TYR_INSR (Insulin receptor)

Total number of chains: 26
Active chains: 7
Uniprot: INSR_HUMAN
Kinase Domain Residues: 1023 - 1292
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 38.5% AF-P06213-K1A
DFGin None 8 30.8% 5HHWA
DFGin ABAminus 4 15.4% 3BU6A
DFGout BBAminus 3 11.5% 1IRKA
None None 1 3.8% 8DWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
3BU5A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ATP ATPlike 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
4XLVA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 1001 - 1310 0 PTR999,PTR1185,PTR1189,PTR1190 Y992F,C1008S Insulin receptor
AF-P06213-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1015 - 1300 0 None None Insulin receptor
AF-P06213-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1015 - 1300 0 None None Insulin receptor
1GAGA 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1008 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor
1RQQA 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
1RQQB 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
2AUHA 3.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1011 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
2B4SB 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
2B4SD 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
3BU6A 1.95 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
1IR3A 1.9 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 1008 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor
3BU3A 1.65 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor
2Z8CA 3.25 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai S91 Type1 1011 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor
1I44A 2.4 Inactive DFGin‑None in-out none-out TYR APEdihe_nnoai APEdist_aaai ACP ATPlike 1013 - 1310 0 None C1008S,Y1011F,D1188A Insulin receptor
1P14A 1.9 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 1005 - 1310 0 None C1008S,D1159N Insulin receptor
4IBMA 1.8 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1009 - 1309 0 None K1278N Insulin receptor
4IBMB 1.8 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1014 - 1310 0 None K1278N Insulin receptor
5E1SA 2.264 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 5JA Type1 1010 - 1310 0 None None Insulin receptor
3EKKA 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_niiai APEdist_aaai GS2 Type1 1007 - 1309 0 None C1008S,D1159N Insulin receptor
3EKNA 2.2 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai GS3 Type1 1011 - 1310 0 None C1008S,D1159N Insulin receptor
5HHWA 1.79 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 60O Type1.5_Front 1005 - 1310 0 None C1008S,D1159N Insulin receptor
1IRKA 2.1 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1008 - 1310 0 None None Insulin receptor
3ETAA 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 351 Type2 1017 - 1310 0 None None Insulin receptor
3ETAB 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 351 Type2 1017 - 1310 0 None None Insulin receptor
8DWNA 2.15 Inactive None‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189 C1008S,Y1011F Insulin receptor

TYR_INSR (Insulin receptor)

Total number of chains: 26
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 38.5% AF-P06213-K1A
DFGin None 8 30.8% 5HHWA
DFGin ABAminus 4 15.4% 3BU6A
DFGout BBAminus 3 11.5% 1IRKA
None None 1 3.8% 8DWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
INSR_HUMAN 3BU5A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ATP ATPlike 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 4XLVA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 1001 - 1310 0 PTR999,PTR1185,PTR1189,PTR1190 Y992F,C1008S Insulin receptor Homo sapiens
INSR_HUMAN AF-P06213-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1015 - 1300 0 None None Insulin receptor Homo sapiens
INSR_HUMAN AF-P06213-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1015 - 1300 0 None None Insulin receptor Homo sapiens
INSR_HUMAN 1GAGA 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1008 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor Homo sapiens
INSR_HUMAN 1RQQA 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 1RQQB 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 2AUHA 3.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1011 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 2B4SB 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 2B4SD 2.3 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 3BU6A 1.95 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 1IR3A 1.9 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 1008 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor Homo sapiens
INSR_HUMAN 3BU3A 1.65 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S Insulin receptor Homo sapiens
INSR_HUMAN 2Z8CA 3.25 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai S91 Type1 1011 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor Homo sapiens
INSR_HUMAN 1I44A 2.4 Inactive DFGin‑None in-out none-out TYR APEdihe_nnoai APEdist_aaai ACP ATPlike 1013 - 1310 0 None C1008S,Y1011F,D1188A Insulin receptor Homo sapiens
INSR_HUMAN 1P14A 1.9 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 1005 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
INSR_HUMAN 4IBMA 1.8 Inactive DFGin‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1009 - 1309 0 None K1278N Insulin receptor Homo sapiens
INSR_HUMAN 4IBMB 1.8 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IR1 Type1 1014 - 1310 0 None K1278N Insulin receptor Homo sapiens
INSR_HUMAN 5E1SA 2.264 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 5JA Type1 1010 - 1310 0 None None Insulin receptor Homo sapiens
INSR_HUMAN 3EKKA 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_niiai APEdist_aaai GS2 Type1 1007 - 1309 0 None C1008S,D1159N Insulin receptor Homo sapiens
INSR_HUMAN 3EKNA 2.2 Inactive DFGin‑None in-out out-out TYR APEdihe_oiiai APEdist_aaai GS3 Type1 1011 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
INSR_HUMAN 5HHWA 1.79 Inactive DFGin‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 60O Type1.5_Front 1005 - 1310 0 None C1008S,D1159N Insulin receptor Homo sapiens
INSR_HUMAN 1IRKA 2.1 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1008 - 1310 0 None None Insulin receptor Homo sapiens
INSR_HUMAN 3ETAA 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 351 Type2 1017 - 1310 0 None None Insulin receptor Homo sapiens
INSR_HUMAN 3ETAB 2.6 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 351 Type2 1017 - 1310 0 None None Insulin receptor Homo sapiens
INSR_HUMAN 8DWNA 2.15 Inactive None‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1014 - 1310 0 PTR1185,PTR1189 C1008S,Y1011F Insulin receptor Homo sapiens

TYR_INSR (Insulin receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism