CMGC_MAPK14 (Mitogen-activated protein kinase 14)

Total number of chains: 284
Active chains: 3
Uniprot: MK14_HUMAN
Kinase Domain Residues: 24 - 308
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 80 28.2% 3GC7A
DFGin None 47 16.5% 8X3MA
DFGout BBAminus 46 16.2% 3KQ7A
DFGin BLBminus 36 12.7% 8YD9A
DFGout None 29 10.2% 1WBSA
None None 21 7.4% 8A8MA
DFGinter None 12 4.2% 5WJJA
DFGin BLAminus 10 3.5% AF-Q16539-K1A
DFGin BLAplus 3 1.1% 3HUBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAPK14 AF-Q16539-K1A Q16539 16 316 360.0 No_ligand No_ligand Active DFGin 6.3916 14.553 BLAminus -111.68, 175.06 58.78, 74.94 -79.92, 13.31 286.54, 83.12 -61.54, -26.1 in-in in 9.1356 Saltbr-in 2.6698 HRD-in -80.43, -49.45 64.0, 16.06 in-in-in SNCiii in-in ActLoopNT-in 2.8923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.49, 168.5 APE9-dihe-na 60.0, 147.27 APE8-dihe-in -64.74, 130.52 APE8-rot-in 300.11 APE67-dihe-in -67.86, -22.69 -49.74, -43.79 APE12-dist-in 11.7263 APE11-dist-in 11.2272 APE10-dist-in 6.9834 APE9-dist-in 3.0638 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 25 25 0 [[24, 308]] 1.0 AF-Q16539-K1 CMGC_MAPK14_HUMAN CMGC 3.1e-85 292.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 AF-Q16539-K3A Q16539 16 316 360.0 No_ligand No_ligand Active DFGin 6.7156 14.5403 BLAminus -118.33, 171.9 61.33, 65.97 -74.85, 14.93 288.66, 81.1 -63.87, -20.34 in-in in 9.5923 Saltbr-in 2.7612 HRD-in -74.9, -43.91 63.84, 11.15 in-in-in SNCiii in-in ActLoopNT-in 2.8396 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.65, 171.67 APE9-dihe-na 59.51, 139.05 APE8-dihe-in -53.62, 133.53 APE8-rot-in 286.45 APE67-dihe-in -69.5, -18.44 -46.51, -48.09 APE12-dist-in 11.1248 APE11-dist-in 11.1248 APE10-dist-in 6.4844 APE9-dist-in 3.0684 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 25 25 0 [[24, 308]] 1.0 AF-Q16539-K3 CMGC_MAPK14_HUMAN CMGC 3.1e-85 292.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9CJ2A Q16539 4 352 360.0 No_ligand No_ligand Active DFGin 7.0541 15.2151 BLAminus -116.87, 173.2 53.35, 78.52 -89.8, 42.55 291.12, 76.12 -80.06, -35.53 in-in in 9.5756 Saltbr-in 2.8654 HRD-in -80.13, -53.11 78.23, 5.92 in-in-in SNCiii in-in ActLoopNT-in 3.0164 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.43, -179.16 APE9-dihe-na 56.23, -174.96 APE8-dihe-in -105.36, 149.51 APE8-rot-in 298.78 APE67-dihe-in -73.19, -7.83 -55.54, -51.59 APE12-dist-in 10.9733 APE11-dist-in 11.1141 APE10-dist-in 6.7661 APE9-dist-in 2.9202 None TPO180,PTR182 TPO180,PTR182 XRAY 2.83 0.281 0.308 A 360.0 347.0 2 25 25 0 [[24, 308]] 1.0 9cj2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HVCA Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.001 14.1177 BLAminus -117.3, 162.28 48.45, 62.22 -54.05, -25.26 320.24, 130.58 54.74, 999.0 in-in in 9.2797 Saltbr-in 2.5453 HRD-in -69.38, -51.52 77.78, -17.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -66.04 APE8-rot-out 54.89 APE67-dihe-in -58.13, -29.46 -158.78, -30.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.226 0.267 A 362.0 327.0 21 25 11 14 [[24, 308]] 1.0 3hvc CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WBWA Q16539 4 355 360.0 LI4:1355 Type1 Inactive DFGin 7.5498 16.2674 BLAminus -114.87, 175.82 52.97, 77.06 -65.37, 9.09 283.4, 69.37 71.81, 22.41 in-in in 9.2583 Saltbr-in 2.8087 HRD-in -68.77, -47.28 73.71, -9.85 in-out-out SNCioo out-out ActLoopNT-out 10.725 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.9, 136.82 APE9-dihe-na -61.44, -23.14 APE8-dihe-out -57.7, -19.84 APE8-rot-out 51.58 APE67-dihe-in -57.97, -23.53 -115.99, -22.15 APE12-dist-out 21.5602 APE11-dist-out 23.4018 APE10-dist-out 17.5935 APE9-dist-out 11.6839 None None None XRAY 2.41 0.201 0.273 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbw CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6ZQSA Q16539 4 353 360.0 3FF:400 Type1 Inactive DFGin 7.1312 15.0067 BLAminus -100.05, 172.92 58.72, 89.64 -100.69, 26.63 286.71, 76.86 -66.14, -26.38 out-out out 10.2824 Saltbr-out 3.9201 HRD-in -83.97, -53.39 74.81, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.8547 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.23, 173.02 APE9-dihe-na 73.87, 161.94 APE8-dihe-in -91.46, 139.33 APE8-rot-in 294.96 APE67-dihe-in -66.05, -18.45 -53.95, -45.87 APE12-dist-in 11.599 APE11-dist-in 11.174 APE10-dist-in 6.7713 APE9-dist-in 3.0458 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.178 0.223 A 362.0 350.0 0 25 25 0 [[24, 308]] 1.0 6zqs CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6TCAB Q16539 6 354 360.0 39G:401 Type1.5_Back Inactive DFGin 6.742 15.7684 BLAminus -130.28, -179.18 59.49, 69.66 -85.81, 23.35 282.2, 65.31 -63.84, -34.91 out-out out 11.1131 Saltbr-out 5.6384 HRD-in -66.49, -45.95 70.86, -7.28 out-in-out SNCoio in-out ActLoopNT-in 3.3302 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.48, -58.05 APE9-dihe-na -75.98, 156.63 APE8-dihe-in -62.39, 131.74 APE8-rot-out 166.29 APE67-dihe-in -54.53, -22.14 -54.99, -53.8 APE12-dist-in 11.7413 APE11-dist-in 12.5434 APE10-dist-in 7.4214 APE9-dist-in 3.2358 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 B 364.0 346.0 3 25 25 0 [[24, 308]] 1.0 6tca CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6TCAD Q16539 4 353 360.0 39G:401 Type1.5_Back Inactive DFGin 6.9547 16.1724 BLAminus -125.48, -175.55 59.52, 68.68 -88.14, 27.72 279.96, 77.65 -57.15, -38.97 out-out out 11.166 Saltbr-out 5.693 HRD-in -62.99, -39.55 70.16, -10.43 out-in-out SNCoio in-out ActLoopNT-in 3.0863 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioi APE10-dihe-na -80.04, 153.64 APE9-dihe-na -82.75, -163.37 APE8-dihe-out 65.6, 54.59 APE8-rot-out 83.62 APE67-dihe-in -61.09, -43.8 -46.44, -54.01 APE12-dist-in 12.1179 APE11-dist-in 12.6956 APE10-dist-out 8.7934 APE9-dist-in 4.9173 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 D 364.0 346.0 4 25 25 0 [[24, 308]] 1.0 6tca CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6TCAF Q16539 6 353 360.0 39G:401 Type1.5_Back Inactive DFGin 7.0199 15.9029 BLAminus -157.27, -163.9 58.12, 65.17 -92.38, 59.15 303.67, 0.4 -62.65, -37.82 out-out out 11.3868 Saltbr-out 6.4445 HRD-in -64.79, -43.64 63.61, 6.87 out-in-out SNCoio in-out ActLoopNT-in 2.9818 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -128.13, 177.99 APE9-dihe-na 63.26, 84.34 APE8-dihe-in -33.91, 143.61 APE8-rot-out 68.05 APE67-dihe-in -60.74, -43.9 -59.71, -43.06 APE12-dist-in 11.9319 APE11-dist-in 12.4616 APE10-dist-out 8.0332 APE9-dist-in 3.5995 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 F 364.0 344.0 4 25 25 0 [[24, 308]] 1.0 6tca CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6TCAH Q16539 4 353 360.0 39G:401 Type1.5_Back Inactive DFGin 6.6365 16.1566 BLAminus -143.98, 175.6 56.15, 68.06 -81.43, 14.58 273.4, 106.74 -60.09, -44.0 out-out out 11.2433 Saltbr-out 4.8497 HRD-in -91.38, -34.82 53.07, 10.54 out-in-in SNCoii in-in ActLoopNT-in 2.6108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.85, -82.87 APE9-dihe-na -72.81, 167.47 APE8-dihe-in -65.51, 140.73 APE8-rot-in 325.69 APE67-dihe-in -64.02, -39.56 -54.41, -51.98 APE12-dist-in 11.5292 APE11-dist-in 11.9925 APE10-dist-in 7.8442 APE9-dist-in 3.4196 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 H 364.0 346.0 4 25 25 0 [[24, 308]] 1.0 6tca CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HUBA Q16539 4 352 360.0 469:361 Type1 Inactive DFGin 4.731 13.4735 BLAplus -114.99, 158.58 74.87, 37.1 -91.08, 94.47 28.89, 89.39 148.41, 999.0 in-in in 9.1217 Saltbr-in 2.8735 HRD-in -63.44, -55.08 80.73, -16.58 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -160.94 APE8-rot-out 184.21 APE67-dihe-in -64.8, -19.64 -104.95, -3.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.25 0.217 0.292 A 360.0 335.0 14 25 11 14 [[24, 308]] 1.0 3hub CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3UVPA Q16539 5 352 360.0 048:361 Type1 Inactive DFGin 5.9029 14.0354 BLAplus -128.96, 167.37 69.29, 45.08 -117.27, 80.33 39.32, 88.72 -113.85, -175.51 in-in in 8.6759 Saltbr-in 2.5562 HRD-in -71.0, -49.77 82.36, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 132.67 APE9-dihe-na -130.56, 135.77 APE8-dihe-out -78.62, -6.53 APE8-rot-out 68.87 APE67-dihe-in -66.48, -13.93 -109.38, 1.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.916 APE9-dist-out 13.1826 None None None XRAY 2.4 0.216 0.297 A 360.0 334.0 14 25 14 11 [[24, 308]] 1.0 3uvp CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3UVQA Q16539 5 353 360.0 FS8:361 Type1 Inactive DFGin 4.9432 14.1155 BLAplus -108.35, 165.19 59.32, 36.84 -101.79, 71.96 57.48, 77.44 163.27, 167.24 in-in in 8.943 Saltbr-in 2.833 HRD-in -75.44, -58.21 84.54, -18.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -176.56 APE8-rot-out 41.57 APE67-dihe-in -62.66, -23.03 -75.22, -6.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.239 0.318 A 360.0 333.0 16 25 12 13 [[24, 308]] 1.0 3uvq CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5N68A Q16539 4 351 360.0 8OK:401 Allosteric Inactive DFGin 7.1871 16.0011 BLBminus -132.8, -169.79 49.09, 62.16 -56.84, 161.9 297.29, 60.42 -75.69, 999.0 in-in in 9.4007 Saltbr-in 2.8176 HRD-in -69.7, -49.52 79.9, -19.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -54.59 APE8-rot-out 175.1 APE67-dihe-in -63.96, -22.6 -56.46, -20.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.199 0.22 A 360.0 328.0 20 25 11 14 [[24, 308]] 1.0 5n68 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 8YD9A Q16539 4 353 360.0 6GI:401 Allosteric Inactive DFGin 7.5603 16.6454 BLBminus -120.34, 169.61 41.78, 72.62 -60.87, 160.51 290.17, 61.87 -80.92, 82.21 in-in in 9.6172 Saltbr-in 2.8449 HRD-in -66.62, -54.49 86.21, -14.87 in-out-out SNCioo out-out ActLoopNT-out 10.7168 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.56, 132.3 APE9-dihe-na -62.85, -15.25 APE8-dihe-out -63.39, -16.12 APE8-rot-out 50.03 APE67-dihe-in -65.78, -19.25 -116.75, -17.41 APE12-dist-out 21.9239 APE11-dist-out 24.1116 APE10-dist-out 18.3983 APE9-dist-out 11.85 None None None XRAY 1.66 0.163 0.205 A 360.0 350.0 0 25 25 0 [[24, 308]] 1.0 8yd9 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2Y8OA Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.7433 16.8229 BLBminus -138.36, -179.55 53.29, 59.75 -55.87, 145.37 283.56, 66.78 -67.71, 123.75 in-in in 9.7185 Saltbr-in 3.0063 HRD-in -66.11, -52.04 86.07, -23.03 in-out-out SNCioo out-out ActLoopNT-out 9.8385 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -177.95 APE8-rot-out 47.02 APE67-dihe-in -62.72, -18.98 -116.55, -3.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C162S None None XRAY 1.95 0.177 0.209 A 362.0 339.0 11 25 14 11 [[24, 308]] 1.0 2y8o CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1R3CA Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.502 16.5774 BLBminus -145.02, -172.91 51.63, 52.82 -55.3, 152.63 287.37, 64.83 -71.8, 106.36 in-in in 9.3885 Saltbr-in 2.6823 HRD-in -65.48, -52.69 76.28, -10.64 in-out-out SNCioo out-out ActLoopNT-out 10.5627 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -130.09, 134.84 APE9-dihe-na -62.67, -23.44 APE8-dihe-out -61.18, -13.14 APE8-rot-out 53.68 APE67-dihe-in -57.73, -23.21 -120.31, -19.81 APE12-dist-out 22.0389 APE11-dist-out 24.168 APE10-dist-out 18.3976 APE9-dist-out 11.6927 C162S None None XRAY 2.0 0.2 0.224 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 1r3c CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2LGCA Q16539 2 354 360.0 No_ligand No_ligand Inactive DFGin 6.8933 15.6774 BLBminus -112.9, 158.36 55.82, 75.36 -56.13, 146.45 306.25, 129.33 -79.0, 52.75 out-out out 10.0931 Saltbr-out 3.882 HRD-in -73.57, -54.1 82.77, -21.72 out-out-out SNCooo out-out ActLoopNT-out 11.1366 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na 59.79, 174.94 APE9-dihe-na -82.63, 57.56 APE8-dihe-out -108.66, -41.01 APE8-rot-out 69.43 APE67-dihe-in -63.44, -21.86 -92.32, -21.25 APE12-dist-out 22.0644 APE11-dist-out 19.1938 APE10-dist-out 16.9452 APE9-dist-out 12.3613 None None None NMR 999.0 999.0 999.0 A 359.0 353.0 0 25 25 0 [[24, 308]] 1.0 2lgc CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5ETAA Q16539 4 354 360.0 No_ligand No_ligand Inactive DFGin 7.1569 16.0318 BLBminus -141.39, 172.08 57.41, 75.46 -79.2, 159.99 305.15, 4.16 -79.17, 999.0 out-out out 10.0606 Saltbr-out 3.8381 HRD-out -71.28, 117.84 -99.9, 129.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.3, -10.62 999.0, -28.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.223 0.29 A 360.0 336.0 15 25 10 15 [[24, 308]] 1.0 5eta CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5ETAB Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 6.6612 15.6087 BLBminus -141.34, 173.45 57.65, 76.86 -79.32, 160.66 304.14, 21.59 -78.74, 999.0 out-out out 10.145 Saltbr-out 4.1091 HRD-in -64.54, -46.9 72.72, -11.57 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.94, -15.91 999.0, 18.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.223 0.29 B 360.0 335.0 15 25 10 15 [[24, 308]] 1.0 5eta CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9CJ2B Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 7.2006 16.0665 BLBminus -117.17, 175.34 53.95, 75.39 -89.71, 147.73 291.67, 75.51 152.14, -34.2 out-out out 10.6863 Saltbr-out 3.8317 HRD-in -80.84, -55.81 75.66, 9.43 out-in-in SNCoii in-in ActLoopNT-in 2.7385 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.3, -40.08 APE9-dihe-na -88.33, -173.72 APE8-dihe-in -105.0, 147.42 APE8-rot-in 299.07 APE67-dihe-inflip 57.56, -2.13 -67.17, 153.5 APE12-dist-in 11.4503 APE11-dist-in 11.6012 APE10-dist-in 6.8955 APE9-dist-in 3.1705 None TPO180,PTR182 TPO180,PTR182 XRAY 2.83 0.281 0.308 B 360.0 337.0 10 25 24 1 [[24, 308]] 1.0 9cj2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1R39A Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGin 6.2424 15.6212 BLBminus -100.63, 170.62 -0.96, 98.11 -65.4, 170.41 322.57, 74.0 -64.2, 131.69 in-out in 9.8215 Saltbr-out 3.7547 HRD-in -69.24, -48.98 82.5, -25.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.33, 137.12 APE9-dihe-na -61.11, -31.18 APE8-dihe-out -59.75, -12.63 APE8-rot-out 50.53 APE67-dihe-in -57.43, -19.19 -117.05, -22.73 APE12-dist-out 21.5157 APE11-dist-out 23.8232 APE10-dist-out 18.0787 APE9-dist-out 12.369 None None None XRAY 2.3 0.209 0.249 A 366.0 345.0 3 25 22 3 [[24, 308]] 1.0 1r39 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2OKRA Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.5536 16.5668 BLBminus -134.78, -177.84 43.57, 67.63 -61.93, 143.9 285.97, 54.99 -63.82, 118.09 in-in in 9.4628 Saltbr-in 3.0481 HRD-in -61.63, -67.88 95.04, -16.23 in-out-out SNCioo out-out ActLoopNT-out 9.4849 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.46 APE8-dihe-out -50.88, -50.92 APE8-rot-none 999.0 APE67-dihe-in -63.55, -15.29 -67.15, -13.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.235 None None None XRAY 2.0 0.238 0.272 A 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 2okr CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2OKRD Q16539 5 355 360.0 No_ligand No_ligand Inactive DFGin 7.5464 16.5218 BLBminus -136.02, 175.66 52.49, 66.48 -59.93, 143.57 284.61, 60.28 -61.55, 109.72 in-in in 9.4345 Saltbr-in 2.954 HRD-in -66.04, -52.0 79.74, -16.59 in-out-none SNCion out-none ActLoopNT-out 9.3877 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.39, -17.24 999.0, -2.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.238 0.272 D 366.0 339.0 12 25 13 12 [[24, 308]] 1.0 2okr CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2ONLA Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.2877 16.1056 BLBminus -139.8, -177.93 43.34, 77.4 -75.22, 146.44 290.54, 41.49 -62.95, 116.48 in-in in 9.4516 Saltbr-in 2.6513 HRD-in -52.0, -56.17 74.39, -2.78 in-out-none SNCion out-none ActLoopNT-out 9.1471 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 49.36 APE8-rot-none 999.0 APE67-dihe-in -86.46, -33.32 -110.87, 9.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 4.0 0.315 0.331 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 2onl CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2ONLB Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.3212 16.1634 BLBminus -141.81, -179.23 45.19, 76.7 -75.31, 145.49 288.03, 42.26 -62.52, 115.05 in-in in 9.4911 Saltbr-in 2.8294 HRD-in -52.05, -57.26 76.3, -1.57 in-out-out SNCioo out-out ActLoopNT-out 9.1161 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.14 APE8-dihe-out -128.48, 30.34 APE8-rot-none 999.0 APE67-dihe-in -39.69, -33.92 -99.79, -26.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1744 None None None XRAY 4.0 0.315 0.331 B 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 2onl CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5ETFA Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.0134 16.2546 BLBminus -113.01, 169.42 60.38, 71.26 -66.88, 139.87 292.28, 86.16 -72.96, 138.11 out-none out 10.2865 Saltbr-none 999.0 HRD-in -67.23, -46.39 78.26, -18.36 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -17.92 APE8-dihe-out -72.2, -34.2 APE8-rot-out 55.6 APE67-dihe-in -63.87, -20.91 -91.79, -15.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2852 None None None XRAY 2.4 0.166 0.231 A 360.0 338.0 12 25 13 12 [[24, 308]] 1.0 5etf CMGC_MAPK14_HUMAN CMGC 5.9e-84 287.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1BMKA Q16539 4 354 360.0 SB5:800 Type1 Inactive DFGin 7.1217 16.5291 BLBminus -137.22, -169.66 56.32, 44.88 -45.24, 133.86 286.34, 72.89 -52.23, -75.66 in-out in 9.7619 Saltbr-out 3.7479 HRD-in -63.64, -53.75 77.86, -16.8 out-out-out SNCooo out-out ActLoopNT-out 9.514 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -119.53, 132.15 APE9-dihe-na -60.85, -24.23 APE8-dihe-out -62.44, -19.14 APE8-rot-out 62.45 APE67-dihe-in -60.11, -20.13 -109.63, -21.41 APE12-dist-out 22.2759 APE11-dist-out 24.3467 APE10-dist-out 18.5571 APE9-dist-out 11.863 None None None XRAY 2.4 0.189 0.245 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1bmk CMGC_MAPK14_HUMAN CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MW1A Q16539 4 352 360.0 MIH:1 Type1 Inactive DFGin 7.0914 15.6534 BLBminus -132.66, 167.77 44.25, 77.33 -67.05, 164.83 301.32, 86.64 -78.77, 69.58 in-in in 9.2873 Saltbr-in 2.718 HRD-in -90.51, -42.46 74.96, -39.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.83, 140.74 APE9-dihe-na -74.87, -7.04 APE8-dihe-out -61.38, -14.99 APE8-rot-out 171.94 APE67-dihe-in -82.2, -6.08 -133.4, 0.84 APE12-dist-out 22.1585 APE11-dist-out 24.3615 APE10-dist-out 18.6441 APE9-dist-out 11.9023 None None None XRAY 2.8 0.259 0.339 A 359.0 342.0 7 25 23 2 [[24, 308]] 1.0 3mw1 CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1DI9A Q16539 4 351 360.0 MSQ:500 Type1 Inactive DFGin 7.7564 16.5688 BLBminus -140.41, -172.23 47.23, 67.42 -68.51, 162.42 284.54, 55.87 -75.89, 110.12 in-in in 9.0586 Saltbr-in 3.1062 HRD-in -65.18, -38.96 42.63, 26.65 in-out-out SNCioo out-out ActLoopNT-out 10.862 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.87, 134.68 APE9-dihe-na -58.83, -9.68 APE8-dihe-out -74.85, -6.92 APE8-rot-out 66.23 APE67-dihe-in -59.93, -24.34 -127.05, -19.2 APE12-dist-out 21.9225 APE11-dist-out 23.9446 APE10-dist-out 18.2443 APE9-dist-out 11.9784 None None None XRAY 2.6 0.209 0.253 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 1di9 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1W7HA Q16539 4 355 360.0 3IP:1355 Type1 Inactive DFGin 7.7961 17.0549 BLBminus -126.97, 174.81 45.3, 68.52 -59.92, 159.01 290.19, 61.39 -65.46, 100.81 in-in in 9.5922 Saltbr-in 2.9754 HRD-in -66.31, -55.3 89.68, -16.31 in-out-out SNCioo out-out ActLoopNT-out 10.7805 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -130.74, 137.94 APE9-dihe-na -62.48, -23.82 APE8-dihe-out -56.07, -23.6 APE8-rot-out 56.54 APE67-dihe-in -60.27, -19.52 -110.55, -22.95 APE12-dist-out 22.3591 APE11-dist-out 24.4048 APE10-dist-out 18.6833 APE9-dist-out 11.9853 None None None XRAY 2.214 0.183 0.233 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w7h CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1W84A Q16539 4 355 360.0 L12:1356 Type1 Inactive DFGin 7.6501 16.5415 BLBminus -120.74, 171.92 61.53, 62.34 -66.83, 153.55 283.45, 69.16 -66.75, 86.26 in-in in 9.6038 Saltbr-in 2.6929 HRD-in -64.89, -52.25 82.48, -12.16 in-out-out SNCioo out-out ActLoopNT-out 10.7871 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.19, 133.54 APE9-dihe-na -63.3, -20.54 APE8-dihe-out -62.12, -18.89 APE8-rot-out 50.08 APE67-dihe-in -62.02, -22.2 -113.11, -19.49 APE12-dist-out 22.3273 APE11-dist-out 24.4704 APE10-dist-out 18.6246 APE9-dist-out 11.8277 None None None XRAY 2.2 0.182 0.238 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w84 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2ZB0A Q16539 4 352 360.0 GK3:361 Type1 Inactive DFGin 7.7654 16.2288 BLBminus -137.48, -175.21 49.81, 58.54 -56.14, 139.15 284.33, 72.04 -63.78, 112.08 in-in in 9.1667 Saltbr-in 2.6879 HRD-in -68.02, -49.82 75.51, -11.64 in-out-out SNCioo out-out ActLoopNT-out 10.9202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -141.37, 135.74 APE9-dihe-na -61.38, -19.35 APE8-dihe-out -65.18, -21.78 APE8-rot-out 47.27 APE67-dihe-in -62.12, -22.94 -113.09, -19.43 APE12-dist-out 21.9628 APE11-dist-out 24.0837 APE10-dist-out 18.4019 APE9-dist-out 11.6658 None None None XRAY 2.1 0.174 0.212 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 2zb0 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1M7QA Q16539 4 351 360.0 DQO:501 Type1 Inactive DFGin 8.0398 16.5774 BLBminus -116.55, -179.82 62.9, 86.7 -124.28, 146.05 278.55, 112.99 54.76, 19.36 in-in in 9.5873 Saltbr-in 3.3089 HRD-in -72.49, -44.98 75.68, -16.58 in-out-out SNCioo out-out ActLoopNT-out 11.0563 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.68, 132.65 APE9-dihe-na -56.74, -10.63 APE8-dihe-out -77.85, -7.16 APE8-rot-out 52.42 APE67-dihe-in -65.93, -19.72 -128.13, -13.55 APE12-dist-out 21.5861 APE11-dist-out 23.3947 APE10-dist-out 17.5245 APE9-dist-out 12.17 None None None XRAY 2.4 0.217 0.254 A 366.0 348.0 0 25 25 0 [[24, 308]] 1.0 1m7q CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1OUKA Q16539 4 351 360.0 084:501 Type1 Inactive DFGin 8.0216 16.4531 BLBminus -120.29, 176.37 71.71, 79.23 -115.84, 130.78 281.72, 116.29 65.14, 27.27 in-in in 9.5643 Saltbr-in 3.1687 HRD-in -64.07, -50.96 81.29, -14.69 in-out-out SNCioo out-out ActLoopNT-out 11.5974 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -120.43, 138.52 APE9-dihe-na -60.72, -20.24 APE8-dihe-out -66.76, -17.57 APE8-rot-out 43.24 APE67-dihe-in -61.59, -23.16 -114.27, -15.3 APE12-dist-out 21.6434 APE11-dist-out 23.4239 APE10-dist-out 17.5306 APE9-dist-out 12.4759 None None None XRAY 2.5 0.217 0.264 A 366.0 348.0 0 25 25 0 [[24, 308]] 1.0 1ouk CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1OUYA Q16539 4 353 360.0 094:501 Type1 Inactive DFGin 8.0014 16.4672 BLBminus -127.01, 172.02 70.13, 95.72 -131.26, 146.15 281.74, 107.1 57.3, 32.52 in-in in 9.4127 Saltbr-in 2.9854 HRD-in -74.27, -49.28 73.36, -15.55 in-out-out SNCioo out-out ActLoopNT-out 11.3049 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -118.35, 133.85 APE9-dihe-na -63.2, -4.09 APE8-dihe-out -79.22, -6.55 APE8-rot-out 71.77 APE67-dihe-in -52.87, -23.93 -119.38, -25.62 APE12-dist-out 21.4677 APE11-dist-out 23.3589 APE10-dist-out 17.4767 APE9-dist-out 12.2091 None None None XRAY 2.5 0.226 0.256 A 366.0 350.0 0 25 25 0 [[24, 308]] 1.0 1ouy CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1YQJA Q16539 2 352 360.0 6NP:60362 Type1 Inactive DFGin 7.3287 16.1083 BLBminus -138.77, -163.86 37.6, 61.55 -60.11, 143.61 296.61, 65.49 -86.45, 47.76 in-out in 9.888 Saltbr-out 4.3044 HRD-in -61.71, -56.56 82.56, -22.38 out-out-out SNCooo out-out ActLoopNT-out 10.1615 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -129.58, 136.01 APE9-dihe-na -64.08, -20.19 APE8-dihe-out -62.87, -14.41 APE8-rot-out 51.35 APE67-dihe-in -61.66, -22.34 -117.68, -17.48 APE12-dist-out 22.1904 APE11-dist-out 24.3938 APE10-dist-out 18.7333 APE9-dist-out 11.9298 None None None XRAY 2.0 0.205 0.257 A 366.0 351.0 0 25 25 0 [[24, 308]] 1.0 1yqj CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ZYAA Q16539 1 353 360.0 2A8:60400 Type1 Inactive DFGin 6.9161 15.6674 BLBminus -120.67, 153.65 52.28, 73.55 -57.04, 142.46 306.58, 150.01 -77.06, 179.75 out-in out 10.0107 Saltbr-in 3.0905 HRD-in -69.11, -55.81 83.28, -17.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 14.11 APE8-dihe-out -74.11, -29.92 APE8-rot-out 58.3 APE67-dihe-in -66.06, -20.49 -108.78, -11.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3841 None None None XRAY 1.9 0.172 0.209 A 366.0 341.0 12 25 13 12 [[24, 308]] 1.0 3zya CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1OZ1A Q16539 5 352 360.0 FPH:500 Type1 Inactive DFGin 8.2109 17.0634 BLBminus -114.16, 172.08 85.44, 88.77 -133.96, 133.95 284.79, 95.76 65.21, 19.9 in-in in 9.511 Saltbr-in 2.5307 HRD-in -66.15, -54.29 77.91, -14.08 in-out-out SNCioo out-out ActLoopNT-out 11.5356 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.9, 134.09 APE9-dihe-na -64.8, -17.47 APE8-dihe-out -61.1, -18.06 APE8-rot-out 58.91 APE67-dihe-in -61.43, -23.68 -115.97, -17.25 APE12-dist-out 21.583 APE11-dist-out 23.4406 APE10-dist-out 17.5936 APE9-dist-out 11.826 None None None XRAY 2.1 0.204 0.251 A 372.0 344.0 4 25 25 0 [[24, 308]] 1.0 1oz1 CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FLQA Q16539 4 352 360.0 891:361 Type1 Inactive DFGin 8.3047 16.7597 BLBminus -114.5, 174.13 79.93, 71.12 -113.07, 140.32 283.22, 109.18 72.54, 15.24 in-in in 9.1526 Saltbr-in 2.5388 HRD-in -68.62, -54.92 81.05, -20.42 in-out-out SNCioo out-out ActLoopNT-out 10.6966 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.83, 134.4 APE9-dihe-na -61.43, -21.08 APE8-dihe-out -63.2, -18.72 APE8-rot-out 68.98 APE67-dihe-in -64.73, -17.91 -116.21, -18.71 APE12-dist-out 21.2413 APE11-dist-out 23.0908 APE10-dist-out 17.2616 APE9-dist-out 11.6901 None None None XRAY 1.9 0.235 0.275 A 372.0 345.0 4 25 25 0 [[24, 308]] 1.0 3flq CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FMJA Q16539 4 352 360.0 FMJ:361 Type1 Inactive DFGin 7.6822 16.6353 BLBminus -119.99, 177.68 52.9, 58.7 -54.87, 149.87 287.37, 61.96 -90.97, 999.0 in-in in 9.3617 Saltbr-in 2.5771 HRD-in -67.72, -48.76 77.48, -19.13 in-out-out SNCioo out-out ActLoopNT-out 10.8603 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -135.4, 132.7 APE9-dihe-na -58.69, -22.38 APE8-dihe-out -61.41, -17.71 APE8-rot-out 63.25 APE67-dihe-in -62.27, -20.19 -116.89, -20.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7599 None None None XRAY 2.0 0.217 0.268 A 372.0 344.0 5 25 23 2 [[24, 308]] 1.0 3fmj CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FSFA Q16539 5 352 360.0 FSS:450 Type1 Inactive DFGin 7.5209 16.559 BLBminus -126.93, 179.76 39.65, 72.67 -65.36, 151.92 292.97, 66.55 -17.25, 999.0 in-in in 9.4333 Saltbr-in 2.6944 HRD-in -59.58, -53.1 75.06, -9.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.46, 135.81 APE9-dihe-na -64.88, -14.68 APE8-dihe-out -66.01, -18.5 APE8-rot-out 44.13 APE67-dihe-in -59.72, -21.22 -117.36, -17.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9281 None None None XRAY 2.1 0.225 0.259 A 372.0 340.0 8 25 22 3 [[24, 308]] 1.0 3fsf CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1A9UA Q16539 4 354 360.0 SB2:800 Type1 Inactive DFGin 7.5045 16.7941 BLBminus -114.41, -166.13 12.94, 87.82 -68.23, 136.53 280.46, 77.71 -65.57, -40.4 in-in in 9.698 Saltbr-in 2.7381 HRD-in -62.88, -52.08 77.6, -12.91 in-out-out SNCioo out-out ActLoopNT-out 9.8282 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.45, 130.72 APE9-dihe-na -61.08, -19.54 APE8-dihe-out -64.32, -8.61 APE8-rot-out 46.86 APE67-dihe-in -65.16, -15.35 -123.62, -15.84 APE12-dist-out 22.8835 APE11-dist-out 24.7998 APE10-dist-out 19.2982 APE9-dist-out 11.7286 None None None XRAY 2.5 0.182 0.24 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1a9u CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1BL6A Q16539 4 354 360.0 SB6:800 Type1 Inactive DFGin 7.4564 16.538 BLBminus -145.17, -172.57 51.82, 52.45 -53.54, 141.28 284.57, 66.27 -55.43, -57.86 in-in in 9.5893 Saltbr-in 2.8675 HRD-in -51.96, -53.43 79.64, -20.23 in-out-out SNCioo out-out ActLoopNT-out 9.9548 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -123.42, 132.07 APE9-dihe-na -58.07, -30.56 APE8-dihe-out -55.1, -34.56 APE8-rot-out 71.27 APE67-dihe-in -61.14, -14.61 -91.38, -21.67 APE12-dist-out 22.7877 APE11-dist-out 24.7944 APE10-dist-out 19.0587 APE9-dist-out 11.945 None None None XRAY 2.5 0.185 0.251 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1bl6 CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1BL7A Q16539 4 354 360.0 SB4:800 Type1 Inactive DFGin 7.9115 16.7904 BLBminus -135.76, -164.94 45.19, 53.1 -57.31, 172.61 275.72, 65.22 -88.08, -57.25 in-in in 9.2873 Saltbr-in 2.8625 HRD-in -59.74, -47.17 76.3, -19.18 in-out-out SNCioo out-out ActLoopNT-out 10.14 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -120.45, 132.04 APE9-dihe-na -67.19, -14.66 APE8-dihe-out -66.31, -16.07 APE8-rot-out 63.68 APE67-dihe-in -59.41, -12.41 -116.23, -18.86 APE12-dist-out 23.8221 APE11-dist-out 25.9511 APE10-dist-out 20.1481 APE9-dist-out 11.8911 None None None XRAY 2.5 0.193 0.265 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1bl7 CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MPAA Q16539 5 352 360.0 SB2:361 Type1 Inactive DFGin 7.2743 15.3554 BLBminus -133.49, -165.87 57.46, 46.09 -54.73, 150.67 290.61, 74.17 -42.79, 999.0 in-in in 9.1984 Saltbr-in 2.6173 HRD-in -72.56, -50.67 81.89, -14.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 167.3 APE8-rot-in 334.53 APE67-dihe-in -58.8, -27.47 -62.95, -13.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D168G None None XRAY 2.1 0.235 0.289 A 360.0 331.0 17 25 11 14 [[24, 308]] 1.0 3mpa CMGC_MAPK14_HUMAN CMGC 2.7e-83 285.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2ZB1A Q16539 4 352 360.0 GK4:361 Type1.5_Back Inactive DFGin 7.3325 15.632 BLBminus -130.35, 170.65 45.65, 69.72 -60.48, 135.77 297.96, 80.44 -60.1, 109.16 in-in in 9.1642 Saltbr-in 2.6702 HRD-in -61.25, -52.64 82.49, -17.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -142.2, 137.03 APE9-dihe-na -61.77, -22.73 APE8-dihe-out -57.45, -25.09 APE8-rot-out 52.04 APE67-dihe-in -64.0, -18.53 -113.02, -16.57 APE12-dist-out 21.888 APE11-dist-out 23.8985 APE10-dist-out 18.2966 APE9-dist-out 11.7672 None None None XRAY 2.5 0.172 0.239 A 360.0 345.0 4 25 23 2 [[24, 308]] 1.0 2zb1 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5XYXA Q16539 4 353 360.0 FTZ:401 Type1.5_Back Inactive DFGin 8.2729 16.6397 BLBminus -116.2, 173.45 58.06, 87.28 -116.16, 154.24 295.44, 84.66 106.17, 999.0 in-in in 9.2714 Saltbr-in 3.1201 HRD-in -67.68, -47.02 80.87, -18.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -138.98, 135.51 APE9-dihe-na -62.25, -22.13 APE8-dihe-out -61.23, -15.58 APE8-rot-out 46.35 APE67-dihe-in -54.77, -26.55 -120.61, -19.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7398 None None None XRAY 2.61 0.218 0.26 A 380.0 337.0 13 25 22 3 [[24, 308]] 1.0 5xyx CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5XYYA Q16539 4 352 360.0 P0F:401 Type1.5_Back Inactive DFGin 8.1438 16.2502 BLBminus -111.25, 174.05 61.59, 81.71 -109.03, 145.8 286.82, 89.51 69.26, 21.62 in-in in 8.942 Saltbr-in 2.6487 HRD-in -68.14, -52.86 82.9, -10.64 in-out-out SNCioo out-out ActLoopNT-out 11.4762 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 131.59 APE9-dihe-na -62.4, -17.36 APE8-dihe-out -62.41, -19.09 APE8-rot-out 53.75 APE67-dihe-in -64.55, -20.22 -114.48, -18.89 APE12-dist-out 21.1385 APE11-dist-out 22.895 APE10-dist-out 17.0927 APE9-dist-out 11.7589 None None None XRAY 1.7 0.18 0.201 A 380.0 343.0 6 25 25 0 [[24, 308]] 1.0 5xyy CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3NEWA Q16539 5 352 360.0 3NE:361 Allosteric Inactive DFGin 5.3779 13.1071 BLBplus -114.35, 171.8 67.6, 14.1 -53.7, 162.04 18.33, 63.1 61.74, -33.29 in-in in 9.5103 Saltbr-in 3.0638 HRD-in -60.9, -56.32 86.26, -12.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -44.22 APE8-rot-out 178.97 APE67-dihe-in -72.83, -20.41 -64.21, -12.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C162S None None XRAY 2.51 0.219 0.306 A 366.0 334.0 14 25 13 12 [[24, 308]] 1.0 3new CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH2A Q16539 4 354 360.0 IRG:401,0OK:402 Allosteric,Type1 Inactive DFGin 5.0488 13.9493 BLBplus -117.8, 162.51 72.3, 21.2 -57.69, 163.34 31.01, 95.16 92.75, 999.0 in-in in 9.39 Saltbr-in 2.9127 HRD-in -68.61, -52.99 79.87, -17.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 104.22 APE9-dihe-na -64.21, 119.38 APE8-dihe-out -37.73, -46.13 APE8-rot-in 267.35 APE67-dihe-in -65.75, -23.42 -54.51, -28.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4245 None None None XRAY 2.0 0.226 0.274 A 360.0 337.0 14 25 13 12 [[24, 308]] 1.0 4eh2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MH2A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 5.1833 14.4282 BLBplus -108.45, 150.31 80.55, 9.3 -51.09, 147.78 31.6, 88.92 52.72, 999.0 in-out in 9.4616 Saltbr-out 4.1349 HRD-in -87.39, -52.66 84.79, -12.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.3 APE8-rot-in 266.2 APE67-dihe-in -62.25, -28.76 -55.01, -18.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169Y None None XRAY 2.3 0.247 0.318 A 360.0 330.0 18 25 11 14 [[24, 308]] 1.0 3mh2 CMGC_MAPK14_HUMAN CMGC 3.3e-84 288.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5ETIA Q16539 1 352 360.0 No_ligand No_ligand Inactive DFGin 5.1472 15.4196 BLBplus -119.94, 157.71 69.48, 37.44 -94.83, 139.77 47.07, 94.27 84.3, 5.93 out-none out 10.4335 Saltbr-none 999.0 HRD-in -63.44, -44.0 71.3, -9.39 none-out-out SNCnoo out-out ActLoopNT-out 9.8512 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -125.74, 141.21 APE9-dihe-na -73.47, -31.47 APE8-dihe-out -54.4, -47.64 APE8-rot-out 66.16 APE67-dihe-in -68.53, -25.27 -76.41, -12.45 APE12-dist-out 22.6357 APE11-dist-out 24.4655 APE10-dist-out 18.731 APE9-dist-out 12.2405 None None None XRAY 2.8 0.178 0.225 A 366.0 352.0 0 25 25 0 [[24, 308]] 1.0 5eti CMGC_MAPK14_HUMAN CMGC 6.2e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FI4A Q16539 4 352 360.0 FI4:361 Type1 Inactive DFGin 4.8677 13.6797 BLBplus -116.8, 163.07 65.52, 26.76 -74.81, 149.05 43.11, 82.7 76.87, 6.14 in-in in 9.1105 Saltbr-in 2.6886 HRD-in -60.69, -54.78 85.32, -23.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.35, 135.44 APE9-dihe-na -63.33, -14.63 APE8-dihe-out -67.74, -19.61 APE8-rot-out 60.23 APE67-dihe-in -67.68, -20.67 -113.25, -13.01 APE12-dist-out 22.0872 APE11-dist-out 24.1413 APE10-dist-out 18.5028 APE9-dist-out 12.422 R57K None None XRAY 2.2 0.212 0.238 A 372.0 339.0 10 25 22 3 [[24, 308]] 1.0 3fi4 CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FKOA Q16539 5 352 360.0 FKO:361 Type1 Inactive DFGin 4.6607 13.622 BLBplus -111.44, 157.26 69.44, 28.26 -72.66, 144.44 41.0, 85.24 70.05, 9.98 in-in in 9.1244 Saltbr-in 2.7159 HRD-in -66.96, -53.75 82.74, -20.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.91, 131.16 APE9-dihe-na -61.2, -20.43 APE8-dihe-out -61.86, -23.05 APE8-rot-out 54.03 APE67-dihe-in -63.55, -20.16 -111.23, -16.8 APE12-dist-out 22.0249 APE11-dist-out 24.0109 APE10-dist-out 18.3061 APE9-dist-out 12.0648 R57K None None XRAY 2.0 0.216 0.253 A 372.0 343.0 5 25 22 3 [[24, 308]] 1.0 3fko CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FLNC Q16539 3 352 360.0 3FN:361 Type1 Inactive DFGin 4.8948 13.7477 BLBplus -105.05, 155.94 66.04, 26.04 -70.99, 147.16 45.83, 89.7 76.23, 8.94 in-in in 9.083 Saltbr-in 2.599 HRD-in -67.49, -56.85 81.97, -18.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.61, 135.31 APE9-dihe-na -58.39, -20.63 APE8-dihe-out -64.51, -18.59 APE8-rot-out 57.49 APE67-dihe-in -63.96, -19.95 -115.78, -17.1 APE12-dist-out 22.2434 APE11-dist-out 24.3235 APE10-dist-out 18.6659 APE9-dist-out 12.1947 R57K None None XRAY 1.9 0.211 0.234 C 372.0 343.0 7 25 22 3 [[24, 308]] 1.0 3fln CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6OHDA Q16539 4 352 360.0 MKP:900 Type1 Inactive DFGin 5.0309 13.9055 BLBplus -118.15, 159.21 60.76, 27.76 -70.47, 137.41 41.69, 89.07 66.92, 13.52 in-in in 8.8085 Saltbr-in 2.5408 HRD-in -71.28, -47.06 75.25, -20.9 in-out-out SNCioo out-out ActLoopNT-out 8.1396 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.41 APE8-dihe-in -86.7, 134.65 APE8-rot-out 60.91 APE67-dihe-out -71.49, -18.04 -120.56, 61.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2954 None None None XRAY 2.5 0.213 0.253 A 388.0 330.0 19 25 15 10 [[24, 308]] 1.0 6ohd CMGC_MAPK14_HUMAN CMGC 1e-84 290.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1OVEA Q16539 4 352 360.0 358:401 Type1 Inactive DFGin 4.8066 13.4784 BLBplus -131.9, 174.28 62.22, 23.86 -68.64, 149.36 35.73, 74.72 53.78, 19.07 in-in in 9.1333 Saltbr-in 2.8284 HRD-in -65.96, -52.49 68.25, -0.6 in-out-out SNCioo out-out ActLoopNT-out 9.8879 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.51, 133.59 APE9-dihe-na -56.38, -21.28 APE8-dihe-out -65.12, -19.35 APE8-rot-out 55.52 APE67-dihe-in -65.18, -20.01 -115.17, -13.18 APE12-dist-out 21.7467 APE11-dist-out 23.6988 APE10-dist-out 18.0885 APE9-dist-out 12.27 C162S None None XRAY 2.1 0.195 0.233 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 1ove CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GC7A Q16539 4 352 360.0 B45:361 Type1 Inactive DFGin 6.8914 15.6924 BLBplus -130.29, -178.32 55.87, 56.48 -136.93, 164.81 70.99, 105.71 67.06, 10.11 in-in in 9.1173 Saltbr-in 2.6265 HRD-in -64.07, -56.2 85.52, -15.66 in-out-out SNCioo out-out ActLoopNT-out 10.363 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.45, 132.85 APE9-dihe-na -61.59, -21.21 APE8-dihe-out -58.27, -23.47 APE8-rot-out 53.22 APE67-dihe-in -60.64, -23.63 -113.11, -23.09 APE12-dist-out 22.1523 APE11-dist-out 24.1078 APE10-dist-out 18.3509 APE9-dist-out 11.736 C162S None None XRAY 1.8 0.182 0.208 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3gc7 CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3S3IA Q16539 4 352 360.0 CQ0:1 Type1 Inactive DFGin 5.3256 14.0492 BLBplus -112.59, 160.38 67.13, 22.49 -69.88, 149.56 37.18, 83.84 76.62, -7.09 in-in in 8.7644 Saltbr-in 2.8788 HRD-in -59.53, -53.41 62.43, -11.33 in-out-out SNCioo out-out ActLoopNT-out 9.2592 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.32, 136.07 APE9-dihe-na -59.08, -17.33 APE8-dihe-out -61.43, -18.71 APE8-rot-out 56.9 APE67-dihe-in -67.37, -22.1 -117.88, -13.71 APE12-dist-out 22.2177 APE11-dist-out 24.2199 APE10-dist-out 18.633 APE9-dist-out 11.8861 None None None XRAY 1.8 0.233 0.258 A 349.0 349.0 0 25 25 0 [[24, 308]] 1.0 3s3i CMGC_MAPK14_HUMAN CMGC 5.3e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1ZZLA Q16539 4 354 360.0 TZY:999 Type1 Inactive DFGin 4.733 13.8577 BLBplus -103.73, 163.26 58.07, 31.2 -75.39, 145.77 47.84, 82.21 65.87, 14.85 in-in in 9.2813 Saltbr-in 2.7803 HRD-in -61.64, -58.85 81.18, -19.72 in-out-out SNCioo out-out ActLoopNT-out 10.1664 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -129.62, 134.13 APE9-dihe-na -60.4, -25.87 APE8-dihe-out -57.07, -14.53 APE8-rot-out 52.9 APE67-dihe-in -72.53, -14.8 -116.88, -15.6 APE12-dist-out 22.3703 APE11-dist-out 24.2829 APE10-dist-out 18.6041 APE9-dist-out 12.1132 None None None XRAY 2.0 0.222 0.273 A 351.0 351.0 0 25 25 0 [[24, 308]] 1.0 1zzl CMGC_MAPK14_HUMAN CMGC 5.4e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2YIXA Q16539 4 354 360.0 YIX:1355 Type1 Inactive DFGin 5.0897 14.1287 BLBplus -114.65, 158.99 60.01, 31.87 -79.41, 149.6 45.27, 82.7 60.63, 15.85 in-in in 9.0535 Saltbr-in 2.9319 HRD-in -69.82, -59.44 74.29, -12.91 in-out-out SNCioo out-out ActLoopNT-out 10.057 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -127.34, 129.67 APE9-dihe-na -56.26, -30.86 APE8-dihe-out -60.88, -7.51 APE8-rot-out 59.88 APE67-dihe-in -61.17, -20.41 -120.93, -20.74 APE12-dist-out 22.8344 APE11-dist-out 24.8622 APE10-dist-out 19.0628 APE9-dist-out 11.9454 None None None XRAY 2.3 0.196 0.247 A 351.0 351.0 0 25 25 0 [[24, 308]] 1.0 2yix CMGC_MAPK14_HUMAN CMGC 5.4e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HRBA Q16539 4 352 360.0 I39:1 Type1 Inactive DFGin 4.7404 13.6096 BLBplus -109.68, 159.67 59.92, 25.46 -66.38, 138.28 43.11, 80.53 88.39, -1.65 in-in in 9.0933 Saltbr-in 2.879 HRD-in -67.07, -57.02 74.91, -12.94 in-out-out SNCioo out-out ActLoopNT-out 9.9671 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.19, 133.67 APE9-dihe-na -54.16, -26.74 APE8-dihe-out -60.77, -19.94 APE8-rot-out 56.69 APE67-dihe-in -72.75, -14.91 -115.4, -11.3 APE12-dist-out 21.8484 APE11-dist-out 23.8887 APE10-dist-out 18.2084 APE9-dist-out 12.2655 None None None XRAY 2.2 0.217 0.26 A 359.0 344.0 5 25 25 0 [[24, 308]] 1.0 3hrb CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1ZYJA Q16539 5 352 360.0 BI5:362 Type1 Inactive DFGin 5.1963 13.7975 BLBplus -112.41, 162.76 46.48, 45.87 -86.82, 159.02 43.68, 86.73 65.25, 17.57 in-in in 9.195 Saltbr-in 2.5852 HRD-in -65.9, -54.22 81.4, -15.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 174.12 APE8-rot-in 323.47 APE67-dihe-in -61.35, -24.56 -115.26, 1.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.268 0.267 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 1zyj CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1ZZ2A Q16539 5 352 360.0 B11:362 Type1 Inactive DFGin 5.3394 13.9578 BLBplus -120.85, 149.07 49.89, 48.28 -88.35, 160.53 50.56, 89.91 68.41, 12.43 in-in in 8.7319 Saltbr-in 2.7767 HRD-in -68.3, -55.12 66.46, 3.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.5 APE8-dihe-out -58.95, -37.15 APE8-rot-in 275.96 APE67-dihe-in -50.5, -32.48 -55.76, -39.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5468 None None None XRAY 2.0 0.262 0.29 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 1zz2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2ZAZA Q16539 4 352 360.0 GK1:362 Type1 Inactive DFGin 7.3994 15.9398 BLBplus -115.23, 176.01 60.89, 77.69 -123.12, 161.77 6.94, 26.13 78.38, 12.21 in-in in 9.4181 Saltbr-in 2.6795 HRD-in -66.73, -53.6 82.05, -15.76 in-out-out SNCioo out-out ActLoopNT-out 11.3262 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 133.41 APE9-dihe-na -61.36, -17.74 APE8-dihe-out -62.47, -15.93 APE8-rot-out 52.34 APE67-dihe-in -63.58, -18.92 -121.06, -15.96 APE12-dist-out 21.2963 APE11-dist-out 23.1344 APE10-dist-out 17.2671 APE9-dist-out 11.7778 None None None XRAY 1.8 0.199 0.234 A 360.0 345.0 4 25 25 0 [[24, 308]] 1.0 2zaz CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3D7ZA Q16539 4 352 360.0 GK5:401 Type1 Inactive DFGin 5.4719 13.9052 BLBplus -110.05, 159.12 71.33, 19.43 -70.41, 155.49 43.03, 84.34 62.35, 11.69 in-in in 8.6765 Saltbr-in 2.588 HRD-in -70.59, -57.12 79.42, -20.6 in-out-out SNCioo out-out ActLoopNT-out 9.0845 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -139.41, 134.0 APE9-dihe-na -61.33, -22.23 APE8-dihe-out -58.46, -25.27 APE8-rot-out 52.6 APE67-dihe-in -66.01, -21.29 -109.77, -17.38 APE12-dist-out 22.308 APE11-dist-out 24.2828 APE10-dist-out 18.6655 APE9-dist-out 11.8802 None None CSO119 XRAY 2.1 0.177 0.227 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 3d7z CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3IPHA Q16539 4 352 360.0 G11:361 Type1 Inactive DFGin 5.8072 14.1611 BLBplus -118.73, 162.65 67.18, 18.11 -71.69, 160.43 43.35, 83.27 65.65, 15.53 in-in in 8.7563 Saltbr-in 2.6906 HRD-in -74.71, -57.61 79.14, -23.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -144.35, 133.12 APE9-dihe-na -56.61, -21.99 APE8-dihe-out -64.41, -16.18 APE8-rot-out 54.9 APE67-dihe-in -64.39, -19.25 -118.43, -15.06 APE12-dist-out 22.3267 APE11-dist-out 24.2942 APE10-dist-out 18.8533 APE9-dist-out 11.648 None None CSO119,CSO162 XRAY 2.1 0.184 0.249 A 360.0 347.0 2 25 23 2 [[24, 308]] 1.0 3iph CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3KF7A Q16539 5 352 360.0 L9G:60401 Type1 Inactive DFGin 5.1086 13.1627 BLBplus -108.18, 151.36 65.29, 12.11 -35.39, 152.89 38.26, 90.38 72.15, -32.28 in-in in 9.0328 Saltbr-in 2.8286 HRD-in -67.37, -53.91 79.87, -15.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 60.06 APE9-dihe-na -69.4, 135.81 APE8-dihe-out -55.41, -37.65 APE8-rot-none 999.0 APE67-dihe-in -61.12, -27.93 -46.48, -41.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.6647 APE9-dist-out 10.9338 None None None XRAY 2.0 0.235 0.274 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3kf7 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3RINA Q16539 4 352 360.0 I2O:401 Type1 Inactive DFGin 5.0815 13.6204 BLBplus -114.0, 158.6 70.65, 16.99 -65.1, 140.89 33.49, 80.3 69.95, 1.93 in-in in 8.9372 Saltbr-in 2.9241 HRD-in -55.11, -53.67 73.84, -19.05 in-out-out SNCioo out-out ActLoopNT-out 9.7945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.29, 128.8 APE9-dihe-na -57.87, -15.63 APE8-dihe-out -75.69, 1.27 APE8-rot-out 82.63 APE67-dihe-in -61.25, -17.28 -132.79, -15.39 APE12-dist-out 21.9743 APE11-dist-out 23.8177 APE10-dist-out 18.1676 APE9-dist-out 12.0826 None None None XRAY 2.2 0.265 0.308 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 3rin CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5MTXA Q16539 5 352 360.0 FJI:401 Type1 Inactive DFGin 5.4582 14.136 BLBplus -112.91, 158.05 62.91, 38.11 -88.92, 163.57 43.19, 91.49 71.06, 5.17 in-in in 8.9094 Saltbr-in 2.7487 HRD-in -70.36, -56.47 76.64, -11.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.61 APE8-rot-out 184.43 APE67-dihe-in -61.4, -22.03 -104.95, 4.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.191 0.233 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 5mtx CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5MTYA Q16539 5 352 360.0 HB9:401 Type1 Inactive DFGin 5.7438 14.0709 BLBplus -117.73, 163.81 48.17, 40.91 -75.75, 165.15 37.67, 90.02 34.98, 999.0 in-in in 8.8783 Saltbr-in 2.8604 HRD-in -72.44, -55.72 86.74, -19.51 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.18 APE8-rot-in 291.54 APE67-dihe-in -71.41, -22.48 -112.24, 10.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.271 A 360.0 328.0 20 25 11 14 [[24, 308]] 1.0 5mty CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5TBEA Q16539 5 353 360.0 78L:401 Type1 Inactive DFGin 6.4774 14.8835 BLBplus -93.8, 144.39 61.93, 30.09 -73.07, 151.97 64.35, 85.26 84.23, 2.96 in-in in 9.1049 Saltbr-in 2.654 HRD-in -76.42, -61.38 82.77, -33.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.07, -13.0 999.0, -13.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.44 0.189 0.254 A 360.0 332.0 17 25 12 13 [[24, 308]] 1.0 5tbe CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9Y8BA Q16539 5 353 360.0 A1CTD:402 Type1 Inactive DFGin 4.6239 13.7198 BLBplus -109.52, 154.53 68.6, 22.27 -61.66, 145.35 41.31, 108.5 67.82, 16.21 in-in in 9.5503 Saltbr-in 2.6796 HRD-in -68.81, -56.85 82.39, -13.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.28 APE8-dihe-in -125.2, 155.55 APE8-rot-out 54.38 APE67-dihe-out -71.64, -13.87 -27.27, 104.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 15.6486 None None None XRAY 1.97 0.183 0.221 A 360.0 338.0 11 25 14 11 [[24, 308]] 1.0 9y8b CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5TCOA Q16539 6 352 360.0 79Q:401 Type1 Inactive DFGin 5.2616 14.1159 BLBplus -107.56, 157.64 61.22, 34.19 -83.48, 153.07 46.33, 88.09 65.12, 36.29 in-in in 8.7421 Saltbr-in 2.7328 HRD-in -80.38, -60.51 87.12, -16.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -43.63 APE8-rot-in 285.59 APE67-dihe-in -62.06, -23.45 -95.94, 3.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.217 0.27 A 360.0 327.0 20 25 12 13 [[24, 308]] 1.0 5tco CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9Q5BA Q16539 5 353 360.0 A1CRZ:402 Type1 Inactive DFGin 4.8761 13.5709 BLBplus -103.71, 161.3 50.9, 30.92 -62.56, 151.06 41.69, 95.46 46.76, 33.42 in-in in 9.4764 Saltbr-in 2.8269 HRD-in -72.21, -56.01 76.62, -12.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.15 APE8-dihe-out -62.65, -30.96 APE8-rot-out 172.83 APE67-dihe-in -64.1, -23.31 -55.81, -28.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6399 None None CME162 XRAY 2.05 0.193 0.236 A 362.0 333.0 16 25 13 12 [[24, 308]] 1.0 9q5b CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6M9LA Q16539 5 352 360.0 J9G:501 Type1 Inactive DFGin 5.0139 13.2894 BLBplus -126.64, 146.45 61.95, 34.85 -65.96, 149.32 34.74, 88.86 64.07, 999.0 in-in in 8.8657 Saltbr-in 2.9824 HRD-in -71.33, -38.03 72.28, -19.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.78 APE8-rot-out 177.34 APE67-dihe-in -76.69, -14.09 -105.81, 3.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.216 0.27 A 388.0 331.0 17 25 11 14 [[24, 308]] 1.0 6m9l CMGC_MAPK14_HUMAN CMGC 2e-84 289.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3DS6A Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.3658 14.6548 BLBplus -122.93, 172.79 47.41, 37.04 -83.59, 151.14 48.87, 79.98 61.26, 21.03 in-in in 9.7737 Saltbr-in 3.0728 HRD-in -72.1, -49.23 78.27, -31.31 in-out-out SNCioo out-out ActLoopNT-out 9.2636 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -164.1 APE9-dihe-na 70.58, 125.16 APE8-dihe-in -55.31, 146.03 APE8-rot-out 71.52 APE67-dihe-in -65.93, -10.4 -130.08, 13.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.6227 APE9-dist-out 10.3084 None None None XRAY 2.9 0.228 0.319 A 366.0 343.0 6 25 19 6 [[24, 308]] 1.0 3ds6 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3DS6B Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.4731 14.4755 BLBplus -123.62, 166.77 55.02, 30.8 -85.61, 160.65 52.06, 76.39 59.15, 32.95 in-in in 9.0027 Saltbr-in 2.82 HRD-in -80.61, -61.75 77.29, 8.66 in-out-out SNCioo out-out ActLoopNT-out 9.3691 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 142.95 APE9-dihe-na 79.62, 112.64 APE8-dihe-in -54.08, 137.84 APE8-rot-out 77.26 APE67-dihe-in -52.14, -19.33 -111.76, 8.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4367 APE9-dist-out 10.1017 None None None XRAY 2.9 0.228 0.319 B 366.0 343.0 6 25 19 6 [[24, 308]] 1.0 3ds6 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3DS6C Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.9833 14.4693 BLBplus -127.13, 170.87 50.14, 37.25 -87.87, 170.72 41.22, 87.61 57.99, 29.61 in-in in 8.8118 Saltbr-in 3.0637 HRD-in -66.29, -53.6 81.12, -16.31 in-out-out SNCioo out-out ActLoopNT-out 8.8576 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -56.14, 143.7 APE9-dihe-na -91.25, 29.56 APE8-dihe-out -111.78, 23.16 APE8-rot-out 74.82 APE67-dihe-in -64.75, -24.89 -135.72, -8.12 APE12-dist-out 21.2133 APE11-dist-out 22.9514 APE10-dist-out 17.083 APE9-dist-out 12.4953 None None None XRAY 2.9 0.228 0.319 C 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3ds6 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3DS6D Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.2401 14.4797 BLBplus -127.49, 166.91 61.08, 14.93 -65.95, 148.58 51.55, 94.54 79.43, 72.03 in-in in 9.5006 Saltbr-in 3.1285 HRD-in -80.05, -51.35 75.1, -31.54 in-out-out SNCioo out-out ActLoopNT-out 10.1352 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.1, 162.6 APE9-dihe-na 76.6, -149.02 APE8-dihe-in -151.85, 111.76 APE8-rot-out 41.83 APE67-dihe-in -38.68, -38.29 -96.24, -18.63 APE12-dist-out 18.9801 APE11-dist-out 20.1236 APE10-dist-out 15.9022 APE9-dist-out 10.8817 None None None XRAY 2.9 0.228 0.319 D 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3ds6 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GFEA Q16539 1 352 360.0 P37:361 Type1 Inactive DFGin 5.1879 13.8082 BLBplus -115.86, 165.88 67.19, 19.31 -64.73, 142.19 40.91, 86.55 76.47, 0.22 in-in in 8.7663 Saltbr-in 2.6838 HRD-in -66.42, -56.03 78.03, -8.83 in-out-out SNCioo out-out ActLoopNT-out 10.3917 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.92, 132.97 APE9-dihe-na -62.32, -20.23 APE8-dihe-out -60.82, -21.97 APE8-rot-out 57.38 APE67-dihe-in -61.5, -24.14 -110.53, -18.99 APE12-dist-out 22.291 APE11-dist-out 24.2092 APE10-dist-out 18.4964 APE9-dist-out 12.4045 None None None XRAY 2.1 0.218 0.25 A 366.0 352.0 0 25 25 0 [[24, 308]] 1.0 3gfe CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ITZA Q16539 1 353 360.0 P66:60401 Type1 Inactive DFGin 4.9585 13.9183 BLBplus -107.9, 162.3 63.06, 31.58 -72.36, 146.38 38.16, 83.23 67.02, 10.18 in-in in 9.1003 Saltbr-in 2.7241 HRD-in -69.01, -57.02 88.24, -30.51 in-out-out SNCioo out-out ActLoopNT-out 10.0916 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.42, 134.26 APE9-dihe-na -58.35, -29.26 APE8-dihe-out -54.12, -23.64 APE8-rot-out 64.73 APE67-dihe-in -59.15, -23.05 -112.8, -19.77 APE12-dist-out 22.4167 APE11-dist-out 24.3629 APE10-dist-out 18.6782 APE9-dist-out 12.2003 None None None XRAY 2.25 0.216 0.249 A 366.0 353.0 0 25 25 0 [[24, 308]] 1.0 3itz CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LHJA Q16539 5 352 360.0 LHJ:361 Type1 Inactive DFGin 5.3359 13.8777 BLBplus -115.51, 163.31 63.03, 29.36 -80.13, 152.17 45.31, 85.49 71.44, 9.33 in-in in 8.9535 Saltbr-in 2.5974 HRD-in -75.58, -60.18 86.33, -20.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -125.96, 147.96 APE9-dihe-na -81.76, -12.73 APE8-dihe-out -71.4, -13.81 APE8-rot-out 58.36 APE67-dihe-in -65.64, -7.53 -102.09, -20.01 APE12-dist-out 21.8415 APE11-dist-out 23.9653 APE10-dist-out 18.2066 APE9-dist-out 12.6099 None None None XRAY 3.31 0.217 0.289 A 366.0 341.0 7 25 18 7 [[24, 308]] 1.0 3lhj CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3U8WA Q16539 4 352 360.0 09J:500 Type1 Inactive DFGin 5.002 14.1816 BLBplus -111.96, 165.8 69.87, 20.22 -68.93, 147.04 41.63, 87.6 71.46, 7.86 in-in in 8.9829 Saltbr-in 2.6753 HRD-in -69.12, -58.03 64.43, 7.59 in-out-out SNCioo out-out ActLoopNT-out 9.2818 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.78, 133.32 APE9-dihe-na -62.08, -21.59 APE8-dihe-out -57.48, -25.08 APE8-rot-out 54.07 APE67-dihe-in -63.09, -21.57 -110.32, -18.62 APE12-dist-out 21.8294 APE11-dist-out 23.851 APE10-dist-out 18.1713 APE9-dist-out 12.0393 None None None XRAY 2.15 0.235 0.255 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3u8w CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2BALA Q16539 5 353 360.0 PQA:401 Type1 Inactive DFGin 5.065 13.8126 BLBplus -114.2, 157.25 64.96, 21.25 -58.19, 154.52 45.13, 93.16 67.4, 7.35 in-in in 8.9284 Saltbr-in 2.6678 HRD-in -66.82, -54.57 78.19, -14.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.42 APE8-dihe-out -62.64, -34.45 APE8-rot-out 221.94 APE67-dihe-in -60.27, -23.35 -60.34, -26.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8096 None None CSS162 XRAY 2.1 0.22 0.265 A 365.0 338.0 11 25 14 11 [[24, 308]] 1.0 2bal CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4AA4A Q16539 5 355 360.0 QC0:1356 Type1 Inactive DFGin 5.554 14.3889 BLBplus -110.75, 162.11 67.45, 15.6 -63.63, 154.39 40.31, 96.48 76.38, 8.0 in-in in 9.0234 Saltbr-in 2.685 HRD-in -62.75, -59.41 81.03, -20.48 in-out-out SNCioo out-out ActLoopNT-out 8.141 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -102.14, 114.46 APE9-dihe-na -82.19, 164.99 APE8-dihe-in -107.68, 123.81 APE8-rot-in 313.88 APE67-dihe-in -64.7, -21.49 -49.45, -47.92 APE12-dist-in 8.9325 APE11-dist-out 5.1054 APE10-dist-out 10.7388 APE9-dist-out 6.2572 None None None XRAY 2.3 0.214 0.255 A 365.0 347.0 4 25 25 0 [[24, 308]] 1.0 4aa4 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4AA5A Q16539 5 352 360.0 NQB:1353 Type1 Inactive DFGin 5.8955 14.4336 BLBplus -115.01, 160.41 74.09, 14.28 -68.41, 156.78 48.17, 83.43 73.38, -0.15 in-in in 9.0239 Saltbr-in 2.5348 HRD-in -69.21, -57.74 77.98, -20.09 in-out-out SNCioo out-out ActLoopNT-out 8.2398 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -101.94, 113.07 APE9-dihe-na -84.46, 166.95 APE8-dihe-in -111.34, 114.37 APE8-rot-in 305.83 APE67-dihe-in -60.23, -23.5 -47.25, -45.26 APE12-dist-in 9.0301 APE11-dist-out 5.1957 APE10-dist-out 10.7506 APE9-dist-out 6.4779 None None CSS162 XRAY 2.38 0.218 0.26 A 365.0 341.0 7 25 22 3 [[24, 308]] 1.0 4aa5 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4AACA Q16539 5 359 360.0 AAV:1360 Type1 Inactive DFGin 5.5863 14.7093 BLBplus -109.28, 158.52 65.37, 19.6 -65.62, 151.47 45.42, 91.42 69.1, 20.42 in-in in 8.8926 Saltbr-in 2.6681 HRD-in -58.62, -59.28 76.85, -14.52 in-out-out SNCioo out-out ActLoopNT-out 8.2565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -96.42, 111.28 APE9-dihe-na -75.75, 165.33 APE8-dihe-in -110.09, 114.94 APE8-rot-in 304.67 APE67-dihe-in -70.87, -14.11 -43.79, -36.88 APE12-dist-in 8.974 APE11-dist-out 5.3396 APE10-dist-out 10.7909 APE9-dist-out 6.2814 None None None XRAY 2.5 0.234 0.305 A 365.0 350.0 5 25 25 0 [[24, 308]] 1.0 4aac CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2QD9A Q16539 5 352 360.0 LGF:361 Type1 Inactive DFGin 5.1343 13.7971 BLBplus -108.86, 148.96 74.79, 24.8 -73.05, 150.79 49.54, 82.76 82.07, 6.15 in-in in 9.155 Saltbr-in 2.5566 HRD-in -76.06, -55.95 78.8, -20.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.56, -22.52 999.0, -59.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.252 0.282 A 366.0 330.0 18 25 12 13 [[24, 308]] 1.0 2qd9 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MVLA Q16539 5 353 360.0 38P:361 Type1 Inactive DFGin 5.9231 13.9396 BLBplus -119.06, 172.25 43.96, 31.01 -75.04, 165.39 47.04, 85.22 49.98, 13.01 in-in in 8.8486 Saltbr-in 2.5606 HRD-in -92.72, -54.18 74.73, 5.28 in-out-none SNCion out-none ActLoopNT-out 8.5019 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.46 APE8-rot-in 313.41 APE67-dihe-in -57.45, -35.22 -63.53, -26.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.335 A 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 3mvl CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MVLB Q16539 5 353 360.0 38P:361 Type1 Inactive DFGin 5.8783 14.202 BLBplus -107.75, 146.07 75.29, -5.13 -46.54, 143.19 54.91, 98.87 68.67, 7.96 in-in in 8.9821 Saltbr-in 2.6996 HRD-in -70.81, -51.73 77.53, -13.13 in-out-none SNCion out-none ActLoopNT-out 7.1992 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.44 APE8-rot-in 326.95 APE67-dihe-in -59.91, -44.52 -72.93, -14.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.335 B 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 3mvl CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MVMA Q16539 4 352 360.0 39P:361 Type1 Inactive DFGin 5.1124 14.6414 BLBplus -109.05, 158.07 60.08, 30.28 -73.72, 142.65 52.92, 91.21 70.7, -1.72 in-in in 9.0784 Saltbr-in 2.6241 HRD-in -63.63, -54.52 81.45, -25.37 in-out-out SNCioo out-out ActLoopNT-out 7.7603 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -96.85 APE8-rot-in 340.3 APE67-dihe-out -65.9, -21.64 122.83, -4.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.238 A 366.0 335.0 14 25 16 9 [[24, 308]] 1.0 3mvm CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MVMB Q16539 5 351 360.0 39P:361 Type1 Inactive DFGin 4.9534 14.5909 BLBplus -108.83, 159.13 58.86, 31.42 -73.06, 137.72 52.17, 94.17 71.9, 9.12 in-in in 9.0283 Saltbr-in 2.5452 HRD-in -63.09, -54.14 78.68, -22.23 in-out-out SNCioo out-out ActLoopNT-out 6.9438 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.38 APE8-rot-out 71.13 APE67-dihe-out -67.11, -20.05 -128.98, 52.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.238 B 366.0 332.0 15 25 14 11 [[24, 308]] 1.0 3mvm CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3NWWA Q16539 5 353 360.0 3NW:361 Type1 Inactive DFGin 5.2842 13.8833 BLBplus -115.86, 167.05 59.08, 20.31 -67.36, 154.78 45.75, 85.87 66.49, 8.6 in-in in 9.0204 Saltbr-in 2.5893 HRD-in -68.85, -58.97 77.98, -20.29 in-out-none SNCion out-none ActLoopNT-out 8.2156 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.6 APE8-rot-in 307.95 APE67-dihe-in -62.74, -26.81 -46.77, -33.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.214 0.254 A 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 3nww CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3S4QA Q16539 4 352 360.0 NK0:361 Type1 Inactive DFGin 5.8843 14.169 BLBplus -109.03, 159.91 64.82, 29.39 -78.97, 147.58 44.64, 92.49 62.53, 17.35 in-in in 9.2313 Saltbr-in 2.8004 HRD-in -67.25, -52.03 73.36, -6.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.53 APE8-dihe-out -127.21, -24.07 APE8-rot-out 58.0 APE67-dihe-in -56.34, -41.67 -80.95, 5.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.5617 None None None XRAY 2.27 0.26 0.327 A 366.0 326.0 23 25 14 11 [[24, 308]] 1.0 3s4q CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KINA Q16539 5 352 360.0 1M8:401 Type1 Inactive DFGin 5.8298 14.4907 BLBplus -112.0, 159.56 58.84, 31.67 -80.2, 161.77 51.23, 91.19 70.21, 3.94 in-in in 9.3321 Saltbr-in 2.6928 HRD-in -75.58, -60.36 79.72, -18.44 in-out-out SNCioo out-out ActLoopNT-out 7.8786 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -81.36, 45.06 APE9-dihe-na -160.68, 148.72 APE8-dihe-in -80.55, 140.18 APE8-rot-out 52.55 APE67-dihe-out -62.92, -22.56 -122.89, 54.77 APE12-dist-none 999.0 APE11-dist-out 19.6485 APE10-dist-out 19.6951 APE9-dist-out 12.8871 None None None XRAY 1.97 0.186 0.217 A 366.0 338.0 10 25 17 8 [[24, 308]] 1.0 4kin CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KINB Q16539 4 352 360.0 1M8:401 Type1 Inactive DFGin 5.8331 14.3759 BLBplus -111.81, 160.82 58.79, 31.15 -82.0, 162.48 50.94, 86.22 67.7, 5.09 in-in in 9.2716 Saltbr-in 2.7051 HRD-in -77.44, -59.82 78.53, -17.64 in-out-out SNCioo out-out ActLoopNT-out 8.1687 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -117.05, 92.32 APE9-dihe-na -152.42, 131.25 APE8-dihe-in -58.54, 143.39 APE8-rot-out 65.06 APE67-dihe-in -56.63, -20.78 -125.76, 48.86 APE12-dist-none 999.0 APE11-dist-out 19.6528 APE10-dist-out 21.2323 APE9-dist-out 13.1311 None None None XRAY 1.97 0.186 0.217 B 366.0 341.0 8 25 17 8 [[24, 308]] 1.0 4kin CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KINC Q16539 4 352 360.0 1M8:401 Type1 Inactive DFGin 5.8223 14.3313 BLBplus -112.14, 159.92 56.39, 32.68 -82.61, 164.95 50.22, 87.86 66.13, 5.77 in-in in 9.2196 Saltbr-in 2.6995 HRD-in -77.09, -60.2 79.61, -18.38 in-out-out SNCioo out-out ActLoopNT-out 8.1313 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.85 APE8-dihe-in -67.36, 151.26 APE8-rot-out 182.89 APE67-dihe-in -64.44, -23.22 -157.89, 24.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7995 None None None XRAY 1.97 0.186 0.217 C 366.0 338.0 11 25 16 9 [[24, 308]] 1.0 4kin CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIND Q16539 4 354 360.0 1M8:401 Type1 Inactive DFGin 5.8375 13.9246 BLBplus -113.2, 160.86 57.37, 29.91 -79.52, 159.49 50.89, 87.6 72.34, 0.42 in-in in 8.8613 Saltbr-in 2.7368 HRD-in -76.52, -60.3 80.07, -18.04 in-out-out SNCioo out-out ActLoopNT-out 8.1205 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 62.74 APE8-dihe-in -59.81, 147.68 APE8-rot-out 180.07 APE67-dihe-in -62.05, -22.47 -108.39, 8.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4245 None None None XRAY 1.97 0.186 0.217 D 366.0 339.0 12 25 16 9 [[24, 308]] 1.0 4kin CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIPA Q16539 5 352 360.0 1R9:401 Type1 Inactive DFGin 5.7084 14.0793 BLBplus -114.41, 163.55 55.79, 23.53 -69.06, 154.65 55.02, 86.64 54.99, 29.98 in-in in 9.0858 Saltbr-in 2.823 HRD-in -67.01, -55.42 76.27, -22.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 11.59 APE8-dihe-out -146.39, -50.33 APE8-rot-in 311.75 APE67-dihe-in -68.64, -8.71 -84.46, 20.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0937 None None None XRAY 2.27 0.255 0.286 A 366.0 337.0 11 25 14 11 [[24, 308]] 1.0 4kip CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIPB Q16539 5 352 360.0 1R9:401 Type1 Inactive DFGin 5.7167 14.1161 BLBplus -114.1, 163.8 56.21, 23.48 -69.68, 154.48 55.05, 86.85 56.34, 29.94 in-in in 9.096 Saltbr-in 2.8383 HRD-in -67.08, -55.59 76.29, -22.57 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 132.1 APE9-dihe-na -60.21, -31.7 APE8-dihe-out -86.79, -6.39 APE8-rot-out 45.77 APE67-dihe-in -67.99, -26.43 -108.37, 17.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.8599 APE9-dist-out 13.386 None None None XRAY 2.27 0.255 0.286 B 366.0 338.0 10 25 15 10 [[24, 308]] 1.0 4kip CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIQA Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.9141 14.158 BLBplus -118.42, 161.56 57.68, 30.65 -79.17, 161.61 47.63, 93.06 67.87, 7.88 in-in in 9.1021 Saltbr-in 2.7625 HRD-in -78.21, -56.73 75.15, -8.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.16 APE8-dihe-in -53.19, 141.15 APE8-rot-none 999.0 APE67-dihe-in -58.65, -22.95 -105.79, 0.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0034 None None None XRAY 2.5 0.186 0.228 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIQB Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.8426 14.3685 BLBplus -116.24, 159.69 59.04, 30.62 -78.88, 159.93 47.84, 94.08 67.34, 8.96 in-in in 9.2385 Saltbr-in 2.7593 HRD-in -79.0, -55.49 80.13, -20.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.88 APE8-dihe-in -44.28, 116.69 APE8-rot-none 999.0 APE67-dihe-out -64.05, -20.17 -121.62, 60.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6678 None None None XRAY 2.5 0.186 0.228 B 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIQC Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.9161 14.363 BLBplus -118.73, 158.67 59.65, 31.16 -79.36, 160.3 48.33, 82.72 66.37, 9.63 in-in in 9.2238 Saltbr-in 2.7828 HRD-in -79.74, -56.13 77.72, -18.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.44 APE8-dihe-in -69.87, 141.68 APE8-rot-none 999.0 APE67-dihe-in -60.47, -18.91 -131.63, 43.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3285 None None None XRAY 2.5 0.186 0.228 C 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4KIQD Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.9014 14.2596 BLBplus -118.2, 159.83 57.68, 31.41 -79.47, 160.77 46.83, 92.7 66.38, 10.78 in-in in 9.1675 Saltbr-in 2.7212 HRD-in -78.42, -57.5 78.74, -19.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -179.73 APE8-dihe-in -130.42, 158.74 APE8-rot-none 999.0 APE67-dihe-out -79.12, -17.03 -134.99, 147.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.1114 None None None XRAY 2.5 0.186 0.228 D 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FKLA Q16539 4 352 360.0 FKL:361 Type1 Inactive DFGin 5.6671 14.2402 BLBplus -114.22, 158.36 70.3, 22.27 -77.13, 155.27 49.6, 86.33 76.39, 7.75 in-in in 9.0943 Saltbr-in 2.5361 HRD-in -68.8, -61.26 80.02, -18.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.3, 137.72 APE9-dihe-na -61.94, -7.95 APE8-dihe-out -75.24, -17.17 APE8-rot-out 63.55 APE67-dihe-in -64.84, -19.66 -117.76, -15.17 APE12-dist-out 22.4401 APE11-dist-out 24.5382 APE10-dist-out 18.8966 APE9-dist-out 12.0382 None None None XRAY 2.0 0.221 0.254 A 372.0 344.0 5 25 20 5 [[24, 308]] 1.0 3fkl CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FKNA Q16539 4 352 360.0 FKN:361 Type1 Inactive DFGin 4.7904 13.1791 BLBplus -103.92, 161.19 68.94, 15.34 -60.02, 144.92 37.34, 90.85 95.68, 999.0 in-in in 9.1446 Saltbr-in 2.8037 HRD-in -68.47, -52.64 81.71, -16.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.64, 134.39 APE9-dihe-na -62.8, -16.56 APE8-dihe-out -67.68, -16.81 APE8-rot-out 53.51 APE67-dihe-in -61.37, -24.12 -116.82, -19.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0157 None None None XRAY 2.0 0.215 0.242 A 372.0 346.0 3 25 22 3 [[24, 308]] 1.0 3fkn CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FL4A Q16539 4 352 360.0 FL4:361 Type1 Inactive DFGin 4.8043 13.479 BLBplus -111.14, 160.38 67.95, 24.65 -67.44, 145.81 38.5, 85.33 70.07, 999.0 in-in in 9.1978 Saltbr-in 2.8087 HRD-in -65.46, -57.78 85.76, -17.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -132.91, 132.36 APE9-dihe-na -59.93, -23.61 APE8-dihe-out -59.15, -20.92 APE8-rot-out 61.36 APE67-dihe-in -62.92, -20.8 -113.88, -17.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2204 None None None XRAY 1.8 0.218 0.243 A 372.0 339.0 10 25 21 4 [[24, 308]] 1.0 3fl4 CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FLSA Q16539 4 352 360.0 FLS:361 Type1 Inactive DFGin 4.6684 13.8126 BLBplus -113.35, 162.5 69.6, 18.68 -67.04, 145.99 47.14, 89.36 71.76, 9.42 in-in in 9.0455 Saltbr-in 2.4805 HRD-in -66.61, -45.2 72.22, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.1, 133.44 APE9-dihe-na -60.87, -7.92 APE8-dihe-out -75.41, -18.86 APE8-rot-out 57.36 APE67-dihe-in -58.7, -26.83 -117.81, -17.11 APE12-dist-out 22.1926 APE11-dist-out 24.1021 APE10-dist-out 18.4502 APE9-dist-out 12.39 None None None XRAY 2.3 0.25 0.294 A 372.0 343.0 6 25 23 2 [[24, 308]] 1.0 3fls CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FLWA Q16539 4 352 360.0 FLW:361 Type1 Inactive DFGin 4.9914 14.2902 BLBplus -111.65, 161.12 63.95, 35.17 -86.23, 155.47 50.75, 86.69 80.75, 999.0 in-in in 9.1134 Saltbr-in 2.5483 HRD-in -66.96, -51.63 76.82, -13.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.69, 136.03 APE9-dihe-na -60.46, -18.68 APE8-dihe-out -65.02, -23.67 APE8-rot-out 50.34 APE67-dihe-in -62.62, -24.23 -110.6, -16.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9335 None None None XRAY 2.1 0.213 0.237 A 372.0 345.0 3 25 22 3 [[24, 308]] 1.0 3flw CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FLYA Q16539 4 352 360.0 FLY:361 Type1 Inactive DFGin 4.9041 14.2356 BLBplus -110.95, 154.46 66.68, 35.35 -80.29, 147.81 44.1, 87.62 72.1, 16.43 in-in in 9.1852 Saltbr-in 2.4661 HRD-in -67.73, -54.84 84.66, -16.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.85, 135.56 APE9-dihe-na -62.9, -18.3 APE8-dihe-out -63.51, -18.52 APE8-rot-out 55.5 APE67-dihe-in -61.31, -21.95 -117.65, -19.04 APE12-dist-out 21.9761 APE11-dist-out 24.0595 APE10-dist-out 18.3714 APE9-dist-out 11.9189 None None None XRAY 1.8 0.22 0.245 A 372.0 347.0 2 25 23 2 [[24, 308]] 1.0 3fly CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FLZA Q16539 4 352 360.0 FLZ:361 Type1 Inactive DFGin 5.0224 14.5597 BLBplus -112.56, 159.04 69.03, 31.91 -85.37, 150.96 47.3, 88.83 71.95, 20.33 in-in in 9.3011 Saltbr-in 2.675 HRD-in -67.62, -51.08 81.59, -16.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.57, 136.86 APE9-dihe-na -59.65, -16.05 APE8-dihe-out -70.93, -17.35 APE8-rot-out 54.38 APE67-dihe-in -62.29, -21.11 -113.79, -19.95 APE12-dist-out 22.0928 APE11-dist-out 24.1903 APE10-dist-out 18.512 APE9-dist-out 12.1512 None None None XRAY 2.23 0.214 0.251 A 372.0 347.0 2 25 23 2 [[24, 308]] 1.0 3flz CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FMHA Q16539 4 352 360.0 533:361 Type1 Inactive DFGin 4.8698 13.955 BLBplus -105.43, 156.22 65.66, 28.54 -72.9, 146.69 42.62, 89.43 73.67, 16.55 in-in in 9.2456 Saltbr-in 2.5881 HRD-in -66.12, -54.34 83.29, -19.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.51, 136.05 APE9-dihe-na -60.18, -18.37 APE8-dihe-out -63.92, -21.68 APE8-rot-out 63.81 APE67-dihe-in -64.6, -20.22 -113.62, -15.72 APE12-dist-out 21.982 APE11-dist-out 24.0881 APE10-dist-out 18.4408 APE9-dist-out 12.1626 None None None XRAY 1.9 0.218 0.246 A 372.0 347.0 2 25 23 2 [[24, 308]] 1.0 3fmh CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FMKA Q16539 4 352 360.0 FMK:361 Type1 Inactive DFGin 4.9247 13.7994 BLBplus -112.17, 148.9 62.85, 38.56 -78.11, 150.42 42.19, 85.47 69.39, 15.49 in-in in 9.1489 Saltbr-in 2.6332 HRD-in -67.87, -55.08 82.14, -17.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.81, 134.32 APE9-dihe-na -62.69, -17.2 APE8-dihe-out -65.89, -17.03 APE8-rot-out 56.12 APE67-dihe-in -61.48, -22.33 -117.35, -20.7 APE12-dist-out 22.1271 APE11-dist-out 24.1209 APE10-dist-out 18.4211 APE9-dist-out 11.9605 None None None XRAY 1.7 0.204 0.224 A 372.0 346.0 3 25 22 3 [[24, 308]] 1.0 3fmk CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FMMA Q16539 4 352 360.0 XI2:361 Type1 Inactive DFGin 4.7682 13.4507 BLBplus -98.73, 158.86 67.25, 21.18 -69.18, 146.01 43.41, 87.89 71.96, 10.19 in-in in 9.2237 Saltbr-in 2.6641 HRD-in -65.66, -56.28 86.92, -21.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.47, 134.19 APE9-dihe-na -60.38, -14.86 APE8-dihe-out -69.41, -16.91 APE8-rot-out 61.13 APE67-dihe-in -65.56, -21.54 -116.99, -14.56 APE12-dist-out 22.2545 APE11-dist-out 24.3333 APE10-dist-out 18.646 APE9-dist-out 12.268 None None None XRAY 2.0 0.214 0.242 A 372.0 346.0 3 25 22 3 [[24, 308]] 1.0 3fmm CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FMNA Q16539 4 352 360.0 530:361 Type1 Inactive DFGin 4.8329 13.4655 BLBplus -104.04, 155.55 66.08, 26.65 -71.48, 145.7 42.74, 89.21 83.26, 999.0 in-in in 9.0751 Saltbr-in 2.7869 HRD-in -67.59, -53.8 83.21, -19.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -133.88, 134.88 APE9-dihe-na -63.74, -14.43 APE8-dihe-out -64.98, -21.19 APE8-rot-out 59.83 APE67-dihe-in -62.49, -23.26 -114.32, -17.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.095 None None None XRAY 1.9 0.206 0.242 A 372.0 341.0 8 25 21 4 [[24, 308]] 1.0 3fmn CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3E92A Q16539 3 352 360.0 G6A:361 Type1 Inactive DFGin 5.54 13.9383 BLBplus -118.48, 163.03 66.45, 15.69 -63.59, 154.46 39.99, 80.08 65.45, 13.13 in-in in 8.6059 Saltbr-in 2.593 HRD-in -66.1, -56.76 76.48, -15.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.92, 133.57 APE9-dihe-na -59.41, -20.48 APE8-dihe-out -64.59, -18.95 APE8-rot-out 58.81 APE67-dihe-in -65.96, -18.46 -116.06, -15.19 APE12-dist-out 22.2163 APE11-dist-out 24.2329 APE10-dist-out 18.5555 APE9-dist-out 11.8632 None None CSO162 XRAY 2.0 0.174 0.216 A 371.0 349.0 1 25 24 1 [[24, 308]] 1.0 3e92 CMGC_MAPK14_HUMAN CMGC 6.5e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MPTA Q16539 4 352 360.0 1GK:361 Type1 Inactive DFGin 5.038 13.9306 BLBplus -127.08, 159.45 63.85, 35.02 -73.68, 152.66 31.46, 78.25 53.08, 37.18 in-in in 9.1792 Saltbr-in 2.6372 HRD-in -74.41, -57.49 77.98, -16.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.14, 130.25 APE9-dihe-na -58.41, -25.43 APE8-dihe-out -57.22, -18.71 APE8-rot-out 61.81 APE67-dihe-in -64.25, -20.9 -117.57, -13.29 APE12-dist-out 21.5931 APE11-dist-out 23.6672 APE10-dist-out 17.9131 APE9-dist-out 11.5686 None None None XRAY 1.89 0.239 0.298 A 371.0 347.0 2 25 23 2 [[24, 308]] 1.0 3mpt CMGC_MAPK14_HUMAN CMGC 6.5e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3DT1A Q16539 1 352 360.0 P40:60361 Type1 Inactive DFGin 5.2661 13.9573 BLBplus -113.29, 169.9 39.88, 60.05 -100.91, 153.78 42.94, 70.44 60.38, 18.47 in-in in 8.9251 Saltbr-in 3.0344 HRD-in -74.95, -48.4 72.93, -13.41 in-out-out SNCioo out-out ActLoopNT-out 9.5746 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -124.97, 138.41 APE9-dihe-na -69.69, -13.12 APE8-dihe-out -63.44, -40.84 APE8-rot-out 61.54 APE67-dihe-in -94.37, -9.12 -96.58, 18.94 APE12-dist-out 22.079 APE11-dist-out 24.1624 APE10-dist-out 18.4006 APE9-dist-out 12.5547 None None None XRAY 2.8 0.214 0.28 A 383.0 352.0 0 25 25 0 [[24, 308]] 1.0 3dt1 CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4F9YA Q16539 5 353 360.0 LM3:403 Type1 Inactive DFGin 4.882 13.9136 BLBplus -102.45, 160.65 29.81, 64.99 -90.71, 149.15 35.58, 96.77 57.65, 21.07 in-in in 9.6237 Saltbr-in 3.0539 HRD-in -68.22, -54.55 80.29, -15.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 105.56 APE9-dihe-na -74.97, 136.74 APE8-dihe-out -59.26, -38.38 APE8-rot-in 286.11 APE67-dihe-in -60.96, -24.6 -57.6, -25.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.4839 APE9-dist-out 11.632 None None CME119,CME162 XRAY 1.85 0.169 0.2 A 383.0 339.0 10 25 15 10 [[24, 308]] 1.0 4f9y CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HL7A Q16539 6 352 360.0 I47:60401,I46:60402 Type1,Allosteric Inactive DFGin 5.2347 13.6446 BLBplus -124.2, 170.0 68.57, 19.0 -68.49, 146.41 46.64, 88.83 77.19, -0.15 in-in in 9.0409 Saltbr-in 2.4506 HRD-in -63.1, -58.98 80.27, -17.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.78 APE8-dihe-out -66.44, -27.56 APE8-rot-none 999.0 APE67-dihe-in -57.86, -27.57 -47.26, -39.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5313 None None None XRAY 1.88 0.2 0.228 A 360.0 336.0 11 25 14 11 [[24, 308]] 1.0 3hl7 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ROCA Q16539 5 352 360.0 29A:401,29B:402 Type1,Allosteric Inactive DFGin 4.9964 13.6824 BLBplus -116.4, 161.83 65.66, 26.8 -75.68, 149.71 49.46, 88.61 59.74, 17.57 in-out in 9.1566 Saltbr-out 3.8177 HRD-in -68.7, -52.88 78.63, -20.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 77.39 APE9-dihe-na -67.53, 134.61 APE8-dihe-out -65.0, -31.29 APE8-rot-none 999.0 APE67-dihe-in -56.87, -28.57 -61.2, -29.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.6616 APE9-dist-out 11.8193 None None None XRAY 1.7 0.348 0.276 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3roc CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HLLA Q16539 5 352 360.0 I45:60401,I46:60402,PO2:60501 Type1,Allosteric,Allosteric Inactive DFGin 5.053 13.5716 BLBplus -104.99, 158.54 67.03, 24.11 -71.37, 152.95 45.58, 87.31 67.6, 1.84 in-out in 9.1864 Saltbr-out 3.9688 HRD-in -64.7, -58.11 82.94, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -18.34 APE9-dihe-na -77.72, 94.48 APE8-dihe-out -49.19, -31.53 APE8-rot-none 999.0 APE67-dihe-in -66.1, -25.14 -64.45, -21.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.8147 APE9-dist-out 11.6667 None None None XRAY 1.95 0.219 0.254 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3hll CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2I0HA Q16539 4 352 360.0 222:400,222:3400 Type1,Type1 Inactive DFGin 4.6526 13.7145 BLBplus -106.37, 160.45 62.42, 22.28 -65.18, 141.95 38.84, 88.65 71.92, -3.35 in-in in 9.2912 Saltbr-in 2.6046 HRD-in -66.5, -53.14 79.92, -16.34 in-out-out SNCioo out-out ActLoopNT-out 10.2101 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -130.31, 137.86 APE9-dihe-na -63.58, -15.33 APE8-dihe-out -67.32, -21.26 APE8-rot-out 51.33 APE67-dihe-in -56.99, -26.01 -113.04, -22.46 APE12-dist-out 21.571 APE11-dist-out 23.4025 APE10-dist-out 17.6568 APE9-dist-out 11.7358 C162S None None XRAY 2.0 0.18 0.228 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 2i0h CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2RG5A Q16539 4 351 360.0 279:501 Type1.5_Back Inactive DFGin 5.3583 14.3061 BLBplus -115.64, 149.29 66.69, 28.57 -75.01, 151.54 46.26, 92.22 68.04, 7.04 in-in in 9.3341 Saltbr-in 2.9051 HRD-in -70.53, -62.91 89.6, -20.1 in-out-out SNCioo out-out ActLoopNT-out 6.4192 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 50.44 APE8-rot-out 58.38 APE67-dihe-in -62.43, -9.83 -150.6, -16.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.24 0.305 A 366.0 333.0 15 25 14 11 [[24, 308]] 1.0 2rg5 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3BX5A Q16539 5 352 360.0 304:501 Type1.5_Back Inactive DFGin 4.9015 13.3702 BLBplus -125.09, 165.17 58.72, 24.42 -71.11, 153.49 43.25, 78.29 58.15, 20.72 in-in in 8.9579 Saltbr-in 2.6694 HRD-in -67.15, -55.19 83.68, -26.42 in-out-none SNCion out-none ActLoopNT-out 8.2522 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.07 APE8-rot-in 330.74 APE67-dihe-in -57.19, -30.02 -67.98, -18.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.229 0.32 A 366.0 338.0 10 25 15 10 [[24, 308]] 1.0 3bx5 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3L8XA Q16539 4 352 360.0 N4D:361 Type1.5_Back Inactive DFGin 5.4768 13.7649 BLBplus -103.89, 151.97 54.08, 30.21 -68.52, 159.03 49.48, 84.71 59.15, 8.69 in-in in 8.9718 Saltbr-in 2.526 HRD-in -65.63, -40.87 63.88, -26.37 in-out-out SNCioo out-out ActLoopNT-out 9.0649 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -50.97 APE8-dihe-out -101.68, -30.89 APE8-rot-out 180.95 APE67-dihe-in -30.48, -35.23 -55.83, -28.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5884 None None None XRAY 2.4 0.225 0.319 A 366.0 326.0 23 25 15 10 [[24, 308]] 1.0 3l8x CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2RG6A Q16539 4 352 360.0 287:501,287:502 Type1.5_Back,Allosteric Inactive DFGin 5.1901 14.4166 BLBplus -115.84, 160.49 63.44, 25.5 -76.4, 154.46 53.74, 93.4 66.11, 10.49 in-in in 9.198 Saltbr-in 2.689 HRD-in -75.72, -61.01 84.35, -16.16 in-out-out SNCioo out-out ActLoopNT-out 7.584 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.76 APE8-dihe-out -57.98, -37.66 APE8-rot-out 59.87 APE67-dihe-in -66.56, -22.22 -53.28, -37.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.039 None None None XRAY 1.72 0.2 0.221 A 366.0 335.0 14 25 15 10 [[24, 308]] 1.0 2rg6 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4E6AA Q16539 4 351 360.0 0O9:500 Allosteric Inactive DFGin 7.8292 16.7355 None -116.35, 173.04 63.5, -177.46 -171.04, 999.0 277.86, 82.56 999.0, 999.0 in-in in 9.4716 Saltbr-in 2.9275 HRD-in -64.73, -56.61 86.56, -18.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.14, -22.79 999.0, 21.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.224 0.273 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e6a CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4E6CA Q16539 4 351 360.0 0O8:500 Allosteric Inactive DFGin 7.12 15.5419 None -107.87, 169.94 71.07, 48.65 -62.86, 999.0 316.7, 83.95 999.0, 999.0 in-in in 9.053 Saltbr-in 3.1301 HRD-in -64.38, -54.16 91.01, -29.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.63 APE8-rot-out 211.4 APE67-dihe-in -58.37, -26.81 -122.63, 18.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.22 0.292 A 360.0 330.0 18 25 10 15 [[24, 308]] 1.0 4e6c CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5N67A Q16539 5 353 360.0 8ON:401 Allosteric Inactive DFGin 6.8653 15.6092 None -128.23, -179.23 57.11, 61.45 -58.51, 999.0 306.28, 87.84 999.0, 999.0 in-in in 9.4444 Saltbr-in 3.0167 HRD-in -67.68, -53.37 80.76, -14.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.97 APE8-dihe-out -66.09, -43.78 APE8-rot-in 291.76 APE67-dihe-in -63.81, -23.7 -63.35, -24.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7672 None None None XRAY 1.9 0.191 0.222 A 360.0 327.0 22 25 11 14 [[24, 308]] 1.0 5n67 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 8X3MA Q16539 4 353 360.0 B8Z:401 Allosteric Inactive DFGin 7.7119 16.8556 None -115.94, 168.03 71.62, -88.99 88.0, 131.81 286.06, 88.99 -70.61, 105.76 in-in in 9.6027 Saltbr-in 3.0578 HRD-in -66.17, -53.58 79.95, -8.82 in-out-out SNCioo out-out ActLoopNT-out 10.5579 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.62, 133.04 APE9-dihe-na -62.46, -10.4 APE8-dihe-out -67.81, -17.48 APE8-rot-out 51.83 APE67-dihe-in -60.97, -25.8 -116.4, -18.75 APE12-dist-out 22.0398 APE11-dist-out 24.1061 APE10-dist-out 18.4386 APE9-dist-out 11.7912 None None None XRAY 1.85 0.183 0.226 A 365.0 350.0 0 25 25 0 [[24, 308]] 1.0 8x3m CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4DLIA Q16539 5 354 360.0 IRG:401,IRG:402 Allosteric,Allosteric Inactive DFGin 9.8147 11.8562 None -104.36, 150.39 -73.0, -47.15 -137.92, 126.59 314.79, 100.08 -44.68, 999.0 in-in in 9.4387 Saltbr-in 2.8448 HRD-in -68.95, -53.08 77.7, -11.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 123.1 APE9-dihe-na -70.95, 129.15 APE8-dihe-out -52.5, -43.49 APE8-rot-in 288.97 APE67-dihe-in -64.32, -23.54 -55.51, -29.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0955 None None None XRAY 1.91 0.216 0.255 A 360.0 334.0 16 25 13 12 [[24, 308]] 1.0 4dli CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH4A Q16539 4 354 360.0 IRG:401,0OL:402 Allosteric,Type1 Inactive DFGin 10.8466 12.1969 None -91.43, 145.17 -57.64, -47.01 -148.78, 133.96 289.87, 102.95 -106.02, 178.5 in-in in 9.3455 Saltbr-in 3.5333 HRD-in -75.34, -49.4 79.8, -22.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 89.91 APE9-dihe-na -88.64, 150.01 APE8-dihe-out -60.61, -41.02 APE8-rot-in 254.43 APE67-dihe-in -62.83, -20.65 -63.82, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.1023 APE9-dist-out 11.2223 None None None XRAY 2.5 0.234 0.317 A 360.0 337.0 14 25 15 10 [[24, 308]] 1.0 4eh4 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3C5UA Q16539 4 352 360.0 P41:361,P41:362 Allosteric,Type1 Inactive DFGin 5.9263 14.6107 None -79.99, -52.08 -111.86, 147.19 165.52, 164.69 70.95, 141.36 -178.3, -57.28 in-in in 9.4101 Saltbr-in 2.8949 HRD-in -58.08, -50.48 77.9, -18.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 89.15 APE9-dihe-na -79.53, 169.16 APE8-dihe-in -115.39, 178.62 APE8-rot-out 194.24 APE67-dihe-out 106.71, -27.43 -78.01, -142.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.0025 APE9-dist-out 13.5624 None None None XRAY 2.8 0.263 0.296 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 3c5u CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4E5AX Q16539 3 353 360.0 No_ligand No_ligand Inactive DFGin 7.4271 16.6777 None -111.06, 176.17 53.13, 71.95 -70.18, 999.0 294.84, 64.48 999.0, 999.0 in-in in 9.576 Saltbr-in 3.5066 HRD-in -71.06, -54.61 88.3, -21.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 105.51 APE8-dihe-in -65.33, 145.05 APE8-rot-out 181.03 APE67-dihe-in -68.36, -17.57 -107.7, 17.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7943 W197A None None XRAY 1.87 0.219 0.253 X 360.0 332.0 19 25 11 14 [[24, 308]] 1.0 4e5a CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3OD6X Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.1693 14.5472 None -107.32, -35.37 -122.54, 110.88 -101.89, 179.03 304.51, 65.36 116.69, -52.36 in-in in 9.7055 Saltbr-in 3.5749 HRD-out -70.82, 103.82 -92.19, 25.39 in-in-out SNCiio in-out ActLoopNT-in 2.9041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -86.05, 124.21 APE9-dihe-na 179.03, 165.34 APE8-dihe-in -50.68, 120.55 APE8-rot-in 316.14 APE67-dihe-in -54.18, -37.51 -81.72, -17.02 APE12-dist-in 10.2458 APE11-dist-out 6.7415 APE10-dist-out 9.7315 APE9-dist-out 7.1949 Y323T None None XRAY 2.682 0.215 0.283 X 360.0 344.0 5 25 25 0 [[24, 308]] 1.0 3od6 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3OEFX Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 4.9023 12.1341 None -108.05, 167.45 -157.07, -159.47 61.31, 35.4 325.61, 112.03 64.1, 24.95 in-in in 8.824 Saltbr-in 2.7137 HRD-in -68.42, -53.79 78.26, -14.32 in-out-none SNCion out-none ActLoopNT-out 17.9811 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.36 APE8-rot-in 260.2 APE67-dihe-in -60.02, -22.95 -112.04, 6.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y323F None None XRAY 1.6 0.187 0.221 X 360.0 334.0 14 25 14 11 [[24, 308]] 1.0 3oef CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ODYX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.2927 14.9518 None -99.56, -49.69 -113.79, 73.73 -150.67, 152.99 55.1, 98.03 53.69, 11.06 out-out out 11.8635 Saltbr-out 8.8242 HRD-out -75.99, 166.59 -145.03, -3.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 113.54 APE9-dihe-na -84.24, -15.35 APE8-dihe-out -79.73, -37.47 APE8-rot-in 312.81 APE67-dihe-in -57.52, -26.46 -53.29, -32.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9259 APE9-dist-out 11.0075 Y323Q None None XRAY 2.2 0.238 0.304 X 360.0 321.0 29 25 15 10 [[24, 308]] 1.0 3ody CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MGYA Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8489 15.4078 None -96.6, 163.16 144.18, -87.53 -41.62, 999.0 25.94, 59.9 999.0, 999.0 in-in in 9.8726 Saltbr-in 2.9683 HRD-in -64.11, -58.21 85.85, 0.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 165.22 APE8-rot-out 214.38 APE67-dihe-in -69.5, -24.6 -110.92, 8.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.243 0.291 A 360.0 329.0 19 25 10 15 [[24, 308]] 1.0 3mgy CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4E5BA Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGin 7.7496 16.4477 None -109.02, 158.46 31.08, 83.24 -71.5, 999.0 299.95, 31.84 999.0, 999.0 in-in in 9.2652 Saltbr-in 2.8145 HRD-in -56.8, -65.03 90.55, -13.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.6, -23.21 999.0, 23.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.237 0.279 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e5b CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ODZX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.0644 15.3431 None -127.95, -15.93 -113.67, 56.52 -144.01, 156.75 54.25, 120.62 60.75, 23.2 out-out out 11.618 Saltbr-out 9.0277 HRD-out -65.57, 130.15 -105.04, 19.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.07 APE9-dihe-na -94.07, 5.61 APE8-dihe-in -177.03, 113.52 APE8-rot-out 172.92 APE67-dihe-in -61.07, -28.1 -95.52, 3.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.3127 APE9-dist-out 12.5093 Y323R None None XRAY 2.3 0.223 0.282 X 360.0 335.0 15 25 15 10 [[24, 308]] 1.0 3odz CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5ETCA Q16539 1 352 360.0 No_ligand No_ligand Inactive DFGin 7.9268 17.5065 None -109.69, 177.11 57.89, 82.77 -103.25, -87.08 272.53, 90.11 -31.01, -89.71 in-out in 9.7017 Saltbr-out 3.6009 HRD-in -68.38, -45.82 79.56, -12.49 out-out-out SNCooo out-out ActLoopNT-out 10.994 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -140.41, 139.5 APE9-dihe-na -66.28, -17.2 APE8-dihe-out -69.09, -9.59 APE8-rot-out 56.2 APE67-dihe-in -64.25, -22.37 -125.41, -16.44 APE12-dist-out 21.1759 APE11-dist-out 23.1029 APE10-dist-out 17.3278 APE9-dist-out 11.8982 None None None XRAY 2.422 0.197 0.242 A 363.0 352.0 0 25 25 0 [[24, 308]] 1.0 5etc CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WFCA Q16539 5 351 360.0 No_ligand No_ligand Inactive DFGin 7.6408 16.6525 None -118.35, 179.66 63.95, -92.6 123.2, 999.0 266.78, 80.69 999.0, 999.0 in-out in 9.5424 Saltbr-out 3.6831 HRD-in -80.8, -27.0 48.37, 14.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -129.45, 133.38 APE9-dihe-na -57.59, -22.46 APE8-dihe-out -57.94, -20.68 APE8-rot-out 53.19 APE67-dihe-in -65.99, -19.65 -113.55, -17.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7898 None None None XRAY 2.3 0.213 0.297 A 366.0 340.0 5 25 20 5 [[24, 308]] 1.0 1wfc CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MH0A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 8.4153 16.8838 None -94.37, 151.84 67.81, 17.94 -52.66, 126.59 999.0, 999.0 86.82, 1.89 in-in in 9.3128 Saltbr-in 2.9134 HRD-in -65.91, -50.91 79.65, -20.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.01 APE8-rot-out 35.18 APE67-dihe-in -59.42, -23.13 -101.48, 7.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169A None None XRAY 2.0 0.232 0.28 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3mh0 CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3IW6A Q16539 4 353 360.0 PP0:361 Type1 Inactive DFGin 10.6593 12.8022 None -107.45, 146.07 -62.15, -52.96 -135.84, 140.51 306.3, 96.66 -100.47, -175.96 in-in in 8.9094 Saltbr-in 2.7027 HRD-in -68.9, -58.44 84.06, -12.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 89.13 APE9-dihe-na -68.25, 143.74 APE8-dihe-out -81.14, -28.36 APE8-rot-out 119.31 APE67-dihe-in -61.88, -28.19 -54.39, -28.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.738 APE9-dist-out 12.6069 C119S,C162S,A172C,F327L None None XRAY 2.1 0.213 0.273 A 360.0 337.0 13 25 14 11 [[24, 308]] 1.0 3iw6 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3IW7A Q16539 4 352 360.0 IPK:361 Type1 Inactive DFGin 10.7835 12.9675 None -101.08, 142.65 -64.35, -57.15 -132.52, 130.32 305.61, 101.42 -90.75, 171.73 in-in in 9.027 Saltbr-in 3.0854 HRD-in -64.07, -57.02 86.6, -16.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.97 APE8-dihe-out -80.2, 2.17 APE8-rot-out 181.73 APE67-dihe-in -62.05, -22.02 -116.3, -9.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0592 C119S,C162S,A172C,F327L None None XRAY 2.4 0.203 0.282 A 360.0 335.0 14 25 13 12 [[24, 308]] 1.0 3iw7 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2BAQA Q16539 5 351 360.0 PQB:401 Type1 Inactive DFGin 10.3272 11.741 None -89.31, 142.2 -51.16, -47.94 -140.37, 153.62 295.29, 101.84 -84.84, -141.61 in-in in 8.4503 Saltbr-in 2.9936 HRD-in -54.23, -50.45 81.43, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -91.51, 119.1 APE9-dihe-na -74.33, 131.38 APE8-dihe-out -51.32, -39.83 APE8-rot-in 282.97 APE67-dihe-in -50.36, -10.98 -69.35, -26.54 APE12-dist-none 999.0 APE11-dist-in 10.1777 APE10-dist-out 10.48 APE9-dist-out 11.6645 V30I None CSS162 XRAY 2.8 0.222 0.296 A 365.0 330.0 17 25 16 9 [[24, 308]] 1.0 2baq CMGC_MAPK14_HUMAN CMGC 4e-85 291.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WBOA Q16539 4 354 360.0 2CH:1355 Type1 Inactive DFGin 7.5035 16.9555 None -102.06, -162.61 -36.66, 129.23 -76.33, 147.94 286.93, 61.58 -66.99, 104.73 in-in in 9.724 Saltbr-in 2.7727 HRD-in -73.99, -52.37 82.98, -14.31 in-out-out SNCioo out-out ActLoopNT-out 10.5915 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.64, 132.01 APE9-dihe-na -58.44, -25.39 APE8-dihe-out -53.56, -33.51 APE8-rot-out 45.91 APE67-dihe-in -69.56, -19.55 -106.13, -10.44 APE12-dist-out 21.7087 APE11-dist-out 23.849 APE10-dist-out 18.1619 APE9-dist-out 11.712 None None None XRAY 2.16 0.167 0.22 A 360.0 351.0 0 25 25 0 [[24, 308]] 1.0 1wbo CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5OMGA Q16539 4 353 360.0 9Y8:402 Type1 Inactive DFGin 10.9259 12.75 None -99.59, 155.64 -73.45, -50.39 -143.59, 137.7 303.2, 98.46 -92.47, -157.32 in-in in 9.0658 Saltbr-in 3.1972 HRD-in -65.81, -53.84 75.16, -16.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 84.11 APE9-dihe-na -56.7, 137.85 APE8-dihe-out -66.22, -35.89 APE8-rot-out 184.11 APE67-dihe-in -59.63, -25.96 -58.79, -27.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.0608 APE9-dist-out 11.9487 None None None XRAY 2.0 0.186 0.245 A 360.0 337.0 13 25 15 10 [[24, 308]] 1.0 5omg CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9YTYA Q16539 4 353 360.0 A1BB6:402 Type1 Inactive DFGin 4.6111 13.1622 None -120.16, 162.46 56.72, 51.46 -84.98, 999.0 26.65, 85.72 999.0, 999.0 in-in in 9.4594 Saltbr-in 2.8615 HRD-in -70.78, -49.19 75.68, -17.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.8 APE8-dihe-out -66.34, -34.75 APE8-rot-in 298.99 APE67-dihe-in -64.81, -21.23 -60.57, -20.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7554 None None None XRAY 2.25 0.211 0.254 A 360.0 336.0 14 25 11 14 [[24, 308]] 1.0 9yty CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.8012 12.5528 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.5549 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.8014 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.7622 APE9-dist-out 12.6517 None None None XRAY 2.0 0.234 0.278 A 360.0 345.0 6 25 19 6 [[24, 308]] 1.0 3qud CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.6415 12.3386 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.9604 Saltbr-in 2.6567 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.2792 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1952 APE9-dist-out 11.3927 None None None XRAY 2.7 0.23 0.311 A 360.0 343.0 6 25 19 6 [[24, 308]] 1.0 3que CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ZSIA Q16539 6 352 360.0 52P:1000 Type1 Inactive DFGin 10.4689 12.2756 None -99.24, 157.46 -83.12, -44.9 -141.74, 118.5 319.2, 96.5 -93.21, -169.85 in-in in 8.8878 Saltbr-in 3.0614 HRD-in -68.1, -49.59 77.07, -12.99 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.82 APE8-rot-in 291.48 APE67-dihe-in -55.25, -30.12 -56.65, -32.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.234 0.271 A 362.0 326.0 21 25 12 13 [[24, 308]] 1.0 3zsi CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9MHBA Q16539 4 353 360.0 A1BLA:401 Type1 Inactive DFGin 7.102 16.2712 None -117.98, 165.25 51.74, 50.71 -38.59, 999.0 301.84, 11.59 999.0, 999.0 in-in in 9.4983 Saltbr-in 2.8857 HRD-in -70.02, -56.7 79.98, -12.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -51.26 APE9-dihe-na -76.26, 128.02 APE8-dihe-out -60.23, -38.8 APE8-rot-in 294.53 APE67-dihe-in -63.02, -23.59 -57.69, -25.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5631 None None CME162 XRAY 1.65 0.174 0.202 A 362.0 337.0 13 25 12 13 [[24, 308]] 1.0 9mhb CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FC1X Q16539 5 353 360.0 52P:362 Type1 Inactive DFGin 7.1239 15.1868 None -126.14, -173.97 53.21, -144.46 158.6, 119.78 279.97, 109.61 999.0, 999.0 in-in in 9.0296 Saltbr-in 2.6197 HRD-in -59.7, -53.23 81.3, -16.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -128.32, 135.87 APE9-dihe-na -60.12, -21.5 APE8-dihe-out -62.23, -25.4 APE8-rot-out 50.45 APE67-dihe-in -63.14, -19.02 -109.22, -16.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2558 None None None XRAY 2.4 0.204 0.251 X 366.0 334.0 13 25 17 8 [[24, 308]] 1.0 3fc1 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3BV2A Q16539 5 351 360.0 P38:501 Type1 Inactive DFGin 10.9192 11.9511 None -130.49, -172.23 -144.15, 148.34 64.11, 33.68 315.43, 116.87 -55.63, 125.6 in-in in 9.1734 Saltbr-in 2.72 HRD-in -59.8, -67.17 84.25, -8.03 in-out-out SNCioo out-out ActLoopNT-out 21.9505 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.36 APE8-dihe-out -57.65, -17.83 APE8-rot-out 225.25 APE67-dihe-in -64.72, -27.84 -71.88, -20.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1463 None None None XRAY 2.4 0.209 0.263 A 366.0 337.0 10 25 15 10 [[24, 308]] 1.0 3bv2 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3OCGA Q16539 4 352 360.0 OCG:361 Type1 Inactive DFGin 5.2198 14.3908 None -93.64, -75.59 -102.1, 63.24 -58.64, -80.69 42.2, 96.84 -84.43, 26.24 in-in in 9.0686 Saltbr-in 2.6197 HRD-in -63.56, -51.33 77.03, -20.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 103.73 APE8-rot-out 176.87 APE67-dihe-in -64.6, -19.08 -164.89, -32.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.214 0.27 A 366.0 336.0 13 25 12 13 [[24, 308]] 1.0 3ocg CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2GFSA Q16539 5 352 360.0 PQB:361 Type1 Inactive DFGin 7.4894 16.1685 None -132.16, -175.45 50.97, 60.34 -61.94, 999.0 284.15, 70.88 999.0, 999.0 in-in in 9.1388 Saltbr-in 2.7264 HRD-in -67.49, -53.73 80.94, -11.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.15, 132.57 APE9-dihe-na -61.35, -21.8 APE8-dihe-out -55.56, -23.97 APE8-rot-out 51.68 APE67-dihe-in -64.89, -19.57 -114.73, -17.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0158 None None None XRAY 1.752 0.206 0.239 A 372.0 344.0 4 25 21 4 [[24, 308]] 1.0 2gfs CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FMLA Q16539 4 352 360.0 FML:361 Type1 Inactive DFGin 7.3213 16.1677 None -113.5, 169.93 78.68, -95.68 95.06, 999.0 286.66, 90.12 999.0, 999.0 in-in in 9.4074 Saltbr-in 2.6446 HRD-in -67.48, -49.5 80.29, -18.01 in-out-out SNCioo out-out ActLoopNT-out 10.2813 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.68, 134.28 APE9-dihe-na -62.37, -13.16 APE8-dihe-out -68.44, -18.97 APE8-rot-out 59.25 APE67-dihe-in -63.75, -24.61 -116.53, -16.96 APE12-dist-out 21.7069 APE11-dist-out 23.7308 APE10-dist-out 17.9821 APE9-dist-out 11.9013 None None None XRAY 2.1 0.216 0.245 A 372.0 342.0 7 25 24 1 [[24, 308]] 1.0 3fml CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3FSKA Q16539 5 352 360.0 RO6:450 Type1 Inactive DFGin 7.5793 16.3094 None -136.71, -175.6 44.08, 65.21 -58.68, 999.0 291.46, 58.68 999.0, 999.0 in-in in 9.2711 Saltbr-in 2.5853 HRD-in -71.16, -52.26 76.45, -12.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.29, 134.45 APE9-dihe-na -62.73, -15.05 APE8-dihe-out -64.93, -17.06 APE8-rot-out 49.49 APE67-dihe-in -61.37, -23.14 -117.2, -17.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9695 None None None XRAY 2.0 0.207 0.243 A 372.0 342.0 6 25 19 6 [[24, 308]] 1.0 3fsk CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HA8A Q16539 4 352 360.0 5JZ:361 Type1 Inactive DFGin 7.6116 16.3381 None -141.16, 163.83 56.43, 72.99 -75.34, 999.0 309.72, 73.83 999.0, 999.0 in-out in 9.8651 Saltbr-out 4.0704 HRD-in -63.56, -51.44 79.66, -26.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -132.89, 139.9 APE9-dihe-na -58.34, -25.0 APE8-dihe-out -56.24, -14.15 APE8-rot-out 54.17 APE67-dihe-in -68.66, -11.09 -127.46, -12.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1308 None None None XRAY 2.48 0.217 0.248 A 379.0 342.0 7 25 18 7 [[24, 308]] 1.0 3ha8 CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4F9WA Q16539 5 352 360.0 LM4:403 Type1 Inactive DFGin 7.7255 16.584 None -80.52, 176.23 -63.07, 104.95 -100.59, 2.82 54.46, 75.64 130.88, -79.74 in-out in 9.4539 Saltbr-out 4.5982 HRD-in -68.07, -55.53 83.11, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.42 APE8-dihe-out -55.74, -38.36 APE8-rot-in 282.33 APE67-dihe-in -59.63, -26.4 -42.98, -44.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3918 None None None XRAY 2.0 0.173 0.216 A 383.0 336.0 12 25 13 12 [[24, 308]] 1.0 4f9w CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4FA2A Q16539 4 353 360.0 SB0:402 Type1 Inactive DFGin 8.1265 13.3665 None -98.53, 119.73 -70.7, -31.65 -138.38, 143.95 311.3, 93.7 107.84, 75.14 in-in in 9.0918 Saltbr-in 2.481 HRD-in -68.79, -53.09 81.55, -18.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -80.2 APE9-dihe-na -62.71, 131.19 APE8-dihe-out -61.7, -39.74 APE8-rot-in 283.35 APE67-dihe-in -60.81, -26.39 -57.15, -28.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1525 APE9-dist-out 11.2807 None None None XRAY 2.0 0.174 0.215 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4fa2 CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4ZTHA Q16539 4 353 360.0 VVT:401 Type1 Inactive DFGin 8.3008 13.855 None -89.83, 123.18 -77.72, -39.39 -125.61, 120.62 298.26, 98.01 -83.63, -144.08 in-in in 9.2036 Saltbr-in 2.9023 HRD-in -71.36, -49.73 75.36, -10.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -91.32 APE9-dihe-na -69.69, 130.87 APE8-dihe-out -61.18, -39.46 APE8-rot-in 289.92 APE67-dihe-in -57.67, -28.49 -59.49, -25.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5913 APE9-dist-out 11.6954 None None None XRAY 2.15 0.184 0.24 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4zth CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9O4LA Q16539 5 353 360.0 A1B8B:402 Type1 Inactive DFGin 5.0897 15.55 None -133.08, 171.57 61.65, 21.84 -73.72, 999.0 76.92, 114.61 999.0, 999.0 in-in in 9.488 Saltbr-in 2.7441 HRD-in -65.15, -53.31 77.94, -18.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.35 APE8-rot-in 324.94 APE67-dihe-out -67.13, -12.17 -110.61, 107.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.193 0.241 A 384.0 334.0 15 25 10 15 [[24, 308]] 1.0 9o4l CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3O8PA Q16539 5 351 360.0 BMU:361 Type1 Inactive DFGin 10.8634 12.0139 None -115.52, 162.58 -99.08, -26.53 -122.71, 117.21 291.85, 138.97 -42.63, -102.67 in-out in 9.092 Saltbr-out 5.0854 HRD-in -69.17, -52.21 73.92, -4.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 3.16 APE9-dihe-na -166.83, -167.55 APE8-dihe-out -116.39, -25.53 APE8-rot-in 271.29 APE67-dihe-in -61.81, -26.71 -69.76, -21.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1587 APE9-dist-out 10.4529 D168G None None XRAY 2.1 0.218 0.276 A 360.0 336.0 11 25 14 11 [[24, 308]] 1.0 3o8p CMGC_MAPK14_HUMAN CMGC 2.7e-83 285.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3OBGA Q16539 5 352 360.0 SB2:361 Type1 Inactive DFGin 8.5471 15.5472 None -95.25, 144.72 58.8, 33.65 -69.14, 75.21 999.0, 999.0 119.93, 18.42 in-in in 9.1521 Saltbr-in 2.4857 HRD-in -65.99, -57.89 82.28, -14.21 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.23 APE8-rot-in 336.97 APE67-dihe-in -54.89, -27.15 -56.97, -19.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169G None None XRAY 2.8 0.222 0.323 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3obg CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9D75A Q16539 5 353 360.0 A1A2L:60401 Type1 Inactive DFGin 7.2315 15.7878 None -119.44, 171.6 35.49, 86.57 -63.81, 999.0 294.63, 49.65 -63.81, 999.0 in-in in 9.0602 Saltbr-in 2.5179 HRD-in -70.24, -56.4 84.64, -17.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -1.29 APE8-rot-out 180.89 APE67-dihe-out -73.6, -14.85 -63.9, 126.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.13 0.208 0.236 A 346.0 335.0 11 25 14 11 [[24, 308]] 1.0 9d75 CMGC_MAPK14_HUMAN CMGC 1e-79 273.9 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9D7NA Q16539 5 353 360.0 A1A2O:60401 Type1 Inactive DFGin 6.7111 15.4176 None -125.4, 169.42 35.27, 85.02 -62.1, 999.0 300.08, 66.43 -62.1, 999.0 in-in in 9.1287 Saltbr-in 2.51 HRD-in -66.23, -52.52 80.02, -15.24 in-out-none SNCion out-none ActLoopNT-out 6.9136 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.33, -14.88 999.0, 144.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.973 0.214 0.257 A 346.0 337.0 9 25 16 9 [[24, 308]] 1.0 9d7n CMGC_MAPK14_HUMAN CMGC 1.3e-79 273.6 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EWQA Q16539 5 353 360.0 MWL:402,MWL:403 Type1,Allosteric Inactive DFGin 5.0183 13.3955 None -118.78, 173.31 61.29, 10.97 -62.77, 999.0 41.58, 86.71 999.0, 999.0 in-in in 9.2208 Saltbr-in 2.7732 HRD-in -66.73, -55.27 77.04, -7.68 in-out-out SNCioo out-out ActLoopNT-out 7.2789 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -109.0, 120.47 APE9-dihe-na -53.91, -56.01 APE8-dihe-in -144.08, 143.87 APE8-rot-out 173.18 APE67-dihe-out -56.97, -22.68 -121.19, 104.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2577 None TPO180 TPO180 XRAY 2.1 0.182 0.229 A 383.0 347.0 2 25 23 2 [[24, 308]] 1.0 4ewq CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.9243 13.1341 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.5432 Saltbr-out 3.9084 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2638 None None CME162 XRAY 2.06 0.178 0.217 A 383.0 336.0 13 25 12 13 [[24, 308]] 1.0 4r3c CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9NYTA Q16539 5 353 360.0 A1B7S:402,F50:404 Type1,Allosteric Inactive DFGin 4.2601 13.0797 None -116.13, 155.51 78.56, -1.77 -37.34, 999.0 47.87, 84.48 999.0, 999.0 in-out in 9.5555 Saltbr-out 4.0805 HRD-in -71.88, -52.7 83.59, -21.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.66 APE8-dihe-out -70.34, -25.73 APE8-rot-out 87.71 APE67-dihe-in -59.45, -18.84 -59.85, -29.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5386 None None None XRAY 2.16 0.195 0.24 A 384.0 335.0 14 25 11 14 [[24, 308]] 1.0 9nyt CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HP2A Q16539 4 355 360.0 P36:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 10.3229 12.0791 None -88.89, 117.93 0.95, -90.69 -132.19, 144.91 307.84, 89.53 -100.53, 179.64 in-in in 8.9859 Saltbr-in 3.0157 HRD-in -62.69, -56.28 83.82, -16.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -83.28 APE9-dihe-na -69.46, 121.84 APE8-dihe-out -57.79, -33.94 APE8-rot-in 290.47 APE67-dihe-in -56.52, -29.08 -65.16, -23.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8086 APE9-dist-out 11.9697 None None None XRAY 2.15 0.208 0.252 A 360.0 341.0 11 25 14 11 [[24, 308]] 1.0 3hp2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HP5A Q16539 6 352 360.0 52P:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 6.4998 14.3567 None -122.62, 154.65 81.43, 43.95 -64.35, -69.27 340.23, 142.83 -47.68, 999.0 in-in in 8.692 Saltbr-in 3.0371 HRD-in -62.14, -57.25 84.4, -19.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, -175.23 APE9-dihe-na -178.51, 127.74 APE8-dihe-out -56.55, -39.12 APE8-rot-none 999.0 APE67-dihe-in -64.7, -27.21 -46.07, -42.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3903 None None None XRAY 2.3 0.217 0.262 A 360.0 330.0 17 25 13 12 [[24, 308]] 1.0 3hp5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH9A Q16539 5 354 360.0 IRG:401,0OQ:402 Allosteric,Type3 Inactive DFGinter 10.8996 6.2057 None -97.42, 159.57 -62.33, -60.46 -150.13, 147.17 64.11, 82.71 -78.55, 25.4 in-out in 9.4044 Saltbr-out 4.5758 HRD-in -71.05, -53.71 82.13, -21.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 115.29 APE9-dihe-na -99.26, 134.28 APE8-dihe-out -59.4, -32.47 APE8-rot-in 294.18 APE67-dihe-in -64.19, -25.37 -57.95, -25.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.356 APE9-dist-out 11.8242 None None None XRAY 2.1 0.232 0.28 A 360.0 334.0 16 25 14 11 [[24, 308]] 1.0 4eh9 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GCPA Q16539 4 352 360.0 SB2:361 Type1 Inactive DFGinter 10.4711 9.2596 None -117.37, 167.72 -120.22, 32.97 -153.57, 150.38 52.4, 89.27 -67.24, 116.69 in-in in 9.1609 Saltbr-in 2.9485 HRD-in -63.02, -55.34 82.04, -15.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 176.81 APE8-rot-out 58.62 APE67-dihe-in -63.93, -20.89 -120.85, 2.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.25 0.201 0.276 A 360.0 337.0 12 25 13 12 [[24, 308]] 1.0 3gcp CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5WJJA Q16539 5 352 360.0 AQY:501 Type1 Inactive DFGinter 10.1585 9.0618 None -113.52, 161.05 -110.02, 23.38 -151.72, 163.67 53.5, 90.99 -95.62, 149.45 in-in in 9.5657 Saltbr-in 3.4445 HRD-in -66.13, -48.01 74.38, -15.21 in-out-out SNCioo out-out ActLoopNT-out 22.9602 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.37 APE8-dihe-out -54.87, -43.06 APE8-rot-in 316.01 APE67-dihe-in -61.84, -23.7 -56.22, -24.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1448 None None None XRAY 1.6 0.202 0.237 A 365.0 338.0 10 25 19 6 [[24, 308]] 1.0 5wjj CMGC_MAPK14_HUMAN CMGC 8.5e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6ANLA Q16539 4 352 360.0 T75:401 Type1 Inactive DFGinter 8.7017 9.562 None -112.8, 165.91 -107.34, -21.64 -131.97, 3.35 36.97, 78.14 70.96, -173.34 in-in in 9.9313 Saltbr-in 3.5889 HRD-in -64.58, -50.49 75.67, -10.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.9 APE8-dihe-out -67.0, -31.89 APE8-rot-in 294.98 APE67-dihe-in -56.18, -24.82 -62.08, -27.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8771 C119S,C162S None None XRAY 2.0 0.209 0.263 A 365.0 338.0 11 25 14 11 [[24, 308]] 1.0 6anl CMGC_MAPK14_HUMAN CMGC 8.5e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5ML5A Q16539 5 352 360.0 1VI:404 Type1 Inactive DFGinter 10.1363 9.2417 None -111.39, 159.42 -109.35, 34.77 -164.27, 172.15 56.08, 84.45 -90.56, 999.0 in-in in 9.3334 Saltbr-in 2.606 HRD-in -70.95, -52.33 83.04, -10.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.66 APE8-rot-in 289.06 APE67-dihe-in -53.62, -25.52 -105.11, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 A 360.0 326.0 22 25 11 14 [[24, 308]] 1.0 5ml5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HUCA Q16539 4 352 360.0 G97:362 Type1 Inactive DFGinter 10.3368 9.1786 None -109.97, 165.2 -105.06, 29.04 179.24, 164.7 62.51, 85.01 -109.68, 999.0 in-in in 9.5529 Saltbr-in 2.4424 HRD-in -73.07, -53.68 79.88, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 145.84 APE9-dihe-na -130.77, 137.71 APE8-dihe-out -61.1, -31.75 APE8-rot-in 284.73 APE67-dihe-in -65.27, -22.19 -58.7, -25.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1251 None None None XRAY 1.8 0.196 0.232 A 360.0 337.0 12 25 13 12 [[24, 308]] 1.0 3huc CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ZS5A Q16539 2 352 360.0 SB2:61000 Type1 Inactive DFGinter 10.2338 9.251 None -115.27, 172.44 -122.64, 34.9 -156.58, 162.56 53.94, 87.63 -91.34, 146.87 in-in in 9.4367 Saltbr-in 2.8264 HRD-in -66.65, -51.78 79.0, -9.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.47 APE8-dihe-out -65.94, -20.08 APE8-rot-out 57.11 APE67-dihe-in -60.59, -17.67 -110.97, -2.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4367 None None None XRAY 1.6 0.186 0.215 A 362.0 339.0 12 25 13 12 [[24, 308]] 1.0 3zs5 CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ZSGA Q16539 4 352 360.0 T75:400 Type1 Inactive DFGinter 9.8689 9.3824 None -112.39, 162.65 -112.67, 28.78 -156.41, 165.54 53.67, 85.81 -94.27, 155.51 in-in in 9.8169 Saltbr-in 3.4052 HRD-in -65.93, -52.33 82.35, -11.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -19.16 APE8-dihe-out -64.72, -27.97 APE8-rot-out 56.05 APE67-dihe-in -62.96, -19.39 -109.94, 3.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4087 None None None XRAY 1.89 0.191 0.233 A 362.0 337.0 12 25 13 12 [[24, 308]] 1.0 3zsg CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6HWTA Q16539 5 352 360.0 GXH:404 Type1 Inactive DFGinter 9.606 9.2491 None -109.85, 163.34 -111.83, 32.01 -158.93, 166.76 53.05, 86.7 -101.84, 157.19 in-in in 9.4049 Saltbr-in 3.1657 HRD-in -68.48, -52.76 78.69, -12.38 in-out-out SNCioo out-out ActLoopNT-out 23.1972 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.58 APE8-rot-out 199.92 APE67-dihe-in -66.05, -17.36 -114.13, 10.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.204 0.234 A 362.0 336.0 12 25 14 11 [[24, 308]] 1.0 6hwt CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6HWUA Q16539 5 353 360.0 GE5:404 Type1 Inactive DFGinter 9.5901 8.9682 None -118.08, 168.42 -117.72, 42.58 -170.41, 161.53 57.41, 87.05 -97.74, 161.01 in-in in 9.4576 Saltbr-in 2.9264 HRD-in -69.49, -51.73 75.06, -4.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 73.5 APE9-dihe-na -65.73, 137.2 APE8-dihe-out -60.1, -34.07 APE8-rot-in 274.51 APE67-dihe-in -66.54, -24.29 -62.93, -25.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2073 APE9-dist-out 11.5529 None None None XRAY 2.3 0.193 0.247 A 362.0 333.0 16 25 14 11 [[24, 308]] 1.0 6hwu CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6HWVA Q16539 5 352 360.0 GEW:404 Type1 Inactive DFGinter 9.9964 9.2856 None -112.84, 163.83 -110.3, 35.34 -165.77, 166.95 54.01, 85.28 -99.22, 157.29 in-in in 9.4943 Saltbr-in 2.8045 HRD-in -69.21, -52.62 80.0, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.66 APE8-rot-out 177.65 APE67-dihe-in -67.08, -18.22 -107.78, 6.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.18 0.197 A 362.0 336.0 12 25 13 12 [[24, 308]] 1.0 6hwv CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EHVA Q16539 5 352 360.0 0SJ:401,0SJ:402,IRG:403,0SJ:404 Type3,Allosteric,Allosteric,Allosteric Inactive DFGinter 10.9229 6.2755 None -99.66, 162.35 -69.64, -55.96 -152.93, 157.53 62.39, 91.72 -108.25, -179.88 in-none in 9.2374 Saltbr-none 999.0 HRD-in -69.34, -50.13 82.95, -13.29 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 107.52 APE9-dihe-na -78.18, 127.1 APE8-dihe-out -52.4, -41.18 APE8-rot-in 282.24 APE67-dihe-in -64.93, -23.91 -55.78, -30.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.946 APE9-dist-out 11.0047 None None None XRAY 1.6 0.223 0.252 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 4ehv CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9CJ3A Q16539 4 352 360.0 PDO:408,A1AWV:410 Allosteric,Type2 Inactive DFGout 15.2727 9.3064 BBAminus -138.7, -172.72 -146.54, 104.28 -50.46, -45.96 262.7, 81.94 68.22, 25.32 in-in in 8.4984 Saltbr-in 2.8294 HRD-in -69.96, -52.7 76.88, -14.52 in-out-out SNCioo out-out ActLoopNT-out 16.5343 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -126.47, 117.16 APE9-dihe-na -77.09, 129.32 APE8-dihe-out -52.48, -42.5 APE8-rot-in 292.76 APE67-dihe-in -62.21, -22.05 -58.1, -28.96 APE12-dist-out 14.7632 APE11-dist-in 12.8512 APE10-dist-out 12.7487 APE9-dist-out 10.3175 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.144 0.189 A 360.0 344.0 5 25 20 5 [[24, 308]] 1.0 9cj3 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6QDZA Q16539 5 352 360.0 I46:401,HYK:402 Allosteric,Type2 Inactive DFGout 14.9123 9.0812 BBAminus -134.77, -179.97 -142.81, 109.12 -72.73, -21.08 264.45, 91.98 63.26, 999.0 in-in in 8.4999 Saltbr-in 2.7579 HRD-in -75.35, -56.13 84.01, -14.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.14 APE8-dihe-out -58.44, -38.6 APE8-rot-in 261.35 APE67-dihe-in -64.54, -27.76 -61.68, -25.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4049 None None None XRAY 1.73 0.206 0.246 A 362.0 327.0 21 25 12 13 [[24, 308]] 1.0 6qdz CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6QE1A Q16539 5 352 360.0 I46:401,HYW:402 Allosteric,Type2 Inactive DFGout 14.5033 9.1773 BBAminus -141.03, -172.04 -146.99, 109.37 -71.94, -17.35 270.92, 90.33 65.73, 999.0 in-in in 8.7612 Saltbr-in 2.6233 HRD-in -65.85, -55.55 81.72, -12.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 126.37 APE8-dihe-out -53.58, -40.3 APE8-rot-in 269.79 APE67-dihe-in -62.76, -30.98 -60.8, -26.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3191 None None None XRAY 1.85 0.181 0.222 A 362.0 328.0 20 25 12 13 [[24, 308]] 1.0 6qe1 CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GCQA Q16539 4 355 360.0 1BU:401 Type2 Inactive DFGout 14.6646 10.6705 BBAminus -139.23, -170.27 -145.46, 100.56 -65.8, -17.82 263.24, 85.46 68.21, 999.0 in-out in 9.7205 Saltbr-out 5.0738 HRD-in -70.7, -53.82 76.41, -13.25 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 112.05 APE9-dihe-na -79.36, 140.98 APE8-dihe-out -65.6, -31.05 APE8-rot-in 287.72 APE67-dihe-in -59.4, -25.34 -65.07, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1048 C119S,C162S,A172C,F327L None None XRAY 2.0 0.219 0.27 A 360.0 337.0 15 25 13 12 [[24, 308]] 1.0 3gcq CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GCSA Q16539 5 352 360.0 BAX:401 Type2 Inactive DFGout 13.802 11.2196 BBAminus -148.91, -179.17 -135.91, 107.56 -69.03, -19.52 281.41, 117.73 85.38, 999.0 in-out in 9.7012 Saltbr-out 5.0624 HRD-in -66.45, -55.11 82.51, -13.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.89 APE8-rot-in 262.05 APE67-dihe-in -67.03, -18.78 -100.06, 9.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.1 0.204 0.262 A 360.0 331.0 17 25 11 14 [[24, 308]] 1.0 3gcs CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GCVA Q16539 4 353 360.0 SS6:361 Type2 Inactive DFGout 15.3653 12.0708 BBAminus -152.67, -170.82 -110.18, 113.34 -93.28, 22.0 252.44, 132.33 49.52, -127.32 in-in in 9.2779 Saltbr-in 2.6734 HRD-in -73.49, -50.16 80.46, -18.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.63 APE9-dihe-na -79.69, 139.68 APE8-dihe-out -61.27, -36.62 APE8-rot-in 278.06 APE67-dihe-in -71.87, -21.97 -66.32, -17.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.6551 APE9-dist-out 10.9984 C119S,C162S,A172C,F327L None None XRAY 2.3 0.199 0.254 A 360.0 338.0 12 25 15 10 [[24, 308]] 1.0 3gcv CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV3A Q16539 4 353 360.0 R49:361 Type2 Inactive DFGout 14.6691 10.0538 BBAminus -138.69, -175.75 -140.2, 99.87 -64.25, -13.35 254.6, 108.31 -167.95, 999.0 in-in in 9.4709 Saltbr-in 3.1771 HRD-in -71.8, -52.19 74.58, -14.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 117.52 APE9-dihe-na -88.84, 141.45 APE8-dihe-out -61.65, -30.9 APE8-rot-in 283.55 APE67-dihe-in -62.55, -24.37 -61.18, -30.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0565 C119S,C162S,A172C,F327L None None XRAY 2.0 0.233 0.3 A 360.0 335.0 15 25 13 12 [[24, 308]] 1.0 3hv3 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LFEA Q16539 4 353 360.0 Z84:361 Type2 Inactive DFGout 13.8532 10.6121 BBAminus -143.39, -175.95 -148.84, 101.16 -68.77, -23.71 286.29, 130.19 55.28, 999.0 in-in in 9.2081 Saltbr-in 2.9986 HRD-in -66.22, -52.7 79.44, -21.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.9 APE8-dihe-out -73.25, -29.21 APE8-rot-in 294.69 APE67-dihe-in -59.42, -21.9 -66.48, -18.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6744 C119S,C162S,A172C,F327L None None XRAY 2.3 0.217 0.274 A 360.0 334.0 16 25 12 13 [[24, 308]] 1.0 3lfe CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LFFA Q16539 5 352 360.0 Z83:362 Type2 Inactive DFGout 13.7444 9.2828 BBAminus -133.71, -177.31 -147.05, 100.37 -58.09, -30.94 280.16, 120.96 67.43, 999.0 in-in in 8.413 Saltbr-in 2.8332 HRD-in -66.74, -56.1 82.28, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.23 APE8-dihe-out -53.58, -33.4 APE8-rot-in 266.57 APE67-dihe-in -64.59, -22.45 -107.2, 0.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.9371 C119S,C162S,A172C,F327L None None XRAY 1.5 0.2 0.225 A 360.0 335.0 13 25 12 13 [[24, 308]] 1.0 3lff CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3PG3A Q16539 4 353 360.0 DG7:362 Type2 Inactive DFGout 13.0987 10.5554 BBAminus -137.98, -176.41 -143.4, 105.33 -78.6, -12.21 284.63, 130.22 62.45, 999.0 out-out out 10.0654 Saltbr-out 4.9546 HRD-in -65.37, -57.04 80.78, -17.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.31 APE8-dihe-out -77.9, -6.45 APE8-rot-out 68.06 APE67-dihe-in -64.35, -20.06 -105.87, -4.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1627 C119S,C162S,A172C,F327L None None XRAY 2.0 0.221 0.261 A 360.0 337.0 13 25 12 13 [[24, 308]] 1.0 3pg3 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6SFIA Q16539 4 353 360.0 LB5:401 Type2 Inactive DFGout 13.3937 10.6179 BBAminus -129.5, -179.89 -143.16, 112.38 -90.24, 3.11 298.38, 125.14 -102.41, -164.82 in-in in 9.1561 Saltbr-in 2.8191 HRD-in -70.1, -55.69 77.65, -7.32 in-out-out SNCioo out-out ActLoopNT-out 6.0401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -68.49 APE8-dihe-in -119.24, 141.74 APE8-rot-out 178.05 APE67-dihe-in -68.18, -20.08 -104.43, 11.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4088 None None None XRAY 1.6 0.176 0.203 A 361.0 340.0 10 25 15 10 [[24, 308]] 1.0 6sfi CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6SFJA Q16539 4 353 360.0 LBB:401 Type2 Inactive DFGout 13.7245 10.6811 BBAminus -123.13, 178.73 -142.95, 116.4 -91.09, 8.2 302.11, 122.57 58.02, -143.48 in-in in 9.057 Saltbr-in 2.7594 HRD-in -65.53, -58.09 80.46, -16.37 in-out-out SNCioo out-out ActLoopNT-out 19.1753 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 102.4 APE9-dihe-na -70.83, 128.75 APE8-dihe-out -52.3, -41.24 APE8-rot-in 279.44 APE67-dihe-in -65.41, -19.81 -40.73, -45.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.683 APE9-dist-out 11.0277 None None None XRAY 1.95 0.187 0.227 A 361.0 341.0 9 25 16 9 [[24, 308]] 1.0 6sfj CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6SFOA Q16539 5 352 360.0 LBE:402 Type2 Inactive DFGout 13.107 10.3486 BBAminus -133.23, 176.29 -141.54, 104.3 -74.14, -17.59 288.97, 121.95 -93.86, 999.0 in-in in 9.2345 Saltbr-in 2.8873 HRD-in -66.53, -57.57 78.56, -10.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 77.52 APE9-dihe-na -59.94, 128.18 APE8-dihe-out -53.66, -40.71 APE8-rot-in 281.51 APE67-dihe-in -59.09, -32.81 -60.23, -32.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9439 None None None XRAY 1.75 0.193 0.236 A 361.0 334.0 14 25 13 12 [[24, 308]] 1.0 6sfo CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6ZWPA Q16539 4 353 360.0 OE8:401 Type2 Inactive DFGout 13.1697 10.4903 BBAminus -143.26, -177.15 -138.64, 100.63 -74.29, -17.88 287.51, 117.46 71.05, 999.0 in-in in 9.0912 Saltbr-in 2.6302 HRD-in -68.6, -58.63 80.97, -13.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -90.87 APE9-dihe-na -64.71, 121.83 APE8-dihe-out -50.5, -42.84 APE8-rot-in 294.97 APE67-dihe-in -56.58, -32.08 -60.33, -32.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6461 None None None XRAY 1.9 0.215 0.251 A 361.0 328.0 22 25 13 12 [[24, 308]] 1.0 6zwp CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3CTQA Q16539 5 352 360.0 337:1 Type2 Inactive DFGout 14.2256 10.9769 BBAminus -131.82, -176.84 -153.58, 135.58 -106.9, 11.33 302.88, 150.47 51.03, 999.0 in-in in 9.0033 Saltbr-in 2.6384 HRD-in -63.28, -57.42 77.14, -7.58 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 125.24 APE9-dihe-na -79.17, 136.28 APE8-dihe-out -57.02, -39.72 APE8-rot-out 76.68 APE67-dihe-in -53.14, -28.61 -51.51, -43.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7603 None None None XRAY 1.95 0.23 0.269 A 348.0 336.0 12 25 13 12 [[24, 308]] 1.0 3ctq CMGC_MAPK14_HUMAN CMGC 3.8e-85 291.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5MZ3A Q16539 4 353 360.0 8EN:401 Type2 Inactive DFGout 12.3243 10.0727 BBAminus -138.69, -176.72 -144.33, 92.3 -89.87, 8.58 281.81, 11.32 -64.84, 131.14 in-in in 9.3713 Saltbr-in 2.7278 HRD-in -65.21, -54.32 77.27, -16.15 in-out-out SNCioo out-out ActLoopNT-out 15.7602 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.22, 136.32 APE9-dihe-na -62.44, -24.76 APE8-dihe-out -59.5, -22.25 APE8-rot-out 57.3 APE67-dihe-in -63.85, -25.43 -113.93, -15.51 APE12-dist-out 19.8351 APE11-dist-out 21.014 APE10-dist-out 15.3944 APE9-dist-out 11.5273 C162S None None XRAY 2.15 0.166 0.197 A 369.0 350.0 0 25 25 0 [[24, 308]] 1.0 5mz3 CMGC_MAPK14_HUMAN CMGC 1.7e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HEGA Q16539 5 352 360.0 BAX:1 Type2 Inactive DFGout 13.9801 10.4162 BBAminus -138.78, -176.3 -143.83, 112.16 -66.98, -96.1 288.65, 119.82 123.84, 999.0 in-in in 9.6179 Saltbr-in 3.0077 HRD-in -67.99, -50.51 67.42, -7.32 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -161.71, 88.05 APE9-dihe-na -78.71, 132.75 APE8-dihe-out -59.19, -30.56 APE8-rot-in 282.81 APE67-dihe-in -52.86, -23.91 -65.83, -36.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8536 None None None XRAY 2.2 0.24 0.309 A 348.0 333.0 15 25 14 11 [[24, 308]] 1.0 3heg CMGC_MAPK14_HUMAN CMGC 5.2e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1W83A Q16539 4 355 360.0 L11:1355 Type2 Inactive DFGout 14.7052 11.6052 BBAminus -142.16, -178.02 -126.62, 107.98 -77.01, -19.08 266.9, 115.16 -50.83, 116.59 in-in in 9.0006 Saltbr-in 2.7053 HRD-in -57.58, -54.74 77.55, -14.6 in-out-out SNCioo out-out ActLoopNT-out 15.7211 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -123.36, 133.64 APE9-dihe-na -56.55, -24.42 APE8-dihe-out -67.3, -13.21 APE8-rot-out 68.23 APE67-dihe-in -60.67, -28.08 -119.99, -15.67 APE12-dist-out 20.2746 APE11-dist-out 21.3637 APE10-dist-out 15.7805 APE9-dist-out 11.7822 None None None XRAY 2.5 0.233 0.322 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w83 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WBNA Q16539 4 355 360.0 L09:1355 Type2 Inactive DFGout 14.7526 12.4497 BBAminus -144.68, -164.93 -135.23, 106.6 -72.63, -9.67 292.92, 86.74 -55.54, 132.36 in-in in 9.2626 Saltbr-in 3.053 HRD-in -70.35, -54.36 78.68, -15.66 in-out-out SNCioo out-out ActLoopNT-out 15.8194 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.23, 129.6 APE9-dihe-na -55.11, -23.17 APE8-dihe-out -56.32, -28.39 APE8-rot-out 52.74 APE67-dihe-in -64.32, -21.9 -108.48, -14.84 APE12-dist-out 20.3417 APE11-dist-out 21.4319 APE10-dist-out 15.9316 APE9-dist-out 11.7105 None None None XRAY 2.4 0.181 0.244 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbn CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3D83A Q16539 4 352 360.0 GK6:401 Type2 Inactive DFGout 14.6482 11.9189 BBAminus -137.19, -168.47 -140.74, 108.25 -84.28, -6.57 283.56, 93.12 -53.93, 125.26 in-in in 9.1168 Saltbr-in 2.6767 HRD-in -73.2, -53.34 72.61, -11.66 in-out-out SNCioo out-out ActLoopNT-out 15.2929 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.95, 133.17 APE9-dihe-na -61.38, -18.76 APE8-dihe-out -61.88, -18.27 APE8-rot-out 59.42 APE67-dihe-in -60.96, -22.43 -116.21, -20.51 APE12-dist-out 20.4469 APE11-dist-out 21.7569 APE10-dist-out 16.1089 APE9-dist-out 11.8046 None None CSO119,CSO162 XRAY 1.9 0.177 0.218 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 3d83 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9CJ4A Q16539 5 352 360.0 B96:401 Type2 Inactive DFGout 15.34 9.2502 BBAminus -140.85, -174.89 -146.31, 104.15 -52.61, -47.17 266.98, 78.45 63.05, 28.98 in-in in 8.7329 Saltbr-in 2.7511 HRD-in -68.26, -51.49 71.88, -11.93 in-out-out SNCioo out-out ActLoopNT-out 16.6629 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -132.6, 106.16 APE9-dihe-na -83.05, 127.8 APE8-dihe-out -48.48, -41.43 APE8-rot-in 291.57 APE67-dihe-in -63.37, -26.47 -62.41, -24.06 APE12-dist-out 16.029 APE11-dist-out 15.1827 APE10-dist-out 13.118 APE9-dist-out 10.6363 None TPO180,PTR182 TPO180,PTR182 XRAY 1.8 0.162 0.199 A 360.0 336.0 12 25 18 7 [[24, 308]] 1.0 9cj4 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GCUA Q16539 4 352 360.0 R48:401 Type2 Inactive DFGout 14.5429 11.8091 BBAminus -146.91, -162.95 -136.64, 100.46 -77.49, -11.4 270.17, 105.48 -56.49, 136.97 in-in in 8.9542 Saltbr-in 2.8868 HRD-in -67.23, -51.11 76.39, -20.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 102.53 APE9-dihe-na -59.15, 138.32 APE8-dihe-out -60.95, -36.87 APE8-rot-in 271.19 APE67-dihe-in -60.94, -27.8 -58.38, -29.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5825 APE9-dist-out 11.0643 None None None XRAY 2.1 0.19 0.235 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3gcu CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GCUB Q16539 5 352 360.0 R48:401 Type2 Inactive DFGout 14.7976 11.6309 BBAminus -128.97, -177.2 -130.82, 102.93 -76.01, -7.46 275.51, 99.04 -57.11, 134.5 in-in in 8.843 Saltbr-in 2.6741 HRD-in -69.2, -51.89 79.51, -18.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 90.91 APE9-dihe-na -82.69, 132.53 APE8-dihe-out -52.31, -42.31 APE8-rot-in 283.62 APE67-dihe-in -63.1, -25.88 -54.06, -31.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5094 APE9-dist-out 11.1021 None None None XRAY 2.1 0.19 0.235 B 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3gcu CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV4A Q16539 4 352 360.0 L51:361 Type2 Inactive DFGout 14.7347 11.6287 BBAminus -142.67, -157.85 -140.68, 86.15 -62.83, -22.45 270.53, 99.57 -47.3, 133.93 in-in in 8.8696 Saltbr-in 3.0093 HRD-in -66.37, -49.94 75.86, -15.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 47.43 APE9-dihe-na -51.5, 140.47 APE8-dihe-out -61.26, -39.48 APE8-rot-in 266.64 APE67-dihe-in -57.18, -30.17 -58.29, -24.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.842 APE9-dist-out 11.2826 None None None XRAY 2.6 0.197 0.271 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3hv4 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV4B Q16539 5 352 360.0 L51:361 Type2 Inactive DFGout 15.7924 12.0072 BBAminus -145.26, -175.16 -120.86, 83.83 -51.51, -19.7 265.81, 75.93 -56.18, 124.85 in-in in 8.8621 Saltbr-in 2.8135 HRD-in -65.01, -48.44 76.59, -19.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 74.36 APE9-dihe-na -74.32, 124.34 APE8-dihe-out -50.56, -46.12 APE8-rot-in 289.55 APE67-dihe-in -60.36, -22.87 -26.56, -50.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.0304 APE9-dist-out 11.2607 None None None XRAY 2.6 0.197 0.271 B 360.0 338.0 10 25 15 10 [[24, 308]] 1.0 3hv4 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV5A Q16539 4 352 360.0 R24:361 Type2 Inactive DFGout 14.524 11.8501 BBAminus -149.06, -161.59 -134.02, 95.31 -72.2, -13.6 276.5, 110.91 -63.01, 141.02 in-in in 8.8866 Saltbr-in 2.9262 HRD-in -71.92, -48.65 78.83, -18.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 70.02 APE9-dihe-na -69.23, 130.56 APE8-dihe-out -52.66, -36.6 APE8-rot-in 268.08 APE67-dihe-in -58.06, -29.94 -67.56, -24.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.5095 APE9-dist-out 11.1603 None None None XRAY 2.25 0.19 0.26 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3hv5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV5B Q16539 4 352 360.0 R24:361 Type2 Inactive DFGout 14.9875 11.9865 BBAminus -143.61, -171.37 -127.57, 96.09 -68.49, -17.63 274.9, 105.84 -67.24, 132.58 in-in in 8.7939 Saltbr-in 2.7692 HRD-in -68.01, -49.62 79.57, -9.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 94.22 APE9-dihe-na -73.49, 125.26 APE8-dihe-out -48.98, -52.43 APE8-rot-in 285.06 APE67-dihe-in -67.34, -20.49 -29.85, -42.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.9937 APE9-dist-out 11.0049 None None None XRAY 2.25 0.19 0.26 B 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3hv5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV6A Q16539 4 352 360.0 R39:361 Type2 Inactive DFGout 14.7079 9.1265 BBAminus -136.88, -171.81 -147.79, 102.81 -62.49, -26.59 256.35, 92.54 82.94, 999.0 in-out in 9.2791 Saltbr-out 5.2211 HRD-in -66.15, -59.41 84.5, -16.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 105.05 APE9-dihe-na -67.09, 136.12 APE8-dihe-out -58.82, -42.73 APE8-rot-in 268.25 APE67-dihe-in -61.59, -24.03 -51.22, -33.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3016 None None None XRAY 1.95 0.21 0.254 A 360.0 331.0 18 25 13 12 [[24, 308]] 1.0 3hv6 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2BAKA Q16539 5 353 360.0 AQZ:401 Type2 Inactive DFGout 14.0717 11.4156 BBAminus -143.45, -169.82 -148.04, 89.96 -71.5, -10.34 301.49, 112.56 74.77, 999.0 in-in in 9.3031 Saltbr-in 2.7314 HRD-in -70.02, -52.87 74.17, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 100.58 APE9-dihe-na -65.01, 135.39 APE8-dihe-out -56.44, -41.69 APE8-rot-in 273.92 APE67-dihe-in -57.73, -27.0 -56.68, -27.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1896 None None None XRAY 2.2 0.22 0.25 A 365.0 334.0 15 25 13 12 [[24, 308]] 1.0 2bak CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4A9YA Q16539 5 353 360.0 AQZ:1354 Type2 Inactive DFGout 14.0717 11.4156 BBAminus -143.45, -169.82 -148.04, 89.96 -71.5, -10.34 301.49, 112.96 74.77, 999.0 in-in in 9.3031 Saltbr-in 2.7314 HRD-in -70.02, -52.87 74.17, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 100.58 APE9-dihe-na -65.01, 135.39 APE8-dihe-out -56.44, -41.69 APE8-rot-in 273.92 APE67-dihe-in -57.73, -27.0 -56.68, -27.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1896 None None None XRAY 2.2 0.22 0.25 A 365.0 334.0 15 25 13 12 [[24, 308]] 1.0 4a9y CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4AA0A Q16539 5 352 360.0 AA0:1353 Type2 Inactive DFGout 14.6817 11.477 BBAminus -143.28, -166.01 -144.55, 110.59 -86.89, -1.57 289.14, 127.7 54.63, 999.0 in-in in 9.3194 Saltbr-in 2.617 HRD-in -66.16, -56.66 81.83, -14.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 119.24 APE9-dihe-na -72.72, 134.51 APE8-dihe-out -52.65, -40.98 APE8-rot-in 289.14 APE67-dihe-in -62.58, -23.78 -58.6, -28.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9569 None None None XRAY 1.8 0.213 0.255 A 365.0 329.0 19 25 13 12 [[24, 308]] 1.0 4aa0 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3E93A Q16539 4 353 360.0 19B:361 Type2 Inactive DFGout 14.038 11.4248 BBAminus -135.93, -177.11 -132.75, 104.83 -82.94, 5.62 292.66, 110.23 -52.26, 119.09 in-in in 9.0918 Saltbr-in 2.7093 HRD-in -67.09, -55.84 76.8, -18.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -143.6, 133.73 APE9-dihe-na -64.58, -15.28 APE8-dihe-out -65.21, -15.66 APE8-rot-out 52.25 APE67-dihe-in -60.51, -24.62 -117.51, -21.31 APE12-dist-out 19.7381 APE11-dist-out 21.101 APE10-dist-out 15.5016 APE9-dist-out 11.6946 None None CSO162 XRAY 2.0 0.171 0.228 A 371.0 347.0 3 25 22 3 [[24, 308]] 1.0 3e93 CMGC_MAPK14_HUMAN CMGC 6.5e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3KQ7A Q16539 5 352 360.0 KQ7:361 Type2 Inactive DFGout 14.1565 11.9477 BBAminus -131.22, -173.69 -137.41, 105.18 -78.86, -5.42 289.01, 106.12 -55.69, 128.77 in-in in 8.8894 Saltbr-in 2.7547 HRD-in -74.51, -54.27 77.08, -12.8 in-out-out SNCioo out-out ActLoopNT-out 16.3329 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.38, 132.2 APE9-dihe-na -60.0, -17.54 APE8-dihe-out -70.63, -8.61 APE8-rot-out 52.04 APE67-dihe-in -65.18, -21.16 -118.62, -19.11 APE12-dist-out 20.1698 APE11-dist-out 21.4841 APE10-dist-out 15.9258 APE9-dist-out 11.5399 None None None XRAY 1.8 0.19 0.233 A 380.0 348.0 0 25 25 0 [[24, 308]] 1.0 3kq7 CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3GI3A Q16539 5 352 360.0 B10:391 Type2 Inactive DFGout 15.003 9.7282 BBAminus -144.29, -176.79 -144.27, 112.55 -73.33, 53.52 274.48, 85.31 63.16, 999.0 in-in in 9.1348 Saltbr-in 3.4296 HRD-in -67.61, -56.78 77.91, -15.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 159.14 APE9-dihe-na -51.99, 118.6 APE8-dihe-out -61.48, -51.94 APE8-rot-out 77.45 APE67-dihe-in -60.43, -23.14 -53.99, -38.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5145 None None None XRAY 2.4 0.23 0.289 A 360.0 330.0 18 25 13 12 [[24, 308]] 1.0 3gi3 CMGC_MAPK14_HUMAN CMGC 1.7e-83 286.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3IW8A Q16539 4 352 360.0 HIZ:361 Type3 Inactive DFGout 14.3393 10.7484 BBAminus -128.77, 173.15 -144.49, 96.52 -69.13, -29.38 264.26, 95.46 -57.05, 999.0 in-in in 9.5835 Saltbr-in 3.1837 HRD-in -68.87, -52.0 80.48, -15.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.92 APE8-dihe-out -64.98, -16.01 APE8-rot-out 58.5 APE67-dihe-in -67.61, -18.84 -96.57, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.89 C119S,C162S,A172C,F327L None None XRAY 2.0 0.22 0.298 A 360.0 334.0 15 25 12 13 [[24, 308]] 1.0 3iw8 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LFBA Q16539 4 353 360.0 Z87:361 Type3 Inactive DFGout 13.5059 8.6694 BBAminus -137.91, -175.41 -148.69, 98.28 -75.6, 80.49 288.48, 128.29 -32.77, 999.0 in-in in 8.8689 Saltbr-in 3.3022 HRD-in -68.86, -47.3 79.01, -11.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 142.13 APE8-dihe-out -63.54, -31.96 APE8-rot-in 292.75 APE67-dihe-in -68.43, -9.24 -55.41, -18.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7626 C119S,C162S,A172C,F327L None None XRAY 2.6 0.236 0.32 A 360.0 333.0 17 25 12 13 [[24, 308]] 1.0 3lfb CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LFCA Q16539 4 354 360.0 Z86:361 Type3 Inactive DFGout 15.0835 10.4692 BBAminus -140.93, 172.03 -136.7, 104.03 -73.11, 19.87 257.43, 81.27 31.49, 999.0 in-in in 9.185 Saltbr-in 2.9144 HRD-in -68.27, -48.31 75.76, -5.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.38 APE8-dihe-out -70.67, -45.62 APE8-rot-in 307.9 APE67-dihe-in -82.24, -9.74 -64.34, 0.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7803 C119S,C162S,A172C,F327L None None XRAY 2.8 0.242 0.326 A 360.0 334.0 17 25 12 13 [[24, 308]] 1.0 3lfc CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3NNVA Q16539 5 352 360.0 437:355 Type3 Inactive DFGout 14.5716 9.2585 BBAminus -142.55, -173.27 -145.34, 106.59 -51.19, -52.47 263.96, 85.79 66.07, 29.58 in-in in 8.439 Saltbr-in 2.6549 HRD-in -68.73, -54.43 79.33, -18.5 in-out-out SNCioo out-out ActLoopNT-out 15.2643 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.26, 134.3 APE9-dihe-na -61.65, -19.68 APE8-dihe-out -63.7, -16.87 APE8-rot-out 57.56 APE67-dihe-in -65.56, -22.72 -113.46, -23.13 APE12-dist-out 19.8237 APE11-dist-out 21.1003 APE10-dist-out 15.4487 APE9-dist-out 11.7056 None None None XRAY 2.1 0.188 0.235 A 354.0 348.0 0 25 25 0 [[24, 308]] 1.0 3nnv CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3NNXA Q16539 5 352 360.0 EDD:355 Type3 Inactive DFGout 14.2 9.2163 BBAminus -135.6, -177.89 -139.59, 108.47 -57.96, -45.51 273.61, 91.9 59.97, 25.47 in-in in 8.607 Saltbr-in 2.8874 HRD-in -71.36, -53.19 82.69, -16.33 in-out-out SNCioo out-out ActLoopNT-out 17.2369 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -88.62, 104.06 APE9-dihe-na -72.31, 123.14 APE8-dihe-out -62.65, -30.04 APE8-rot-out 108.29 APE67-dihe-in -62.69, -25.91 -61.93, -24.39 APE12-dist-none 999.0 APE11-dist-in 12.9915 APE10-dist-out 12.8716 APE9-dist-out 10.6831 None PTR182 PTR182 XRAY 2.28 0.222 0.285 A 354.0 337.0 11 25 18 7 [[24, 308]] 1.0 3nnx CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1W82A Q16539 4 355 360.0 L10:1356 Type3 Inactive DFGout 14.0689 9.1738 BBAminus -147.9, -178.18 -145.43, 99.06 -49.9, -42.31 277.8, 103.87 66.12, 29.05 in-in in 8.9178 Saltbr-in 2.5493 HRD-in -69.25, -58.44 82.74, -19.28 in-out-out SNCioo out-out ActLoopNT-out 15.3244 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.24, 132.47 APE9-dihe-na -61.88, -19.44 APE8-dihe-out -63.75, -20.33 APE8-rot-out 53.66 APE67-dihe-in -64.33, -18.99 -112.97, -18.8 APE12-dist-out 19.6069 APE11-dist-out 20.9631 APE10-dist-out 15.2637 APE9-dist-out 11.814 None None None XRAY 2.2 0.174 0.235 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w82 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WBVA Q16539 4 355 360.0 LI3:1355 Type3 Inactive DFGout 13.8114 10.6204 BBAminus -134.67, -171.45 -143.3, 105.97 -79.38, -25.77 282.68, 115.07 -27.13, 80.56 in-in in 9.4434 Saltbr-in 2.6654 HRD-in -73.41, -55.51 76.97, -15.29 in-out-out SNCioo out-out ActLoopNT-out 15.6716 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -135.39, 133.7 APE9-dihe-na -61.21, -22.55 APE8-dihe-out -53.62, -26.32 APE8-rot-in 304.67 APE67-dihe-in -66.43, -19.77 -114.84, -13.62 APE12-dist-out 19.7295 APE11-dist-out 21.0278 APE10-dist-out 15.3447 APE9-dist-out 11.8668 None None None XRAY 2.0 0.18 0.233 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbv CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HV7A Q16539 5 352 360.0 1AU:361 Type3 Inactive DFGout 14.4625 9.1323 BBAminus -135.81, -172.79 -148.84, 101.39 -62.36, -41.87 280.67, 103.39 51.74, 88.53 in-in in 8.8667 Saltbr-in 3.1249 HRD-in -79.33, -51.9 86.38, -21.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 109.97 APE9-dihe-na -61.86, 118.1 APE8-dihe-out -35.91, -46.58 APE8-rot-in 283.34 APE67-dihe-in -67.06, -23.86 -60.08, -25.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.9481 APE9-dist-out 11.1302 None None None XRAY 2.4 0.208 0.279 A 360.0 330.0 18 25 14 11 [[24, 308]] 1.0 3hv7 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2BAJA Q16539 2 353 360.0 1PP:60401 Type3 Inactive DFGout 14.4174 9.2517 BBAminus -151.05, 178.08 -142.27, 101.23 -49.29, -43.08 274.53, 77.37 57.96, 32.94 in-in in 8.4421 Saltbr-in 2.7989 HRD-in -68.1, -55.57 80.28, -12.3 in-out-out SNCioo out-out ActLoopNT-out 15.5807 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -142.01, 130.0 APE9-dihe-na -85.9, 148.12 APE8-dihe-out -78.24, -30.99 APE8-rot-out 234.7 APE67-dihe-in -63.24, -22.11 -66.59, -20.46 APE12-dist-in 12.6679 APE11-dist-out 17.2094 APE10-dist-out 14.6457 APE9-dist-out 11.5968 None None None XRAY 2.25 0.221 0.303 A 365.0 334.0 15 25 25 0 [[24, 308]] 1.0 2baj CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3O8UA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.7961 9.3058 BBAminus -146.29, -170.4 -144.05, 102.12 -67.29, -15.97 286.91, 115.68 99.79, 999.0 in-in in 9.3312 Saltbr-in 3.3635 HRD-in -63.28, -51.7 74.53, -20.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.38 APE8-dihe-out -70.85, -30.66 APE8-rot-in 258.69 APE67-dihe-in -65.11, -25.9 -59.1, -20.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1038 F169Y None None XRAY 2.1 0.224 0.285 A 360.0 332.0 16 25 12 13 [[24, 308]] 1.0 3o8u CMGC_MAPK14_HUMAN CMGC 3.3e-84 288.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3OBJA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 14.513 11.366 BBAminus -154.08, -178.49 -133.48, 111.98 -61.66, -36.04 255.28, 56.42 -103.05, -92.49 in-out in 9.3041 Saltbr-out 5.8023 HRD-in -72.07, -52.81 76.05, -16.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.04 APE8-dihe-out -70.24, -30.65 APE8-rot-out 197.91 APE67-dihe-in -70.14, -17.15 -63.21, -16.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9735 F169R None None XRAY 2.4 0.22 0.287 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3obj CMGC_MAPK14_HUMAN CMGC 2e-83 286.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3K3IA Q16539 5 352 360.0 JZJ:1,I46:353,I46:2 Type3,Allosteric,Allosteric Inactive DFGout 13.8744 9.8725 BBAminus -143.79, -170.14 -141.75, 114.95 -78.16, -16.52 274.05, 114.76 49.78, 999.0 in-in in 9.3253 Saltbr-in 2.6305 HRD-in -66.69, -52.65 76.63, -11.32 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 118.08 APE9-dihe-na -84.9, 132.08 APE8-dihe-out -50.88, -42.58 APE8-rot-in 276.73 APE67-dihe-in -63.3, -21.91 -56.89, -25.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1293 None None None XRAY 1.7 0.196 0.242 A 350.0 332.0 16 25 13 12 [[24, 308]] 1.0 3k3i CMGC_MAPK14_HUMAN CMGC 5.3e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5N64A Q16539 5 354 360.0 8OH:401 Allosteric Inactive DFGout 12.5487 10.0684 None -116.64, 171.43 -157.28, 152.62 -127.34, 999.0 304.62, 91.62 999.0, 999.0 in-in in 9.6572 Saltbr-in 3.1212 HRD-in -70.47, -53.46 79.07, -15.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 105.89 APE9-dihe-na -76.48, 137.46 APE8-dihe-out -63.78, -33.52 APE8-rot-in 290.65 APE67-dihe-in -60.59, -22.62 -65.11, -26.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4769 None None None XRAY 2.4 0.206 0.241 A 360.0 329.0 21 25 12 13 [[24, 308]] 1.0 5n64 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5N66A Q16539 6 353 360.0 BW1:401,B96:402 Allosteric,Type2 Inactive DFGout 15.2968 8.4235 None -139.77, 175.86 -130.8, 80.71 -75.53, 999.0 203.45, 0.89 999.0, 999.0 in-in in 9.3082 Saltbr-in 3.0902 HRD-in -75.99, -50.95 71.47, -11.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 102.5 APE9-dihe-na -77.27, 137.11 APE8-dihe-out -68.28, -33.89 APE8-rot-in 297.4 APE67-dihe-in -63.75, -24.17 -62.85, -21.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8031 None None None XRAY 2.4 0.208 0.238 A 360.0 332.0 16 25 12 13 [[24, 308]] 1.0 5n66 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH8A Q16539 4 354 360.0 IRG:401,0OP:402,0OP:403 Allosteric,Type3,Type1 Inactive DFGout 11.6887 12.5312 None -126.98, -173.26 -129.13, 140.31 68.37, 999.0 306.63, 121.42 999.0, 999.0 in-in in 9.382 Saltbr-in 3.0908 HRD-in -73.46, -51.4 85.92, -19.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 158.35 APE9-dihe-na -105.67, 133.81 APE8-dihe-out -60.04, -38.46 APE8-rot-in 291.54 APE67-dihe-in -62.35, -25.05 -51.18, -35.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2127 None None None XRAY 2.2 0.242 0.282 A 360.0 336.0 15 25 12 13 [[24, 308]] 1.0 4eh8 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2FSMX Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGout 14.2322 10.8641 None -99.78, 158.41 -80.16, -38.23 18.46, 999.0 268.72, 29.23 999.0, 999.0 in-in in 9.7893 Saltbr-in 3.0064 HRD-in -70.84, -53.29 76.61, -8.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.48 APE8-dihe-in -73.62, 146.77 APE8-rot-in 269.24 APE67-dihe-in -62.21, -20.07 -114.53, 6.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.551 D176A,F327S None None XRAY 1.86 0.25 0.277 X 367.0 326.0 23 25 11 14 [[24, 308]] 1.0 2fsm CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2NPQA Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGout 14.6321 11.1923 None -103.61, 152.87 -73.15, -38.43 25.92, 999.0 250.29, 79.85 999.0, 999.0 in-in in 9.3978 Saltbr-in 2.5064 HRD-in -66.51, -57.37 82.83, -12.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.57 APE8-dihe-in -64.2, 131.82 APE8-rot-in 297.33 APE67-dihe-in -66.2, -17.35 -108.62, 11.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1092 None None None XRAY 1.8 0.205 0.245 A 367.0 326.0 22 25 11 14 [[24, 308]] 1.0 2npq CMGC_MAPK14_HUMAN CMGC 6.3e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4GEOA Q16539 5 351 360.0 No_ligand No_ligand Inactive DFGout 14.6982 10.4768 None -99.3, 157.78 -78.87, -32.72 -149.84, 149.23 159.18, 69.75 -8.29, -58.01 in-in in 9.1001 Saltbr-in 2.7027 HRD-in -70.09, -53.53 83.75, -23.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.49 APE8-rot-in 284.08 APE67-dihe-in -65.9, -24.46 -115.44, 16.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 M194A,L195A,H228A,I229A,Y258A None None XRAY 1.66 0.22 0.255 A 367.0 326.0 21 25 13 12 [[24, 308]] 1.0 4geo CMGC_MAPK14_HUMAN CMGC 1.5e-82 283.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MH3A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGout 16.0117 12.2636 None -114.58, 161.92 -64.07, -39.51 -151.45, 141.52 204.42, 94.84 -53.7, 163.27 in-in in 9.4164 Saltbr-in 3.1177 HRD-in -69.93, -57.84 85.51, -16.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 118.94 APE8-dihe-out -52.23, -52.04 APE8-rot-in 279.55 APE67-dihe-in -63.03, -30.03 -48.23, -28.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9258 F169R None None XRAY 2.2 0.237 0.293 A 360.0 334.0 14 25 13 12 [[24, 308]] 1.0 3mh3 CMGC_MAPK14_HUMAN CMGC 2e-83 286.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3MH1A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGout 11.3758 12.2353 None -99.26, 148.49 -61.18, -25.87 178.03, 164.96 999.0, 999.0 -59.73, 139.02 in-out in 9.9586 Saltbr-out 4.5054 HRD-in -75.25, -51.25 81.19, -13.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 77.57 APE9-dihe-na -67.78, 125.39 APE8-dihe-out -45.69, -42.63 APE8-rot-in 281.79 APE67-dihe-in -67.4, -30.68 -52.54, -31.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.1691 APE9-dist-out 11.0133 F169G None None XRAY 2.2 0.235 0.296 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3mh1 CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3IW5A Q16539 4 353 360.0 DF3:362 Type1 Inactive DFGout 11.1509 13.9047 None -114.26, 151.74 -75.63, -51.5 -142.13, 148.75 301.54, 111.74 -97.74, -179.21 in-out in 9.3566 Saltbr-out 3.7762 HRD-in -63.07, -54.05 82.88, -17.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.82 APE8-dihe-out -73.02, -0.44 APE8-rot-out 77.62 APE67-dihe-in -71.77, -14.42 -134.76, 1.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0117 C119S,C162S,A172C,F327L None None XRAY 2.5 0.211 0.291 A 360.0 336.0 14 25 13 12 [[24, 308]] 1.0 3iw5 CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3L8SA Q16539 4 353 360.0 BFF:361 Type1 Inactive DFGout 15.4888 11.9771 None -119.54, 162.4 -99.13, -16.66 31.92, 999.0 247.73, 144.9 999.0, 999.0 in-in in 9.4966 Saltbr-in 2.8175 HRD-in -77.51, -50.13 90.87, -25.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 107.11 APE9-dihe-na -94.83, 118.78 APE8-dihe-out -62.16, -3.07 APE8-rot-out 173.18 APE67-dihe-in -59.13, -22.21 -95.45, -15.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2005 C119S,C162S,A172C,F327L None None XRAY 2.35 0.242 0.307 A 360.0 334.0 16 25 12 13 [[24, 308]] 1.0 3l8s CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6SFKA Q16539 4 353 360.0 LB8:405 Type2 Inactive DFGout 16.1397 8.661 None -134.22, 179.77 -135.11, 110.79 -76.65, -37.33 179.52, 81.34 91.97, 27.2 in-in in 8.862 Saltbr-in 2.7388 HRD-in -69.84, -54.1 78.48, -10.85 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 115.89 APE9-dihe-na -95.71, 136.28 APE8-dihe-out -55.44, -40.63 APE8-rot-in 282.06 APE67-dihe-in -62.97, -23.38 -59.23, -26.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.5712 APE9-dist-out 11.0508 None None None XRAY 1.8 0.182 0.218 A 361.0 339.0 11 25 14 11 [[24, 308]] 1.0 6sfk CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3HECA Q16539 5 352 360.0 STI:1 Type2 Inactive DFGout 15.7975 11.0354 None -130.2, -167.81 -152.58, 126.29 -77.67, 999.0 267.8, 49.04 999.0, 999.0 in-in in 8.8977 Saltbr-in 3.2136 HRD-in -65.98, -59.44 85.44, -17.29 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.24 APE8-dihe-out -59.5, -40.66 APE8-rot-in 292.4 APE67-dihe-in -54.55, -30.33 -64.97, -31.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9353 None None None XRAY 2.5 0.222 0.3 A 348.0 329.0 19 25 11 14 [[24, 308]] 1.0 3hec CMGC_MAPK14_HUMAN CMGC 5.2e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3NNUA Q16539 5 352 360.0 EDB:355 Type2 Inactive DFGout 14.4851 8.1772 None -144.19, -179.5 -134.33, 110.12 -98.4, 16.73 217.88, 127.0 -68.22, 116.23 in-in in 8.6063 Saltbr-in 2.743 HRD-in -68.9, -52.98 78.42, -18.23 in-out-out SNCioo out-out ActLoopNT-out 16.2443 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.69, 129.02 APE9-dihe-na -61.08, -14.62 APE8-dihe-out -64.78, -22.47 APE8-rot-out 54.7 APE67-dihe-in -66.31, -27.81 -111.35, -16.11 APE12-dist-out 19.9681 APE11-dist-out 21.0071 APE10-dist-out 15.5576 APE9-dist-out 11.7319 None None None XRAY 2.4 0.18 0.227 A 354.0 348.0 0 25 25 0 [[24, 308]] 1.0 3nnu CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3NNWA Q16539 4 352 360.0 EDD:355 Type2 Inactive DFGout 14.3784 8.6643 None -143.48, -174.31 -141.84, 103.66 -83.23, 17.1 235.42, 130.16 -65.05, 104.27 in-in in 8.6157 Saltbr-in 2.7512 HRD-in -70.41, -54.26 74.72, -13.01 in-out-out SNCioo out-out ActLoopNT-out 15.4752 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.01, 133.74 APE9-dihe-na -64.57, -21.86 APE8-dihe-out -56.02, -24.79 APE8-rot-out 60.58 APE67-dihe-in -62.38, -23.64 -112.3, -18.98 APE12-dist-out 19.8482 APE11-dist-out 21.0813 APE10-dist-out 15.5234 APE9-dist-out 11.7945 None None None XRAY 1.89 0.169 0.213 A 354.0 349.0 0 25 25 0 [[24, 308]] 1.0 3nnw CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1KV2A Q16539 5 352 360.0 B96:391 Type2 Inactive DFGout 14.8152 8.959 None -153.25, -166.57 -152.53, 103.77 -62.95, 999.0 246.86, 90.74 999.0, 999.0 in-in in 8.3523 Saltbr-in 2.8201 HRD-in -55.42, -53.31 70.34, -10.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -176.94 APE8-rot-in 323.3 APE67-dihe-in -39.27, -35.13 -88.76, -27.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.245 0.318 A 360.0 325.0 23 25 10 15 [[24, 308]] 1.0 1kv2 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WBSA Q16539 4 355 360.0 LI2:1355 Type2 Inactive DFGout 16.3682 9.1383 None -141.08, -171.86 -138.43, 108.84 -92.64, 15.84 205.17, 157.01 -67.74, 124.28 in-in in 9.2788 Saltbr-in 2.5239 HRD-in -71.99, -54.5 76.21, -17.47 in-out-out SNCioo out-out ActLoopNT-out 15.9192 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.45, 131.33 APE9-dihe-na -56.06, -21.39 APE8-dihe-out -50.15, -30.91 APE8-rot-in 286.61 APE67-dihe-in -68.26, -21.94 -116.21, -13.19 APE12-dist-out 19.6491 APE11-dist-out 20.954 APE10-dist-out 15.3525 APE9-dist-out 11.6531 None None None XRAY 1.8 0.194 0.234 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbs CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1WBTA Q16539 4 355 360.0 WBT:1355 Type2 Inactive DFGout 16.1777 9.3066 None -136.66, -169.87 -139.17, 111.94 -100.88, 32.0 201.3, 163.54 -84.42, 113.54 in-in in 9.3551 Saltbr-in 2.4938 HRD-in -72.43, -50.88 71.17, -6.74 in-out-out SNCioo out-out ActLoopNT-out 15.5573 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.15, 129.11 APE9-dihe-na -47.04, -21.32 APE8-dihe-out -62.22, -29.71 APE8-rot-in 301.06 APE67-dihe-in -64.82, -23.13 -111.68, -14.87 APE12-dist-out 19.9272 APE11-dist-out 21.1303 APE10-dist-out 15.5234 APE9-dist-out 11.7791 None None None XRAY 2.0 0.229 0.276 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbt CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9CJ1A Q16539 5 351 360.0 NIL:402 Type2 Inactive DFGout 16.6719 8.5784 None -136.39, -179.16 -135.71, 113.19 -111.0, 999.0 189.38, 176.24 999.0, 999.0 in-in in 9.1741 Saltbr-in 2.8091 HRD-in -73.57, -53.73 76.57, -11.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -113.61, 109.02 APE9-dihe-na -78.59, 135.32 APE8-dihe-out -60.73, -32.98 APE8-rot-out 68.81 APE67-dihe-in -60.63, -23.89 -58.26, -32.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8548 None TPO180,PTR182 TPO180,PTR182 XRAY 1.8 0.188 0.232 A 360.0 331.0 16 25 13 12 [[24, 308]] 1.0 9cj1 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3UVRA Q16539 5 351 360.0 06F:361 Type2 Inactive DFGout 15.5607 8.5245 None -148.63, 178.6 -133.58, 101.18 -90.01, -1.78 195.55, 17.77 -54.07, 127.45 in-in in 8.2112 Saltbr-in 2.6266 HRD-in -62.71, -55.49 83.79, -17.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.89 APE8-dihe-out -51.15, -30.26 APE8-rot-in 300.71 APE67-dihe-in -70.54, -25.21 -93.95, -15.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6213 None None None XRAY 2.1 0.204 0.245 A 360.0 331.0 16 25 13 12 [[24, 308]] 1.0 3uvr CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4L8MA Q16539 5 352 360.0 F46:403 Type2 Inactive DFGout 13.9994 6.7696 None -110.2, 165.17 -109.72, -18.28 -95.65, 105.75 169.67, 89.03 -90.5, 163.87 in-in in 8.7719 Saltbr-in 2.7377 HRD-in -71.75, -54.71 80.79, -19.29 in-out-out SNCioo out-out ActLoopNT-out 21.5079 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 46.18 APE9-dihe-na -164.48, 135.91 APE8-dihe-out -83.96, -31.73 APE8-rot-out 69.65 APE67-dihe-in -61.38, -25.8 -64.67, -22.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.5717 APE9-dist-out 12.2154 None None None XRAY 2.1 0.229 0.279 A 360.0 339.0 9 25 18 7 [[24, 308]] 1.0 4l8m CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3BV3A Q16539 5 352 360.0 P39:501 Type2 Inactive DFGout 11.358 12.0794 None -135.58, -173.61 -142.65, 155.76 58.91, 28.17 314.53, 124.45 -62.18, 128.85 in-in in 9.3695 Saltbr-in 2.8364 HRD-in -71.41, -56.4 68.14, 1.58 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -87.73, 112.95 APE9-dihe-na -70.98, 129.85 APE8-dihe-out -68.68, -24.27 APE8-rot-out 135.98 APE67-dihe-in -59.57, -28.6 -57.65, -28.26 APE12-dist-none 999.0 APE11-dist-in 12.4854 APE10-dist-out 10.977 APE9-dist-out 10.8636 None None None XRAY 2.59 0.198 0.284 A 366.0 338.0 10 25 15 10 [[24, 308]] 1.0 3bv3 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2YISA Q16539 5 353 360.0 YIS:1353,I46:1354 Type2,Allosteric Inactive DFGout 15.833 8.5763 None -138.39, -175.22 -139.39, 106.04 -86.53, 999.0 192.46, 60.65 999.0, 999.0 in-in in 8.5948 Saltbr-in 2.6488 HRD-in -65.43, -49.96 74.88, -12.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -110.86, 112.45 APE9-dihe-na -50.05, 127.69 APE8-dihe-out -57.83, -43.06 APE8-rot-in 274.36 APE67-dihe-in -59.28, -29.93 -54.84, -31.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1314 None None None XRAY 2.0 0.216 0.255 A 359.0 326.0 23 25 13 12 [[24, 308]] 1.0 2yis CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2YIWA Q16539 5 353 360.0 YIW:1353,I46:1354 Type2,Allosteric Inactive DFGout 15.1257 8.2719 None -141.89, -172.05 -138.89, 100.26 -82.98, 999.0 217.28, 137.57 999.0, 999.0 in-in in 8.5919 Saltbr-in 2.7683 HRD-in -71.94, -52.53 77.45, -13.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -110.91, 126.0 APE9-dihe-na -61.22, 128.26 APE8-dihe-out -61.06, -42.06 APE8-rot-in 267.54 APE67-dihe-in -58.91, -30.27 -58.86, -25.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.076 None None None XRAY 2.0 0.223 0.259 A 359.0 326.0 23 25 13 12 [[24, 308]] 1.0 2yiw CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9CJ5A Q16539 5 352 360.0 A1AWV:404,PDO:405 Type2,Allosteric Inactive DFGout 15.6037 9.9462 None -161.07, 167.42 -158.02, 105.92 -133.23, 63.25 67.22, 124.33 -54.97, -26.0 in-in in 8.6967 Saltbr-in 2.7666 HRD-in -81.64, -51.08 76.49, -58.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -113.44, 119.12 APE9-dihe-na -66.71, 142.75 APE8-dihe-out -74.59, -35.87 APE8-rot-in 303.87 APE67-dihe-in -57.3, -25.76 -59.56, -25.3 APE12-dist-none 999.0 APE11-dist-out 14.2449 APE10-dist-out 15.0331 APE9-dist-out 11.8063 None None None XRAY 3.3 0.247 0.276 A 360.0 334.0 11 25 19 6 [[24, 308]] 1.0 9cj5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3K3JA Q16539 5 352 360.0 F4C:361,I46:362 Type2,Allosteric Inactive DFGout 14.065 10.2016 None -131.58, -161.61 -147.02, 101.88 -61.41, 999.0 271.38, 120.65 999.0, 999.0 in-in in 9.5761 Saltbr-in 3.4443 HRD-in -69.65, -53.93 78.02, -14.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 102.6 APE9-dihe-na -77.21, 127.93 APE8-dihe-out -43.12, -42.69 APE8-rot-in 284.51 APE67-dihe-in -68.28, -22.44 -62.73, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0063 None None None XRAY 1.995 0.196 0.245 A 362.0 329.0 19 25 12 13 [[24, 308]] 1.0 3k3j CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LFDA Q16539 4 353 360.0 Z85:361 Type3 Inactive DFGout 14.3999 11.1853 None -141.36, 173.62 -120.67, -179.03 -146.09, 999.0 271.75, 117.44 999.0, 999.0 in-in in 8.8537 Saltbr-in 3.2321 HRD-in -64.3, -44.5 70.71, -12.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.22 APE8-dihe-out -67.22, -56.7 APE8-rot-in 307.71 APE67-dihe-in -57.89, -22.29 -55.8, -7.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0271 C119S,C162S,A172C,F327L None None XRAY 3.4 0.23 0.305 A 360.0 331.0 19 25 11 14 [[24, 308]] 1.0 3lfd CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 1KV1A Q16539 5 352 360.0 BMU:391 Type3 Inactive DFGout 13.6352 9.5564 None -159.24, -177.02 -146.07, 100.83 -75.42, -134.45 282.12, 117.71 154.13, 999.0 in-in in 9.1633 Saltbr-in 3.578 HRD-in -68.61, -47.67 58.19, -2.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.94 APE8-dihe-out -125.34, -40.47 APE8-rot-in 276.42 APE67-dihe-in -57.32, -20.72 -62.12, -27.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2711 None None None XRAY 2.5 0.24 0.284 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 1kv1 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3O8TA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.2632 10.3257 None -137.91, -177.55 -138.77, 94.77 -70.74, -1.41 999.0, 999.0 121.86, 999.0 in-out in 9.427 Saltbr-out 4.2701 HRD-in -65.83, -55.54 74.19, -14.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 158.65 APE8-dihe-out -42.15, -37.49 APE8-rot-out 44.7 APE67-dihe-in -68.78, -13.14 -104.02, 1.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.491 F169A None None XRAY 2.0 0.229 0.282 A 360.0 332.0 16 25 12 13 [[24, 308]] 1.0 3o8t CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3OC1A Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 12.7295 11.1023 None -150.55, -172.96 -134.29, 139.02 -118.77, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.4178 Saltbr-in 3.3368 HRD-in -75.41, -45.78 70.08, -9.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.76 APE8-dihe-out -49.39, -49.27 APE8-rot-in 287.36 APE67-dihe-in -53.47, -28.65 -54.1, -35.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0942 F169G None None XRAY 2.59 0.229 0.303 A 360.0 330.0 18 25 11 14 [[24, 308]] 1.0 3oc1 CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4E8AA Q16539 4 351 360.0 0OA:500 Allosteric Inactive None 999.0 999.0 None -92.32, 155.4 -102.08, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.1175 Saltbr-in 2.7168 HRD-in -65.57, -46.59 81.57, -30.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.55 APE8-rot-out 176.26 APE67-dihe-in -54.8, -25.07 -111.54, 8.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.225 0.313 A 360.0 327.0 21 25 9 16 [[24, 308]] 1.0 4e8a CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5N63A Q16539 5 353 360.0 8OW:401 Allosteric Inactive None 999.0 999.0 None -111.61, 156.37 57.89, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.4088 Saltbr-in 3.3497 HRD-in -72.45, -51.89 81.55, -15.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.74 APE8-dihe-out -67.87, -33.77 APE8-rot-in 320.31 APE67-dihe-in -67.35, -20.52 -64.07, -21.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9673 None None None XRAY 2.4 0.196 0.228 A 360.0 325.0 24 25 10 15 [[24, 308]] 1.0 5n63 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5O8UA Q16539 5 352 360.0 9O5:401 Allosteric Inactive None 999.0 999.0 None -101.85, 161.09 6.94, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2542 Saltbr-in 3.5355 HRD-in -71.17, -53.83 80.39, -15.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -95.46, 98.26 APE9-dihe-na -67.91, 134.4 APE8-dihe-out -58.48, -41.37 APE8-rot-in 290.06 APE67-dihe-in -68.7, -21.24 -53.34, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0062 S252C None None XRAY 2.0 0.205 0.252 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 5o8u CMGC_MAPK14_HUMAN CMGC 2e-84 289.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5O8VA Q16539 5 354 360.0 9O2:401 Allosteric Inactive None 999.0 999.0 None -135.74, -173.21 -149.06, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.3143 Saltbr-in 3.2058 HRD-in -73.19, -53.88 74.63, -13.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 115.51 APE9-dihe-na -74.16, 127.19 APE8-dihe-out -51.78, -36.7 APE8-rot-in 274.38 APE67-dihe-in -62.01, -28.06 -62.61, -31.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2012 S251C None None XRAY 2.0 0.209 0.269 A 360.0 328.0 22 25 11 14 [[24, 308]] 1.0 5o8v CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5N65A Q16539 5 352 360.0 8OT:401,8OT:402 Allosteric,Type1 Inactive None 999.0 999.0 None -100.31, 170.51 -89.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.0828 Saltbr-in 2.5351 HRD-in -71.85, -53.72 79.7, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.76 APE8-dihe-out -69.0, -27.21 APE8-rot-out 184.87 APE67-dihe-in -59.8, -25.07 -68.54, -20.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5068 None None None XRAY 2.0 0.193 0.216 A 360.0 333.0 15 25 10 15 [[24, 308]] 1.0 5n65 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4DLJA Q16539 4 354 360.0 6RG:401,6RG:402 Allosteric,Type1 Inactive None 999.0 999.0 None -99.65, 167.18 -71.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2807 Saltbr-in 2.8622 HRD-in -65.2, -60.52 84.01, -15.15 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 99.76 APE9-dihe-na -61.5, 134.32 APE8-dihe-out -51.58, -38.85 APE8-rot-in 307.02 APE67-dihe-in -49.07, -29.87 -61.38, -36.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2245 None None None XRAY 2.6 0.216 0.314 A 360.0 336.0 15 25 11 14 [[24, 308]] 1.0 4dlj CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH5A Q16539 4 354 360.0 IRG:401,0OM:402 Allosteric,Type1 Inactive None 999.0 999.0 None -108.39, 163.33 57.95, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.3088 Saltbr-in 2.9014 HRD-in -72.32, -49.67 77.23, -19.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.62 APE8-dihe-out -54.92, -38.6 APE8-rot-in 283.85 APE67-dihe-in -62.06, -24.82 -60.96, -29.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.251 None None None XRAY 2.0 0.232 0.285 A 360.0 329.0 22 25 10 15 [[24, 308]] 1.0 4eh5 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH6A Q16539 4 354 360.0 IRG:401,0ON:402 Allosteric,Type1 Inactive None 999.0 999.0 None -123.46, -172.29 -120.99, 34.21 -158.17, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.1714 Saltbr-in 2.742 HRD-in -69.9, -51.68 78.55, -21.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.55 APE8-dihe-out -58.14, -38.92 APE8-rot-in 265.12 APE67-dihe-in -64.71, -26.03 -57.04, -28.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2302 None None None XRAY 2.1 0.227 0.277 A 360.0 335.0 16 25 11 14 [[24, 308]] 1.0 4eh6 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH7A Q16539 4 354 360.0 IRG:401,0OO:402 Allosteric,Type1 Inactive None 999.0 999.0 None -98.76, 137.9 -63.12, -45.22 -156.84, 139.66 999.0, 999.0 98.21, 999.0 in-in in 9.2463 Saltbr-in 3.0514 HRD-in -69.27, -51.42 76.94, -19.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 98.3 APE9-dihe-na -75.8, 145.15 APE8-dihe-out -61.37, -38.48 APE8-rot-in 268.7 APE67-dihe-in -62.89, -26.04 -57.18, -28.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3386 None None None XRAY 2.1 0.224 0.265 A 360.0 337.0 14 25 13 12 [[24, 308]] 1.0 4eh7 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6QYXA Q16539 4 352 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -106.52, 118.78 -115.56, -98.31 -61.04, -63.53 344.48, 91.73 -150.21, 9.86 in-in in 9.3265 Saltbr-in 2.5795 HRD-in -73.9, -51.98 75.86, -12.54 in-out-out SNCioo out-out ActLoopNT-out 31.6763 ActLoopCT-out nonTYR APEdihe_aaono APEdist_iioo APE10-dihe-na -74.45, -19.47 APE9-dihe-na -64.45, -33.91 APE8-dihe-out 125.2, -117.03 APE8-rot-none 999.0 APE67-dihe-out -129.02, 137.69 -169.25, 130.59 APE12-dist-in 10.8064 APE11-dist-in 13.2469 APE10-dist-out 16.7923 APE9-dist-out 16.8226 None None None XRAY 1.66 0.188 0.242 A 366.0 319.0 10 31 21 10 [[24, 308]] 1.0 6qyx CMGC_MAPK14_HUMAN CMGC 8.4e-85 290.6 1.0 301.0 301.0 12 13 14 16 18 53 71 75 147 149 148 150.0 205 43 38 37 36 35 34 33 32 107 Mitogen-activated protein kinase 14
MAPK14 2FSTX Q16539 5 352 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -108.93, 154.69 31.88, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2643 Saltbr-in 2.5805 HRD-in -69.82, -57.76 81.6, -6.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.42 APE8-dihe-in -75.33, 147.85 APE8-rot-in 261.2 APE67-dihe-in -65.73, -20.85 -104.84, 3.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4092 D176A,F327L None None XRAY 1.45 0.236 0.241 X 367.0 324.0 24 25 10 15 [[24, 308]] 1.0 2fst CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2FSLX Q16539 4 354 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -101.98, 152.79 -34.78, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.8787 Saltbr-in 2.8168 HRD-in -71.36, -53.06 78.29, -10.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 132.09 APE9-dihe-na -72.48, 120.99 APE8-dihe-in -73.0, 149.08 APE8-rot-in 253.17 APE67-dihe-in -61.11, -23.64 -104.43, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.452 D176A,F327S None None XRAY 1.7 0.244 0.24 X 367.0 332.0 19 25 11 14 [[24, 308]] 1.0 2fsl CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 2FSOX Q16539 5 353 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -106.29, 157.33 52.19, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.1823 Saltbr-in 2.5529 HRD-in -65.61, -56.88 80.27, -8.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 5.77 APE8-dihe-in -71.46, 138.27 APE8-rot-in 251.69 APE67-dihe-in -62.5, -22.21 -97.22, 4.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4272 D176A None None XRAY 1.83 0.178 0.224 X 367.0 325.0 24 25 10 15 [[24, 308]] 1.0 2fso CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 6M95A Q16539 5 352 360.0 J8S:501 Type1 Inactive None 999.0 999.0 None -97.09, 121.22 -100.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2123 Saltbr-in 2.8615 HRD-in -65.02, -59.89 79.82, -9.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 158.99 APE8-dihe-out -59.43, -17.68 APE8-rot-out 85.56 APE67-dihe-in -68.8, -17.32 -105.14, -3.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0601 None None None XRAY 1.8 0.174 0.208 A 388.0 333.0 15 25 10 15 [[24, 308]] 1.0 6m95 CMGC_MAPK14_HUMAN CMGC 1e-84 290.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 9YLHA Q16539 5 353 360.0 A1CX9:503 Type1 Inactive None 999.0 999.0 None -96.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.4002 Saltbr-in 2.8479 HRD-in -68.57, -49.88 76.6, -12.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -111.85, 121.68 APE9-dihe-na -60.7, -56.76 APE8-dihe-in -129.2, 132.37 APE8-rot-in 311.57 APE67-dihe-out -68.41, -9.84 -103.78, 107.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3844 None TPO180 CME162,TPO180 XRAY 2.02 0.213 0.239 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 9ylh CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3LFAA Q16539 4 353 360.0 1N1:361 Type1 Inactive None 999.0 999.0 None -119.32, 169.35 -154.54, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2412 Saltbr-in 2.7349 HRD-in -67.55, -57.07 85.83, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.05 APE8-dihe-out -85.63, -3.59 APE8-rot-in 346.34 APE67-dihe-in -59.81, -27.96 -94.61, -12.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8947 None None None XRAY 2.1 0.204 0.254 A 360.0 333.0 17 25 10 15 [[24, 308]] 1.0 3lfa CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 3ZSHA Q16539 4 352 360.0 469:400 Type1 Inactive None 999.0 999.0 None -106.18, 148.72 85.75, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.0607 Saltbr-in 3.2922 HRD-in -65.73, -56.19 85.19, -16.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -63.62 APE8-dihe-out -49.73, -55.3 APE8-rot-out 72.73 APE67-dihe-in -63.94, -22.31 -77.97, -13.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0841 None None None XRAY 2.05 0.208 0.255 A 362.0 331.0 15 25 10 15 [[24, 308]] 1.0 3zsh CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 8A8MA Q16539 5 353 360.0 AP2:60900 Type1 Inactive None 11.0583 18.3662 None -133.1, -179.58 58.18, 65.77 -88.58, 125.42 201.03, 134.23 104.29, 124.16 in-out in 8.1966 Saltbr-out 9.5148 HRD-in -64.82, -44.91 64.86, -2.06 out-out-out SNCooo out-out ActLoopNT-out 6.9629 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -131.1, 94.25 APE9-dihe-na -165.78, 126.4 APE8-dihe-in -95.27, 137.04 APE8-rot-out 60.89 APE67-dihe-out 70.19, 13.63 -115.98, -56.13 APE12-dist-out 23.1068 APE11-dist-out 21.7967 APE10-dist-out 23.4916 APE9-dist-out 14.1872 T180V None None EM 4.0 999.0 999.0 A 381.0 349.0 0 25 25 0 [[24, 308]] 1.0 8a8m CMGC_MAPK14_HUMAN CMGC 4e-84 288.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 4EH3A Q16539 4 354 360.0 NAR:401,IRG:402 Type1,Allosteric Inactive None 999.0 999.0 None -93.8, 152.76 -77.66, -36.64 -150.96, 113.75 999.0, 999.0 -75.95, -166.36 in-out in 9.6206 Saltbr-out 4.0293 HRD-in -80.03, -53.65 83.21, -19.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.56 APE9-dihe-na -87.37, 152.3 APE8-dihe-out -66.91, -31.74 APE8-rot-in 263.06 APE67-dihe-in -67.51, -22.33 -71.06, -17.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.9391 APE9-dist-out 11.2796 None None None XRAY 2.4 0.219 0.277 A 360.0 339.0 12 25 15 10 [[24, 308]] 1.0 4eh3 CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 8VXEA Q16539 6 352 360.0 A1AD9:401,A1AD9:402 Type1,Allosteric Inactive None 999.0 999.0 None -98.19, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.005 Saltbr-in 2.6416 HRD-in -65.83, -53.75 77.17, -14.66 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 98.85 APE9-dihe-na -79.04, 136.28 APE8-dihe-out -61.75, -41.07 APE8-rot-in 303.56 APE67-dihe-in -62.53, -24.73 -58.42, -26.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6338 None None None XRAY 1.85 0.223 0.289 A 387.0 329.0 18 25 10 15 [[24, 308]] 1.0 8vxe CMGC_MAPK14_HUMAN CMGC 7.5e-85 290.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 5OMHA Q16539 5 353 360.0 9Y5:401 Type1.5_Back Inactive None 999.0 999.0 None -133.9, 160.5 -99.84, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.5724 Saltbr-out 3.8741 HRD-in -69.09, -50.51 81.58, -12.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.3 APE8-dihe-out -74.47, -33.47 APE8-rot-out 59.61 APE67-dihe-in -59.66, -23.0 -57.69, -25.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9517 None None None XRAY 2.5 0.218 0.277 A 360.0 325.0 24 25 10 15 [[24, 308]] 1.0 5omh CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

CMGC_MAPK14 (Mitogen-activated protein kinase 14)

Total number of chains: 423
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 109 25.8% 5R97A
DFGin BLBplus 102 24.1% 3GC7A
DFGout BBAminus 66 15.6% 5LARA
DFGin None 62 14.7% 8X3MA
DFGout None 30 7.1% 1WBSA
None None 21 5.0% 8A8MA
DFGin BLAminus 17 4.0% AF-Q16539-K1A
DFGinter None 12 2.8% 5WJJA
DFGin BLAplus 3 0.7% 3HUBA
DFGin ABAminus 1 0.2% 7PVUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAPK14 MK14_HUMAN AF-Q16539-K1A Q16539 16 316 360.0 No_ligand No_ligand Active DFGin 6.3916 14.553 BLAminus -111.68, 175.06 58.78, 74.94 -79.92, 13.31 286.54, 83.12 -61.54, -26.1 in-in in 9.1356 Saltbr-in 2.6698 HRD-in -80.43, -49.45 64.0, 16.06 in-in-in SNCiii in-in ActLoopNT-in 2.8923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.49, 168.5 APE9-dihe-na 60.0, 147.27 APE8-dihe-in -64.74, 130.52 APE8-rot-in 300.11 APE67-dihe-in -67.86, -22.69 -49.74, -43.79 APE12-dist-in 11.7263 APE11-dist-in 11.2272 APE10-dist-in 6.9834 APE9-dist-in 3.0638 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 25 25 0 [[24, 308]] 1.0 AF-Q16539-K1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.1e-85 292.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN AF-Q16539-K3A Q16539 16 316 360.0 No_ligand No_ligand Active DFGin 6.7156 14.5403 BLAminus -118.33, 171.9 61.33, 65.97 -74.85, 14.93 288.66, 81.1 -63.87, -20.34 in-in in 9.5923 Saltbr-in 2.7612 HRD-in -74.9, -43.91 63.84, 11.15 in-in-in SNCiii in-in ActLoopNT-in 2.8396 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.65, 171.67 APE9-dihe-na 59.51, 139.05 APE8-dihe-in -53.62, 133.53 APE8-rot-in 286.45 APE67-dihe-in -69.5, -18.44 -46.51, -48.09 APE12-dist-in 11.1248 APE11-dist-in 11.1248 APE10-dist-in 6.4844 APE9-dist-in 3.0684 None None None AF2 -1.0 1.0 1.0 A 301.0 301.0 0 25 25 0 [[24, 308]] 1.0 AF-Q16539-K3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.1e-85 292.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9CJ2A Q16539 4 352 360.0 No_ligand No_ligand Active DFGin 7.0541 15.2151 BLAminus -116.87, 173.2 53.35, 78.52 -89.8, 42.55 291.12, 76.12 -80.06, -35.53 in-in in 9.5756 Saltbr-in 2.8654 HRD-in -80.13, -53.11 78.23, 5.92 in-in-in SNCiii in-in ActLoopNT-in 3.0164 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.43, -179.16 APE9-dihe-na 56.23, -174.96 APE8-dihe-in -105.36, 149.51 APE8-rot-in 298.78 APE67-dihe-in -73.19, -7.83 -55.54, -51.59 APE12-dist-in 10.9733 APE11-dist-in 11.1141 APE10-dist-in 6.7661 APE9-dist-in 2.9202 None TPO180,PTR182 TPO180,PTR182 XRAY 2.83 0.281 0.308 A 360.0 347.0 2 25 25 0 [[24, 308]] 1.0 9cj2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HVCA Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.001 14.1177 BLAminus -117.3, 162.28 48.45, 62.22 -54.05, -25.26 320.24, 130.58 54.74, 999.0 in-in in 9.2797 Saltbr-in 2.5453 HRD-in -69.38, -51.52 77.78, -17.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -66.04 APE8-rot-out 54.89 APE67-dihe-in -58.13, -29.46 -158.78, -30.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.226 0.267 A 362.0 327.0 21 25 11 14 [[24, 308]] 1.0 3hvc Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WBWA Q16539 4 355 360.0 LI4:1355 Type1 Inactive DFGin 7.5498 16.2674 BLAminus -114.87, 175.82 52.97, 77.06 -65.37, 9.09 283.4, 69.37 71.81, 22.41 in-in in 9.2583 Saltbr-in 2.8087 HRD-in -68.77, -47.28 73.71, -9.85 in-out-out SNCioo out-out ActLoopNT-out 10.725 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.9, 136.82 APE9-dihe-na -61.44, -23.14 APE8-dihe-out -57.7, -19.84 APE8-rot-out 51.58 APE67-dihe-in -57.97, -23.53 -115.99, -22.15 APE12-dist-out 21.5602 APE11-dist-out 23.4018 APE10-dist-out 17.5935 APE9-dist-out 11.6839 None None None XRAY 2.41 0.201 0.273 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbw Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6ZQSA Q16539 4 353 360.0 3FF:400 Type1 Inactive DFGin 7.1312 15.0067 BLAminus -100.05, 172.92 58.72, 89.64 -100.69, 26.63 286.71, 76.86 -66.14, -26.38 out-out out 10.2824 Saltbr-out 3.9201 HRD-in -83.97, -53.39 74.81, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.8547 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.23, 173.02 APE9-dihe-na 73.87, 161.94 APE8-dihe-in -91.46, 139.33 APE8-rot-in 294.96 APE67-dihe-in -66.05, -18.45 -53.95, -45.87 APE12-dist-in 11.599 APE11-dist-in 11.174 APE10-dist-in 6.7713 APE9-dist-in 3.0458 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.178 0.223 A 362.0 350.0 0 25 25 0 [[24, 308]] 1.0 6zqs Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6TCAB Q16539 6 354 360.0 39G:401 Type1.5_Back Inactive DFGin 6.742 15.7684 BLAminus -130.28, -179.18 59.49, 69.66 -85.81, 23.35 282.2, 65.31 -63.84, -34.91 out-out out 11.1131 Saltbr-out 5.6384 HRD-in -66.49, -45.95 70.86, -7.28 out-in-out SNCoio in-out ActLoopNT-in 3.3302 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.48, -58.05 APE9-dihe-na -75.98, 156.63 APE8-dihe-in -62.39, 131.74 APE8-rot-out 166.29 APE67-dihe-in -54.53, -22.14 -54.99, -53.8 APE12-dist-in 11.7413 APE11-dist-in 12.5434 APE10-dist-in 7.4214 APE9-dist-in 3.2358 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 B 364.0 346.0 3 25 25 0 [[24, 308]] 1.0 6tca Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6TCAD Q16539 4 353 360.0 39G:401 Type1.5_Back Inactive DFGin 6.9547 16.1724 BLAminus -125.48, -175.55 59.52, 68.68 -88.14, 27.72 279.96, 77.65 -57.15, -38.97 out-out out 11.166 Saltbr-out 5.693 HRD-in -62.99, -39.55 70.16, -10.43 out-in-out SNCoio in-out ActLoopNT-in 3.0863 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioi APE10-dihe-na -80.04, 153.64 APE9-dihe-na -82.75, -163.37 APE8-dihe-out 65.6, 54.59 APE8-rot-out 83.62 APE67-dihe-in -61.09, -43.8 -46.44, -54.01 APE12-dist-in 12.1179 APE11-dist-in 12.6956 APE10-dist-out 8.7934 APE9-dist-in 4.9173 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 D 364.0 346.0 4 25 25 0 [[24, 308]] 1.0 6tca Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6TCAF Q16539 6 353 360.0 39G:401 Type1.5_Back Inactive DFGin 7.0199 15.9029 BLAminus -157.27, -163.9 58.12, 65.17 -92.38, 59.15 303.67, 0.4 -62.65, -37.82 out-out out 11.3868 Saltbr-out 6.4445 HRD-in -64.79, -43.64 63.61, 6.87 out-in-out SNCoio in-out ActLoopNT-in 2.9818 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -128.13, 177.99 APE9-dihe-na 63.26, 84.34 APE8-dihe-in -33.91, 143.61 APE8-rot-out 68.05 APE67-dihe-in -60.74, -43.9 -59.71, -43.06 APE12-dist-in 11.9319 APE11-dist-in 12.4616 APE10-dist-out 8.0332 APE9-dist-in 3.5995 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 F 364.0 344.0 4 25 25 0 [[24, 308]] 1.0 6tca Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6TCAH Q16539 4 353 360.0 39G:401 Type1.5_Back Inactive DFGin 6.6365 16.1566 BLAminus -143.98, 175.6 56.15, 68.06 -81.43, 14.58 273.4, 106.74 -60.09, -44.0 out-out out 11.2433 Saltbr-out 4.8497 HRD-in -91.38, -34.82 53.07, 10.54 out-in-in SNCoii in-in ActLoopNT-in 2.6108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.85, -82.87 APE9-dihe-na -72.81, 167.47 APE8-dihe-in -65.51, 140.73 APE8-rot-in 325.69 APE67-dihe-in -64.02, -39.56 -54.41, -51.98 APE12-dist-in 11.5292 APE11-dist-in 11.9925 APE10-dist-in 7.8442 APE9-dist-in 3.4196 None TPO180,PTR182 TPO180,PTR182 XRAY 3.7 0.254 0.297 H 364.0 346.0 4 25 25 0 [[24, 308]] 1.0 6tca Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HUBA Q16539 4 352 360.0 469:361 Type1 Inactive DFGin 4.731 13.4735 BLAplus -114.99, 158.58 74.87, 37.1 -91.08, 94.47 28.89, 89.39 148.41, 999.0 in-in in 9.1217 Saltbr-in 2.8735 HRD-in -63.44, -55.08 80.73, -16.58 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -160.94 APE8-rot-out 184.21 APE67-dihe-in -64.8, -19.64 -104.95, -3.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.25 0.217 0.292 A 360.0 335.0 14 25 11 14 [[24, 308]] 1.0 3hub Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3UVPA Q16539 5 352 360.0 048:361 Type1 Inactive DFGin 5.9029 14.0354 BLAplus -128.96, 167.37 69.29, 45.08 -117.27, 80.33 39.32, 88.72 -113.85, -175.51 in-in in 8.6759 Saltbr-in 2.5562 HRD-in -71.0, -49.77 82.36, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 132.67 APE9-dihe-na -130.56, 135.77 APE8-dihe-out -78.62, -6.53 APE8-rot-out 68.87 APE67-dihe-in -66.48, -13.93 -109.38, 1.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.916 APE9-dist-out 13.1826 None None None XRAY 2.4 0.216 0.297 A 360.0 334.0 14 25 14 11 [[24, 308]] 1.0 3uvp Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3UVQA Q16539 5 353 360.0 FS8:361 Type1 Inactive DFGin 4.9432 14.1155 BLAplus -108.35, 165.19 59.32, 36.84 -101.79, 71.96 57.48, 77.44 163.27, 167.24 in-in in 8.943 Saltbr-in 2.833 HRD-in -75.44, -58.21 84.54, -18.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -176.56 APE8-rot-out 41.57 APE67-dihe-in -62.66, -23.03 -75.22, -6.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.239 0.318 A 360.0 333.0 16 25 12 13 [[24, 308]] 1.0 3uvq Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5N68A Q16539 4 351 360.0 8OK:401 Allosteric Inactive DFGin 7.1871 16.0011 BLBminus -132.8, -169.79 49.09, 62.16 -56.84, 161.9 297.29, 60.42 -75.69, 999.0 in-in in 9.4007 Saltbr-in 2.8176 HRD-in -69.7, -49.52 79.9, -19.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -54.59 APE8-rot-out 175.1 APE67-dihe-in -63.96, -22.6 -56.46, -20.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.199 0.22 A 360.0 328.0 20 25 11 14 [[24, 308]] 1.0 5n68 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 8YD9A Q16539 4 353 360.0 6GI:401 Allosteric Inactive DFGin 7.5603 16.6454 BLBminus -120.34, 169.61 41.78, 72.62 -60.87, 160.51 290.17, 61.87 -80.92, 82.21 in-in in 9.6172 Saltbr-in 2.8449 HRD-in -66.62, -54.49 86.21, -14.87 in-out-out SNCioo out-out ActLoopNT-out 10.7168 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.56, 132.3 APE9-dihe-na -62.85, -15.25 APE8-dihe-out -63.39, -16.12 APE8-rot-out 50.03 APE67-dihe-in -65.78, -19.25 -116.75, -17.41 APE12-dist-out 21.9239 APE11-dist-out 24.1116 APE10-dist-out 18.3983 APE9-dist-out 11.85 None None None XRAY 1.66 0.163 0.205 A 360.0 350.0 0 25 25 0 [[24, 308]] 1.0 8yd9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2Y8OA Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.7433 16.8229 BLBminus -138.36, -179.55 53.29, 59.75 -55.87, 145.37 283.56, 66.78 -67.71, 123.75 in-in in 9.7185 Saltbr-in 3.0063 HRD-in -66.11, -52.04 86.07, -23.03 in-out-out SNCioo out-out ActLoopNT-out 9.8385 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -177.95 APE8-rot-out 47.02 APE67-dihe-in -62.72, -18.98 -116.55, -3.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C162S None None XRAY 1.95 0.177 0.209 A 362.0 339.0 11 25 14 11 [[24, 308]] 1.0 2y8o Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1R3CA Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.502 16.5774 BLBminus -145.02, -172.91 51.63, 52.82 -55.3, 152.63 287.37, 64.83 -71.8, 106.36 in-in in 9.3885 Saltbr-in 2.6823 HRD-in -65.48, -52.69 76.28, -10.64 in-out-out SNCioo out-out ActLoopNT-out 10.5627 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -130.09, 134.84 APE9-dihe-na -62.67, -23.44 APE8-dihe-out -61.18, -13.14 APE8-rot-out 53.68 APE67-dihe-in -57.73, -23.21 -120.31, -19.81 APE12-dist-out 22.0389 APE11-dist-out 24.168 APE10-dist-out 18.3976 APE9-dist-out 11.6927 C162S None None XRAY 2.0 0.2 0.224 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 1r3c Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2LGCA Q16539 2 354 360.0 No_ligand No_ligand Inactive DFGin 6.8933 15.6774 BLBminus -112.9, 158.36 55.82, 75.36 -56.13, 146.45 306.25, 129.33 -79.0, 52.75 out-out out 10.0931 Saltbr-out 3.882 HRD-in -73.57, -54.1 82.77, -21.72 out-out-out SNCooo out-out ActLoopNT-out 11.1366 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na 59.79, 174.94 APE9-dihe-na -82.63, 57.56 APE8-dihe-out -108.66, -41.01 APE8-rot-out 69.43 APE67-dihe-in -63.44, -21.86 -92.32, -21.25 APE12-dist-out 22.0644 APE11-dist-out 19.1938 APE10-dist-out 16.9452 APE9-dist-out 12.3613 None None None NMR 999.0 999.0 999.0 A 359.0 353.0 0 25 25 0 [[24, 308]] 1.0 2lgc Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5ETAA Q16539 4 354 360.0 No_ligand No_ligand Inactive DFGin 7.1569 16.0318 BLBminus -141.39, 172.08 57.41, 75.46 -79.2, 159.99 305.15, 4.16 -79.17, 999.0 out-out out 10.0606 Saltbr-out 3.8381 HRD-out -71.28, 117.84 -99.9, 129.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.3, -10.62 999.0, -28.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.223 0.29 A 360.0 336.0 15 25 10 15 [[24, 308]] 1.0 5eta Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5ETAB Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 6.6612 15.6087 BLBminus -141.34, 173.45 57.65, 76.86 -79.32, 160.66 304.14, 21.59 -78.74, 999.0 out-out out 10.145 Saltbr-out 4.1091 HRD-in -64.54, -46.9 72.72, -11.57 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.94, -15.91 999.0, 18.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.223 0.29 B 360.0 335.0 15 25 10 15 [[24, 308]] 1.0 5eta Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9CJ2B Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 7.2006 16.0665 BLBminus -117.17, 175.34 53.95, 75.39 -89.71, 147.73 291.67, 75.51 152.14, -34.2 out-out out 10.6863 Saltbr-out 3.8317 HRD-in -80.84, -55.81 75.66, 9.43 out-in-in SNCoii in-in ActLoopNT-in 2.7385 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.3, -40.08 APE9-dihe-na -88.33, -173.72 APE8-dihe-in -105.0, 147.42 APE8-rot-in 299.07 APE67-dihe-inflip 57.56, -2.13 -67.17, 153.5 APE12-dist-in 11.4503 APE11-dist-in 11.6012 APE10-dist-in 6.8955 APE9-dist-in 3.1705 None TPO180,PTR182 TPO180,PTR182 XRAY 2.83 0.281 0.308 B 360.0 337.0 10 25 24 1 [[24, 308]] 1.0 9cj2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1R39A Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGin 6.2424 15.6212 BLBminus -100.63, 170.62 -0.96, 98.11 -65.4, 170.41 322.57, 74.0 -64.2, 131.69 in-out in 9.8215 Saltbr-out 3.7547 HRD-in -69.24, -48.98 82.5, -25.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.33, 137.12 APE9-dihe-na -61.11, -31.18 APE8-dihe-out -59.75, -12.63 APE8-rot-out 50.53 APE67-dihe-in -57.43, -19.19 -117.05, -22.73 APE12-dist-out 21.5157 APE11-dist-out 23.8232 APE10-dist-out 18.0787 APE9-dist-out 12.369 None None None XRAY 2.3 0.209 0.249 A 366.0 345.0 3 25 22 3 [[24, 308]] 1.0 1r39 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2OKRA Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.5536 16.5668 BLBminus -134.78, -177.84 43.57, 67.63 -61.93, 143.9 285.97, 54.99 -63.82, 118.09 in-in in 9.4628 Saltbr-in 3.0481 HRD-in -61.63, -67.88 95.04, -16.23 in-out-out SNCioo out-out ActLoopNT-out 9.4849 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.46 APE8-dihe-out -50.88, -50.92 APE8-rot-none 999.0 APE67-dihe-in -63.55, -15.29 -67.15, -13.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.235 None None None XRAY 2.0 0.238 0.272 A 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 2okr Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2OKRD Q16539 5 355 360.0 No_ligand No_ligand Inactive DFGin 7.5464 16.5218 BLBminus -136.02, 175.66 52.49, 66.48 -59.93, 143.57 284.61, 60.28 -61.55, 109.72 in-in in 9.4345 Saltbr-in 2.954 HRD-in -66.04, -52.0 79.74, -16.59 in-out-none SNCion out-none ActLoopNT-out 9.3877 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.39, -17.24 999.0, -2.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.238 0.272 D 366.0 339.0 12 25 13 12 [[24, 308]] 1.0 2okr Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2ONLA Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.2877 16.1056 BLBminus -139.8, -177.93 43.34, 77.4 -75.22, 146.44 290.54, 41.49 -62.95, 116.48 in-in in 9.4516 Saltbr-in 2.6513 HRD-in -52.0, -56.17 74.39, -2.78 in-out-none SNCion out-none ActLoopNT-out 9.1471 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 49.36 APE8-rot-none 999.0 APE67-dihe-in -86.46, -33.32 -110.87, 9.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 4.0 0.315 0.331 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 2onl Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2ONLB Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.3212 16.1634 BLBminus -141.81, -179.23 45.19, 76.7 -75.31, 145.49 288.03, 42.26 -62.52, 115.05 in-in in 9.4911 Saltbr-in 2.8294 HRD-in -52.05, -57.26 76.3, -1.57 in-out-out SNCioo out-out ActLoopNT-out 9.1161 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.14 APE8-dihe-out -128.48, 30.34 APE8-rot-none 999.0 APE67-dihe-in -39.69, -33.92 -99.79, -26.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1744 None None None XRAY 4.0 0.315 0.331 B 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 2onl Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5ETFA Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.0134 16.2546 BLBminus -113.01, 169.42 60.38, 71.26 -66.88, 139.87 292.28, 86.16 -72.96, 138.11 out-none out 10.2865 Saltbr-none 999.0 HRD-in -67.23, -46.39 78.26, -18.36 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -17.92 APE8-dihe-out -72.2, -34.2 APE8-rot-out 55.6 APE67-dihe-in -63.87, -20.91 -91.79, -15.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2852 None None None XRAY 2.4 0.166 0.231 A 360.0 338.0 12 25 13 12 [[24, 308]] 1.0 5etf Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-84 287.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1BMKA Q16539 4 354 360.0 SB5:800 Type1 Inactive DFGin 7.1217 16.5291 BLBminus -137.22, -169.66 56.32, 44.88 -45.24, 133.86 286.34, 72.89 -52.23, -75.66 in-out in 9.7619 Saltbr-out 3.7479 HRD-in -63.64, -53.75 77.86, -16.8 out-out-out SNCooo out-out ActLoopNT-out 9.514 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -119.53, 132.15 APE9-dihe-na -60.85, -24.23 APE8-dihe-out -62.44, -19.14 APE8-rot-out 62.45 APE67-dihe-in -60.11, -20.13 -109.63, -21.41 APE12-dist-out 22.2759 APE11-dist-out 24.3467 APE10-dist-out 18.5571 APE9-dist-out 11.863 None None None XRAY 2.4 0.189 0.245 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1bmk Homo sapiens CMGC_MAPK14_HUMAN CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MW1A Q16539 4 352 360.0 MIH:1 Type1 Inactive DFGin 7.0914 15.6534 BLBminus -132.66, 167.77 44.25, 77.33 -67.05, 164.83 301.32, 86.64 -78.77, 69.58 in-in in 9.2873 Saltbr-in 2.718 HRD-in -90.51, -42.46 74.96, -39.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.83, 140.74 APE9-dihe-na -74.87, -7.04 APE8-dihe-out -61.38, -14.99 APE8-rot-out 171.94 APE67-dihe-in -82.2, -6.08 -133.4, 0.84 APE12-dist-out 22.1585 APE11-dist-out 24.3615 APE10-dist-out 18.6441 APE9-dist-out 11.9023 None None None XRAY 2.8 0.259 0.339 A 359.0 342.0 7 25 23 2 [[24, 308]] 1.0 3mw1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1DI9A Q16539 4 351 360.0 MSQ:500 Type1 Inactive DFGin 7.7564 16.5688 BLBminus -140.41, -172.23 47.23, 67.42 -68.51, 162.42 284.54, 55.87 -75.89, 110.12 in-in in 9.0586 Saltbr-in 3.1062 HRD-in -65.18, -38.96 42.63, 26.65 in-out-out SNCioo out-out ActLoopNT-out 10.862 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.87, 134.68 APE9-dihe-na -58.83, -9.68 APE8-dihe-out -74.85, -6.92 APE8-rot-out 66.23 APE67-dihe-in -59.93, -24.34 -127.05, -19.2 APE12-dist-out 21.9225 APE11-dist-out 23.9446 APE10-dist-out 18.2443 APE9-dist-out 11.9784 None None None XRAY 2.6 0.209 0.253 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 1di9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1W7HA Q16539 4 355 360.0 3IP:1355 Type1 Inactive DFGin 7.7961 17.0549 BLBminus -126.97, 174.81 45.3, 68.52 -59.92, 159.01 290.19, 61.39 -65.46, 100.81 in-in in 9.5922 Saltbr-in 2.9754 HRD-in -66.31, -55.3 89.68, -16.31 in-out-out SNCioo out-out ActLoopNT-out 10.7805 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -130.74, 137.94 APE9-dihe-na -62.48, -23.82 APE8-dihe-out -56.07, -23.6 APE8-rot-out 56.54 APE67-dihe-in -60.27, -19.52 -110.55, -22.95 APE12-dist-out 22.3591 APE11-dist-out 24.4048 APE10-dist-out 18.6833 APE9-dist-out 11.9853 None None None XRAY 2.214 0.183 0.233 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w7h Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1W84A Q16539 4 355 360.0 L12:1356 Type1 Inactive DFGin 7.6501 16.5415 BLBminus -120.74, 171.92 61.53, 62.34 -66.83, 153.55 283.45, 69.16 -66.75, 86.26 in-in in 9.6038 Saltbr-in 2.6929 HRD-in -64.89, -52.25 82.48, -12.16 in-out-out SNCioo out-out ActLoopNT-out 10.7871 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.19, 133.54 APE9-dihe-na -63.3, -20.54 APE8-dihe-out -62.12, -18.89 APE8-rot-out 50.08 APE67-dihe-in -62.02, -22.2 -113.11, -19.49 APE12-dist-out 22.3273 APE11-dist-out 24.4704 APE10-dist-out 18.6246 APE9-dist-out 11.8277 None None None XRAY 2.2 0.182 0.238 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w84 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2ZB0A Q16539 4 352 360.0 GK3:361 Type1 Inactive DFGin 7.7654 16.2288 BLBminus -137.48, -175.21 49.81, 58.54 -56.14, 139.15 284.33, 72.04 -63.78, 112.08 in-in in 9.1667 Saltbr-in 2.6879 HRD-in -68.02, -49.82 75.51, -11.64 in-out-out SNCioo out-out ActLoopNT-out 10.9202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -141.37, 135.74 APE9-dihe-na -61.38, -19.35 APE8-dihe-out -65.18, -21.78 APE8-rot-out 47.27 APE67-dihe-in -62.12, -22.94 -113.09, -19.43 APE12-dist-out 21.9628 APE11-dist-out 24.0837 APE10-dist-out 18.4019 APE9-dist-out 11.6658 None None None XRAY 2.1 0.174 0.212 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 2zb0 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1M7QA Q16539 4 351 360.0 DQO:501 Type1 Inactive DFGin 8.0398 16.5774 BLBminus -116.55, -179.82 62.9, 86.7 -124.28, 146.05 278.55, 112.99 54.76, 19.36 in-in in 9.5873 Saltbr-in 3.3089 HRD-in -72.49, -44.98 75.68, -16.58 in-out-out SNCioo out-out ActLoopNT-out 11.0563 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.68, 132.65 APE9-dihe-na -56.74, -10.63 APE8-dihe-out -77.85, -7.16 APE8-rot-out 52.42 APE67-dihe-in -65.93, -19.72 -128.13, -13.55 APE12-dist-out 21.5861 APE11-dist-out 23.3947 APE10-dist-out 17.5245 APE9-dist-out 12.17 None None None XRAY 2.4 0.217 0.254 A 366.0 348.0 0 25 25 0 [[24, 308]] 1.0 1m7q Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1OUKA Q16539 4 351 360.0 084:501 Type1 Inactive DFGin 8.0216 16.4531 BLBminus -120.29, 176.37 71.71, 79.23 -115.84, 130.78 281.72, 116.29 65.14, 27.27 in-in in 9.5643 Saltbr-in 3.1687 HRD-in -64.07, -50.96 81.29, -14.69 in-out-out SNCioo out-out ActLoopNT-out 11.5974 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -120.43, 138.52 APE9-dihe-na -60.72, -20.24 APE8-dihe-out -66.76, -17.57 APE8-rot-out 43.24 APE67-dihe-in -61.59, -23.16 -114.27, -15.3 APE12-dist-out 21.6434 APE11-dist-out 23.4239 APE10-dist-out 17.5306 APE9-dist-out 12.4759 None None None XRAY 2.5 0.217 0.264 A 366.0 348.0 0 25 25 0 [[24, 308]] 1.0 1ouk Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1OUYA Q16539 4 353 360.0 094:501 Type1 Inactive DFGin 8.0014 16.4672 BLBminus -127.01, 172.02 70.13, 95.72 -131.26, 146.15 281.74, 107.1 57.3, 32.52 in-in in 9.4127 Saltbr-in 2.9854 HRD-in -74.27, -49.28 73.36, -15.55 in-out-out SNCioo out-out ActLoopNT-out 11.3049 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -118.35, 133.85 APE9-dihe-na -63.2, -4.09 APE8-dihe-out -79.22, -6.55 APE8-rot-out 71.77 APE67-dihe-in -52.87, -23.93 -119.38, -25.62 APE12-dist-out 21.4677 APE11-dist-out 23.3589 APE10-dist-out 17.4767 APE9-dist-out 12.2091 None None None XRAY 2.5 0.226 0.256 A 366.0 350.0 0 25 25 0 [[24, 308]] 1.0 1ouy Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1YQJA Q16539 2 352 360.0 6NP:60362 Type1 Inactive DFGin 7.3287 16.1083 BLBminus -138.77, -163.86 37.6, 61.55 -60.11, 143.61 296.61, 65.49 -86.45, 47.76 in-out in 9.888 Saltbr-out 4.3044 HRD-in -61.71, -56.56 82.56, -22.38 out-out-out SNCooo out-out ActLoopNT-out 10.1615 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -129.58, 136.01 APE9-dihe-na -64.08, -20.19 APE8-dihe-out -62.87, -14.41 APE8-rot-out 51.35 APE67-dihe-in -61.66, -22.34 -117.68, -17.48 APE12-dist-out 22.1904 APE11-dist-out 24.3938 APE10-dist-out 18.7333 APE9-dist-out 11.9298 None None None XRAY 2.0 0.205 0.257 A 366.0 351.0 0 25 25 0 [[24, 308]] 1.0 1yqj Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ZYAA Q16539 1 353 360.0 2A8:60400 Type1 Inactive DFGin 6.9161 15.6674 BLBminus -120.67, 153.65 52.28, 73.55 -57.04, 142.46 306.58, 150.01 -77.06, 179.75 out-in out 10.0107 Saltbr-in 3.0905 HRD-in -69.11, -55.81 83.28, -17.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 14.11 APE8-dihe-out -74.11, -29.92 APE8-rot-out 58.3 APE67-dihe-in -66.06, -20.49 -108.78, -11.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3841 None None None XRAY 1.9 0.172 0.209 A 366.0 341.0 12 25 13 12 [[24, 308]] 1.0 3zya Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1OZ1A Q16539 5 352 360.0 FPH:500 Type1 Inactive DFGin 8.2109 17.0634 BLBminus -114.16, 172.08 85.44, 88.77 -133.96, 133.95 284.79, 95.76 65.21, 19.9 in-in in 9.511 Saltbr-in 2.5307 HRD-in -66.15, -54.29 77.91, -14.08 in-out-out SNCioo out-out ActLoopNT-out 11.5356 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.9, 134.09 APE9-dihe-na -64.8, -17.47 APE8-dihe-out -61.1, -18.06 APE8-rot-out 58.91 APE67-dihe-in -61.43, -23.68 -115.97, -17.25 APE12-dist-out 21.583 APE11-dist-out 23.4406 APE10-dist-out 17.5936 APE9-dist-out 11.826 None None None XRAY 2.1 0.204 0.251 A 372.0 344.0 4 25 25 0 [[24, 308]] 1.0 1oz1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FLQA Q16539 4 352 360.0 891:361 Type1 Inactive DFGin 8.3047 16.7597 BLBminus -114.5, 174.13 79.93, 71.12 -113.07, 140.32 283.22, 109.18 72.54, 15.24 in-in in 9.1526 Saltbr-in 2.5388 HRD-in -68.62, -54.92 81.05, -20.42 in-out-out SNCioo out-out ActLoopNT-out 10.6966 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.83, 134.4 APE9-dihe-na -61.43, -21.08 APE8-dihe-out -63.2, -18.72 APE8-rot-out 68.98 APE67-dihe-in -64.73, -17.91 -116.21, -18.71 APE12-dist-out 21.2413 APE11-dist-out 23.0908 APE10-dist-out 17.2616 APE9-dist-out 11.6901 None None None XRAY 1.9 0.235 0.275 A 372.0 345.0 4 25 25 0 [[24, 308]] 1.0 3flq Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FMJA Q16539 4 352 360.0 FMJ:361 Type1 Inactive DFGin 7.6822 16.6353 BLBminus -119.99, 177.68 52.9, 58.7 -54.87, 149.87 287.37, 61.96 -90.97, 999.0 in-in in 9.3617 Saltbr-in 2.5771 HRD-in -67.72, -48.76 77.48, -19.13 in-out-out SNCioo out-out ActLoopNT-out 10.8603 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -135.4, 132.7 APE9-dihe-na -58.69, -22.38 APE8-dihe-out -61.41, -17.71 APE8-rot-out 63.25 APE67-dihe-in -62.27, -20.19 -116.89, -20.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7599 None None None XRAY 2.0 0.217 0.268 A 372.0 344.0 5 25 23 2 [[24, 308]] 1.0 3fmj Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FSFA Q16539 5 352 360.0 FSS:450 Type1 Inactive DFGin 7.5209 16.559 BLBminus -126.93, 179.76 39.65, 72.67 -65.36, 151.92 292.97, 66.55 -17.25, 999.0 in-in in 9.4333 Saltbr-in 2.6944 HRD-in -59.58, -53.1 75.06, -9.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.46, 135.81 APE9-dihe-na -64.88, -14.68 APE8-dihe-out -66.01, -18.5 APE8-rot-out 44.13 APE67-dihe-in -59.72, -21.22 -117.36, -17.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9281 None None None XRAY 2.1 0.225 0.259 A 372.0 340.0 8 25 22 3 [[24, 308]] 1.0 3fsf Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1A9UA Q16539 4 354 360.0 SB2:800 Type1 Inactive DFGin 7.5045 16.7941 BLBminus -114.41, -166.13 12.94, 87.82 -68.23, 136.53 280.46, 77.71 -65.57, -40.4 in-in in 9.698 Saltbr-in 2.7381 HRD-in -62.88, -52.08 77.6, -12.91 in-out-out SNCioo out-out ActLoopNT-out 9.8282 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.45, 130.72 APE9-dihe-na -61.08, -19.54 APE8-dihe-out -64.32, -8.61 APE8-rot-out 46.86 APE67-dihe-in -65.16, -15.35 -123.62, -15.84 APE12-dist-out 22.8835 APE11-dist-out 24.7998 APE10-dist-out 19.2982 APE9-dist-out 11.7286 None None None XRAY 2.5 0.182 0.24 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1a9u Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1BL6A Q16539 4 354 360.0 SB6:800 Type1 Inactive DFGin 7.4564 16.538 BLBminus -145.17, -172.57 51.82, 52.45 -53.54, 141.28 284.57, 66.27 -55.43, -57.86 in-in in 9.5893 Saltbr-in 2.8675 HRD-in -51.96, -53.43 79.64, -20.23 in-out-out SNCioo out-out ActLoopNT-out 9.9548 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -123.42, 132.07 APE9-dihe-na -58.07, -30.56 APE8-dihe-out -55.1, -34.56 APE8-rot-out 71.27 APE67-dihe-in -61.14, -14.61 -91.38, -21.67 APE12-dist-out 22.7877 APE11-dist-out 24.7944 APE10-dist-out 19.0587 APE9-dist-out 11.945 None None None XRAY 2.5 0.185 0.251 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1bl6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1BL7A Q16539 4 354 360.0 SB4:800 Type1 Inactive DFGin 7.9115 16.7904 BLBminus -135.76, -164.94 45.19, 53.1 -57.31, 172.61 275.72, 65.22 -88.08, -57.25 in-in in 9.2873 Saltbr-in 2.8625 HRD-in -59.74, -47.17 76.3, -19.18 in-out-out SNCioo out-out ActLoopNT-out 10.14 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -120.45, 132.04 APE9-dihe-na -67.19, -14.66 APE8-dihe-out -66.31, -16.07 APE8-rot-out 63.68 APE67-dihe-in -59.41, -12.41 -116.23, -18.86 APE12-dist-out 23.8221 APE11-dist-out 25.9511 APE10-dist-out 20.1481 APE9-dist-out 11.8911 None None None XRAY 2.5 0.193 0.265 A 379.0 351.0 0 25 25 0 [[24, 308]] 1.0 1bl7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MPAA Q16539 5 352 360.0 SB2:361 Type1 Inactive DFGin 7.2743 15.3554 BLBminus -133.49, -165.87 57.46, 46.09 -54.73, 150.67 290.61, 74.17 -42.79, 999.0 in-in in 9.1984 Saltbr-in 2.6173 HRD-in -72.56, -50.67 81.89, -14.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 167.3 APE8-rot-in 334.53 APE67-dihe-in -58.8, -27.47 -62.95, -13.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D168G None None XRAY 2.1 0.235 0.289 A 360.0 331.0 17 25 11 14 [[24, 308]] 1.0 3mpa Homo sapiens CMGC_MAPK14_HUMAN CMGC 2.7e-83 285.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2ZB1A Q16539 4 352 360.0 GK4:361 Type1.5_Back Inactive DFGin 7.3325 15.632 BLBminus -130.35, 170.65 45.65, 69.72 -60.48, 135.77 297.96, 80.44 -60.1, 109.16 in-in in 9.1642 Saltbr-in 2.6702 HRD-in -61.25, -52.64 82.49, -17.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -142.2, 137.03 APE9-dihe-na -61.77, -22.73 APE8-dihe-out -57.45, -25.09 APE8-rot-out 52.04 APE67-dihe-in -64.0, -18.53 -113.02, -16.57 APE12-dist-out 21.888 APE11-dist-out 23.8985 APE10-dist-out 18.2966 APE9-dist-out 11.7672 None None None XRAY 2.5 0.172 0.239 A 360.0 345.0 4 25 23 2 [[24, 308]] 1.0 2zb1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5XYXA Q16539 4 353 360.0 FTZ:401 Type1.5_Back Inactive DFGin 8.2729 16.6397 BLBminus -116.2, 173.45 58.06, 87.28 -116.16, 154.24 295.44, 84.66 106.17, 999.0 in-in in 9.2714 Saltbr-in 3.1201 HRD-in -67.68, -47.02 80.87, -18.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -138.98, 135.51 APE9-dihe-na -62.25, -22.13 APE8-dihe-out -61.23, -15.58 APE8-rot-out 46.35 APE67-dihe-in -54.77, -26.55 -120.61, -19.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7398 None None None XRAY 2.61 0.218 0.26 A 380.0 337.0 13 25 22 3 [[24, 308]] 1.0 5xyx Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5XYYA Q16539 4 352 360.0 P0F:401 Type1.5_Back Inactive DFGin 8.1438 16.2502 BLBminus -111.25, 174.05 61.59, 81.71 -109.03, 145.8 286.82, 89.51 69.26, 21.62 in-in in 8.942 Saltbr-in 2.6487 HRD-in -68.14, -52.86 82.9, -10.64 in-out-out SNCioo out-out ActLoopNT-out 11.4762 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 131.59 APE9-dihe-na -62.4, -17.36 APE8-dihe-out -62.41, -19.09 APE8-rot-out 53.75 APE67-dihe-in -64.55, -20.22 -114.48, -18.89 APE12-dist-out 21.1385 APE11-dist-out 22.895 APE10-dist-out 17.0927 APE9-dist-out 11.7589 None None None XRAY 1.7 0.18 0.201 A 380.0 343.0 6 25 25 0 [[24, 308]] 1.0 5xyy Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3NEWA Q16539 5 352 360.0 3NE:361 Allosteric Inactive DFGin 5.3779 13.1071 BLBplus -114.35, 171.8 67.6, 14.1 -53.7, 162.04 18.33, 63.1 61.74, -33.29 in-in in 9.5103 Saltbr-in 3.0638 HRD-in -60.9, -56.32 86.26, -12.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -44.22 APE8-rot-out 178.97 APE67-dihe-in -72.83, -20.41 -64.21, -12.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C162S None None XRAY 2.51 0.219 0.306 A 366.0 334.0 14 25 13 12 [[24, 308]] 1.0 3new Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH2A Q16539 4 354 360.0 IRG:401,0OK:402 Allosteric,Type1 Inactive DFGin 5.0488 13.9493 BLBplus -117.8, 162.51 72.3, 21.2 -57.69, 163.34 31.01, 95.16 92.75, 999.0 in-in in 9.39 Saltbr-in 2.9127 HRD-in -68.61, -52.99 79.87, -17.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 104.22 APE9-dihe-na -64.21, 119.38 APE8-dihe-out -37.73, -46.13 APE8-rot-in 267.35 APE67-dihe-in -65.75, -23.42 -54.51, -28.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4245 None None None XRAY 2.0 0.226 0.274 A 360.0 337.0 14 25 13 12 [[24, 308]] 1.0 4eh2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MH2A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 5.1833 14.4282 BLBplus -108.45, 150.31 80.55, 9.3 -51.09, 147.78 31.6, 88.92 52.72, 999.0 in-out in 9.4616 Saltbr-out 4.1349 HRD-in -87.39, -52.66 84.79, -12.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.3 APE8-rot-in 266.2 APE67-dihe-in -62.25, -28.76 -55.01, -18.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169Y None None XRAY 2.3 0.247 0.318 A 360.0 330.0 18 25 11 14 [[24, 308]] 1.0 3mh2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.3e-84 288.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5ETIA Q16539 1 352 360.0 No_ligand No_ligand Inactive DFGin 5.1472 15.4196 BLBplus -119.94, 157.71 69.48, 37.44 -94.83, 139.77 47.07, 94.27 84.3, 5.93 out-none out 10.4335 Saltbr-none 999.0 HRD-in -63.44, -44.0 71.3, -9.39 none-out-out SNCnoo out-out ActLoopNT-out 9.8512 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -125.74, 141.21 APE9-dihe-na -73.47, -31.47 APE8-dihe-out -54.4, -47.64 APE8-rot-out 66.16 APE67-dihe-in -68.53, -25.27 -76.41, -12.45 APE12-dist-out 22.6357 APE11-dist-out 24.4655 APE10-dist-out 18.731 APE9-dist-out 12.2405 None None None XRAY 2.8 0.178 0.225 A 366.0 352.0 0 25 25 0 [[24, 308]] 1.0 5eti Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FI4A Q16539 4 352 360.0 FI4:361 Type1 Inactive DFGin 4.8677 13.6797 BLBplus -116.8, 163.07 65.52, 26.76 -74.81, 149.05 43.11, 82.7 76.87, 6.14 in-in in 9.1105 Saltbr-in 2.6886 HRD-in -60.69, -54.78 85.32, -23.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.35, 135.44 APE9-dihe-na -63.33, -14.63 APE8-dihe-out -67.74, -19.61 APE8-rot-out 60.23 APE67-dihe-in -67.68, -20.67 -113.25, -13.01 APE12-dist-out 22.0872 APE11-dist-out 24.1413 APE10-dist-out 18.5028 APE9-dist-out 12.422 R57K None None XRAY 2.2 0.212 0.238 A 372.0 339.0 10 25 22 3 [[24, 308]] 1.0 3fi4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FKOA Q16539 5 352 360.0 FKO:361 Type1 Inactive DFGin 4.6607 13.622 BLBplus -111.44, 157.26 69.44, 28.26 -72.66, 144.44 41.0, 85.24 70.05, 9.98 in-in in 9.1244 Saltbr-in 2.7159 HRD-in -66.96, -53.75 82.74, -20.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.91, 131.16 APE9-dihe-na -61.2, -20.43 APE8-dihe-out -61.86, -23.05 APE8-rot-out 54.03 APE67-dihe-in -63.55, -20.16 -111.23, -16.8 APE12-dist-out 22.0249 APE11-dist-out 24.0109 APE10-dist-out 18.3061 APE9-dist-out 12.0648 R57K None None XRAY 2.0 0.216 0.253 A 372.0 343.0 5 25 22 3 [[24, 308]] 1.0 3fko Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FLNC Q16539 3 352 360.0 3FN:361 Type1 Inactive DFGin 4.8948 13.7477 BLBplus -105.05, 155.94 66.04, 26.04 -70.99, 147.16 45.83, 89.7 76.23, 8.94 in-in in 9.083 Saltbr-in 2.599 HRD-in -67.49, -56.85 81.97, -18.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.61, 135.31 APE9-dihe-na -58.39, -20.63 APE8-dihe-out -64.51, -18.59 APE8-rot-out 57.49 APE67-dihe-in -63.96, -19.95 -115.78, -17.1 APE12-dist-out 22.2434 APE11-dist-out 24.3235 APE10-dist-out 18.6659 APE9-dist-out 12.1947 R57K None None XRAY 1.9 0.211 0.234 C 372.0 343.0 7 25 22 3 [[24, 308]] 1.0 3fln Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6OHDA Q16539 4 352 360.0 MKP:900 Type1 Inactive DFGin 5.0309 13.9055 BLBplus -118.15, 159.21 60.76, 27.76 -70.47, 137.41 41.69, 89.07 66.92, 13.52 in-in in 8.8085 Saltbr-in 2.5408 HRD-in -71.28, -47.06 75.25, -20.9 in-out-out SNCioo out-out ActLoopNT-out 8.1396 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.41 APE8-dihe-in -86.7, 134.65 APE8-rot-out 60.91 APE67-dihe-out -71.49, -18.04 -120.56, 61.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2954 None None None XRAY 2.5 0.213 0.253 A 388.0 330.0 19 25 15 10 [[24, 308]] 1.0 6ohd Homo sapiens CMGC_MAPK14_HUMAN CMGC 1e-84 290.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1OVEA Q16539 4 352 360.0 358:401 Type1 Inactive DFGin 4.8066 13.4784 BLBplus -131.9, 174.28 62.22, 23.86 -68.64, 149.36 35.73, 74.72 53.78, 19.07 in-in in 9.1333 Saltbr-in 2.8284 HRD-in -65.96, -52.49 68.25, -0.6 in-out-out SNCioo out-out ActLoopNT-out 9.8879 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.51, 133.59 APE9-dihe-na -56.38, -21.28 APE8-dihe-out -65.12, -19.35 APE8-rot-out 55.52 APE67-dihe-in -65.18, -20.01 -115.17, -13.18 APE12-dist-out 21.7467 APE11-dist-out 23.6988 APE10-dist-out 18.0885 APE9-dist-out 12.27 C162S None None XRAY 2.1 0.195 0.233 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 1ove Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GC7A Q16539 4 352 360.0 B45:361 Type1 Inactive DFGin 6.8914 15.6924 BLBplus -130.29, -178.32 55.87, 56.48 -136.93, 164.81 70.99, 105.71 67.06, 10.11 in-in in 9.1173 Saltbr-in 2.6265 HRD-in -64.07, -56.2 85.52, -15.66 in-out-out SNCioo out-out ActLoopNT-out 10.363 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.45, 132.85 APE9-dihe-na -61.59, -21.21 APE8-dihe-out -58.27, -23.47 APE8-rot-out 53.22 APE67-dihe-in -60.64, -23.63 -113.11, -23.09 APE12-dist-out 22.1523 APE11-dist-out 24.1078 APE10-dist-out 18.3509 APE9-dist-out 11.736 C162S None None XRAY 1.8 0.182 0.208 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3gc7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3S3IA Q16539 4 352 360.0 CQ0:1 Type1 Inactive DFGin 5.3256 14.0492 BLBplus -112.59, 160.38 67.13, 22.49 -69.88, 149.56 37.18, 83.84 76.62, -7.09 in-in in 8.7644 Saltbr-in 2.8788 HRD-in -59.53, -53.41 62.43, -11.33 in-out-out SNCioo out-out ActLoopNT-out 9.2592 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.32, 136.07 APE9-dihe-na -59.08, -17.33 APE8-dihe-out -61.43, -18.71 APE8-rot-out 56.9 APE67-dihe-in -67.37, -22.1 -117.88, -13.71 APE12-dist-out 22.2177 APE11-dist-out 24.2199 APE10-dist-out 18.633 APE9-dist-out 11.8861 None None None XRAY 1.8 0.233 0.258 A 349.0 349.0 0 25 25 0 [[24, 308]] 1.0 3s3i Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.3e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1ZZLA Q16539 4 354 360.0 TZY:999 Type1 Inactive DFGin 4.733 13.8577 BLBplus -103.73, 163.26 58.07, 31.2 -75.39, 145.77 47.84, 82.21 65.87, 14.85 in-in in 9.2813 Saltbr-in 2.7803 HRD-in -61.64, -58.85 81.18, -19.72 in-out-out SNCioo out-out ActLoopNT-out 10.1664 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -129.62, 134.13 APE9-dihe-na -60.4, -25.87 APE8-dihe-out -57.07, -14.53 APE8-rot-out 52.9 APE67-dihe-in -72.53, -14.8 -116.88, -15.6 APE12-dist-out 22.3703 APE11-dist-out 24.2829 APE10-dist-out 18.6041 APE9-dist-out 12.1132 None None None XRAY 2.0 0.222 0.273 A 351.0 351.0 0 25 25 0 [[24, 308]] 1.0 1zzl Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.4e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2YIXA Q16539 4 354 360.0 YIX:1355 Type1 Inactive DFGin 5.0897 14.1287 BLBplus -114.65, 158.99 60.01, 31.87 -79.41, 149.6 45.27, 82.7 60.63, 15.85 in-in in 9.0535 Saltbr-in 2.9319 HRD-in -69.82, -59.44 74.29, -12.91 in-out-out SNCioo out-out ActLoopNT-out 10.057 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -127.34, 129.67 APE9-dihe-na -56.26, -30.86 APE8-dihe-out -60.88, -7.51 APE8-rot-out 59.88 APE67-dihe-in -61.17, -20.41 -120.93, -20.74 APE12-dist-out 22.8344 APE11-dist-out 24.8622 APE10-dist-out 19.0628 APE9-dist-out 11.9454 None None None XRAY 2.3 0.196 0.247 A 351.0 351.0 0 25 25 0 [[24, 308]] 1.0 2yix Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.4e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HRBA Q16539 4 352 360.0 I39:1 Type1 Inactive DFGin 4.7404 13.6096 BLBplus -109.68, 159.67 59.92, 25.46 -66.38, 138.28 43.11, 80.53 88.39, -1.65 in-in in 9.0933 Saltbr-in 2.879 HRD-in -67.07, -57.02 74.91, -12.94 in-out-out SNCioo out-out ActLoopNT-out 9.9671 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.19, 133.67 APE9-dihe-na -54.16, -26.74 APE8-dihe-out -60.77, -19.94 APE8-rot-out 56.69 APE67-dihe-in -72.75, -14.91 -115.4, -11.3 APE12-dist-out 21.8484 APE11-dist-out 23.8887 APE10-dist-out 18.2084 APE9-dist-out 12.2655 None None None XRAY 2.2 0.217 0.26 A 359.0 344.0 5 25 25 0 [[24, 308]] 1.0 3hrb Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1ZYJA Q16539 5 352 360.0 BI5:362 Type1 Inactive DFGin 5.1963 13.7975 BLBplus -112.41, 162.76 46.48, 45.87 -86.82, 159.02 43.68, 86.73 65.25, 17.57 in-in in 9.195 Saltbr-in 2.5852 HRD-in -65.9, -54.22 81.4, -15.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 174.12 APE8-rot-in 323.47 APE67-dihe-in -61.35, -24.56 -115.26, 1.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.268 0.267 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 1zyj Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1ZZ2A Q16539 5 352 360.0 B11:362 Type1 Inactive DFGin 5.3394 13.9578 BLBplus -120.85, 149.07 49.89, 48.28 -88.35, 160.53 50.56, 89.91 68.41, 12.43 in-in in 8.7319 Saltbr-in 2.7767 HRD-in -68.3, -55.12 66.46, 3.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.5 APE8-dihe-out -58.95, -37.15 APE8-rot-in 275.96 APE67-dihe-in -50.5, -32.48 -55.76, -39.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5468 None None None XRAY 2.0 0.262 0.29 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 1zz2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2ZAZA Q16539 4 352 360.0 GK1:362 Type1 Inactive DFGin 7.3994 15.9398 BLBplus -115.23, 176.01 60.89, 77.69 -123.12, 161.77 6.94, 26.13 78.38, 12.21 in-in in 9.4181 Saltbr-in 2.6795 HRD-in -66.73, -53.6 82.05, -15.76 in-out-out SNCioo out-out ActLoopNT-out 11.3262 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 133.41 APE9-dihe-na -61.36, -17.74 APE8-dihe-out -62.47, -15.93 APE8-rot-out 52.34 APE67-dihe-in -63.58, -18.92 -121.06, -15.96 APE12-dist-out 21.2963 APE11-dist-out 23.1344 APE10-dist-out 17.2671 APE9-dist-out 11.7778 None None None XRAY 1.8 0.199 0.234 A 360.0 345.0 4 25 25 0 [[24, 308]] 1.0 2zaz Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3D7ZA Q16539 4 352 360.0 GK5:401 Type1 Inactive DFGin 5.4719 13.9052 BLBplus -110.05, 159.12 71.33, 19.43 -70.41, 155.49 43.03, 84.34 62.35, 11.69 in-in in 8.6765 Saltbr-in 2.588 HRD-in -70.59, -57.12 79.42, -20.6 in-out-out SNCioo out-out ActLoopNT-out 9.0845 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -139.41, 134.0 APE9-dihe-na -61.33, -22.23 APE8-dihe-out -58.46, -25.27 APE8-rot-out 52.6 APE67-dihe-in -66.01, -21.29 -109.77, -17.38 APE12-dist-out 22.308 APE11-dist-out 24.2828 APE10-dist-out 18.6655 APE9-dist-out 11.8802 None None CSO119 XRAY 2.1 0.177 0.227 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 3d7z Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3IPHA Q16539 4 352 360.0 G11:361 Type1 Inactive DFGin 5.8072 14.1611 BLBplus -118.73, 162.65 67.18, 18.11 -71.69, 160.43 43.35, 83.27 65.65, 15.53 in-in in 8.7563 Saltbr-in 2.6906 HRD-in -74.71, -57.61 79.14, -23.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -144.35, 133.12 APE9-dihe-na -56.61, -21.99 APE8-dihe-out -64.41, -16.18 APE8-rot-out 54.9 APE67-dihe-in -64.39, -19.25 -118.43, -15.06 APE12-dist-out 22.3267 APE11-dist-out 24.2942 APE10-dist-out 18.8533 APE9-dist-out 11.648 None None CSO119,CSO162 XRAY 2.1 0.184 0.249 A 360.0 347.0 2 25 23 2 [[24, 308]] 1.0 3iph Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3KF7A Q16539 5 352 360.0 L9G:60401 Type1 Inactive DFGin 5.1086 13.1627 BLBplus -108.18, 151.36 65.29, 12.11 -35.39, 152.89 38.26, 90.38 72.15, -32.28 in-in in 9.0328 Saltbr-in 2.8286 HRD-in -67.37, -53.91 79.87, -15.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 60.06 APE9-dihe-na -69.4, 135.81 APE8-dihe-out -55.41, -37.65 APE8-rot-none 999.0 APE67-dihe-in -61.12, -27.93 -46.48, -41.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.6647 APE9-dist-out 10.9338 None None None XRAY 2.0 0.235 0.274 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3kf7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3RINA Q16539 4 352 360.0 I2O:401 Type1 Inactive DFGin 5.0815 13.6204 BLBplus -114.0, 158.6 70.65, 16.99 -65.1, 140.89 33.49, 80.3 69.95, 1.93 in-in in 8.9372 Saltbr-in 2.9241 HRD-in -55.11, -53.67 73.84, -19.05 in-out-out SNCioo out-out ActLoopNT-out 9.7945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.29, 128.8 APE9-dihe-na -57.87, -15.63 APE8-dihe-out -75.69, 1.27 APE8-rot-out 82.63 APE67-dihe-in -61.25, -17.28 -132.79, -15.39 APE12-dist-out 21.9743 APE11-dist-out 23.8177 APE10-dist-out 18.1676 APE9-dist-out 12.0826 None None None XRAY 2.2 0.265 0.308 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 3rin Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5MTXA Q16539 5 352 360.0 FJI:401 Type1 Inactive DFGin 5.4582 14.136 BLBplus -112.91, 158.05 62.91, 38.11 -88.92, 163.57 43.19, 91.49 71.06, 5.17 in-in in 8.9094 Saltbr-in 2.7487 HRD-in -70.36, -56.47 76.64, -11.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.61 APE8-rot-out 184.43 APE67-dihe-in -61.4, -22.03 -104.95, 4.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.191 0.233 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 5mtx Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5MTYA Q16539 5 352 360.0 HB9:401 Type1 Inactive DFGin 5.7438 14.0709 BLBplus -117.73, 163.81 48.17, 40.91 -75.75, 165.15 37.67, 90.02 34.98, 999.0 in-in in 8.8783 Saltbr-in 2.8604 HRD-in -72.44, -55.72 86.74, -19.51 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.18 APE8-rot-in 291.54 APE67-dihe-in -71.41, -22.48 -112.24, 10.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.271 A 360.0 328.0 20 25 11 14 [[24, 308]] 1.0 5mty Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5TBEA Q16539 5 353 360.0 78L:401 Type1 Inactive DFGin 6.4774 14.8835 BLBplus -93.8, 144.39 61.93, 30.09 -73.07, 151.97 64.35, 85.26 84.23, 2.96 in-in in 9.1049 Saltbr-in 2.654 HRD-in -76.42, -61.38 82.77, -33.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.07, -13.0 999.0, -13.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.44 0.189 0.254 A 360.0 332.0 17 25 12 13 [[24, 308]] 1.0 5tbe Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9Y8BA Q16539 5 353 360.0 A1CTD:402 Type1 Inactive DFGin 4.6239 13.7198 BLBplus -109.52, 154.53 68.6, 22.27 -61.66, 145.35 41.31, 108.5 67.82, 16.21 in-in in 9.5503 Saltbr-in 2.6796 HRD-in -68.81, -56.85 82.39, -13.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.28 APE8-dihe-in -125.2, 155.55 APE8-rot-out 54.38 APE67-dihe-out -71.64, -13.87 -27.27, 104.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 15.6486 None None None XRAY 1.97 0.183 0.221 A 360.0 338.0 11 25 14 11 [[24, 308]] 1.0 9y8b Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5TCOA Q16539 6 352 360.0 79Q:401 Type1 Inactive DFGin 5.2616 14.1159 BLBplus -107.56, 157.64 61.22, 34.19 -83.48, 153.07 46.33, 88.09 65.12, 36.29 in-in in 8.7421 Saltbr-in 2.7328 HRD-in -80.38, -60.51 87.12, -16.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -43.63 APE8-rot-in 285.59 APE67-dihe-in -62.06, -23.45 -95.94, 3.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.217 0.27 A 360.0 327.0 20 25 12 13 [[24, 308]] 1.0 5tco Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9Q5BA Q16539 5 353 360.0 A1CRZ:402 Type1 Inactive DFGin 4.8761 13.5709 BLBplus -103.71, 161.3 50.9, 30.92 -62.56, 151.06 41.69, 95.46 46.76, 33.42 in-in in 9.4764 Saltbr-in 2.8269 HRD-in -72.21, -56.01 76.62, -12.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.15 APE8-dihe-out -62.65, -30.96 APE8-rot-out 172.83 APE67-dihe-in -64.1, -23.31 -55.81, -28.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6399 None None CME162 XRAY 2.05 0.193 0.236 A 362.0 333.0 16 25 13 12 [[24, 308]] 1.0 9q5b Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6M9LA Q16539 5 352 360.0 J9G:501 Type1 Inactive DFGin 5.0139 13.2894 BLBplus -126.64, 146.45 61.95, 34.85 -65.96, 149.32 34.74, 88.86 64.07, 999.0 in-in in 8.8657 Saltbr-in 2.9824 HRD-in -71.33, -38.03 72.28, -19.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.78 APE8-rot-out 177.34 APE67-dihe-in -76.69, -14.09 -105.81, 3.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.216 0.27 A 388.0 331.0 17 25 11 14 [[24, 308]] 1.0 6m9l Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-84 289.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3DS6A Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.3658 14.6548 BLBplus -122.93, 172.79 47.41, 37.04 -83.59, 151.14 48.87, 79.98 61.26, 21.03 in-in in 9.7737 Saltbr-in 3.0728 HRD-in -72.1, -49.23 78.27, -31.31 in-out-out SNCioo out-out ActLoopNT-out 9.2636 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -164.1 APE9-dihe-na 70.58, 125.16 APE8-dihe-in -55.31, 146.03 APE8-rot-out 71.52 APE67-dihe-in -65.93, -10.4 -130.08, 13.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.6227 APE9-dist-out 10.3084 None None None XRAY 2.9 0.228 0.319 A 366.0 343.0 6 25 19 6 [[24, 308]] 1.0 3ds6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3DS6B Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.4731 14.4755 BLBplus -123.62, 166.77 55.02, 30.8 -85.61, 160.65 52.06, 76.39 59.15, 32.95 in-in in 9.0027 Saltbr-in 2.82 HRD-in -80.61, -61.75 77.29, 8.66 in-out-out SNCioo out-out ActLoopNT-out 9.3691 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 142.95 APE9-dihe-na 79.62, 112.64 APE8-dihe-in -54.08, 137.84 APE8-rot-out 77.26 APE67-dihe-in -52.14, -19.33 -111.76, 8.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4367 APE9-dist-out 10.1017 None None None XRAY 2.9 0.228 0.319 B 366.0 343.0 6 25 19 6 [[24, 308]] 1.0 3ds6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3DS6C Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.9833 14.4693 BLBplus -127.13, 170.87 50.14, 37.25 -87.87, 170.72 41.22, 87.61 57.99, 29.61 in-in in 8.8118 Saltbr-in 3.0637 HRD-in -66.29, -53.6 81.12, -16.31 in-out-out SNCioo out-out ActLoopNT-out 8.8576 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -56.14, 143.7 APE9-dihe-na -91.25, 29.56 APE8-dihe-out -111.78, 23.16 APE8-rot-out 74.82 APE67-dihe-in -64.75, -24.89 -135.72, -8.12 APE12-dist-out 21.2133 APE11-dist-out 22.9514 APE10-dist-out 17.083 APE9-dist-out 12.4953 None None None XRAY 2.9 0.228 0.319 C 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3ds6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3DS6D Q16539 4 352 360.0 A17:361 Type1 Inactive DFGin 5.2401 14.4797 BLBplus -127.49, 166.91 61.08, 14.93 -65.95, 148.58 51.55, 94.54 79.43, 72.03 in-in in 9.5006 Saltbr-in 3.1285 HRD-in -80.05, -51.35 75.1, -31.54 in-out-out SNCioo out-out ActLoopNT-out 10.1352 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.1, 162.6 APE9-dihe-na 76.6, -149.02 APE8-dihe-in -151.85, 111.76 APE8-rot-out 41.83 APE67-dihe-in -38.68, -38.29 -96.24, -18.63 APE12-dist-out 18.9801 APE11-dist-out 20.1236 APE10-dist-out 15.9022 APE9-dist-out 10.8817 None None None XRAY 2.9 0.228 0.319 D 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3ds6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GFEA Q16539 1 352 360.0 P37:361 Type1 Inactive DFGin 5.1879 13.8082 BLBplus -115.86, 165.88 67.19, 19.31 -64.73, 142.19 40.91, 86.55 76.47, 0.22 in-in in 8.7663 Saltbr-in 2.6838 HRD-in -66.42, -56.03 78.03, -8.83 in-out-out SNCioo out-out ActLoopNT-out 10.3917 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.92, 132.97 APE9-dihe-na -62.32, -20.23 APE8-dihe-out -60.82, -21.97 APE8-rot-out 57.38 APE67-dihe-in -61.5, -24.14 -110.53, -18.99 APE12-dist-out 22.291 APE11-dist-out 24.2092 APE10-dist-out 18.4964 APE9-dist-out 12.4045 None None None XRAY 2.1 0.218 0.25 A 366.0 352.0 0 25 25 0 [[24, 308]] 1.0 3gfe Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ITZA Q16539 1 353 360.0 P66:60401 Type1 Inactive DFGin 4.9585 13.9183 BLBplus -107.9, 162.3 63.06, 31.58 -72.36, 146.38 38.16, 83.23 67.02, 10.18 in-in in 9.1003 Saltbr-in 2.7241 HRD-in -69.01, -57.02 88.24, -30.51 in-out-out SNCioo out-out ActLoopNT-out 10.0916 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.42, 134.26 APE9-dihe-na -58.35, -29.26 APE8-dihe-out -54.12, -23.64 APE8-rot-out 64.73 APE67-dihe-in -59.15, -23.05 -112.8, -19.77 APE12-dist-out 22.4167 APE11-dist-out 24.3629 APE10-dist-out 18.6782 APE9-dist-out 12.2003 None None None XRAY 2.25 0.216 0.249 A 366.0 353.0 0 25 25 0 [[24, 308]] 1.0 3itz Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LHJA Q16539 5 352 360.0 LHJ:361 Type1 Inactive DFGin 5.3359 13.8777 BLBplus -115.51, 163.31 63.03, 29.36 -80.13, 152.17 45.31, 85.49 71.44, 9.33 in-in in 8.9535 Saltbr-in 2.5974 HRD-in -75.58, -60.18 86.33, -20.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -125.96, 147.96 APE9-dihe-na -81.76, -12.73 APE8-dihe-out -71.4, -13.81 APE8-rot-out 58.36 APE67-dihe-in -65.64, -7.53 -102.09, -20.01 APE12-dist-out 21.8415 APE11-dist-out 23.9653 APE10-dist-out 18.2066 APE9-dist-out 12.6099 None None None XRAY 3.31 0.217 0.289 A 366.0 341.0 7 25 18 7 [[24, 308]] 1.0 3lhj Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3U8WA Q16539 4 352 360.0 09J:500 Type1 Inactive DFGin 5.002 14.1816 BLBplus -111.96, 165.8 69.87, 20.22 -68.93, 147.04 41.63, 87.6 71.46, 7.86 in-in in 8.9829 Saltbr-in 2.6753 HRD-in -69.12, -58.03 64.43, 7.59 in-out-out SNCioo out-out ActLoopNT-out 9.2818 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.78, 133.32 APE9-dihe-na -62.08, -21.59 APE8-dihe-out -57.48, -25.08 APE8-rot-out 54.07 APE67-dihe-in -63.09, -21.57 -110.32, -18.62 APE12-dist-out 21.8294 APE11-dist-out 23.851 APE10-dist-out 18.1713 APE9-dist-out 12.0393 None None None XRAY 2.15 0.235 0.255 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 3u8w Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2BALA Q16539 5 353 360.0 PQA:401 Type1 Inactive DFGin 5.065 13.8126 BLBplus -114.2, 157.25 64.96, 21.25 -58.19, 154.52 45.13, 93.16 67.4, 7.35 in-in in 8.9284 Saltbr-in 2.6678 HRD-in -66.82, -54.57 78.19, -14.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.42 APE8-dihe-out -62.64, -34.45 APE8-rot-out 221.94 APE67-dihe-in -60.27, -23.35 -60.34, -26.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8096 None None CSS162 XRAY 2.1 0.22 0.265 A 365.0 338.0 11 25 14 11 [[24, 308]] 1.0 2bal Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4AA4A Q16539 5 355 360.0 QC0:1356 Type1 Inactive DFGin 5.554 14.3889 BLBplus -110.75, 162.11 67.45, 15.6 -63.63, 154.39 40.31, 96.48 76.38, 8.0 in-in in 9.0234 Saltbr-in 2.685 HRD-in -62.75, -59.41 81.03, -20.48 in-out-out SNCioo out-out ActLoopNT-out 8.141 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -102.14, 114.46 APE9-dihe-na -82.19, 164.99 APE8-dihe-in -107.68, 123.81 APE8-rot-in 313.88 APE67-dihe-in -64.7, -21.49 -49.45, -47.92 APE12-dist-in 8.9325 APE11-dist-out 5.1054 APE10-dist-out 10.7388 APE9-dist-out 6.2572 None None None XRAY 2.3 0.214 0.255 A 365.0 347.0 4 25 25 0 [[24, 308]] 1.0 4aa4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4AA5A Q16539 5 352 360.0 NQB:1353 Type1 Inactive DFGin 5.8955 14.4336 BLBplus -115.01, 160.41 74.09, 14.28 -68.41, 156.78 48.17, 83.43 73.38, -0.15 in-in in 9.0239 Saltbr-in 2.5348 HRD-in -69.21, -57.74 77.98, -20.09 in-out-out SNCioo out-out ActLoopNT-out 8.2398 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -101.94, 113.07 APE9-dihe-na -84.46, 166.95 APE8-dihe-in -111.34, 114.37 APE8-rot-in 305.83 APE67-dihe-in -60.23, -23.5 -47.25, -45.26 APE12-dist-in 9.0301 APE11-dist-out 5.1957 APE10-dist-out 10.7506 APE9-dist-out 6.4779 None None CSS162 XRAY 2.38 0.218 0.26 A 365.0 341.0 7 25 22 3 [[24, 308]] 1.0 4aa5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4AACA Q16539 5 359 360.0 AAV:1360 Type1 Inactive DFGin 5.5863 14.7093 BLBplus -109.28, 158.52 65.37, 19.6 -65.62, 151.47 45.42, 91.42 69.1, 20.42 in-in in 8.8926 Saltbr-in 2.6681 HRD-in -58.62, -59.28 76.85, -14.52 in-out-out SNCioo out-out ActLoopNT-out 8.2565 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -96.42, 111.28 APE9-dihe-na -75.75, 165.33 APE8-dihe-in -110.09, 114.94 APE8-rot-in 304.67 APE67-dihe-in -70.87, -14.11 -43.79, -36.88 APE12-dist-in 8.974 APE11-dist-out 5.3396 APE10-dist-out 10.7909 APE9-dist-out 6.2814 None None None XRAY 2.5 0.234 0.305 A 365.0 350.0 5 25 25 0 [[24, 308]] 1.0 4aac Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2QD9A Q16539 5 352 360.0 LGF:361 Type1 Inactive DFGin 5.1343 13.7971 BLBplus -108.86, 148.96 74.79, 24.8 -73.05, 150.79 49.54, 82.76 82.07, 6.15 in-in in 9.155 Saltbr-in 2.5566 HRD-in -76.06, -55.95 78.8, -20.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.56, -22.52 999.0, -59.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.252 0.282 A 366.0 330.0 18 25 12 13 [[24, 308]] 1.0 2qd9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MVLA Q16539 5 353 360.0 38P:361 Type1 Inactive DFGin 5.9231 13.9396 BLBplus -119.06, 172.25 43.96, 31.01 -75.04, 165.39 47.04, 85.22 49.98, 13.01 in-in in 8.8486 Saltbr-in 2.5606 HRD-in -92.72, -54.18 74.73, 5.28 in-out-none SNCion out-none ActLoopNT-out 8.5019 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.46 APE8-rot-in 313.41 APE67-dihe-in -57.45, -35.22 -63.53, -26.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.335 A 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 3mvl Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MVLB Q16539 5 353 360.0 38P:361 Type1 Inactive DFGin 5.8783 14.202 BLBplus -107.75, 146.07 75.29, -5.13 -46.54, 143.19 54.91, 98.87 68.67, 7.96 in-in in 8.9821 Saltbr-in 2.6996 HRD-in -70.81, -51.73 77.53, -13.13 in-out-none SNCion out-none ActLoopNT-out 7.1992 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.44 APE8-rot-in 326.95 APE67-dihe-in -59.91, -44.52 -72.93, -14.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.335 B 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 3mvl Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MVMA Q16539 4 352 360.0 39P:361 Type1 Inactive DFGin 5.1124 14.6414 BLBplus -109.05, 158.07 60.08, 30.28 -73.72, 142.65 52.92, 91.21 70.7, -1.72 in-in in 9.0784 Saltbr-in 2.6241 HRD-in -63.63, -54.52 81.45, -25.37 in-out-out SNCioo out-out ActLoopNT-out 7.7603 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -96.85 APE8-rot-in 340.3 APE67-dihe-out -65.9, -21.64 122.83, -4.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.238 A 366.0 335.0 14 25 16 9 [[24, 308]] 1.0 3mvm Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MVMB Q16539 5 351 360.0 39P:361 Type1 Inactive DFGin 4.9534 14.5909 BLBplus -108.83, 159.13 58.86, 31.42 -73.06, 137.72 52.17, 94.17 71.9, 9.12 in-in in 9.0283 Saltbr-in 2.5452 HRD-in -63.09, -54.14 78.68, -22.23 in-out-out SNCioo out-out ActLoopNT-out 6.9438 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.38 APE8-rot-out 71.13 APE67-dihe-out -67.11, -20.05 -128.98, 52.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.238 B 366.0 332.0 15 25 14 11 [[24, 308]] 1.0 3mvm Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3NWWA Q16539 5 353 360.0 3NW:361 Type1 Inactive DFGin 5.2842 13.8833 BLBplus -115.86, 167.05 59.08, 20.31 -67.36, 154.78 45.75, 85.87 66.49, 8.6 in-in in 9.0204 Saltbr-in 2.5893 HRD-in -68.85, -58.97 77.98, -20.29 in-out-none SNCion out-none ActLoopNT-out 8.2156 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.6 APE8-rot-in 307.95 APE67-dihe-in -62.74, -26.81 -46.77, -33.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.214 0.254 A 366.0 339.0 10 25 15 10 [[24, 308]] 1.0 3nww Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3S4QA Q16539 4 352 360.0 NK0:361 Type1 Inactive DFGin 5.8843 14.169 BLBplus -109.03, 159.91 64.82, 29.39 -78.97, 147.58 44.64, 92.49 62.53, 17.35 in-in in 9.2313 Saltbr-in 2.8004 HRD-in -67.25, -52.03 73.36, -6.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.53 APE8-dihe-out -127.21, -24.07 APE8-rot-out 58.0 APE67-dihe-in -56.34, -41.67 -80.95, 5.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.5617 None None None XRAY 2.27 0.26 0.327 A 366.0 326.0 23 25 14 11 [[24, 308]] 1.0 3s4q Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KINA Q16539 5 352 360.0 1M8:401 Type1 Inactive DFGin 5.8298 14.4907 BLBplus -112.0, 159.56 58.84, 31.67 -80.2, 161.77 51.23, 91.19 70.21, 3.94 in-in in 9.3321 Saltbr-in 2.6928 HRD-in -75.58, -60.36 79.72, -18.44 in-out-out SNCioo out-out ActLoopNT-out 7.8786 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -81.36, 45.06 APE9-dihe-na -160.68, 148.72 APE8-dihe-in -80.55, 140.18 APE8-rot-out 52.55 APE67-dihe-out -62.92, -22.56 -122.89, 54.77 APE12-dist-none 999.0 APE11-dist-out 19.6485 APE10-dist-out 19.6951 APE9-dist-out 12.8871 None None None XRAY 1.97 0.186 0.217 A 366.0 338.0 10 25 17 8 [[24, 308]] 1.0 4kin Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KINB Q16539 4 352 360.0 1M8:401 Type1 Inactive DFGin 5.8331 14.3759 BLBplus -111.81, 160.82 58.79, 31.15 -82.0, 162.48 50.94, 86.22 67.7, 5.09 in-in in 9.2716 Saltbr-in 2.7051 HRD-in -77.44, -59.82 78.53, -17.64 in-out-out SNCioo out-out ActLoopNT-out 8.1687 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -117.05, 92.32 APE9-dihe-na -152.42, 131.25 APE8-dihe-in -58.54, 143.39 APE8-rot-out 65.06 APE67-dihe-in -56.63, -20.78 -125.76, 48.86 APE12-dist-none 999.0 APE11-dist-out 19.6528 APE10-dist-out 21.2323 APE9-dist-out 13.1311 None None None XRAY 1.97 0.186 0.217 B 366.0 341.0 8 25 17 8 [[24, 308]] 1.0 4kin Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KINC Q16539 4 352 360.0 1M8:401 Type1 Inactive DFGin 5.8223 14.3313 BLBplus -112.14, 159.92 56.39, 32.68 -82.61, 164.95 50.22, 87.86 66.13, 5.77 in-in in 9.2196 Saltbr-in 2.6995 HRD-in -77.09, -60.2 79.61, -18.38 in-out-out SNCioo out-out ActLoopNT-out 8.1313 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.85 APE8-dihe-in -67.36, 151.26 APE8-rot-out 182.89 APE67-dihe-in -64.44, -23.22 -157.89, 24.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7995 None None None XRAY 1.97 0.186 0.217 C 366.0 338.0 11 25 16 9 [[24, 308]] 1.0 4kin Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIND Q16539 4 354 360.0 1M8:401 Type1 Inactive DFGin 5.8375 13.9246 BLBplus -113.2, 160.86 57.37, 29.91 -79.52, 159.49 50.89, 87.6 72.34, 0.42 in-in in 8.8613 Saltbr-in 2.7368 HRD-in -76.52, -60.3 80.07, -18.04 in-out-out SNCioo out-out ActLoopNT-out 8.1205 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 62.74 APE8-dihe-in -59.81, 147.68 APE8-rot-out 180.07 APE67-dihe-in -62.05, -22.47 -108.39, 8.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4245 None None None XRAY 1.97 0.186 0.217 D 366.0 339.0 12 25 16 9 [[24, 308]] 1.0 4kin Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIPA Q16539 5 352 360.0 1R9:401 Type1 Inactive DFGin 5.7084 14.0793 BLBplus -114.41, 163.55 55.79, 23.53 -69.06, 154.65 55.02, 86.64 54.99, 29.98 in-in in 9.0858 Saltbr-in 2.823 HRD-in -67.01, -55.42 76.27, -22.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 11.59 APE8-dihe-out -146.39, -50.33 APE8-rot-in 311.75 APE67-dihe-in -68.64, -8.71 -84.46, 20.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0937 None None None XRAY 2.27 0.255 0.286 A 366.0 337.0 11 25 14 11 [[24, 308]] 1.0 4kip Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIPB Q16539 5 352 360.0 1R9:401 Type1 Inactive DFGin 5.7167 14.1161 BLBplus -114.1, 163.8 56.21, 23.48 -69.68, 154.48 55.05, 86.85 56.34, 29.94 in-in in 9.096 Saltbr-in 2.8383 HRD-in -67.08, -55.59 76.29, -22.57 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 132.1 APE9-dihe-na -60.21, -31.7 APE8-dihe-out -86.79, -6.39 APE8-rot-out 45.77 APE67-dihe-in -67.99, -26.43 -108.37, 17.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.8599 APE9-dist-out 13.386 None None None XRAY 2.27 0.255 0.286 B 366.0 338.0 10 25 15 10 [[24, 308]] 1.0 4kip Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIQA Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.9141 14.158 BLBplus -118.42, 161.56 57.68, 30.65 -79.17, 161.61 47.63, 93.06 67.87, 7.88 in-in in 9.1021 Saltbr-in 2.7625 HRD-in -78.21, -56.73 75.15, -8.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -177.16 APE8-dihe-in -53.19, 141.15 APE8-rot-none 999.0 APE67-dihe-in -58.65, -22.95 -105.79, 0.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0034 None None None XRAY 2.5 0.186 0.228 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIQB Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.8426 14.3685 BLBplus -116.24, 159.69 59.04, 30.62 -78.88, 159.93 47.84, 94.08 67.34, 8.96 in-in in 9.2385 Saltbr-in 2.7593 HRD-in -79.0, -55.49 80.13, -20.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.88 APE8-dihe-in -44.28, 116.69 APE8-rot-none 999.0 APE67-dihe-out -64.05, -20.17 -121.62, 60.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6678 None None None XRAY 2.5 0.186 0.228 B 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIQC Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.9161 14.363 BLBplus -118.73, 158.67 59.65, 31.16 -79.36, 160.3 48.33, 82.72 66.37, 9.63 in-in in 9.2238 Saltbr-in 2.7828 HRD-in -79.74, -56.13 77.72, -18.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.44 APE8-dihe-in -69.87, 141.68 APE8-rot-none 999.0 APE67-dihe-in -60.47, -18.91 -131.63, 43.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3285 None None None XRAY 2.5 0.186 0.228 C 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4KIQD Q16539 4 352 360.0 1RA:401 Type1 Inactive DFGin 5.9014 14.2596 BLBplus -118.2, 159.83 57.68, 31.41 -79.47, 160.77 46.83, 92.7 66.38, 10.78 in-in in 9.1675 Saltbr-in 2.7212 HRD-in -78.42, -57.5 78.74, -19.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -179.73 APE8-dihe-in -130.42, 158.74 APE8-rot-none 999.0 APE67-dihe-out -79.12, -17.03 -134.99, 147.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.1114 None None None XRAY 2.5 0.186 0.228 D 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 4kiq Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FKLA Q16539 4 352 360.0 FKL:361 Type1 Inactive DFGin 5.6671 14.2402 BLBplus -114.22, 158.36 70.3, 22.27 -77.13, 155.27 49.6, 86.33 76.39, 7.75 in-in in 9.0943 Saltbr-in 2.5361 HRD-in -68.8, -61.26 80.02, -18.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.3, 137.72 APE9-dihe-na -61.94, -7.95 APE8-dihe-out -75.24, -17.17 APE8-rot-out 63.55 APE67-dihe-in -64.84, -19.66 -117.76, -15.17 APE12-dist-out 22.4401 APE11-dist-out 24.5382 APE10-dist-out 18.8966 APE9-dist-out 12.0382 None None None XRAY 2.0 0.221 0.254 A 372.0 344.0 5 25 20 5 [[24, 308]] 1.0 3fkl Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FKNA Q16539 4 352 360.0 FKN:361 Type1 Inactive DFGin 4.7904 13.1791 BLBplus -103.92, 161.19 68.94, 15.34 -60.02, 144.92 37.34, 90.85 95.68, 999.0 in-in in 9.1446 Saltbr-in 2.8037 HRD-in -68.47, -52.64 81.71, -16.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.64, 134.39 APE9-dihe-na -62.8, -16.56 APE8-dihe-out -67.68, -16.81 APE8-rot-out 53.51 APE67-dihe-in -61.37, -24.12 -116.82, -19.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0157 None None None XRAY 2.0 0.215 0.242 A 372.0 346.0 3 25 22 3 [[24, 308]] 1.0 3fkn Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FL4A Q16539 4 352 360.0 FL4:361 Type1 Inactive DFGin 4.8043 13.479 BLBplus -111.14, 160.38 67.95, 24.65 -67.44, 145.81 38.5, 85.33 70.07, 999.0 in-in in 9.1978 Saltbr-in 2.8087 HRD-in -65.46, -57.78 85.76, -17.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -132.91, 132.36 APE9-dihe-na -59.93, -23.61 APE8-dihe-out -59.15, -20.92 APE8-rot-out 61.36 APE67-dihe-in -62.92, -20.8 -113.88, -17.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2204 None None None XRAY 1.8 0.218 0.243 A 372.0 339.0 10 25 21 4 [[24, 308]] 1.0 3fl4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FLSA Q16539 4 352 360.0 FLS:361 Type1 Inactive DFGin 4.6684 13.8126 BLBplus -113.35, 162.5 69.6, 18.68 -67.04, 145.99 47.14, 89.36 71.76, 9.42 in-in in 9.0455 Saltbr-in 2.4805 HRD-in -66.61, -45.2 72.22, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.1, 133.44 APE9-dihe-na -60.87, -7.92 APE8-dihe-out -75.41, -18.86 APE8-rot-out 57.36 APE67-dihe-in -58.7, -26.83 -117.81, -17.11 APE12-dist-out 22.1926 APE11-dist-out 24.1021 APE10-dist-out 18.4502 APE9-dist-out 12.39 None None None XRAY 2.3 0.25 0.294 A 372.0 343.0 6 25 23 2 [[24, 308]] 1.0 3fls Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FLWA Q16539 4 352 360.0 FLW:361 Type1 Inactive DFGin 4.9914 14.2902 BLBplus -111.65, 161.12 63.95, 35.17 -86.23, 155.47 50.75, 86.69 80.75, 999.0 in-in in 9.1134 Saltbr-in 2.5483 HRD-in -66.96, -51.63 76.82, -13.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.69, 136.03 APE9-dihe-na -60.46, -18.68 APE8-dihe-out -65.02, -23.67 APE8-rot-out 50.34 APE67-dihe-in -62.62, -24.23 -110.6, -16.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9335 None None None XRAY 2.1 0.213 0.237 A 372.0 345.0 3 25 22 3 [[24, 308]] 1.0 3flw Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FLYA Q16539 4 352 360.0 FLY:361 Type1 Inactive DFGin 4.9041 14.2356 BLBplus -110.95, 154.46 66.68, 35.35 -80.29, 147.81 44.1, 87.62 72.1, 16.43 in-in in 9.1852 Saltbr-in 2.4661 HRD-in -67.73, -54.84 84.66, -16.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.85, 135.56 APE9-dihe-na -62.9, -18.3 APE8-dihe-out -63.51, -18.52 APE8-rot-out 55.5 APE67-dihe-in -61.31, -21.95 -117.65, -19.04 APE12-dist-out 21.9761 APE11-dist-out 24.0595 APE10-dist-out 18.3714 APE9-dist-out 11.9189 None None None XRAY 1.8 0.22 0.245 A 372.0 347.0 2 25 23 2 [[24, 308]] 1.0 3fly Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FLZA Q16539 4 352 360.0 FLZ:361 Type1 Inactive DFGin 5.0224 14.5597 BLBplus -112.56, 159.04 69.03, 31.91 -85.37, 150.96 47.3, 88.83 71.95, 20.33 in-in in 9.3011 Saltbr-in 2.675 HRD-in -67.62, -51.08 81.59, -16.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.57, 136.86 APE9-dihe-na -59.65, -16.05 APE8-dihe-out -70.93, -17.35 APE8-rot-out 54.38 APE67-dihe-in -62.29, -21.11 -113.79, -19.95 APE12-dist-out 22.0928 APE11-dist-out 24.1903 APE10-dist-out 18.512 APE9-dist-out 12.1512 None None None XRAY 2.23 0.214 0.251 A 372.0 347.0 2 25 23 2 [[24, 308]] 1.0 3flz Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FMHA Q16539 4 352 360.0 533:361 Type1 Inactive DFGin 4.8698 13.955 BLBplus -105.43, 156.22 65.66, 28.54 -72.9, 146.69 42.62, 89.43 73.67, 16.55 in-in in 9.2456 Saltbr-in 2.5881 HRD-in -66.12, -54.34 83.29, -19.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.51, 136.05 APE9-dihe-na -60.18, -18.37 APE8-dihe-out -63.92, -21.68 APE8-rot-out 63.81 APE67-dihe-in -64.6, -20.22 -113.62, -15.72 APE12-dist-out 21.982 APE11-dist-out 24.0881 APE10-dist-out 18.4408 APE9-dist-out 12.1626 None None None XRAY 1.9 0.218 0.246 A 372.0 347.0 2 25 23 2 [[24, 308]] 1.0 3fmh Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FMKA Q16539 4 352 360.0 FMK:361 Type1 Inactive DFGin 4.9247 13.7994 BLBplus -112.17, 148.9 62.85, 38.56 -78.11, 150.42 42.19, 85.47 69.39, 15.49 in-in in 9.1489 Saltbr-in 2.6332 HRD-in -67.87, -55.08 82.14, -17.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.81, 134.32 APE9-dihe-na -62.69, -17.2 APE8-dihe-out -65.89, -17.03 APE8-rot-out 56.12 APE67-dihe-in -61.48, -22.33 -117.35, -20.7 APE12-dist-out 22.1271 APE11-dist-out 24.1209 APE10-dist-out 18.4211 APE9-dist-out 11.9605 None None None XRAY 1.7 0.204 0.224 A 372.0 346.0 3 25 22 3 [[24, 308]] 1.0 3fmk Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FMMA Q16539 4 352 360.0 XI2:361 Type1 Inactive DFGin 4.7682 13.4507 BLBplus -98.73, 158.86 67.25, 21.18 -69.18, 146.01 43.41, 87.89 71.96, 10.19 in-in in 9.2237 Saltbr-in 2.6641 HRD-in -65.66, -56.28 86.92, -21.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.47, 134.19 APE9-dihe-na -60.38, -14.86 APE8-dihe-out -69.41, -16.91 APE8-rot-out 61.13 APE67-dihe-in -65.56, -21.54 -116.99, -14.56 APE12-dist-out 22.2545 APE11-dist-out 24.3333 APE10-dist-out 18.646 APE9-dist-out 12.268 None None None XRAY 2.0 0.214 0.242 A 372.0 346.0 3 25 22 3 [[24, 308]] 1.0 3fmm Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FMNA Q16539 4 352 360.0 530:361 Type1 Inactive DFGin 4.8329 13.4655 BLBplus -104.04, 155.55 66.08, 26.65 -71.48, 145.7 42.74, 89.21 83.26, 999.0 in-in in 9.0751 Saltbr-in 2.7869 HRD-in -67.59, -53.8 83.21, -19.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -133.88, 134.88 APE9-dihe-na -63.74, -14.43 APE8-dihe-out -64.98, -21.19 APE8-rot-out 59.83 APE67-dihe-in -62.49, -23.26 -114.32, -17.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.095 None None None XRAY 1.9 0.206 0.242 A 372.0 341.0 8 25 21 4 [[24, 308]] 1.0 3fmn Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3E92A Q16539 3 352 360.0 G6A:361 Type1 Inactive DFGin 5.54 13.9383 BLBplus -118.48, 163.03 66.45, 15.69 -63.59, 154.46 39.99, 80.08 65.45, 13.13 in-in in 8.6059 Saltbr-in 2.593 HRD-in -66.1, -56.76 76.48, -15.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.92, 133.57 APE9-dihe-na -59.41, -20.48 APE8-dihe-out -64.59, -18.95 APE8-rot-out 58.81 APE67-dihe-in -65.96, -18.46 -116.06, -15.19 APE12-dist-out 22.2163 APE11-dist-out 24.2329 APE10-dist-out 18.5555 APE9-dist-out 11.8632 None None CSO162 XRAY 2.0 0.174 0.216 A 371.0 349.0 1 25 24 1 [[24, 308]] 1.0 3e92 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.5e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MPTA Q16539 4 352 360.0 1GK:361 Type1 Inactive DFGin 5.038 13.9306 BLBplus -127.08, 159.45 63.85, 35.02 -73.68, 152.66 31.46, 78.25 53.08, 37.18 in-in in 9.1792 Saltbr-in 2.6372 HRD-in -74.41, -57.49 77.98, -16.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.14, 130.25 APE9-dihe-na -58.41, -25.43 APE8-dihe-out -57.22, -18.71 APE8-rot-out 61.81 APE67-dihe-in -64.25, -20.9 -117.57, -13.29 APE12-dist-out 21.5931 APE11-dist-out 23.6672 APE10-dist-out 17.9131 APE9-dist-out 11.5686 None None None XRAY 1.89 0.239 0.298 A 371.0 347.0 2 25 23 2 [[24, 308]] 1.0 3mpt Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.5e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3DT1A Q16539 1 352 360.0 P40:60361 Type1 Inactive DFGin 5.2661 13.9573 BLBplus -113.29, 169.9 39.88, 60.05 -100.91, 153.78 42.94, 70.44 60.38, 18.47 in-in in 8.9251 Saltbr-in 3.0344 HRD-in -74.95, -48.4 72.93, -13.41 in-out-out SNCioo out-out ActLoopNT-out 9.5746 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -124.97, 138.41 APE9-dihe-na -69.69, -13.12 APE8-dihe-out -63.44, -40.84 APE8-rot-out 61.54 APE67-dihe-in -94.37, -9.12 -96.58, 18.94 APE12-dist-out 22.079 APE11-dist-out 24.1624 APE10-dist-out 18.4006 APE9-dist-out 12.5547 None None None XRAY 2.8 0.214 0.28 A 383.0 352.0 0 25 25 0 [[24, 308]] 1.0 3dt1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4F9YA Q16539 5 353 360.0 LM3:403 Type1 Inactive DFGin 4.882 13.9136 BLBplus -102.45, 160.65 29.81, 64.99 -90.71, 149.15 35.58, 96.77 57.65, 21.07 in-in in 9.6237 Saltbr-in 3.0539 HRD-in -68.22, -54.55 80.29, -15.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 105.56 APE9-dihe-na -74.97, 136.74 APE8-dihe-out -59.26, -38.38 APE8-rot-in 286.11 APE67-dihe-in -60.96, -24.6 -57.6, -25.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.4839 APE9-dist-out 11.632 None None CME119,CME162 XRAY 1.85 0.169 0.2 A 383.0 339.0 10 25 15 10 [[24, 308]] 1.0 4f9y Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HL7A Q16539 6 352 360.0 I47:60401,I46:60402 Type1,Allosteric Inactive DFGin 5.2347 13.6446 BLBplus -124.2, 170.0 68.57, 19.0 -68.49, 146.41 46.64, 88.83 77.19, -0.15 in-in in 9.0409 Saltbr-in 2.4506 HRD-in -63.1, -58.98 80.27, -17.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.78 APE8-dihe-out -66.44, -27.56 APE8-rot-none 999.0 APE67-dihe-in -57.86, -27.57 -47.26, -39.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5313 None None None XRAY 1.88 0.2 0.228 A 360.0 336.0 11 25 14 11 [[24, 308]] 1.0 3hl7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ROCA Q16539 5 352 360.0 29A:401,29B:402 Type1,Allosteric Inactive DFGin 4.9964 13.6824 BLBplus -116.4, 161.83 65.66, 26.8 -75.68, 149.71 49.46, 88.61 59.74, 17.57 in-out in 9.1566 Saltbr-out 3.8177 HRD-in -68.7, -52.88 78.63, -20.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 77.39 APE9-dihe-na -67.53, 134.61 APE8-dihe-out -65.0, -31.29 APE8-rot-none 999.0 APE67-dihe-in -56.87, -28.57 -61.2, -29.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.6616 APE9-dist-out 11.8193 None None None XRAY 1.7 0.348 0.276 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3roc Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HLLA Q16539 5 352 360.0 I45:60401,I46:60402,PO2:60501 Type1,Allosteric,Allosteric Inactive DFGin 5.053 13.5716 BLBplus -104.99, 158.54 67.03, 24.11 -71.37, 152.95 45.58, 87.31 67.6, 1.84 in-out in 9.1864 Saltbr-out 3.9688 HRD-in -64.7, -58.11 82.94, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -18.34 APE9-dihe-na -77.72, 94.48 APE8-dihe-out -49.19, -31.53 APE8-rot-none 999.0 APE67-dihe-in -66.1, -25.14 -64.45, -21.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.8147 APE9-dist-out 11.6667 None None None XRAY 1.95 0.219 0.254 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3hll Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2I0HA Q16539 4 352 360.0 222:400,222:3400 Type1,Type1 Inactive DFGin 4.6526 13.7145 BLBplus -106.37, 160.45 62.42, 22.28 -65.18, 141.95 38.84, 88.65 71.92, -3.35 in-in in 9.2912 Saltbr-in 2.6046 HRD-in -66.5, -53.14 79.92, -16.34 in-out-out SNCioo out-out ActLoopNT-out 10.2101 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -130.31, 137.86 APE9-dihe-na -63.58, -15.33 APE8-dihe-out -67.32, -21.26 APE8-rot-out 51.33 APE67-dihe-in -56.99, -26.01 -113.04, -22.46 APE12-dist-out 21.571 APE11-dist-out 23.4025 APE10-dist-out 17.6568 APE9-dist-out 11.7358 C162S None None XRAY 2.0 0.18 0.228 A 366.0 349.0 0 25 25 0 [[24, 308]] 1.0 2i0h Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.6e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2RG5A Q16539 4 351 360.0 279:501 Type1.5_Back Inactive DFGin 5.3583 14.3061 BLBplus -115.64, 149.29 66.69, 28.57 -75.01, 151.54 46.26, 92.22 68.04, 7.04 in-in in 9.3341 Saltbr-in 2.9051 HRD-in -70.53, -62.91 89.6, -20.1 in-out-out SNCioo out-out ActLoopNT-out 6.4192 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 50.44 APE8-rot-out 58.38 APE67-dihe-in -62.43, -9.83 -150.6, -16.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.24 0.305 A 366.0 333.0 15 25 14 11 [[24, 308]] 1.0 2rg5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3BX5A Q16539 5 352 360.0 304:501 Type1.5_Back Inactive DFGin 4.9015 13.3702 BLBplus -125.09, 165.17 58.72, 24.42 -71.11, 153.49 43.25, 78.29 58.15, 20.72 in-in in 8.9579 Saltbr-in 2.6694 HRD-in -67.15, -55.19 83.68, -26.42 in-out-none SNCion out-none ActLoopNT-out 8.2522 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.07 APE8-rot-in 330.74 APE67-dihe-in -57.19, -30.02 -67.98, -18.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.229 0.32 A 366.0 338.0 10 25 15 10 [[24, 308]] 1.0 3bx5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3L8XA Q16539 4 352 360.0 N4D:361 Type1.5_Back Inactive DFGin 5.4768 13.7649 BLBplus -103.89, 151.97 54.08, 30.21 -68.52, 159.03 49.48, 84.71 59.15, 8.69 in-in in 8.9718 Saltbr-in 2.526 HRD-in -65.63, -40.87 63.88, -26.37 in-out-out SNCioo out-out ActLoopNT-out 9.0649 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -50.97 APE8-dihe-out -101.68, -30.89 APE8-rot-out 180.95 APE67-dihe-in -30.48, -35.23 -55.83, -28.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5884 None None None XRAY 2.4 0.225 0.319 A 366.0 326.0 23 25 15 10 [[24, 308]] 1.0 3l8x Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2RG6A Q16539 4 352 360.0 287:501,287:502 Type1.5_Back,Allosteric Inactive DFGin 5.1901 14.4166 BLBplus -115.84, 160.49 63.44, 25.5 -76.4, 154.46 53.74, 93.4 66.11, 10.49 in-in in 9.198 Saltbr-in 2.689 HRD-in -75.72, -61.01 84.35, -16.16 in-out-out SNCioo out-out ActLoopNT-out 7.584 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -44.76 APE8-dihe-out -57.98, -37.66 APE8-rot-out 59.87 APE67-dihe-in -66.56, -22.22 -53.28, -37.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.039 None None None XRAY 1.72 0.2 0.221 A 366.0 335.0 14 25 15 10 [[24, 308]] 1.0 2rg6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4E6AA Q16539 4 351 360.0 0O9:500 Allosteric Inactive DFGin 7.8292 16.7355 None -116.35, 173.04 63.5, -177.46 -171.04, 999.0 277.86, 82.56 999.0, 999.0 in-in in 9.4716 Saltbr-in 2.9275 HRD-in -64.73, -56.61 86.56, -18.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.14, -22.79 999.0, 21.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.224 0.273 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e6a Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4E6CA Q16539 4 351 360.0 0O8:500 Allosteric Inactive DFGin 7.12 15.5419 None -107.87, 169.94 71.07, 48.65 -62.86, 999.0 316.7, 83.95 999.0, 999.0 in-in in 9.053 Saltbr-in 3.1301 HRD-in -64.38, -54.16 91.01, -29.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.63 APE8-rot-out 211.4 APE67-dihe-in -58.37, -26.81 -122.63, 18.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.22 0.292 A 360.0 330.0 18 25 10 15 [[24, 308]] 1.0 4e6c Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5N67A Q16539 5 353 360.0 8ON:401 Allosteric Inactive DFGin 6.8653 15.6092 None -128.23, -179.23 57.11, 61.45 -58.51, 999.0 306.28, 87.84 999.0, 999.0 in-in in 9.4444 Saltbr-in 3.0167 HRD-in -67.68, -53.37 80.76, -14.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.97 APE8-dihe-out -66.09, -43.78 APE8-rot-in 291.76 APE67-dihe-in -63.81, -23.7 -63.35, -24.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7672 None None None XRAY 1.9 0.191 0.222 A 360.0 327.0 22 25 11 14 [[24, 308]] 1.0 5n67 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 8X3MA Q16539 4 353 360.0 B8Z:401 Allosteric Inactive DFGin 7.7119 16.8556 None -115.94, 168.03 71.62, -88.99 88.0, 131.81 286.06, 88.99 -70.61, 105.76 in-in in 9.6027 Saltbr-in 3.0578 HRD-in -66.17, -53.58 79.95, -8.82 in-out-out SNCioo out-out ActLoopNT-out 10.5579 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.62, 133.04 APE9-dihe-na -62.46, -10.4 APE8-dihe-out -67.81, -17.48 APE8-rot-out 51.83 APE67-dihe-in -60.97, -25.8 -116.4, -18.75 APE12-dist-out 22.0398 APE11-dist-out 24.1061 APE10-dist-out 18.4386 APE9-dist-out 11.7912 None None None XRAY 1.85 0.183 0.226 A 365.0 350.0 0 25 25 0 [[24, 308]] 1.0 8x3m Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4DLIA Q16539 5 354 360.0 IRG:401,IRG:402 Allosteric,Allosteric Inactive DFGin 9.8147 11.8562 None -104.36, 150.39 -73.0, -47.15 -137.92, 126.59 314.79, 100.08 -44.68, 999.0 in-in in 9.4387 Saltbr-in 2.8448 HRD-in -68.95, -53.08 77.7, -11.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 123.1 APE9-dihe-na -70.95, 129.15 APE8-dihe-out -52.5, -43.49 APE8-rot-in 288.97 APE67-dihe-in -64.32, -23.54 -55.51, -29.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0955 None None None XRAY 1.91 0.216 0.255 A 360.0 334.0 16 25 13 12 [[24, 308]] 1.0 4dli Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH4A Q16539 4 354 360.0 IRG:401,0OL:402 Allosteric,Type1 Inactive DFGin 10.8466 12.1969 None -91.43, 145.17 -57.64, -47.01 -148.78, 133.96 289.87, 102.95 -106.02, 178.5 in-in in 9.3455 Saltbr-in 3.5333 HRD-in -75.34, -49.4 79.8, -22.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 89.91 APE9-dihe-na -88.64, 150.01 APE8-dihe-out -60.61, -41.02 APE8-rot-in 254.43 APE67-dihe-in -62.83, -20.65 -63.82, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.1023 APE9-dist-out 11.2223 None None None XRAY 2.5 0.234 0.317 A 360.0 337.0 14 25 15 10 [[24, 308]] 1.0 4eh4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3C5UA Q16539 4 352 360.0 P41:361,P41:362 Allosteric,Type1 Inactive DFGin 5.9263 14.6107 None -79.99, -52.08 -111.86, 147.19 165.52, 164.69 70.95, 141.36 -178.3, -57.28 in-in in 9.4101 Saltbr-in 2.8949 HRD-in -58.08, -50.48 77.9, -18.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 89.15 APE9-dihe-na -79.53, 169.16 APE8-dihe-in -115.39, 178.62 APE8-rot-out 194.24 APE67-dihe-out 106.71, -27.43 -78.01, -142.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.0025 APE9-dist-out 13.5624 None None None XRAY 2.8 0.263 0.296 A 366.0 338.0 11 25 14 11 [[24, 308]] 1.0 3c5u Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4E5AX Q16539 3 353 360.0 No_ligand No_ligand Inactive DFGin 7.4271 16.6777 None -111.06, 176.17 53.13, 71.95 -70.18, 999.0 294.84, 64.48 999.0, 999.0 in-in in 9.576 Saltbr-in 3.5066 HRD-in -71.06, -54.61 88.3, -21.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 105.51 APE8-dihe-in -65.33, 145.05 APE8-rot-out 181.03 APE67-dihe-in -68.36, -17.57 -107.7, 17.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7943 W197A None None XRAY 1.87 0.219 0.253 X 360.0 332.0 19 25 11 14 [[24, 308]] 1.0 4e5a Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3OD6X Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGin 7.1693 14.5472 None -107.32, -35.37 -122.54, 110.88 -101.89, 179.03 304.51, 65.36 116.69, -52.36 in-in in 9.7055 Saltbr-in 3.5749 HRD-out -70.82, 103.82 -92.19, 25.39 in-in-out SNCiio in-out ActLoopNT-in 2.9041 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -86.05, 124.21 APE9-dihe-na 179.03, 165.34 APE8-dihe-in -50.68, 120.55 APE8-rot-in 316.14 APE67-dihe-in -54.18, -37.51 -81.72, -17.02 APE12-dist-in 10.2458 APE11-dist-out 6.7415 APE10-dist-out 9.7315 APE9-dist-out 7.1949 Y323T None None XRAY 2.682 0.215 0.283 X 360.0 344.0 5 25 25 0 [[24, 308]] 1.0 3od6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3OEFX Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 4.9023 12.1341 None -108.05, 167.45 -157.07, -159.47 61.31, 35.4 325.61, 112.03 64.1, 24.95 in-in in 8.824 Saltbr-in 2.7137 HRD-in -68.42, -53.79 78.26, -14.32 in-out-none SNCion out-none ActLoopNT-out 17.9811 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.36 APE8-rot-in 260.2 APE67-dihe-in -60.02, -22.95 -112.04, 6.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y323F None None XRAY 1.6 0.187 0.221 X 360.0 334.0 14 25 14 11 [[24, 308]] 1.0 3oef Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ODYX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.2927 14.9518 None -99.56, -49.69 -113.79, 73.73 -150.67, 152.99 55.1, 98.03 53.69, 11.06 out-out out 11.8635 Saltbr-out 8.8242 HRD-out -75.99, 166.59 -145.03, -3.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 113.54 APE9-dihe-na -84.24, -15.35 APE8-dihe-out -79.73, -37.47 APE8-rot-in 312.81 APE67-dihe-in -57.52, -26.46 -53.29, -32.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9259 APE9-dist-out 11.0075 Y323Q None None XRAY 2.2 0.238 0.304 X 360.0 321.0 29 25 15 10 [[24, 308]] 1.0 3ody Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MGYA Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8489 15.4078 None -96.6, 163.16 144.18, -87.53 -41.62, 999.0 25.94, 59.9 999.0, 999.0 in-in in 9.8726 Saltbr-in 2.9683 HRD-in -64.11, -58.21 85.85, 0.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 165.22 APE8-rot-out 214.38 APE67-dihe-in -69.5, -24.6 -110.92, 8.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.243 0.291 A 360.0 329.0 19 25 10 15 [[24, 308]] 1.0 3mgy Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4E5BA Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGin 7.7496 16.4477 None -109.02, 158.46 31.08, 83.24 -71.5, 999.0 299.95, 31.84 999.0, 999.0 in-in in 9.2652 Saltbr-in 2.8145 HRD-in -56.8, -65.03 90.55, -13.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.6, -23.21 999.0, 23.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.237 0.279 A 360.0 324.0 23 25 9 16 [[24, 308]] 1.0 4e5b Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ODZX Q16539 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.0644 15.3431 None -127.95, -15.93 -113.67, 56.52 -144.01, 156.75 54.25, 120.62 60.75, 23.2 out-out out 11.618 Saltbr-out 9.0277 HRD-out -65.57, 130.15 -105.04, 19.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.07 APE9-dihe-na -94.07, 5.61 APE8-dihe-in -177.03, 113.52 APE8-rot-out 172.92 APE67-dihe-in -61.07, -28.1 -95.52, 3.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.3127 APE9-dist-out 12.5093 Y323R None None XRAY 2.3 0.223 0.282 X 360.0 335.0 15 25 15 10 [[24, 308]] 1.0 3odz Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5ETCA Q16539 1 352 360.0 No_ligand No_ligand Inactive DFGin 7.9268 17.5065 None -109.69, 177.11 57.89, 82.77 -103.25, -87.08 272.53, 90.11 -31.01, -89.71 in-out in 9.7017 Saltbr-out 3.6009 HRD-in -68.38, -45.82 79.56, -12.49 out-out-out SNCooo out-out ActLoopNT-out 10.994 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -140.41, 139.5 APE9-dihe-na -66.28, -17.2 APE8-dihe-out -69.09, -9.59 APE8-rot-out 56.2 APE67-dihe-in -64.25, -22.37 -125.41, -16.44 APE12-dist-out 21.1759 APE11-dist-out 23.1029 APE10-dist-out 17.3278 APE9-dist-out 11.8982 None None None XRAY 2.422 0.197 0.242 A 363.0 352.0 0 25 25 0 [[24, 308]] 1.0 5etc Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WFCA Q16539 5 351 360.0 No_ligand No_ligand Inactive DFGin 7.6408 16.6525 None -118.35, 179.66 63.95, -92.6 123.2, 999.0 266.78, 80.69 999.0, 999.0 in-out in 9.5424 Saltbr-out 3.6831 HRD-in -80.8, -27.0 48.37, 14.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -129.45, 133.38 APE9-dihe-na -57.59, -22.46 APE8-dihe-out -57.94, -20.68 APE8-rot-out 53.19 APE67-dihe-in -65.99, -19.65 -113.55, -17.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7898 None None None XRAY 2.3 0.213 0.297 A 366.0 340.0 5 25 20 5 [[24, 308]] 1.0 1wfc Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MH0A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGin 8.4153 16.8838 None -94.37, 151.84 67.81, 17.94 -52.66, 126.59 999.0, 999.0 86.82, 1.89 in-in in 9.3128 Saltbr-in 2.9134 HRD-in -65.91, -50.91 79.65, -20.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.01 APE8-rot-out 35.18 APE67-dihe-in -59.42, -23.13 -101.48, 7.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169A None None XRAY 2.0 0.232 0.28 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3mh0 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3IW6A Q16539 4 353 360.0 PP0:361 Type1 Inactive DFGin 10.6593 12.8022 None -107.45, 146.07 -62.15, -52.96 -135.84, 140.51 306.3, 96.66 -100.47, -175.96 in-in in 8.9094 Saltbr-in 2.7027 HRD-in -68.9, -58.44 84.06, -12.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 89.13 APE9-dihe-na -68.25, 143.74 APE8-dihe-out -81.14, -28.36 APE8-rot-out 119.31 APE67-dihe-in -61.88, -28.19 -54.39, -28.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.738 APE9-dist-out 12.6069 C119S,C162S,A172C,F327L None None XRAY 2.1 0.213 0.273 A 360.0 337.0 13 25 14 11 [[24, 308]] 1.0 3iw6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3IW7A Q16539 4 352 360.0 IPK:361 Type1 Inactive DFGin 10.7835 12.9675 None -101.08, 142.65 -64.35, -57.15 -132.52, 130.32 305.61, 101.42 -90.75, 171.73 in-in in 9.027 Saltbr-in 3.0854 HRD-in -64.07, -57.02 86.6, -16.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.97 APE8-dihe-out -80.2, 2.17 APE8-rot-out 181.73 APE67-dihe-in -62.05, -22.02 -116.3, -9.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0592 C119S,C162S,A172C,F327L None None XRAY 2.4 0.203 0.282 A 360.0 335.0 14 25 13 12 [[24, 308]] 1.0 3iw7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2BAQA Q16539 5 351 360.0 PQB:401 Type1 Inactive DFGin 10.3272 11.741 None -89.31, 142.2 -51.16, -47.94 -140.37, 153.62 295.29, 101.84 -84.84, -141.61 in-in in 8.4503 Saltbr-in 2.9936 HRD-in -54.23, -50.45 81.43, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -91.51, 119.1 APE9-dihe-na -74.33, 131.38 APE8-dihe-out -51.32, -39.83 APE8-rot-in 282.97 APE67-dihe-in -50.36, -10.98 -69.35, -26.54 APE12-dist-none 999.0 APE11-dist-in 10.1777 APE10-dist-out 10.48 APE9-dist-out 11.6645 V30I None CSS162 XRAY 2.8 0.222 0.296 A 365.0 330.0 17 25 16 9 [[24, 308]] 1.0 2baq Homo sapiens CMGC_MAPK14_HUMAN CMGC 4e-85 291.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WBOA Q16539 4 354 360.0 2CH:1355 Type1 Inactive DFGin 7.5035 16.9555 None -102.06, -162.61 -36.66, 129.23 -76.33, 147.94 286.93, 61.58 -66.99, 104.73 in-in in 9.724 Saltbr-in 2.7727 HRD-in -73.99, -52.37 82.98, -14.31 in-out-out SNCioo out-out ActLoopNT-out 10.5915 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.64, 132.01 APE9-dihe-na -58.44, -25.39 APE8-dihe-out -53.56, -33.51 APE8-rot-out 45.91 APE67-dihe-in -69.56, -19.55 -106.13, -10.44 APE12-dist-out 21.7087 APE11-dist-out 23.849 APE10-dist-out 18.1619 APE9-dist-out 11.712 None None None XRAY 2.16 0.167 0.22 A 360.0 351.0 0 25 25 0 [[24, 308]] 1.0 1wbo Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5OMGA Q16539 4 353 360.0 9Y8:402 Type1 Inactive DFGin 10.9259 12.75 None -99.59, 155.64 -73.45, -50.39 -143.59, 137.7 303.2, 98.46 -92.47, -157.32 in-in in 9.0658 Saltbr-in 3.1972 HRD-in -65.81, -53.84 75.16, -16.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 84.11 APE9-dihe-na -56.7, 137.85 APE8-dihe-out -66.22, -35.89 APE8-rot-out 184.11 APE67-dihe-in -59.63, -25.96 -58.79, -27.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.0608 APE9-dist-out 11.9487 None None None XRAY 2.0 0.186 0.245 A 360.0 337.0 13 25 15 10 [[24, 308]] 1.0 5omg Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9YTYA Q16539 4 353 360.0 A1BB6:402 Type1 Inactive DFGin 4.6111 13.1622 None -120.16, 162.46 56.72, 51.46 -84.98, 999.0 26.65, 85.72 999.0, 999.0 in-in in 9.4594 Saltbr-in 2.8615 HRD-in -70.78, -49.19 75.68, -17.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.8 APE8-dihe-out -66.34, -34.75 APE8-rot-in 298.99 APE67-dihe-in -64.81, -21.23 -60.57, -20.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7554 None None None XRAY 2.25 0.211 0.254 A 360.0 336.0 14 25 11 14 [[24, 308]] 1.0 9yty Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.8012 12.5528 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.5549 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.8014 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.7622 APE9-dist-out 12.6517 None None None XRAY 2.0 0.234 0.278 A 360.0 345.0 6 25 19 6 [[24, 308]] 1.0 3qud Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.6415 12.3386 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.9604 Saltbr-in 2.6567 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.2792 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1952 APE9-dist-out 11.3927 None None None XRAY 2.7 0.23 0.311 A 360.0 343.0 6 25 19 6 [[24, 308]] 1.0 3que Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ZSIA Q16539 6 352 360.0 52P:1000 Type1 Inactive DFGin 10.4689 12.2756 None -99.24, 157.46 -83.12, -44.9 -141.74, 118.5 319.2, 96.5 -93.21, -169.85 in-in in 8.8878 Saltbr-in 3.0614 HRD-in -68.1, -49.59 77.07, -12.99 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.82 APE8-rot-in 291.48 APE67-dihe-in -55.25, -30.12 -56.65, -32.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.234 0.271 A 362.0 326.0 21 25 12 13 [[24, 308]] 1.0 3zsi Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9MHBA Q16539 4 353 360.0 A1BLA:401 Type1 Inactive DFGin 7.102 16.2712 None -117.98, 165.25 51.74, 50.71 -38.59, 999.0 301.84, 11.59 999.0, 999.0 in-in in 9.4983 Saltbr-in 2.8857 HRD-in -70.02, -56.7 79.98, -12.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -51.26 APE9-dihe-na -76.26, 128.02 APE8-dihe-out -60.23, -38.8 APE8-rot-in 294.53 APE67-dihe-in -63.02, -23.59 -57.69, -25.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5631 None None CME162 XRAY 1.65 0.174 0.202 A 362.0 337.0 13 25 12 13 [[24, 308]] 1.0 9mhb Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FC1X Q16539 5 353 360.0 52P:362 Type1 Inactive DFGin 7.1239 15.1868 None -126.14, -173.97 53.21, -144.46 158.6, 119.78 279.97, 109.61 999.0, 999.0 in-in in 9.0296 Saltbr-in 2.6197 HRD-in -59.7, -53.23 81.3, -16.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -128.32, 135.87 APE9-dihe-na -60.12, -21.5 APE8-dihe-out -62.23, -25.4 APE8-rot-out 50.45 APE67-dihe-in -63.14, -19.02 -109.22, -16.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2558 None None None XRAY 2.4 0.204 0.251 X 366.0 334.0 13 25 17 8 [[24, 308]] 1.0 3fc1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3BV2A Q16539 5 351 360.0 P38:501 Type1 Inactive DFGin 10.9192 11.9511 None -130.49, -172.23 -144.15, 148.34 64.11, 33.68 315.43, 116.87 -55.63, 125.6 in-in in 9.1734 Saltbr-in 2.72 HRD-in -59.8, -67.17 84.25, -8.03 in-out-out SNCioo out-out ActLoopNT-out 21.9505 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.36 APE8-dihe-out -57.65, -17.83 APE8-rot-out 225.25 APE67-dihe-in -64.72, -27.84 -71.88, -20.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1463 None None None XRAY 2.4 0.209 0.263 A 366.0 337.0 10 25 15 10 [[24, 308]] 1.0 3bv2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3OCGA Q16539 4 352 360.0 OCG:361 Type1 Inactive DFGin 5.2198 14.3908 None -93.64, -75.59 -102.1, 63.24 -58.64, -80.69 42.2, 96.84 -84.43, 26.24 in-in in 9.0686 Saltbr-in 2.6197 HRD-in -63.56, -51.33 77.03, -20.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 103.73 APE8-rot-out 176.87 APE67-dihe-in -64.6, -19.08 -164.89, -32.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.214 0.27 A 366.0 336.0 13 25 12 13 [[24, 308]] 1.0 3ocg Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2GFSA Q16539 5 352 360.0 PQB:361 Type1 Inactive DFGin 7.4894 16.1685 None -132.16, -175.45 50.97, 60.34 -61.94, 999.0 284.15, 70.88 999.0, 999.0 in-in in 9.1388 Saltbr-in 2.7264 HRD-in -67.49, -53.73 80.94, -11.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.15, 132.57 APE9-dihe-na -61.35, -21.8 APE8-dihe-out -55.56, -23.97 APE8-rot-out 51.68 APE67-dihe-in -64.89, -19.57 -114.73, -17.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0158 None None None XRAY 1.752 0.206 0.239 A 372.0 344.0 4 25 21 4 [[24, 308]] 1.0 2gfs Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FMLA Q16539 4 352 360.0 FML:361 Type1 Inactive DFGin 7.3213 16.1677 None -113.5, 169.93 78.68, -95.68 95.06, 999.0 286.66, 90.12 999.0, 999.0 in-in in 9.4074 Saltbr-in 2.6446 HRD-in -67.48, -49.5 80.29, -18.01 in-out-out SNCioo out-out ActLoopNT-out 10.2813 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.68, 134.28 APE9-dihe-na -62.37, -13.16 APE8-dihe-out -68.44, -18.97 APE8-rot-out 59.25 APE67-dihe-in -63.75, -24.61 -116.53, -16.96 APE12-dist-out 21.7069 APE11-dist-out 23.7308 APE10-dist-out 17.9821 APE9-dist-out 11.9013 None None None XRAY 2.1 0.216 0.245 A 372.0 342.0 7 25 24 1 [[24, 308]] 1.0 3fml Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3FSKA Q16539 5 352 360.0 RO6:450 Type1 Inactive DFGin 7.5793 16.3094 None -136.71, -175.6 44.08, 65.21 -58.68, 999.0 291.46, 58.68 999.0, 999.0 in-in in 9.2711 Saltbr-in 2.5853 HRD-in -71.16, -52.26 76.45, -12.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -137.29, 134.45 APE9-dihe-na -62.73, -15.05 APE8-dihe-out -64.93, -17.06 APE8-rot-out 49.49 APE67-dihe-in -61.37, -23.14 -117.2, -17.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9695 None None None XRAY 2.0 0.207 0.243 A 372.0 342.0 6 25 19 6 [[24, 308]] 1.0 3fsk Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.6e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HA8A Q16539 4 352 360.0 5JZ:361 Type1 Inactive DFGin 7.6116 16.3381 None -141.16, 163.83 56.43, 72.99 -75.34, 999.0 309.72, 73.83 999.0, 999.0 in-out in 9.8651 Saltbr-out 4.0704 HRD-in -63.56, -51.44 79.66, -26.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -132.89, 139.9 APE9-dihe-na -58.34, -25.0 APE8-dihe-out -56.24, -14.15 APE8-rot-out 54.17 APE67-dihe-in -68.66, -11.09 -127.46, -12.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1308 None None None XRAY 2.48 0.217 0.248 A 379.0 342.0 7 25 18 7 [[24, 308]] 1.0 3ha8 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4F9WA Q16539 5 352 360.0 LM4:403 Type1 Inactive DFGin 7.7255 16.584 None -80.52, 176.23 -63.07, 104.95 -100.59, 2.82 54.46, 75.64 130.88, -79.74 in-out in 9.4539 Saltbr-out 4.5982 HRD-in -68.07, -55.53 83.11, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.42 APE8-dihe-out -55.74, -38.36 APE8-rot-in 282.33 APE67-dihe-in -59.63, -26.4 -42.98, -44.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3918 None None None XRAY 2.0 0.173 0.216 A 383.0 336.0 12 25 13 12 [[24, 308]] 1.0 4f9w Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4FA2A Q16539 4 353 360.0 SB0:402 Type1 Inactive DFGin 8.1265 13.3665 None -98.53, 119.73 -70.7, -31.65 -138.38, 143.95 311.3, 93.7 107.84, 75.14 in-in in 9.0918 Saltbr-in 2.481 HRD-in -68.79, -53.09 81.55, -18.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -80.2 APE9-dihe-na -62.71, 131.19 APE8-dihe-out -61.7, -39.74 APE8-rot-in 283.35 APE67-dihe-in -60.81, -26.39 -57.15, -28.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.1525 APE9-dist-out 11.2807 None None None XRAY 2.0 0.174 0.215 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4fa2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4ZTHA Q16539 4 353 360.0 VVT:401 Type1 Inactive DFGin 8.3008 13.855 None -89.83, 123.18 -77.72, -39.39 -125.61, 120.62 298.26, 98.01 -83.63, -144.08 in-in in 9.2036 Saltbr-in 2.9023 HRD-in -71.36, -49.73 75.36, -10.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -91.32 APE9-dihe-na -69.69, 130.87 APE8-dihe-out -61.18, -39.46 APE8-rot-in 289.92 APE67-dihe-in -57.67, -28.49 -59.49, -25.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5913 APE9-dist-out 11.6954 None None None XRAY 2.15 0.184 0.24 A 383.0 339.0 11 25 14 11 [[24, 308]] 1.0 4zth Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9O4LA Q16539 5 353 360.0 A1B8B:402 Type1 Inactive DFGin 5.0897 15.55 None -133.08, 171.57 61.65, 21.84 -73.72, 999.0 76.92, 114.61 999.0, 999.0 in-in in 9.488 Saltbr-in 2.7441 HRD-in -65.15, -53.31 77.94, -18.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.35 APE8-rot-in 324.94 APE67-dihe-out -67.13, -12.17 -110.61, 107.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.27 0.193 0.241 A 384.0 334.0 15 25 10 15 [[24, 308]] 1.0 9o4l Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3O8PA Q16539 5 351 360.0 BMU:361 Type1 Inactive DFGin 10.8634 12.0139 None -115.52, 162.58 -99.08, -26.53 -122.71, 117.21 291.85, 138.97 -42.63, -102.67 in-out in 9.092 Saltbr-out 5.0854 HRD-in -69.17, -52.21 73.92, -4.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 3.16 APE9-dihe-na -166.83, -167.55 APE8-dihe-out -116.39, -25.53 APE8-rot-in 271.29 APE67-dihe-in -61.81, -26.71 -69.76, -21.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1587 APE9-dist-out 10.4529 D168G None None XRAY 2.1 0.218 0.276 A 360.0 336.0 11 25 14 11 [[24, 308]] 1.0 3o8p Homo sapiens CMGC_MAPK14_HUMAN CMGC 2.7e-83 285.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3OBGA Q16539 5 352 360.0 SB2:361 Type1 Inactive DFGin 8.5471 15.5472 None -95.25, 144.72 58.8, 33.65 -69.14, 75.21 999.0, 999.0 119.93, 18.42 in-in in 9.1521 Saltbr-in 2.4857 HRD-in -65.99, -57.89 82.28, -14.21 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.23 APE8-rot-in 336.97 APE67-dihe-in -54.89, -27.15 -56.97, -19.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 F169G None None XRAY 2.8 0.222 0.323 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3obg Homo sapiens CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9D75A Q16539 5 353 360.0 A1A2L:60401 Type1 Inactive DFGin 7.2315 15.7878 None -119.44, 171.6 35.49, 86.57 -63.81, 999.0 294.63, 49.65 -63.81, 999.0 in-in in 9.0602 Saltbr-in 2.5179 HRD-in -70.24, -56.4 84.64, -17.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -1.29 APE8-rot-out 180.89 APE67-dihe-out -73.6, -14.85 -63.9, 126.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.13 0.208 0.236 A 346.0 335.0 11 25 14 11 [[24, 308]] 1.0 9d75 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1e-79 273.9 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9D7NA Q16539 5 353 360.0 A1A2O:60401 Type1 Inactive DFGin 6.7111 15.4176 None -125.4, 169.42 35.27, 85.02 -62.1, 999.0 300.08, 66.43 -62.1, 999.0 in-in in 9.1287 Saltbr-in 2.51 HRD-in -66.23, -52.52 80.02, -15.24 in-out-none SNCion out-none ActLoopNT-out 6.9136 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.33, -14.88 999.0, 144.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.973 0.214 0.257 A 346.0 337.0 9 25 16 9 [[24, 308]] 1.0 9d7n Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.3e-79 273.6 1.0 301.0 301.0 167 168 169 173 175 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EWQA Q16539 5 353 360.0 MWL:402,MWL:403 Type1,Allosteric Inactive DFGin 5.0183 13.3955 None -118.78, 173.31 61.29, 10.97 -62.77, 999.0 41.58, 86.71 999.0, 999.0 in-in in 9.2208 Saltbr-in 2.7732 HRD-in -66.73, -55.27 77.04, -7.68 in-out-out SNCioo out-out ActLoopNT-out 7.2789 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -109.0, 120.47 APE9-dihe-na -53.91, -56.01 APE8-dihe-in -144.08, 143.87 APE8-rot-out 173.18 APE67-dihe-out -56.97, -22.68 -121.19, 104.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2577 None TPO180 TPO180 XRAY 2.1 0.182 0.229 A 383.0 347.0 2 25 23 2 [[24, 308]] 1.0 4ewq Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.9243 13.1341 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.5432 Saltbr-out 3.9084 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2638 None None CME162 XRAY 2.06 0.178 0.217 A 383.0 336.0 13 25 12 13 [[24, 308]] 1.0 4r3c Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9NYTA Q16539 5 353 360.0 A1B7S:402,F50:404 Type1,Allosteric Inactive DFGin 4.2601 13.0797 None -116.13, 155.51 78.56, -1.77 -37.34, 999.0 47.87, 84.48 999.0, 999.0 in-out in 9.5555 Saltbr-out 4.0805 HRD-in -71.88, -52.7 83.59, -21.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.66 APE8-dihe-out -70.34, -25.73 APE8-rot-out 87.71 APE67-dihe-in -59.45, -18.84 -59.85, -29.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5386 None None None XRAY 2.16 0.195 0.24 A 384.0 335.0 14 25 11 14 [[24, 308]] 1.0 9nyt Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HP2A Q16539 4 355 360.0 P36:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 10.3229 12.0791 None -88.89, 117.93 0.95, -90.69 -132.19, 144.91 307.84, 89.53 -100.53, 179.64 in-in in 8.9859 Saltbr-in 3.0157 HRD-in -62.69, -56.28 83.82, -16.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -83.28 APE9-dihe-na -69.46, 121.84 APE8-dihe-out -57.79, -33.94 APE8-rot-in 290.47 APE67-dihe-in -56.52, -29.08 -65.16, -23.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8086 APE9-dist-out 11.9697 None None None XRAY 2.15 0.208 0.252 A 360.0 341.0 11 25 14 11 [[24, 308]] 1.0 3hp2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HP5A Q16539 6 352 360.0 52P:401,I46:402,I46:403 Type1,Allosteric,Allosteric Inactive DFGin 6.4998 14.3567 None -122.62, 154.65 81.43, 43.95 -64.35, -69.27 340.23, 142.83 -47.68, 999.0 in-in in 8.692 Saltbr-in 3.0371 HRD-in -62.14, -57.25 84.4, -19.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, -175.23 APE9-dihe-na -178.51, 127.74 APE8-dihe-out -56.55, -39.12 APE8-rot-none 999.0 APE67-dihe-in -64.7, -27.21 -46.07, -42.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3903 None None None XRAY 2.3 0.217 0.262 A 360.0 330.0 17 25 13 12 [[24, 308]] 1.0 3hp5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH9A Q16539 5 354 360.0 IRG:401,0OQ:402 Allosteric,Type3 Inactive DFGinter 10.8996 6.2057 None -97.42, 159.57 -62.33, -60.46 -150.13, 147.17 64.11, 82.71 -78.55, 25.4 in-out in 9.4044 Saltbr-out 4.5758 HRD-in -71.05, -53.71 82.13, -21.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 115.29 APE9-dihe-na -99.26, 134.28 APE8-dihe-out -59.4, -32.47 APE8-rot-in 294.18 APE67-dihe-in -64.19, -25.37 -57.95, -25.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.356 APE9-dist-out 11.8242 None None None XRAY 2.1 0.232 0.28 A 360.0 334.0 16 25 14 11 [[24, 308]] 1.0 4eh9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GCPA Q16539 4 352 360.0 SB2:361 Type1 Inactive DFGinter 10.4711 9.2596 None -117.37, 167.72 -120.22, 32.97 -153.57, 150.38 52.4, 89.27 -67.24, 116.69 in-in in 9.1609 Saltbr-in 2.9485 HRD-in -63.02, -55.34 82.04, -15.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 176.81 APE8-rot-out 58.62 APE67-dihe-in -63.93, -20.89 -120.85, 2.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.25 0.201 0.276 A 360.0 337.0 12 25 13 12 [[24, 308]] 1.0 3gcp Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5WJJA Q16539 5 352 360.0 AQY:501 Type1 Inactive DFGinter 10.1585 9.0618 None -113.52, 161.05 -110.02, 23.38 -151.72, 163.67 53.5, 90.99 -95.62, 149.45 in-in in 9.5657 Saltbr-in 3.4445 HRD-in -66.13, -48.01 74.38, -15.21 in-out-out SNCioo out-out ActLoopNT-out 22.9602 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.37 APE8-dihe-out -54.87, -43.06 APE8-rot-in 316.01 APE67-dihe-in -61.84, -23.7 -56.22, -24.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1448 None None None XRAY 1.6 0.202 0.237 A 365.0 338.0 10 25 19 6 [[24, 308]] 1.0 5wjj Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.5e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6ANLA Q16539 4 352 360.0 T75:401 Type1 Inactive DFGinter 8.7017 9.562 None -112.8, 165.91 -107.34, -21.64 -131.97, 3.35 36.97, 78.14 70.96, -173.34 in-in in 9.9313 Saltbr-in 3.5889 HRD-in -64.58, -50.49 75.67, -10.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.9 APE8-dihe-out -67.0, -31.89 APE8-rot-in 294.98 APE67-dihe-in -56.18, -24.82 -62.08, -27.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8771 C119S,C162S None None XRAY 2.0 0.209 0.263 A 365.0 338.0 11 25 14 11 [[24, 308]] 1.0 6anl Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.5e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5ML5A Q16539 5 352 360.0 1VI:404 Type1 Inactive DFGinter 10.1363 9.2417 None -111.39, 159.42 -109.35, 34.77 -164.27, 172.15 56.08, 84.45 -90.56, 999.0 in-in in 9.3334 Saltbr-in 2.606 HRD-in -70.95, -52.33 83.04, -10.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.66 APE8-rot-in 289.06 APE67-dihe-in -53.62, -25.52 -105.11, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 A 360.0 326.0 22 25 11 14 [[24, 308]] 1.0 5ml5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HUCA Q16539 4 352 360.0 G97:362 Type1 Inactive DFGinter 10.3368 9.1786 None -109.97, 165.2 -105.06, 29.04 179.24, 164.7 62.51, 85.01 -109.68, 999.0 in-in in 9.5529 Saltbr-in 2.4424 HRD-in -73.07, -53.68 79.88, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 145.84 APE9-dihe-na -130.77, 137.71 APE8-dihe-out -61.1, -31.75 APE8-rot-in 284.73 APE67-dihe-in -65.27, -22.19 -58.7, -25.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1251 None None None XRAY 1.8 0.196 0.232 A 360.0 337.0 12 25 13 12 [[24, 308]] 1.0 3huc Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ZS5A Q16539 2 352 360.0 SB2:61000 Type1 Inactive DFGinter 10.2338 9.251 None -115.27, 172.44 -122.64, 34.9 -156.58, 162.56 53.94, 87.63 -91.34, 146.87 in-in in 9.4367 Saltbr-in 2.8264 HRD-in -66.65, -51.78 79.0, -9.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.47 APE8-dihe-out -65.94, -20.08 APE8-rot-out 57.11 APE67-dihe-in -60.59, -17.67 -110.97, -2.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4367 None None None XRAY 1.6 0.186 0.215 A 362.0 339.0 12 25 13 12 [[24, 308]] 1.0 3zs5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ZSGA Q16539 4 352 360.0 T75:400 Type1 Inactive DFGinter 9.8689 9.3824 None -112.39, 162.65 -112.67, 28.78 -156.41, 165.54 53.67, 85.81 -94.27, 155.51 in-in in 9.8169 Saltbr-in 3.4052 HRD-in -65.93, -52.33 82.35, -11.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -19.16 APE8-dihe-out -64.72, -27.97 APE8-rot-out 56.05 APE67-dihe-in -62.96, -19.39 -109.94, 3.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4087 None None None XRAY 1.89 0.191 0.233 A 362.0 337.0 12 25 13 12 [[24, 308]] 1.0 3zsg Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6HWTA Q16539 5 352 360.0 GXH:404 Type1 Inactive DFGinter 9.606 9.2491 None -109.85, 163.34 -111.83, 32.01 -158.93, 166.76 53.05, 86.7 -101.84, 157.19 in-in in 9.4049 Saltbr-in 3.1657 HRD-in -68.48, -52.76 78.69, -12.38 in-out-out SNCioo out-out ActLoopNT-out 23.1972 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.58 APE8-rot-out 199.92 APE67-dihe-in -66.05, -17.36 -114.13, 10.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.204 0.234 A 362.0 336.0 12 25 14 11 [[24, 308]] 1.0 6hwt Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6HWUA Q16539 5 353 360.0 GE5:404 Type1 Inactive DFGinter 9.5901 8.9682 None -118.08, 168.42 -117.72, 42.58 -170.41, 161.53 57.41, 87.05 -97.74, 161.01 in-in in 9.4576 Saltbr-in 2.9264 HRD-in -69.49, -51.73 75.06, -4.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 73.5 APE9-dihe-na -65.73, 137.2 APE8-dihe-out -60.1, -34.07 APE8-rot-in 274.51 APE67-dihe-in -66.54, -24.29 -62.93, -25.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2073 APE9-dist-out 11.5529 None None None XRAY 2.3 0.193 0.247 A 362.0 333.0 16 25 14 11 [[24, 308]] 1.0 6hwu Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6HWVA Q16539 5 352 360.0 GEW:404 Type1 Inactive DFGinter 9.9964 9.2856 None -112.84, 163.83 -110.3, 35.34 -165.77, 166.95 54.01, 85.28 -99.22, 157.29 in-in in 9.4943 Saltbr-in 2.8045 HRD-in -69.21, -52.62 80.0, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.66 APE8-rot-out 177.65 APE67-dihe-in -67.08, -18.22 -107.78, 6.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.18 0.197 A 362.0 336.0 12 25 13 12 [[24, 308]] 1.0 6hwv Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EHVA Q16539 5 352 360.0 0SJ:401,0SJ:402,IRG:403,0SJ:404 Type3,Allosteric,Allosteric,Allosteric Inactive DFGinter 10.9229 6.2755 None -99.66, 162.35 -69.64, -55.96 -152.93, 157.53 62.39, 91.72 -108.25, -179.88 in-none in 9.2374 Saltbr-none 999.0 HRD-in -69.34, -50.13 82.95, -13.29 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 107.52 APE9-dihe-na -78.18, 127.1 APE8-dihe-out -52.4, -41.18 APE8-rot-in 282.24 APE67-dihe-in -64.93, -23.91 -55.78, -30.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.946 APE9-dist-out 11.0047 None None None XRAY 1.6 0.223 0.252 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 4ehv Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9CJ3A Q16539 4 352 360.0 PDO:408,A1AWV:410 Allosteric,Type2 Inactive DFGout 15.2727 9.3064 BBAminus -138.7, -172.72 -146.54, 104.28 -50.46, -45.96 262.7, 81.94 68.22, 25.32 in-in in 8.4984 Saltbr-in 2.8294 HRD-in -69.96, -52.7 76.88, -14.52 in-out-out SNCioo out-out ActLoopNT-out 16.5343 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -126.47, 117.16 APE9-dihe-na -77.09, 129.32 APE8-dihe-out -52.48, -42.5 APE8-rot-in 292.76 APE67-dihe-in -62.21, -22.05 -58.1, -28.96 APE12-dist-out 14.7632 APE11-dist-in 12.8512 APE10-dist-out 12.7487 APE9-dist-out 10.3175 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.144 0.189 A 360.0 344.0 5 25 20 5 [[24, 308]] 1.0 9cj3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6QDZA Q16539 5 352 360.0 I46:401,HYK:402 Allosteric,Type2 Inactive DFGout 14.9123 9.0812 BBAminus -134.77, -179.97 -142.81, 109.12 -72.73, -21.08 264.45, 91.98 63.26, 999.0 in-in in 8.4999 Saltbr-in 2.7579 HRD-in -75.35, -56.13 84.01, -14.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.14 APE8-dihe-out -58.44, -38.6 APE8-rot-in 261.35 APE67-dihe-in -64.54, -27.76 -61.68, -25.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4049 None None None XRAY 1.73 0.206 0.246 A 362.0 327.0 21 25 12 13 [[24, 308]] 1.0 6qdz Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6QE1A Q16539 5 352 360.0 I46:401,HYW:402 Allosteric,Type2 Inactive DFGout 14.5033 9.1773 BBAminus -141.03, -172.04 -146.99, 109.37 -71.94, -17.35 270.92, 90.33 65.73, 999.0 in-in in 8.7612 Saltbr-in 2.6233 HRD-in -65.85, -55.55 81.72, -12.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 126.37 APE8-dihe-out -53.58, -40.3 APE8-rot-in 269.79 APE67-dihe-in -62.76, -30.98 -60.8, -26.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3191 None None None XRAY 1.85 0.181 0.222 A 362.0 328.0 20 25 12 13 [[24, 308]] 1.0 6qe1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GCQA Q16539 4 355 360.0 1BU:401 Type2 Inactive DFGout 14.6646 10.6705 BBAminus -139.23, -170.27 -145.46, 100.56 -65.8, -17.82 263.24, 85.46 68.21, 999.0 in-out in 9.7205 Saltbr-out 5.0738 HRD-in -70.7, -53.82 76.41, -13.25 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 112.05 APE9-dihe-na -79.36, 140.98 APE8-dihe-out -65.6, -31.05 APE8-rot-in 287.72 APE67-dihe-in -59.4, -25.34 -65.07, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1048 C119S,C162S,A172C,F327L None None XRAY 2.0 0.219 0.27 A 360.0 337.0 15 25 13 12 [[24, 308]] 1.0 3gcq Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GCSA Q16539 5 352 360.0 BAX:401 Type2 Inactive DFGout 13.802 11.2196 BBAminus -148.91, -179.17 -135.91, 107.56 -69.03, -19.52 281.41, 117.73 85.38, 999.0 in-out in 9.7012 Saltbr-out 5.0624 HRD-in -66.45, -55.11 82.51, -13.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.89 APE8-rot-in 262.05 APE67-dihe-in -67.03, -18.78 -100.06, 9.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.1 0.204 0.262 A 360.0 331.0 17 25 11 14 [[24, 308]] 1.0 3gcs Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GCVA Q16539 4 353 360.0 SS6:361 Type2 Inactive DFGout 15.3653 12.0708 BBAminus -152.67, -170.82 -110.18, 113.34 -93.28, 22.0 252.44, 132.33 49.52, -127.32 in-in in 9.2779 Saltbr-in 2.6734 HRD-in -73.49, -50.16 80.46, -18.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.63 APE9-dihe-na -79.69, 139.68 APE8-dihe-out -61.27, -36.62 APE8-rot-in 278.06 APE67-dihe-in -71.87, -21.97 -66.32, -17.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.6551 APE9-dist-out 10.9984 C119S,C162S,A172C,F327L None None XRAY 2.3 0.199 0.254 A 360.0 338.0 12 25 15 10 [[24, 308]] 1.0 3gcv Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV3A Q16539 4 353 360.0 R49:361 Type2 Inactive DFGout 14.6691 10.0538 BBAminus -138.69, -175.75 -140.2, 99.87 -64.25, -13.35 254.6, 108.31 -167.95, 999.0 in-in in 9.4709 Saltbr-in 3.1771 HRD-in -71.8, -52.19 74.58, -14.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 117.52 APE9-dihe-na -88.84, 141.45 APE8-dihe-out -61.65, -30.9 APE8-rot-in 283.55 APE67-dihe-in -62.55, -24.37 -61.18, -30.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0565 C119S,C162S,A172C,F327L None None XRAY 2.0 0.233 0.3 A 360.0 335.0 15 25 13 12 [[24, 308]] 1.0 3hv3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LFEA Q16539 4 353 360.0 Z84:361 Type2 Inactive DFGout 13.8532 10.6121 BBAminus -143.39, -175.95 -148.84, 101.16 -68.77, -23.71 286.29, 130.19 55.28, 999.0 in-in in 9.2081 Saltbr-in 2.9986 HRD-in -66.22, -52.7 79.44, -21.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.9 APE8-dihe-out -73.25, -29.21 APE8-rot-in 294.69 APE67-dihe-in -59.42, -21.9 -66.48, -18.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6744 C119S,C162S,A172C,F327L None None XRAY 2.3 0.217 0.274 A 360.0 334.0 16 25 12 13 [[24, 308]] 1.0 3lfe Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LFFA Q16539 5 352 360.0 Z83:362 Type2 Inactive DFGout 13.7444 9.2828 BBAminus -133.71, -177.31 -147.05, 100.37 -58.09, -30.94 280.16, 120.96 67.43, 999.0 in-in in 8.413 Saltbr-in 2.8332 HRD-in -66.74, -56.1 82.28, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.23 APE8-dihe-out -53.58, -33.4 APE8-rot-in 266.57 APE67-dihe-in -64.59, -22.45 -107.2, 0.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.9371 C119S,C162S,A172C,F327L None None XRAY 1.5 0.2 0.225 A 360.0 335.0 13 25 12 13 [[24, 308]] 1.0 3lff Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3PG3A Q16539 4 353 360.0 DG7:362 Type2 Inactive DFGout 13.0987 10.5554 BBAminus -137.98, -176.41 -143.4, 105.33 -78.6, -12.21 284.63, 130.22 62.45, 999.0 out-out out 10.0654 Saltbr-out 4.9546 HRD-in -65.37, -57.04 80.78, -17.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.31 APE8-dihe-out -77.9, -6.45 APE8-rot-out 68.06 APE67-dihe-in -64.35, -20.06 -105.87, -4.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1627 C119S,C162S,A172C,F327L None None XRAY 2.0 0.221 0.261 A 360.0 337.0 13 25 12 13 [[24, 308]] 1.0 3pg3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6SFIA Q16539 4 353 360.0 LB5:401 Type2 Inactive DFGout 13.3937 10.6179 BBAminus -129.5, -179.89 -143.16, 112.38 -90.24, 3.11 298.38, 125.14 -102.41, -164.82 in-in in 9.1561 Saltbr-in 2.8191 HRD-in -70.1, -55.69 77.65, -7.32 in-out-out SNCioo out-out ActLoopNT-out 6.0401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -68.49 APE8-dihe-in -119.24, 141.74 APE8-rot-out 178.05 APE67-dihe-in -68.18, -20.08 -104.43, 11.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4088 None None None XRAY 1.6 0.176 0.203 A 361.0 340.0 10 25 15 10 [[24, 308]] 1.0 6sfi Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6SFJA Q16539 4 353 360.0 LBB:401 Type2 Inactive DFGout 13.7245 10.6811 BBAminus -123.13, 178.73 -142.95, 116.4 -91.09, 8.2 302.11, 122.57 58.02, -143.48 in-in in 9.057 Saltbr-in 2.7594 HRD-in -65.53, -58.09 80.46, -16.37 in-out-out SNCioo out-out ActLoopNT-out 19.1753 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 102.4 APE9-dihe-na -70.83, 128.75 APE8-dihe-out -52.3, -41.24 APE8-rot-in 279.44 APE67-dihe-in -65.41, -19.81 -40.73, -45.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.683 APE9-dist-out 11.0277 None None None XRAY 1.95 0.187 0.227 A 361.0 341.0 9 25 16 9 [[24, 308]] 1.0 6sfj Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6SFOA Q16539 5 352 360.0 LBE:402 Type2 Inactive DFGout 13.107 10.3486 BBAminus -133.23, 176.29 -141.54, 104.3 -74.14, -17.59 288.97, 121.95 -93.86, 999.0 in-in in 9.2345 Saltbr-in 2.8873 HRD-in -66.53, -57.57 78.56, -10.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 77.52 APE9-dihe-na -59.94, 128.18 APE8-dihe-out -53.66, -40.71 APE8-rot-in 281.51 APE67-dihe-in -59.09, -32.81 -60.23, -32.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9439 None None None XRAY 1.75 0.193 0.236 A 361.0 334.0 14 25 13 12 [[24, 308]] 1.0 6sfo Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6ZWPA Q16539 4 353 360.0 OE8:401 Type2 Inactive DFGout 13.1697 10.4903 BBAminus -143.26, -177.15 -138.64, 100.63 -74.29, -17.88 287.51, 117.46 71.05, 999.0 in-in in 9.0912 Saltbr-in 2.6302 HRD-in -68.6, -58.63 80.97, -13.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -90.87 APE9-dihe-na -64.71, 121.83 APE8-dihe-out -50.5, -42.84 APE8-rot-in 294.97 APE67-dihe-in -56.58, -32.08 -60.33, -32.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6461 None None None XRAY 1.9 0.215 0.251 A 361.0 328.0 22 25 13 12 [[24, 308]] 1.0 6zwp Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3CTQA Q16539 5 352 360.0 337:1 Type2 Inactive DFGout 14.2256 10.9769 BBAminus -131.82, -176.84 -153.58, 135.58 -106.9, 11.33 302.88, 150.47 51.03, 999.0 in-in in 9.0033 Saltbr-in 2.6384 HRD-in -63.28, -57.42 77.14, -7.58 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 125.24 APE9-dihe-na -79.17, 136.28 APE8-dihe-out -57.02, -39.72 APE8-rot-out 76.68 APE67-dihe-in -53.14, -28.61 -51.51, -43.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7603 None None None XRAY 1.95 0.23 0.269 A 348.0 336.0 12 25 13 12 [[24, 308]] 1.0 3ctq Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.8e-85 291.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5MZ3A Q16539 4 353 360.0 8EN:401 Type2 Inactive DFGout 12.3243 10.0727 BBAminus -138.69, -176.72 -144.33, 92.3 -89.87, 8.58 281.81, 11.32 -64.84, 131.14 in-in in 9.3713 Saltbr-in 2.7278 HRD-in -65.21, -54.32 77.27, -16.15 in-out-out SNCioo out-out ActLoopNT-out 15.7602 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -131.22, 136.32 APE9-dihe-na -62.44, -24.76 APE8-dihe-out -59.5, -22.25 APE8-rot-out 57.3 APE67-dihe-in -63.85, -25.43 -113.93, -15.51 APE12-dist-out 19.8351 APE11-dist-out 21.014 APE10-dist-out 15.3944 APE9-dist-out 11.5273 C162S None None XRAY 2.15 0.166 0.197 A 369.0 350.0 0 25 25 0 [[24, 308]] 1.0 5mz3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.7e-84 289.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HEGA Q16539 5 352 360.0 BAX:1 Type2 Inactive DFGout 13.9801 10.4162 BBAminus -138.78, -176.3 -143.83, 112.16 -66.98, -96.1 288.65, 119.82 123.84, 999.0 in-in in 9.6179 Saltbr-in 3.0077 HRD-in -67.99, -50.51 67.42, -7.32 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -161.71, 88.05 APE9-dihe-na -78.71, 132.75 APE8-dihe-out -59.19, -30.56 APE8-rot-in 282.81 APE67-dihe-in -52.86, -23.91 -65.83, -36.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8536 None None None XRAY 2.2 0.24 0.309 A 348.0 333.0 15 25 14 11 [[24, 308]] 1.0 3heg Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.2e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1W83A Q16539 4 355 360.0 L11:1355 Type2 Inactive DFGout 14.7052 11.6052 BBAminus -142.16, -178.02 -126.62, 107.98 -77.01, -19.08 266.9, 115.16 -50.83, 116.59 in-in in 9.0006 Saltbr-in 2.7053 HRD-in -57.58, -54.74 77.55, -14.6 in-out-out SNCioo out-out ActLoopNT-out 15.7211 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -123.36, 133.64 APE9-dihe-na -56.55, -24.42 APE8-dihe-out -67.3, -13.21 APE8-rot-out 68.23 APE67-dihe-in -60.67, -28.08 -119.99, -15.67 APE12-dist-out 20.2746 APE11-dist-out 21.3637 APE10-dist-out 15.7805 APE9-dist-out 11.7822 None None None XRAY 2.5 0.233 0.322 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w83 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WBNA Q16539 4 355 360.0 L09:1355 Type2 Inactive DFGout 14.7526 12.4497 BBAminus -144.68, -164.93 -135.23, 106.6 -72.63, -9.67 292.92, 86.74 -55.54, 132.36 in-in in 9.2626 Saltbr-in 3.053 HRD-in -70.35, -54.36 78.68, -15.66 in-out-out SNCioo out-out ActLoopNT-out 15.8194 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.23, 129.6 APE9-dihe-na -55.11, -23.17 APE8-dihe-out -56.32, -28.39 APE8-rot-out 52.74 APE67-dihe-in -64.32, -21.9 -108.48, -14.84 APE12-dist-out 20.3417 APE11-dist-out 21.4319 APE10-dist-out 15.9316 APE9-dist-out 11.7105 None None None XRAY 2.4 0.181 0.244 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbn Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3D83A Q16539 4 352 360.0 GK6:401 Type2 Inactive DFGout 14.6482 11.9189 BBAminus -137.19, -168.47 -140.74, 108.25 -84.28, -6.57 283.56, 93.12 -53.93, 125.26 in-in in 9.1168 Saltbr-in 2.6767 HRD-in -73.2, -53.34 72.61, -11.66 in-out-out SNCioo out-out ActLoopNT-out 15.2929 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.95, 133.17 APE9-dihe-na -61.38, -18.76 APE8-dihe-out -61.88, -18.27 APE8-rot-out 59.42 APE67-dihe-in -60.96, -22.43 -116.21, -20.51 APE12-dist-out 20.4469 APE11-dist-out 21.7569 APE10-dist-out 16.1089 APE9-dist-out 11.8046 None None CSO119,CSO162 XRAY 1.9 0.177 0.218 A 360.0 349.0 0 25 25 0 [[24, 308]] 1.0 3d83 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9CJ4A Q16539 5 352 360.0 B96:401 Type2 Inactive DFGout 15.34 9.2502 BBAminus -140.85, -174.89 -146.31, 104.15 -52.61, -47.17 266.98, 78.45 63.05, 28.98 in-in in 8.7329 Saltbr-in 2.7511 HRD-in -68.26, -51.49 71.88, -11.93 in-out-out SNCioo out-out ActLoopNT-out 16.6629 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -132.6, 106.16 APE9-dihe-na -83.05, 127.8 APE8-dihe-out -48.48, -41.43 APE8-rot-in 291.57 APE67-dihe-in -63.37, -26.47 -62.41, -24.06 APE12-dist-out 16.029 APE11-dist-out 15.1827 APE10-dist-out 13.118 APE9-dist-out 10.6363 None TPO180,PTR182 TPO180,PTR182 XRAY 1.8 0.162 0.199 A 360.0 336.0 12 25 18 7 [[24, 308]] 1.0 9cj4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GCUA Q16539 4 352 360.0 R48:401 Type2 Inactive DFGout 14.5429 11.8091 BBAminus -146.91, -162.95 -136.64, 100.46 -77.49, -11.4 270.17, 105.48 -56.49, 136.97 in-in in 8.9542 Saltbr-in 2.8868 HRD-in -67.23, -51.11 76.39, -20.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 102.53 APE9-dihe-na -59.15, 138.32 APE8-dihe-out -60.95, -36.87 APE8-rot-in 271.19 APE67-dihe-in -60.94, -27.8 -58.38, -29.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5825 APE9-dist-out 11.0643 None None None XRAY 2.1 0.19 0.235 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3gcu Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GCUB Q16539 5 352 360.0 R48:401 Type2 Inactive DFGout 14.7976 11.6309 BBAminus -128.97, -177.2 -130.82, 102.93 -76.01, -7.46 275.51, 99.04 -57.11, 134.5 in-in in 8.843 Saltbr-in 2.6741 HRD-in -69.2, -51.89 79.51, -18.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 90.91 APE9-dihe-na -82.69, 132.53 APE8-dihe-out -52.31, -42.31 APE8-rot-in 283.62 APE67-dihe-in -63.1, -25.88 -54.06, -31.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.5094 APE9-dist-out 11.1021 None None None XRAY 2.1 0.19 0.235 B 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3gcu Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV4A Q16539 4 352 360.0 L51:361 Type2 Inactive DFGout 14.7347 11.6287 BBAminus -142.67, -157.85 -140.68, 86.15 -62.83, -22.45 270.53, 99.57 -47.3, 133.93 in-in in 8.8696 Saltbr-in 3.0093 HRD-in -66.37, -49.94 75.86, -15.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 47.43 APE9-dihe-na -51.5, 140.47 APE8-dihe-out -61.26, -39.48 APE8-rot-in 266.64 APE67-dihe-in -57.18, -30.17 -58.29, -24.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.842 APE9-dist-out 11.2826 None None None XRAY 2.6 0.197 0.271 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3hv4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV4B Q16539 5 352 360.0 L51:361 Type2 Inactive DFGout 15.7924 12.0072 BBAminus -145.26, -175.16 -120.86, 83.83 -51.51, -19.7 265.81, 75.93 -56.18, 124.85 in-in in 8.8621 Saltbr-in 2.8135 HRD-in -65.01, -48.44 76.59, -19.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 74.36 APE9-dihe-na -74.32, 124.34 APE8-dihe-out -50.56, -46.12 APE8-rot-in 289.55 APE67-dihe-in -60.36, -22.87 -26.56, -50.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.0304 APE9-dist-out 11.2607 None None None XRAY 2.6 0.197 0.271 B 360.0 338.0 10 25 15 10 [[24, 308]] 1.0 3hv4 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV5A Q16539 4 352 360.0 R24:361 Type2 Inactive DFGout 14.524 11.8501 BBAminus -149.06, -161.59 -134.02, 95.31 -72.2, -13.6 276.5, 110.91 -63.01, 141.02 in-in in 8.8866 Saltbr-in 2.9262 HRD-in -71.92, -48.65 78.83, -18.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 70.02 APE9-dihe-na -69.23, 130.56 APE8-dihe-out -52.66, -36.6 APE8-rot-in 268.08 APE67-dihe-in -58.06, -29.94 -67.56, -24.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.5095 APE9-dist-out 11.1603 None None None XRAY 2.25 0.19 0.26 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3hv5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV5B Q16539 4 352 360.0 R24:361 Type2 Inactive DFGout 14.9875 11.9865 BBAminus -143.61, -171.37 -127.57, 96.09 -68.49, -17.63 274.9, 105.84 -67.24, 132.58 in-in in 8.7939 Saltbr-in 2.7692 HRD-in -68.01, -49.62 79.57, -9.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 94.22 APE9-dihe-na -73.49, 125.26 APE8-dihe-out -48.98, -52.43 APE8-rot-in 285.06 APE67-dihe-in -67.34, -20.49 -29.85, -42.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.9937 APE9-dist-out 11.0049 None None None XRAY 2.25 0.19 0.26 B 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 3hv5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV6A Q16539 4 352 360.0 R39:361 Type2 Inactive DFGout 14.7079 9.1265 BBAminus -136.88, -171.81 -147.79, 102.81 -62.49, -26.59 256.35, 92.54 82.94, 999.0 in-out in 9.2791 Saltbr-out 5.2211 HRD-in -66.15, -59.41 84.5, -16.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 105.05 APE9-dihe-na -67.09, 136.12 APE8-dihe-out -58.82, -42.73 APE8-rot-in 268.25 APE67-dihe-in -61.59, -24.03 -51.22, -33.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3016 None None None XRAY 1.95 0.21 0.254 A 360.0 331.0 18 25 13 12 [[24, 308]] 1.0 3hv6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2BAKA Q16539 5 353 360.0 AQZ:401 Type2 Inactive DFGout 14.0717 11.4156 BBAminus -143.45, -169.82 -148.04, 89.96 -71.5, -10.34 301.49, 112.56 74.77, 999.0 in-in in 9.3031 Saltbr-in 2.7314 HRD-in -70.02, -52.87 74.17, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 100.58 APE9-dihe-na -65.01, 135.39 APE8-dihe-out -56.44, -41.69 APE8-rot-in 273.92 APE67-dihe-in -57.73, -27.0 -56.68, -27.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1896 None None None XRAY 2.2 0.22 0.25 A 365.0 334.0 15 25 13 12 [[24, 308]] 1.0 2bak Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4A9YA Q16539 5 353 360.0 AQZ:1354 Type2 Inactive DFGout 14.0717 11.4156 BBAminus -143.45, -169.82 -148.04, 89.96 -71.5, -10.34 301.49, 112.96 74.77, 999.0 in-in in 9.3031 Saltbr-in 2.7314 HRD-in -70.02, -52.87 74.17, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 100.58 APE9-dihe-na -65.01, 135.39 APE8-dihe-out -56.44, -41.69 APE8-rot-in 273.92 APE67-dihe-in -57.73, -27.0 -56.68, -27.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1896 None None None XRAY 2.2 0.22 0.25 A 365.0 334.0 15 25 13 12 [[24, 308]] 1.0 4a9y Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4AA0A Q16539 5 352 360.0 AA0:1353 Type2 Inactive DFGout 14.6817 11.477 BBAminus -143.28, -166.01 -144.55, 110.59 -86.89, -1.57 289.14, 127.7 54.63, 999.0 in-in in 9.3194 Saltbr-in 2.617 HRD-in -66.16, -56.66 81.83, -14.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 119.24 APE9-dihe-na -72.72, 134.51 APE8-dihe-out -52.65, -40.98 APE8-rot-in 289.14 APE67-dihe-in -62.58, -23.78 -58.6, -28.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9569 None None None XRAY 1.8 0.213 0.255 A 365.0 329.0 19 25 13 12 [[24, 308]] 1.0 4aa0 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3E93A Q16539 4 353 360.0 19B:361 Type2 Inactive DFGout 14.038 11.4248 BBAminus -135.93, -177.11 -132.75, 104.83 -82.94, 5.62 292.66, 110.23 -52.26, 119.09 in-in in 9.0918 Saltbr-in 2.7093 HRD-in -67.09, -55.84 76.8, -18.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -143.6, 133.73 APE9-dihe-na -64.58, -15.28 APE8-dihe-out -65.21, -15.66 APE8-rot-out 52.25 APE67-dihe-in -60.51, -24.62 -117.51, -21.31 APE12-dist-out 19.7381 APE11-dist-out 21.101 APE10-dist-out 15.5016 APE9-dist-out 11.6946 None None CSO162 XRAY 2.0 0.171 0.228 A 371.0 347.0 3 25 22 3 [[24, 308]] 1.0 3e93 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.5e-85 291.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3KQ7A Q16539 5 352 360.0 KQ7:361 Type2 Inactive DFGout 14.1565 11.9477 BBAminus -131.22, -173.69 -137.41, 105.18 -78.86, -5.42 289.01, 106.12 -55.69, 128.77 in-in in 8.8894 Saltbr-in 2.7547 HRD-in -74.51, -54.27 77.08, -12.8 in-out-out SNCioo out-out ActLoopNT-out 16.3329 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.38, 132.2 APE9-dihe-na -60.0, -17.54 APE8-dihe-out -70.63, -8.61 APE8-rot-out 52.04 APE67-dihe-in -65.18, -21.16 -118.62, -19.11 APE12-dist-out 20.1698 APE11-dist-out 21.4841 APE10-dist-out 15.9258 APE9-dist-out 11.5399 None None None XRAY 1.8 0.19 0.233 A 380.0 348.0 0 25 25 0 [[24, 308]] 1.0 3kq7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3GI3A Q16539 5 352 360.0 B10:391 Type2 Inactive DFGout 15.003 9.7282 BBAminus -144.29, -176.79 -144.27, 112.55 -73.33, 53.52 274.48, 85.31 63.16, 999.0 in-in in 9.1348 Saltbr-in 3.4296 HRD-in -67.61, -56.78 77.91, -15.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 159.14 APE9-dihe-na -51.99, 118.6 APE8-dihe-out -61.48, -51.94 APE8-rot-out 77.45 APE67-dihe-in -60.43, -23.14 -53.99, -38.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5145 None None None XRAY 2.4 0.23 0.289 A 360.0 330.0 18 25 13 12 [[24, 308]] 1.0 3gi3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.7e-83 286.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3IW8A Q16539 4 352 360.0 HIZ:361 Type3 Inactive DFGout 14.3393 10.7484 BBAminus -128.77, 173.15 -144.49, 96.52 -69.13, -29.38 264.26, 95.46 -57.05, 999.0 in-in in 9.5835 Saltbr-in 3.1837 HRD-in -68.87, -52.0 80.48, -15.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.92 APE8-dihe-out -64.98, -16.01 APE8-rot-out 58.5 APE67-dihe-in -67.61, -18.84 -96.57, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.89 C119S,C162S,A172C,F327L None None XRAY 2.0 0.22 0.298 A 360.0 334.0 15 25 12 13 [[24, 308]] 1.0 3iw8 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LFBA Q16539 4 353 360.0 Z87:361 Type3 Inactive DFGout 13.5059 8.6694 BBAminus -137.91, -175.41 -148.69, 98.28 -75.6, 80.49 288.48, 128.29 -32.77, 999.0 in-in in 8.8689 Saltbr-in 3.3022 HRD-in -68.86, -47.3 79.01, -11.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 142.13 APE8-dihe-out -63.54, -31.96 APE8-rot-in 292.75 APE67-dihe-in -68.43, -9.24 -55.41, -18.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7626 C119S,C162S,A172C,F327L None None XRAY 2.6 0.236 0.32 A 360.0 333.0 17 25 12 13 [[24, 308]] 1.0 3lfb Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LFCA Q16539 4 354 360.0 Z86:361 Type3 Inactive DFGout 15.0835 10.4692 BBAminus -140.93, 172.03 -136.7, 104.03 -73.11, 19.87 257.43, 81.27 31.49, 999.0 in-in in 9.185 Saltbr-in 2.9144 HRD-in -68.27, -48.31 75.76, -5.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.38 APE8-dihe-out -70.67, -45.62 APE8-rot-in 307.9 APE67-dihe-in -82.24, -9.74 -64.34, 0.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7803 C119S,C162S,A172C,F327L None None XRAY 2.8 0.242 0.326 A 360.0 334.0 17 25 12 13 [[24, 308]] 1.0 3lfc Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3NNVA Q16539 5 352 360.0 437:355 Type3 Inactive DFGout 14.5716 9.2585 BBAminus -142.55, -173.27 -145.34, 106.59 -51.19, -52.47 263.96, 85.79 66.07, 29.58 in-in in 8.439 Saltbr-in 2.6549 HRD-in -68.73, -54.43 79.33, -18.5 in-out-out SNCioo out-out ActLoopNT-out 15.2643 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.26, 134.3 APE9-dihe-na -61.65, -19.68 APE8-dihe-out -63.7, -16.87 APE8-rot-out 57.56 APE67-dihe-in -65.56, -22.72 -113.46, -23.13 APE12-dist-out 19.8237 APE11-dist-out 21.1003 APE10-dist-out 15.4487 APE9-dist-out 11.7056 None None None XRAY 2.1 0.188 0.235 A 354.0 348.0 0 25 25 0 [[24, 308]] 1.0 3nnv Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3NNXA Q16539 5 352 360.0 EDD:355 Type3 Inactive DFGout 14.2 9.2163 BBAminus -135.6, -177.89 -139.59, 108.47 -57.96, -45.51 273.61, 91.9 59.97, 25.47 in-in in 8.607 Saltbr-in 2.8874 HRD-in -71.36, -53.19 82.69, -16.33 in-out-out SNCioo out-out ActLoopNT-out 17.2369 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -88.62, 104.06 APE9-dihe-na -72.31, 123.14 APE8-dihe-out -62.65, -30.04 APE8-rot-out 108.29 APE67-dihe-in -62.69, -25.91 -61.93, -24.39 APE12-dist-none 999.0 APE11-dist-in 12.9915 APE10-dist-out 12.8716 APE9-dist-out 10.6831 None PTR182 PTR182 XRAY 2.28 0.222 0.285 A 354.0 337.0 11 25 18 7 [[24, 308]] 1.0 3nnx Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1W82A Q16539 4 355 360.0 L10:1356 Type3 Inactive DFGout 14.0689 9.1738 BBAminus -147.9, -178.18 -145.43, 99.06 -49.9, -42.31 277.8, 103.87 66.12, 29.05 in-in in 8.9178 Saltbr-in 2.5493 HRD-in -69.25, -58.44 82.74, -19.28 in-out-out SNCioo out-out ActLoopNT-out 15.3244 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.24, 132.47 APE9-dihe-na -61.88, -19.44 APE8-dihe-out -63.75, -20.33 APE8-rot-out 53.66 APE67-dihe-in -64.33, -18.99 -112.97, -18.8 APE12-dist-out 19.6069 APE11-dist-out 20.9631 APE10-dist-out 15.2637 APE9-dist-out 11.814 None None None XRAY 2.2 0.174 0.235 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1w82 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WBVA Q16539 4 355 360.0 LI3:1355 Type3 Inactive DFGout 13.8114 10.6204 BBAminus -134.67, -171.45 -143.3, 105.97 -79.38, -25.77 282.68, 115.07 -27.13, 80.56 in-in in 9.4434 Saltbr-in 2.6654 HRD-in -73.41, -55.51 76.97, -15.29 in-out-out SNCioo out-out ActLoopNT-out 15.6716 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -135.39, 133.7 APE9-dihe-na -61.21, -22.55 APE8-dihe-out -53.62, -26.32 APE8-rot-in 304.67 APE67-dihe-in -66.43, -19.77 -114.84, -13.62 APE12-dist-out 19.7295 APE11-dist-out 21.0278 APE10-dist-out 15.3447 APE9-dist-out 11.8668 None None None XRAY 2.0 0.18 0.233 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbv Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HV7A Q16539 5 352 360.0 1AU:361 Type3 Inactive DFGout 14.4625 9.1323 BBAminus -135.81, -172.79 -148.84, 101.39 -62.36, -41.87 280.67, 103.39 51.74, 88.53 in-in in 8.8667 Saltbr-in 3.1249 HRD-in -79.33, -51.9 86.38, -21.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 109.97 APE9-dihe-na -61.86, 118.1 APE8-dihe-out -35.91, -46.58 APE8-rot-in 283.34 APE67-dihe-in -67.06, -23.86 -60.08, -25.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.9481 APE9-dist-out 11.1302 None None None XRAY 2.4 0.208 0.279 A 360.0 330.0 18 25 14 11 [[24, 308]] 1.0 3hv7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2BAJA Q16539 2 353 360.0 1PP:60401 Type3 Inactive DFGout 14.4174 9.2517 BBAminus -151.05, 178.08 -142.27, 101.23 -49.29, -43.08 274.53, 77.37 57.96, 32.94 in-in in 8.4421 Saltbr-in 2.7989 HRD-in -68.1, -55.57 80.28, -12.3 in-out-out SNCioo out-out ActLoopNT-out 15.5807 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -142.01, 130.0 APE9-dihe-na -85.9, 148.12 APE8-dihe-out -78.24, -30.99 APE8-rot-out 234.7 APE67-dihe-in -63.24, -22.11 -66.59, -20.46 APE12-dist-in 12.6679 APE11-dist-out 17.2094 APE10-dist-out 14.6457 APE9-dist-out 11.5968 None None None XRAY 2.25 0.221 0.303 A 365.0 334.0 15 25 25 0 [[24, 308]] 1.0 2baj Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3O8UA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.7961 9.3058 BBAminus -146.29, -170.4 -144.05, 102.12 -67.29, -15.97 286.91, 115.68 99.79, 999.0 in-in in 9.3312 Saltbr-in 3.3635 HRD-in -63.28, -51.7 74.53, -20.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.38 APE8-dihe-out -70.85, -30.66 APE8-rot-in 258.69 APE67-dihe-in -65.11, -25.9 -59.1, -20.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1038 F169Y None None XRAY 2.1 0.224 0.285 A 360.0 332.0 16 25 12 13 [[24, 308]] 1.0 3o8u Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.3e-84 288.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3OBJA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 14.513 11.366 BBAminus -154.08, -178.49 -133.48, 111.98 -61.66, -36.04 255.28, 56.42 -103.05, -92.49 in-out in 9.3041 Saltbr-out 5.8023 HRD-in -72.07, -52.81 76.05, -16.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.04 APE8-dihe-out -70.24, -30.65 APE8-rot-out 197.91 APE67-dihe-in -70.14, -17.15 -63.21, -16.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9735 F169R None None XRAY 2.4 0.22 0.287 A 360.0 332.0 16 25 13 12 [[24, 308]] 1.0 3obj Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-83 286.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3K3IA Q16539 5 352 360.0 JZJ:1,I46:353,I46:2 Type3,Allosteric,Allosteric Inactive DFGout 13.8744 9.8725 BBAminus -143.79, -170.14 -141.75, 114.95 -78.16, -16.52 274.05, 114.76 49.78, 999.0 in-in in 9.3253 Saltbr-in 2.6305 HRD-in -66.69, -52.65 76.63, -11.32 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 118.08 APE9-dihe-na -84.9, 132.08 APE8-dihe-out -50.88, -42.58 APE8-rot-in 276.73 APE67-dihe-in -63.3, -21.91 -56.89, -25.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1293 None None None XRAY 1.7 0.196 0.242 A 350.0 332.0 16 25 13 12 [[24, 308]] 1.0 3k3i Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.3e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5N64A Q16539 5 354 360.0 8OH:401 Allosteric Inactive DFGout 12.5487 10.0684 None -116.64, 171.43 -157.28, 152.62 -127.34, 999.0 304.62, 91.62 999.0, 999.0 in-in in 9.6572 Saltbr-in 3.1212 HRD-in -70.47, -53.46 79.07, -15.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 105.89 APE9-dihe-na -76.48, 137.46 APE8-dihe-out -63.78, -33.52 APE8-rot-in 290.65 APE67-dihe-in -60.59, -22.62 -65.11, -26.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4769 None None None XRAY 2.4 0.206 0.241 A 360.0 329.0 21 25 12 13 [[24, 308]] 1.0 5n64 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5N66A Q16539 6 353 360.0 BW1:401,B96:402 Allosteric,Type2 Inactive DFGout 15.2968 8.4235 None -139.77, 175.86 -130.8, 80.71 -75.53, 999.0 203.45, 0.89 999.0, 999.0 in-in in 9.3082 Saltbr-in 3.0902 HRD-in -75.99, -50.95 71.47, -11.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 102.5 APE9-dihe-na -77.27, 137.11 APE8-dihe-out -68.28, -33.89 APE8-rot-in 297.4 APE67-dihe-in -63.75, -24.17 -62.85, -21.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8031 None None None XRAY 2.4 0.208 0.238 A 360.0 332.0 16 25 12 13 [[24, 308]] 1.0 5n66 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH8A Q16539 4 354 360.0 IRG:401,0OP:402,0OP:403 Allosteric,Type3,Type1 Inactive DFGout 11.6887 12.5312 None -126.98, -173.26 -129.13, 140.31 68.37, 999.0 306.63, 121.42 999.0, 999.0 in-in in 9.382 Saltbr-in 3.0908 HRD-in -73.46, -51.4 85.92, -19.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 158.35 APE9-dihe-na -105.67, 133.81 APE8-dihe-out -60.04, -38.46 APE8-rot-in 291.54 APE67-dihe-in -62.35, -25.05 -51.18, -35.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2127 None None None XRAY 2.2 0.242 0.282 A 360.0 336.0 15 25 12 13 [[24, 308]] 1.0 4eh8 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2FSMX Q16539 4 352 360.0 No_ligand No_ligand Inactive DFGout 14.2322 10.8641 None -99.78, 158.41 -80.16, -38.23 18.46, 999.0 268.72, 29.23 999.0, 999.0 in-in in 9.7893 Saltbr-in 3.0064 HRD-in -70.84, -53.29 76.61, -8.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.48 APE8-dihe-in -73.62, 146.77 APE8-rot-in 269.24 APE67-dihe-in -62.21, -20.07 -114.53, 6.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.551 D176A,F327S None None XRAY 1.86 0.25 0.277 X 367.0 326.0 23 25 11 14 [[24, 308]] 1.0 2fsm Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2NPQA Q16539 4 351 360.0 No_ligand No_ligand Inactive DFGout 14.6321 11.1923 None -103.61, 152.87 -73.15, -38.43 25.92, 999.0 250.29, 79.85 999.0, 999.0 in-in in 9.3978 Saltbr-in 2.5064 HRD-in -66.51, -57.37 82.83, -12.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.57 APE8-dihe-in -64.2, 131.82 APE8-rot-in 297.33 APE67-dihe-in -66.2, -17.35 -108.62, 11.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1092 None None None XRAY 1.8 0.205 0.245 A 367.0 326.0 22 25 11 14 [[24, 308]] 1.0 2npq Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.3e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4GEOA Q16539 5 351 360.0 No_ligand No_ligand Inactive DFGout 14.6982 10.4768 None -99.3, 157.78 -78.87, -32.72 -149.84, 149.23 159.18, 69.75 -8.29, -58.01 in-in in 9.1001 Saltbr-in 2.7027 HRD-in -70.09, -53.53 83.75, -23.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.49 APE8-rot-in 284.08 APE67-dihe-in -65.9, -24.46 -115.44, 16.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 M194A,L195A,H228A,I229A,Y258A None None XRAY 1.66 0.22 0.255 A 367.0 326.0 21 25 13 12 [[24, 308]] 1.0 4geo Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.5e-82 283.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MH3A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGout 16.0117 12.2636 None -114.58, 161.92 -64.07, -39.51 -151.45, 141.52 204.42, 94.84 -53.7, 163.27 in-in in 9.4164 Saltbr-in 3.1177 HRD-in -69.93, -57.84 85.51, -16.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 118.94 APE8-dihe-out -52.23, -52.04 APE8-rot-in 279.55 APE67-dihe-in -63.03, -30.03 -48.23, -28.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9258 F169R None None XRAY 2.2 0.237 0.293 A 360.0 334.0 14 25 13 12 [[24, 308]] 1.0 3mh3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-83 286.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3MH1A Q16539 5 352 360.0 No_ligand No_ligand Inactive DFGout 11.3758 12.2353 None -99.26, 148.49 -61.18, -25.87 178.03, 164.96 999.0, 999.0 -59.73, 139.02 in-out in 9.9586 Saltbr-out 4.5054 HRD-in -75.25, -51.25 81.19, -13.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 77.57 APE9-dihe-na -67.78, 125.39 APE8-dihe-out -45.69, -42.63 APE8-rot-in 281.79 APE67-dihe-in -67.4, -30.68 -52.54, -31.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.1691 APE9-dist-out 11.0133 F169G None None XRAY 2.2 0.235 0.296 A 360.0 337.0 11 25 14 11 [[24, 308]] 1.0 3mh1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3IW5A Q16539 4 353 360.0 DF3:362 Type1 Inactive DFGout 11.1509 13.9047 None -114.26, 151.74 -75.63, -51.5 -142.13, 148.75 301.54, 111.74 -97.74, -179.21 in-out in 9.3566 Saltbr-out 3.7762 HRD-in -63.07, -54.05 82.88, -17.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.82 APE8-dihe-out -73.02, -0.44 APE8-rot-out 77.62 APE67-dihe-in -71.77, -14.42 -134.76, 1.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0117 C119S,C162S,A172C,F327L None None XRAY 2.5 0.211 0.291 A 360.0 336.0 14 25 13 12 [[24, 308]] 1.0 3iw5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3L8SA Q16539 4 353 360.0 BFF:361 Type1 Inactive DFGout 15.4888 11.9771 None -119.54, 162.4 -99.13, -16.66 31.92, 999.0 247.73, 144.9 999.0, 999.0 in-in in 9.4966 Saltbr-in 2.8175 HRD-in -77.51, -50.13 90.87, -25.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 107.11 APE9-dihe-na -94.83, 118.78 APE8-dihe-out -62.16, -3.07 APE8-rot-out 173.18 APE67-dihe-in -59.13, -22.21 -95.45, -15.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2005 C119S,C162S,A172C,F327L None None XRAY 2.35 0.242 0.307 A 360.0 334.0 16 25 12 13 [[24, 308]] 1.0 3l8s Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6SFKA Q16539 4 353 360.0 LB8:405 Type2 Inactive DFGout 16.1397 8.661 None -134.22, 179.77 -135.11, 110.79 -76.65, -37.33 179.52, 81.34 91.97, 27.2 in-in in 8.862 Saltbr-in 2.7388 HRD-in -69.84, -54.1 78.48, -10.85 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 115.89 APE9-dihe-na -95.71, 136.28 APE8-dihe-out -55.44, -40.63 APE8-rot-in 282.06 APE67-dihe-in -62.97, -23.38 -59.23, -26.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.5712 APE9-dist-out 11.0508 None None None XRAY 1.8 0.182 0.218 A 361.0 339.0 11 25 14 11 [[24, 308]] 1.0 6sfk Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3HECA Q16539 5 352 360.0 STI:1 Type2 Inactive DFGout 15.7975 11.0354 None -130.2, -167.81 -152.58, 126.29 -77.67, 999.0 267.8, 49.04 999.0, 999.0 in-in in 8.8977 Saltbr-in 3.2136 HRD-in -65.98, -59.44 85.44, -17.29 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.24 APE8-dihe-out -59.5, -40.66 APE8-rot-in 292.4 APE67-dihe-in -54.55, -30.33 -64.97, -31.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9353 None None None XRAY 2.5 0.222 0.3 A 348.0 329.0 19 25 11 14 [[24, 308]] 1.0 3hec Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.2e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3NNUA Q16539 5 352 360.0 EDB:355 Type2 Inactive DFGout 14.4851 8.1772 None -144.19, -179.5 -134.33, 110.12 -98.4, 16.73 217.88, 127.0 -68.22, 116.23 in-in in 8.6063 Saltbr-in 2.743 HRD-in -68.9, -52.98 78.42, -18.23 in-out-out SNCioo out-out ActLoopNT-out 16.2443 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.69, 129.02 APE9-dihe-na -61.08, -14.62 APE8-dihe-out -64.78, -22.47 APE8-rot-out 54.7 APE67-dihe-in -66.31, -27.81 -111.35, -16.11 APE12-dist-out 19.9681 APE11-dist-out 21.0071 APE10-dist-out 15.5576 APE9-dist-out 11.7319 None None None XRAY 2.4 0.18 0.227 A 354.0 348.0 0 25 25 0 [[24, 308]] 1.0 3nnu Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3NNWA Q16539 4 352 360.0 EDD:355 Type2 Inactive DFGout 14.3784 8.6643 None -143.48, -174.31 -141.84, 103.66 -83.23, 17.1 235.42, 130.16 -65.05, 104.27 in-in in 8.6157 Saltbr-in 2.7512 HRD-in -70.41, -54.26 74.72, -13.01 in-out-out SNCioo out-out ActLoopNT-out 15.4752 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.01, 133.74 APE9-dihe-na -64.57, -21.86 APE8-dihe-out -56.02, -24.79 APE8-rot-out 60.58 APE67-dihe-in -62.38, -23.64 -112.3, -18.98 APE12-dist-out 19.8482 APE11-dist-out 21.0813 APE10-dist-out 15.5234 APE9-dist-out 11.7945 None None None XRAY 1.89 0.169 0.213 A 354.0 349.0 0 25 25 0 [[24, 308]] 1.0 3nnw Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1KV2A Q16539 5 352 360.0 B96:391 Type2 Inactive DFGout 14.8152 8.959 None -153.25, -166.57 -152.53, 103.77 -62.95, 999.0 246.86, 90.74 999.0, 999.0 in-in in 8.3523 Saltbr-in 2.8201 HRD-in -55.42, -53.31 70.34, -10.39 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -176.94 APE8-rot-in 323.3 APE67-dihe-in -39.27, -35.13 -88.76, -27.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.245 0.318 A 360.0 325.0 23 25 10 15 [[24, 308]] 1.0 1kv2 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WBSA Q16539 4 355 360.0 LI2:1355 Type2 Inactive DFGout 16.3682 9.1383 None -141.08, -171.86 -138.43, 108.84 -92.64, 15.84 205.17, 157.01 -67.74, 124.28 in-in in 9.2788 Saltbr-in 2.5239 HRD-in -71.99, -54.5 76.21, -17.47 in-out-out SNCioo out-out ActLoopNT-out 15.9192 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -136.45, 131.33 APE9-dihe-na -56.06, -21.39 APE8-dihe-out -50.15, -30.91 APE8-rot-in 286.61 APE67-dihe-in -68.26, -21.94 -116.21, -13.19 APE12-dist-out 19.6491 APE11-dist-out 20.954 APE10-dist-out 15.3525 APE9-dist-out 11.6531 None None None XRAY 1.8 0.194 0.234 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbs Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1WBTA Q16539 4 355 360.0 WBT:1355 Type2 Inactive DFGout 16.1777 9.3066 None -136.66, -169.87 -139.17, 111.94 -100.88, 32.0 201.3, 163.54 -84.42, 113.54 in-in in 9.3551 Saltbr-in 2.4938 HRD-in -72.43, -50.88 71.17, -6.74 in-out-out SNCioo out-out ActLoopNT-out 15.5573 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.15, 129.11 APE9-dihe-na -47.04, -21.32 APE8-dihe-out -62.22, -29.71 APE8-rot-in 301.06 APE67-dihe-in -64.82, -23.13 -111.68, -14.87 APE12-dist-out 19.9272 APE11-dist-out 21.1303 APE10-dist-out 15.5234 APE9-dist-out 11.7791 None None None XRAY 2.0 0.229 0.276 A 360.0 352.0 0 25 25 0 [[24, 308]] 1.0 1wbt Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9CJ1A Q16539 5 351 360.0 NIL:402 Type2 Inactive DFGout 16.6719 8.5784 None -136.39, -179.16 -135.71, 113.19 -111.0, 999.0 189.38, 176.24 999.0, 999.0 in-in in 9.1741 Saltbr-in 2.8091 HRD-in -73.57, -53.73 76.57, -11.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -113.61, 109.02 APE9-dihe-na -78.59, 135.32 APE8-dihe-out -60.73, -32.98 APE8-rot-out 68.81 APE67-dihe-in -60.63, -23.89 -58.26, -32.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8548 None TPO180,PTR182 TPO180,PTR182 XRAY 1.8 0.188 0.232 A 360.0 331.0 16 25 13 12 [[24, 308]] 1.0 9cj1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3UVRA Q16539 5 351 360.0 06F:361 Type2 Inactive DFGout 15.5607 8.5245 None -148.63, 178.6 -133.58, 101.18 -90.01, -1.78 195.55, 17.77 -54.07, 127.45 in-in in 8.2112 Saltbr-in 2.6266 HRD-in -62.71, -55.49 83.79, -17.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.89 APE8-dihe-out -51.15, -30.26 APE8-rot-in 300.71 APE67-dihe-in -70.54, -25.21 -93.95, -15.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6213 None None None XRAY 2.1 0.204 0.245 A 360.0 331.0 16 25 13 12 [[24, 308]] 1.0 3uvr Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4L8MA Q16539 5 352 360.0 F46:403 Type2 Inactive DFGout 13.9994 6.7696 None -110.2, 165.17 -109.72, -18.28 -95.65, 105.75 169.67, 89.03 -90.5, 163.87 in-in in 8.7719 Saltbr-in 2.7377 HRD-in -71.75, -54.71 80.79, -19.29 in-out-out SNCioo out-out ActLoopNT-out 21.5079 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 46.18 APE9-dihe-na -164.48, 135.91 APE8-dihe-out -83.96, -31.73 APE8-rot-out 69.65 APE67-dihe-in -61.38, -25.8 -64.67, -22.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.5717 APE9-dist-out 12.2154 None None None XRAY 2.1 0.229 0.279 A 360.0 339.0 9 25 18 7 [[24, 308]] 1.0 4l8m Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3BV3A Q16539 5 352 360.0 P39:501 Type2 Inactive DFGout 11.358 12.0794 None -135.58, -173.61 -142.65, 155.76 58.91, 28.17 314.53, 124.45 -62.18, 128.85 in-in in 9.3695 Saltbr-in 2.8364 HRD-in -71.41, -56.4 68.14, 1.58 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -87.73, 112.95 APE9-dihe-na -70.98, 129.85 APE8-dihe-out -68.68, -24.27 APE8-rot-out 135.98 APE67-dihe-in -59.57, -28.6 -57.65, -28.26 APE12-dist-none 999.0 APE11-dist-in 12.4854 APE10-dist-out 10.977 APE9-dist-out 10.8636 None None None XRAY 2.59 0.198 0.284 A 366.0 338.0 10 25 15 10 [[24, 308]] 1.0 3bv3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2YISA Q16539 5 353 360.0 YIS:1353,I46:1354 Type2,Allosteric Inactive DFGout 15.833 8.5763 None -138.39, -175.22 -139.39, 106.04 -86.53, 999.0 192.46, 60.65 999.0, 999.0 in-in in 8.5948 Saltbr-in 2.6488 HRD-in -65.43, -49.96 74.88, -12.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -110.86, 112.45 APE9-dihe-na -50.05, 127.69 APE8-dihe-out -57.83, -43.06 APE8-rot-in 274.36 APE67-dihe-in -59.28, -29.93 -54.84, -31.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1314 None None None XRAY 2.0 0.216 0.255 A 359.0 326.0 23 25 13 12 [[24, 308]] 1.0 2yis Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2YIWA Q16539 5 353 360.0 YIW:1353,I46:1354 Type2,Allosteric Inactive DFGout 15.1257 8.2719 None -141.89, -172.05 -138.89, 100.26 -82.98, 999.0 217.28, 137.57 999.0, 999.0 in-in in 8.5919 Saltbr-in 2.7683 HRD-in -71.94, -52.53 77.45, -13.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -110.91, 126.0 APE9-dihe-na -61.22, 128.26 APE8-dihe-out -61.06, -42.06 APE8-rot-in 267.54 APE67-dihe-in -58.91, -30.27 -58.86, -25.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.076 None None None XRAY 2.0 0.223 0.259 A 359.0 326.0 23 25 13 12 [[24, 308]] 1.0 2yiw Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.8e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9CJ5A Q16539 5 352 360.0 A1AWV:404,PDO:405 Type2,Allosteric Inactive DFGout 15.6037 9.9462 None -161.07, 167.42 -158.02, 105.92 -133.23, 63.25 67.22, 124.33 -54.97, -26.0 in-in in 8.6967 Saltbr-in 2.7666 HRD-in -81.64, -51.08 76.49, -58.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -113.44, 119.12 APE9-dihe-na -66.71, 142.75 APE8-dihe-out -74.59, -35.87 APE8-rot-in 303.87 APE67-dihe-in -57.3, -25.76 -59.56, -25.3 APE12-dist-none 999.0 APE11-dist-out 14.2449 APE10-dist-out 15.0331 APE9-dist-out 11.8063 None None None XRAY 3.3 0.247 0.276 A 360.0 334.0 11 25 19 6 [[24, 308]] 1.0 9cj5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3K3JA Q16539 5 352 360.0 F4C:361,I46:362 Type2,Allosteric Inactive DFGout 14.065 10.2016 None -131.58, -161.61 -147.02, 101.88 -61.41, 999.0 271.38, 120.65 999.0, 999.0 in-in in 9.5761 Saltbr-in 3.4443 HRD-in -69.65, -53.93 78.02, -14.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 102.6 APE9-dihe-na -77.21, 127.93 APE8-dihe-out -43.12, -42.69 APE8-rot-in 284.51 APE67-dihe-in -68.28, -22.44 -62.73, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0063 None None None XRAY 1.995 0.196 0.245 A 362.0 329.0 19 25 12 13 [[24, 308]] 1.0 3k3j Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LFDA Q16539 4 353 360.0 Z85:361 Type3 Inactive DFGout 14.3999 11.1853 None -141.36, 173.62 -120.67, -179.03 -146.09, 999.0 271.75, 117.44 999.0, 999.0 in-in in 8.8537 Saltbr-in 3.2321 HRD-in -64.3, -44.5 70.71, -12.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.22 APE8-dihe-out -67.22, -56.7 APE8-rot-in 307.71 APE67-dihe-in -57.89, -22.29 -55.8, -7.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0271 C119S,C162S,A172C,F327L None None XRAY 3.4 0.23 0.305 A 360.0 331.0 19 25 11 14 [[24, 308]] 1.0 3lfd Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 1KV1A Q16539 5 352 360.0 BMU:391 Type3 Inactive DFGout 13.6352 9.5564 None -159.24, -177.02 -146.07, 100.83 -75.42, -134.45 282.12, 117.71 154.13, 999.0 in-in in 9.1633 Saltbr-in 3.578 HRD-in -68.61, -47.67 58.19, -2.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.94 APE8-dihe-out -125.34, -40.47 APE8-rot-in 276.42 APE67-dihe-in -57.32, -20.72 -62.12, -27.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2711 None None None XRAY 2.5 0.24 0.284 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 1kv1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3O8TA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.2632 10.3257 None -137.91, -177.55 -138.77, 94.77 -70.74, -1.41 999.0, 999.0 121.86, 999.0 in-out in 9.427 Saltbr-out 4.2701 HRD-in -65.83, -55.54 74.19, -14.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 158.65 APE8-dihe-out -42.15, -37.49 APE8-rot-out 44.7 APE67-dihe-in -68.78, -13.14 -104.02, 1.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.491 F169A None None XRAY 2.0 0.229 0.282 A 360.0 332.0 16 25 12 13 [[24, 308]] 1.0 3o8t Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3OC1A Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 12.7295 11.1023 None -150.55, -172.96 -134.29, 139.02 -118.77, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.4178 Saltbr-in 3.3368 HRD-in -75.41, -45.78 70.08, -9.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.76 APE8-dihe-out -49.39, -49.27 APE8-rot-in 287.36 APE67-dihe-in -53.47, -28.65 -54.1, -35.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0942 F169G None None XRAY 2.59 0.229 0.303 A 360.0 330.0 18 25 11 14 [[24, 308]] 1.0 3oc1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 3e-83 285.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4E8AA Q16539 4 351 360.0 0OA:500 Allosteric Inactive None 999.0 999.0 None -92.32, 155.4 -102.08, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.1175 Saltbr-in 2.7168 HRD-in -65.57, -46.59 81.57, -30.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.55 APE8-rot-out 176.26 APE67-dihe-in -54.8, -25.07 -111.54, 8.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.225 0.313 A 360.0 327.0 21 25 9 16 [[24, 308]] 1.0 4e8a Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5N63A Q16539 5 353 360.0 8OW:401 Allosteric Inactive None 999.0 999.0 None -111.61, 156.37 57.89, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.4088 Saltbr-in 3.3497 HRD-in -72.45, -51.89 81.55, -15.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.74 APE8-dihe-out -67.87, -33.77 APE8-rot-in 320.31 APE67-dihe-in -67.35, -20.52 -64.07, -21.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9673 None None None XRAY 2.4 0.196 0.228 A 360.0 325.0 24 25 10 15 [[24, 308]] 1.0 5n63 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5O8UA Q16539 5 352 360.0 9O5:401 Allosteric Inactive None 999.0 999.0 None -101.85, 161.09 6.94, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2542 Saltbr-in 3.5355 HRD-in -71.17, -53.83 80.39, -15.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -95.46, 98.26 APE9-dihe-na -67.91, 134.4 APE8-dihe-out -58.48, -41.37 APE8-rot-in 290.06 APE67-dihe-in -68.7, -21.24 -53.34, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0062 S252C None None XRAY 2.0 0.205 0.252 A 360.0 331.0 17 25 12 13 [[24, 308]] 1.0 5o8u Homo sapiens CMGC_MAPK14_HUMAN CMGC 2e-84 289.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5O8VA Q16539 5 354 360.0 9O2:401 Allosteric Inactive None 999.0 999.0 None -135.74, -173.21 -149.06, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.3143 Saltbr-in 3.2058 HRD-in -73.19, -53.88 74.63, -13.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 115.51 APE9-dihe-na -74.16, 127.19 APE8-dihe-out -51.78, -36.7 APE8-rot-in 274.38 APE67-dihe-in -62.01, -28.06 -62.61, -31.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2012 S251C None None XRAY 2.0 0.209 0.269 A 360.0 328.0 22 25 11 14 [[24, 308]] 1.0 5o8v Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5N65A Q16539 5 352 360.0 8OT:401,8OT:402 Allosteric,Type1 Inactive None 999.0 999.0 None -100.31, 170.51 -89.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.0828 Saltbr-in 2.5351 HRD-in -71.85, -53.72 79.7, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.76 APE8-dihe-out -69.0, -27.21 APE8-rot-out 184.87 APE67-dihe-in -59.8, -25.07 -68.54, -20.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5068 None None None XRAY 2.0 0.193 0.216 A 360.0 333.0 15 25 10 15 [[24, 308]] 1.0 5n65 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4DLJA Q16539 4 354 360.0 6RG:401,6RG:402 Allosteric,Type1 Inactive None 999.0 999.0 None -99.65, 167.18 -71.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2807 Saltbr-in 2.8622 HRD-in -65.2, -60.52 84.01, -15.15 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 99.76 APE9-dihe-na -61.5, 134.32 APE8-dihe-out -51.58, -38.85 APE8-rot-in 307.02 APE67-dihe-in -49.07, -29.87 -61.38, -36.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2245 None None None XRAY 2.6 0.216 0.314 A 360.0 336.0 15 25 11 14 [[24, 308]] 1.0 4dlj Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH5A Q16539 4 354 360.0 IRG:401,0OM:402 Allosteric,Type1 Inactive None 999.0 999.0 None -108.39, 163.33 57.95, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.3088 Saltbr-in 2.9014 HRD-in -72.32, -49.67 77.23, -19.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.62 APE8-dihe-out -54.92, -38.6 APE8-rot-in 283.85 APE67-dihe-in -62.06, -24.82 -60.96, -29.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.251 None None None XRAY 2.0 0.232 0.285 A 360.0 329.0 22 25 10 15 [[24, 308]] 1.0 4eh5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH6A Q16539 4 354 360.0 IRG:401,0ON:402 Allosteric,Type1 Inactive None 999.0 999.0 None -123.46, -172.29 -120.99, 34.21 -158.17, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.1714 Saltbr-in 2.742 HRD-in -69.9, -51.68 78.55, -21.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.55 APE8-dihe-out -58.14, -38.92 APE8-rot-in 265.12 APE67-dihe-in -64.71, -26.03 -57.04, -28.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2302 None None None XRAY 2.1 0.227 0.277 A 360.0 335.0 16 25 11 14 [[24, 308]] 1.0 4eh6 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH7A Q16539 4 354 360.0 IRG:401,0OO:402 Allosteric,Type1 Inactive None 999.0 999.0 None -98.76, 137.9 -63.12, -45.22 -156.84, 139.66 999.0, 999.0 98.21, 999.0 in-in in 9.2463 Saltbr-in 3.0514 HRD-in -69.27, -51.42 76.94, -19.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 98.3 APE9-dihe-na -75.8, 145.15 APE8-dihe-out -61.37, -38.48 APE8-rot-in 268.7 APE67-dihe-in -62.89, -26.04 -57.18, -28.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3386 None None None XRAY 2.1 0.224 0.265 A 360.0 337.0 14 25 13 12 [[24, 308]] 1.0 4eh7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6QYXA Q16539 4 352 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -106.52, 118.78 -115.56, -98.31 -61.04, -63.53 344.48, 91.73 -150.21, 9.86 in-in in 9.3265 Saltbr-in 2.5795 HRD-in -73.9, -51.98 75.86, -12.54 in-out-out SNCioo out-out ActLoopNT-out 31.6763 ActLoopCT-out nonTYR APEdihe_aaono APEdist_iioo APE10-dihe-na -74.45, -19.47 APE9-dihe-na -64.45, -33.91 APE8-dihe-out 125.2, -117.03 APE8-rot-none 999.0 APE67-dihe-out -129.02, 137.69 -169.25, 130.59 APE12-dist-in 10.8064 APE11-dist-in 13.2469 APE10-dist-out 16.7923 APE9-dist-out 16.8226 None None None XRAY 1.66 0.188 0.242 A 366.0 319.0 10 31 21 10 [[24, 308]] 1.0 6qyx Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.4e-85 290.6 1.0 301.0 301.0 12 13 14 16 18 53 71 75 147 149 148 150.0 205 43 38 37 36 35 34 33 32 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2FSTX Q16539 5 352 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -108.93, 154.69 31.88, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2643 Saltbr-in 2.5805 HRD-in -69.82, -57.76 81.6, -6.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.42 APE8-dihe-in -75.33, 147.85 APE8-rot-in 261.2 APE67-dihe-in -65.73, -20.85 -104.84, 3.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4092 D176A,F327L None None XRAY 1.45 0.236 0.241 X 367.0 324.0 24 25 10 15 [[24, 308]] 1.0 2fst Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2FSLX Q16539 4 354 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -101.98, 152.79 -34.78, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.8787 Saltbr-in 2.8168 HRD-in -71.36, -53.06 78.29, -10.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 132.09 APE9-dihe-na -72.48, 120.99 APE8-dihe-in -73.0, 149.08 APE8-rot-in 253.17 APE67-dihe-in -61.11, -23.64 -104.43, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.452 D176A,F327S None None XRAY 1.7 0.244 0.24 X 367.0 332.0 19 25 11 14 [[24, 308]] 1.0 2fsl Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 2FSOX Q16539 5 353 360.0 No_ligand No_ligand Inactive None 999.0 999.0 None -106.29, 157.33 52.19, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.1823 Saltbr-in 2.5529 HRD-in -65.61, -56.88 80.27, -8.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 5.77 APE8-dihe-in -71.46, 138.27 APE8-rot-in 251.69 APE67-dihe-in -62.5, -22.21 -97.22, 4.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4272 D176A None None XRAY 1.83 0.178 0.224 X 367.0 325.0 24 25 10 15 [[24, 308]] 1.0 2fso Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.6e-85 290.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 6M95A Q16539 5 352 360.0 J8S:501 Type1 Inactive None 999.0 999.0 None -97.09, 121.22 -100.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2123 Saltbr-in 2.8615 HRD-in -65.02, -59.89 79.82, -9.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 158.99 APE8-dihe-out -59.43, -17.68 APE8-rot-out 85.56 APE67-dihe-in -68.8, -17.32 -105.14, -3.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0601 None None None XRAY 1.8 0.174 0.208 A 388.0 333.0 15 25 10 15 [[24, 308]] 1.0 6m95 Homo sapiens CMGC_MAPK14_HUMAN CMGC 1e-84 290.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 9YLHA Q16539 5 353 360.0 A1CX9:503 Type1 Inactive None 999.0 999.0 None -96.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.4002 Saltbr-in 2.8479 HRD-in -68.57, -49.88 76.6, -12.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -111.85, 121.68 APE9-dihe-na -60.7, -56.76 APE8-dihe-in -129.2, 132.37 APE8-rot-in 311.57 APE67-dihe-out -68.41, -9.84 -103.78, 107.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3844 None TPO180 CME162,TPO180 XRAY 2.02 0.213 0.239 A 360.0 339.0 10 25 15 10 [[24, 308]] 1.0 9ylh Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3LFAA Q16539 4 353 360.0 1N1:361 Type1 Inactive None 999.0 999.0 None -119.32, 169.35 -154.54, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2412 Saltbr-in 2.7349 HRD-in -67.55, -57.07 85.83, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.05 APE8-dihe-out -85.63, -3.59 APE8-rot-in 346.34 APE67-dihe-in -59.81, -27.96 -94.61, -12.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8947 None None None XRAY 2.1 0.204 0.254 A 360.0 333.0 17 25 10 15 [[24, 308]] 1.0 3lfa Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 3ZSHA Q16539 4 352 360.0 469:400 Type1 Inactive None 999.0 999.0 None -106.18, 148.72 85.75, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.0607 Saltbr-in 3.2922 HRD-in -65.73, -56.19 85.19, -16.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -63.62 APE8-dihe-out -49.73, -55.3 APE8-rot-out 72.73 APE67-dihe-in -63.94, -22.31 -77.97, -13.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0841 None None None XRAY 2.05 0.208 0.255 A 362.0 331.0 15 25 10 15 [[24, 308]] 1.0 3zsh Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 8A8MA Q16539 5 353 360.0 AP2:60900 Type1 Inactive None 11.0583 18.3662 None -133.1, -179.58 58.18, 65.77 -88.58, 125.42 201.03, 134.23 104.29, 124.16 in-out in 8.1966 Saltbr-out 9.5148 HRD-in -64.82, -44.91 64.86, -2.06 out-out-out SNCooo out-out ActLoopNT-out 6.9629 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -131.1, 94.25 APE9-dihe-na -165.78, 126.4 APE8-dihe-in -95.27, 137.04 APE8-rot-out 60.89 APE67-dihe-out 70.19, 13.63 -115.98, -56.13 APE12-dist-out 23.1068 APE11-dist-out 21.7967 APE10-dist-out 23.4916 APE9-dist-out 14.1872 T180V None None EM 4.0 999.0 999.0 A 381.0 349.0 0 25 25 0 [[24, 308]] 1.0 8a8m Homo sapiens CMGC_MAPK14_HUMAN CMGC 4e-84 288.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 4EH3A Q16539 4 354 360.0 NAR:401,IRG:402 Type1,Allosteric Inactive None 999.0 999.0 None -93.8, 152.76 -77.66, -36.64 -150.96, 113.75 999.0, 999.0 -75.95, -166.36 in-out in 9.6206 Saltbr-out 4.0293 HRD-in -80.03, -53.65 83.21, -19.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.56 APE9-dihe-na -87.37, 152.3 APE8-dihe-out -66.91, -31.74 APE8-rot-in 263.06 APE67-dihe-in -67.51, -22.33 -71.06, -17.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.9391 APE9-dist-out 11.2796 None None None XRAY 2.4 0.219 0.277 A 360.0 339.0 12 25 15 10 [[24, 308]] 1.0 4eh3 Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 8VXEA Q16539 6 352 360.0 A1AD9:401,A1AD9:402 Type1,Allosteric Inactive None 999.0 999.0 None -98.19, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.005 Saltbr-in 2.6416 HRD-in -65.83, -53.75 77.17, -14.66 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 98.85 APE9-dihe-na -79.04, 136.28 APE8-dihe-out -61.75, -41.07 APE8-rot-in 303.56 APE67-dihe-in -62.53, -24.73 -58.42, -26.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6338 None None None XRAY 1.85 0.223 0.289 A 387.0 329.0 18 25 10 15 [[24, 308]] 1.0 8vxe Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.5e-85 290.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_HUMAN 5OMHA Q16539 5 353 360.0 9Y5:401 Type1.5_Back Inactive None 999.0 999.0 None -133.9, 160.5 -99.84, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.5724 Saltbr-out 3.8741 HRD-in -69.09, -50.51 81.58, -12.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.3 APE8-dihe-out -74.47, -33.47 APE8-rot-out 59.61 APE67-dihe-in -59.66, -23.0 -57.69, -25.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9517 None None None XRAY 2.5 0.218 0.277 A 360.0 325.0 24 25 10 15 [[24, 308]] 1.0 5omh Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZE P47811 4 353 360.0 AGS:60401 ATPlike Active DFGin 6.5145 14.9809 BLAminus -122.06, 164.78 72.33, 78.3 -82.97, 27.83 284.83, 92.09 -68.73, -16.77 in-in in 9.4753 Saltbr-in 3.5664 HRD-in -92.47, -52.47 76.16, -3.26 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.62, 176.88 APE9-dihe-na 58.43, 166.45 APE8-dihe-in -84.96, 144.19 APE8-rot-in 316.3 APE67-dihe-in -61.16, -25.49 -55.46, -53.03 APE12-dist-in 11.933 APE11-dist-in 11.3947 APE10-dist-in 7.2363 APE9-dist-in 3.1259 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 E 360.0 345.0 5 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZF P47811 5 353 360.0 AGS:60401 ATPlike Active DFGin 6.5814 14.7457 BLAminus -104.46, 169.41 67.42, 93.44 -106.87, 21.93 284.61, 82.38 -60.31, -14.32 in-in in 9.3181 Saltbr-in 2.6918 HRD-in -84.83, -58.57 70.0, 21.45 in-in-in SNCiii in-in ActLoopNT-in 3.0664 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.79, 145.31 APE9-dihe-na 83.88, 162.38 APE8-dihe-in -79.27, 130.51 APE8-rot-in 303.15 APE67-dihe-in -54.1, -23.47 -46.06, -59.5 APE12-dist-in 11.9255 APE11-dist-in 11.5323 APE10-dist-in 7.2453 APE9-dist-in 3.3341 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 F 360.0 343.0 6 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7PVUA P47811 5 353 360.0 No_ligand No_ligand Inactive DFGin 5.6168 15.1593 ABAminus -94.57, -36.92 -122.93, 174.85 -130.26, 15.13 303.73, 103.6 73.11, 17.43 out-out out 10.5221 Saltbr-out 5.0442 HRD-in -76.13, -63.33 89.97, -15.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -64.18 APE8-dihe-in -149.52, 134.03 APE8-rot-out 185.0 APE67-dihe-in -66.63, -19.36 -112.0, 8.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8989 None None None XRAY 2.154 0.207 0.239 A 359.0 337.0 12 25 13 12 [[24, 308]] 1.0 7pvu Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZG P47811 5 353 360.0 AGS:60500 ATPlike Inactive DFGin 6.7542 14.7083 BLAminus -116.89, 166.61 73.83, 77.69 -92.77, 19.2 291.57, 84.89 -50.42, -23.42 in-out in 9.7677 Saltbr-out 3.6394 HRD-in -81.86, -61.67 80.49, 3.8 out-in-in SNCoii in-in ActLoopNT-in 3.0358 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.71, 150.03 APE9-dihe-na 72.19, 148.63 APE8-dihe-in -60.61, 140.23 APE8-rot-in 308.55 APE67-dihe-in -63.92, -23.58 -59.84, -44.11 APE12-dist-in 11.9561 APE11-dist-in 11.829 APE10-dist-in 7.4102 APE9-dist-in 3.3534 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 G 360.0 344.0 5 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2OZAB P47811 6 353 360.0 No_ligand No_ligand Inactive DFGin 7.7822 16.0068 BLAminus -118.23, 171.93 54.76, 85.27 -98.04, -31.59 288.8, 55.22 -31.15, 9.05 out-out out 11.0093 Saltbr-out 5.161 HRD-in -57.49, -58.06 98.2, -27.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -133.01, 138.56 APE9-dihe-na -87.21, -22.73 APE8-dihe-in -156.9, 157.2 APE8-rot-out 72.26 APE67-dihe-in -61.42, -8.66 -124.37, 38.47 APE12-dist-in 9.3621 APE11-dist-in 12.6039 APE10-dist-out 10.1881 APE9-dist-out 12.9814 None None None XRAY 2.7 0.239 0.296 B 366.0 340.0 8 25 17 8 [[24, 308]] 1.0 2oza Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3PY3A P47811 1 354 360.0 No_ligand No_ligand Inactive DFGin 6.7741 16.154 BLAminus -107.18, 162.59 73.02, 100.48 -107.92, 21.45 284.78, 77.62 -59.69, -38.19 out-out out 11.3048 Saltbr-out 5.3477 HRD-in -69.48, -46.17 76.52, -12.87 out-in-out SNCoio in-out ActLoopNT-in 2.7663 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -83.88, 106.41 APE9-dihe-na -79.77, -18.34 APE8-dihe-in -66.16, 122.11 APE8-rot-in 299.66 APE67-dihe-in -70.9, -29.93 -90.94, -45.01 APE12-dist-out 6.6053 APE11-dist-in 9.0286 APE10-dist-in 6.8328 APE9-dist-out 8.1216 None TPO180,PTR182 TPO180,PTR182 XRAY 2.1 0.215 0.24 A 380.0 354.0 0 25 25 0 [[24, 308]] 1.0 3py3 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4TYHB P47811 6 353 360.0 39G:401 Type1.5_Back Inactive DFGin 7.39 16.0222 BLAminus -100.73, 158.14 81.52, 87.17 -105.84, 20.18 292.32, 72.56 -57.61, -46.84 out-out out 10.7337 Saltbr-out 5.5492 HRD-in -67.8, -42.55 76.87, -55.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -132.03, 125.28 APE9-dihe-na -64.76, -61.75 APE8-dihe-in -121.75, 174.44 APE8-rot-out 56.39 APE67-dihe-out -76.5, -21.76 -153.78, 65.22 APE12-dist-in 10.0478 APE11-dist-in 12.7972 APE10-dist-out 9.8392 APE9-dist-out 12.8344 None None None XRAY 3.0 0.232 0.313 B 348.0 335.0 13 25 17 8 [[24, 308]] 1.0 4tyh Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8VA P47811 5 352 360.0 SLV:401 Allosteric Inactive DFGin 7.6242 17.1526 BLBminus -126.3, 168.82 56.55, 59.16 -55.68, 146.02 284.01, 72.07 -69.49, 121.4 in-in in 9.8917 Saltbr-in 2.7978 HRD-in -67.25, -52.7 83.66, -13.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.92, 131.25 APE9-dihe-na -62.03, -18.21 APE8-dihe-out -61.99, -18.31 APE8-rot-out 54.16 APE67-dihe-in -64.25, -20.09 -113.24, -17.54 APE12-dist-out 21.8414 APE11-dist-out 24.0264 APE10-dist-out 18.3188 APE9-dist-out 11.8622 None None None XRAY 1.479 0.18 0.195 A 360.0 347.0 1 25 24 1 [[24, 308]] 1.0 5r8v Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8WA P47811 5 352 360.0 JND:401 Allosteric Inactive DFGin 7.6227 17.1396 BLBminus -134.39, -175.76 54.2, 58.03 -54.53, 148.27 282.17, 71.55 -69.56, 120.12 in-in in 9.786 Saltbr-in 2.7971 HRD-in -69.08, -52.16 84.44, -11.95 in-out-out SNCioo out-out ActLoopNT-out 10.527 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.15, 133.86 APE9-dihe-na -63.5, -21.8 APE8-dihe-out -56.73, -22.52 APE8-rot-out 52.13 APE67-dihe-in -65.69, -17.77 -112.94, -20.97 APE12-dist-out 21.8759 APE11-dist-out 24.1357 APE10-dist-out 18.3954 APE9-dist-out 11.8458 None None None XRAY 1.5 0.186 0.201 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r8w Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8XA P47811 5 352 360.0 SLY:401 Allosteric Inactive DFGin 7.7606 16.9981 BLBminus -136.1, -175.23 50.71, 58.98 -55.89, 147.73 286.33, 69.34 -66.18, 109.61 in-in in 9.6118 Saltbr-in 2.9715 HRD-in -65.45, -55.16 83.61, -13.56 in-out-out SNCioo out-out ActLoopNT-out 11.133 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.33, 135.56 APE9-dihe-na -62.93, -23.96 APE8-dihe-out -59.18, -23.72 APE8-rot-out 54.02 APE67-dihe-in -65.06, -22.4 -109.5, -17.51 APE12-dist-out 22.3746 APE11-dist-out 24.4521 APE10-dist-out 18.6895 APE9-dist-out 11.7277 None None None XRAY 1.73 0.221 0.249 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r8x Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R93A P47811 4 352 360.0 SOJ:401 Allosteric Inactive DFGin 7.6364 17.141 BLBminus -125.0, 173.15 52.85, 61.08 -58.46, 147.19 282.32, 72.46 -70.36, 117.48 in-in in 9.7995 Saltbr-in 2.729 HRD-in -68.86, -51.59 81.16, -8.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.22, 132.58 APE9-dihe-na -63.34, -21.4 APE8-dihe-out -60.14, -20.67 APE8-rot-out 52.37 APE67-dihe-in -64.7, -19.44 -110.4, -17.18 APE12-dist-out 21.9032 APE11-dist-out 24.1105 APE10-dist-out 18.3702 APE9-dist-out 11.8681 None None None XRAY 1.489 0.186 0.195 A 360.0 348.0 1 25 24 1 [[24, 308]] 1.0 5r93 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R94A P47811 4 352 360.0 SOV:401 Allosteric Inactive DFGin 7.729 17.235 BLBminus -137.79, -178.74 55.84, 58.89 -57.59, 145.63 283.29, 72.29 -71.48, 114.45 in-in in 9.9283 Saltbr-in 2.9121 HRD-in -71.58, -53.08 83.28, -14.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.94, 131.9 APE9-dihe-na -62.45, -19.9 APE8-dihe-out -63.18, -16.73 APE8-rot-out 56.42 APE67-dihe-in -63.19, -21.64 -113.72, -19.73 APE12-dist-out 21.9777 APE11-dist-out 24.1871 APE10-dist-out 18.4441 APE9-dist-out 11.695 None None None XRAY 1.45 0.187 0.202 A 360.0 346.0 3 25 24 1 [[24, 308]] 1.0 5r94 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R95A P47811 4 352 360.0 SQ4:401 Allosteric Inactive DFGin 7.6695 17.1549 BLBminus -139.99, 179.44 56.08, 59.11 -58.27, 147.31 284.25, 68.55 -71.3, 107.79 in-in in 9.8852 Saltbr-in 2.8773 HRD-in -70.53, -53.74 79.75, -8.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.16, 132.42 APE9-dihe-na -63.75, -20.7 APE8-dihe-out -61.61, -19.73 APE8-rot-out 47.85 APE67-dihe-in -66.31, -19.82 -108.94, -17.23 APE12-dist-out 22.0039 APE11-dist-out 24.1865 APE10-dist-out 18.4173 APE9-dist-out 11.7229 None None None XRAY 1.59 0.192 0.204 A 360.0 346.0 3 25 24 1 [[24, 308]] 1.0 5r95 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R96A P47811 5 352 360.0 SQ7:401 Allosteric Inactive DFGin 7.6611 17.0905 BLBminus -136.37, -175.98 52.57, 61.74 -57.12, 147.65 283.47, 72.37 -70.19, 115.33 in-in in 9.8391 Saltbr-in 2.8116 HRD-in -68.37, -54.39 82.83, -12.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.21, 132.91 APE9-dihe-na -62.49, -21.62 APE8-dihe-out -60.28, -18.42 APE8-rot-out 52.24 APE67-dihe-in -64.9, -19.79 -112.71, -17.38 APE12-dist-out 21.9437 APE11-dist-out 24.187 APE10-dist-out 18.4437 APE9-dist-out 11.801 None None None XRAY 1.767 0.19 0.208 A 360.0 347.0 1 25 24 1 [[24, 308]] 1.0 5r96 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R98A P47811 5 352 360.0 SQG:401 Allosteric Inactive DFGin 7.6301 17.1531 BLBminus -139.69, -178.58 52.8, 60.22 -55.35, 146.47 284.25, 73.05 -71.74, 116.58 in-in in 9.8111 Saltbr-in 2.6872 HRD-in -69.0, -53.85 86.37, -15.46 in-out-out SNCioo out-out ActLoopNT-out 10.4878 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 131.88 APE9-dihe-na -62.6, -21.66 APE8-dihe-out -56.26, -26.27 APE8-rot-out 54.12 APE67-dihe-in -65.77, -18.3 -106.91, -14.96 APE12-dist-out 21.9117 APE11-dist-out 24.0966 APE10-dist-out 18.3637 APE9-dist-out 11.9084 None None None XRAY 1.68 0.183 0.2 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r98 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9AA P47811 5 352 360.0 SQM:401 Allosteric Inactive DFGin 7.5742 16.9369 BLBminus -126.82, 171.96 55.5, 57.75 -54.21, 144.16 285.22, 72.17 -66.56, 117.45 in-in in 9.7078 Saltbr-in 2.7238 HRD-in -69.92, -51.48 82.76, -10.56 in-out-out SNCioo out-out ActLoopNT-out 10.333 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.99, 130.14 APE9-dihe-na -62.59, -20.55 APE8-dihe-out -58.17, -22.41 APE8-rot-out 44.82 APE67-dihe-in -64.14, -18.64 -111.32, -17.69 APE12-dist-out 21.9802 APE11-dist-out 24.1461 APE10-dist-out 18.4075 APE9-dist-out 11.9533 None None None XRAY 1.53 0.196 0.208 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9a Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9BA P47811 5 352 360.0 JGM:401 Allosteric Inactive DFGin 7.7898 17.2212 BLBminus -137.89, -179.24 56.02, 58.96 -56.41, 146.75 282.82, 70.11 -71.44, 114.16 in-in in 9.7364 Saltbr-in 2.7607 HRD-in -71.08, -50.92 79.7, -15.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.68, 134.09 APE9-dihe-na -64.15, -19.43 APE8-dihe-out -62.84, -16.8 APE8-rot-out 55.38 APE67-dihe-in -65.51, -20.17 -113.81, -18.43 APE12-dist-out 21.9741 APE11-dist-out 24.2022 APE10-dist-out 18.4845 APE9-dist-out 11.7343 None None None XRAY 1.657 0.186 0.199 A 360.0 343.0 5 25 23 2 [[24, 308]] 1.0 5r9b Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9GA P47811 5 352 360.0 RGY:401 Allosteric Inactive DFGin 7.7265 17.0303 BLBminus -134.4, -175.55 57.07, 56.97 -55.58, 148.2 283.12, 71.34 -71.62, 105.51 in-in in 9.7003 Saltbr-in 2.7991 HRD-in -70.39, -55.26 82.6, -12.5 in-out-out SNCioo out-out ActLoopNT-out 10.9549 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.74, 135.25 APE9-dihe-na -63.35, -22.47 APE8-dihe-out -62.02, -18.5 APE8-rot-out 52.77 APE67-dihe-in -65.69, -20.71 -112.46, -19.93 APE12-dist-out 22.4508 APE11-dist-out 24.5661 APE10-dist-out 18.8167 APE9-dist-out 11.7175 None None None XRAY 1.73 0.177 0.195 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9g Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9HA P47811 5 352 360.0 SQV:401 Allosteric Inactive DFGin 7.6496 17.2459 BLBminus -137.89, -178.38 55.0, 58.67 -58.2, 147.67 282.66, 71.45 -69.93, 114.78 in-in in 9.9224 Saltbr-in 2.9457 HRD-in -70.31, -52.25 80.68, -10.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.63, 133.21 APE9-dihe-na -64.5, -19.28 APE8-dihe-out -61.91, -17.26 APE8-rot-out 53.17 APE67-dihe-in -64.9, -19.31 -113.89, -19.68 APE12-dist-out 21.9599 APE11-dist-out 24.1502 APE10-dist-out 18.3829 APE9-dist-out 11.7021 None None None XRAY 1.49 0.194 0.201 A 360.0 344.0 4 25 24 1 [[24, 308]] 1.0 5r9h Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9OA P47811 5 352 360.0 54F:401 Allosteric Inactive DFGin 7.6735 17.2107 BLBminus -136.39, -176.43 54.27, 60.09 -56.75, 144.98 283.51, 68.16 -67.8, 120.41 in-in in 9.802 Saltbr-in 2.8748 HRD-in -68.65, -55.19 86.09, -8.85 in-out-out SNCioo out-out ActLoopNT-out 10.3121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.85, 133.85 APE9-dihe-na -63.65, -21.53 APE8-dihe-out -61.93, -15.63 APE8-rot-out 53.56 APE67-dihe-in -63.52, -19.95 -117.35, -20.3 APE12-dist-out 21.9806 APE11-dist-out 24.1562 APE10-dist-out 18.3738 APE9-dist-out 11.8682 None None None XRAY 1.6 0.18 0.196 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9o Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9SA P47811 5 352 360.0 A9B:401 Allosteric Inactive DFGin 7.6484 17.0877 BLBminus -130.76, -174.94 52.61, 58.63 -54.81, 145.68 282.32, 73.37 -69.93, 118.55 in-in in 9.723 Saltbr-in 2.8924 HRD-in -68.6, -55.2 87.53, -15.82 in-out-out SNCioo out-out ActLoopNT-out 10.4211 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.15, 132.28 APE9-dihe-na -59.28, -26.61 APE8-dihe-out -57.14, -23.52 APE8-rot-out 51.46 APE67-dihe-in -63.1, -22.14 -110.76, -19.59 APE12-dist-out 22.0198 APE11-dist-out 24.1764 APE10-dist-out 18.3734 APE9-dist-out 11.8169 None None None XRAY 1.7 0.181 0.199 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9s Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9TA P47811 5 352 360.0 6T5:401 Allosteric Inactive DFGin 7.6529 17.225 BLBminus -134.58, 179.37 56.46, 61.42 -59.37, 143.77 284.46, 67.39 -62.94, 118.41 in-in in 9.747 Saltbr-in 2.8025 HRD-in -73.0, -49.97 79.73, -16.48 in-out-out SNCioo out-out ActLoopNT-out 10.4848 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.55, 133.75 APE9-dihe-na -63.67, -19.36 APE8-dihe-out -55.68, -28.19 APE8-rot-out 60.37 APE67-dihe-in -64.14, -18.0 -107.35, -18.11 APE12-dist-out 21.7698 APE11-dist-out 23.9495 APE10-dist-out 18.2248 APE9-dist-out 11.8023 None None None XRAY 1.8 0.193 0.222 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r9t Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9VA P47811 5 352 360.0 SSY:401 Allosteric Inactive DFGin 7.6279 17.0477 BLBminus -135.76, -174.98 54.29, 60.29 -54.36, 146.37 281.79, 73.25 -72.64, 118.79 in-in in 9.7606 Saltbr-in 2.8035 HRD-in -68.33, -52.97 82.92, -13.14 in-out-out SNCioo out-out ActLoopNT-out 10.3746 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.31, 133.8 APE9-dihe-na -62.94, -22.2 APE8-dihe-out -59.72, -21.1 APE8-rot-out 55.08 APE67-dihe-in -59.37, -22.0 -112.25, -26.14 APE12-dist-out 21.9536 APE11-dist-out 24.1672 APE10-dist-out 18.381 APE9-dist-out 11.6748 None None None XRAY 1.45 0.181 0.19 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9v Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9XA P47811 5 352 360.0 NZ4:401 Allosteric Inactive DFGin 7.6059 16.9807 BLBminus -133.11, -174.37 54.03, 59.46 -56.62, 145.82 285.46, 72.48 -68.38, 112.73 in-in in 9.81 Saltbr-in 2.8595 HRD-in -71.45, -53.15 83.16, -9.9 in-out-out SNCioo out-out ActLoopNT-out 10.0759 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.55, 132.59 APE9-dihe-na -64.28, -22.62 APE8-dihe-out -59.84, -17.55 APE8-rot-out 54.35 APE67-dihe-in -63.07, -20.46 -114.39, -20.36 APE12-dist-out 22.2549 APE11-dist-out 24.4395 APE10-dist-out 18.6278 APE9-dist-out 11.9119 None None None XRAY 1.72 0.18 0.202 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r9x Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9ZA P47811 5 352 360.0 AYS:401 Allosteric Inactive DFGin 7.6735 17.1058 BLBminus -133.13, -174.7 54.53, 56.1 -53.58, 144.14 285.01, 73.51 -69.81, 113.39 in-in in 9.8973 Saltbr-in 2.8298 HRD-in -68.34, -54.55 85.95, -12.36 in-out-out SNCioo out-out ActLoopNT-out 10.3695 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.12, 133.3 APE9-dihe-na -63.62, -25.19 APE8-dihe-out -57.92, -20.5 APE8-rot-out 51.08 APE67-dihe-in -62.29, -25.61 -112.35, -21.18 APE12-dist-out 22.1321 APE11-dist-out 24.2381 APE10-dist-out 18.4298 APE9-dist-out 11.7809 None None None XRAY 1.66 0.179 0.197 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9z Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA3A P47811 5 352 360.0 SVD:401 Allosteric Inactive DFGin 7.6779 16.9416 BLBminus -126.34, 179.2 56.7, 55.93 -51.74, 142.55 283.17, 74.34 -63.1, 112.19 in-in in 9.7539 Saltbr-in 2.7895 HRD-in -69.43, -52.58 81.78, -10.99 in-out-out SNCioo out-out ActLoopNT-out 10.5027 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.85, 132.04 APE9-dihe-na -60.7, -20.75 APE8-dihe-out -61.18, -22.1 APE8-rot-out 57.18 APE67-dihe-in -63.03, -21.89 -113.08, -19.76 APE12-dist-out 22.0459 APE11-dist-out 24.2893 APE10-dist-out 18.5343 APE9-dist-out 11.9139 None None None XRAY 1.57 0.212 0.229 A 360.0 345.0 3 25 25 0 [[24, 308]] 1.0 5ra3 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA4A P47811 5 352 360.0 SVG:401 Allosteric Inactive DFGin 7.653 17.0437 BLBminus -130.79, -174.79 52.38, 60.78 -56.74, 147.03 281.5, 76.16 -70.86, 116.26 in-in in 9.729 Saltbr-in 2.8302 HRD-in -71.41, -53.27 80.45, -7.1 in-out-out SNCioo out-out ActLoopNT-out 10.3013 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.54, 132.79 APE9-dihe-na -63.25, -22.78 APE8-dihe-out -60.03, -18.29 APE8-rot-out 51.8 APE67-dihe-in -64.64, -18.17 -114.64, -21.82 APE12-dist-out 21.9864 APE11-dist-out 24.2049 APE10-dist-out 18.4197 APE9-dist-out 11.7767 None None None XRAY 1.59 0.184 0.199 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra4 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA5A P47811 5 352 360.0 SVJ:401 Allosteric Inactive DFGin 7.6769 17.1318 BLBminus -134.61, -174.21 50.91, 61.55 -54.67, 146.72 280.99, 77.86 -69.78, 116.61 in-in in 9.7787 Saltbr-in 2.8482 HRD-in -69.58, -53.21 81.06, -8.28 in-out-out SNCioo out-out ActLoopNT-out 10.0897 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.75, 130.27 APE9-dihe-na -62.89, -20.53 APE8-dihe-out -60.05, -19.39 APE8-rot-out 51.5 APE67-dihe-in -65.85, -14.96 -114.99, -21.7 APE12-dist-out 22.0635 APE11-dist-out 24.3067 APE10-dist-out 18.5468 APE9-dist-out 11.7651 None None None XRAY 1.54 0.183 0.198 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra5 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOIA P47811 4 352 360.0 LOK:401 Allosteric Inactive DFGin 7.6003 17.1296 BLBminus -138.61, -177.05 54.96, 58.72 -56.67, 146.48 284.49, 69.56 -71.01, 109.8 in-in in 9.8435 Saltbr-in 2.8732 HRD-in -70.18, -53.83 83.4, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.67, 133.12 APE9-dihe-na -65.95, -18.62 APE8-dihe-out -58.87, -19.51 APE8-rot-out 50.31 APE67-dihe-in -63.43, -19.73 -113.68, -18.38 APE12-dist-out 22.0101 APE11-dist-out 24.195 APE10-dist-out 18.4783 APE9-dist-out 11.7667 None None None XRAY 1.55 0.211 0.234 A 380.0 346.0 3 25 24 1 [[24, 308]] 1.0 6soi Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SO1A P47811 5 352 360.0 LO5:401 Allosteric Inactive DFGin 7.658 17.0391 BLBminus -135.08, -176.54 51.6, 60.96 -56.09, 146.29 284.52, 70.34 -67.64, 113.41 in-in in 9.8471 Saltbr-in 2.8249 HRD-in -69.25, -52.88 79.19, -11.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.6, 132.96 APE9-dihe-na -61.83, -21.36 APE8-dihe-out -63.21, -14.73 APE8-rot-out 51.84 APE67-dihe-in -64.64, -20.67 -114.01, -18.86 APE12-dist-out 21.9498 APE11-dist-out 24.1112 APE10-dist-out 18.3716 APE9-dist-out 11.6413 None None None XRAY 1.66 0.187 0.204 A 381.0 343.0 5 25 23 2 [[24, 308]] 1.0 6so1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SO2A P47811 4 352 360.0 JGG:401 Allosteric Inactive DFGin 7.6274 16.9267 BLBminus -135.57, 179.75 55.15, 60.68 -57.52, 146.11 285.62, 69.71 -68.14, 118.76 in-in in 9.8446 Saltbr-in 2.7969 HRD-in -70.11, -51.91 80.58, -12.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 132.29 APE9-dihe-na -61.32, -22.39 APE8-dihe-out -62.87, -12.7 APE8-rot-out 57.5 APE67-dihe-in -63.09, -21.09 -115.95, -19.85 APE12-dist-out 22.0177 APE11-dist-out 24.188 APE10-dist-out 18.4392 APE9-dist-out 11.673 None None None XRAY 1.6 0.185 0.193 A 381.0 345.0 4 25 23 2 [[24, 308]] 1.0 6so2 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SO4A P47811 5 352 360.0 LO8:401 Allosteric Inactive DFGin 7.5993 17.0443 BLBminus -135.53, -177.23 56.32, 58.65 -57.36, 146.69 283.65, 71.71 -69.82, 110.96 in-in in 9.768 Saltbr-in 2.7738 HRD-in -71.08, -52.37 79.77, -9.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.06, 133.58 APE9-dihe-na -64.96, -18.16 APE8-dihe-out -63.58, -15.55 APE8-rot-out 53.76 APE67-dihe-in -66.99, -20.52 -115.06, -16.09 APE12-dist-out 22.0173 APE11-dist-out 24.1969 APE10-dist-out 18.446 APE9-dist-out 11.773 None None None XRAY 1.51 0.214 0.228 A 381.0 343.0 5 25 23 2 [[24, 308]] 1.0 6so4 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SODA P47811 5 352 360.0 LOE:401 Allosteric Inactive DFGin 7.5743 17.0706 BLBminus -137.18, -176.29 55.07, 60.36 -59.01, 143.71 284.33, 71.06 -68.11, 116.87 in-none in 9.905 Saltbr-none 999.0 HRD-in -67.45, -53.5 81.24, -11.19 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.73, 132.94 APE9-dihe-na -62.6, -20.06 APE8-dihe-out -63.14, -19.99 APE8-rot-out 54.04 APE67-dihe-in -64.93, -19.97 -108.41, -16.54 APE12-dist-out 22.022 APE11-dist-out 24.1848 APE10-dist-out 18.4227 APE9-dist-out 11.8419 None None None XRAY 1.87 0.191 0.204 A 381.0 345.0 3 25 23 2 [[24, 308]] 1.0 6sod Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOTA P47811 5 352 360.0 LOQ:401 Allosteric Inactive DFGin 7.6209 17.0755 BLBminus -135.94, -177.19 53.97, 59.82 -55.74, 146.14 283.57, 73.95 -69.99, 114.99 in-in in 9.8146 Saltbr-in 2.8826 HRD-in -69.44, -54.13 83.61, -15.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.13, 133.72 APE9-dihe-na -65.65, -18.12 APE8-dihe-out -63.48, -14.82 APE8-rot-out 46.93 APE67-dihe-in -63.68, -20.51 -114.08, -19.2 APE12-dist-out 21.9926 APE11-dist-out 24.1895 APE10-dist-out 18.4162 APE9-dist-out 11.6962 None None None XRAY 1.54 0.211 0.231 A 381.0 342.0 6 25 23 2 [[24, 308]] 1.0 6sot Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9MA P47811 5 352 360.0 A7K:401,A7K:402 Allosteric,Allosteric Inactive DFGin 7.5883 17.1408 BLBminus -136.87, -176.16 51.91, 61.14 -56.97, 145.87 284.55, 73.06 -74.07, 108.58 in-in in 9.9746 Saltbr-in 2.9082 HRD-in -68.84, -53.47 83.15, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.61, 132.14 APE9-dihe-na -63.64, -20.07 APE8-dihe-out -60.41, -20.56 APE8-rot-out 51.41 APE67-dihe-in -66.6, -19.97 -109.87, -16.5 APE12-dist-out 22.046 APE11-dist-out 24.1829 APE10-dist-out 18.4294 APE9-dist-out 11.8105 None None None XRAY 1.809 0.184 0.199 A 360.0 341.0 7 25 23 2 [[24, 308]] 1.0 5r9m Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1LEWA P47811 5 354 360.0 No_ligand No_ligand Inactive DFGin 7.4633 16.4972 BLBminus -127.25, -179.22 41.37, 70.66 -65.36, 149.47 289.38, 51.62 -76.18, 122.9 in-in in 9.8118 Saltbr-in 2.6178 HRD-in -60.7, -50.62 75.36, -7.59 in-out-out SNCioo out-out ActLoopNT-out 9.0538 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -152.34 APE9-dihe-na -143.4, -102.57 APE8-dihe-out -17.97, -56.94 APE8-rot-in 286.63 APE67-dihe-in -60.23, -19.01 -51.04, -36.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.8616 APE9-dist-out 11.5335 None None None XRAY 2.3 0.245 0.257 A 360.0 341.0 9 25 16 9 [[24, 308]] 1.0 1lew Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1LEZA P47811 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.4321 16.6258 BLBminus -119.38, -179.63 36.99, 72.05 -62.99, 142.29 290.92, 58.12 -68.79, 128.84 in-in in 9.8378 Saltbr-in 3.0077 HRD-in -59.03, -47.57 75.45, -14.7 in-out-out SNCioo out-out ActLoopNT-out 10.4145 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 154.62, 130.36 APE9-dihe-na -61.38, -56.46 APE8-dihe-out -54.42, -46.27 APE8-rot-in 286.56 APE67-dihe-in -60.01, -23.17 -59.69, -32.97 APE12-dist-none 999.0 APE11-dist-out 23.2792 APE10-dist-out 17.9984 APE9-dist-out 11.4669 None None None XRAY 2.3 0.247 0.249 A 360.0 343.0 7 25 18 7 [[24, 308]] 1.0 1lez Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4KA3A P47811 4 354 360.0 No_ligand No_ligand Inactive DFGin 7.3535 16.1489 BLBminus -139.92, 169.36 58.93, 50.7 -50.8, 136.6 293.23, 65.74 -57.05, 132.74 in-in in 9.5702 Saltbr-in 3.0125 HRD-in -64.83, -49.71 85.54, -7.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -81.99 APE8-dihe-out -71.42, -34.21 APE8-rot-out 228.85 APE67-dihe-in -64.35, -21.2 -64.38, -26.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8827 None None None XRAY 2.707 0.225 0.267 A 360.0 340.0 11 25 14 11 [[24, 308]] 1.0 4ka3 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8YPFA P47811 5 353 360.0 No_ligand No_ligand Inactive DFGin 8.0231 16.7688 BLBminus -111.38, 168.27 61.8, 65.14 -68.47, 150.01 282.99, 63.86 -56.92, 999.0 in-in in 9.7222 Saltbr-in 2.774 HRD-in -71.93, -50.08 76.29, -10.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -20.77 APE8-dihe-out -57.69, -40.15 APE8-rot-in 268.26 APE67-dihe-in -62.53, -21.95 -63.26, -31.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5207 None None None XRAY 2.0 0.192 0.218 A 360.0 336.0 13 25 12 13 [[24, 308]] 1.0 8ypf Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8YPEA P47811 1 353 360.0 No_ligand No_ligand Inactive DFGin 8.0712 16.6118 BLBminus -119.57, 172.41 55.63, 61.52 -65.14, 145.77 279.11, 61.33 -71.59, 117.4 in-in in 9.4469 Saltbr-in 2.7496 HRD-in -67.38, -46.31 76.43, -18.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.73 APE8-dihe-in -75.24, 139.72 APE8-rot-out 185.33 APE67-dihe-in -59.42, -19.13 -105.03, 0.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8293 None None None XRAY 1.95 0.198 0.225 A 362.0 342.0 11 25 14 11 [[24, 308]] 1.0 8ype Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P4KA P47811 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.6209 16.6942 BLBminus -115.36, 175.26 45.65, 64.94 -53.3, 144.21 298.72, 64.73 -77.54, 138.8 in-in in 9.8102 Saltbr-in 3.1274 HRD-in -69.1, -51.07 78.1, -17.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 6.46 APE8-dihe-out 65.74, 112.23 APE8-rot-in 292.55 APE67-dihe-in -66.06, -22.6 -109.02, -6.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9676 S28A None None XRAY 2.304 0.179 0.239 A 370.0 338.0 12 25 13 12 [[24, 308]] 1.0 3p4k Mus musculus CMGC_MAPK14_MOUSE CMGC 2.6e-85 292.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5UOJA P47811 5 353 360.0 No_ligand No_ligand Inactive DFGin 7.3433 16.9665 BLBminus -124.98, 174.69 53.78, 57.97 -59.14, 144.23 289.53, 74.34 -78.97, 103.61 out-out out 10.0861 Saltbr-out 5.3395 HRD-in -64.82, -55.28 79.99, -9.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.38, 126.07 APE9-dihe-na -49.77, -40.48 APE8-dihe-out -57.2, -40.83 APE8-rot-out 188.73 APE67-dihe-in -64.28, -25.71 -72.72, -20.17 APE12-dist-out 22.2949 APE11-dist-out 24.5513 APE10-dist-out 18.7898 APE9-dist-out 11.9987 None None None XRAY 2.1 0.157 0.214 A 379.0 343.0 6 25 19 6 [[24, 308]] 1.0 5uoj Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8YP8A P47811 1 353 360.0 No_ligand No_ligand Inactive DFGin 8.0379 16.5298 BLBminus -114.8, 172.08 51.68, 65.57 -64.23, 147.07 283.41, 55.34 -60.66, 123.06 in-in in 9.1931 Saltbr-in 2.7009 HRD-in -65.26, -50.86 84.01, -20.01 in-out-none SNCion out-none ActLoopNT-out 10.1901 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.82 APE8-rot-in 277.38 APE67-dihe-in -54.85, -21.48 -97.3, -3.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.188 0.216 A 379.0 342.0 11 25 14 11 [[24, 308]] 1.0 8yp8 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7Z9TAAA P47811 5 353 360.0 87B:401 Type1 Inactive DFGin 6.1799 14.3876 BLBminus -108.1, 162.59 42.6, 96.25 -71.23, -179.32 304.54, 85.44 -93.8, 149.18 in-out in 9.2965 Saltbr-out 3.9379 HRD-in -77.72, -47.19 81.78, -30.3 out-out-out SNCooo out-out ActLoopNT-out 8.3976 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioo APE10-dihe-na -85.06, 132.75 APE9-dihe-na 75.21, 146.99 APE8-dihe-out 119.98, 103.46 APE8-rot-in 302.55 APE67-dihe-out 103.66, -39.72 -131.02, -136.12 APE12-dist-in 9.4331 APE11-dist-in 13.4939 APE10-dist-out 16.5523 APE9-dist-out 13.5575 None None None XRAY 2.6 0.202 0.254 AAA 359.0 349.0 0 25 25 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R90A P47811 4 352 360.0 SNJ:401 Type1 Inactive DFGin 7.6678 17.1876 BLBminus -137.94, -179.67 55.83, 58.82 -58.12, 146.21 285.38, 69.63 -67.29, 110.69 in-in in 9.6857 Saltbr-in 2.7825 HRD-in -71.16, -54.19 86.61, -16.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.9, 133.58 APE9-dihe-na -63.36, -19.08 APE8-dihe-out -63.12, -16.3 APE8-rot-out 58.59 APE67-dihe-in -65.84, -19.02 -114.37, -18.56 APE12-dist-out 22.0506 APE11-dist-out 24.1928 APE10-dist-out 18.4205 APE9-dist-out 11.7021 None None None XRAY 1.619 0.184 0.198 A 360.0 342.0 7 25 23 2 [[24, 308]] 1.0 5r90 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R91A P47811 5 352 360.0 SNV:401 Type1 Inactive DFGin 7.6892 17.1017 BLBminus -138.11, -177.81 53.58, 59.52 -57.75, 148.02 285.48, 71.66 -68.32, 105.39 in-in in 9.8399 Saltbr-in 2.7668 HRD-in -70.49, -52.89 81.31, -9.72 in-out-out SNCioo out-out ActLoopNT-out 10.9195 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 133.54 APE9-dihe-na -65.2, -19.43 APE8-dihe-out -60.64, -19.49 APE8-rot-out 50.11 APE67-dihe-in -65.3, -20.01 -110.38, -17.53 APE12-dist-out 22.3332 APE11-dist-out 24.4377 APE10-dist-out 18.6723 APE9-dist-out 11.8048 None None None XRAY 1.731 0.179 0.197 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r91 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R92A P47811 4 352 360.0 SO7:401 Type1 Inactive DFGin 7.5236 16.8486 BLBminus -127.62, 174.22 55.6, 60.05 -58.63, 146.88 285.47, 71.59 -64.4, 110.17 in-in in 9.6359 Saltbr-in 2.7009 HRD-in -71.14, -53.35 82.46, -11.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.37, 133.3 APE9-dihe-na -64.94, -17.52 APE8-dihe-out -63.53, -14.79 APE8-rot-out 55.16 APE67-dihe-in -64.99, -20.47 -115.68, -17.83 APE12-dist-out 22.0338 APE11-dist-out 24.1639 APE10-dist-out 18.3837 APE9-dist-out 11.7603 None None None XRAY 1.66 0.183 0.205 A 360.0 345.0 4 25 23 2 [[24, 308]] 1.0 5r92 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R99A P47811 5 352 360.0 SU7:401 Type1 Inactive DFGin 7.8919 17.0151 BLBminus -146.47, -177.12 52.77, 56.64 -55.85, 150.41 288.84, 66.98 -63.34, 105.63 in-in in 9.7647 Saltbr-in 2.7742 HRD-in -68.42, -53.33 83.16, -8.93 in-out-out SNCioo out-out ActLoopNT-out 10.9625 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.99, 135.36 APE9-dihe-na -67.72, -15.25 APE8-dihe-out -63.51, -18.59 APE8-rot-out 52.29 APE67-dihe-in -68.76, -20.75 -110.99, -17.46 APE12-dist-out 22.3537 APE11-dist-out 24.4662 APE10-dist-out 18.7111 APE9-dist-out 11.8436 None None None XRAY 1.89 0.18 0.206 A 360.0 344.0 4 25 25 0 [[24, 308]] 1.0 5r99 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9CA P47811 5 352 360.0 7ZC:401 Type1 Inactive DFGin 7.5773 17.1293 BLBminus -141.23, -179.44 54.44, 56.72 -53.76, 145.23 285.6, 70.26 -70.39, 113.88 in-in in 9.8675 Saltbr-in 2.8998 HRD-in -71.35, -53.13 82.1, -11.29 in-out-out SNCioo out-out ActLoopNT-out 10.3545 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.84, 135.25 APE9-dihe-na -67.14, -15.45 APE8-dihe-out -63.46, -16.84 APE8-rot-out 55.99 APE67-dihe-in -63.3, -20.21 -113.78, -20.26 APE12-dist-out 21.9461 APE11-dist-out 24.1229 APE10-dist-out 18.3797 APE9-dist-out 11.7482 None None None XRAY 1.74 0.192 0.213 A 360.0 347.0 1 25 25 0 [[24, 308]] 1.0 5r9c Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9FA P47811 5 352 360.0 SQP:401 Type1 Inactive DFGin 7.577 17.2001 BLBminus -138.11, -177.8 54.45, 59.57 -54.39, 144.45 283.25, 74.16 -72.98, 105.78 in-in in 9.9225 Saltbr-in 2.8257 HRD-in -69.53, -50.61 81.72, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.86, 133.81 APE9-dihe-na -67.51, -18.17 APE8-dihe-out -65.56, -14.21 APE8-rot-out 67.06 APE67-dihe-in -66.44, -16.84 -108.39, -19.86 APE12-dist-out 22.2441 APE11-dist-out 24.319 APE10-dist-out 18.5556 APE9-dist-out 11.813 None None None XRAY 1.986 0.177 0.199 A 360.0 345.0 3 25 24 1 [[24, 308]] 1.0 5r9f Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9IA P47811 5 352 360.0 SQY:401 Type1 Inactive DFGin 7.6506 16.7346 BLBminus -138.77, -175.92 52.06, 60.96 -58.66, 151.66 285.82, 66.28 -70.04, 105.31 in-in in 9.7286 Saltbr-in 2.7464 HRD-in -70.61, -53.18 78.34, -9.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.64, 135.26 APE9-dihe-na -64.93, -19.54 APE8-dihe-out -56.77, -20.74 APE8-rot-out 56.09 APE67-dihe-in -66.12, -19.98 -114.56, -18.68 APE12-dist-out 22.177 APE11-dist-out 24.3357 APE10-dist-out 18.5725 APE9-dist-out 11.812 None None None XRAY 1.813 0.19 0.213 A 360.0 337.0 11 25 23 2 [[24, 308]] 1.0 5r9i Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9JA P47811 4 352 360.0 LXS:401 Type1 Inactive DFGin 7.6571 17.0258 BLBminus -137.87, -174.87 52.75, 58.86 -56.97, 144.58 283.44, 74.63 -70.59, 113.99 in-in in 9.6181 Saltbr-in 2.7535 HRD-in -68.84, -53.0 82.84, -15.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.39, 133.05 APE9-dihe-na -62.87, -19.75 APE8-dihe-out -59.33, -18.78 APE8-rot-out 51.6 APE67-dihe-in -64.82, -20.61 -116.02, -18.59 APE12-dist-out 21.9424 APE11-dist-out 24.134 APE10-dist-out 18.3934 APE9-dist-out 11.6987 None None None XRAY 1.52 0.191 0.208 A 360.0 344.0 5 25 24 1 [[24, 308]] 1.0 5r9j Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9LA P47811 4 352 360.0 SRJ:401 Type1 Inactive DFGin 7.648 17.1665 BLBminus -137.24, -178.63 56.93, 57.66 -59.32, 148.24 285.59, 71.06 -65.89, 117.05 in-in in 9.8182 Saltbr-in 2.7309 HRD-in -70.18, -52.62 82.55, -14.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.15, 131.29 APE9-dihe-na -63.61, -17.95 APE8-dihe-out -62.94, -16.32 APE8-rot-out 54.19 APE67-dihe-in -65.18, -20.54 -116.22, -18.56 APE12-dist-out 22.2098 APE11-dist-out 24.3683 APE10-dist-out 18.6195 APE9-dist-out 11.7308 None None None XRAY 1.47 0.191 0.2 A 360.0 342.0 7 25 23 2 [[24, 308]] 1.0 5r9l Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9NA P47811 4 352 360.0 JFS:401 Type1 Inactive DFGin 7.2909 16.7195 BLBminus -138.51, -178.9 58.55, 56.04 -54.08, 142.66 293.5, 73.44 -65.71, 113.38 out-out out 10.0151 Saltbr-out 5.3183 HRD-in -70.07, -53.6 81.73, -12.32 out-out-out SNCooo out-out ActLoopNT-out 10.1676 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.19, 133.63 APE9-dihe-na -63.94, -18.01 APE8-dihe-out -64.45, -14.4 APE8-rot-out 52.46 APE67-dihe-in -66.98, -18.95 -115.67, -16.53 APE12-dist-out 22.0365 APE11-dist-out 24.2525 APE10-dist-out 18.5634 APE9-dist-out 11.8389 None None None XRAY 1.688 0.188 0.202 A 360.0 342.0 7 25 25 0 [[24, 308]] 1.0 5r9n Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9PA P47811 5 352 360.0 SFY:401 Type1 Inactive DFGin 7.6143 16.8757 BLBminus -134.95, -173.36 51.9, 61.23 -57.06, 147.19 281.19, 76.44 -71.38, 111.1 in-in in 9.7067 Saltbr-in 2.8914 HRD-in -69.15, -54.71 83.47, -8.94 in-out-out SNCioo out-out ActLoopNT-out 10.2835 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.97, 131.95 APE9-dihe-na -63.13, -23.64 APE8-dihe-out -56.65, -23.63 APE8-rot-out 53.53 APE67-dihe-in -64.7, -21.71 -111.61, -19.66 APE12-dist-out 22.1855 APE11-dist-out 24.4362 APE10-dist-out 18.6481 APE9-dist-out 11.8611 None None None XRAY 1.72 0.175 0.195 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9p Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9RA P47811 5 352 360.0 K3D:401 Type1 Inactive DFGin 7.6673 16.9236 BLBminus -129.0, -176.69 57.76, 58.0 -55.55, 141.14 284.38, 72.22 -64.01, 110.17 in-in in 9.6896 Saltbr-in 2.7508 HRD-in -70.35, -55.62 82.21, -8.65 in-out-out SNCioo out-out ActLoopNT-out 9.9925 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.16, 137.0 APE9-dihe-na -65.4, -23.34 APE8-dihe-out -58.91, -19.74 APE8-rot-out 53.94 APE67-dihe-in -66.7, -22.91 -113.45, -18.81 APE12-dist-out 22.1706 APE11-dist-out 24.3197 APE10-dist-out 18.558 APE9-dist-out 11.7424 None None None XRAY 1.76 0.184 0.208 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9r Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9YA P47811 5 352 360.0 SU7:401 Type1 Inactive DFGin 7.6107 16.7458 BLBminus -132.18, -177.15 58.83, 54.05 -56.42, 145.76 286.43, 69.73 -66.03, 113.41 in-in in 9.6217 Saltbr-in 2.7825 HRD-in -69.32, -54.06 79.79, -4.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.67, 132.15 APE9-dihe-na -60.68, -23.39 APE8-dihe-out -59.13, -20.87 APE8-rot-out 48.76 APE67-dihe-in -63.42, -22.61 -113.67, -21.11 APE12-dist-out 22.1602 APE11-dist-out 24.3308 APE10-dist-out 18.5042 APE9-dist-out 11.7642 None None None XRAY 1.57 0.191 0.21 A 360.0 343.0 5 25 23 2 [[24, 308]] 1.0 5r9y Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA0A P47811 5 352 360.0 JFS:401 Type1 Inactive DFGin 7.3881 16.6282 BLBminus -139.8, -179.89 61.67, 49.29 -47.07, 133.74 290.08, 80.21 -62.39, 114.23 in-out in 9.9582 Saltbr-out 3.6218 HRD-in -63.09, -59.13 79.95, -2.63 out-out-out SNCooo out-out ActLoopNT-out 10.1829 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.61, 135.91 APE9-dihe-na -61.52, -28.35 APE8-dihe-out -56.52, -21.44 APE8-rot-out 43.53 APE67-dihe-in -59.92, -23.96 -112.03, -20.42 APE12-dist-out 22.0698 APE11-dist-out 24.3591 APE10-dist-out 18.6303 APE9-dist-out 11.8176 None None None XRAY 1.91 0.221 0.257 A 360.0 345.0 3 25 25 0 [[24, 308]] 1.0 5ra0 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA2A P47811 5 352 360.0 SV4:401 Type1 Inactive DFGin 7.3562 16.6064 BLBminus -133.83, -175.71 56.35, 56.82 -54.49, 147.53 281.75, 74.23 -71.39, 117.12 in-in in 9.6168 Saltbr-in 2.8915 HRD-in -69.98, -52.36 81.07, -5.94 in-out-out SNCioo out-out ActLoopNT-out 10.3532 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 129.32 APE9-dihe-na -60.35, -23.28 APE8-dihe-out -58.5, -19.86 APE8-rot-out 51.08 APE67-dihe-in -65.0, -18.22 -114.68, -19.44 APE12-dist-out 22.0844 APE11-dist-out 24.3177 APE10-dist-out 18.5372 APE9-dist-out 11.8258 None None None XRAY 1.57 0.181 0.197 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra2 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA6A P47811 5 352 360.0 SVM:401 Type1 Inactive DFGin 7.5889 16.0324 BLBminus -139.6, -174.08 52.01, 57.31 -49.9, 142.73 286.08, 73.95 -66.7, 117.63 in-in in 9.2467 Saltbr-in 3.0371 HRD-in -68.79, -56.26 81.52, -15.74 in-out-out SNCioo out-out ActLoopNT-out 10.6264 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.89, 133.47 APE9-dihe-na -60.81, -24.0 APE8-dihe-out -60.22, -21.55 APE8-rot-out 52.3 APE67-dihe-in -65.92, -20.79 -111.03, -20.17 APE12-dist-out 22.1965 APE11-dist-out 24.3921 APE10-dist-out 18.6186 APE9-dist-out 11.8294 None None None XRAY 1.86 0.185 0.211 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra6 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPB P47811 4 353 360.0 SB4:401 Type1 Inactive DFGin 7.8789 16.3745 BLBminus -134.89, -174.36 58.03, 55.66 -54.0, 135.64 290.0, 65.54 -94.36, 162.11 in-in in 9.4514 Saltbr-in 2.6901 HRD-in -69.75, -47.82 68.57, -12.57 in-out-out SNCioo out-out ActLoopNT-out 10.1643 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.51, -58.02 APE9-dihe-na -61.88, -35.33 APE8-dihe-out -56.88, -41.69 APE8-rot-in 289.42 APE67-dihe-in -68.96, -24.95 -50.74, -35.93 APE12-dist-in 11.7137 APE11-dist-in 11.2256 APE10-dist-out 16.2318 APE9-dist-out 10.7437 None None None XRAY 2.049 0.228 0.188 B 361.0 350.0 0 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPC P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 7.7603 16.3394 BLBminus -138.68, -179.91 58.54, 57.09 -52.32, 141.55 291.05, 61.14 -104.09, 166.76 in-in in 9.394 Saltbr-in 2.6296 HRD-in -64.21, -53.16 81.3, -13.91 in-out-out SNCioo out-out ActLoopNT-out 10.4136 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -64.28, -49.56 APE9-dihe-na -71.52, -38.16 APE8-dihe-out -51.64, -44.73 APE8-rot-in 286.45 APE67-dihe-in -62.39, -31.11 -56.8, -34.2 APE12-dist-in 11.7581 APE11-dist-in 11.1864 APE10-dist-out 16.1472 APE9-dist-out 10.5473 None None None XRAY 2.049 0.228 0.188 C 361.0 341.0 10 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQA P47811 3 354 360.0 SB4:401 Type1 Inactive DFGin 8.0914 16.5138 BLBminus -141.84, 179.49 59.16, 69.82 -70.4, 139.6 288.89, 66.48 -101.36, 159.57 in-in in 9.448 Saltbr-in 2.4527 HRD-in -63.24, -57.34 88.41, -26.01 in-out-out SNCioo out-out ActLoopNT-out 9.6357 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -73.62, -46.85 APE9-dihe-na -75.71, -36.69 APE8-dihe-out -50.54, -37.31 APE8-rot-in 285.03 APE67-dihe-in -71.18, -20.34 -59.58, -32.47 APE12-dist-in 12.3242 APE11-dist-in 11.7871 APE10-dist-out 16.5681 APE9-dist-out 10.7936 None None None XRAY 2.319 0.291 0.236 A 361.0 352.0 0 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQB P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 7.8608 16.4006 BLBminus -142.86, 179.87 59.5, 70.14 -71.25, 135.97 289.99, 66.27 -95.3, 157.33 in-in in 9.4879 Saltbr-in 2.4264 HRD-in -64.66, -55.98 86.54, -20.06 in-out-out SNCioo out-out ActLoopNT-out 9.7138 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -75.32, -49.2 APE9-dihe-na -70.98, -42.84 APE8-dihe-out -44.43, -42.98 APE8-rot-in 289.25 APE67-dihe-in -71.01, -21.66 -60.96, -27.97 APE12-dist-in 12.2296 APE11-dist-in 11.6993 APE10-dist-out 16.5334 APE9-dist-out 10.8468 None None None XRAY 2.319 0.291 0.236 B 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQC P47811 4 353 360.0 SB4:401 Type1 Inactive DFGin 7.9346 16.4509 BLBminus -143.64, -179.12 58.91, 71.41 -71.13, 135.9 289.34, 66.9 -100.37, 152.54 in-in in 9.454 Saltbr-in 2.4434 HRD-in -65.05, -60.56 91.58, -20.02 in-out-out SNCioo out-out ActLoopNT-out 9.6801 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -77.12, -46.24 APE9-dihe-na -71.56, -37.42 APE8-dihe-out -50.1, -40.93 APE8-rot-in 287.94 APE67-dihe-in -67.77, -24.08 -57.92, -34.79 APE12-dist-in 12.1975 APE11-dist-in 11.6785 APE10-dist-out 16.5514 APE9-dist-out 10.668 None None None XRAY 2.319 0.291 0.236 C 361.0 337.0 13 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQD P47811 4 354 360.0 SB4:401 Type1 Inactive DFGin 7.9252 16.3392 BLBminus -137.78, -176.18 55.52, 70.52 -70.14, 135.43 292.15, 66.71 -98.76, 156.08 in-in in 9.5121 Saltbr-in 2.4763 HRD-in -69.33, -57.76 89.49, -22.47 in-out-out SNCioo out-out ActLoopNT-out 9.7908 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -75.18, -46.22 APE9-dihe-na -71.04, -39.79 APE8-dihe-out -50.99, -35.23 APE8-rot-in 287.27 APE67-dihe-in -69.51, -20.49 -61.37, -33.69 APE12-dist-in 12.2648 APE11-dist-in 11.7656 APE10-dist-out 16.5713 APE9-dist-out 10.6883 None None None XRAY 2.319 0.291 0.236 D 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8UA P47811 5 352 360.0 SLS:401 Type1.5_Back Inactive DFGin 7.9973 16.7294 BLBminus -114.75, 170.33 94.23, 75.22 -129.34, 124.66 295.54, 92.34 76.49, 17.64 in-in in 9.3283 Saltbr-in 2.8371 HRD-in -74.34, -52.41 80.29, -13.59 in-out-out SNCioo out-out ActLoopNT-out 11.0433 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -135.11, 132.18 APE9-dihe-na -60.6, -25.64 APE8-dihe-out -66.72, -13.83 APE8-rot-in 303.39 APE67-dihe-in -64.83, -21.18 -106.8, -21.17 APE12-dist-out 21.8654 APE11-dist-out 23.6946 APE10-dist-out 17.8181 APE9-dist-out 11.3763 None None None XRAY 1.48 0.181 0.198 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r8u Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA7A P47811 5 352 360.0 SW7:401 Type1.5_Back Inactive DFGin 7.8717 16.8284 BLBminus -109.87, 168.39 99.38, 71.14 -119.28, 122.94 290.21, 91.33 72.87, 24.0 in-in in 9.3529 Saltbr-in 3.1224 HRD-in -67.43, -52.94 77.22, -9.02 in-out-out SNCioo out-out ActLoopNT-out 11.3078 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.7, 133.67 APE9-dihe-na -56.89, -35.11 APE8-dihe-out -58.78, -22.98 APE8-rot-out 50.89 APE67-dihe-in -63.4, -23.94 -102.22, -22.93 APE12-dist-out 21.9431 APE11-dist-out 23.7872 APE10-dist-out 17.8834 APE9-dist-out 11.6895 None None None XRAY 1.92 0.18 0.209 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra7 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA8A P47811 5 352 360.0 2O6:401 Type1.5_Back Inactive DFGin 8.0262 17.03 BLBminus -107.95, 170.65 89.03, 79.85 -127.96, 127.66 291.36, 90.97 75.31, 22.6 in-in in 9.2733 Saltbr-in 2.8891 HRD-in -68.33, -55.58 80.75, -13.24 in-out-out SNCioo out-out ActLoopNT-out 11.2235 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.91, 134.0 APE9-dihe-na -63.22, -27.25 APE8-dihe-out -60.6, -13.44 APE8-rot-out 50.23 APE67-dihe-in -63.41, -23.94 -112.77, -25.02 APE12-dist-out 22.0108 APE11-dist-out 23.8485 APE10-dist-out 17.9216 APE9-dist-out 11.5735 None None None XRAY 1.78 0.183 0.21 A 360.0 344.0 4 25 25 0 [[24, 308]] 1.0 5ra8 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8YA P47811 4 352 360.0 SMV:401 Type3 Inactive DFGin 7.9 16.7927 BLBminus -115.18, 174.46 86.01, 79.12 -130.02, 131.19 294.34, 93.85 77.63, 13.6 in-in in 9.45 Saltbr-in 2.815 HRD-in -72.91, -49.09 80.16, -14.98 in-out-out SNCioo out-out ActLoopNT-out 11.08 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.04, 132.68 APE9-dihe-na -64.1, -21.25 APE8-dihe-out -66.93, -11.24 APE8-rot-out 49.29 APE67-dihe-in -64.72, -20.5 -110.83, -19.65 APE12-dist-out 21.8896 APE11-dist-out 23.669 APE10-dist-out 17.819 APE9-dist-out 11.5053 None None None XRAY 1.679 0.179 0.198 A 360.0 346.0 3 25 25 0 [[24, 308]] 1.0 5r8y Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8ZA P47811 5 352 360.0 SN4:401 Type3 Inactive DFGin 8.0828 16.7805 BLBminus -109.77, 173.86 86.86, 76.26 -126.38, 131.11 295.21, 88.72 77.15, 15.55 in-in in 9.4374 Saltbr-in 2.7482 HRD-in -74.55, -50.34 76.91, -8.98 in-out-out SNCioo out-out ActLoopNT-out 10.8682 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.11, 136.4 APE9-dihe-na -65.57, -21.76 APE8-dihe-out -71.02, -4.43 APE8-rot-out 44.37 APE67-dihe-in -63.83, -21.68 -115.56, -21.67 APE12-dist-out 21.944 APE11-dist-out 23.7604 APE10-dist-out 17.9214 APE9-dist-out 11.3284 None None None XRAY 1.65 0.181 0.194 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r8z Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R97A P47811 5 352 360.0 RUY:401 Type3 Inactive DFGin 8.0523 16.7857 BLBminus -107.35, 174.0 88.72, 75.58 -129.06, 130.07 292.0, 84.81 76.81, 15.71 in-in in 9.1352 Saltbr-in 2.8616 HRD-in -73.91, -50.02 78.62, -14.33 in-out-out SNCioo out-out ActLoopNT-out 11.0059 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.66, 133.31 APE9-dihe-na -61.73, -24.21 APE8-dihe-out -70.48, -5.0 APE8-rot-out 35.58 APE67-dihe-in -62.43, -22.92 -114.02, -22.54 APE12-dist-out 21.9711 APE11-dist-out 23.7783 APE10-dist-out 17.9284 APE9-dist-out 11.3993 None None None XRAY 1.438 0.178 0.187 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r97 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9DA P47811 5 352 360.0 N9J:401 Type3 Inactive DFGin 6.9061 16.2906 BLBminus -142.84, -177.62 59.46, 54.53 -49.92, 143.22 293.02, 81.79 -67.58, 124.55 in-in in 9.6071 Saltbr-in 2.7075 HRD-in -71.3, -52.07 83.51, -18.96 in-out-out SNCioo out-out ActLoopNT-out 10.6598 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.54, 137.09 APE9-dihe-na -66.35, -15.51 APE8-dihe-out -64.24, -16.61 APE8-rot-out 49.12 APE67-dihe-in -64.38, -19.38 -115.02, -18.09 APE12-dist-out 21.6518 APE11-dist-out 23.9196 APE10-dist-out 18.2348 APE9-dist-out 11.8414 None None None XRAY 1.69 0.192 0.213 A 360.0 344.0 4 25 25 0 [[24, 308]] 1.0 5r9d Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9EA P47811 5 352 360.0 S7S:401 Type3 Inactive DFGin 7.6744 17.2716 BLBminus -137.39, 179.1 57.74, 56.07 -53.7, 142.45 286.41, 71.06 -68.12, 115.34 in-in in 9.9193 Saltbr-in 2.8383 HRD-in -69.03, -54.62 82.77, -10.