STE_MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Total number of chains: 38
Active chains: 2
Uniprot: M4K4_HUMAN
Kinase Domain Residues: 25 - 289
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 16 42.1% 4U43B
DFGin BLBplus 11 28.9% 4U40A
DFGin BLAminus 7 18.4% AF-O95819-K1A
DFGinter None 2 5.3% 4U3YA
DFGout BBAminus 1 2.6% 4U3YB
None None 1 2.6% 4U42B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O95819-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
AF-O95819-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
8V5IA 2.18 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo A1AAA Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4OBPA 2.27 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 2QU Type1 13 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U44A 2.43 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo 3D9 Type1 12 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U45A 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 3DC Type1 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4ZK5A 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 4P4 Type1 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U40A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U42A 2.504 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
4ZP5A 2.29 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4QG Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
5DI1A 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 5DF Type1 13 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
5J95A 2.5 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 6HH Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4RVTA 2.4 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo 3XM Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4OBOA 2.1 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 2QV Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4OBQA 2.19 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_iioo 2QT Type1 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U41A 2.2 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U43A 2.18 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo 3D8 Type1 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
5W5QA 2.33 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9X4 Type1.5_Back 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U3ZA 2.09 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
4U3YA 1.45 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U3YB 1.45 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 8 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U3ZB 2.09 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
4ZP5B 2.29 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
5DI1B 2.9 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
5J95B 2.5 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
8V5IB 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4RVTB 2.4 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4OBOB 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4OBPB 2.27 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4OBQB 2.19 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U40B 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U41B 2.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U43B 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U44B 2.43 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U45B 2.58 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4ZK5B 2.89 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
5W5QB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
4U42B 2.504 Inactive None‑None none-none none-out nonTYR APEdihe_aaioi APEdist_oooo 3C8 Type1 17 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4

STE_MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Total number of chains: 38
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 16 42.1% 4U43B
DFGin BLBplus 11 28.9% 4U40A
DFGin BLAminus 7 18.4% AF-O95819-K1A
DFGinter None 2 5.3% 4U3YA
DFGout BBAminus 1 2.6% 4U3YB
None None 1 2.6% 4U42B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M4K4_HUMAN AF-O95819-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN AF-O95819-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 297 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 8V5IA 2.18 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo A1AAA Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4OBPA 2.27 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 2QU Type1 13 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U44A 2.43 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo 3D9 Type1 12 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U45A 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 3DC Type1 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4ZK5A 2.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 4P4 Type1 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U40A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U42A 2.504 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4ZP5A 2.29 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4QG Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 5DI1A 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 5DF Type1 13 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 5J95A 2.5 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 6HH Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4RVTA 2.4 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo 3XM Type1 14 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4OBOA 2.1 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 2QV Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4OBQA 2.19 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_iioo 2QT Type1 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U41A 2.2 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 3C8 Type1 16 - 310 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U43A 2.18 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo 3D8 Type1 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 5W5QA 2.33 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 9X4 Type1.5_Back 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U3ZA 2.09 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U3YA 1.45 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U3YB 1.45 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 8 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U3ZB 2.09 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4ZP5B 2.29 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 5DI1B 2.9 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 5J95B 2.5 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 8V5IB 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4RVTB 2.4 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4OBOB 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4OBPB 2.27 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4OBQB 2.19 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U40B 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U41B 2.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U43B 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U44B 2.43 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U45B 2.58 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4ZK5B 2.89 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 5W5QB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
M4K4_HUMAN 4U42B 2.504 Inactive None‑None none-none none-out nonTYR APEdihe_aaioi APEdist_oooo 3C8 Type1 17 - 310 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens

STE_MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism