TYR_INSR (Insulin receptor)

Total number of chains: 26
Active chains: 7
Family: TYR
Uniprot: INSR_HUMAN
Kinase Domain Residues: 1023 - 1292
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 38.5% AF-P06213-K1A
DFGin None 8 30.8% 5HHWA
DFGin ABAminus 4 15.4% 3BU6A
DFGout BBAminus 3 11.5% 1IRKA
None None 1 3.8% 8DWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
3BU5A 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.659 13.934 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.261 Saltbr-in 3.13 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.937 APE11-dist-na 11.724 APE10-dist-na 11.3 APE9-dist-in 7.401 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306 294 3 0 0 0 [[1023, 1292]] 1.0 3bu5 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
4XLVA 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.357 13.404 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.175 Saltbr-in 2.441 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.741 APE11-dist-na 10.551 APE10-dist-na 11.027 APE9-dist-in 6.615 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328 310 0 0 0 0 [[1023, 1292]] 1.0 4xlv TYR_INSR_HUMAN TYR 1.7e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
AF-P06213-K1A 1015 1300 1382.0 No_ligand No_ligand Active DFGin 6.442 13.583 BLAminus -131.7, -172.45 45.37, 86.41 -94.16, 16.44 302.88, 99.36 -59.84, -31.96 in-in in 8.247 Saltbr-in 2.674 HRD-in -73.51, -42.55 67.15, -19.42 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.18, 137.66 APE9-dihe-in -134.51, 139.18 APE8-dihe-in -78.44, 64.7 APE8-rot-na 35.42 APE67-dihe-in -75.31, -12.73 -45.13, -39.55 APE12-dist-na 15.053 APE11-dist-na 10.969 APE10-dist-na 10.103 APE9-dist-in 7.04 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1023, 1292]] 1.0 AF-P06213-K1 TYR_INSR_HUMAN TYR 1.1e-96 329.0 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
AF-P06213-K3A 1015 1300 1382.0 No_ligand No_ligand Active DFGin 5.925 13.071 BLAminus -130.69, -170.6 46.9, 83.67 -94.17, 11.86 307.8, 94.97 -60.63, -30.18 in-in in 8.054 Saltbr-in 2.702 HRD-in -75.97, -44.42 67.04, -12.49 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.4, 144.11 APE9-dihe-in -144.36, 141.94 APE8-dihe-in -80.35, 60.58 APE8-rot-na 36.98 APE67-dihe-in -71.25, -11.2 -43.91, -40.1 APE12-dist-na 15.212 APE11-dist-na 11.338 APE10-dist-na 9.864 APE9-dist-in 6.777 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1023, 1292]] 1.0 AF-P06213-K3 TYR_INSR_HUMAN TYR 1.1e-96 329.0 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1GAGA 1008 1310 1382.0 No_ligand No_ligand Active DFGin 6.472 14.355 BLAminus -139.79, -163.29 39.42, 88.74 -105.4, 34.47 300.89, 100.42 -68.02, -37.48 in-in in 8.211 Saltbr-in 3.052 HRD-in -70.91, -47.43 72.33, -9.91 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.0, 110.5 APE9-dihe-in -118.5, 144.45 APE8-dihe-in -78.32, 65.87 APE8-rot-na 35.19 APE67-dihe-in -59.72, -1.72 -33.26, -57.54 APE12-dist-na 15.007 APE11-dist-na 10.753 APE10-dist-na 9.895 APE9-dist-in 6.926 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.7 0.214 0.269 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1gag TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1RQQA 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.304 13.655 BLAminus -139.27, -172.16 50.78, 88.11 -102.35, 26.03 306.58, 94.08 -57.3, -43.84 in-in in 7.845 Saltbr-in 2.74 HRD-in -71.1, -43.22 70.05, -11.76 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.1, 113.79 APE9-dihe-in -119.85, 145.04 APE8-dihe-in -81.27, 63.72 APE8-rot-na 35.79 APE67-dihe-in -62.06, -15.17 -39.6, -48.57 APE12-dist-na 14.863 APE11-dist-na 10.683 APE10-dist-na 9.766 APE9-dist-in 6.891 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 A 306 297 0 0 0 0 [[1023, 1292]] 1.0 1rqq TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1RQQB 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.426 13.787 BLAminus -137.51, -169.29 49.47, 88.05 -100.38, 24.24 303.21, 103.09 -57.34, -45.05 in-in in 7.85 Saltbr-in 3.251 HRD-in -70.29, -44.51 70.11, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.8, 112.61 APE9-dihe-in -120.76, 146.23 APE8-dihe-in -80.75, 64.53 APE8-rot-na 38.22 APE67-dihe-in -64.56, -12.7 -44.47, -42.91 APE12-dist-na 14.878 APE11-dist-na 10.717 APE10-dist-na 9.747 APE9-dist-in 6.862 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 B 306 297 0 0 0 0 [[1023, 1292]] 1.0 1rqq TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
2AUHA 1011 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.141 13.65 ABAminus -136.58, -4.55 -122.41, 138.22 -136.1, 17.13 297.74, 110.36 -54.48, -33.89 in-in in 8.404 Saltbr-in 2.705 HRD-in -71.8, -48.89 72.15, -21.21 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.66, 123.66 APE9-dihe-in -133.04, 151.36 APE8-dihe-in -70.19, 59.35 APE8-rot-na 32.97 APE67-dihe-in -65.61, -7.78 -36.89, -48.67 APE12-dist-na 15.4 APE11-dist-na 11.146 APE10-dist-na 9.877 APE9-dist-in 6.757 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.2 0.223 0.254 A 306 300 0 0 0 0 [[1023, 1292]] 1.0 2auh TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
2B4SB 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.479 13.82 ABAminus -125.78, 6.45 -136.21, 138.63 -137.01, 36.1 305.43, 85.48 -62.07, -22.25 in-in in 8.045 Saltbr-in 3.586 HRD-in -75.2, -47.87 71.7, -18.35 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.64, 128.11 APE9-dihe-in -127.63, 149.14 APE8-dihe-in -79.25, 69.85 APE8-rot-na 37.38 APE67-dihe-in -66.83, -13.89 -42.23, -45.27 APE12-dist-na 15.035 APE11-dist-na 11.289 APE10-dist-na 10.936 APE9-dist-in 7.457 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 B 306 297 0 0 0 0 [[1023, 1292]] 1.0 2b4s TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
2B4SD 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.592 14.088 ABAminus -130.66, 15.42 -144.64, 123.77 -125.26, 40.8 306.28, 76.94 -64.15, -16.22 in-in in 7.981 Saltbr-in 2.648 HRD-in -75.91, -45.41 68.78, -17.89 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.77, 132.95 APE9-dihe-in -133.75, 151.9 APE8-dihe-in -79.94, 78.72 APE8-rot-na 36.75 APE67-dihe-in -73.63, -5.75 -50.54, -37.22 APE12-dist-na 14.815 APE11-dist-na 11.464 APE10-dist-na 11.398 APE9-dist-in 7.409 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 D 306 297 0 0 0 0 [[1023, 1292]] 1.0 2b4s TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
3BU6A 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.982 14.004 ABAminus -127.49, -6.05 -146.78, 128.5 -126.39, 29.26 301.19, 85.56 -62.37, -9.3 in-in in 8.251 Saltbr-in 3.56 HRD-in -76.09, -48.83 72.52, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.83, 102.44 APE9-dihe-in -128.25, 150.85 APE8-dihe-in -77.03, 62.98 APE8-rot-na 32.44 APE67-dihe-in -72.83, -9.55 -48.55, -39.5 APE12-dist-na 16.122 APE11-dist-na 12.076 APE10-dist-na 11.746 APE9-dist-in 7.74 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.95 0.202 0.239 A 306 297 0 0 0 0 [[1023, 1292]] 1.0 3bu6 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1IR3A 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.128 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.923 Saltbr-out 4.393 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.511 APE11-dist-na 10.427 APE10-dist-na 9.764 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1ir3 TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
3BU3A 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.831 14.318 BLAminus -125.34, -173.11 49.37, 91.34 -105.76, 28.79 293.31, 96.09 -61.52, -23.48 in-out in 8.334 Saltbr-out 3.643 HRD-in -77.13, -47.35 74.01, -9.17 out-in-in SNCoii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.87, 102.94 APE9-dihe-in -129.84, 150.89 APE8-dihe-in -79.69, 65.67 APE8-rot-na 33.39 APE67-dihe-in -69.85, -9.41 -51.56, -40.22 APE12-dist-na 15.814 APE11-dist-na 11.584 APE10-dist-na 11.082 APE9-dist-in 7.37 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.65 0.203 0.22 A 306 297 0 0 0 0 [[1023, 1292]] 1.0 3bu3 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
2Z8CA 1011 1310 1382.0 S91:60001 Type1 Inactive DFGin 6.401 12.923 BLAminus -126.28, -180.0 45.53, 101.6 -113.26, 32.07 305.0, 102.45 -55.7, -35.78 in-out in 7.478 Saltbr-out 3.627 HRD-in -88.34, -29.28 53.1, 14.66 out-in-in SNCoii in-in ActLoopNT-in 2.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.92, 127.58 APE9-dihe-in -136.04, 148.74 APE8-dihe-in -92.61, 86.13 APE8-rot-na 40.99 APE67-dihe-in -57.55, -15.17 -59.74, -44.88 APE12-dist-na 14.522 APE11-dist-na 10.602 APE10-dist-na 9.764 APE9-dist-in 6.883 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.25 0.217 0.292 A 303 300 0 0 0 0 [[1023, 1292]] 1.0 2z8c TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1I44A 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.641 13.72 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.895 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.683 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306 282 16 0 0 16 [[1023, 1292]] 1.0 1i44 TYR_INSR_HUMAN TYR 3.4e-96 327.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1P14A 1005 1310 1382.0 No_ligand No_ligand Inactive DFGin 7.611 15.344 None -93.61, -127.04 -78.93, 153.19 -166.81, 155.93 65.2, 94.97 -69.26, 999.0 in-out in 9.251 Saltbr-out 5.47 HRD-in -68.39, -55.7 74.95, -11.95 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.41 APE8-rot-na 37.98 APE67-dihe-in -68.35, -7.74 -43.78, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1008S,D1159N None None XRAY 1.9 0.225 0.24 A 306 287 19 0 0 19 [[1023, 1292]] 1.0 1p14 TYR_INSR_HUMAN TYR 5e-96 326.9 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
4IBMA 1009 1309 1382.0 IR1:61301 Type1 Inactive DFGin 5.623 15.313 None -76.0, 163.85 -44.82, 128.63 -69.67, 135.99 297.32, 165.57 60.17, 44.87 out-out out 10.645 Saltbr-out 7.271 HRD-in -68.74, -46.51 75.22, -15.25 out-out-in SNCooi out-in ActLoopNT-out 15.665 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 121.44 APE9-dihe-in -109.91, 120.82 APE8-dihe-in -81.27, 70.1 APE8-rot-na 28.73 APE67-dihe-in -71.57, -11.47 -57.01, -32.73 APE12-dist-na 18.738 APE11-dist-na 15.274 APE10-dist-na 11.506 APE9-dist-in 7.314 K1278N None None XRAY 1.8 0.184 0.218 A 306 301 0 0 0 0 [[1023, 1292]] 1.0 4ibm TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
4IBMB 1014 1310 1382.0 IR1:61301 Type1 Inactive DFGin 6.943 16.445 None -69.6, 155.55 -45.67, 125.47 -61.25, 129.45 282.72, 8.49 78.34, 8.83 in-out in 9.418 Saltbr-out 5.034 HRD-in -66.87, -50.14 74.82, -11.33 out-out-in SNCooi out-in ActLoopNT-out 15.222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 122.58 APE9-dihe-in -120.44, 134.35 APE8-dihe-in -81.79, 69.08 APE8-rot-na 32.76 APE67-dihe-in -70.68, -10.48 -58.86, -32.74 APE12-dist-na 19.958 APE11-dist-na 16.309 APE10-dist-na 12.665 APE9-dist-in 7.306 K1278N None None XRAY 1.8 0.184 0.218 B 306 294 3 0 0 0 [[1023, 1292]] 1.0 4ibm TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