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.87, 136.52 APE9-dihe-na -64.45, -18.37 APE8-dihe-out -63.84, -12.84 APE8-rot-out 48.2 APE67-dihe-in -64.03, -22.32 -118.18, -18.76 APE12-dist-out 22.0535 APE11-dist-out 24.2243 APE10-dist-out 18.501 APE9-dist-out 11.8396 None None None XRAY 1.775 0.192 0.212 A 360.0 345.0 3 25 24 1 [[24, 308]] 1.0 5r9e Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9KA P47811 4 352 360.0 SR4:401 Type3 Inactive DFGin 7.9752 16.6643 BLBminus -109.17, 173.51 89.46, 74.18 -129.95, 129.84 290.88, 85.94 81.01, 12.12 in-in in 9.27 Saltbr-in 2.8652 HRD-in -71.68, -50.3 79.29, -13.82 in-out-out SNCioo out-out ActLoopNT-out 10.7713 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.69, 132.06 APE9-dihe-na -61.92, -24.83 APE8-dihe-out -67.69, -6.53 APE8-rot-out 49.1 APE67-dihe-in -65.36, -21.0 -113.73, -21.26 APE12-dist-out 21.8145 APE11-dist-out 23.6535 APE10-dist-out 17.818 APE9-dist-out 11.3684 None None None XRAY 1.498 0.19 0.201 A 360.0 343.0 6 25 25 0 [[24, 308]] 1.0 5r9k Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9QA P47811 5 352 360.0 LVD:401 Type3 Inactive DFGin 8.1877 17.0637 BLBminus -112.14, 170.23 80.58, 82.07 -125.39, 129.02 290.8, 89.76 79.27, 13.12 in-in in 9.66 Saltbr-in 2.7687 HRD-in -79.07, -52.75 78.49, -13.32 in-out-out SNCioo out-out ActLoopNT-out 11.7684 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 130.81 APE9-dihe-na -62.18, -18.13 APE8-dihe-out -61.69, -16.69 APE8-rot-out 55.26 APE67-dihe-in -64.61, -20.41 -115.23, -19.01 APE12-dist-out 21.8683 APE11-dist-out 23.655 APE10-dist-out 17.8123 APE9-dist-out 11.6255 None None None XRAY 1.645 0.211 0.229 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r9q Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9WA P47811 5 352 360.0 STV:401 Type3 Inactive DFGin 7.6564 16.9506 BLBminus -134.85, -175.6 55.42, 59.11 -52.2, 138.85 288.54, 71.33 -68.06, 113.57 in-in in 9.773 Saltbr-in 2.8469 HRD-in -67.37, -56.08 84.96, -12.7 in-out-out SNCioo out-out ActLoopNT-out 10.0754 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.6, 135.98 APE9-dihe-na -66.18, -24.11 APE8-dihe-out -59.13, -22.75 APE8-rot-out 55.31 APE67-dihe-in -66.54, -23.46 -107.25, -17.91 APE12-dist-out 22.2417 APE11-dist-out 24.4104 APE10-dist-out 18.6084 APE9-dist-out 11.7572 None None None XRAY 1.89 0.176 0.204 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9w Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA1A P47811 5 352 360.0 PO6:401 Type3 Inactive DFGin 8.0317 16.9673 BLBminus -116.6, 170.37 81.52, 81.7 -127.11, 124.0 290.13, 89.2 75.77, 17.38 in-in in 9.5985 Saltbr-in 2.7673 HRD-in -67.99, -54.24 81.95, -19.51 in-out-out SNCioo out-out ActLoopNT-out 11.3297 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 131.95 APE9-dihe-na -63.72, -22.68 APE8-dihe-out -62.28, -13.71 APE8-rot-out 51.04 APE67-dihe-in -62.19, -23.02 -116.68, -25.26 APE12-dist-out 21.9817 APE11-dist-out 23.8091 APE10-dist-out 17.9257 APE9-dist-out 11.4782 None None None XRAY 1.61 0.188 0.213 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra1 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA9A P47811 5 352 360.0 SWD:401 Type3 Inactive DFGin 7.838 16.6064 BLBminus -112.11, 165.99 91.45, 84.17 -130.08, 120.06 293.76, 89.11 79.19, 18.98 in-in in 9.4222 Saltbr-in 3.02 HRD-in -67.29, -51.81 76.3, -9.73 in-out-out SNCioo out-out ActLoopNT-out 11.0523 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.19, 133.7 APE9-dihe-na -64.27, -25.04 APE8-dihe-out -60.75, -16.06 APE8-rot-out 55.77 APE67-dihe-in -64.26, -22.13 -114.22, -21.12 APE12-dist-out 21.9486 APE11-dist-out 23.8109 APE10-dist-out 17.9369 APE9-dist-out 11.5975 None None None XRAY 1.68 0.185 0.201 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra9 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7Z9TBBB P47811 4 353 360.0 87B:401,ATP:402 Type3,Allosteric Inactive DFGin 5.8293 15.2444 BLBminus -103.34, -178.81 25.47, 89.69 -68.87, -161.65 315.54, 109.9 -76.7, 116.65 out-out out 10.3417 Saltbr-out 4.1791 HRD-in -67.82, -70.27 93.09, -17.91 out-out-out SNCooo out-out ActLoopNT-out 7.706 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -124.01, -67.71 APE9-dihe-na -98.04, -13.3 APE8-dihe-out -67.58, -39.12 APE8-rot-in 311.0 APE67-dihe-in -63.55, -21.3 -74.81, -8.77 APE12-dist-out 14.5958 APE11-dist-out 16.3559 APE10-dist-out 19.3522 APE9-dist-out 12.5383 None None None XRAY 2.6 0.202 0.254 BBB 359.0 350.0 0 25 25 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7ZA P47811 5 359 360.0 OG2:401,SB4:402 Allosteric,Type1 Inactive DFGin 5.8047 14.0802 BLBplus -134.49, 165.73 62.07, 30.36 -82.63, 160.92 45.56, 91.95 67.74, 16.55 in-in in 9.0911 Saltbr-in 2.6363 HRD-in -77.23, -57.59 79.7, -16.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -109.25, 119.36 APE9-dihe-na -93.25, 151.32 APE8-dihe-in -67.43, 140.14 APE8-rot-in 312.96 APE67-dihe-in -62.55, -20.7 -109.35, 3.64 APE12-dist-none 999.0 APE11-dist-out 14.3829 APE10-dist-out 17.8776 APE9-dist-out 10.7115 C162S None None XRAY 1.35 0.206 0.221 A 360.0 345.0 10 25 15 10 [[24, 308]] 1.0 6y7z Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y80A P47811 5 359 360.0 OFZ:401,SB4:402 Allosteric,Type1 Inactive DFGin 5.7992 14.0377 BLBplus -138.73, 168.62 61.09, 29.77 -83.59, 159.45 46.06, 90.54 66.98, 15.27 in-in in 9.087 Saltbr-in 2.665 HRD-in -74.85, -59.95 82.11, -13.42 in-out-out SNCioo out-out ActLoopNT-out 9.6978 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -117.02, 118.3 APE9-dihe-na -92.88, 152.22 APE8-dihe-in -67.79, 140.44 APE8-rot-in 312.07 APE67-dihe-in -64.09, -20.28 -111.17, 5.5 APE12-dist-none 999.0 APE11-dist-out 14.1846 APE10-dist-out 17.7618 APE9-dist-out 10.6436 C162S None None XRAY 1.24 0.211 0.225 A 360.0 347.0 8 25 17 8 [[24, 308]] 1.0 6y80 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y85A P47811 5 359 360.0 OG8:401,SB4:402 Allosteric,Type1 Inactive DFGin 5.7885 14.0002 BLBplus -133.77, 163.81 63.67, 30.98 -81.27, 159.22 44.79, 91.89 66.91, 14.74 in-in in 9.1062 Saltbr-in 2.6334 HRD-in -79.67, -55.49 77.93, -17.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 122.52 APE9-dihe-na -99.2, 150.85 APE8-dihe-in -73.53, 136.09 APE8-rot-out 184.17 APE67-dihe-in -61.9, -19.08 -104.49, 5.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.7913 APE9-dist-out 10.7698 C162S None None XRAY 1.58 0.203 0.233 A 360.0 344.0 11 25 14 11 [[24, 308]] 1.0 6y85 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1YWRA P47811 5 352 360.0 LI9:361 Type1 Inactive DFGin 5.2108 13.9496 BLBplus -116.71, 157.04 59.91, 27.05 -73.95, 150.06 44.11, 88.12 64.26, 12.6 in-in in 9.1159 Saltbr-in 2.8598 HRD-in -70.15, -61.76 83.18, -15.96 in-out-out SNCioo out-out ActLoopNT-out 6.7427 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -48.34 APE9-dihe-na -66.85, 129.84 APE8-dihe-out -48.26, -56.45 APE8-rot-in 267.39 APE67-dihe-in -58.06, -30.9 -49.13, -36.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.5909 APE9-dist-out 11.2889 T180A,Y182F None None XRAY 1.95 0.221 999.0 A 360.0 338.0 10 25 16 9 [[24, 308]] 1.0 1ywr Mus musculus CMGC_MAPK14_MOUSE CMGC 5.7e-84 287.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GHLA P47811 5 352 360.0 LIB:401 Type1 Inactive DFGin 5.9959 13.5411 BLBplus -97.83, 160.0 59.37, 11.56 -48.09, 172.67 29.98, 90.0 61.12, 163.68 in-in in 9.1546 Saltbr-in 2.7617 HRD-in -68.51, -51.08 75.63, -16.1 in-out-out SNCioo out-out ActLoopNT-out 7.3922 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.45 APE8-dihe-out -59.27, -35.78 APE8-rot-in 257.99 APE67-dihe-in -62.7, -29.84 -59.27, -22.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0703 T180A,Y182F None None XRAY 2.099 0.22 0.301 A 348.0 334.0 14 25 15 10 [[24, 308]] 1.0 2ghl Mus musculus CMGC_MAPK14_MOUSE CMGC 6.3e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7PVUB P47811 5 353 360.0 8DI:401 Type1 Inactive DFGin 4.7753 13.4884 BLBplus -105.43, 149.04 51.46, 91.1 -127.89, 139.29 40.85, 75.02 77.85, 16.27 in-out in 9.3171 Saltbr-out 4.8669 HRD-in -70.68, -50.64 86.9, -39.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.21, -24.31 999.0, -41.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.154 0.207 0.239 B 359.0 336.0 13 25 12 13 [[24, 308]] 1.0 7pvu Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y8HA P47811 6 359 360.0 SB4:401 Type1 Inactive DFGin 5.8151 14.0537 BLBplus -135.21, 165.85 62.02, 30.41 -83.55, 158.25 44.85, 92.38 64.97, 19.96 in-in in 9.072 Saltbr-in 2.6287 HRD-in -77.67, -57.36 79.23, -15.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -117.79, 112.37 APE9-dihe-na -86.44, 149.11 APE8-dihe-in -71.62, 140.44 APE8-rot-out 186.93 APE67-dihe-in -64.36, -20.23 -106.31, 4.54 APE12-dist-none 999.0 APE11-dist-out 14.2864 APE10-dist-out 17.8292 APE9-dist-out 10.6582 C162S None None XRAY 1.37 0.22 0.24 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6y8h Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8ACMAAA P47811 4 353 360.0 SB2:404 Type1 Inactive DFGin 4.9736 13.5759 BLBplus -133.06, 172.45 65.93, 40.39 -104.24, 158.57 46.44, 78.55 74.47, 13.2 in-in in 9.2831 Saltbr-in 2.733 HRD-in -64.79, -58.1 86.27, -19.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -80.81 APE8-rot-out 32.52 APE67-dihe-in -67.54, -28.38 -107.69, -1.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.203 0.244 AAA 359.0 337.0 13 25 12 13 [[24, 308]] 1.0 8acm Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOOA P47811 5 353 360.0 SB4:401 Type1 Inactive DFGin 5.1652 13.6397 BLBplus -138.69, 175.26 57.38, 21.13 -65.41, 148.91 40.93, 100.05 58.84, 14.22 in-in in 9.4468 Saltbr-in 2.7407 HRD-in -67.27, -58.36 82.42, -11.86 in-out-out SNCioo out-out ActLoopNT-out 7.805 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -69.7, -42.51 APE9-dihe-na -65.22, -44.97 APE8-dihe-out -51.84, -47.66 APE8-rot-in 295.05 APE67-dihe-in -57.54, -26.2 -56.34, -38.54 APE12-dist-in 13.22 APE11-dist-out 14.0915 APE10-dist-out 18.2412 APE9-dist-out 10.5624 None None None XRAY 1.95 0.241 0.25 A 361.0 349.0 0 25 25 0 [[24, 308]] 1.0 4loo Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPA P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 4.9871 13.5854 BLBplus -129.95, 174.57 59.37, 38.27 -78.72, 134.12 36.97, 91.41 61.45, 25.3 in-in in 9.3588 Saltbr-in 2.6652 HRD-in -71.62, -51.29 83.15, -21.15 in-out-out SNCioo out-out ActLoopNT-out 9.2801 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.82, -52.38 APE9-dihe-na -68.84, -35.89 APE8-dihe-out -58.52, -41.68 APE8-rot-in 287.8 APE67-dihe-in -57.4, -27.72 -51.64, -45.15 APE12-dist-in 12.9714 APE11-dist-out 14.1938 APE10-dist-out 18.3542 APE9-dist-out 10.6314 None None None XRAY 2.049 0.228 0.188 A 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPD P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 5.2292 13.7485 BLBplus -121.46, 170.78 65.92, 32.28 -73.43, 136.83 36.96, 89.29 68.77, 15.79 in-in in 9.3311 Saltbr-in 2.3969 HRD-in -63.28, -51.2 80.67, -15.6 in-out-out SNCioo out-out ActLoopNT-out 9.0273 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -67.14, -56.19 APE9-dihe-na -62.79, -36.04 APE8-dihe-out -60.71, -35.02 APE8-rot-in 289.55 APE67-dihe-in -68.29, -24.83 -59.29, -35.33 APE12-dist-in 13.1326 APE11-dist-out 14.63 APE10-dist-out 18.7219 APE9-dist-out 10.6414 None None None XRAY 2.049 0.228 0.188 D 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5O90A P47811 5 353 360.0 SB4:60401 Type1 Inactive DFGin 5.4528 13.7859 BLBplus -138.77, 169.02 69.52, 19.52 -71.52, 150.78 44.44, 88.51 66.51, 10.19 in-in in 8.9964 Saltbr-in 2.1227 HRD-in -58.31, -66.83 71.21, -2.15 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nooo APE10-dihe-na -66.12, -47.79 APE9-dihe-na -59.74, -42.18 APE8-dihe-out -59.22, -24.24 APE8-rot-none 999.0 APE67-dihe-in -69.19, -25.86 -58.58, -27.59 APE12-dist-none 999.0 APE11-dist-out 14.1867 APE10-dist-out 18.6192 APE9-dist-out 11.8699 T185G None None XRAY 2.49 0.25 0.275 A 360.0 330.0 19 25 16 9 [[24, 308]] 1.0 5o90 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.8e-84 288.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7WA P47811 6 359 360.0 SB4:401,OFW:407 Type1,Allosteric Inactive DFGin 5.7758 14.0012 BLBplus -138.18, 164.68 62.81, 30.03 -82.32, 159.35 44.93, 92.43 65.05, 18.06 in-in in 9.078 Saltbr-in 2.7148 HRD-in -76.23, -57.75 79.93, -16.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -109.65, 120.06 APE9-dihe-na -93.91, 149.55 APE8-dihe-in -73.55, 137.64 APE8-rot-out 186.72 APE67-dihe-in -61.54, -21.24 -103.29, -0.91 APE12-dist-none 999.0 APE11-dist-out 14.1674 APE10-dist-out 17.7506 APE9-dist-out 10.6882 C162S None None XRAY 1.39 0.196 0.219 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6y7w Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7XA P47811 5 359 360.0 SB4:401,OFQ:407 Type1,Allosteric Inactive DFGin 5.8376 14.1423 BLBplus -140.52, 171.9 59.02, 32.21 -87.93, 160.25 46.31, 91.31 62.16, 18.97 in-in in 9.0815 Saltbr-in 2.6196 HRD-in -74.68, -57.27 79.25, -15.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -117.66, 121.28 APE9-dihe-na -97.49, 147.27 APE8-dihe-in -70.48, 139.23 APE8-rot-out 189.8 APE67-dihe-in -64.63, -20.63 -107.94, 3.51 APE12-dist-none 999.0 APE11-dist-out 14.2773 APE10-dist-out 17.7869 APE9-dist-out 10.699 C162S None None XRAY 1.45 0.211 0.229 A 360.0 345.0 10 25 15 10 [[24, 308]] 1.0 6y7x Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y81A P47811 6 359 360.0 SB4:401,OG5:412 Type1,Allosteric Inactive DFGin 5.7123 14.0382 BLBplus -134.64, 167.76 60.96, 33.88 -85.35, 157.58 46.03, 92.46 64.9, 14.25 in-in in 9.057 Saltbr-in 2.65 HRD-in -76.57, -56.48 79.55, -12.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -115.04, 120.9 APE9-dihe-na -94.31, 149.4 APE8-dihe-in -73.15, 140.45 APE8-rot-out 187.1 APE67-dihe-in -64.15, -19.25 -104.4, 0.89 APE12-dist-none 999.0 APE11-dist-out 14.4174 APE10-dist-out 17.8789 APE9-dist-out 10.73 C162S None None XRAY 1.54 0.196 0.216 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6y81 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y82A P47811 6 360 360.0 SB4:401,308:406 Type1,Allosteric Inactive DFGin 5.7802 14.1165 BLBplus -142.47, 171.91 59.75, 34.72 -91.59, 158.86 46.33, 90.48 63.9, 13.45 in-in in 9.0992 Saltbr-in 2.6025 HRD-in -74.39, -55.41 79.48, -17.19 in-out-out SNCioo out-out ActLoopNT-out 10.0125 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -118.57, 115.69 APE9-dihe-na -92.25, 152.14 APE8-dihe-in -74.19, 138.56 APE8-rot-out 188.04 APE67-dihe-in -61.96, -21.6 -107.94, 4.31 APE12-dist-none 999.0 APE11-dist-out 14.3499 APE10-dist-out 17.8896 APE9-dist-out 10.7463 C162S None None XRAY 1.44 0.217 0.243 A 360.0 348.0 7 25 18 7 [[24, 308]] 1.0 6y82 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YCWA P47811 6 359 360.0 SB4:401,OL8:405 Type1,Allosteric Inactive DFGin 5.709 13.9783 BLBplus -139.04, 169.42 60.88, 31.24 -83.97, 157.96 42.66, 93.01 65.82, 20.88 in-in in 9.0477 Saltbr-in 2.7268 HRD-in -76.03, -57.42 78.87, -15.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -117.62, 117.38 APE9-dihe-na -94.12, 150.56 APE8-dihe-in -63.64, 137.82 APE8-rot-in 296.65 APE67-dihe-in -63.75, -20.54 -110.36, 3.6 APE12-dist-none 999.0 APE11-dist-out 14.2316 APE10-dist-out 17.7539 APE9-dist-out 10.6885 C162S None None XRAY 1.34 0.23 0.251 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6ycw Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOVA P47811 6 359 360.0 SB4:401,LOT:406,LOW:407 Type1,Allosteric,Allosteric Inactive DFGin 5.7849 14.0824 BLBplus -138.85, 169.33 61.87, 30.79 -84.92, 158.4 45.37, 91.9 65.06, 17.43 in-in in 9.109 Saltbr-in 2.6841 HRD-in -76.78, -56.48 78.7, -16.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -119.14, 115.02 APE9-dihe-na -91.52, 150.5 APE8-dihe-in -73.47, 137.08 APE8-rot-out 187.92 APE67-dihe-in -63.35, -21.25 -104.06, 1.09 APE12-dist-none 999.0 APE11-dist-out 14.2686 APE10-dist-out 17.8733 APE9-dist-out 10.6949 None None None XRAY 1.31 0.222 0.236 A 361.0 345.0 9 25 16 9 [[24, 308]] 1.0 6sov Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SP9A P47811 5 359 360.0 SB4:401,LOT:407,LOT:408 Type1,Allosteric,Allosteric Inactive DFGin 5.7449 14.0248 BLBplus -140.9, 168.52 62.86, 31.59 -87.26, 153.1 44.44, 90.21 64.02, 999.0 in-in in 9.1125 Saltbr-in 2.6859 HRD-in -74.78, -57.56 80.54, -13.75 in-out-out SNCioo out-out ActLoopNT-out 10.2704 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -121.16, 112.82 APE9-dihe-na -87.42, 149.28 APE8-dihe-in -72.91, 139.05 APE8-rot-out 186.67 APE67-dihe-in -63.91, -20.89 -106.74, 1.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6765 None None None XRAY 1.22 0.221 0.235 A 361.0 348.0 7 25 18 7 [[24, 308]] 1.0 6sp9 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7YA P47811 6 359 360.0 SB4:401,OFQ:407,LOT:408,LOT:409 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 5.5985 14.0658 BLBplus -134.15, 167.21 61.56, 33.57 -84.2, 154.3 46.03, 91.51 71.1, 10.08 in-in in 9.0829 Saltbr-in 2.4631 HRD-in -77.03, -55.9 76.47, -10.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 124.77 APE9-dihe-na -96.71, 148.3 APE8-dihe-in -61.68, 139.31 APE8-rot-in 301.71 APE67-dihe-in -65.13, -20.59 -107.51, 1.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.6132 APE9-dist-out 10.7375 C162S None None XRAY 1.51 0.221 0.248 A 360.0 343.0 11 25 14 11 [[24, 308]] 1.0 6y7y Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SPLA P47811 6 359 360.0 SB4:401,LOW:407,LOW:408,LOW:409 Type1,Allosteric,Type1,Allosteric Inactive DFGin 5.7888 14.0854 BLBplus -138.3, 168.28 62.33, 31.95 -86.41, 154.5 45.54, 89.73 64.4, 18.17 in-in in 9.0762 Saltbr-in 2.6411 HRD-in -75.83, -58.19 80.85, -15.09 in-out-out SNCioo out-out ActLoopNT-out 9.5477 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -119.05, 110.89 APE9-dihe-na -86.15, 150.38 APE8-dihe-in -72.29, 139.09 APE8-rot-out 187.06 APE67-dihe-in -62.58, -21.12 -105.6, 1.04 APE12-dist-none 999.0 APE11-dist-out 14.3304 APE10-dist-out 17.9596 APE9-dist-out 10.672 None None None XRAY 1.38 0.212 0.225 A 361.0 345.0 9 25 16 9 [[24, 308]] 1.0 6spl Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7Z6IAAA P47811 5 354 360.0 IIM:401,87B:402 Type1,Type1 Inactive DFGin 5.0264 13.1011 BLBplus -131.93, 169.42 64.34, 26.47 -80.75, 150.18 38.76, 73.8 75.32, 1.38 in-in in 9.0659 Saltbr-in 2.8167 HRD-in -67.36, -56.38 84.82, -19.96 in-out-out SNCioo out-out ActLoopNT-out 7.604 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -134.34, 166.34 APE9-dihe-na 72.42, 10.47 APE8-dihe-out -100.2, -17.45 APE8-rot-out 95.44 APE67-dihe-in -59.29, -28.51 -61.84, -26.86 APE12-dist-out 14.4451 APE11-dist-in 12.4653 APE10-dist-out 17.6048 APE9-dist-out 11.8602 C162S None None XRAY 2.25 0.195 0.248 AAA 360.0 350.0 0 25 25 0 [[24, 308]] 1.0 7z6i Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOUA P47811 5 352 360.0 LPZ:406,LPZ:407 Allosteric,Type1 Inactive DFGin 7.3625 16.8084 None -133.04, -176.46 59.36, 52.66 -52.08, 999.0 288.27, 77.53 999.0, 999.0 in-in in 9.7302 Saltbr-in 2.8273 HRD-in -72.19, -51.58 83.69, -12.25 in-out-out SNCioo out-out ActLoopNT-out 12.0028 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.59, 133.82 APE9-dihe-na -63.41, -18.88 APE8-dihe-out -63.42, -15.13 APE8-rot-out 53.27 APE67-dihe-in -66.48, -19.16 -115.28, -17.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8872 None None None XRAY 1.5 0.216 0.233 A 381.0 342.0 6 25 22 3 [[24, 308]] 1.0 6sou Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3TG1A P47811 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8247 16.0345 None -116.32, 155.59 -1.61, 110.61 -70.76, 999.0 331.08, 173.37 999.0, 999.0 in-in in 9.7774 Saltbr-in 3.192 HRD-in -71.22, -51.39 75.49, -16.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.05 APE8-dihe-out -54.64, -33.8 APE8-rot-out 159.97 APE67-dihe-in -72.3, -17.1 -60.98, -22.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2156 None None None XRAY 2.71 0.311 0.26 A 380.0 334.0 14 25 11 14 [[24, 308]] 1.0 3tg1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GHMA P47811 5 352 360.0 LIC:353 Type1 Inactive DFGin 5.7845 13.7767 None -78.81, 171.19 -55.87, 93.41 -25.52, 88.72 34.83, 93.47 -170.14, 167.5 in-in in 9.288 Saltbr-in 3.2035 HRD-in -62.78, -61.35 90.75, -25.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -53.87 APE9-dihe-na -71.96, -67.71 APE8-dihe-out -49.26, -48.1 APE8-rot-in 270.21 APE67-dihe-in -62.91, -14.17 -44.49, -46.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.3212 APE9-dist-out 11.3867 T180A,Y182F None None XRAY 2.35 0.232 0.323 A 348.0 336.0 12 25 14 11 [[24, 308]] 1.0 2ghm Mus musculus CMGC_MAPK14_MOUSE CMGC 6.3e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1YW2A P47811 4 353 360.0 PGJ:62001 Type1 Inactive DFGin 7.4408 13.8889 None -108.87, 130.98 -78.03, -31.11 -137.46, 121.59 317.27, 85.69 -153.54, 999.0 in-in in 9.1653 Saltbr-in 2.8889 HRD-in -65.03, -58.53 71.57, -11.34 in-out-out SNCioo out-out ActLoopNT-out 19.2412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 140.08 APE9-dihe-na -171.64, 79.36 APE8-dihe-out -4.97, -52.19 APE8-rot-out 22.63 APE67-dihe-in -78.16, -22.44 -73.05, -7.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3444 T180A,Y182F None None XRAY 2.01 0.207 0.29 A 360.0 341.0 9 25 16 9 [[24, 308]] 1.0 1yw2 Mus musculus CMGC_MAPK14_MOUSE CMGC 7.1e-84 287.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GTMA P47811 5 352 360.0 LID:353 Type1 Inactive DFGin 10.5798 12.2976 None -99.42, 151.2 -66.85, -46.24 -140.98, 139.16 303.6, 104.59 -99.33, -162.53 in-in in 9.0195 Saltbr-in 2.6326 HRD-in -70.94, -57.65 84.88, -6.9 in-out-out SNCioo out-out ActLoopNT-out 21.3254 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -146.35, 106.63 APE9-dihe-na -84.71, 129.28 APE8-dihe-out -45.44, -51.38 APE8-rot-in 285.81 APE67-dihe-in -54.42, -30.85 -58.09, -32.0 APE12-dist-none 999.0 APE11-dist-in 10.9379 APE10-dist-out 9.1615 APE9-dist-out 10.8018 None None None XRAY 1.9 0.231 0.261 A 348.0 341.0 7 25 21 4 [[24, 308]] 1.0 2gtm Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GTNA P47811 5 352 360.0 LIE:354 Type1 Inactive DFGin 10.5589 12.1049 None -97.49, 148.4 -66.36, -50.18 -132.83, 140.82 310.6, 94.93 -102.32, -165.42 in-in in 8.8869 Saltbr-in 2.5937 HRD-in -68.82, -53.97 78.95, -12.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.88 APE8-dihe-out -46.6, -50.56 APE8-rot-in 275.26 APE67-dihe-in -60.86, -30.99 -59.17, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8082 None None None XRAY 1.8 0.203 0.248 A 348.0 337.0 11 25 14 11 [[24, 308]] 1.0 2gtn Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8ACOAAA P47811 4 352 360.0 SB2:401 Type1 Inactive DFGin 5.7374 14.0092 None -148.97, 178.49 24.89, 96.95 -83.03, 999.0 316.51, 111.13 999.0, 999.0 in-in in 9.3324 Saltbr-in 2.582 HRD-in -68.93, -56.93 87.8, -49.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -122.76 APE8-rot-in 323.22 APE67-dihe-in -64.13, -36.89 -112.86, 8.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.212 0.278 AAA 359.0 334.0 15 25 10 15 [[24, 308]] 1.0 8aco Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9UA P47811 5 352 360.0 JMM:401 Type1 Inactive DFGin 7.8704 16.4146 None -105.42, 167.68 86.02, 81.87 -120.77, 999.0 293.85, 91.32 999.0, 999.0 in-in in 9.5521 Saltbr-in 2.9149 HRD-in -68.92, -55.3 81.59, -7.51 in-out-out SNCioo out-out ActLoopNT-out 10.0022 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -133.83, 134.83 APE9-dihe-na -63.75, -21.85 APE8-dihe-out -58.31, -17.35 APE8-rot-out 54.12 APE67-dihe-in -65.05, -20.74 -118.93, -19.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6787 None None None XRAY 1.67 0.187 0.213 A 360.0 345.0 3 25 22 3 [[24, 308]] 1.0 5r9u Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8EFJA P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.6842 15.1508 None -107.83, -138.53 -47.2, 131.52 -82.89, 153.62 283.8, 59.38 -72.43, 123.55 in-in in 9.147 Saltbr-in 2.8713 HRD-in -63.56, -52.6 86.58, -8.43 in-out-out SNCioo out-out ActLoopNT-out 9.1047 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -48.45 APE9-dihe-na -142.16, 106.07 APE8-dihe-in -57.79, 138.19 APE8-rot-out 182.41 APE67-dihe-in -58.85, -41.56 -95.36, -2.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.8627 APE9-dist-out 9.537 None None None XRAY 2.31 0.193 0.223 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8efj Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VMHA P47811 5 354 360.0 A1ACT:603 Type1 Inactive DFGin 10.8876 12.6554 None -91.57, 155.22 -78.87, -42.97 -134.13, 132.21 306.13, 106.97 -93.28, -173.32 in-in in 9.1199 Saltbr-in 2.4999 HRD-in -70.23, -50.72 73.72, -8.99 in-out-out SNCioo out-out ActLoopNT-out 21.4911 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 65.99 APE9-dihe-na -65.29, 141.53 APE8-dihe-out -65.65, -35.56 APE8-rot-in 296.74 APE67-dihe-in -54.93, -23.21 -63.02, -29.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7755 APE9-dist-out 11.8061 None None None XRAY 2.46 0.21 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmh Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.9836 13.1585 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.4266 Saltbr-in 2.5383 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.1108 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5031 APE9-dist-out 11.8253 None None None XRAY 2.4 0.207 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VT6A P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.7293 15.1507 None -106.7, -137.28 -49.07, 131.85 -82.77, 153.72 284.07, 57.8 -72.41, 123.53 in-in in 9.1741 Saltbr-in 2.5587 HRD-in -64.24, -49.87 82.02, -7.33 in-out-out SNCioo out-out ActLoopNT-out 9.1157 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -58.08 APE9-dihe-na -131.51, 108.06 APE8-dihe-in -61.02, 149.49 APE8-rot-out 183.06 APE67-dihe-in -60.32, -29.4 -95.05, -11.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.7558 APE9-dist-out 9.4982 None None None XRAY 2.31 0.166 0.216 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vt6 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VWMA P47811 5 360 360.0 WHE:401 Type1 Inactive DFGin 6.7659 15.2325 None -105.37, -136.33 -48.31, 132.67 -83.1, 152.37 281.96, 61.27 -72.7, 123.36 in-in in 9.177 Saltbr-in 2.8721 HRD-in -65.49, -53.48 85.5, -8.91 in-out-out SNCioo out-out ActLoopNT-out 9.1811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -44.6 APE9-dihe-na -141.61, 100.51 APE8-dihe-in -61.36, 142.62 APE8-rot-out 185.47 APE67-dihe-in -63.84, -26.29 -92.21, -4.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.0139 APE9-dist-out 9.637 None None None XRAY 1.94 0.177 0.222 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vwm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2EWAA P47811 5 354 360.0 SB2:361 Type1 Inactive DFGin 6.575 15.1465 None -155.19, 179.59 -144.72, 110.73 -99.77, 145.73 66.01, 43.3 59.16, 999.0 in-in in 9.4738 Saltbr-in 2.6977 HRD-in -67.14, -51.92 76.56, -18.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -36.62 APE8-rot-in 319.01 APE67-dihe-in -54.41, -29.01 -77.11, -17.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.241 0.279 A 379.0 330.0 20 25 11 14 [[24, 308]] 1.0 2ewa Mus musculus CMGC_MAPK14_MOUSE CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YCUA P47811 6 359 360.0 SB4:401,OKZ:405 Type1,Allosteric Inactive DFGin 6.0979 14.3679 None -143.57, 175.48 60.18, 42.46 -110.51, 999.0 50.6, 83.02 999.0, 999.0 in-in in 9.1165 Saltbr-in 2.6532 HRD-in -71.9, -56.23 80.62, -14.35 in-out-out SNCioo out-out ActLoopNT-out 10.3489 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -118.54, 114.44 APE9-dihe-na -89.96, 150.08 APE8-dihe-in -65.08, 137.29 APE8-rot-in 294.76 APE67-dihe-in -63.71, -21.71 -110.97, 4.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7014 C162S None None XRAY 1.35 0.232 0.253 A 360.0 347.0 7 25 18 7 [[24, 308]] 1.0 6ycu Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5LARA P47811 4 353 360.0 6SH:401 Type2 Inactive DFGout 13.2905 10.4387 BBAminus -133.45, 176.6 -138.75, 105.58 -80.2, 0.76 291.45, 119.23 -103.68, -156.87 in-in in 9.0889 Saltbr-in 2.6691 HRD-in -69.38, -53.28 78.67, -10.79 in-out-out SNCioo out-out ActLoopNT-out 6.2083 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -150.44, 132.72 APE9-dihe-na -75.03, -47.05 APE8-dihe-in -134.28, 144.41 APE8-rot-out 176.96 APE67-dihe-in -65.62, -17.84 -109.49, 11.38 APE12-dist-in 11.0929 APE11-dist-in 8.925 APE10-dist-out 10.7829 APE9-dist-out 10.3035 None None None XRAY 1.5 0.171 0.205 A 361.0 350.0 0 25 25 0 [[24, 308]] 1.0 5lar Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4TA P47811 5 355 360.0 O8W:401 Type2 Inactive DFGout 13.3955 10.3789 BBAminus -144.71, -175.5 -142.03, 108.93 -81.5, -11.12 288.34, 120.37 77.48, -158.94 in-in in 9.3967 Saltbr-in 2.6808 HRD-in -65.74, -56.2 76.93, -24.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -102.36, 110.44 APE9-dihe-na -74.04, 131.72 APE8-dihe-out -46.21, -42.69 APE8-rot-in 287.63 APE67-dihe-in -64.67, -21.68 -58.48, -29.87 APE12-dist-none 999.0 APE11-dist-in 12.8491 APE10-dist-out 12.0006 APE9-dist-out 10.7269 None None None XRAY 1.98 0.201 0.251 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6y4t Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4UA P47811 5 355 360.0 O98:401 Type2 Inactive DFGout 13.5343 10.6091 BBAminus -141.86, -178.12 -140.97, 108.08 -77.71, -12.1 292.53, 118.95 71.89, -159.26 in-in in 9.2937 Saltbr-in 2.8004 HRD-in -69.64, -57.74 78.32, -9.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -81.39, 107.52 APE9-dihe-na -71.81, 133.12 APE8-dihe-out -54.21, -39.99 APE8-rot-in 289.32 APE67-dihe-in -64.78, -22.51 -60.96, -27.38 APE12-dist-none 999.0 APE11-dist-in 12.0152 APE10-dist-out 11.4107 APE9-dist-out 10.7477 None None None XRAY 1.86 0.192 0.241 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6y4u Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4VA P47811 5 355 360.0 O8Z:401 Type2 Inactive DFGout 13.4787 10.4527 BBAminus -139.41, -176.58 -143.81, 106.57 -80.04, -18.49 283.79, 123.68 78.51, -150.94 in-in in 9.437 Saltbr-in 2.9224 HRD-in -69.56, -58.59 79.18, -11.72 in-out-out SNCioo out-out ActLoopNT-out 20.851 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -103.51, 114.79 APE9-dihe-na -77.81, 122.67 APE8-dihe-out -48.41, -38.41 APE8-rot-in 303.02 APE67-dihe-in -59.86, -25.31 -52.21, -36.63 APE12-dist-none 999.0 APE11-dist-in 10.5606 APE10-dist-out 11.6414 APE9-dist-out 10.6746 None None None XRAY 1.75 0.191 0.222 A 361.0 343.0 8 25 17 8 [[24, 308]] 1.0 6y4v Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4WA P47811 5 355 360.0 O8T:401 Type2 Inactive DFGout 13.4391 10.5955 BBAminus -140.93, -175.05 -144.74, 105.28 -75.89, -17.02 288.84, 121.29 74.94, -159.64 in-out in 9.6447 Saltbr-out 4.6446 HRD-in -67.16, -56.28 75.39, -12.59 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -94.99, 104.56 APE9-dihe-na -79.86, 138.7 APE8-dihe-out -57.16, -42.08 APE8-rot-in 286.79 APE67-dihe-in -66.27, -23.7 -55.89, -29.45 APE12-dist-none 999.0 APE11-dist-in 11.6796 APE10-dist-out 11.2391 APE9-dist-out 10.8408 None None None XRAY 1.86 0.19 0.233 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6y4w Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4XA P47811 1 360 360.0 O8Q:408 Type2 Inactive DFGout 13.696 10.823 BBAminus -149.62, 179.62 -142.72, 111.56 -75.36, -7.07 282.26, 124.72 75.09, -147.71 out-out out 10.3547 Saltbr-out 4.8762 HRD-in -71.54, -55.5 78.1, -16.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -111.91, 118.92 APE9-dihe-na -79.94, 124.56 APE8-dihe-out -51.51, -36.52 APE8-rot-in 307.99 APE67-dihe-in -62.34, -27.48 -49.26, -35.94 APE12-dist-none 999.0 APE11-dist-in 12.2084 APE10-dist-out 13.0262 APE9-dist-out 10.4219 None None None XRAY 1.6 0.17 0.204 A 361.0 351.0 9 25 16 9 [[24, 308]] 1.0 6y4x Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y6VA P47811 4 353 360.0 OE5:401 Type2 Inactive DFGout 13.6416 11.1096 BBAminus -145.73, -174.56 -146.2, 109.18 -72.0, -9.8 285.19, 125.4 53.02, 999.0 in-out in 9.8914 Saltbr-out 4.9219 HRD-in -59.95, -60.79 80.44, -15.1 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.85 APE8-dihe-out -54.18, -38.73 APE8-rot-in 283.8 APE67-dihe-in -61.52, -30.99 -63.8, -27.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8289 None None None XRAY 2.1 0.251 0.304 A 361.0 331.0 19 25 12 13 [[24, 308]] 1.0 6y6v Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YJCA P47811 4 352 360.0 OSZ:401 Type2 Inactive DFGout 13.4586 10.5464 BBAminus -139.92, -176.5 -139.91, 106.09 -88.23, 0.66 289.05, 130.6 -62.56, 999.0 in-in in 9.1742 Saltbr-in 2.7269 HRD-in -65.02, -54.9 81.2, -12.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 140.28 APE9-dihe-na -70.4, -54.9 APE8-dihe-in -130.7, 144.29 APE8-rot-out 184.39 APE67-dihe-in -65.14, -20.31 -104.69, 2.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5174 None None None XRAY 1.741 0.203 0.237 A 361.0 337.0 12 25 13 12 [[24, 308]] 1.0 6yjc Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YK7A P47811 5 355 360.0 OU2:401 Type2 Inactive DFGout 13.2555 10.3644 BBAminus -133.06, 178.3 -142.12, 109.8 -80.39, -8.19 296.44, 118.38 65.61, -167.35 in-in in 9.2356 Saltbr-in 2.8771 HRD-in -73.77, -53.1 74.74, -13.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -83.66, 114.66 APE9-dihe-na -70.8, 127.89 APE8-dihe-out -51.01, -41.4 APE8-rot-in 286.15 APE67-dihe-in -63.42, -27.42 -60.43, -26.14 APE12-dist-none 999.0 APE11-dist-in 12.7948 APE10-dist-out 11.8108 APE9-dist-out 10.7927 None None None XRAY 1.9 0.186 0.235 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6yk7 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6ZWRA P47811 5 353 360.0 OEB:401 Type2 Inactive DFGout 13.1552 10.4118 BBAminus -133.95, 179.2 -142.59, 106.98 -78.63, -9.38 290.08, 122.21 73.33, -138.6 in-in in 9.0868 Saltbr-in 2.7177 HRD-in -66.13, -57.41 77.62, -9.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 100.49 APE9-dihe-na -73.84, 130.35 APE8-dihe-out -50.53, -43.01 APE8-rot-in 294.93 APE67-dihe-in -63.61, -24.53 -40.59, -45.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.191 APE9-dist-out 10.6586 None None None XRAY 1.9 0.196 0.225 A 361.0 338.0 11 25 14 11 [[24, 308]] 1.0 6zwr Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BDQA P47811 5 353 360.0 TJZ:401 Type2 Inactive DFGout 13.0071 10.439 BBAminus -145.11, -176.65 -143.25, 106.89 -85.99, -12.64 286.55, 130.41 87.01, 999.0 in-none in 9.7176 Saltbr-none 999.0 HRD-in -62.24, -58.93 83.9, -21.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 113.01 APE8-dihe-out -46.72, -43.24 APE8-rot-out 179.73 APE67-dihe-in -53.55, -29.55 -45.05, -55.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8206 None None None XRAY 2.75 0.218 0.262 A 361.0 336.0 13 25 12 13 [[24, 308]] 1.0 7bdq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BE4A P47811 4 352 360.0 TK5:401 Type2 Inactive DFGout 13.5254 10.6899 BBAminus -146.72, -171.32 -147.04, 99.47 -70.74, -21.85 288.34, 123.0 75.58, -140.33 in-out in 9.8945 Saltbr-out 4.6489 HRD-in -69.81, -56.07 78.08, -16.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 136.58 APE8-dihe-out -55.38, -36.52 APE8-rot-in 292.92 APE67-dihe-in -61.6, -24.47 -62.76, -30.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9196 None None None XRAY 2.1 0.217 0.268 A 361.0 331.0 18 25 13 12 [[24, 308]] 1.0 7be4 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BE5A P47811 4 352 360.0 TKB:403 Type2 Inactive DFGout 13.6504 10.8783 BBAminus -145.24, -177.93 -140.39, 104.25 -74.05, -22.12 289.39, 119.94 62.18, 999.0 in-in in 9.5284 Saltbr-in 3.0014 HRD-in -67.52, -58.26 81.02, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.64 APE8-dihe-out -48.96, -44.36 APE8-rot-in 280.11 APE67-dihe-in -63.22, -23.34 -38.31, -49.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9796 None None None XRAY 1.8 0.187 0.222 A 361.0 329.0 20 25 12 13 [[24, 308]] 1.0 7be5 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2PUUA P47811 5 352 360.0 G2G:391 Type2 Inactive DFGout 14.475 10.7348 BBAminus -163.02, -178.87 -141.37, 110.1 -71.36, -4.93 286.25, 81.16 73.38, 999.0 in-out in 9.3245 Saltbr-out 4.7622 HRD-in -69.43, -54.67 75.33, -3.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 89.4 APE9-dihe-na -57.27, 116.93 APE8-dihe-out -54.47, -25.97 APE8-rot-out 129.27 APE67-dihe-in -41.71, -26.91 -50.81, -61.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6894 N14A None None XRAY 2.5 0.228 0.318 A 348.0 330.0 18 25 13 12 [[24, 308]] 1.0 2puu Mus musculus CMGC_MAPK14_MOUSE CMGC 3.8e-85 291.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P5KA P47811 5 352 360.0 P5K:362 Type3 Inactive DFGout 14.5249 9.3083 BBAminus -141.15, -168.68 -148.23, 99.3 -58.18, -32.6 276.48, 90.7 88.55, 999.0 in-in in 8.6057 Saltbr-in 2.7902 HRD-in -63.98, -57.19 74.55, -12.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 150.21 APE8-dihe-out -61.52, -32.15 APE8-rot-in 260.23 APE67-dihe-in -70.66, -25.54 -65.62, -20.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5465 None None None XRAY 2.09 0.214 0.265 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p5k Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P78A P47811 5 352 360.0 P78:362 Type3 Inactive DFGout 13.7085 9.6676 BBAminus -145.29, -172.71 -144.52, 103.86 -60.78, -27.28 283.97, 109.45 117.0, 999.0 in-in in 9.4899 Saltbr-in 2.8442 HRD-in -69.5, -62.61 90.57, -20.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.4 APE8-dihe-out -43.61, -34.17 APE8-rot-in 261.47 APE67-dihe-in -68.8, -24.58 -57.91, -21.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8066 None None None XRAY 2.3 0.247 0.313 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p78 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P79A P47811 5 352 360.0 P79:362 Type3 Inactive DFGout 14.0002 9.8729 BBAminus -151.22, -174.47 -141.93, 101.48 -66.27, -17.47 283.09, 111.48 104.1, 999.0 in-in in 9.2282 Saltbr-in 2.7858 HRD-in -63.58, -58.2 79.24, -16.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.77 APE8-dihe-out -56.29, -31.49 APE8-rot-in 268.32 APE67-dihe-in -72.21, -24.76 -62.87, -19.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5235 None None None XRAY 2.1 0.213 0.27 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p79 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P7AA P47811 5 352 360.0 P7A:362 Type3 Inactive DFGout 14.0192 8.9506 BBAminus -141.3, -162.35 -154.35, 95.38 -72.41, 28.1 269.3, 92.19 44.28, 999.0 in-in in 8.8264 Saltbr-in 3.1582 HRD-in -68.47, -56.82 86.62, -20.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.86 APE8-dihe-out -40.2, -40.94 APE8-rot-in 279.74 APE67-dihe-in -55.35, -23.72 -65.33, -37.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0411 None None None XRAY 2.31 0.23 0.298 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p7a Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P7BA P47811 5 352 360.0 P7B:362 Type3 Inactive DFGout 14.3218 9.1308 BBAminus -139.72, -169.55 -146.44, 103.45 -68.51, -32.05 266.87, 101.4 106.97, 999.0 in-in in 8.8363 Saltbr-in 2.9154 HRD-in -63.72, -60.5 81.04, -16.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.57 APE8-dihe-out -51.57, -34.06 APE8-rot-in 268.36 APE67-dihe-in -70.75, -19.21 -60.51, -28.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4888 None None None XRAY 1.9 0.224 0.265 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p7b Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P7CA P47811 5 352 360.0 P7C:362 Type3 Inactive DFGout 14.1838 8.8862 BBAminus -148.94, 179.04 -136.31, 98.75 -67.28, -8.09 273.29, 107.9 73.35, 999.0 in-in in 8.6654 Saltbr-in 3.0018 HRD-in -66.58, -58.56 78.92, -19.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.98 APE8-dihe-out -68.5, -25.84 APE8-rot-out 232.65 APE67-dihe-in -58.76, -32.39 -62.96, -27.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8868 None None None XRAY 2.3 0.239 0.292 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p7c Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BDOA P47811 5 353 360.0 TBK:401 Type2 Inactive DFGout 13.2743 10.6119 None -140.45, -176.17 -147.11, 100.95 -81.65, 173.27 306.65, 120.36 -120.47, 69.03 in-out in 9.678 Saltbr-out 5.5219 HRD-in -63.13, -55.95 75.66, -10.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.1 APE8-dihe-out -57.45, -51.16 APE8-rot-in 302.29 APE67-dihe-in -59.24, -31.49 -45.26, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8124 None None None XRAY 2.7 0.241 0.287 A 361.0 332.0 17 25 13 12 [[24, 308]] 1.0 7bdo Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZH P47811 5 352 360.0 AGS:60500 ATPlike None DFGin 6.5201 14.9123 BLAminus -107.76, 173.34 60.28, 95.29 -107.52, 29.84 280.25, 79.55 -61.87, -24.37 in-none in 9.249 Saltbr-none 999.0 HRD-in -88.17, -55.8 88.26, -17.82 none-in-in SNCnii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.4, 153.2 APE9-dihe-na 72.78, 157.17 APE8-dihe-in -63.99, 158.8 APE8-rot-in 301.47 APE67-dihe-in -70.1, -20.58 -71.77, -51.25 APE12-dist-in 12.0483 APE11-dist-in 11.371 APE10-dist-in 7.6507 APE9-dist-in 3.3502 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 H 360.0 337.0 9 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

CMGC_MAPK14 (Mitogen-activated protein kinase 14)

Total number of chains: 139
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 73 52.5% 5R97A
DFGin BLBplus 22 15.8% 4LOOA
DFGout BBAminus 20 14.4% 5LARA
DFGin None 15 10.8% 5R9UA
DFGin BLAminus 7 5.0% 3PY3A
DFGin ABAminus 1 0.7% 7PVUA
DFGout None 1 0.7% 7BDOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAPK14 MK14_MOUSE 5NZZE P47811 4 353 360.0 AGS:60401 ATPlike Active DFGin 6.5145 14.9809 BLAminus -122.06, 164.78 72.33, 78.3 -82.97, 27.83 284.83, 92.09 -68.73, -16.77 in-in in 9.4753 Saltbr-in 3.5664 HRD-in -92.47, -52.47 76.16, -3.26 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.62, 176.88 APE9-dihe-na 58.43, 166.45 APE8-dihe-in -84.96, 144.19 APE8-rot-in 316.3 APE67-dihe-in -61.16, -25.49 -55.46, -53.03 APE12-dist-in 11.933 APE11-dist-in 11.3947 APE10-dist-in 7.2363 APE9-dist-in 3.1259 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 E 360.0 345.0 5 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZF P47811 5 353 360.0 AGS:60401 ATPlike Active DFGin 6.5814 14.7457 BLAminus -104.46, 169.41 67.42, 93.44 -106.87, 21.93 284.61, 82.38 -60.31, -14.32 in-in in 9.3181 Saltbr-in 2.6918 HRD-in -84.83, -58.57 70.0, 21.45 in-in-in SNCiii in-in ActLoopNT-in 3.0664 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.79, 145.31 APE9-dihe-na 83.88, 162.38 APE8-dihe-in -79.27, 130.51 APE8-rot-in 303.15 APE67-dihe-in -54.1, -23.47 -46.06, -59.5 APE12-dist-in 11.9255 APE11-dist-in 11.5323 APE10-dist-in 7.2453 APE9-dist-in 3.3341 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 F 360.0 343.0 6 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7PVUA P47811 5 353 360.0 No_ligand No_ligand Inactive DFGin 5.6168 15.1593 ABAminus -94.57, -36.92 -122.93, 174.85 -130.26, 15.13 303.73, 103.6 73.11, 17.43 out-out out 10.5221 Saltbr-out 5.0442 HRD-in -76.13, -63.33 89.97, -15.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -64.18 APE8-dihe-in -149.52, 134.03 APE8-rot-out 185.0 APE67-dihe-in -66.63, -19.36 -112.0, 8.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8989 None None None XRAY 2.154 0.207 0.239 A 359.0 337.0 12 25 13 12 [[24, 308]] 1.0 7pvu Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZG P47811 5 353 360.0 AGS:60500 ATPlike Inactive DFGin 6.7542 14.7083 BLAminus -116.89, 166.61 73.83, 77.69 -92.77, 19.2 291.57, 84.89 -50.42, -23.42 in-out in 9.7677 Saltbr-out 3.6394 HRD-in -81.86, -61.67 80.49, 3.8 out-in-in SNCoii in-in ActLoopNT-in 3.0358 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.71, 150.03 APE9-dihe-na 72.19, 148.63 APE8-dihe-in -60.61, 140.23 APE8-rot-in 308.55 APE67-dihe-in -63.92, -23.58 -59.84, -44.11 APE12-dist-in 11.9561 APE11-dist-in 11.829 APE10-dist-in 7.4102 APE9-dist-in 3.3534 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 G 360.0 344.0 5 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2OZAB P47811 6 353 360.0 No_ligand No_ligand Inactive DFGin 7.7822 16.0068 BLAminus -118.23, 171.93 54.76, 85.27 -98.04, -31.59 288.8, 55.22 -31.15, 9.05 out-out out 11.0093 Saltbr-out 5.161 HRD-in -57.49, -58.06 98.2, -27.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -133.01, 138.56 APE9-dihe-na -87.21, -22.73 APE8-dihe-in -156.9, 157.2 APE8-rot-out 72.26 APE67-dihe-in -61.42, -8.66 -124.37, 38.47 APE12-dist-in 9.3621 APE11-dist-in 12.6039 APE10-dist-out 10.1881 APE9-dist-out 12.9814 None None None XRAY 2.7 0.239 0.296 B 366.0 340.0 8 25 17 8 [[24, 308]] 1.0 2oza Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3PY3A P47811 1 354 360.0 No_ligand No_ligand Inactive DFGin 6.7741 16.154 BLAminus -107.18, 162.59 73.02, 100.48 -107.92, 21.45 284.78, 77.62 -59.69, -38.19 out-out out 11.3048 Saltbr-out 5.3477 HRD-in -69.48, -46.17 76.52, -12.87 out-in-out SNCoio in-out ActLoopNT-in 2.7663 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -83.88, 106.41 APE9-dihe-na -79.77, -18.34 APE8-dihe-in -66.16, 122.11 APE8-rot-in 299.66 APE67-dihe-in -70.9, -29.93 -90.94, -45.01 APE12-dist-out 6.6053 APE11-dist-in 9.0286 APE10-dist-in 6.8328 APE9-dist-out 8.1216 None TPO180,PTR182 TPO180,PTR182 XRAY 2.1 0.215 0.24 A 380.0 354.0 0 25 25 0 [[24, 308]] 1.0 3py3 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4TYHB P47811 6 353 360.0 39G:401 Type1.5_Back Inactive DFGin 7.39 16.0222 BLAminus -100.73, 158.14 81.52, 87.17 -105.84, 20.18 292.32, 72.56 -57.61, -46.84 out-out out 10.7337 Saltbr-out 5.5492 HRD-in -67.8, -42.55 76.87, -55.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -132.03, 125.28 APE9-dihe-na -64.76, -61.75 APE8-dihe-in -121.75, 174.44 APE8-rot-out 56.39 APE67-dihe-out -76.5, -21.76 -153.78, 65.22 APE12-dist-in 10.0478 APE11-dist-in 12.7972 APE10-dist-out 9.8392 APE9-dist-out 12.8344 None None None XRAY 3.0 0.232 0.313 B 348.0 335.0 13 25 17 8 [[24, 308]] 1.0 4tyh Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8VA P47811 5 352 360.0 SLV:401 Allosteric Inactive DFGin 7.6242 17.1526 BLBminus -126.3, 168.82 56.55, 59.16 -55.68, 146.02 284.01, 72.07 -69.49, 121.4 in-in in 9.8917 Saltbr-in 2.7978 HRD-in -67.25, -52.7 83.66, -13.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.92, 131.25 APE9-dihe-na -62.03, -18.21 APE8-dihe-out -61.99, -18.31 APE8-rot-out 54.16 APE67-dihe-in -64.25, -20.09 -113.24, -17.54 APE12-dist-out 21.8414 APE11-dist-out 24.0264 APE10-dist-out 18.3188 APE9-dist-out 11.8622 None None None XRAY 1.479 0.18 0.195 A 360.0 347.0 1 25 24 1 [[24, 308]] 1.0 5r8v Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8WA P47811 5 352 360.0 JND:401 Allosteric Inactive DFGin 7.6227 17.1396 BLBminus -134.39, -175.76 54.2, 58.03 -54.53, 148.27 282.17, 71.55 -69.56, 120.12 in-in in 9.786 Saltbr-in 2.7971 HRD-in -69.08, -52.16 84.44, -11.95 in-out-out SNCioo out-out ActLoopNT-out 10.527 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.15, 133.86 APE9-dihe-na -63.5, -21.8 APE8-dihe-out -56.73, -22.52 APE8-rot-out 52.13 APE67-dihe-in -65.69, -17.77 -112.94, -20.97 APE12-dist-out 21.8759 APE11-dist-out 24.1357 APE10-dist-out 18.3954 APE9-dist-out 11.8458 None None None XRAY 1.5 0.186 0.201 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r8w Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8XA P47811 5 352 360.0 SLY:401 Allosteric Inactive DFGin 7.7606 16.9981 BLBminus -136.1, -175.23 50.71, 58.98 -55.89, 147.73 286.33, 69.34 -66.18, 109.61 in-in in 9.6118 Saltbr-in 2.9715 HRD-in -65.45, -55.16 83.61, -13.56 in-out-out SNCioo out-out ActLoopNT-out 11.133 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.33, 135.56 APE9-dihe-na -62.93, -23.96 APE8-dihe-out -59.18, -23.72 APE8-rot-out 54.02 APE67-dihe-in -65.06, -22.4 -109.5, -17.51 APE12-dist-out 22.3746 APE11-dist-out 24.4521 APE10-dist-out 18.6895 APE9-dist-out 11.7277 None None None XRAY 1.73 0.221 0.249 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r8x Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R93A P47811 4 352 360.0 SOJ:401 Allosteric Inactive DFGin 7.6364 17.141 BLBminus -125.0, 173.15 52.85, 61.08 -58.46, 147.19 282.32, 72.46 -70.36, 117.48 in-in in 9.7995 Saltbr-in 2.729 HRD-in -68.86, -51.59 81.16, -8.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.22, 132.58 APE9-dihe-na -63.34, -21.4 APE8-dihe-out -60.14, -20.67 APE8-rot-out 52.37 APE67-dihe-in -64.7, -19.44 -110.4, -17.18 APE12-dist-out 21.9032 APE11-dist-out 24.1105 APE10-dist-out 18.3702 APE9-dist-out 11.8681 None None None XRAY 1.489 0.186 0.195 A 360.0 348.0 1 25 24 1 [[24, 308]] 1.0 5r93 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R94A P47811 4 352 360.0 SOV:401 Allosteric Inactive DFGin 7.729 17.235 BLBminus -137.79, -178.74 55.84, 58.89 -57.59, 145.63 283.29, 72.29 -71.48, 114.45 in-in in 9.9283 Saltbr-in 2.9121 HRD-in -71.58, -53.08 83.28, -14.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.94, 131.9 APE9-dihe-na -62.45, -19.9 APE8-dihe-out -63.18, -16.73 APE8-rot-out 56.42 APE67-dihe-in -63.19, -21.64 -113.72, -19.73 APE12-dist-out 21.9777 APE11-dist-out 24.1871 APE10-dist-out 18.4441 APE9-dist-out 11.695 None None None XRAY 1.45 0.187 0.202 A 360.0 346.0 3 25 24 1 [[24, 308]] 1.0 5r94 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R95A P47811 4 352 360.0 SQ4:401 Allosteric Inactive DFGin 7.6695 17.1549 BLBminus -139.99, 179.44 56.08, 59.11 -58.27, 147.31 284.25, 68.55 -71.3, 107.79 in-in in 9.8852 Saltbr-in 2.8773 HRD-in -70.53, -53.74 79.75, -8.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.16, 132.42 APE9-dihe-na -63.75, -20.7 APE8-dihe-out -61.61, -19.73 APE8-rot-out 47.85 APE67-dihe-in -66.31, -19.82 -108.94, -17.23 APE12-dist-out 22.0039 APE11-dist-out 24.1865 APE10-dist-out 18.4173 APE9-dist-out 11.7229 None None None XRAY 1.59 0.192 0.204 A 360.0 346.0 3 25 24 1 [[24, 308]] 1.0 5r95 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R96A P47811 5 352 360.0 SQ7:401 Allosteric Inactive DFGin 7.6611 17.0905 BLBminus -136.37, -175.98 52.57, 61.74 -57.12, 147.65 283.47, 72.37 -70.19, 115.33 in-in in 9.8391 Saltbr-in 2.8116 HRD-in -68.37, -54.39 82.83, -12.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.21, 132.91 APE9-dihe-na -62.49, -21.62 APE8-dihe-out -60.28, -18.42 APE8-rot-out 52.24 APE67-dihe-in -64.9, -19.79 -112.71, -17.38 APE12-dist-out 21.9437 APE11-dist-out 24.187 APE10-dist-out 18.4437 APE9-dist-out 11.801 None None None XRAY 1.767 0.19 0.208 A 360.0 347.0 1 25 24 1 [[24, 308]] 1.0 5r96 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R98A P47811 5 352 360.0 SQG:401 Allosteric Inactive DFGin 7.6301 17.1531 BLBminus -139.69, -178.58 52.8, 60.22 -55.35, 146.47 284.25, 73.05 -71.74, 116.58 in-in in 9.8111 Saltbr-in 2.6872 HRD-in -69.0, -53.85 86.37, -15.46 in-out-out SNCioo out-out ActLoopNT-out 10.4878 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 131.88 APE9-dihe-na -62.6, -21.66 APE8-dihe-out -56.26, -26.27 APE8-rot-out 54.12 APE67-dihe-in -65.77, -18.3 -106.91, -14.96 APE12-dist-out 21.9117 APE11-dist-out 24.0966 APE10-dist-out 18.3637 APE9-dist-out 11.9084 None None None XRAY 1.68 0.183 0.2 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r98 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9AA P47811 5 352 360.0 SQM:401 Allosteric Inactive DFGin 7.5742 16.9369 BLBminus -126.82, 171.96 55.5, 57.75 -54.21, 144.16 285.22, 72.17 -66.56, 117.45 in-in in 9.7078 Saltbr-in 2.7238 HRD-in -69.92, -51.48 82.76, -10.56 in-out-out SNCioo out-out ActLoopNT-out 10.333 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.99, 130.14 APE9-dihe-na -62.59, -20.55 APE8-dihe-out -58.17, -22.41 APE8-rot-out 44.82 APE67-dihe-in -64.14, -18.64 -111.32, -17.69 APE12-dist-out 21.9802 APE11-dist-out 24.1461 APE10-dist-out 18.4075 APE9-dist-out 11.9533 None None None XRAY 1.53 0.196 0.208 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9a Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9BA P47811 5 352 360.0 JGM:401 Allosteric Inactive DFGin 7.7898 17.2212 BLBminus -137.89, -179.24 56.02, 58.96 -56.41, 146.75 282.82, 70.11 -71.44, 114.16 in-in in 9.7364 Saltbr-in 2.7607 HRD-in -71.08, -50.92 79.7, -15.14 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.68, 134.09 APE9-dihe-na -64.15, -19.43 APE8-dihe-out -62.84, -16.8 APE8-rot-out 55.38 APE67-dihe-in -65.51, -20.17 -113.81, -18.43 APE12-dist-out 21.9741 APE11-dist-out 24.2022 APE10-dist-out 18.4845 APE9-dist-out 11.7343 None None None XRAY 1.657 0.186 0.199 A 360.0 343.0 5 25 23 2 [[24, 308]] 1.0 5r9b Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9GA P47811 5 352 360.0 RGY:401 Allosteric Inactive DFGin 7.7265 17.0303 BLBminus -134.4, -175.55 57.07, 56.97 -55.58, 148.2 283.12, 71.34 -71.62, 105.51 in-in in 9.7003 Saltbr-in 2.7991 HRD-in -70.39, -55.26 82.6, -12.5 in-out-out SNCioo out-out ActLoopNT-out 10.9549 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.74, 135.25 APE9-dihe-na -63.35, -22.47 APE8-dihe-out -62.02, -18.5 APE8-rot-out 52.77 APE67-dihe-in -65.69, -20.71 -112.46, -19.93 APE12-dist-out 22.4508 APE11-dist-out 24.5661 APE10-dist-out 18.8167 APE9-dist-out 11.7175 None None None XRAY 1.73 0.177 0.195 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9g Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9HA P47811 5 352 360.0 SQV:401 Allosteric Inactive DFGin 7.6496 17.2459 BLBminus -137.89, -178.38 55.0, 58.67 -58.2, 147.67 282.66, 71.45 -69.93, 114.78 in-in in 9.9224 Saltbr-in 2.9457 HRD-in -70.31, -52.25 80.68, -10.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.63, 133.21 APE9-dihe-na -64.5, -19.28 APE8-dihe-out -61.91, -17.26 APE8-rot-out 53.17 APE67-dihe-in -64.9, -19.31 -113.89, -19.68 APE12-dist-out 21.9599 APE11-dist-out 24.1502 APE10-dist-out 18.3829 APE9-dist-out 11.7021 None None None XRAY 1.49 0.194 0.201 A 360.0 344.0 4 25 24 1 [[24, 308]] 1.0 5r9h Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9OA P47811 5 352 360.0 54F:401 Allosteric Inactive DFGin 7.6735 17.2107 BLBminus -136.39, -176.43 54.27, 60.09 -56.75, 144.98 283.51, 68.16 -67.8, 120.41 in-in in 9.802 Saltbr-in 2.8748 HRD-in -68.65, -55.19 86.09, -8.85 in-out-out SNCioo out-out ActLoopNT-out 10.3121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.85, 133.85 APE9-dihe-na -63.65, -21.53 APE8-dihe-out -61.93, -15.63 APE8-rot-out 53.56 APE67-dihe-in -63.52, -19.95 -117.35, -20.3 APE12-dist-out 21.9806 APE11-dist-out 24.1562 APE10-dist-out 18.3738 APE9-dist-out 11.8682 None None None XRAY 1.6 0.18 0.196 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9o Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9SA P47811 5 352 360.0 A9B:401 Allosteric Inactive DFGin 7.6484 17.0877 BLBminus -130.76, -174.94 52.61, 58.63 -54.81, 145.68 282.32, 73.37 -69.93, 118.55 in-in in 9.723 Saltbr-in 2.8924 HRD-in -68.6, -55.2 87.53, -15.82 in-out-out SNCioo out-out ActLoopNT-out 10.4211 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.15, 132.28 APE9-dihe-na -59.28, -26.61 APE8-dihe-out -57.14, -23.52 APE8-rot-out 51.46 APE67-dihe-in -63.1, -22.14 -110.76, -19.59 APE12-dist-out 22.0198 APE11-dist-out 24.1764 APE10-dist-out 18.3734 APE9-dist-out 11.8169 None None None XRAY 1.7 0.181 0.199 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9s Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9TA P47811 5 352 360.0 6T5:401 Allosteric Inactive DFGin 7.6529 17.225 BLBminus -134.58, 179.37 56.46, 61.42 -59.37, 143.77 284.46, 67.39 -62.94, 118.41 in-in in 9.747 Saltbr-in 2.8025 HRD-in -73.0, -49.97 79.73, -16.48 in-out-out SNCioo out-out ActLoopNT-out 10.4848 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.55, 133.75 APE9-dihe-na -63.67, -19.36 APE8-dihe-out -55.68, -28.19 APE8-rot-out 60.37 APE67-dihe-in -64.14, -18.0 -107.35, -18.11 APE12-dist-out 21.7698 APE11-dist-out 23.9495 APE10-dist-out 18.2248 APE9-dist-out 11.8023 None None None XRAY 1.8 0.193 0.222 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r9t Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9VA P47811 5 352 360.0 SSY:401 Allosteric Inactive DFGin 7.6279 17.0477 BLBminus -135.76, -174.98 54.29, 60.29 -54.36, 146.37 281.79, 73.25 -72.64, 118.79 in-in in 9.7606 Saltbr-in 2.8035 HRD-in -68.33, -52.97 82.92, -13.14 in-out-out SNCioo out-out ActLoopNT-out 10.3746 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.31, 133.8 APE9-dihe-na -62.94, -22.2 APE8-dihe-out -59.72, -21.1 APE8-rot-out 55.08 APE67-dihe-in -59.37, -22.0 -112.25, -26.14 APE12-dist-out 21.9536 APE11-dist-out 24.1672 APE10-dist-out 18.381 APE9-dist-out 11.6748 None None None XRAY 1.45 0.181 0.19 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9v Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9XA P47811 5 352 360.0 NZ4:401 Allosteric Inactive DFGin 7.6059 16.9807 BLBminus -133.11, -174.37 54.03, 59.46 -56.62, 145.82 285.46, 72.48 -68.38, 112.73 in-in in 9.81 Saltbr-in 2.8595 HRD-in -71.45, -53.15 83.16, -9.9 in-out-out SNCioo out-out ActLoopNT-out 10.0759 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.55, 132.59 APE9-dihe-na -64.28, -22.62 APE8-dihe-out -59.84, -17.55 APE8-rot-out 54.35 APE67-dihe-in -63.07, -20.46 -114.39, -20.36 APE12-dist-out 22.2549 APE11-dist-out 24.4395 APE10-dist-out 18.6278 APE9-dist-out 11.9119 None None None XRAY 1.72 0.18 0.202 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r9x Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9ZA P47811 5 352 360.0 AYS:401 Allosteric Inactive DFGin 7.6735 17.1058 BLBminus -133.13, -174.7 54.53, 56.1 -53.58, 144.14 285.01, 73.51 -69.81, 113.39 in-in in 9.8973 Saltbr-in 2.8298 HRD-in -68.34, -54.55 85.95, -12.36 in-out-out SNCioo out-out ActLoopNT-out 10.3695 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.12, 133.3 APE9-dihe-na -63.62, -25.19 APE8-dihe-out -57.92, -20.5 APE8-rot-out 51.08 APE67-dihe-in -62.29, -25.61 -112.35, -21.18 APE12-dist-out 22.1321 APE11-dist-out 24.2381 APE10-dist-out 18.4298 APE9-dist-out 11.7809 None None None XRAY 1.66 0.179 0.197 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9z Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA3A P47811 5 352 360.0 SVD:401 Allosteric Inactive DFGin 7.6779 16.9416 BLBminus -126.34, 179.2 56.7, 55.93 -51.74, 142.55 283.17, 74.34 -63.1, 112.19 in-in in 9.7539 Saltbr-in 2.7895 HRD-in -69.43, -52.58 81.78, -10.99 in-out-out SNCioo out-out ActLoopNT-out 10.5027 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.85, 132.04 APE9-dihe-na -60.7, -20.75 APE8-dihe-out -61.18, -22.1 APE8-rot-out 57.18 APE67-dihe-in -63.03, -21.89 -113.08, -19.76 APE12-dist-out 22.0459 APE11-dist-out 24.2893 APE10-dist-out 18.5343 APE9-dist-out 11.9139 None None None XRAY 1.57 0.212 0.229 A 360.0 345.0 3 25 25 0 [[24, 308]] 1.0 5ra3 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA4A P47811 5 352 360.0 SVG:401 Allosteric Inactive DFGin 7.653 17.0437 BLBminus -130.79, -174.79 52.38, 60.78 -56.74, 147.03 281.5, 76.16 -70.86, 116.26 in-in in 9.729 Saltbr-in 2.8302 HRD-in -71.41, -53.27 80.45, -7.1 in-out-out SNCioo out-out ActLoopNT-out 10.3013 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.54, 132.79 APE9-dihe-na -63.25, -22.78 APE8-dihe-out -60.03, -18.29 APE8-rot-out 51.8 APE67-dihe-in -64.64, -18.17 -114.64, -21.82 APE12-dist-out 21.9864 APE11-dist-out 24.2049 APE10-dist-out 18.4197 APE9-dist-out 11.7767 None None None XRAY 1.59 0.184 0.199 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra4 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA5A P47811 5 352 360.0 SVJ:401 Allosteric Inactive DFGin 7.6769 17.1318 BLBminus -134.61, -174.21 50.91, 61.55 -54.67, 146.72 280.99, 77.86 -69.78, 116.61 in-in in 9.7787 Saltbr-in 2.8482 HRD-in -69.58, -53.21 81.06, -8.28 in-out-out SNCioo out-out ActLoopNT-out 10.0897 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.75, 130.27 APE9-dihe-na -62.89, -20.53 APE8-dihe-out -60.05, -19.39 APE8-rot-out 51.5 APE67-dihe-in -65.85, -14.96 -114.99, -21.7 APE12-dist-out 22.0635 APE11-dist-out 24.3067 APE10-dist-out 18.5468 APE9-dist-out 11.7651 None None None XRAY 1.54 0.183 0.198 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra5 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOIA P47811 4 352 360.0 LOK:401 Allosteric Inactive DFGin 7.6003 17.1296 BLBminus -138.61, -177.05 54.96, 58.72 -56.67, 146.48 284.49, 69.56 -71.01, 109.8 in-in in 9.8435 Saltbr-in 2.8732 HRD-in -70.18, -53.83 83.4, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.67, 133.12 APE9-dihe-na -65.95, -18.62 APE8-dihe-out -58.87, -19.51 APE8-rot-out 50.31 APE67-dihe-in -63.43, -19.73 -113.68, -18.38 APE12-dist-out 22.0101 APE11-dist-out 24.195 APE10-dist-out 18.4783 APE9-dist-out 11.7667 None None None XRAY 1.55 0.211 0.234 A 380.0 346.0 3 25 24 1 [[24, 308]] 1.0 6soi Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SO1A P47811 5 352 360.0 LO5:401 Allosteric Inactive DFGin 7.658 17.0391 BLBminus -135.08, -176.54 51.6, 60.96 -56.09, 146.29 284.52, 70.34 -67.64, 113.41 in-in in 9.8471 Saltbr-in 2.8249 HRD-in -69.25, -52.88 79.19, -11.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.6, 132.96 APE9-dihe-na -61.83, -21.36 APE8-dihe-out -63.21, -14.73 APE8-rot-out 51.84 APE67-dihe-in -64.64, -20.67 -114.01, -18.86 APE12-dist-out 21.9498 APE11-dist-out 24.1112 APE10-dist-out 18.3716 APE9-dist-out 11.6413 None None None XRAY 1.66 0.187 0.204 A 381.0 343.0 5 25 23 2 [[24, 308]] 1.0 6so1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SO2A P47811 4 352 360.0 JGG:401 Allosteric Inactive DFGin 7.6274 16.9267 BLBminus -135.57, 179.75 55.15, 60.68 -57.52, 146.11 285.62, 69.71 -68.14, 118.76 in-in in 9.8446 Saltbr-in 2.7969 HRD-in -70.11, -51.91 80.58, -12.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 132.29 APE9-dihe-na -61.32, -22.39 APE8-dihe-out -62.87, -12.7 APE8-rot-out 57.5 APE67-dihe-in -63.09, -21.09 -115.95, -19.85 APE12-dist-out 22.0177 APE11-dist-out 24.188 APE10-dist-out 18.4392 APE9-dist-out 11.673 None None None XRAY 1.6 0.185 0.193 A 381.0 345.0 4 25 23 2 [[24, 308]] 1.0 6so2 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SO4A P47811 5 352 360.0 LO8:401 Allosteric Inactive DFGin 7.5993 17.0443 BLBminus -135.53, -177.23 56.32, 58.65 -57.36, 146.69 283.65, 71.71 -69.82, 110.96 in-in in 9.768 Saltbr-in 2.7738 HRD-in -71.08, -52.37 79.77, -9.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.06, 133.58 APE9-dihe-na -64.96, -18.16 APE8-dihe-out -63.58, -15.55 APE8-rot-out 53.76 APE67-dihe-in -66.99, -20.52 -115.06, -16.09 APE12-dist-out 22.0173 APE11-dist-out 24.1969 APE10-dist-out 18.446 APE9-dist-out 11.773 None None None XRAY 1.51 0.214 0.228 A 381.0 343.0 5 25 23 2 [[24, 308]] 1.0 6so4 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SODA P47811 5 352 360.0 LOE:401 Allosteric Inactive DFGin 7.5743 17.0706 BLBminus -137.18, -176.29 55.07, 60.36 -59.01, 143.71 284.33, 71.06 -68.11, 116.87 in-none in 9.905 Saltbr-none 999.0 HRD-in -67.45, -53.5 81.24, -11.19 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.73, 132.94 APE9-dihe-na -62.6, -20.06 APE8-dihe-out -63.14, -19.99 APE8-rot-out 54.04 APE67-dihe-in -64.93, -19.97 -108.41, -16.54 APE12-dist-out 22.022 APE11-dist-out 24.1848 APE10-dist-out 18.4227 APE9-dist-out 11.8419 None None None XRAY 1.87 0.191 0.204 A 381.0 345.0 3 25 23 2 [[24, 308]] 1.0 6sod Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOTA P47811 5 352 360.0 LOQ:401 Allosteric Inactive DFGin 7.6209 17.0755 BLBminus -135.94, -177.19 53.97, 59.82 -55.74, 146.14 283.57, 73.95 -69.99, 114.99 in-in in 9.8146 Saltbr-in 2.8826 HRD-in -69.44, -54.13 83.61, -15.08 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.13, 133.72 APE9-dihe-na -65.65, -18.12 APE8-dihe-out -63.48, -14.82 APE8-rot-out 46.93 APE67-dihe-in -63.68, -20.51 -114.08, -19.2 APE12-dist-out 21.9926 APE11-dist-out 24.1895 APE10-dist-out 18.4162 APE9-dist-out 11.6962 None None None XRAY 1.54 0.211 0.231 A 381.0 342.0 6 25 23 2 [[24, 308]] 1.0 6sot Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9MA P47811 5 352 360.0 A7K:401,A7K:402 Allosteric,Allosteric Inactive DFGin 7.5883 17.1408 BLBminus -136.87, -176.16 51.91, 61.14 -56.97, 145.87 284.55, 73.06 -74.07, 108.58 in-in in 9.9746 Saltbr-in 2.9082 HRD-in -68.84, -53.47 83.15, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.61, 132.14 APE9-dihe-na -63.64, -20.07 APE8-dihe-out -60.41, -20.56 APE8-rot-out 51.41 APE67-dihe-in -66.6, -19.97 -109.87, -16.5 APE12-dist-out 22.046 APE11-dist-out 24.1829 APE10-dist-out 18.4294 APE9-dist-out 11.8105 None None None XRAY 1.809 0.184 0.199 A 360.0 341.0 7 25 23 2 [[24, 308]] 1.0 5r9m Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1LEWA P47811 5 354 360.0 No_ligand No_ligand Inactive DFGin 7.4633 16.4972 BLBminus -127.25, -179.22 41.37, 70.66 -65.36, 149.47 289.38, 51.62 -76.18, 122.9 in-in in 9.8118 Saltbr-in 2.6178 HRD-in -60.7, -50.62 75.36, -7.59 in-out-out SNCioo out-out ActLoopNT-out 9.0538 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -152.34 APE9-dihe-na -143.4, -102.57 APE8-dihe-out -17.97, -56.94 APE8-rot-in 286.63 APE67-dihe-in -60.23, -19.01 -51.04, -36.