TKL_LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)

Total number of chains: 42
Active chains: 7
Uniprot: LRRK2_HUMAN
Kinase Domain Residues: 1875 - 2134
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 12 28.6% 7LI4A
DFGin BLAminus 10 23.8% AF-Q5S007-K1A
DFGout BBAminus 8 19.0% 8U8AB
DFGin BLBplus 4 9.5% 6VP6A
DFGout None 4 9.5% 8FO9E
DFGin None 2 4.8% 8TZHA
None None 2 4.8% 8VH4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
8FO9A 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8FO9C 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
AF-Q5S007-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1867 - 2142 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
AF-Q5S007-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1867 - 2142 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8TXZA 3.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1N Type1 1334 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U7HC 3.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A0T Type1 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8TZCA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1N Type1 1333 - 2522 0 None G2019S Leucine-rich repeat serine/threonine-protein kinase 2
8SMCC 4.02 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii TVT Type1 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8FO7C 3.52 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4K4 Type1 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8TZGA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1N Type1 1333 - 2522 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2
6VP8A 3.5 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2
6VNOA 3.5 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2
6VP6A 3.47 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2
6VP7A 3.5 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2
8TZHA 3.9 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 627 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
9CHOA 7.8 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 543 - 2527 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2
7LHTA 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
7LHTB 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
7LHWA 3.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 540 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
7LI4A 3.1 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8FO2E 4.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8FO8C 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8FO8E 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8FO9F 3.48 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8VH5A 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8VH5C 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
7LI3A 3.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
9CI3A 3.96 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 907 - 2527 0 SEP910,SEP935 None Leucine-rich repeat serine/threonine-protein kinase 2
8TZBA 3.1 Inactive DFGout‑BBAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1334 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U7LA 3.6 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaini APEdist_nnno T3X Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U7LB 3.6 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaini APEdist_nnno T3X Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U8AB 3.4 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 0LI Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U8AC 3.4 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 0LI Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U8BA 3.7 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 919 Type2 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U8BB 3.7 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 919 Type2 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8TYQA 2.99 Inactive DFGout‑BBAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1335 - 2525 0 None G2019S Leucine-rich repeat serine/threonine-protein kinase 2
8FO9E 3.48 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
9DMIA 3.35 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnoi A1A7Q Type2 1334 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8TZEA 2.9 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1624 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8TZFA 3.4 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 587 - 2522 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2
8VH4A 4.1 Inactive None‑None out-none out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
8U1BA 3.7 Inactive None‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1952 - 2521 0 None None Leucine-rich repeat serine/threonine-protein kinase 2

TKL_LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)

Total number of chains: 42
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 12 28.6% 7LI4A
DFGin BLAminus 10 23.8% AF-Q5S007-K1A
DFGout BBAminus 8 19.0% 8U8AB
DFGin BLBplus 4 9.5% 6VP6A
DFGout None 4 9.5% 8FO9E
DFGin None 2 4.8% 8TZHA
None None 2 4.8% 8VH4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
LRRK2_HUMAN 8FO9A 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO9C 3.48 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN AF-Q5S007-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1867 - 2142 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN AF-Q5S007-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1867 - 2142 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TXZA 3.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1N Type1 1334 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U7HC 3.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A0T Type1 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TZCA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1N Type1 1333 - 2522 0 None G2019S Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8SMCC 4.02 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii TVT Type1 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO7C 3.52 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4K4 Type1 1329 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TZGA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii A1N Type1 1333 - 2522 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 6VP8A 3.5 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 6VNOA 3.5 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 6VP6A 3.47 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 6VP7A 3.5 Inactive DFGin‑BLBplus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1330 - 2525 0 TPO1343 None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TZHA 3.9 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 627 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 9CHOA 7.8 Inactive DFGin‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni A1N Type1 543 - 2527 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 7LHTA 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 7LHTB 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 7LHWA 3.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 540 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 7LI4A 3.1 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO2E 4.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO8C 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO8E 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO9F 3.48 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8VH5A 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8VH5C 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 7LI3A 3.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 9CI3A 3.96 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 907 - 2527 0 SEP910,SEP935 None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TZBA 3.1 Inactive DFGout‑BBAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1334 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U7LA 3.6 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaini APEdist_nnno T3X Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U7LB 3.6 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaini APEdist_nnno T3X Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U8AB 3.4 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 0LI Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U8AC 3.4 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 0LI Type2 558 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U8BA 3.7 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 919 Type2 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U8BB 3.7 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 919 Type2 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TYQA 2.99 Inactive DFGout‑BBAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1335 - 2525 0 None G2019S Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8FO9E 3.48 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 9DMIA 3.35 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnoi A1A7Q Type2 1334 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TZEA 2.9 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1624 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8TZFA 3.4 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 587 - 2522 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8VH4A 4.1 Inactive None‑None out-none out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
LRRK2_HUMAN 8U1BA 3.7 Inactive None‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1952 - 2521 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens

TKL_LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism