197 0.223 A 279 239 30 0 0 16 [[8, 271]] 1.0 6sgk NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
6SK9A 4 271 445.0 F9N:60301 Type1 Inactive None 999.0 999.0 None -95.31, 177.22 48.53, 40.4 -138.88, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.371 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 79.29 APE8-dihe-in -99.35, 119.5 APE8-rot-out 165.62 APE67-dihe-out -52.47, -29.05 -77.36, 72.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.19 0.22 A 279 232 36 0 0 17 [[8, 271]] 1.0 6sk9 NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
2JAVA 3 271 445.0 5Z5:61280 Type1 Inactive None 12.445 19.007 None -67.88, 137.1 -47.89, 123.79 -62.34, -34.41 294.47, 133.99 -68.12, -29.67 out-out out 11.812 Saltbr-out 14.791 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.9 APE8-dihe-out -80.72, -38.69 APE8-rot-out 190.2 APE67-dihe-out 67.83, -49.58 -75.41, -43.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T175A None None XRAY 2.2 0.217 0.277 A 279 245 24 0 0 11 [[8, 271]] 1.0 2jav NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2

NEK_NEK2 (Serine/threonine-protein kinase Nek2)

Total number of chains: 31
Active chains: 2
Family: NEK
Spatial label Dihedral label Number of Chains Percent Representative
None None 15 48.4% 2W5AA
DFGout None 6 19.4% 2XNPA
DFGin None 5 16.1% 5M51A
DFGin BLAminus 2 6.5% AF-P51955-K1A
DFGinter None 2 6.5% 2W5BA
DFGin BLBminus 1 3.2% 5M53A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NEK2_HUMAN AF-P51955-K1A P51955 1 279 445.0 No_ligand No_ligand Active DFGin 6.869 14.633 BLAminus -133.95, -173.4 54.79, 72.42 -82.83, 18.74 289.02, 77.16 -61.4, -26.12 out-in out 10.002 Saltbr-in 3.279 HRD-in -72.13, -45.55 64.71, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 153.79 APE9-dihe-na 121.29, 162.72 APE8-dihe-in -74.75, 126.9 APE8-rot-in 300.51 APE67-dihe-in -70.7, -19.6 -51.47, -35.98 APE12-dist-in 8.99 APE11-dist-in 12.023 APE10-dist-in 6.045 APE9-dist-in 3.386 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[8, 271]] 1.0 AF-P51955-K1 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN AF-P51955-K3A P51955 1 279 445.0 No_ligand No_ligand Active DFGin 6.974 14.518 BLAminus -137.03, -171.55 54.92, 64.89 -76.15, 14.43 291.41, 82.24 -62.84, -23.1 in-in in 9.438 Saltbr-in 3.249 HRD-in -75.06, -47.19 67.7, -5.95 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 154.63 APE9-dihe-na 115.59, 177.84 APE8-dihe-in -86.96, 123.76 APE8-rot-in 298.85 APE67-dihe-in -69.6, -21.35 -53.86, -31.33 APE12-dist-in 9.054 APE11-dist-in 11.879 APE10-dist-in 5.958 APE9-dist-in 3.308 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[8, 271]] 1.0 AF-P51955-K3 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 5M53A P51955 7 271 445.0 7GJ:60301 Type1 Inactive DFGin 6.93 14.378 BLBminus -144.16, -170.37 48.32, 59.88 -59.99, 141.64 280.06, 65.68 -69.25, 124.97 out-out out 12.196 Saltbr-out 14.973 HRD-in -71.9, -49.61 75.14, -3.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 161.13 APE9-dihe-na -132.97, 40.41 APE8-dihe-in -118.33, 141.27 APE8-rot-out 188.95 APE67-dihe-in -55.4, -27.59 -60.61, -29.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.895 APE9-dist-out 15.829 None None None XRAY 1.9 0.198 0.235 A 279 248 17 0 0 14 [[8, 271]] 1.0 5m53 Homo sapiens NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XKDA P51955 3 271 445.0 T3M:61280 Type1 Inactive DFGin 7.782 14.721 None -118.6, -157.91 42.92, 77.2 -104.57, 999.0 308.02, 95.14 999.0, 999.0 out-out out 12.519 Saltbr-out 9.174 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 73.57, -54.62 APE9-dihe-na -57.09, 148.53 APE8-dihe-in -95.98, 122.75 APE8-rot-in 312.67 APE67-dihe-out -54.02, -37.1 -77.53, 67.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.183 0.217 A 279 243 26 0 0 14 [[8, 271]] 1.0 2xkd Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XKEA P51955 3 271 445.0 WI2:61280 Type1 Inactive DFGin 7.78 14.674 None -126.61, -154.27 59.66, -98.99 82.09, 999.0 300.47, 105.7 999.0, 999.0 out-out out 12.155 Saltbr-out 8.56 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 108.7 APE8-rot-in 350.6 APE67-dihe-out -48.98, -38.02 -83.19, 66.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.203 0.178 0.226 A 279 235 34 0 0 18 [[8, 271]] 1.0 2xke Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XKFA P51955 3 271 445.0 BX1:61280 Type1 Inactive DFGin 8.024 14.793 None -136.65, 176.84 62.75, 83.47 -107.53, 999.0 295.67, 92.44 999.0, 999.0 out-out out 12.097 Saltbr-out 8.669 HRD-none 999.0, 999.0 999.0, -165.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -96.76, -179.12 APE9-dihe-na 106.62, 145.4 APE8-dihe-in -83.33, 139.63 APE8-rot-out 49.39 APE67-dihe-out -45.16, -35.54 -81.58, 70.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.855 None None None XRAY 2.35 0.174 0.222 A 279 242 27 0 0 15 [[8, 271]] 1.0 2xkf Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 5M51A P51955 3 271 445.0 NU6:60301 Type1 Inactive DFGin 6.917 15.033 None -135.97, -170.98 47.05, 66.56 -67.3, 999.0 280.24, 65.86 999.0, 999.0 out-none out 13.328 Saltbr-none 999.0 HRD-in -68.55, -48.07 77.08, -5.68 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -15.98 APE9-dihe-na -61.81, 166.03 APE8-dihe-in -100.33, 135.8 APE8-rot-out 177.14 APE67-dihe-out -48.68, -33.32 -89.41, 73.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.15 None None None XRAY 1.899 0.224 0.257 A 279 253 16 0 0 16 [[8, 271]] 1.0 5m51 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 5M57A P51955 3 271 445.0 4SP:60301 Type1 Inactive DFGin 6.857 14.905 None -135.46, -174.37 50.79, 73.32 -79.95, 999.0 289.86, 69.03 999.0, 999.0 out-none out 13.167 Saltbr-none 999.0 HRD-in -67.32, -45.79 72.98, 0.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, -18.35 APE9-dihe-na -78.84, 166.93 APE8-dihe-in -97.45, 140.37 APE8-rot-out 196.13 APE67-dihe-out -44.71, -40.0 -94.19, 69.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.266 None None None XRAY 2.3 0.221 0.274 A 279 253 16 0 0 16 [[8, 271]] 1.0 5m57 Homo sapiens NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2W5BA P51955 3 271 445.0 AGS:61280 ATPlike Inactive DFGinter 8.504 5.693 None -133.84, 63.71 -87.34, 106.84 -95.06, 50.42 207.49, 72.2 -49.75, -30.44 out-out out 12.589 Saltbr-out 12.763 HRD-out -82.64, 121.7 -138.12, 47.77 out-out-out SNCooo out-out ActLoopNT-out 12.438 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -74.41, -42.54 APE9-dihe-na -62.33, 153.14 APE8-dihe-in -108.21, 120.03 APE8-rot-in 313.31 APE67-dihe-out -53.46, -34.47 -75.96, 66.07 APE12-dist-out 14.06 APE11-dist-out 18.785 APE10-dist-out 19.398 APE9-dist-out 15.879 T175A None None XRAY 2.4 0.186 0.245 A 279 263 6 0 0 0 [[8, 271]] 1.0 2w5b Homo sapiens NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2W5HA P51955 3 271 445.0 No_ligand No_ligand Inactive DFGinter 8.853 5.406 None -145.64, 64.76 -76.5, 122.71 -111.22, 47.01 200.36, 74.35 -55.33, -23.57 out-none out 12.526 Saltbr-none 999.0 HRD-none 999.0, 88.49 -140.73, 52.97 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -80.98, -33.57 APE9-dihe-na -66.5, 141.66 APE8-dihe-in -95.51, 126.28 APE8-rot-in 311.21 APE67-dihe-out -49.54, -31.25 -80.26, 60.18 APE12-dist-in 13.999 APE11-dist-out 18.643 APE10-dist-out 19.67 APE9-dist-out 16.136 T175A None None XRAY 2.33 0.197 0.254 A 279 257 12 0 0 3 [[8, 271]] 1.0 2w5h Homo sapiens NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XK3A P51955 3 271 445.0 XK3:61280 Type1 Inactive DFGout 13.998 10.364 None -94.01, -173.78 -100.74, -8.48 -116.44, 79.34 59.9, 126.44 109.72, 999.0 out-out out 12.625 Saltbr-out 6.379 HRD-none 999.0, 999.0 999.0, 142.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, -35.65 APE9-dihe-na -70.11, 160.42 APE8-dihe-in -81.78, 133.65 APE8-rot-in 317.65 APE67-dihe-out -51.15, -31.98 -82.01, 68.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.909 None None None XRAY 2.2 0.188 0.238 A 279 239 30 0 0 15 [[8, 271]] 1.0 2xk3 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XK4A P51955 3 271 445.0 OL2:61280 Type1 Inactive DFGout 14.031 9.708 None -87.38, -167.87 -104.54, 4.45 -54.69, 129.92 290.54, 144.18 106.05, -17.19 out-out out 11.808 Saltbr-out 8.053 HRD-none 999.0, 999.0 999.0, 129.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -58.86, -39.55 APE9-dihe-na -73.8, 155.61 APE8-dihe-in -81.1, 132.85 APE8-rot-in 320.85 APE67-dihe-out -49.69, -33.89 -82.22, 64.47 APE12-dist-none 999.0 APE11-dist-out 17.27 APE10-dist-out 19.616 APE9-dist-out 16.675 None None None XRAY 2.1 0.17 0.211 A 279 244 25 0 0 13 [[8, 271]] 1.0 2xk4 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XK8A P51955 3 271 445.0 5R1:61280 Type1 Inactive DFGout 15.621 9.394 None -105.04, -149.29 -166.14, 83.41 -68.6, 999.0 260.91, 73.69 999.0, 999.0 out-out out 12.455 Saltbr-out 8.429 HRD-none 999.0, 999.0 999.0, 110.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -64.25, -38.55 APE9-dihe-na -69.95, 152.06 APE8-dihe-in -83.61, 130.25 APE8-rot-in 323.79 APE67-dihe-out -52.57, -33.44 -80.5, 68.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.531 None None None XRAY 2.001 0.175 0.214 A 279 238 31 0 0 15 [[8, 271]] 1.0 2xk8 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XNPA P51955 3 271 445.0 WCX:61280 Type1 Inactive DFGout 13.945 10.411 None -95.34, -164.16 -102.38, 5.78 -53.48, 134.48 283.48, 136.9 83.7, -21.35 out-out out 11.498 Saltbr-out 7.81 HRD-none 999.0, 134.96 -87.57, 130.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -60.95, -36.05 APE9-dihe-na -70.15, 150.69 APE8-dihe-in -79.88, 132.39 APE8-rot-in 313.66 APE67-dihe-out -46.38, -35.72 -83.7, 65.57 APE12-dist-none 999.0 APE11-dist-out 17.683 APE10-dist-out 20.052 APE9-dist-out 16.882 None None None XRAY 1.98 0.159 0.201 A 279 245 24 0 0 13 [[8, 271]] 1.0 2xnp Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 4AFEA P51955 3 271 445.0 GGY:61280 Type1 Inactive DFGout 14.348 10.088 None -88.82, -167.33 -104.39, -6.76 -46.94, 133.49 287.32, 135.97 83.67, -6.27 out-out out 11.806 Saltbr-out 8.119 HRD-none 999.0, -123.63 -75.84, 145.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, -46.02 APE9-dihe-na -71.45, 162.02 APE8-dihe-in -84.1, 122.47 APE8-rot-out 1.22 APE67-dihe-out -49.39, -28.09 -75.02, 68.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.088 APE9-dist-out 17.36 None None None XRAY 2.597 0.218 0.248 A 279 245 24 0 0 14 [[8, 271]] 1.0 4afe Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 4A4XA P51955 3 271 445.0 JUP:61280 Type1 Inactive DFGout 14.21 10.389 None -94.03, -162.78 -102.04, 4.6 -57.63, 130.73 286.38, 126.25 93.44, -18.4 out-out out 11.655 Saltbr-out 8.088 HRD-none 999.0, -136.51 -57.11, 154.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -43.75 APE9-dihe-na -89.05, 158.14 APE8-dihe-in -68.0, 130.88 APE8-rot-in 354.45 APE67-dihe-out -46.92, -33.17 -84.14, 68.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.402 APE9-dist-out 17.787 T170E,S171D,T175E None None XRAY 2.4 0.206 0.247 A 279 245 24 0 0 14 [[8, 271]] 1.0 4a4x Homo sapiens NEK_NEK2_HUMAN NEK 1.8e-108 367.8 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2W5AA P51955 3 271 445.0 ADP:61280 ATPlike Inactive None 12.645 15.915 None -79.34, 164.62 -62.62, 148.1 -64.74, -38.56 187.15, 76.57 112.78, 109.44 out-out out 13.134 Saltbr-out 14.422 HRD-out -72.83, 129.73 -137.0, 151.51 out-out-out SNCooo out-out ActLoopNT-out 11.638 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -50.6, -46.29 APE9-dihe-na -59.22, 149.78 APE8-dihe-in -97.74, 124.68 APE8-rot-in 301.95 APE67-dihe-out -55.08, -31.55 -81.03, 66.49 APE12-dist-out 14.668 APE11-dist-out 19.148 APE10-dist-out 20.029 APE9-dist-out 14.901 None None None XRAY 1.55 0.173 0.19 A 279 259 10 0 0 3 [[8, 271]] 1.0 2w5a Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2WQOA P51955 3 271 445.0 VGK:61280 Type1 Inactive None 999.0 999.0 None -114.77, -150.42 25.