STE_MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Total number of chains: 38
Active chains: 2
Uniprot: M4K4_HUMAN
Kinase Domain Residues: 25 - 289
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 16 42.1% 4U43B
DFGin BLBplus 11 28.9% 4U40A
DFGin BLAminus 7 18.4% AF-O95819-K1A
DFGinter None 2 5.3% 4U3YA
DFGout BBAminus 1 2.6% 4U3YB
None None 1 2.6% 4U42B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP4K4 AF-O95819-K1A O95819 17 297 1239.0 No_ligand No_ligand Active DFGin 6.1926 13.9514 BLAminus -136.81, 174.09 66.37, 78.26 -90.27, 9.42 289.06, 87.24 -57.7, -34.75 in-in in 8.686 Saltbr-in 2.8755 HRD-in -74.51, -40.85 66.92, -1.7 in-in-in SNCiii in-in ActLoopNT-in 2.8433 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.59, 158.5 APE9-dihe-na 111.47, 178.23 APE8-dihe-in -86.87, 121.36 APE8-rot-in 306.79 APE67-dihe-in -69.96, -21.96 -44.19, -46.89 APE12-dist-in 8.44 APE11-dist-in 11.7118 APE10-dist-in 6.0192 APE9-dist-in 3.4431 None None None AF2 -1.0 1.0 1.0 A 281.0 281.0 0 28 28 0 [[25, 289]] 1.0 AF-O95819-K1 STE_MAP4K4_HUMAN STE 9.3e-103 348.9 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 AF-O95819-K3A O95819 17 297 1239.0 No_ligand No_ligand Active DFGin 6.3743 14.2452 BLAminus -141.71, 175.35 62.48, 73.36 -90.17, 6.99 287.2, 83.71 -54.94, -35.5 in-in in 9.0161 Saltbr-in 2.8064 HRD-in -75.67, -40.09 67.4, -11.01 in-in-in SNCiii in-in ActLoopNT-in 2.8454 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.19, 145.74 APE9-dihe-na 135.01, 178.04 APE8-dihe-in -83.87, 125.16 APE8-rot-in 300.8 APE67-dihe-in -73.22, -20.94 -42.67, -49.69 APE12-dist-in 9.2496 APE11-dist-in 11.8538 APE10-dist-in 6.1421 APE9-dist-in 3.4195 None None None AF2 -1.0 1.0 1.0 A 281.0 281.0 0 28 28 0 [[25, 289]] 1.0 AF-O95819-K3 STE_MAP4K4_HUMAN STE 9.3e-103 348.9 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 8V5IA O95819 14 309 1239.0 A1AAA:401 Type1 Inactive DFGin 6.6958 14.4044 BLAminus -123.5, 178.65 60.96, 93.48 -105.83, 16.81 281.58, 81.45 -85.41, 53.24 in-in in 8.8441 Saltbr-in 2.6928 HRD-in -57.52, -48.15 76.54, -0.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -74.03, 127.83 APE9-dihe-na -75.65, -135.31 APE8-dihe-in -86.64, 138.26 APE8-rot-out 184.11 APE67-dihe-in -46.08, -37.04 -88.46, -25.08 APE12-dist-in 12.2665 APE11-dist-in 11.4862 APE10-dist-out 11.2705 APE9-dist-out 9.3255 None None None XRAY 2.18 0.25 0.281 A 320.0 280.0 16 28 18 10 [[25, 289]] 1.0 8v5i STE_MAP4K4_HUMAN STE 1.5e-102 348.3 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4OBPA O95819 13 310 1239.0 2QU:403 Type1 Inactive DFGin 4.7836 13.6033 BLAminus -128.97, 169.5 73.58, 97.9 -102.12, 12.88 285.67, 94.77 -56.69, -42.4 in-in in 7.6876 Saltbr-in 2.7419 HRD-in -62.61, -50.95 78.28, -17.04 in-in-out SNCiio in-out ActLoopNT-in 3.0417 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -83.6, 129.84 APE9-dihe-na -78.54, -153.27 APE8-dihe-in -70.63, 136.27 APE8-rot-out 187.06 APE67-dihe-in -56.16, -28.41 -93.67, -10.95 APE12-dist-in 11.6203 APE11-dist-in 11.0033 APE10-dist-out 10.7337 APE9-dist-out 8.986 None None None XRAY 2.27 0.206 0.247 A 332.0 285.0 13 28 19 9 [[25, 289]] 1.0 4obp STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U44A O95819 12 310 1239.0 3D9:403 Type1 Inactive DFGin 5.0507 14.1311 BLAminus -125.36, 167.71 79.61, 93.06 -95.28, 22.54 291.23, 86.56 -55.69, -54.28 in-in in 8.0091 Saltbr-in 2.5641 HRD-in -62.33, -47.77 72.94, -6.66 in-out-out SNCioo out-out ActLoopNT-out 5.8518 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.34, 131.76 APE9-dihe-na -85.61, -160.71 APE8-dihe-in -63.18, 137.73 APE8-rot-out 184.51 APE67-dihe-in -60.62, -26.08 -92.68, -15.57 APE12-dist-in 11.4333 APE11-dist-in 10.3405 APE10-dist-out 10.6258 APE9-dist-out 8.9294 None None None XRAY 2.43 0.2 0.242 A 332.0 286.0 13 28 18 10 [[25, 289]] 1.0 4u44 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U45A O95819 12 311 1239.0 3DC:403 Type1 Inactive DFGin 5.0689 13.94 BLAminus -127.45, 173.33 65.43, 104.21 -102.41, 17.89 287.8, 99.11 -63.71, -25.04 in-in in 8.0463 Saltbr-in 2.8087 HRD-in -62.58, -46.98 71.79, -5.52 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.96, 128.65 APE9-dihe-na -77.97, -153.21 APE8-dihe-in -73.9, 135.02 APE8-rot-out 186.91 APE67-dihe-in -58.56, -30.15 -90.87, -14.08 APE12-dist-in 11.7172 APE11-dist-in 10.261 APE10-dist-out 10.6999 APE9-dist-out 8.8328 None None None XRAY 2.58 0.197 0.244 A 332.0 289.0 11 28 19 9 [[25, 289]] 1.0 4u45 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4ZK5A O95819 17 311 1239.0 4P4:403 Type1 Inactive DFGin 5.1083 13.4091 BLAminus -133.99, 163.85 75.06, 112.69 -118.18, 20.18 285.57, 95.54 -65.45, -27.24 in-in in 8.1724 Saltbr-in 2.906 HRD-in -71.58, -41.44 67.29, -5.12 in-in-out SNCiio in-out ActLoopNT-in 2.9218 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -74.43, -46.93 APE9-dihe-na 92.38, -177.43 APE8-dihe-in -66.4, 130.17 APE8-rot-out 193.11 APE67-dihe-in -52.43, -26.09 -92.37, -19.32 APE12-dist-in 11.5871 APE11-dist-in 10.5337 APE10-dist-out 11.2448 APE9-dist-out 9.2785 None None None XRAY 2.89 0.215 0.265 A 332.0 286.0 9 28 19 9 [[25, 289]] 1.0 4zk5 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U40A O95819 17 311 1239.0 ANP:401 ATPlike Inactive DFGin 3.8374 14.3902 BLBplus -136.79, 156.81 66.63, 45.06 -75.84, 145.72 56.03, 93.39 -61.09, 117.37 out-out out 11.6402 Saltbr-out 10.4893 HRD-in -68.35, -49.63 65.89, 2.04 out-out-out SNCooo out-out ActLoopNT-out 9.6283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, -36.45 APE9-dihe-na 89.46, 175.41 APE8-dihe-in -63.67, 133.35 APE8-rot-out 188.73 APE67-dihe-in -61.71, -22.93 -96.09, -7.57 APE12-dist-out 14.8768 APE11-dist-out 14.965 APE10-dist-out 15.9776 APE9-dist-out 9.4768 None None None XRAY 2.3 0.201 0.262 A 332.0 295.0 0 28 28 0 [[25, 289]] 1.0 4u40 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U42A O95819 16 310 1239.0 3C8:402 Type1 Inactive DFGin 4.215 13.3539 BLBplus -125.88, 165.63 67.48, 28.46 -78.89, 157.51 78.73, 85.53 61.14, 999.0 in-in in 8.3472 Saltbr-in 3.393 HRD-in -56.79, -64.0 92.25, -2.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -82.81, -36.94 APE9-dihe-na 72.75, -161.62 APE8-dihe-in -78.02, 131.54 APE8-rot-out 207.58 APE67-dihe-in -58.54, -23.37 -95.87, -12.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0807 T181E None None XRAY 2.504 0.231 0.303 A 332.0 282.0 13 28 15 13 [[25, 289]] 1.0 4u42 STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4ZP5A O95819 14 309 1239.0 4QG:400 Type1 Inactive DFGin 4.734 13.2817 BLBplus -132.61, 160.76 59.14, 61.57 -100.52, 160.93 59.94, 90.02 -124.84, 999.0 in-out in 9.3946 Saltbr-out 4.9444 HRD-in -65.39, -46.16 75.16, -11.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -94.86, 133.92 APE9-dihe-na -84.11, -148.47 APE8-dihe-in -72.99, 133.04 APE8-rot-out 188.07 APE67-dihe-in -48.97, -28.63 -87.45, -20.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.2129 None None None XRAY 2.29 0.231 0.264 A 309.0 284.0 12 28 16 12 [[25, 289]] 1.0 4zp5 STE_MAP4K4_HUMAN STE 1.3e-102 348.5 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 5DI1A O95819 13 309 1239.0 5DF:4000 Type1 Inactive DFGin 4.2602 13.3659 BLBplus -145.12, 159.02 72.53, 52.2 -89.55, 138.32 48.51, 95.38 -80.62, 999.0 in-out in 9.4027 Saltbr-out 3.985 HRD-in -61.2, -47.09 79.65, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.21, 124.07 APE9-dihe-na -81.57, -147.04 APE8-dihe-in -74.95, 131.45 APE8-rot-out 195.98 APE67-dihe-in -46.35, -33.38 -85.44, -21.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6024 None None None XRAY 2.9 0.2 0.249 A 310.0 285.0 12 28 16 12 [[25, 289]] 1.0 5di1 STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 5J95A O95819 14 309 1239.0 6HH:4000 Type1 Inactive DFGin 4.2418 13.5379 BLBplus -133.88, 158.51 61.23, 60.75 -96.39, 151.72 58.28, 90.54 -126.46, 999.0 in-in in 9.3928 Saltbr-in 3.0305 HRD-in -58.49, -50.73 79.94, -8.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -88.29, 128.45 APE9-dihe-na -81.99, -148.34 APE8-dihe-in -76.73, 130.72 APE8-rot-out 193.2 APE67-dihe-in -52.87, -25.48 -84.31, -21.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.0953 None None None XRAY 2.5 0.217 0.258 A 312.0 284.0 12 28 16 12 [[25, 289]] 1.0 5j95 STE_MAP4K4_HUMAN STE 1.4e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4RVTA O95819 14 309 1239.0 3XM:401 Type1 Inactive DFGin 4.5855 13.4884 BLBplus -120.36, 165.4 61.54, 67.44 -121.04, 175.63 60.64, 92.85 148.07, 137.03 in-in in 9.033 Saltbr-in 2.9913 HRD-in -61.37, -42.25 71.33, 2.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -84.66, 129.17 APE9-dihe-na -79.09, -153.2 APE8-dihe-in -77.5, 135.48 APE8-rot-out 183.7 APE67-dihe-in -66.91, -20.37 -89.59, -9.54 APE12-dist-out 15.8779 APE11-dist-out 16.2082 APE10-dist-out 15.2156 APE9-dist-out 8.925 None None None XRAY 2.4 0.212 0.278 A 328.0 281.0 15 28 17 11 [[25, 289]] 1.0 4rvt STE_MAP4K4_HUMAN STE 1.6e-102 348.2 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4OBOA O95819 16 310 1239.0 2QV:403 Type1 Inactive DFGin 4.8317 13.4495 BLBplus -140.76, 160.22 72.65, 57.21 -126.52, 139.47 80.19, 98.58 -105.22, 999.0 out-out out 11.6539 Saltbr-out 13.1245 HRD-in -69.62, -49.11 76.54, -12.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -107.35, 126.08 APE9-dihe-na -76.21, -153.35 APE8-dihe-in -73.39, 136.57 APE8-rot-out 191.35 APE67-dihe-in -55.68, -26.18 -93.03, -12.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4269 None None None XRAY 2.1 0.211 0.235 A 332.0 275.0 20 28 17 11 [[25, 289]] 1.0 4obo STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4OBQA O95819 16 311 1239.0 2QT:403 Type1 Inactive DFGin 4.041 13.1465 BLBplus -135.08, 157.4 64.12, 69.09 -116.53, 151.79 64.01, 94.51 149.44, -65.61 out-out out 10.5976 Saltbr-out 5.7413 HRD-in -68.06, -46.13 74.24, -12.59 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.88, 123.06 APE9-dihe-na -75.78, -148.16 APE8-dihe-in -76.95, 135.8 APE8-rot-out 192.58 APE67-dihe-in -60.09, -22.9 -91.57, -13.0 APE12-dist-in 12.6744 APE11-dist-in 11.7974 APE10-dist-out 12.3835 APE9-dist-out 9.1625 None None None XRAY 2.19 0.207 0.24 A 332.0 275.0 21 28 17 11 [[25, 289]] 1.0 4obq STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U41A O95819 16 310 1239.0 3C8:401 Type1 Inactive DFGin 4.5559 13.4666 BLBplus -138.61, 161.87 78.15, 25.36 -79.82, 151.09 70.06, 91.23 45.12, 999.0 out-out out 11.8383 Saltbr-out 12.0522 HRD-in -72.49, -61.04 87.54, -14.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -106.68, 129.18 APE9-dihe-na -77.17, -152.77 APE8-dihe-in -73.3, 139.87 APE8-rot-out 192.53 APE67-dihe-in -66.12, -22.6 -99.31, -3.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4526 None None None XRAY 2.2 0.203 0.259 A 332.0 275.0 20 28 17 11 [[25, 289]] 1.0 4u41 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U43A O95819 14 311 1239.0 3D8:401 Type1 Inactive DFGin 4.1532 13.2791 BLBplus -128.02, 167.59 53.52, 51.18 -89.85, 159.42 63.11, 99.17 62.64, 20.89 in-in in 9.4481 Saltbr-in 3.1166 HRD-in -63.88, -52.19 81.86, -10.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.17, 129.4 APE9-dihe-na -73.75, -152.4 APE8-dihe-in -76.21, 141.15 APE8-rot-out 189.14 APE67-dihe-in -55.54, -27.45 -95.27, -11.48 APE12-dist-in 13.1305 APE11-dist-in 12.0937 APE10-dist-out 12.5275 APE9-dist-out 8.5145 None None None XRAY 2.18 0.199 0.242 A 332.0 287.0 11 28 17 11 [[25, 289]] 1.0 4u43 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 5W5QA O95819 17 311 1239.0 9X4:401 Type1.5_Back Inactive DFGin 3.9393 13.418 BLBplus -132.02, 157.98 62.56, 44.92 -73.53, 143.63 61.83, 88.23 -61.33, 130.13 out-out out 11.1194 Saltbr-out 7.593 HRD-in -63.45, -47.09 75.06, -12.67 out-out-out SNCooo out-out ActLoopNT-out 10.2142 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -103.97, 125.84 APE9-dihe-na -77.42, -147.12 APE8-dihe-in -76.77, 136.92 APE8-rot-out 181.65 APE67-dihe-in -57.08, -24.3 -88.98, -16.47 APE12-dist-out 15.0412 APE11-dist-out 14.8528 APE10-dist-out 16.0807 APE9-dist-out 8.8907 None None None XRAY 2.33 0.211 0.235 A 332.0 291.0 4 28 28 0 [[25, 289]] 1.0 5w5q STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U3ZA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.504 10.1084 None -90.3, 128.59 75.45, 163.28 -151.97, 31.14 43.16, 85.73 119.13, -6.79 out-out out 13.9945 Saltbr-out 13.772 HRD-in -72.3, -49.26 78.71, -16.24 out-out-out SNCooo out-out ActLoopNT-out 5.3051 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.57, 126.67 APE9-dihe-na -83.8, -149.21 APE8-dihe-in -69.81, 136.64 APE8-rot-out 191.8 APE67-dihe-in -65.68, -25.19 -91.82, -5.09 APE12-dist-out 18.0443 APE11-dist-out 17.2286 APE10-dist-out 18.4608 APE9-dist-out 9.95 T181E None None XRAY 2.09 0.186 0.249 A 332.0 282.0 13 28 28 0 [[25, 289]] 1.0 4u3z STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U3YA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.685 10.2954 None -88.99, 126.24 79.22, 151.13 -137.58, 35.87 48.82, 95.81 105.67, -5.01 out-out out 13.9033 Saltbr-out 14.4409 HRD-in -83.26, -53.16 70.55, 5.66 out-out-out SNCooo out-out ActLoopNT-out 5.7661 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.98, -47.61 APE9-dihe-na 95.3, -170.42 APE8-dihe-in -81.29, 138.53 APE8-rot-out 188.11 APE67-dihe-in -65.33, -22.86 -89.45, -12.96 APE12-dist-out 15.7712 APE11-dist-out 17.3079 APE10-dist-out 19.3169 APE9-dist-out 9.8362 None None None XRAY 1.45 0.184 0.207 A 332.0 295.0 0 28 28 0 [[25, 289]] 1.0 4u3y STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U3YB O95819 8 311 1239.0 No_ligand No_ligand Inactive DFGout 15.9836 4.7861 BBAminus -66.82, 136.69 -142.99, 93.73 -97.25, 33.21 286.77, 104.13 94.14, 55.99 out-out out 14.2412 Saltbr-out 11.968 HRD-in -69.2, -51.17 81.23, -14.38 out-out-out SNCooo out-out ActLoopNT-out 6.7383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -101.1, 129.97 APE9-dihe-na -81.01, -148.67 APE8-dihe-in -77.36, 139.73 APE8-rot-out 188.85 APE67-dihe-in -65.74, -23.58 -89.39, -13.52 APE12-dist-out 18.5642 APE11-dist-out 16.6679 APE10-dist-out 17.4754 APE9-dist-out 9.2719 None None None XRAY 1.45 0.184 0.207 B 332.0 300.0 4 28 28 0 [[25, 289]] 1.0 4u3y STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U3ZB O95819 14 311 1239.0 No_ligand No_ligand Inactive DFGout 16.3637 5.0186 None -61.71, 132.97 -142.2, 95.96 -99.94, 27.85 284.41, 110.75 76.81, -87.36 out-out out 14.2449 Saltbr-out 12.9437 HRD-in -72.98, -48.48 82.25, -12.79 out-out-out SNCooo out-out ActLoopNT-out 7.9083 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.13, -41.18 APE9-dihe-na 98.64, -167.9 APE8-dihe-in -91.19, 134.56 APE8-rot-out 184.77 APE67-dihe-in -58.28, -32.99 -88.54, -13.57 APE12-dist-out 14.9067 APE11-dist-out 15.2609 APE10-dist-out 17.5937 APE9-dist-out 9.505 T181E None None XRAY 2.09 0.186 0.249 B 332.0 294.0 4 28 28 0 [[25, 289]] 1.0 4u3z STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4ZP5B O95819 10 309 1239.0 No_ligand No_ligand Inactive DFGout 16.4542 4.6876 None -64.64, 129.59 -138.51, 97.13 -106.95, 31.03 281.11, 111.35 97.44, 45.94 out-out out 14.5537 Saltbr-out 12.4413 HRD-in -65.77, -45.75 75.05, -12.45 out-out-out SNCooo out-out ActLoopNT-out 6.7588 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -58.03, -41.7 APE9-dihe-na 93.24, -171.79 APE8-dihe-in -74.39, 128.12 APE8-rot-out 190.93 APE67-dihe-in -47.46, -31.21 -87.26, -21.24 APE12-dist-out 18.9287 APE11-dist-out 17.7664 APE10-dist-out 18.651 APE9-dist-out 9.8972 None None None XRAY 2.29 0.231 0.264 B 309.0 300.0 0 28 28 0 [[25, 289]] 1.0 4zp5 STE_MAP4K4_HUMAN STE 1.3e-102 348.5 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 5DI1B O95819 10 309 1239.0 No_ligand No_ligand Inactive DFGout 16.65 4.6926 None -66.94, 114.31 -129.18, 93.61 -101.31, 19.38 277.91, 108.92 116.45, 30.54 out-out out 14.1997 Saltbr-out 11.6069 HRD-in -63.56, -41.77 76.67, -20.55 out-out-out SNCooo out-out ActLoopNT-out 6.5825 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -51.73, -39.66 APE9-dihe-na 89.13, -169.86 APE8-dihe-in -77.09, 130.53 APE8-rot-out 194.93 APE67-dihe-in -46.23, -34.99 -85.22, -21.26 APE12-dist-out 18.5161 APE11-dist-out 17.4174 APE10-dist-out 18.3703 APE9-dist-out 9.9644 None None None XRAY 2.9 0.2 0.249 B 310.0 300.0 0 28 28 0 [[25, 289]] 1.0 5di1 STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 5J95B O95819 10 309 1239.0 No_ligand No_ligand Inactive DFGout 16.7456 4.9523 None -64.71, 127.31 -142.47, 97.41 -109.0, 39.3 286.18, 99.3 87.98, 51.73 out-out out 14.5993 Saltbr-out 12.6468 HRD-in -63.81, -43.11 75.14, -8.54 out-out-out SNCooo out-out ActLoopNT-out 6.8052 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.17, -35.56 APE9-dihe-na 95.5, -178.39 APE8-dihe-in -77.01, 128.44 APE8-rot-out 195.18 APE67-dihe-in -52.87, -26.45 -82.63, -22.03 APE12-dist-out 18.7511 APE11-dist-out 17.3427 APE10-dist-out 18.3542 APE9-dist-out 9.5572 None None None XRAY 2.5 0.217 0.258 B 312.0 300.0 0 28 28 0 [[25, 289]] 1.0 5j95 STE_MAP4K4_HUMAN STE 1.4e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 8V5IB O95819 16 311 1239.0 No_ligand No_ligand Inactive DFGout 16.3982 4.7739 None -64.57, 130.96 -143.69, 108.6 -121.09, 48.4 292.52, 92.46 85.4, 50.21 out-out out 14.7644 Saltbr-out 12.4066 HRD-in -69.53, -50.19 82.74, -16.12 out-out-out SNCooo out-out ActLoopNT-out 6.9023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.54, -33.43 APE9-dihe-na 91.78, -165.44 APE8-dihe-in -88.83, 131.09 APE8-rot-out 196.95 APE67-dihe-in -58.07, -26.81 -94.4, -14.8 APE12-dist-out 18.5475 APE11-dist-out 17.2708 APE10-dist-out 18.5983 APE9-dist-out 9.9307 None None None XRAY 2.18 0.25 0.281 B 320.0 288.0 8 28 28 0 [[25, 289]] 1.0 8v5i STE_MAP4K4_HUMAN STE 1.5e-102 348.3 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4RVTB O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.6846 4.9727 None -62.7, 125.27 -136.33, 95.26 -98.1, 34.78 287.72, 112.93 97.52, 46.97 out-out out 15.2742 Saltbr-out 12.6039 HRD-in -66.59, -46.53 87.67, -15.84 out-out-out SNCooo out-out ActLoopNT-out 6.8824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.99, -29.45 APE9-dihe-na 84.04, -167.43 APE8-dihe-in -96.0, 129.43 APE8-rot-out 180.8 APE67-dihe-in -64.61, -28.12 -84.38, -17.27 APE12-dist-out 19.1017 APE11-dist-out 17.6296 APE10-dist-out 18.9428 APE9-dist-out 10.1714 None None None XRAY 2.4 0.212 0.278 B 328.0 297.0 2 28 28 0 [[25, 289]] 1.0 4rvt STE_MAP4K4_HUMAN STE 1.6e-102 348.2 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4OBOB O95819 12 311 1239.0 No_ligand No_ligand Inactive DFGout 16.9129 4.6873 None -63.05, 130.05 -138.12, 97.92 -103.44, 31.91 283.52, 109.33 99.58, 56.89 out-out out 14.9404 Saltbr-out 13.3132 HRD-in -70.5, -47.99 76.13, -10.82 out-out-out SNCooo out-out ActLoopNT-out 6.7149 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.79, -38.18 APE9-dihe-na 92.33, -174.5 APE8-dihe-in -75.99, 132.78 APE8-rot-out 188.97 APE67-dihe-in -56.48, -27.21 -92.95, -11.65 APE12-dist-out 19.0154 APE11-dist-out 17.7139 APE10-dist-out 18.8623 APE9-dist-out 9.8873 None None None XRAY 2.1 0.211 0.235 B 332.0 297.0 3 28 28 0 [[25, 289]] 1.0 4obo STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4OBPB O95819 14 311 1239.0 No_ligand No_ligand Inactive DFGout 16.5534 4.9619 None -62.72, 128.65 -142.36, 99.68 -104.53, 30.43 285.25, 110.07 95.14, 56.71 out-out out 14.884 Saltbr-out 12.5472 HRD-in -64.48, -47.47 81.22, -20.24 out-out-out SNCooo out-out ActLoopNT-out 6.8943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.68, -34.65 APE9-dihe-na 85.15, -175.89 APE8-dihe-in -71.57, 131.05 APE8-rot-out 189.9 APE67-dihe-in -55.92, -31.18 -92.36, -12.02 APE12-dist-out 18.6917 APE11-dist-out 17.3709 APE10-dist-out 18.5839 APE9-dist-out 9.9472 None None None XRAY 2.27 0.206 0.247 B 332.0 290.0 8 28 28 0 [[25, 289]] 1.0 4obp STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4OBQB O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.7824 4.8378 None -65.54, 130.15 -138.36, 99.21 -108.3, 38.9 279.54, 113.84 89.61, 54.09 out-out out 14.4731 Saltbr-out 11.92 HRD-in -68.67, -45.56 74.55, -13.2 out-out-out SNCooo out-out ActLoopNT-out 6.7539 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.47, -36.9 APE9-dihe-na 88.64, -174.79 APE8-dihe-in -73.62, 132.18 APE8-rot-out 194.87 APE67-dihe-in -62.14, -25.0 -92.39, -12.75 APE12-dist-out 18.972 APE11-dist-out 17.016 APE10-dist-out 18.4004 APE9-dist-out 9.8147 None None None XRAY 2.19 0.207 0.24 B 332.0 293.0 6 28 28 0 [[25, 289]] 1.0 4obq STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U40B O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.9789 4.8603 None -58.33, 130.0 -140.04, 88.12 -92.84, 32.55 283.77, 110.6 100.78, 53.01 out-out out 15.1334 Saltbr-out 13.5311 HRD-in -74.7, -46.16 79.18, -17.97 out-out-out SNCooo out-out ActLoopNT-out 6.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.09, 129.36 APE9-dihe-na -87.21, -140.1 APE8-dihe-in -85.81, 130.5 APE8-rot-out 186.42 APE67-dihe-in -60.07, -29.15 -83.3, -16.35 APE12-dist-out 19.1266 APE11-dist-out 16.5875 APE10-dist-out 18.0955 APE9-dist-out 9.9159 None None None XRAY 2.3 0.201 0.262 B 332.0 299.0 0 28 28 0 [[25, 289]] 1.0 4u40 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U41B O95819 12 311 1239.0 No_ligand No_ligand Inactive DFGout 17.0636 5.0508 None -62.78, 130.42 -138.16, 96.26 -100.9, 39.01 294.93, 102.33 95.24, 62.11 out-out out 15.2882 Saltbr-out 13.1041 HRD-in -72.84, -48.94 82.78, -12.29 out-out-out SNCooo out-out ActLoopNT-out 6.8998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.17, -41.78 APE9-dihe-na 94.81, -169.92 APE8-dihe-in -89.48, 133.13 APE8-rot-out 186.04 APE67-dihe-in -63.4, -21.94 -91.46, -13.31 APE12-dist-out 18.8619 APE11-dist-out 17.5536 APE10-dist-out 18.7 APE9-dist-out 10.034 None None None XRAY 2.2 0.203 0.259 B 332.0 297.0 3 28 28 0 [[25, 289]] 1.0 4u41 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U43B O95819 10 311 1239.0 No_ligand No_ligand Inactive DFGout 16.2889 4.728 None -57.91, 126.01 -134.35, 92.48 -104.97, 41.66 281.52, 110.23 90.51, 59.66 out-out out 14.4356 Saltbr-out 13.0401 HRD-in -63.71, -51.88 82.9, -12.63 out-out-out SNCooo out-out ActLoopNT-out 6.9686 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.89, 129.63 APE9-dihe-na -74.53, -145.51 APE8-dihe-in -78.73, 137.83 APE8-rot-out 191.54 APE67-dihe-in -55.37, -28.59 -94.36, -10.33 APE12-dist-out 18.4658 APE11-dist-out 16.8971 APE10-dist-out 17.7292 APE9-dist-out 8.905 None None None XRAY 2.18 0.199 0.242 B 332.0 302.0 0 28 28 0 [[25, 289]] 1.0 4u43 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U44B O95819 14 311 1239.0 No_ligand No_ligand Inactive DFGout 17.3235 5.1579 None -66.19, 124.42 -129.8, 104.4 -108.16, 36.59 285.84, 114.28 95.97, 52.2 out-out out 15.1897 Saltbr-out 12.4272 HRD-in -74.8, -44.18 78.85, -14.34 out-out-out SNCooo out-out ActLoopNT-out 6.9068 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.22, -32.76 APE9-dihe-na 87.31, -162.41 APE8-dihe-in -88.16, 129.9 APE8-rot-out 203.29 APE67-dihe-in -66.88, -24.12 -90.95, -10.05 APE12-dist-out 18.7803 APE11-dist-out 17.1659 APE10-dist-out 18.4854 APE9-dist-out 10.0716 None None None XRAY 2.43 0.2 0.242 B 332.0 296.0 2 28 28 0 [[25, 289]] 1.0 4u44 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U45B O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.9584 4.9964 None -61.09, 130.9 -144.2, 101.4 -110.75, 46.12 286.45, 112.17 82.14, 51.37 out-out out 14.8572 Saltbr-out 12.1718 HRD-in -63.13, -45.9 75.3, -9.54 out-out-out SNCooo out-out ActLoopNT-out 6.8706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.5, -35.78 APE9-dihe-na 88.02, -170.58 APE8-dihe-in -75.79, 130.77 APE8-rot-out 191.37 APE67-dihe-in -60.13, -31.31 -89.68, -14.05 APE12-dist-out 18.7716 APE11-dist-out 17.608 APE10-dist-out 18.6925 APE9-dist-out 9.8227 None None None XRAY 2.58 0.197 0.244 B 332.0 295.0 4 28 28 0 [[25, 289]] 1.0 4u45 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4ZK5B O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.4947 5.1046 None -63.13, 129.25 -143.2, 101.72 -113.19, 44.1 293.79, 101.12 81.03, 58.31 out-out out 14.8357 Saltbr-out 12.562 HRD-in -67.58, -44.45 74.1, -16.4 out-out-out SNCooo out-out ActLoopNT-out 6.7885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -93.65, 113.34 APE9-dihe-na -72.51, -150.61 APE8-dihe-in -67.92, 128.89 APE8-rot-out 193.82 APE67-dihe-in -53.25, -26.28 -91.33, -20.14 APE12-dist-out 18.8718 APE11-dist-out 17.6074 APE10-dist-out 18.2462 APE9-dist-out 9.9036 None None None XRAY 2.89 0.215 0.265 B 332.0 294.0 5 28 28 0 [[25, 289]] 1.0 4zk5 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 5W5QB O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.8719 5.2035 None -58.35, 131.39 -144.13, 97.43 -101.7, 28.86 285.52, 109.11 101.25, 47.95 out-out out 14.6483 Saltbr-out 12.422 HRD-in -68.93, -44.79 75.98, -15.73 out-out-out SNCooo out-out ActLoopNT-out 6.9666 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.14, -40.78 APE9-dihe-na 92.62, -172.13 APE8-dihe-in -78.44, 133.98 APE8-rot-out 181.47 APE67-dihe-in -57.39, -27.0 -90.37, -15.82 APE12-dist-out 18.7283 APE11-dist-out 17.1888 APE10-dist-out 18.3263 APE9-dist-out 9.8178 None None None XRAY 2.33 0.211 0.235 B 332.0 297.0 2 28 28 0 [[25, 289]] 1.0 5w5q STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 4U42B O95819 17 310 1239.0 3C8:401 Type1 Inactive None 999.0 12.9041 None -137.73, 160.05 71.57, 38.3 -85.6, 128.16 56.27, 77.37 25.63, 81.69 none-none none 999.0 Saltbr-none 999.0 HRD-in -52.68, -50.82 83.11, -7.01 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.72, 121.45 APE9-dihe-na -84.48, -134.35 APE8-dihe-in -96.15, 130.99 APE8-rot-out 195.27 APE67-dihe-in -59.31, -29.62 -83.53, -22.99 APE12-dist-out 15.3781 APE11-dist-out 14.8056 APE10-dist-out 16.484 APE9-dist-out 9.7003 T181E None None XRAY 2.504 0.231 0.303 B 332.0 265.0 29 28 17 11 [[25, 289]] 1.0 4u42 STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4

STE_MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Total number of chains: 38
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 16 42.1% 4U43B
DFGin BLBplus 11 28.9% 4U40A
DFGin BLAminus 7 18.4% AF-O95819-K1A
DFGinter None 2 5.3% 4U3YA
DFGout BBAminus 1 2.6% 4U3YB
None None 1 2.6% 4U42B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP4K4 M4K4_HUMAN AF-O95819-K1A O95819 17 297 1239.0 No_ligand No_ligand Active DFGin 6.1926 13.9514 BLAminus -136.81, 174.09 66.37, 78.26 -90.27, 9.42 289.06, 87.24 -57.7, -34.75 in-in in 8.686 Saltbr-in 2.8755 HRD-in -74.51, -40.85 66.92, -1.7 in-in-in SNCiii in-in ActLoopNT-in 2.8433 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.59, 158.5 APE9-dihe-na 111.47, 178.23 APE8-dihe-in -86.87, 121.36 APE8-rot-in 306.79 APE67-dihe-in -69.96, -21.96 -44.19, -46.89 APE12-dist-in 8.44 APE11-dist-in 11.7118 APE10-dist-in 6.0192 APE9-dist-in 3.4431 None None None AF2 -1.0 1.0 1.0 A 281.0 281.0 0 28 28 0 [[25, 289]] 1.0 AF-O95819-K1 Homo sapiens STE_MAP4K4_HUMAN STE 9.3e-103 348.9 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN AF-O95819-K3A O95819 17 297 1239.0 No_ligand No_ligand Active DFGin 6.3743 14.2452 BLAminus -141.71, 175.35 62.48, 73.36 -90.17, 6.99 287.2, 83.71 -54.94, -35.5 in-in in 9.0161 Saltbr-in 2.8064 HRD-in -75.67, -40.09 67.4, -11.01 in-in-in SNCiii in-in ActLoopNT-in 2.8454 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.19, 145.74 APE9-dihe-na 135.01, 178.04 APE8-dihe-in -83.87, 125.16 APE8-rot-in 300.8 APE67-dihe-in -73.22, -20.94 -42.67, -49.69 APE12-dist-in 9.2496 APE11-dist-in 11.8538 APE10-dist-in 6.1421 APE9-dist-in 3.4195 None None None AF2 -1.0 1.0 1.0 A 281.0 281.0 0 28 28 0 [[25, 289]] 1.0 AF-O95819-K3 Homo sapiens STE_MAP4K4_HUMAN STE 9.3e-103 348.9 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 8V5IA O95819 14 309 1239.0 A1AAA:401 Type1 Inactive DFGin 6.6958 14.4044 BLAminus -123.5, 178.65 60.96, 93.48 -105.83, 16.81 281.58, 81.45 -85.41, 53.24 in-in in 8.8441 Saltbr-in 2.6928 HRD-in -57.52, -48.15 76.54, -0.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -74.03, 127.83 APE9-dihe-na -75.65, -135.31 APE8-dihe-in -86.64, 138.26 APE8-rot-out 184.11 APE67-dihe-in -46.08, -37.04 -88.46, -25.08 APE12-dist-in 12.2665 APE11-dist-in 11.4862 APE10-dist-out 11.2705 APE9-dist-out 9.3255 None None None XRAY 2.18 0.25 0.281 A 320.0 280.0 16 28 18 10 [[25, 289]] 1.0 8v5i Homo sapiens STE_MAP4K4_HUMAN STE 1.5e-102 348.3 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4OBPA O95819 13 310 1239.0 2QU:403 Type1 Inactive DFGin 4.7836 13.6033 BLAminus -128.97, 169.5 73.58, 97.9 -102.12, 12.88 285.67, 94.77 -56.69, -42.4 in-in in 7.6876 Saltbr-in 2.7419 HRD-in -62.61, -50.95 78.28, -17.04 in-in-out SNCiio in-out ActLoopNT-in 3.0417 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -83.6, 129.84 APE9-dihe-na -78.54, -153.27 APE8-dihe-in -70.63, 136.27 APE8-rot-out 187.06 APE67-dihe-in -56.16, -28.41 -93.67, -10.95 APE12-dist-in 11.6203 APE11-dist-in 11.0033 APE10-dist-out 10.7337 APE9-dist-out 8.986 None None None XRAY 2.27 0.206 0.247 A 332.0 285.0 13 28 19 9 [[25, 289]] 1.0 4obp Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U44A O95819 12 310 1239.0 3D9:403 Type1 Inactive DFGin 5.0507 14.1311 BLAminus -125.36, 167.71 79.61, 93.06 -95.28, 22.54 291.23, 86.56 -55.69, -54.28 in-in in 8.0091 Saltbr-in 2.5641 HRD-in -62.33, -47.77 72.94, -6.66 in-out-out SNCioo out-out ActLoopNT-out 5.8518 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.34, 131.76 APE9-dihe-na -85.61, -160.71 APE8-dihe-in -63.18, 137.73 APE8-rot-out 184.51 APE67-dihe-in -60.62, -26.08 -92.68, -15.57 APE12-dist-in 11.4333 APE11-dist-in 10.3405 APE10-dist-out 10.6258 APE9-dist-out 8.9294 None None None XRAY 2.43 0.2 0.242 A 332.0 286.0 13 28 18 10 [[25, 289]] 1.0 4u44 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U45A O95819 12 311 1239.0 3DC:403 Type1 Inactive DFGin 5.0689 13.94 BLAminus -127.45, 173.33 65.43, 104.21 -102.41, 17.89 287.8, 99.11 -63.71, -25.04 in-in in 8.0463 Saltbr-in 2.8087 HRD-in -62.58, -46.98 71.79, -5.52 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.96, 128.65 APE9-dihe-na -77.97, -153.21 APE8-dihe-in -73.9, 135.02 APE8-rot-out 186.91 APE67-dihe-in -58.56, -30.15 -90.87, -14.08 APE12-dist-in 11.7172 APE11-dist-in 10.261 APE10-dist-out 10.6999 APE9-dist-out 8.8328 None None None XRAY 2.58 0.197 0.244 A 332.0 289.0 11 28 19 9 [[25, 289]] 1.0 4u45 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4ZK5A O95819 17 311 1239.0 4P4:403 Type1 Inactive DFGin 5.1083 13.4091 BLAminus -133.99, 163.85 75.06, 112.69 -118.18, 20.18 285.57, 95.54 -65.45, -27.24 in-in in 8.1724 Saltbr-in 2.906 HRD-in -71.58, -41.44 67.29, -5.12 in-in-out SNCiio in-out ActLoopNT-in 2.9218 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -74.43, -46.93 APE9-dihe-na 92.38, -177.43 APE8-dihe-in -66.4, 130.17 APE8-rot-out 193.11 APE67-dihe-in -52.43, -26.09 -92.37, -19.32 APE12-dist-in 11.5871 APE11-dist-in 10.5337 APE10-dist-out 11.2448 APE9-dist-out 9.2785 None None None XRAY 2.89 0.215 0.265 A 332.0 286.0 9 28 19 9 [[25, 289]] 1.0 4zk5 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U40A O95819 17 311 1239.0 ANP:401 ATPlike Inactive DFGin 3.8374 14.3902 BLBplus -136.79, 156.81 66.63, 45.06 -75.84, 145.72 56.03, 93.39 -61.09, 117.37 out-out out 11.6402 Saltbr-out 10.4893 HRD-in -68.35, -49.63 65.89, 2.04 out-out-out SNCooo out-out ActLoopNT-out 9.6283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, -36.45 APE9-dihe-na 89.46, 175.41 APE8-dihe-in -63.67, 133.35 APE8-rot-out 188.73 APE67-dihe-in -61.71, -22.93 -96.09, -7.57 APE12-dist-out 14.8768 APE11-dist-out 14.965 APE10-dist-out 15.9776 APE9-dist-out 9.4768 None None None XRAY 2.3 0.201 0.262 A 332.0 295.0 0 28 28 0 [[25, 289]] 1.0 4u40 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U42A O95819 16 310 1239.0 3C8:402 Type1 Inactive DFGin 4.215 13.3539 BLBplus -125.88, 165.63 67.48, 28.46 -78.89, 157.51 78.73, 85.53 61.14, 999.0 in-in in 8.3472 Saltbr-in 3.393 HRD-in -56.79, -64.0 92.25, -2.77 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -82.81, -36.94 APE9-dihe-na 72.75, -161.62 APE8-dihe-in -78.02, 131.54 APE8-rot-out 207.58 APE67-dihe-in -58.54, -23.37 -95.87, -12.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0807 T181E None None XRAY 2.504 0.231 0.303 A 332.0 282.0 13 28 15 13 [[25, 289]] 1.0 4u42 Homo sapiens STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4ZP5A O95819 14 309 1239.0 4QG:400 Type1 Inactive DFGin 4.734 13.2817 BLBplus -132.61, 160.76 59.14, 61.57 -100.52, 160.93 59.94, 90.02 -124.84, 999.0 in-out in 9.3946 Saltbr-out 4.9444 HRD-in -65.39, -46.16 75.16, -11.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -94.86, 133.92 APE9-dihe-na -84.11, -148.47 APE8-dihe-in -72.99, 133.04 APE8-rot-out 188.07 APE67-dihe-in -48.97, -28.63 -87.45, -20.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.2129 None None None XRAY 2.29 0.231 0.264 A 309.0 284.0 12 28 16 12 [[25, 289]] 1.0 4zp5 Homo sapiens STE_MAP4K4_HUMAN STE 1.3e-102 348.5 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 5DI1A O95819 13 309 1239.0 5DF:4000 Type1 Inactive DFGin 4.2602 13.3659 BLBplus -145.12, 159.02 72.53, 52.2 -89.55, 138.32 48.51, 95.38 -80.62, 999.0 in-out in 9.4027 Saltbr-out 3.985 HRD-in -61.2, -47.09 79.65, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.21, 124.07 APE9-dihe-na -81.57, -147.04 APE8-dihe-in -74.95, 131.45 APE8-rot-out 195.98 APE67-dihe-in -46.35, -33.38 -85.44, -21.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6024 None None None XRAY 2.9 0.2 0.249 A 310.0 285.0 12 28 16 12 [[25, 289]] 1.0 5di1 Homo sapiens STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 5J95A O95819 14 309 1239.0 6HH:4000 Type1 Inactive DFGin 4.2418 13.5379 BLBplus -133.88, 158.51 61.23, 60.75 -96.39, 151.72 58.28, 90.54 -126.46, 999.0 in-in in 9.3928 Saltbr-in 3.0305 HRD-in -58.49, -50.73 79.94, -8.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -88.29, 128.45 APE9-dihe-na -81.99, -148.34 APE8-dihe-in -76.73, 130.72 APE8-rot-out 193.2 APE67-dihe-in -52.87, -25.48 -84.31, -21.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.0953 None None None XRAY 2.5 0.217 0.258 A 312.0 284.0 12 28 16 12 [[25, 289]] 1.0 5j95 Homo sapiens STE_MAP4K4_HUMAN STE 1.4e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4RVTA O95819 14 309 1239.0 3XM:401 Type1 Inactive DFGin 4.5855 13.4884 BLBplus -120.36, 165.4 61.54, 67.44 -121.04, 175.63 60.64, 92.85 148.07, 137.03 in-in in 9.033 Saltbr-in 2.9913 HRD-in -61.37, -42.25 71.33, 2.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -84.66, 129.17 APE9-dihe-na -79.09, -153.2 APE8-dihe-in -77.5, 135.48 APE8-rot-out 183.7 APE67-dihe-in -66.91, -20.37 -89.59, -9.54 APE12-dist-out 15.8779 APE11-dist-out 16.2082 APE10-dist-out 15.2156 APE9-dist-out 8.925 None None None XRAY 2.4 0.212 0.278 A 328.0 281.0 15 28 17 11 [[25, 289]] 1.0 4rvt Homo sapiens STE_MAP4K4_HUMAN STE 1.6e-102 348.2 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4OBOA O95819 16 310 1239.0 2QV:403 Type1 Inactive DFGin 4.8317 13.4495 BLBplus -140.76, 160.22 72.65, 57.21 -126.52, 139.47 80.19, 98.58 -105.22, 999.0 out-out out 11.6539 Saltbr-out 13.1245 HRD-in -69.62, -49.11 76.54, -12.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -107.35, 126.08 APE9-dihe-na -76.21, -153.35 APE8-dihe-in -73.39, 136.57 APE8-rot-out 191.35 APE67-dihe-in -55.68, -26.18 -93.03, -12.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4269 None None None XRAY 2.1 0.211 0.235 A 332.0 275.0 20 28 17 11 [[25, 289]] 1.0 4obo Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4OBQA O95819 16 311 1239.0 2QT:403 Type1 Inactive DFGin 4.041 13.1465 BLBplus -135.08, 157.4 64.12, 69.09 -116.53, 151.79 64.01, 94.51 149.44, -65.61 out-out out 10.5976 Saltbr-out 5.7413 HRD-in -68.06, -46.13 74.24, -12.59 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.88, 123.06 APE9-dihe-na -75.78, -148.16 APE8-dihe-in -76.95, 135.8 APE8-rot-out 192.58 APE67-dihe-in -60.09, -22.9 -91.57, -13.0 APE12-dist-in 12.6744 APE11-dist-in 11.7974 APE10-dist-out 12.3835 APE9-dist-out 9.1625 None None None XRAY 2.19 0.207 0.24 A 332.0 275.0 21 28 17 11 [[25, 289]] 1.0 4obq Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U41A O95819 16 310 1239.0 3C8:401 Type1 Inactive DFGin 4.5559 13.4666 BLBplus -138.61, 161.87 78.15, 25.36 -79.82, 151.09 70.06, 91.23 45.12, 999.0 out-out out 11.8383 Saltbr-out 12.0522 HRD-in -72.49, -61.04 87.54, -14.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -106.68, 129.18 APE9-dihe-na -77.17, -152.77 APE8-dihe-in -73.3, 139.87 APE8-rot-out 192.53 APE67-dihe-in -66.12, -22.6 -99.31, -3.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4526 None None None XRAY 2.2 0.203 0.259 A 332.0 275.0 20 28 17 11 [[25, 289]] 1.0 4u41 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U43A O95819 14 311 1239.0 3D8:401 Type1 Inactive DFGin 4.1532 13.2791 BLBplus -128.02, 167.59 53.52, 51.18 -89.85, 159.42 63.11, 99.17 62.64, 20.89 in-in in 9.4481 Saltbr-in 3.1166 HRD-in -63.88, -52.19 81.86, -10.5 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.17, 129.4 APE9-dihe-na -73.75, -152.4 APE8-dihe-in -76.21, 141.15 APE8-rot-out 189.14 APE67-dihe-in -55.54, -27.45 -95.27, -11.48 APE12-dist-in 13.1305 APE11-dist-in 12.0937 APE10-dist-out 12.5275 APE9-dist-out 8.5145 None None None XRAY 2.18 0.199 0.242 A 332.0 287.0 11 28 17 11 [[25, 289]] 1.0 4u43 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 5W5QA O95819 17 311 1239.0 9X4:401 Type1.5_Back Inactive DFGin 3.9393 13.418 BLBplus -132.02, 157.98 62.56, 44.92 -73.53, 143.63 61.83, 88.23 -61.33, 130.13 out-out out 11.1194 Saltbr-out 7.593 HRD-in -63.45, -47.09 75.06, -12.67 out-out-out SNCooo out-out ActLoopNT-out 10.2142 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -103.97, 125.84 APE9-dihe-na -77.42, -147.12 APE8-dihe-in -76.77, 136.92 APE8-rot-out 181.65 APE67-dihe-in -57.08, -24.3 -88.98, -16.47 APE12-dist-out 15.0412 APE11-dist-out 14.8528 APE10-dist-out 16.0807 APE9-dist-out 8.8907 None None None XRAY 2.33 0.211 0.235 A 332.0 291.0 4 28 28 0 [[25, 289]] 1.0 5w5q Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U3ZA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.504 10.1084 None -90.3, 128.59 75.45, 163.28 -151.97, 31.14 43.16, 85.73 119.13, -6.79 out-out out 13.9945 Saltbr-out 13.772 HRD-in -72.3, -49.26 78.71, -16.24 out-out-out SNCooo out-out ActLoopNT-out 5.3051 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.57, 126.67 APE9-dihe-na -83.8, -149.21 APE8-dihe-in -69.81, 136.64 APE8-rot-out 191.8 APE67-dihe-in -65.68, -25.19 -91.82, -5.09 APE12-dist-out 18.0443 APE11-dist-out 17.2286 APE10-dist-out 18.4608 APE9-dist-out 9.95 T181E None None XRAY 2.09 0.186 0.249 A 332.0 282.0 13 28 28 0 [[25, 289]] 1.0 4u3z Homo sapiens STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U3YA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.685 10.2954 None -88.99, 126.24 79.22, 151.13 -137.58, 35.87 48.82, 95.81 105.67, -5.01 out-out out 13.9033 Saltbr-out 14.4409 HRD-in -83.26, -53.16 70.55, 5.66 out-out-out SNCooo out-out ActLoopNT-out 5.7661 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.98, -47.61 APE9-dihe-na 95.3, -170.42 APE8-dihe-in -81.29, 138.53 APE8-rot-out 188.11 APE67-dihe-in -65.33, -22.86 -89.45, -12.96 APE12-dist-out 15.7712 APE11-dist-out 17.3079 APE10-dist-out 19.3169 APE9-dist-out 9.8362 None None None XRAY 1.45 0.184 0.207 A 332.0 295.0 0 28 28 0 [[25, 289]] 1.0 4u3y Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U3YB O95819 8 311 1239.0 No_ligand No_ligand Inactive DFGout 15.9836 4.7861 BBAminus -66.82, 136.69 -142.99, 93.73 -97.25, 33.21 286.77, 104.13 94.14, 55.99 out-out out 14.2412 Saltbr-out 11.968 HRD-in -69.2, -51.17 81.23, -14.38 out-out-out SNCooo out-out ActLoopNT-out 6.7383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -101.1, 129.97 APE9-dihe-na -81.01, -148.67 APE8-dihe-in -77.36, 139.73 APE8-rot-out 188.85 APE67-dihe-in -65.74, -23.58 -89.39, -13.52 APE12-dist-out 18.5642 APE11-dist-out 16.6679 APE10-dist-out 17.4754 APE9-dist-out 9.2719 None None None XRAY 1.45 0.184 0.207 B 332.0 300.0 4 28 28 0 [[25, 289]] 1.0 4u3y Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U3ZB O95819 14 311 1239.0 No_ligand No_ligand Inactive DFGout 16.3637 5.0186 None -61.71, 132.97 -142.2, 95.96 -99.94, 27.85 284.41, 110.75 76.81, -87.36 out-out out 14.2449 Saltbr-out 12.9437 HRD-in -72.98, -48.48 82.25, -12.79 out-out-out SNCooo out-out ActLoopNT-out 7.9083 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.13, -41.18 APE9-dihe-na 98.64, -167.9 APE8-dihe-in -91.19, 134.56 APE8-rot-out 184.77 APE67-dihe-in -58.28, -32.99 -88.54, -13.57 APE12-dist-out 14.9067 APE11-dist-out 15.2609 APE10-dist-out 17.5937 APE9-dist-out 9.505 T181E None None XRAY 2.09 0.186 0.249 B 332.0 294.0 4 28 28 0 [[25, 289]] 1.0 4u3z Homo sapiens STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4ZP5B O95819 10 309 1239.0 No_ligand No_ligand Inactive DFGout 16.4542 4.6876 None -64.64, 129.59 -138.51, 97.13 -106.95, 31.03 281.11, 111.35 97.44, 45.94 out-out out 14.5537 Saltbr-out 12.4413 HRD-in -65.77, -45.75 75.05, -12.45 out-out-out SNCooo out-out ActLoopNT-out 6.7588 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -58.03, -41.7 APE9-dihe-na 93.24, -171.79 APE8-dihe-in -74.39, 128.12 APE8-rot-out 190.93 APE67-dihe-in -47.46, -31.21 -87.26, -21.24 APE12-dist-out 18.9287 APE11-dist-out 17.7664 APE10-dist-out 18.651 APE9-dist-out 9.8972 None None None XRAY 2.29 0.231 0.264 B 309.0 300.0 0 28 28 0 [[25, 289]] 1.0 4zp5 Homo sapiens STE_MAP4K4_HUMAN STE 1.3e-102 348.5 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 5DI1B O95819 10 309 1239.0 No_ligand No_ligand Inactive DFGout 16.65 4.6926 None -66.94, 114.31 -129.18, 93.61 -101.31, 19.38 277.91, 108.92 116.45, 30.54 out-out out 14.1997 Saltbr-out 11.6069 HRD-in -63.56, -41.77 76.67, -20.55 out-out-out SNCooo out-out ActLoopNT-out 6.5825 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -51.73, -39.66 APE9-dihe-na 89.13, -169.86 APE8-dihe-in -77.09, 130.53 APE8-rot-out 194.93 APE67-dihe-in -46.23, -34.99 -85.22, -21.26 APE12-dist-out 18.5161 APE11-dist-out 17.4174 APE10-dist-out 18.3703 APE9-dist-out 9.9644 None None None XRAY 2.9 0.2 0.249 B 310.0 300.0 0 28 28 0 [[25, 289]] 1.0 5di1 Homo sapiens STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 5J95B O95819 10 309 1239.0 No_ligand No_ligand Inactive DFGout 16.7456 4.9523 None -64.71, 127.31 -142.47, 97.41 -109.0, 39.3 286.18, 99.3 87.98, 51.73 out-out out 14.5993 Saltbr-out 12.6468 HRD-in -63.81, -43.11 75.14, -8.54 out-out-out SNCooo out-out ActLoopNT-out 6.8052 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.17, -35.56 APE9-dihe-na 95.5, -178.39 APE8-dihe-in -77.01, 128.44 APE8-rot-out 195.18 APE67-dihe-in -52.87, -26.45 -82.63, -22.03 APE12-dist-out 18.7511 APE11-dist-out 17.3427 APE10-dist-out 18.3542 APE9-dist-out 9.5572 None None None XRAY 2.5 0.217 0.258 B 312.0 300.0 0 28 28 0 [[25, 289]] 1.0 5j95 Homo sapiens STE_MAP4K4_HUMAN STE 1.4e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 8V5IB O95819 16 311 1239.0 No_ligand No_ligand Inactive DFGout 16.3982 4.7739 None -64.57, 130.96 -143.69, 108.6 -121.09, 48.4 292.52, 92.46 85.4, 50.21 out-out out 14.7644 Saltbr-out 12.4066 HRD-in -69.53, -50.19 82.74, -16.12 out-out-out SNCooo out-out ActLoopNT-out 6.9023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.54, -33.43 APE9-dihe-na 91.78, -165.44 APE8-dihe-in -88.83, 131.09 APE8-rot-out 196.95 APE67-dihe-in -58.07, -26.81 -94.4, -14.8 APE12-dist-out 18.5475 APE11-dist-out 17.2708 APE10-dist-out 18.5983 APE9-dist-out 9.9307 None None None XRAY 2.18 0.25 0.281 B 320.0 288.0 8 28 28 0 [[25, 289]] 1.0 8v5i Homo sapiens STE_MAP4K4_HUMAN STE 1.5e-102 348.3 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4RVTB O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.6846 4.9727 None -62.7, 125.27 -136.33, 95.26 -98.1, 34.78 287.72, 112.93 97.52, 46.97 out-out out 15.2742 Saltbr-out 12.6039 HRD-in -66.59, -46.53 87.67, -15.84 out-out-out SNCooo out-out ActLoopNT-out 6.8824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.99, -29.45 APE9-dihe-na 84.04, -167.43 APE8-dihe-in -96.0, 129.43 APE8-rot-out 180.8 APE67-dihe-in -64.61, -28.12 -84.38, -17.27 APE12-dist-out 19.1017 APE11-dist-out 17.6296 APE10-dist-out 18.9428 APE9-dist-out 10.1714 None None None XRAY 2.4 0.212 0.278 B 328.0 297.0 2 28 28 0 [[25, 289]] 1.0 4rvt Homo sapiens STE_MAP4K4_HUMAN STE 1.6e-102 348.2 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4OBOB O95819 12 311 1239.0 No_ligand No_ligand Inactive DFGout 16.9129 4.6873 None -63.05, 130.05 -138.12, 97.92 -103.44, 31.91 283.52, 109.33 99.58, 56.89 out-out out 14.9404 Saltbr-out 13.3132 HRD-in -70.5, -47.99 76.13, -10.82 out-out-out SNCooo out-out ActLoopNT-out 6.7149 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.79, -38.18 APE9-dihe-na 92.33, -174.5 APE8-dihe-in -75.99, 132.78 APE8-rot-out 188.97 APE67-dihe-in -56.48, -27.21 -92.95, -11.65 APE12-dist-out 19.0154 APE11-dist-out 17.7139 APE10-dist-out 18.8623 APE9-dist-out 9.8873 None None None XRAY 2.1 0.211 0.235 B 332.0 297.0 3 28 28 0 [[25, 289]] 1.0 4obo Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4OBPB O95819 14 311 1239.0 No_ligand No_ligand Inactive DFGout 16.5534 4.9619 None -62.72, 128.65 -142.36, 99.68 -104.53, 30.43 285.25, 110.07 95.14, 56.71 out-out out 14.884 Saltbr-out 12.5472 HRD-in -64.48, -47.47 81.22, -20.24 out-out-out SNCooo out-out ActLoopNT-out 6.8943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.68, -34.65 APE9-dihe-na 85.15, -175.89 APE8-dihe-in -71.57, 131.05 APE8-rot-out 189.9 APE67-dihe-in -55.92, -31.18 -92.36, -12.02 APE12-dist-out 18.6917 APE11-dist-out 17.3709 APE10-dist-out 18.5839 APE9-dist-out 9.9472 None None None XRAY 2.27 0.206 0.247 B 332.0 290.0 8 28 28 0 [[25, 289]] 1.0 4obp Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4OBQB O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.7824 4.8378 None -65.54, 130.15 -138.36, 99.21 -108.3, 38.9 279.54, 113.84 89.61, 54.09 out-out out 14.4731 Saltbr-out 11.92 HRD-in -68.67, -45.56 74.55, -13.2 out-out-out SNCooo out-out ActLoopNT-out 6.7539 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.47, -36.9 APE9-dihe-na 88.64, -174.79 APE8-dihe-in -73.62, 132.18 APE8-rot-out 194.87 APE67-dihe-in -62.14, -25.0 -92.39, -12.75 APE12-dist-out 18.972 APE11-dist-out 17.016 APE10-dist-out 18.4004 APE9-dist-out 9.8147 None None None XRAY 2.19 0.207 0.24 B 332.0 293.0 6 28 28 0 [[25, 289]] 1.0 4obq Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U40B O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.9789 4.8603 None -58.33, 130.0 -140.04, 88.12 -92.84, 32.55 283.77, 110.6 100.78, 53.01 out-out out 15.1334 Saltbr-out 13.5311 HRD-in -74.7, -46.16 79.18, -17.97 out-out-out SNCooo out-out ActLoopNT-out 6.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.09, 129.36 APE9-dihe-na -87.21, -140.1 APE8-dihe-in -85.81, 130.5 APE8-rot-out 186.42 APE67-dihe-in -60.07, -29.15 -83.3, -16.35 APE12-dist-out 19.1266 APE11-dist-out 16.5875 APE10-dist-out 18.0955 APE9-dist-out 9.9159 None None None XRAY 2.3 0.201 0.262 B 332.0 299.0 0 28 28 0 [[25, 289]] 1.0 4u40 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U41B O95819 12 311 1239.0 No_ligand No_ligand Inactive DFGout 17.0636 5.0508 None -62.78, 130.42 -138.16, 96.26 -100.9, 39.01 294.93, 102.33 95.24, 62.11 out-out out 15.2882 Saltbr-out 13.1041 HRD-in -72.84, -48.94 82.78, -12.29 out-out-out SNCooo out-out ActLoopNT-out 6.8998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.17, -41.78 APE9-dihe-na 94.81, -169.92 APE8-dihe-in -89.48, 133.13 APE8-rot-out 186.04 APE67-dihe-in -63.4, -21.94 -91.46, -13.31 APE12-dist-out 18.8619 APE11-dist-out 17.5536 APE10-dist-out 18.7 APE9-dist-out 10.034 None None None XRAY 2.2 0.203 0.259 B 332.0 297.0 3 28 28 0 [[25, 289]] 1.0 4u41 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U43B O95819 10 311 1239.0 No_ligand No_ligand Inactive DFGout 16.2889 4.728 None -57.91, 126.01 -134.35, 92.48 -104.97, 41.66 281.52, 110.23 90.51, 59.66 out-out out 14.4356 Saltbr-out 13.0401 HRD-in -63.71, -51.88 82.9, -12.63 out-out-out SNCooo out-out ActLoopNT-out 6.9686 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.89, 129.63 APE9-dihe-na -74.53, -145.51 APE8-dihe-in -78.73, 137.83 APE8-rot-out 191.54 APE67-dihe-in -55.37, -28.59 -94.36, -10.33 APE12-dist-out 18.4658 APE11-dist-out 16.8971 APE10-dist-out 17.7292 APE9-dist-out 8.905 None None None XRAY 2.18 0.199 0.242 B 332.0 302.0 0 28 28 0 [[25, 289]] 1.0 4u43 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U44B O95819 14 311 1239.0 No_ligand No_ligand Inactive DFGout 17.3235 5.1579 None -66.19, 124.42 -129.8, 104.4 -108.16, 36.59 285.84, 114.28 95.97, 52.2 out-out out 15.1897 Saltbr-out 12.4272 HRD-in -74.8, -44.18 78.85, -14.34 out-out-out SNCooo out-out ActLoopNT-out 6.9068 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.22, -32.76 APE9-dihe-na 87.31, -162.41 APE8-dihe-in -88.16, 129.9 APE8-rot-out 203.29 APE67-dihe-in -66.88, -24.12 -90.95, -10.05 APE12-dist-out 18.7803 APE11-dist-out 17.1659 APE10-dist-out 18.4854 APE9-dist-out 10.0716 None None None XRAY 2.43 0.2 0.242 B 332.0 296.0 2 28 28 0 [[25, 289]] 1.0 4u44 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U45B O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.9584 4.9964 None -61.09, 130.9 -144.2, 101.4 -110.75, 46.12 286.45, 112.17 82.14, 51.37 out-out out 14.8572 Saltbr-out 12.1718 HRD-in -63.13, -45.9 75.3, -9.54 out-out-out SNCooo out-out ActLoopNT-out 6.8706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.5, -35.78 APE9-dihe-na 88.02, -170.58 APE8-dihe-in -75.79, 130.77 APE8-rot-out 191.37 APE67-dihe-in -60.13, -31.31 -89.68, -14.05 APE12-dist-out 18.7716 APE11-dist-out 17.608 APE10-dist-out 18.6925 APE9-dist-out 9.8227 None None None XRAY 2.58 0.197 0.244 B 332.0 295.0 4 28 28 0 [[25, 289]] 1.0 4u45 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4ZK5B O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.4947 5.1046 None -63.13, 129.25 -143.2, 101.72 -113.19, 44.1 293.79, 101.12 81.03, 58.31 out-out out 14.8357 Saltbr-out 12.562 HRD-in -67.58, -44.45 74.1, -16.4 out-out-out SNCooo out-out ActLoopNT-out 6.7885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -93.65, 113.34 APE9-dihe-na -72.51, -150.61 APE8-dihe-in -67.92, 128.89 APE8-rot-out 193.82 APE67-dihe-in -53.25, -26.28 -91.33, -20.14 APE12-dist-out 18.8718 APE11-dist-out 17.6074 APE10-dist-out 18.2462 APE9-dist-out 9.9036 None None None XRAY 2.89 0.215 0.265 B 332.0 294.0 5 28 28 0 [[25, 289]] 1.0 4zk5 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 5W5QB O95819 13 311 1239.0 No_ligand No_ligand Inactive DFGout 16.8719 5.2035 None -58.35, 131.39 -144.13, 97.43 -101.7, 28.86 285.52, 109.11 101.25, 47.95 out-out out 14.6483 Saltbr-out 12.422 HRD-in -68.93, -44.79 75.98, -15.73 out-out-out SNCooo out-out ActLoopNT-out 6.9666 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.14, -40.78 APE9-dihe-na 92.62, -172.13 APE8-dihe-in -78.44, 133.98 APE8-rot-out 181.47 APE67-dihe-in -57.39, -27.0 -90.37, -15.82 APE12-dist-out 18.7283 APE11-dist-out 17.1888 APE10-dist-out 18.3263 APE9-dist-out 9.8178 None None None XRAY 2.33 0.211 0.235 B 332.0 297.0 2 28 28 0 [[25, 289]] 1.0 5w5q Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 M4K4_HUMAN 4U42B O95819 17 310 1239.0 3C8:401 Type1 Inactive None 999.0 12.9041 None -137.73, 160.05 71.57, 38.3 -85.6, 128.16 56.27, 77.37 25.63, 81.69 none-none none 999.0 Saltbr-none 999.0 HRD-in -52.68, -50.82 83.11, -7.01 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.72, 121.45 APE9-dihe-na -84.48, -134.35 APE8-dihe-in -96.15, 130.99 APE8-rot-out 195.27 APE67-dihe-in -59.31, -29.62 -83.53, -22.99 APE12-dist-out 15.3781 APE11-dist-out 14.8056 APE10-dist-out 16.484 APE9-dist-out 9.7003 T181E None None XRAY 2.504 0.231 0.303 B 332.0 265.0 29 28 17 11 [[25, 289]] 1.0 4u42 Homo sapiens STE_MAP4K4_HUMAN STE 2.2e-102 347.7 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4

STE_MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name