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.8616 APE9-dist-out 11.5335 None None None XRAY 2.3 0.245 0.257 A 360.0 341.0 9 25 16 9 [[24, 308]] 1.0 1lew Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1LEZA P47811 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.4321 16.6258 BLBminus -119.38, -179.63 36.99, 72.05 -62.99, 142.29 290.92, 58.12 -68.79, 128.84 in-in in 9.8378 Saltbr-in 3.0077 HRD-in -59.03, -47.57 75.45, -14.7 in-out-out SNCioo out-out ActLoopNT-out 10.4145 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 154.62, 130.36 APE9-dihe-na -61.38, -56.46 APE8-dihe-out -54.42, -46.27 APE8-rot-in 286.56 APE67-dihe-in -60.01, -23.17 -59.69, -32.97 APE12-dist-none 999.0 APE11-dist-out 23.2792 APE10-dist-out 17.9984 APE9-dist-out 11.4669 None None None XRAY 2.3 0.247 0.249 A 360.0 343.0 7 25 18 7 [[24, 308]] 1.0 1lez Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4KA3A P47811 4 354 360.0 No_ligand No_ligand Inactive DFGin 7.3535 16.1489 BLBminus -139.92, 169.36 58.93, 50.7 -50.8, 136.6 293.23, 65.74 -57.05, 132.74 in-in in 9.5702 Saltbr-in 3.0125 HRD-in -64.83, -49.71 85.54, -7.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -81.99 APE8-dihe-out -71.42, -34.21 APE8-rot-out 228.85 APE67-dihe-in -64.35, -21.2 -64.38, -26.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8827 None None None XRAY 2.707 0.225 0.267 A 360.0 340.0 11 25 14 11 [[24, 308]] 1.0 4ka3 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8YPFA P47811 5 353 360.0 No_ligand No_ligand Inactive DFGin 8.0231 16.7688 BLBminus -111.38, 168.27 61.8, 65.14 -68.47, 150.01 282.99, 63.86 -56.92, 999.0 in-in in 9.7222 Saltbr-in 2.774 HRD-in -71.93, -50.08 76.29, -10.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -20.77 APE8-dihe-out -57.69, -40.15 APE8-rot-in 268.26 APE67-dihe-in -62.53, -21.95 -63.26, -31.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5207 None None None XRAY 2.0 0.192 0.218 A 360.0 336.0 13 25 12 13 [[24, 308]] 1.0 8ypf Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8YPEA P47811 1 353 360.0 No_ligand No_ligand Inactive DFGin 8.0712 16.6118 BLBminus -119.57, 172.41 55.63, 61.52 -65.14, 145.77 279.11, 61.33 -71.59, 117.4 in-in in 9.4469 Saltbr-in 2.7496 HRD-in -67.38, -46.31 76.43, -18.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.73 APE8-dihe-in -75.24, 139.72 APE8-rot-out 185.33 APE67-dihe-in -59.42, -19.13 -105.03, 0.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8293 None None None XRAY 1.95 0.198 0.225 A 362.0 342.0 11 25 14 11 [[24, 308]] 1.0 8ype Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P4KA P47811 4 353 360.0 No_ligand No_ligand Inactive DFGin 7.6209 16.6942 BLBminus -115.36, 175.26 45.65, 64.94 -53.3, 144.21 298.72, 64.73 -77.54, 138.8 in-in in 9.8102 Saltbr-in 3.1274 HRD-in -69.1, -51.07 78.1, -17.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 6.46 APE8-dihe-out 65.74, 112.23 APE8-rot-in 292.55 APE67-dihe-in -66.06, -22.6 -109.02, -6.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9676 S28A None None XRAY 2.304 0.179 0.239 A 370.0 338.0 12 25 13 12 [[24, 308]] 1.0 3p4k Mus musculus CMGC_MAPK14_MOUSE CMGC 2.6e-85 292.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5UOJA P47811 5 353 360.0 No_ligand No_ligand Inactive DFGin 7.3433 16.9665 BLBminus -124.98, 174.69 53.78, 57.97 -59.14, 144.23 289.53, 74.34 -78.97, 103.61 out-out out 10.0861 Saltbr-out 5.3395 HRD-in -64.82, -55.28 79.99, -9.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.38, 126.07 APE9-dihe-na -49.77, -40.48 APE8-dihe-out -57.2, -40.83 APE8-rot-out 188.73 APE67-dihe-in -64.28, -25.71 -72.72, -20.17 APE12-dist-out 22.2949 APE11-dist-out 24.5513 APE10-dist-out 18.7898 APE9-dist-out 11.9987 None None None XRAY 2.1 0.157 0.214 A 379.0 343.0 6 25 19 6 [[24, 308]] 1.0 5uoj Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8YP8A P47811 1 353 360.0 No_ligand No_ligand Inactive DFGin 8.0379 16.5298 BLBminus -114.8, 172.08 51.68, 65.57 -64.23, 147.07 283.41, 55.34 -60.66, 123.06 in-in in 9.1931 Saltbr-in 2.7009 HRD-in -65.26, -50.86 84.01, -20.01 in-out-none SNCion out-none ActLoopNT-out 10.1901 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.82 APE8-rot-in 277.38 APE67-dihe-in -54.85, -21.48 -97.3, -3.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.188 0.216 A 379.0 342.0 11 25 14 11 [[24, 308]] 1.0 8yp8 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7Z9TAAA P47811 5 353 360.0 87B:401 Type1 Inactive DFGin 6.1799 14.3876 BLBminus -108.1, 162.59 42.6, 96.25 -71.23, -179.32 304.54, 85.44 -93.8, 149.18 in-out in 9.2965 Saltbr-out 3.9379 HRD-in -77.72, -47.19 81.78, -30.3 out-out-out SNCooo out-out ActLoopNT-out 8.3976 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioo APE10-dihe-na -85.06, 132.75 APE9-dihe-na 75.21, 146.99 APE8-dihe-out 119.98, 103.46 APE8-rot-in 302.55 APE67-dihe-out 103.66, -39.72 -131.02, -136.12 APE12-dist-in 9.4331 APE11-dist-in 13.4939 APE10-dist-out 16.5523 APE9-dist-out 13.5575 None None None XRAY 2.6 0.202 0.254 AAA 359.0 349.0 0 25 25 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R90A P47811 4 352 360.0 SNJ:401 Type1 Inactive DFGin 7.6678 17.1876 BLBminus -137.94, -179.67 55.83, 58.82 -58.12, 146.21 285.38, 69.63 -67.29, 110.69 in-in in 9.6857 Saltbr-in 2.7825 HRD-in -71.16, -54.19 86.61, -16.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.9, 133.58 APE9-dihe-na -63.36, -19.08 APE8-dihe-out -63.12, -16.3 APE8-rot-out 58.59 APE67-dihe-in -65.84, -19.02 -114.37, -18.56 APE12-dist-out 22.0506 APE11-dist-out 24.1928 APE10-dist-out 18.4205 APE9-dist-out 11.7021 None None None XRAY 1.619 0.184 0.198 A 360.0 342.0 7 25 23 2 [[24, 308]] 1.0 5r90 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R91A P47811 5 352 360.0 SNV:401 Type1 Inactive DFGin 7.6892 17.1017 BLBminus -138.11, -177.81 53.58, 59.52 -57.75, 148.02 285.48, 71.66 -68.32, 105.39 in-in in 9.8399 Saltbr-in 2.7668 HRD-in -70.49, -52.89 81.31, -9.72 in-out-out SNCioo out-out ActLoopNT-out 10.9195 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 133.54 APE9-dihe-na -65.2, -19.43 APE8-dihe-out -60.64, -19.49 APE8-rot-out 50.11 APE67-dihe-in -65.3, -20.01 -110.38, -17.53 APE12-dist-out 22.3332 APE11-dist-out 24.4377 APE10-dist-out 18.6723 APE9-dist-out 11.8048 None None None XRAY 1.731 0.179 0.197 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r91 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R92A P47811 4 352 360.0 SO7:401 Type1 Inactive DFGin 7.5236 16.8486 BLBminus -127.62, 174.22 55.6, 60.05 -58.63, 146.88 285.47, 71.59 -64.4, 110.17 in-in in 9.6359 Saltbr-in 2.7009 HRD-in -71.14, -53.35 82.46, -11.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.37, 133.3 APE9-dihe-na -64.94, -17.52 APE8-dihe-out -63.53, -14.79 APE8-rot-out 55.16 APE67-dihe-in -64.99, -20.47 -115.68, -17.83 APE12-dist-out 22.0338 APE11-dist-out 24.1639 APE10-dist-out 18.3837 APE9-dist-out 11.7603 None None None XRAY 1.66 0.183 0.205 A 360.0 345.0 4 25 23 2 [[24, 308]] 1.0 5r92 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R99A P47811 5 352 360.0 SU7:401 Type1 Inactive DFGin 7.8919 17.0151 BLBminus -146.47, -177.12 52.77, 56.64 -55.85, 150.41 288.84, 66.98 -63.34, 105.63 in-in in 9.7647 Saltbr-in 2.7742 HRD-in -68.42, -53.33 83.16, -8.93 in-out-out SNCioo out-out ActLoopNT-out 10.9625 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.99, 135.36 APE9-dihe-na -67.72, -15.25 APE8-dihe-out -63.51, -18.59 APE8-rot-out 52.29 APE67-dihe-in -68.76, -20.75 -110.99, -17.46 APE12-dist-out 22.3537 APE11-dist-out 24.4662 APE10-dist-out 18.7111 APE9-dist-out 11.8436 None None None XRAY 1.89 0.18 0.206 A 360.0 344.0 4 25 25 0 [[24, 308]] 1.0 5r99 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9CA P47811 5 352 360.0 7ZC:401 Type1 Inactive DFGin 7.5773 17.1293 BLBminus -141.23, -179.44 54.44, 56.72 -53.76, 145.23 285.6, 70.26 -70.39, 113.88 in-in in 9.8675 Saltbr-in 2.8998 HRD-in -71.35, -53.13 82.1, -11.29 in-out-out SNCioo out-out ActLoopNT-out 10.3545 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.84, 135.25 APE9-dihe-na -67.14, -15.45 APE8-dihe-out -63.46, -16.84 APE8-rot-out 55.99 APE67-dihe-in -63.3, -20.21 -113.78, -20.26 APE12-dist-out 21.9461 APE11-dist-out 24.1229 APE10-dist-out 18.3797 APE9-dist-out 11.7482 None None None XRAY 1.74 0.192 0.213 A 360.0 347.0 1 25 25 0 [[24, 308]] 1.0 5r9c Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9FA P47811 5 352 360.0 SQP:401 Type1 Inactive DFGin 7.577 17.2001 BLBminus -138.11, -177.8 54.45, 59.57 -54.39, 144.45 283.25, 74.16 -72.98, 105.78 in-in in 9.9225 Saltbr-in 2.8257 HRD-in -69.53, -50.61 81.72, -13.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.86, 133.81 APE9-dihe-na -67.51, -18.17 APE8-dihe-out -65.56, -14.21 APE8-rot-out 67.06 APE67-dihe-in -66.44, -16.84 -108.39, -19.86 APE12-dist-out 22.2441 APE11-dist-out 24.319 APE10-dist-out 18.5556 APE9-dist-out 11.813 None None None XRAY 1.986 0.177 0.199 A 360.0 345.0 3 25 24 1 [[24, 308]] 1.0 5r9f Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9IA P47811 5 352 360.0 SQY:401 Type1 Inactive DFGin 7.6506 16.7346 BLBminus -138.77, -175.92 52.06, 60.96 -58.66, 151.66 285.82, 66.28 -70.04, 105.31 in-in in 9.7286 Saltbr-in 2.7464 HRD-in -70.61, -53.18 78.34, -9.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.64, 135.26 APE9-dihe-na -64.93, -19.54 APE8-dihe-out -56.77, -20.74 APE8-rot-out 56.09 APE67-dihe-in -66.12, -19.98 -114.56, -18.68 APE12-dist-out 22.177 APE11-dist-out 24.3357 APE10-dist-out 18.5725 APE9-dist-out 11.812 None None None XRAY 1.813 0.19 0.213 A 360.0 337.0 11 25 23 2 [[24, 308]] 1.0 5r9i Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9JA P47811 4 352 360.0 LXS:401 Type1 Inactive DFGin 7.6571 17.0258 BLBminus -137.87, -174.87 52.75, 58.86 -56.97, 144.58 283.44, 74.63 -70.59, 113.99 in-in in 9.6181 Saltbr-in 2.7535 HRD-in -68.84, -53.0 82.84, -15.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.39, 133.05 APE9-dihe-na -62.87, -19.75 APE8-dihe-out -59.33, -18.78 APE8-rot-out 51.6 APE67-dihe-in -64.82, -20.61 -116.02, -18.59 APE12-dist-out 21.9424 APE11-dist-out 24.134 APE10-dist-out 18.3934 APE9-dist-out 11.6987 None None None XRAY 1.52 0.191 0.208 A 360.0 344.0 5 25 24 1 [[24, 308]] 1.0 5r9j Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9LA P47811 4 352 360.0 SRJ:401 Type1 Inactive DFGin 7.648 17.1665 BLBminus -137.24, -178.63 56.93, 57.66 -59.32, 148.24 285.59, 71.06 -65.89, 117.05 in-in in 9.8182 Saltbr-in 2.7309 HRD-in -70.18, -52.62 82.55, -14.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.15, 131.29 APE9-dihe-na -63.61, -17.95 APE8-dihe-out -62.94, -16.32 APE8-rot-out 54.19 APE67-dihe-in -65.18, -20.54 -116.22, -18.56 APE12-dist-out 22.2098 APE11-dist-out 24.3683 APE10-dist-out 18.6195 APE9-dist-out 11.7308 None None None XRAY 1.47 0.191 0.2 A 360.0 342.0 7 25 23 2 [[24, 308]] 1.0 5r9l Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9NA P47811 4 352 360.0 JFS:401 Type1 Inactive DFGin 7.2909 16.7195 BLBminus -138.51, -178.9 58.55, 56.04 -54.08, 142.66 293.5, 73.44 -65.71, 113.38 out-out out 10.0151 Saltbr-out 5.3183 HRD-in -70.07, -53.6 81.73, -12.32 out-out-out SNCooo out-out ActLoopNT-out 10.1676 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -138.19, 133.63 APE9-dihe-na -63.94, -18.01 APE8-dihe-out -64.45, -14.4 APE8-rot-out 52.46 APE67-dihe-in -66.98, -18.95 -115.67, -16.53 APE12-dist-out 22.0365 APE11-dist-out 24.2525 APE10-dist-out 18.5634 APE9-dist-out 11.8389 None None None XRAY 1.688 0.188 0.202 A 360.0 342.0 7 25 25 0 [[24, 308]] 1.0 5r9n Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9PA P47811 5 352 360.0 SFY:401 Type1 Inactive DFGin 7.6143 16.8757 BLBminus -134.95, -173.36 51.9, 61.23 -57.06, 147.19 281.19, 76.44 -71.38, 111.1 in-in in 9.7067 Saltbr-in 2.8914 HRD-in -69.15, -54.71 83.47, -8.94 in-out-out SNCioo out-out ActLoopNT-out 10.2835 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.97, 131.95 APE9-dihe-na -63.13, -23.64 APE8-dihe-out -56.65, -23.63 APE8-rot-out 53.53 APE67-dihe-in -64.7, -21.71 -111.61, -19.66 APE12-dist-out 22.1855 APE11-dist-out 24.4362 APE10-dist-out 18.6481 APE9-dist-out 11.8611 None None None XRAY 1.72 0.175 0.195 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9p Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9RA P47811 5 352 360.0 K3D:401 Type1 Inactive DFGin 7.6673 16.9236 BLBminus -129.0, -176.69 57.76, 58.0 -55.55, 141.14 284.38, 72.22 -64.01, 110.17 in-in in 9.6896 Saltbr-in 2.7508 HRD-in -70.35, -55.62 82.21, -8.65 in-out-out SNCioo out-out ActLoopNT-out 9.9925 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.16, 137.0 APE9-dihe-na -65.4, -23.34 APE8-dihe-out -58.91, -19.74 APE8-rot-out 53.94 APE67-dihe-in -66.7, -22.91 -113.45, -18.81 APE12-dist-out 22.1706 APE11-dist-out 24.3197 APE10-dist-out 18.558 APE9-dist-out 11.7424 None None None XRAY 1.76 0.184 0.208 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9r Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9YA P47811 5 352 360.0 SU7:401 Type1 Inactive DFGin 7.6107 16.7458 BLBminus -132.18, -177.15 58.83, 54.05 -56.42, 145.76 286.43, 69.73 -66.03, 113.41 in-in in 9.6217 Saltbr-in 2.7825 HRD-in -69.32, -54.06 79.79, -4.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.67, 132.15 APE9-dihe-na -60.68, -23.39 APE8-dihe-out -59.13, -20.87 APE8-rot-out 48.76 APE67-dihe-in -63.42, -22.61 -113.67, -21.11 APE12-dist-out 22.1602 APE11-dist-out 24.3308 APE10-dist-out 18.5042 APE9-dist-out 11.7642 None None None XRAY 1.57 0.191 0.21 A 360.0 343.0 5 25 23 2 [[24, 308]] 1.0 5r9y Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA0A P47811 5 352 360.0 JFS:401 Type1 Inactive DFGin 7.3881 16.6282 BLBminus -139.8, -179.89 61.67, 49.29 -47.07, 133.74 290.08, 80.21 -62.39, 114.23 in-out in 9.9582 Saltbr-out 3.6218 HRD-in -63.09, -59.13 79.95, -2.63 out-out-out SNCooo out-out ActLoopNT-out 10.1829 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.61, 135.91 APE9-dihe-na -61.52, -28.35 APE8-dihe-out -56.52, -21.44 APE8-rot-out 43.53 APE67-dihe-in -59.92, -23.96 -112.03, -20.42 APE12-dist-out 22.0698 APE11-dist-out 24.3591 APE10-dist-out 18.6303 APE9-dist-out 11.8176 None None None XRAY 1.91 0.221 0.257 A 360.0 345.0 3 25 25 0 [[24, 308]] 1.0 5ra0 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA2A P47811 5 352 360.0 SV4:401 Type1 Inactive DFGin 7.3562 16.6064 BLBminus -133.83, -175.71 56.35, 56.82 -54.49, 147.53 281.75, 74.23 -71.39, 117.12 in-in in 9.6168 Saltbr-in 2.8915 HRD-in -69.98, -52.36 81.07, -5.94 in-out-out SNCioo out-out ActLoopNT-out 10.3532 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 129.32 APE9-dihe-na -60.35, -23.28 APE8-dihe-out -58.5, -19.86 APE8-rot-out 51.08 APE67-dihe-in -65.0, -18.22 -114.68, -19.44 APE12-dist-out 22.0844 APE11-dist-out 24.3177 APE10-dist-out 18.5372 APE9-dist-out 11.8258 None None None XRAY 1.57 0.181 0.197 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra2 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA6A P47811 5 352 360.0 SVM:401 Type1 Inactive DFGin 7.5889 16.0324 BLBminus -139.6, -174.08 52.01, 57.31 -49.9, 142.73 286.08, 73.95 -66.7, 117.63 in-in in 9.2467 Saltbr-in 3.0371 HRD-in -68.79, -56.26 81.52, -15.74 in-out-out SNCioo out-out ActLoopNT-out 10.6264 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.89, 133.47 APE9-dihe-na -60.81, -24.0 APE8-dihe-out -60.22, -21.55 APE8-rot-out 52.3 APE67-dihe-in -65.92, -20.79 -111.03, -20.17 APE12-dist-out 22.1965 APE11-dist-out 24.3921 APE10-dist-out 18.6186 APE9-dist-out 11.8294 None None None XRAY 1.86 0.185 0.211 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra6 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPB P47811 4 353 360.0 SB4:401 Type1 Inactive DFGin 7.8789 16.3745 BLBminus -134.89, -174.36 58.03, 55.66 -54.0, 135.64 290.0, 65.54 -94.36, 162.11 in-in in 9.4514 Saltbr-in 2.6901 HRD-in -69.75, -47.82 68.57, -12.57 in-out-out SNCioo out-out ActLoopNT-out 10.1643 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.51, -58.02 APE9-dihe-na -61.88, -35.33 APE8-dihe-out -56.88, -41.69 APE8-rot-in 289.42 APE67-dihe-in -68.96, -24.95 -50.74, -35.93 APE12-dist-in 11.7137 APE11-dist-in 11.2256 APE10-dist-out 16.2318 APE9-dist-out 10.7437 None None None XRAY 2.049 0.228 0.188 B 361.0 350.0 0 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPC P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 7.7603 16.3394 BLBminus -138.68, -179.91 58.54, 57.09 -52.32, 141.55 291.05, 61.14 -104.09, 166.76 in-in in 9.394 Saltbr-in 2.6296 HRD-in -64.21, -53.16 81.3, -13.91 in-out-out SNCioo out-out ActLoopNT-out 10.4136 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -64.28, -49.56 APE9-dihe-na -71.52, -38.16 APE8-dihe-out -51.64, -44.73 APE8-rot-in 286.45 APE67-dihe-in -62.39, -31.11 -56.8, -34.2 APE12-dist-in 11.7581 APE11-dist-in 11.1864 APE10-dist-out 16.1472 APE9-dist-out 10.5473 None None None XRAY 2.049 0.228 0.188 C 361.0 341.0 10 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQA P47811 3 354 360.0 SB4:401 Type1 Inactive DFGin 8.0914 16.5138 BLBminus -141.84, 179.49 59.16, 69.82 -70.4, 139.6 288.89, 66.48 -101.36, 159.57 in-in in 9.448 Saltbr-in 2.4527 HRD-in -63.24, -57.34 88.41, -26.01 in-out-out SNCioo out-out ActLoopNT-out 9.6357 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -73.62, -46.85 APE9-dihe-na -75.71, -36.69 APE8-dihe-out -50.54, -37.31 APE8-rot-in 285.03 APE67-dihe-in -71.18, -20.34 -59.58, -32.47 APE12-dist-in 12.3242 APE11-dist-in 11.7871 APE10-dist-out 16.5681 APE9-dist-out 10.7936 None None None XRAY 2.319 0.291 0.236 A 361.0 352.0 0 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQB P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 7.8608 16.4006 BLBminus -142.86, 179.87 59.5, 70.14 -71.25, 135.97 289.99, 66.27 -95.3, 157.33 in-in in 9.4879 Saltbr-in 2.4264 HRD-in -64.66, -55.98 86.54, -20.06 in-out-out SNCioo out-out ActLoopNT-out 9.7138 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -75.32, -49.2 APE9-dihe-na -70.98, -42.84 APE8-dihe-out -44.43, -42.98 APE8-rot-in 289.25 APE67-dihe-in -71.01, -21.66 -60.96, -27.97 APE12-dist-in 12.2296 APE11-dist-in 11.6993 APE10-dist-out 16.5334 APE9-dist-out 10.8468 None None None XRAY 2.319 0.291 0.236 B 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQC P47811 4 353 360.0 SB4:401 Type1 Inactive DFGin 7.9346 16.4509 BLBminus -143.64, -179.12 58.91, 71.41 -71.13, 135.9 289.34, 66.9 -100.37, 152.54 in-in in 9.454 Saltbr-in 2.4434 HRD-in -65.05, -60.56 91.58, -20.02 in-out-out SNCioo out-out ActLoopNT-out 9.6801 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -77.12, -46.24 APE9-dihe-na -71.56, -37.42 APE8-dihe-out -50.1, -40.93 APE8-rot-in 287.94 APE67-dihe-in -67.77, -24.08 -57.92, -34.79 APE12-dist-in 12.1975 APE11-dist-in 11.6785 APE10-dist-out 16.5514 APE9-dist-out 10.668 None None None XRAY 2.319 0.291 0.236 C 361.0 337.0 13 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOQD P47811 4 354 360.0 SB4:401 Type1 Inactive DFGin 7.9252 16.3392 BLBminus -137.78, -176.18 55.52, 70.52 -70.14, 135.43 292.15, 66.71 -98.76, 156.08 in-in in 9.5121 Saltbr-in 2.4763 HRD-in -69.33, -57.76 89.49, -22.47 in-out-out SNCioo out-out ActLoopNT-out 9.7908 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -75.18, -46.22 APE9-dihe-na -71.04, -39.79 APE8-dihe-out -50.99, -35.23 APE8-rot-in 287.27 APE67-dihe-in -69.51, -20.49 -61.37, -33.69 APE12-dist-in 12.2648 APE11-dist-in 11.7656 APE10-dist-out 16.5713 APE9-dist-out 10.6883 None None None XRAY 2.319 0.291 0.236 D 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4loq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8UA P47811 5 352 360.0 SLS:401 Type1.5_Back Inactive DFGin 7.9973 16.7294 BLBminus -114.75, 170.33 94.23, 75.22 -129.34, 124.66 295.54, 92.34 76.49, 17.64 in-in in 9.3283 Saltbr-in 2.8371 HRD-in -74.34, -52.41 80.29, -13.59 in-out-out SNCioo out-out ActLoopNT-out 11.0433 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -135.11, 132.18 APE9-dihe-na -60.6, -25.64 APE8-dihe-out -66.72, -13.83 APE8-rot-in 303.39 APE67-dihe-in -64.83, -21.18 -106.8, -21.17 APE12-dist-out 21.8654 APE11-dist-out 23.6946 APE10-dist-out 17.8181 APE9-dist-out 11.3763 None None None XRAY 1.48 0.181 0.198 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r8u Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA7A P47811 5 352 360.0 SW7:401 Type1.5_Back Inactive DFGin 7.8717 16.8284 BLBminus -109.87, 168.39 99.38, 71.14 -119.28, 122.94 290.21, 91.33 72.87, 24.0 in-in in 9.3529 Saltbr-in 3.1224 HRD-in -67.43, -52.94 77.22, -9.02 in-out-out SNCioo out-out ActLoopNT-out 11.3078 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.7, 133.67 APE9-dihe-na -56.89, -35.11 APE8-dihe-out -58.78, -22.98 APE8-rot-out 50.89 APE67-dihe-in -63.4, -23.94 -102.22, -22.93 APE12-dist-out 21.9431 APE11-dist-out 23.7872 APE10-dist-out 17.8834 APE9-dist-out 11.6895 None None None XRAY 1.92 0.18 0.209 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra7 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA8A P47811 5 352 360.0 2O6:401 Type1.5_Back Inactive DFGin 8.0262 17.03 BLBminus -107.95, 170.65 89.03, 79.85 -127.96, 127.66 291.36, 90.97 75.31, 22.6 in-in in 9.2733 Saltbr-in 2.8891 HRD-in -68.33, -55.58 80.75, -13.24 in-out-out SNCioo out-out ActLoopNT-out 11.2235 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.91, 134.0 APE9-dihe-na -63.22, -27.25 APE8-dihe-out -60.6, -13.44 APE8-rot-out 50.23 APE67-dihe-in -63.41, -23.94 -112.77, -25.02 APE12-dist-out 22.0108 APE11-dist-out 23.8485 APE10-dist-out 17.9216 APE9-dist-out 11.5735 None None None XRAY 1.78 0.183 0.21 A 360.0 344.0 4 25 25 0 [[24, 308]] 1.0 5ra8 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8YA P47811 4 352 360.0 SMV:401 Type3 Inactive DFGin 7.9 16.7927 BLBminus -115.18, 174.46 86.01, 79.12 -130.02, 131.19 294.34, 93.85 77.63, 13.6 in-in in 9.45 Saltbr-in 2.815 HRD-in -72.91, -49.09 80.16, -14.98 in-out-out SNCioo out-out ActLoopNT-out 11.08 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.04, 132.68 APE9-dihe-na -64.1, -21.25 APE8-dihe-out -66.93, -11.24 APE8-rot-out 49.29 APE67-dihe-in -64.72, -20.5 -110.83, -19.65 APE12-dist-out 21.8896 APE11-dist-out 23.669 APE10-dist-out 17.819 APE9-dist-out 11.5053 None None None XRAY 1.679 0.179 0.198 A 360.0 346.0 3 25 25 0 [[24, 308]] 1.0 5r8y Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R8ZA P47811 5 352 360.0 SN4:401 Type3 Inactive DFGin 8.0828 16.7805 BLBminus -109.77, 173.86 86.86, 76.26 -126.38, 131.11 295.21, 88.72 77.15, 15.55 in-in in 9.4374 Saltbr-in 2.7482 HRD-in -74.55, -50.34 76.91, -8.98 in-out-out SNCioo out-out ActLoopNT-out 10.8682 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.11, 136.4 APE9-dihe-na -65.57, -21.76 APE8-dihe-out -71.02, -4.43 APE8-rot-out 44.37 APE67-dihe-in -63.83, -21.68 -115.56, -21.67 APE12-dist-out 21.944 APE11-dist-out 23.7604 APE10-dist-out 17.9214 APE9-dist-out 11.3284 None None None XRAY 1.65 0.181 0.194 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r8z Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R97A P47811 5 352 360.0 RUY:401 Type3 Inactive DFGin 8.0523 16.7857 BLBminus -107.35, 174.0 88.72, 75.58 -129.06, 130.07 292.0, 84.81 76.81, 15.71 in-in in 9.1352 Saltbr-in 2.8616 HRD-in -73.91, -50.02 78.62, -14.33 in-out-out SNCioo out-out ActLoopNT-out 11.0059 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.66, 133.31 APE9-dihe-na -61.73, -24.21 APE8-dihe-out -70.48, -5.0 APE8-rot-out 35.58 APE67-dihe-in -62.43, -22.92 -114.02, -22.54 APE12-dist-out 21.9711 APE11-dist-out 23.7783 APE10-dist-out 17.9284 APE9-dist-out 11.3993 None None None XRAY 1.438 0.178 0.187 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r97 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9DA P47811 5 352 360.0 N9J:401 Type3 Inactive DFGin 6.9061 16.2906 BLBminus -142.84, -177.62 59.46, 54.53 -49.92, 143.22 293.02, 81.79 -67.58, 124.55 in-in in 9.6071 Saltbr-in 2.7075 HRD-in -71.3, -52.07 83.51, -18.96 in-out-out SNCioo out-out ActLoopNT-out 10.6598 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.54, 137.09 APE9-dihe-na -66.35, -15.51 APE8-dihe-out -64.24, -16.61 APE8-rot-out 49.12 APE67-dihe-in -64.38, -19.38 -115.02, -18.09 APE12-dist-out 21.6518 APE11-dist-out 23.9196 APE10-dist-out 18.2348 APE9-dist-out 11.8414 None None None XRAY 1.69 0.192 0.213 A 360.0 344.0 4 25 25 0 [[24, 308]] 1.0 5r9d Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9EA P47811 5 352 360.0 S7S:401 Type3 Inactive DFGin 7.6744 17.2716 BLBminus -137.39, 179.1 57.74, 56.07 -53.7, 142.45 286.41, 71.06 -68.12, 115.34 in-in in 9.9193 Saltbr-in 2.8383 HRD-in -69.03, -54.62 82.77, -10.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.87, 136.52 APE9-dihe-na -64.45, -18.37 APE8-dihe-out -63.84, -12.84 APE8-rot-out 48.2 APE67-dihe-in -64.03, -22.32 -118.18, -18.76 APE12-dist-out 22.0535 APE11-dist-out 24.2243 APE10-dist-out 18.501 APE9-dist-out 11.8396 None None None XRAY 1.775 0.192 0.212 A 360.0 345.0 3 25 24 1 [[24, 308]] 1.0 5r9e Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9KA P47811 4 352 360.0 SR4:401 Type3 Inactive DFGin 7.9752 16.6643 BLBminus -109.17, 173.51 89.46, 74.18 -129.95, 129.84 290.88, 85.94 81.01, 12.12 in-in in 9.27 Saltbr-in 2.8652 HRD-in -71.68, -50.3 79.29, -13.82 in-out-out SNCioo out-out ActLoopNT-out 10.7713 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.69, 132.06 APE9-dihe-na -61.92, -24.83 APE8-dihe-out -67.69, -6.53 APE8-rot-out 49.1 APE67-dihe-in -65.36, -21.0 -113.73, -21.26 APE12-dist-out 21.8145 APE11-dist-out 23.6535 APE10-dist-out 17.818 APE9-dist-out 11.3684 None None None XRAY 1.498 0.19 0.201 A 360.0 343.0 6 25 25 0 [[24, 308]] 1.0 5r9k Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9QA P47811 5 352 360.0 LVD:401 Type3 Inactive DFGin 8.1877 17.0637 BLBminus -112.14, 170.23 80.58, 82.07 -125.39, 129.02 290.8, 89.76 79.27, 13.12 in-in in 9.66 Saltbr-in 2.7687 HRD-in -79.07, -52.75 78.49, -13.32 in-out-out SNCioo out-out ActLoopNT-out 11.7684 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 130.81 APE9-dihe-na -62.18, -18.13 APE8-dihe-out -61.69, -16.69 APE8-rot-out 55.26 APE67-dihe-in -64.61, -20.41 -115.23, -19.01 APE12-dist-out 21.8683 APE11-dist-out 23.655 APE10-dist-out 17.8123 APE9-dist-out 11.6255 None None None XRAY 1.645 0.211 0.229 A 360.0 346.0 2 25 25 0 [[24, 308]] 1.0 5r9q Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9WA P47811 5 352 360.0 STV:401 Type3 Inactive DFGin 7.6564 16.9506 BLBminus -134.85, -175.6 55.42, 59.11 -52.2, 138.85 288.54, 71.33 -68.06, 113.57 in-in in 9.773 Saltbr-in 2.8469 HRD-in -67.37, -56.08 84.96, -12.7 in-out-out SNCioo out-out ActLoopNT-out 10.0754 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.6, 135.98 APE9-dihe-na -66.18, -24.11 APE8-dihe-out -59.13, -22.75 APE8-rot-out 55.31 APE67-dihe-in -66.54, -23.46 -107.25, -17.91 APE12-dist-out 22.2417 APE11-dist-out 24.4104 APE10-dist-out 18.6084 APE9-dist-out 11.7572 None None None XRAY 1.89 0.176 0.204 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9w Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA1A P47811 5 352 360.0 PO6:401 Type3 Inactive DFGin 8.0317 16.9673 BLBminus -116.6, 170.37 81.52, 81.7 -127.11, 124.0 290.13, 89.2 75.77, 17.38 in-in in 9.5985 Saltbr-in 2.7673 HRD-in -67.99, -54.24 81.95, -19.51 in-out-out SNCioo out-out ActLoopNT-out 11.3297 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 131.95 APE9-dihe-na -63.72, -22.68 APE8-dihe-out -62.28, -13.71 APE8-rot-out 51.04 APE67-dihe-in -62.19, -23.02 -116.68, -25.26 APE12-dist-out 21.9817 APE11-dist-out 23.8091 APE10-dist-out 17.9257 APE9-dist-out 11.4782 None None None XRAY 1.61 0.188 0.213 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra1 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5RA9A P47811 5 352 360.0 SWD:401 Type3 Inactive DFGin 7.838 16.6064 BLBminus -112.11, 165.99 91.45, 84.17 -130.08, 120.06 293.76, 89.11 79.19, 18.98 in-in in 9.4222 Saltbr-in 3.02 HRD-in -67.29, -51.81 76.3, -9.73 in-out-out SNCioo out-out ActLoopNT-out 11.0523 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.19, 133.7 APE9-dihe-na -64.27, -25.04 APE8-dihe-out -60.75, -16.06 APE8-rot-out 55.77 APE67-dihe-in -64.26, -22.13 -114.22, -21.12 APE12-dist-out 21.9486 APE11-dist-out 23.8109 APE10-dist-out 17.9369 APE9-dist-out 11.5975 None None None XRAY 1.68 0.185 0.201 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5ra9 Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7Z9TBBB P47811 4 353 360.0 87B:401,ATP:402 Type3,Allosteric Inactive DFGin 5.8293 15.2444 BLBminus -103.34, -178.81 25.47, 89.69 -68.87, -161.65 315.54, 109.9 -76.7, 116.65 out-out out 10.3417 Saltbr-out 4.1791 HRD-in -67.82, -70.27 93.09, -17.91 out-out-out SNCooo out-out ActLoopNT-out 7.706 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -124.01, -67.71 APE9-dihe-na -98.04, -13.3 APE8-dihe-out -67.58, -39.12 APE8-rot-in 311.0 APE67-dihe-in -63.55, -21.3 -74.81, -8.77 APE12-dist-out 14.5958 APE11-dist-out 16.3559 APE10-dist-out 19.3522 APE9-dist-out 12.5383 None None None XRAY 2.6 0.202 0.254 BBB 359.0 350.0 0 25 25 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7ZA P47811 5 359 360.0 OG2:401,SB4:402 Allosteric,Type1 Inactive DFGin 5.8047 14.0802 BLBplus -134.49, 165.73 62.07, 30.36 -82.63, 160.92 45.56, 91.95 67.74, 16.55 in-in in 9.0911 Saltbr-in 2.6363 HRD-in -77.23, -57.59 79.7, -16.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -109.25, 119.36 APE9-dihe-na -93.25, 151.32 APE8-dihe-in -67.43, 140.14 APE8-rot-in 312.96 APE67-dihe-in -62.55, -20.7 -109.35, 3.64 APE12-dist-none 999.0 APE11-dist-out 14.3829 APE10-dist-out 17.8776 APE9-dist-out 10.7115 C162S None None XRAY 1.35 0.206 0.221 A 360.0 345.0 10 25 15 10 [[24, 308]] 1.0 6y7z Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y80A P47811 5 359 360.0 OFZ:401,SB4:402 Allosteric,Type1 Inactive DFGin 5.7992 14.0377 BLBplus -138.73, 168.62 61.09, 29.77 -83.59, 159.45 46.06, 90.54 66.98, 15.27 in-in in 9.087 Saltbr-in 2.665 HRD-in -74.85, -59.95 82.11, -13.42 in-out-out SNCioo out-out ActLoopNT-out 9.6978 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -117.02, 118.3 APE9-dihe-na -92.88, 152.22 APE8-dihe-in -67.79, 140.44 APE8-rot-in 312.07 APE67-dihe-in -64.09, -20.28 -111.17, 5.5 APE12-dist-none 999.0 APE11-dist-out 14.1846 APE10-dist-out 17.7618 APE9-dist-out 10.6436 C162S None None XRAY 1.24 0.211 0.225 A 360.0 347.0 8 25 17 8 [[24, 308]] 1.0 6y80 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y85A P47811 5 359 360.0 OG8:401,SB4:402 Allosteric,Type1 Inactive DFGin 5.7885 14.0002 BLBplus -133.77, 163.81 63.67, 30.98 -81.27, 159.22 44.79, 91.89 66.91, 14.74 in-in in 9.1062 Saltbr-in 2.6334 HRD-in -79.67, -55.49 77.93, -17.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 122.52 APE9-dihe-na -99.2, 150.85 APE8-dihe-in -73.53, 136.09 APE8-rot-out 184.17 APE67-dihe-in -61.9, -19.08 -104.49, 5.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.7913 APE9-dist-out 10.7698 C162S None None XRAY 1.58 0.203 0.233 A 360.0 344.0 11 25 14 11 [[24, 308]] 1.0 6y85 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1YWRA P47811 5 352 360.0 LI9:361 Type1 Inactive DFGin 5.2108 13.9496 BLBplus -116.71, 157.04 59.91, 27.05 -73.95, 150.06 44.11, 88.12 64.26, 12.6 in-in in 9.1159 Saltbr-in 2.8598 HRD-in -70.15, -61.76 83.18, -15.96 in-out-out SNCioo out-out ActLoopNT-out 6.7427 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -48.34 APE9-dihe-na -66.85, 129.84 APE8-dihe-out -48.26, -56.45 APE8-rot-in 267.39 APE67-dihe-in -58.06, -30.9 -49.13, -36.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.5909 APE9-dist-out 11.2889 T180A,Y182F None None XRAY 1.95 0.221 999.0 A 360.0 338.0 10 25 16 9 [[24, 308]] 1.0 1ywr Mus musculus CMGC_MAPK14_MOUSE CMGC 5.7e-84 287.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GHLA P47811 5 352 360.0 LIB:401 Type1 Inactive DFGin 5.9959 13.5411 BLBplus -97.83, 160.0 59.37, 11.56 -48.09, 172.67 29.98, 90.0 61.12, 163.68 in-in in 9.1546 Saltbr-in 2.7617 HRD-in -68.51, -51.08 75.63, -16.1 in-out-out SNCioo out-out ActLoopNT-out 7.3922 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.45 APE8-dihe-out -59.27, -35.78 APE8-rot-in 257.99 APE67-dihe-in -62.7, -29.84 -59.27, -22.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0703 T180A,Y182F None None XRAY 2.099 0.22 0.301 A 348.0 334.0 14 25 15 10 [[24, 308]] 1.0 2ghl Mus musculus CMGC_MAPK14_MOUSE CMGC 6.3e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7PVUB P47811 5 353 360.0 8DI:401 Type1 Inactive DFGin 4.7753 13.4884 BLBplus -105.43, 149.04 51.46, 91.1 -127.89, 139.29 40.85, 75.02 77.85, 16.27 in-out in 9.3171 Saltbr-out 4.8669 HRD-in -70.68, -50.64 86.9, -39.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.21, -24.31 999.0, -41.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.154 0.207 0.239 B 359.0 336.0 13 25 12 13 [[24, 308]] 1.0 7pvu Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y8HA P47811 6 359 360.0 SB4:401 Type1 Inactive DFGin 5.8151 14.0537 BLBplus -135.21, 165.85 62.02, 30.41 -83.55, 158.25 44.85, 92.38 64.97, 19.96 in-in in 9.072 Saltbr-in 2.6287 HRD-in -77.67, -57.36 79.23, -15.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -117.79, 112.37 APE9-dihe-na -86.44, 149.11 APE8-dihe-in -71.62, 140.44 APE8-rot-out 186.93 APE67-dihe-in -64.36, -20.23 -106.31, 4.54 APE12-dist-none 999.0 APE11-dist-out 14.2864 APE10-dist-out 17.8292 APE9-dist-out 10.6582 C162S None None XRAY 1.37 0.22 0.24 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6y8h Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8ACMAAA P47811 4 353 360.0 SB2:404 Type1 Inactive DFGin 4.9736 13.5759 BLBplus -133.06, 172.45 65.93, 40.39 -104.24, 158.57 46.44, 78.55 74.47, 13.2 in-in in 9.2831 Saltbr-in 2.733 HRD-in -64.79, -58.1 86.27, -19.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -80.81 APE8-rot-out 32.52 APE67-dihe-in -67.54, -28.38 -107.69, -1.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.203 0.244 AAA 359.0 337.0 13 25 12 13 [[24, 308]] 1.0 8acm Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOOA P47811 5 353 360.0 SB4:401 Type1 Inactive DFGin 5.1652 13.6397 BLBplus -138.69, 175.26 57.38, 21.13 -65.41, 148.91 40.93, 100.05 58.84, 14.22 in-in in 9.4468 Saltbr-in 2.7407 HRD-in -67.27, -58.36 82.42, -11.86 in-out-out SNCioo out-out ActLoopNT-out 7.805 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -69.7, -42.51 APE9-dihe-na -65.22, -44.97 APE8-dihe-out -51.84, -47.66 APE8-rot-in 295.05 APE67-dihe-in -57.54, -26.2 -56.34, -38.54 APE12-dist-in 13.22 APE11-dist-out 14.0915 APE10-dist-out 18.2412 APE9-dist-out 10.5624 None None None XRAY 1.95 0.241 0.25 A 361.0 349.0 0 25 25 0 [[24, 308]] 1.0 4loo Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPA P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 4.9871 13.5854 BLBplus -129.95, 174.57 59.37, 38.27 -78.72, 134.12 36.97, 91.41 61.45, 25.3 in-in in 9.3588 Saltbr-in 2.6652 HRD-in -71.62, -51.29 83.15, -21.15 in-out-out SNCioo out-out ActLoopNT-out 9.2801 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.82, -52.38 APE9-dihe-na -68.84, -35.89 APE8-dihe-out -58.52, -41.68 APE8-rot-in 287.8 APE67-dihe-in -57.4, -27.72 -51.64, -45.15 APE12-dist-in 12.9714 APE11-dist-out 14.1938 APE10-dist-out 18.3542 APE9-dist-out 10.6314 None None None XRAY 2.049 0.228 0.188 A 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 4LOPD P47811 3 353 360.0 SB4:401 Type1 Inactive DFGin 5.2292 13.7485 BLBplus -121.46, 170.78 65.92, 32.28 -73.43, 136.83 36.96, 89.29 68.77, 15.79 in-in in 9.3311 Saltbr-in 2.3969 HRD-in -63.28, -51.2 80.67, -15.6 in-out-out SNCioo out-out ActLoopNT-out 9.0273 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -67.14, -56.19 APE9-dihe-na -62.79, -36.04 APE8-dihe-out -60.71, -35.02 APE8-rot-in 289.55 APE67-dihe-in -68.29, -24.83 -59.29, -35.33 APE12-dist-in 13.1326 APE11-dist-out 14.63 APE10-dist-out 18.7219 APE9-dist-out 10.6414 None None None XRAY 2.049 0.228 0.188 D 361.0 351.0 0 25 25 0 [[24, 308]] 1.0 4lop Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5O90A P47811 5 353 360.0 SB4:60401 Type1 Inactive DFGin 5.4528 13.7859 BLBplus -138.77, 169.02 69.52, 19.52 -71.52, 150.78 44.44, 88.51 66.51, 10.19 in-in in 8.9964 Saltbr-in 2.1227 HRD-in -58.31, -66.83 71.21, -2.15 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nooo APE10-dihe-na -66.12, -47.79 APE9-dihe-na -59.74, -42.18 APE8-dihe-out -59.22, -24.24 APE8-rot-none 999.0 APE67-dihe-in -69.19, -25.86 -58.58, -27.59 APE12-dist-none 999.0 APE11-dist-out 14.1867 APE10-dist-out 18.6192 APE9-dist-out 11.8699 T185G None None XRAY 2.49 0.25 0.275 A 360.0 330.0 19 25 16 9 [[24, 308]] 1.0 5o90 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.8e-84 288.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7WA P47811 6 359 360.0 SB4:401,OFW:407 Type1,Allosteric Inactive DFGin 5.7758 14.0012 BLBplus -138.18, 164.68 62.81, 30.03 -82.32, 159.35 44.93, 92.43 65.05, 18.06 in-in in 9.078 Saltbr-in 2.7148 HRD-in -76.23, -57.75 79.93, -16.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -109.65, 120.06 APE9-dihe-na -93.91, 149.55 APE8-dihe-in -73.55, 137.64 APE8-rot-out 186.72 APE67-dihe-in -61.54, -21.24 -103.29, -0.91 APE12-dist-none 999.0 APE11-dist-out 14.1674 APE10-dist-out 17.7506 APE9-dist-out 10.6882 C162S None None XRAY 1.39 0.196 0.219 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6y7w Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7XA P47811 5 359 360.0 SB4:401,OFQ:407 Type1,Allosteric Inactive DFGin 5.8376 14.1423 BLBplus -140.52, 171.9 59.02, 32.21 -87.93, 160.25 46.31, 91.31 62.16, 18.97 in-in in 9.0815 Saltbr-in 2.6196 HRD-in -74.68, -57.27 79.25, -15.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -117.66, 121.28 APE9-dihe-na -97.49, 147.27 APE8-dihe-in -70.48, 139.23 APE8-rot-out 189.8 APE67-dihe-in -64.63, -20.63 -107.94, 3.51 APE12-dist-none 999.0 APE11-dist-out 14.2773 APE10-dist-out 17.7869 APE9-dist-out 10.699 C162S None None XRAY 1.45 0.211 0.229 A 360.0 345.0 10 25 15 10 [[24, 308]] 1.0 6y7x Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y81A P47811 6 359 360.0 SB4:401,OG5:412 Type1,Allosteric Inactive DFGin 5.7123 14.0382 BLBplus -134.64, 167.76 60.96, 33.88 -85.35, 157.58 46.03, 92.46 64.9, 14.25 in-in in 9.057 Saltbr-in 2.65 HRD-in -76.57, -56.48 79.55, -12.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -115.04, 120.9 APE9-dihe-na -94.31, 149.4 APE8-dihe-in -73.15, 140.45 APE8-rot-out 187.1 APE67-dihe-in -64.15, -19.25 -104.4, 0.89 APE12-dist-none 999.0 APE11-dist-out 14.4174 APE10-dist-out 17.8789 APE9-dist-out 10.73 C162S None None XRAY 1.54 0.196 0.216 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6y81 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y82A P47811 6 360 360.0 SB4:401,308:406 Type1,Allosteric Inactive DFGin 5.7802 14.1165 BLBplus -142.47, 171.91 59.75, 34.72 -91.59, 158.86 46.33, 90.48 63.9, 13.45 in-in in 9.0992 Saltbr-in 2.6025 HRD-in -74.39, -55.41 79.48, -17.19 in-out-out SNCioo out-out ActLoopNT-out 10.0125 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -118.57, 115.69 APE9-dihe-na -92.25, 152.14 APE8-dihe-in -74.19, 138.56 APE8-rot-out 188.04 APE67-dihe-in -61.96, -21.6 -107.94, 4.31 APE12-dist-none 999.0 APE11-dist-out 14.3499 APE10-dist-out 17.8896 APE9-dist-out 10.7463 C162S None None XRAY 1.44 0.217 0.243 A 360.0 348.0 7 25 18 7 [[24, 308]] 1.0 6y82 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YCWA P47811 6 359 360.0 SB4:401,OL8:405 Type1,Allosteric Inactive DFGin 5.709 13.9783 BLBplus -139.04, 169.42 60.88, 31.24 -83.97, 157.96 42.66, 93.01 65.82, 20.88 in-in in 9.0477 Saltbr-in 2.7268 HRD-in -76.03, -57.42 78.87, -15.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -117.62, 117.38 APE9-dihe-na -94.12, 150.56 APE8-dihe-in -63.64, 137.82 APE8-rot-in 296.65 APE67-dihe-in -63.75, -20.54 -110.36, 3.6 APE12-dist-none 999.0 APE11-dist-out 14.2316 APE10-dist-out 17.7539 APE9-dist-out 10.6885 C162S None None XRAY 1.34 0.23 0.251 A 360.0 344.0 10 25 15 10 [[24, 308]] 1.0 6ycw Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOVA P47811 6 359 360.0 SB4:401,LOT:406,LOW:407 Type1,Allosteric,Allosteric Inactive DFGin 5.7849 14.0824 BLBplus -138.85, 169.33 61.87, 30.79 -84.92, 158.4 45.37, 91.9 65.06, 17.43 in-in in 9.109 Saltbr-in 2.6841 HRD-in -76.78, -56.48 78.7, -16.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -119.14, 115.02 APE9-dihe-na -91.52, 150.5 APE8-dihe-in -73.47, 137.08 APE8-rot-out 187.92 APE67-dihe-in -63.35, -21.25 -104.06, 1.09 APE12-dist-none 999.0 APE11-dist-out 14.2686 APE10-dist-out 17.8733 APE9-dist-out 10.6949 None None None XRAY 1.31 0.222 0.236 A 361.0 345.0 9 25 16 9 [[24, 308]] 1.0 6sov Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SP9A P47811 5 359 360.0 SB4:401,LOT:407,LOT:408 Type1,Allosteric,Allosteric Inactive DFGin 5.7449 14.0248 BLBplus -140.9, 168.52 62.86, 31.59 -87.26, 153.1 44.44, 90.21 64.02, 999.0 in-in in 9.1125 Saltbr-in 2.6859 HRD-in -74.78, -57.56 80.54, -13.75 in-out-out SNCioo out-out ActLoopNT-out 10.2704 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -121.16, 112.82 APE9-dihe-na -87.42, 149.28 APE8-dihe-in -72.91, 139.05 APE8-rot-out 186.67 APE67-dihe-in -63.91, -20.89 -106.74, 1.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6765 None None None XRAY 1.22 0.221 0.235 A 361.0 348.0 7 25 18 7 [[24, 308]] 1.0 6sp9 Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y7YA P47811 6 359 360.0 SB4:401,OFQ:407,LOT:408,LOT:409 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 5.5985 14.0658 BLBplus -134.15, 167.21 61.56, 33.57 -84.2, 154.3 46.03, 91.51 71.1, 10.08 in-in in 9.0829 Saltbr-in 2.4631 HRD-in -77.03, -55.9 76.47, -10.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 124.77 APE9-dihe-na -96.71, 148.3 APE8-dihe-in -61.68, 139.31 APE8-rot-in 301.71 APE67-dihe-in -65.13, -20.59 -107.51, 1.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.6132 APE9-dist-out 10.7375 C162S None None XRAY 1.51 0.221 0.248 A 360.0 343.0 11 25 14 11 [[24, 308]] 1.0 6y7y Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SPLA P47811 6 359 360.0 SB4:401,LOW:407,LOW:408,LOW:409 Type1,Allosteric,Type1,Allosteric Inactive DFGin 5.7888 14.0854 BLBplus -138.3, 168.28 62.33, 31.95 -86.41, 154.5 45.54, 89.73 64.4, 18.17 in-in in 9.0762 Saltbr-in 2.6411 HRD-in -75.83, -58.19 80.85, -15.09 in-out-out SNCioo out-out ActLoopNT-out 9.5477 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -119.05, 110.89 APE9-dihe-na -86.15, 150.38 APE8-dihe-in -72.29, 139.09 APE8-rot-out 187.06 APE67-dihe-in -62.58, -21.12 -105.6, 1.04 APE12-dist-none 999.0 APE11-dist-out 14.3304 APE10-dist-out 17.9596 APE9-dist-out 10.672 None None None XRAY 1.38 0.212 0.225 A 361.0 345.0 9 25 16 9 [[24, 308]] 1.0 6spl Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7Z6IAAA P47811 5 354 360.0 IIM:401,87B:402 Type1,Type1 Inactive DFGin 5.0264 13.1011 BLBplus -131.93, 169.42 64.34, 26.47 -80.75, 150.18 38.76, 73.8 75.32, 1.38 in-in in 9.0659 Saltbr-in 2.8167 HRD-in -67.36, -56.38 84.82, -19.96 in-out-out SNCioo out-out ActLoopNT-out 7.604 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -134.34, 166.34 APE9-dihe-na 72.42, 10.47 APE8-dihe-out -100.2, -17.45 APE8-rot-out 95.44 APE67-dihe-in -59.29, -28.51 -61.84, -26.86 APE12-dist-out 14.4451 APE11-dist-in 12.4653 APE10-dist-out 17.6048 APE9-dist-out 11.8602 C162S None None XRAY 2.25 0.195 0.248 AAA 360.0 350.0 0 25 25 0 [[24, 308]] 1.0 7z6i Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6SOUA P47811 5 352 360.0 LPZ:406,LPZ:407 Allosteric,Type1 Inactive DFGin 7.3625 16.8084 None -133.04, -176.46 59.36, 52.66 -52.08, 999.0 288.27, 77.53 999.0, 999.0 in-in in 9.7302 Saltbr-in 2.8273 HRD-in -72.19, -51.58 83.69, -12.25 in-out-out SNCioo out-out ActLoopNT-out 12.0028 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -134.59, 133.82 APE9-dihe-na -63.41, -18.88 APE8-dihe-out -63.42, -15.13 APE8-rot-out 53.27 APE67-dihe-in -66.48, -19.16 -115.28, -17.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8872 None None None XRAY 1.5 0.216 0.233 A 381.0 342.0 6 25 22 3 [[24, 308]] 1.0 6sou Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3TG1A P47811 5 352 360.0 No_ligand No_ligand Inactive DFGin 6.8247 16.0345 None -116.32, 155.59 -1.61, 110.61 -70.76, 999.0 331.08, 173.37 999.0, 999.0 in-in in 9.7774 Saltbr-in 3.192 HRD-in -71.22, -51.39 75.49, -16.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.05 APE8-dihe-out -54.64, -33.8 APE8-rot-out 159.97 APE67-dihe-in -72.3, -17.1 -60.98, -22.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2156 None None None XRAY 2.71 0.311 0.26 A 380.0 334.0 14 25 11 14 [[24, 308]] 1.0 3tg1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.3e-85 292.5 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GHMA P47811 5 352 360.0 LIC:353 Type1 Inactive DFGin 5.7845 13.7767 None -78.81, 171.19 -55.87, 93.41 -25.52, 88.72 34.83, 93.47 -170.14, 167.5 in-in in 9.288 Saltbr-in 3.2035 HRD-in -62.78, -61.35 90.75, -25.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -53.87 APE9-dihe-na -71.96, -67.71 APE8-dihe-out -49.26, -48.1 APE8-rot-in 270.21 APE67-dihe-in -62.91, -14.17 -44.49, -46.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.3212 APE9-dist-out 11.3867 T180A,Y182F None None XRAY 2.35 0.232 0.323 A 348.0 336.0 12 25 14 11 [[24, 308]] 1.0 2ghm Mus musculus CMGC_MAPK14_MOUSE CMGC 6.3e-84 287.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 1YW2A P47811 4 353 360.0 PGJ:62001 Type1 Inactive DFGin 7.4408 13.8889 None -108.87, 130.98 -78.03, -31.11 -137.46, 121.59 317.27, 85.69 -153.54, 999.0 in-in in 9.1653 Saltbr-in 2.8889 HRD-in -65.03, -58.53 71.57, -11.34 in-out-out SNCioo out-out ActLoopNT-out 19.2412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 140.08 APE9-dihe-na -171.64, 79.36 APE8-dihe-out -4.97, -52.19 APE8-rot-out 22.63 APE67-dihe-in -78.16, -22.44 -73.05, -7.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.3444 T180A,Y182F None None XRAY 2.01 0.207 0.29 A 360.0 341.0 9 25 16 9 [[24, 308]] 1.0 1yw2 Mus musculus CMGC_MAPK14_MOUSE CMGC 7.1e-84 287.6 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GTMA P47811 5 352 360.0 LID:353 Type1 Inactive DFGin 10.5798 12.2976 None -99.42, 151.2 -66.85, -46.24 -140.98, 139.16 303.6, 104.59 -99.33, -162.53 in-in in 9.0195 Saltbr-in 2.6326 HRD-in -70.94, -57.65 84.88, -6.9 in-out-out SNCioo out-out ActLoopNT-out 21.3254 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -146.35, 106.63 APE9-dihe-na -84.71, 129.28 APE8-dihe-out -45.44, -51.38 APE8-rot-in 285.81 APE67-dihe-in -54.42, -30.85 -58.09, -32.0 APE12-dist-none 999.0 APE11-dist-in 10.9379 APE10-dist-out 9.1615 APE9-dist-out 10.8018 None None None XRAY 1.9 0.231 0.261 A 348.0 341.0 7 25 21 4 [[24, 308]] 1.0 2gtm Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2GTNA P47811 5 352 360.0 LIE:354 Type1 Inactive DFGin 10.5589 12.1049 None -97.49, 148.4 -66.36, -50.18 -132.83, 140.82 310.6, 94.93 -102.32, -165.42 in-in in 8.8869 Saltbr-in 2.5937 HRD-in -68.82, -53.97 78.95, -12.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.88 APE8-dihe-out -46.6, -50.56 APE8-rot-in 275.26 APE67-dihe-in -60.86, -30.99 -59.17, -25.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8082 None None None XRAY 1.8 0.203 0.248 A 348.0 337.0 11 25 14 11 [[24, 308]] 1.0 2gtn Mus musculus CMGC_MAPK14_MOUSE CMGC 1.7e-85 292.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8ACOAAA P47811 4 352 360.0 SB2:401 Type1 Inactive DFGin 5.7374 14.0092 None -148.97, 178.49 24.89, 96.95 -83.03, 999.0 316.51, 111.13 999.0, 999.0 in-in in 9.3324 Saltbr-in 2.582 HRD-in -68.93, -56.93 87.8, -49.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -122.76 APE8-rot-in 323.22 APE67-dihe-in -64.13, -36.89 -112.86, 8.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.212 0.278 AAA 359.0 334.0 15 25 10 15 [[24, 308]] 1.0 8aco Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5R9UA P47811 5 352 360.0 JMM:401 Type1 Inactive DFGin 7.8704 16.4146 None -105.42, 167.68 86.02, 81.87 -120.77, 999.0 293.85, 91.32 999.0, 999.0 in-in in 9.5521 Saltbr-in 2.9149 HRD-in -68.92, -55.3 81.59, -7.51 in-out-out SNCioo out-out ActLoopNT-out 10.0022 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -133.83, 134.83 APE9-dihe-na -63.75, -21.85 APE8-dihe-out -58.31, -17.35 APE8-rot-out 54.12 APE67-dihe-in -65.05, -20.74 -118.93, -19.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6787 None None None XRAY 1.67 0.187 0.213 A 360.0 345.0 3 25 22 3 [[24, 308]] 1.0 5r9u Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8EFJA P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.6842 15.1508 None -107.83, -138.53 -47.2, 131.52 -82.89, 153.62 283.8, 59.38 -72.43, 123.55 in-in in 9.147 Saltbr-in 2.8713 HRD-in -63.56, -52.6 86.58, -8.43 in-out-out SNCioo out-out ActLoopNT-out 9.1047 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -48.45 APE9-dihe-na -142.16, 106.07 APE8-dihe-in -57.79, 138.19 APE8-rot-out 182.41 APE67-dihe-in -58.85, -41.56 -95.36, -2.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.8627 APE9-dist-out 9.537 None None None XRAY 2.31 0.193 0.223 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8efj Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VMHA P47811 5 354 360.0 A1ACT:603 Type1 Inactive DFGin 10.8876 12.6554 None -91.57, 155.22 -78.87, -42.97 -134.13, 132.21 306.13, 106.97 -93.28, -173.32 in-in in 9.1199 Saltbr-in 2.4999 HRD-in -70.23, -50.72 73.72, -8.99 in-out-out SNCioo out-out ActLoopNT-out 21.4911 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 65.99 APE9-dihe-na -65.29, 141.53 APE8-dihe-out -65.65, -35.56 APE8-rot-in 296.74 APE67-dihe-in -54.93, -23.21 -63.02, -29.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7755 APE9-dist-out 11.8061 None None None XRAY 2.46 0.21 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmh Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.9836 13.1585 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.4266 Saltbr-in 2.5383 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.1108 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5031 APE9-dist-out 11.8253 None None None XRAY 2.4 0.207 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VT6A P47811 5 360 360.0 WHQ:503 Type1 Inactive DFGin 6.7293 15.1507 None -106.7, -137.28 -49.07, 131.85 -82.77, 153.72 284.07, 57.8 -72.41, 123.53 in-in in 9.1741 Saltbr-in 2.5587 HRD-in -64.24, -49.87 82.02, -7.33 in-out-out SNCioo out-out ActLoopNT-out 9.1157 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -58.08 APE9-dihe-na -131.51, 108.06 APE8-dihe-in -61.02, 149.49 APE8-rot-out 183.06 APE67-dihe-in -60.32, -29.4 -95.05, -11.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.7558 APE9-dist-out 9.4982 None None None XRAY 2.31 0.166 0.216 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vt6 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 8VWMA P47811 5 360 360.0 WHE:401 Type1 Inactive DFGin 6.7659 15.2325 None -105.37, -136.33 -48.31, 132.67 -83.1, 152.37 281.96, 61.27 -72.7, 123.36 in-in in 9.177 Saltbr-in 2.8721 HRD-in -65.49, -53.48 85.5, -8.91 in-out-out SNCioo out-out ActLoopNT-out 9.1811 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -44.6 APE9-dihe-na -141.61, 100.51 APE8-dihe-in -61.36, 142.62 APE8-rot-out 185.47 APE67-dihe-in -63.84, -26.29 -92.21, -4.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.0139 APE9-dist-out 9.637 None None None XRAY 1.94 0.177 0.222 A 367.0 348.0 8 25 17 8 [[24, 308]] 1.0 8vwm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2EWAA P47811 5 354 360.0 SB2:361 Type1 Inactive DFGin 6.575 15.1465 None -155.19, 179.59 -144.72, 110.73 -99.77, 145.73 66.01, 43.3 59.16, 999.0 in-in in 9.4738 Saltbr-in 2.6977 HRD-in -67.14, -51.92 76.56, -18.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -36.62 APE8-rot-in 319.01 APE67-dihe-in -54.41, -29.01 -77.11, -17.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.241 0.279 A 379.0 330.0 20 25 11 14 [[24, 308]] 1.0 2ewa Mus musculus CMGC_MAPK14_MOUSE CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YCUA P47811 6 359 360.0 SB4:401,OKZ:405 Type1,Allosteric Inactive DFGin 6.0979 14.3679 None -143.57, 175.48 60.18, 42.46 -110.51, 999.0 50.6, 83.02 999.0, 999.0 in-in in 9.1165 Saltbr-in 2.6532 HRD-in -71.9, -56.23 80.62, -14.35 in-out-out SNCioo out-out ActLoopNT-out 10.3489 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -118.54, 114.44 APE9-dihe-na -89.96, 150.08 APE8-dihe-in -65.08, 137.29 APE8-rot-in 294.76 APE67-dihe-in -63.71, -21.71 -110.97, 4.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7014 C162S None None XRAY 1.35 0.232 0.253 A 360.0 347.0 7 25 18 7 [[24, 308]] 1.0 6ycu Mus musculus CMGC_MAPK14_MOUSE CMGC 5.1e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5LARA P47811 4 353 360.0 6SH:401 Type2 Inactive DFGout 13.2905 10.4387 BBAminus -133.45, 176.6 -138.75, 105.58 -80.2, 0.76 291.45, 119.23 -103.68, -156.87 in-in in 9.0889 Saltbr-in 2.6691 HRD-in -69.38, -53.28 78.67, -10.79 in-out-out SNCioo out-out ActLoopNT-out 6.2083 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -150.44, 132.72 APE9-dihe-na -75.03, -47.05 APE8-dihe-in -134.28, 144.41 APE8-rot-out 176.96 APE67-dihe-in -65.62, -17.84 -109.49, 11.38 APE12-dist-in 11.0929 APE11-dist-in 8.925 APE10-dist-out 10.7829 APE9-dist-out 10.3035 None None None XRAY 1.5 0.171 0.205 A 361.0 350.0 0 25 25 0 [[24, 308]] 1.0 5lar Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4TA P47811 5 355 360.0 O8W:401 Type2 Inactive DFGout 13.3955 10.3789 BBAminus -144.71, -175.5 -142.03, 108.93 -81.5, -11.12 288.34, 120.37 77.48, -158.94 in-in in 9.3967 Saltbr-in 2.6808 HRD-in -65.74, -56.2 76.93, -24.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -102.36, 110.44 APE9-dihe-na -74.04, 131.72 APE8-dihe-out -46.21, -42.69 APE8-rot-in 287.63 APE67-dihe-in -64.67, -21.68 -58.48, -29.87 APE12-dist-none 999.0 APE11-dist-in 12.8491 APE10-dist-out 12.0006 APE9-dist-out 10.7269 None None None XRAY 1.98 0.201 0.251 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6y4t Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4UA P47811 5 355 360.0 O98:401 Type2 Inactive DFGout 13.5343 10.6091 BBAminus -141.86, -178.12 -140.97, 108.08 -77.71, -12.1 292.53, 118.95 71.89, -159.26 in-in in 9.2937 Saltbr-in 2.8004 HRD-in -69.64, -57.74 78.32, -9.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -81.39, 107.52 APE9-dihe-na -71.81, 133.12 APE8-dihe-out -54.21, -39.99 APE8-rot-in 289.32 APE67-dihe-in -64.78, -22.51 -60.96, -27.38 APE12-dist-none 999.0 APE11-dist-in 12.0152 APE10-dist-out 11.4107 APE9-dist-out 10.7477 None None None XRAY 1.86 0.192 0.241 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6y4u Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4VA P47811 5 355 360.0 O8Z:401 Type2 Inactive DFGout 13.4787 10.4527 BBAminus -139.41, -176.58 -143.81, 106.57 -80.04, -18.49 283.79, 123.68 78.51, -150.94 in-in in 9.437 Saltbr-in 2.9224 HRD-in -69.56, -58.59 79.18, -11.72 in-out-out SNCioo out-out ActLoopNT-out 20.851 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -103.51, 114.79 APE9-dihe-na -77.81, 122.67 APE8-dihe-out -48.41, -38.41 APE8-rot-in 303.02 APE67-dihe-in -59.86, -25.31 -52.21, -36.63 APE12-dist-none 999.0 APE11-dist-in 10.5606 APE10-dist-out 11.6414 APE9-dist-out 10.6746 None None None XRAY 1.75 0.191 0.222 A 361.0 343.0 8 25 17 8 [[24, 308]] 1.0 6y4v Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4WA P47811 5 355 360.0 O8T:401 Type2 Inactive DFGout 13.4391 10.5955 BBAminus -140.93, -175.05 -144.74, 105.28 -75.89, -17.02 288.84, 121.29 74.94, -159.64 in-out in 9.6447 Saltbr-out 4.6446 HRD-in -67.16, -56.28 75.39, -12.59 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -94.99, 104.56 APE9-dihe-na -79.86, 138.7 APE8-dihe-out -57.16, -42.08 APE8-rot-in 286.79 APE67-dihe-in -66.27, -23.7 -55.89, -29.45 APE12-dist-none 999.0 APE11-dist-in 11.6796 APE10-dist-out 11.2391 APE9-dist-out 10.8408 None None None XRAY 1.86 0.19 0.233 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6y4w Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y4XA P47811 1 360 360.0 O8Q:408 Type2 Inactive DFGout 13.696 10.823 BBAminus -149.62, 179.62 -142.72, 111.56 -75.36, -7.07 282.26, 124.72 75.09, -147.71 out-out out 10.3547 Saltbr-out 4.8762 HRD-in -71.54, -55.5 78.1, -16.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -111.91, 118.92 APE9-dihe-na -79.94, 124.56 APE8-dihe-out -51.51, -36.52 APE8-rot-in 307.99 APE67-dihe-in -62.34, -27.48 -49.26, -35.94 APE12-dist-none 999.0 APE11-dist-in 12.2084 APE10-dist-out 13.0262 APE9-dist-out 10.4219 None None None XRAY 1.6 0.17 0.204 A 361.0 351.0 9 25 16 9 [[24, 308]] 1.0 6y4x Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6Y6VA P47811 4 353 360.0 OE5:401 Type2 Inactive DFGout 13.6416 11.1096 BBAminus -145.73, -174.56 -146.2, 109.18 -72.0, -9.8 285.19, 125.4 53.02, 999.0 in-out in 9.8914 Saltbr-out 4.9219 HRD-in -59.95, -60.79 80.44, -15.1 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 120.85 APE8-dihe-out -54.18, -38.73 APE8-rot-in 283.8 APE67-dihe-in -61.52, -30.99 -63.8, -27.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8289 None None None XRAY 2.1 0.251 0.304 A 361.0 331.0 19 25 12 13 [[24, 308]] 1.0 6y6v Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YJCA P47811 4 352 360.0 OSZ:401 Type2 Inactive DFGout 13.4586 10.5464 BBAminus -139.92, -176.5 -139.91, 106.09 -88.23, 0.66 289.05, 130.6 -62.56, 999.0 in-in in 9.1742 Saltbr-in 2.7269 HRD-in -65.02, -54.9 81.2, -12.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 140.28 APE9-dihe-na -70.4, -54.9 APE8-dihe-in -130.7, 144.29 APE8-rot-out 184.39 APE67-dihe-in -65.14, -20.31 -104.69, 2.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5174 None None None XRAY 1.741 0.203 0.237 A 361.0 337.0 12 25 13 12 [[24, 308]] 1.0 6yjc Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6YK7A P47811 5 355 360.0 OU2:401 Type2 Inactive DFGout 13.2555 10.3644 BBAminus -133.06, 178.3 -142.12, 109.8 -80.39, -8.19 296.44, 118.38 65.61, -167.35 in-in in 9.2356 Saltbr-in 2.8771 HRD-in -73.77, -53.1 74.74, -13.49 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -83.66, 114.66 APE9-dihe-na -70.8, 127.89 APE8-dihe-out -51.01, -41.4 APE8-rot-in 286.15 APE67-dihe-in -63.42, -27.42 -60.43, -26.14 APE12-dist-none 999.0 APE11-dist-in 12.7948 APE10-dist-out 11.8108 APE9-dist-out 10.7927 None None None XRAY 1.9 0.186 0.235 A 361.0 341.0 10 25 15 10 [[24, 308]] 1.0 6yk7 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 6ZWRA P47811 5 353 360.0 OEB:401 Type2 Inactive DFGout 13.1552 10.4118 BBAminus -133.95, 179.2 -142.59, 106.98 -78.63, -9.38 290.08, 122.21 73.33, -138.6 in-in in 9.0868 Saltbr-in 2.7177 HRD-in -66.13, -57.41 77.62, -9.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 100.49 APE9-dihe-na -73.84, 130.35 APE8-dihe-out -50.53, -43.01 APE8-rot-in 294.93 APE67-dihe-in -63.61, -24.53 -40.59, -45.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.191 APE9-dist-out 10.6586 None None None XRAY 1.9 0.196 0.225 A 361.0 338.0 11 25 14 11 [[24, 308]] 1.0 6zwr Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BDQA P47811 5 353 360.0 TJZ:401 Type2 Inactive DFGout 13.0071 10.439 BBAminus -145.11, -176.65 -143.25, 106.89 -85.99, -12.64 286.55, 130.41 87.01, 999.0 in-none in 9.7176 Saltbr-none 999.0 HRD-in -62.24, -58.93 83.9, -21.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 113.01 APE8-dihe-out -46.72, -43.24 APE8-rot-out 179.73 APE67-dihe-in -53.55, -29.55 -45.05, -55.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8206 None None None XRAY 2.75 0.218 0.262 A 361.0 336.0 13 25 12 13 [[24, 308]] 1.0 7bdq Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BE4A P47811 4 352 360.0 TK5:401 Type2 Inactive DFGout 13.5254 10.6899 BBAminus -146.72, -171.32 -147.04, 99.47 -70.74, -21.85 288.34, 123.0 75.58, -140.33 in-out in 9.8945 Saltbr-out 4.6489 HRD-in -69.81, -56.07 78.08, -16.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 136.58 APE8-dihe-out -55.38, -36.52 APE8-rot-in 292.92 APE67-dihe-in -61.6, -24.47 -62.76, -30.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9196 None None None XRAY 2.1 0.217 0.268 A 361.0 331.0 18 25 13 12 [[24, 308]] 1.0 7be4 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BE5A P47811 4 352 360.0 TKB:403 Type2 Inactive DFGout 13.6504 10.8783 BBAminus -145.24, -177.93 -140.39, 104.25 -74.05, -22.12 289.39, 119.94 62.18, 999.0 in-in in 9.5284 Saltbr-in 3.0014 HRD-in -67.52, -58.26 81.02, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.64 APE8-dihe-out -48.96, -44.36 APE8-rot-in 280.11 APE67-dihe-in -63.22, -23.34 -38.31, -49.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9796 None None None XRAY 1.8 0.187 0.222 A 361.0 329.0 20 25 12 13 [[24, 308]] 1.0 7be5 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 2PUUA P47811 5 352 360.0 G2G:391 Type2 Inactive DFGout 14.475 10.7348 BBAminus -163.02, -178.87 -141.37, 110.1 -71.36, -4.93 286.25, 81.16 73.38, 999.0 in-out in 9.3245 Saltbr-out 4.7622 HRD-in -69.43, -54.67 75.33, -3.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 89.4 APE9-dihe-na -57.27, 116.93 APE8-dihe-out -54.47, -25.97 APE8-rot-out 129.27 APE67-dihe-in -41.71, -26.91 -50.81, -61.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6894 N14A None None XRAY 2.5 0.228 0.318 A 348.0 330.0 18 25 13 12 [[24, 308]] 1.0 2puu Mus musculus CMGC_MAPK14_MOUSE CMGC 3.8e-85 291.8 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P5KA P47811 5 352 360.0 P5K:362 Type3 Inactive DFGout 14.5249 9.3083 BBAminus -141.15, -168.68 -148.23, 99.3 -58.18, -32.6 276.48, 90.7 88.55, 999.0 in-in in 8.6057 Saltbr-in 2.7902 HRD-in -63.98, -57.19 74.55, -12.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 150.21 APE8-dihe-out -61.52, -32.15 APE8-rot-in 260.23 APE67-dihe-in -70.66, -25.54 -65.62, -20.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5465 None None None XRAY 2.09 0.214 0.265 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p5k Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P78A P47811 5 352 360.0 P78:362 Type3 Inactive DFGout 13.7085 9.6676 BBAminus -145.29, -172.71 -144.52, 103.86 -60.78, -27.28 283.97, 109.45 117.0, 999.0 in-in in 9.4899 Saltbr-in 2.8442 HRD-in -69.5, -62.61 90.57, -20.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.4 APE8-dihe-out -43.61, -34.17 APE8-rot-in 261.47 APE67-dihe-in -68.8, -24.58 -57.91, -21.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8066 None None None XRAY 2.3 0.247 0.313 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p78 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P79A P47811 5 352 360.0 P79:362 Type3 Inactive DFGout 14.0002 9.8729 BBAminus -151.22, -174.47 -141.93, 101.48 -66.27, -17.47 283.09, 111.48 104.1, 999.0 in-in in 9.2282 Saltbr-in 2.7858 HRD-in -63.58, -58.2 79.24, -16.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.77 APE8-dihe-out -56.29, -31.49 APE8-rot-in 268.32 APE67-dihe-in -72.21, -24.76 -62.87, -19.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5235 None None None XRAY 2.1 0.213 0.27 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p79 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P7AA P47811 5 352 360.0 P7A:362 Type3 Inactive DFGout 14.0192 8.9506 BBAminus -141.3, -162.35 -154.35, 95.38 -72.41, 28.1 269.3, 92.19 44.28, 999.0 in-in in 8.8264 Saltbr-in 3.1582 HRD-in -68.47, -56.82 86.62, -20.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.86 APE8-dihe-out -40.2, -40.94 APE8-rot-in 279.74 APE67-dihe-in -55.35, -23.72 -65.33, -37.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0411 None None None XRAY 2.31 0.23 0.298 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p7a Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P7BA P47811 5 352 360.0 P7B:362 Type3 Inactive DFGout 14.3218 9.1308 BBAminus -139.72, -169.55 -146.44, 103.45 -68.51, -32.05 266.87, 101.4 106.97, 999.0 in-in in 8.8363 Saltbr-in 2.9154 HRD-in -63.72, -60.5 81.04, -16.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.57 APE8-dihe-out -51.57, -34.06 APE8-rot-in 268.36 APE67-dihe-in -70.75, -19.21 -60.51, -28.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.4888 None None None XRAY 1.9 0.224 0.265 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p7b Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 3P7CA P47811 5 352 360.0 P7C:362 Type3 Inactive DFGout 14.1838 8.8862 BBAminus -148.94, 179.04 -136.31, 98.75 -67.28, -8.09 273.29, 107.9 73.35, 999.0 in-in in 8.6654 Saltbr-in 3.0018 HRD-in -66.58, -58.56 78.92, -19.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.98 APE8-dihe-out -68.5, -25.84 APE8-rot-out 232.65 APE67-dihe-in -58.76, -32.39 -62.96, -27.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8868 None None None XRAY 2.3 0.239 0.292 A 366.0 332.0 16 25 12 13 [[24, 308]] 1.0 3p7c Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 7BDOA P47811 5 353 360.0 TBK:401 Type2 Inactive DFGout 13.2743 10.6119 None -140.45, -176.17 -147.11, 100.95 -81.65, 173.27 306.65, 120.36 -120.47, 69.03 in-out in 9.678 Saltbr-out 5.5219 HRD-in -63.13, -55.95 75.66, -10.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.1 APE8-dihe-out -57.45, -51.16 APE8-rot-in 302.29 APE67-dihe-in -59.24, -31.49 -45.26, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8124 None None None XRAY 2.7 0.241 0.287 A 361.0 332.0 17 25 13 12 [[24, 308]] 1.0 7bdo Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
MAPK14 MK14_MOUSE 5NZZH P47811 5 352 360.0 AGS:60500 ATPlike None DFGin 6.5201 14.9123 BLAminus -107.76, 173.34 60.28, 95.29 -107.52, 29.84 280.25, 79.55 -61.87, -24.37 in-none in 9.249 Saltbr-none 999.0 HRD-in -88.17, -55.8 88.26, -17.82 none-in-in SNCnii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.4, 153.2 APE9-dihe-na 72.78, 157.17 APE8-dihe-in -63.99, 158.8 APE8-rot-in 301.47 APE67-dihe-in -70.1, -20.58 -71.77, -51.25 APE12-dist-in 12.0483 APE11-dist-in 11.371 APE10-dist-in 7.6507 APE9-dist-in 3.3502 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 H 360.0 337.0 9 25 25 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14