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.55 Saltbr-out 8.893 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.84 APE8-dihe-in -72.38, 127.66 APE8-rot-in 335.48 APE67-dihe-out -51.52, -31.7 -82.04, 68.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.167 0.186 0.235 A 279 234 35 0 0 18 [[8, 271]] 1.0 2wqo Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XK6A P51955 4 271 445.0 EQH:61280 Type1 Inactive None 999.0 999.0 None -96.59, -164.58 -118.88, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.235 Saltbr-out 8.608 HRD-none 999.0, 999.0 999.0, 106.86 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, -42.56 APE9-dihe-na -89.89, 167.71 APE8-dihe-in -80.91, 129.71 APE8-rot-in 320.43 APE67-dihe-out -53.69, -32.79 -80.63, 68.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.838 None None None XRAY 2.2 0.181 0.218 A 279 235 33 0 0 17 [[8, 271]] 1.0 2xk6 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XK7A P51955 3 271 445.0 30E:61280 Type1 Inactive None 999.0 999.0 None -99.88, -153.34 -139.71, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 11.746 Saltbr-out 7.645 HRD-none 999.0, 999.0 999.0, 92.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -62.05, -40.96 APE9-dihe-na -69.94, 151.91 APE8-dihe-in -81.96, 133.02 APE8-rot-in 328.84 APE67-dihe-out -49.56, -33.29 -82.54, 66.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.823 None None None XRAY 1.992 0.177 0.225 A 279 238 31 0 0 16 [[8, 271]] 1.0 2xk7 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XKCA P51955 3 271 445.0 4VQ:61280 Type1 Inactive None 999.0 999.0 None -146.1, 141.6 -81.15, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 13.072 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.5 APE8-dihe-in -79.55, 123.42 APE8-rot-in 322.72 APE67-dihe-out -54.8, -33.59 -82.51, 67.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.189 0.235 A 279 236 33 0 0 18 [[8, 271]] 1.0 2xkc Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XNMA P51955 3 271 445.0 WGZ:61280 Type1 Inactive None 16.21 14.371 None -87.64, -171.68 -108.95, 105.05 -67.63, -12.76 198.1, 63.93 -63.37, -25.8 out-out out 11.571 Saltbr-out 13.696 HRD-none 999.0, 999.0 999.0, 77.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -64.71, -31.88 APE9-dihe-na -63.26, 151.77 APE8-dihe-in -90.68, 129.66 APE8-rot-in 310.46 APE67-dihe-out -52.48, -35.0 -82.15, 65.34 APE12-dist-none 999.0 APE11-dist-out 17.869 APE10-dist-out 18.9 APE9-dist-out 17.322 None None None XRAY 1.85 0.165 0.196 A 279 250 19 0 0 9 [[8, 271]] 1.0 2xnm Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XNNA P51955 3 271 445.0 430:61280 Type1 Inactive None 999.0 999.0 None -93.41, -163.63 -136.68, 147.69 -84.21, 109.73 999.0, 999.0 -141.51, 999.0 out-none out 11.879 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 109.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -58.61, -43.2 APE9-dihe-na -68.9, 142.68 APE8-dihe-in -88.53, 134.59 APE8-rot-out 22.42 APE67-dihe-out -53.23, -34.18 -85.97, 72.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.628 None None None XRAY 2.5 0.175 0.237 A 279 243 26 0 0 14 [[8, 271]] 1.0 2xnn Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2XNOA P51955 3 271 445.0 ED8:61280 Type1 Inactive None 999.0 999.0 None -88.02, 167.37 -92.45, -174.51 -179.28, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.314 Saltbr-out 13.595 HRD-none 999.0, 999.0 999.0, 87.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -60.04, -40.41 APE9-dihe-na -64.39, 152.02 APE8-dihe-in -91.7, 128.47 APE8-rot-in 314.42 APE67-dihe-out -53.73, -32.82 -80.68, 66.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.69 None None None XRAY 1.98 0.172 0.214 A 279 243 26 0 0 15 [[8, 271]] 1.0 2xno Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 5M55A P51955 3 271 445.0 7GG:60301 Type1 Inactive None 999.0 999.0 None -114.19, -135.1 -178.71, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.381 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.78 APE8-rot-out 202.77 APE67-dihe-out -53.34, -31.96 -91.76, 69.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.191 0.249 A 279 232 37 0 0 19 [[8, 271]] 1.0 5m55 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 6SGDA P51955 3 271 445.0 LD5:60304 Type1 Inactive None 999.0 999.0 None -127.67, 170.43 62.02, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.071 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na 999.0, -46.25 APE9-dihe-na -98.23, 161.49 APE8-dihe-in -73.88, 123.98 APE8-rot-in 325.25 APE67-dihe-out -60.94, -25.35 -80.76, 75.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.2 0.234 A 279 240 29 0 0 17 [[8, 271]] 1.0 6sgd Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 6SGHA P51955 3 271 445.0 LCW:60301 Type1 Inactive None 999.0 999.0 None -170.33, 169.0 -77.31, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.147 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -30.5 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.23 0.29 A 279 230 39 0 0 21 [[8, 271]] 1.0 6sgh Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 6SGIA P51955 3 271 445.0 LCB:60301 Type1 Inactive None 999.0 999.0 None -99.2, 164.85 -97.27, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.568 Saltbr-out 12.267 HRD-none 999.0, 112.82 -122.18, -174.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -108.16, -24.32 APE9-dihe-na -78.79, 148.96 APE8-dihe-in -71.64, 136.44 APE8-rot-in 324.51 APE67-dihe-out -63.23, -22.68 -80.23, 81.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.151 None None None XRAY 2.3 0.216 0.266 A 279 244 25 0 0 16 [[8, 271]] 1.0 6sgi Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 6SGKA P51955 3 271 445.0 LCQ:60301 Type1 Inactive None 999.0 999.0 None -109.89, -152.44 174.9, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.514 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnnn APE10-dihe-na -78.19, -29.68 APE9-dihe-na -72.58, 155.55 APE8-dihe-in -95.97, 127.89 APE8-rot-in 324.86 APE67-dihe-out -58.29, -30.48 -74.01, 72.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.197 0.223 A 279 239 30 0 0 16 [[8, 271]] 1.0 6sgk Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 6SK9A P51955 4 271 445.0 F9N:60301 Type1 Inactive None 999.0 999.0 None -95.31, 177.22 48.53, 40.4 -138.88, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.371 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 79.29 APE8-dihe-in -99.35, 119.5 APE8-rot-out 165.62 APE67-dihe-out -52.47, -29.05 -77.36, 72.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.19 0.22 A 279 232 36 0 0 17 [[8, 271]] 1.0 6sk9 Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK2_HUMAN 2JAVA P51955 3 271 445.0 5Z5:61280 Type1 Inactive None 12.445 19.007 None -67.88, 137.1 -47.89, 123.79 -62.34, -34.41 294.47, 133.99 -68.12, -29.67 out-out out 11.812 Saltbr-out 14.791 HRD-none 999.0, 999.0 999.0, 999.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.9 APE8-dihe-out -80.72, -38.69 APE8-rot-out 190.2 APE67-dihe-out 67.83, -49.58 -75.41, -43.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T175A None None XRAY 2.2 0.217 0.277 A 279 245 24 0 0 11 [[8, 271]] 1.0 2jav Homo sapiens NEK_NEK2_HUMAN NEK 3.4e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2

NEK_NEK2 (Serine/threonine-protein kinase Nek2)

Total number of chains: 0
Active chains: 0
Family: NEK
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name