5E1SA 1010 1310 1382.0 5JA:61301 Type1 Inactive DFGin 6.865 15.09 None -82.55, -126.51 -82.76, 146.74 -146.5, 173.12 61.91, 96.0 -67.13, 97.4 in-out in 8.833 Saltbr-out 6.372 HRD-in -66.03, -52.34 70.18, -7.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -78.62, 65.27 APE8-rot-na 31.33 APE67-dihe-in -70.73, -11.27 -48.96, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.325 None None None XRAY 2.264 0.215 0.262 A 308 284 17 0 0 17 [[1023, 1292]] 1.0 5e1s TYR_INSR_HUMAN TYR 5.6e-96 326.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
3EKKA 1007 1309 1382.0 GS2:60001 Type1 Inactive DFGin 6.932 15.262 None -91.44, -126.11 -77.81, 134.04 -139.23, 999.0 58.35, 102.32 999.0, 999.0 in-out in 9.287 Saltbr-out 5.33 HRD-in -69.72, -54.17 78.3, -13.96 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -25.52 APE9-dihe-in -83.53, 136.03 APE8-dihe-in -85.94, 70.21 APE8-rot-na 27.34 APE67-dihe-in -74.98, -12.32 -58.97, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.525 C1008S,D1159N None None XRAY 2.1 0.207 0.26 A 307 285 18 0 0 18 [[1023, 1292]] 1.0 3ekk TYR_INSR_HUMAN TYR 5.1e-96 326.9 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
3EKNA 1011 1310 1382.0 GS3:60001 Type1 Inactive DFGin 6.247 13.354 None -59.53, -41.76 -156.68, -173.98 -81.39, 6.66 55.61, 95.58 69.22, 37.13 in-out in 8.486 Saltbr-out 4.158 HRD-in -69.98, -55.95 75.05, -7.0 out-out-out SNCooo out-out ActLoopNT-out 9.48 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.36, -23.41 APE9-dihe-in -94.03, 128.42 APE8-dihe-in -84.32, 117.17 APE8-rot-na 4.91 APE67-dihe-in -79.33, -4.28 -67.04, -22.99 APE12-dist-na 999.0 APE11-dist-na 13.712 APE10-dist-na 9.237 APE9-dist-in 4.827 C1008S,D1159N None None XRAY 2.2 0.214 0.274 A 307 297 3 0 0 3 [[1023, 1292]] 1.0 3ekn TYR_INSR_HUMAN TYR 5.1e-96 326.9 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
5HHWA 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.547 15.218 None -93.96, -126.86 -75.33, 119.05 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.644 Saltbr-out 6.203 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.71 APE11-dist-na 10.945 APE10-dist-na 9.756 APE9-dist-in 7.506 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307 306 0 0 0 0 [[1023, 1292]] 1.0 5hhw TYR_INSR_HUMAN TYR 5.5e-96 326.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
1IRKA 1008 1310 1382.0 No_ligand No_ligand Inactive DFGout 14.11 8.254 BBAminus 170.32, 146.4 -160.79, 149.25 -78.89, -23.45 305.87, 140.64 112.61, 49.94 in-out in 9.314 Saltbr-out 5.963 HRD-in -57.78, -53.43 77.45, -13.51 out-out-in SNCooi out-in ActLoopNT-out 17.182 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.89, 110.6 APE9-dihe-in -117.78, 141.32 APE8-dihe-in -78.03, 65.06 APE8-rot-na 33.68 APE67-dihe-in -72.48, -5.73 -49.44, -39.24 APE12-dist-na 19.192 APE11-dist-na 15.044 APE10-dist-na 10.815 APE9-dist-in 7.458 None None None XRAY 2.1 0.196 0.232 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1irk TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
3ETAA 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.796 11.013 BBAminus -132.13, -174.21 -157.85, 103.42 -76.03, -16.02 293.96, 86.44 92.76, -168.27 in-in in 8.322 Saltbr-in 2.757 HRD-in -66.68, -47.32 76.44, -15.87 in-out-in SNCioi out-in ActLoopNT-out 17.826 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.11, 133.17 APE9-dihe-in -138.51, 142.25 APE8-dihe-in -82.26, 68.13 APE8-rot-na 29.26 APE67-dihe-in -71.63, -9.4 -61.34, -31.95 APE12-dist-na 14.303 APE11-dist-na 10.211 APE10-dist-na 6.041 APE9-dist-in 7.145 None None None XRAY 2.6 0.203 0.232 A 317 293 1 0 0 1 [[1023, 1292]] 1.0 3eta TYR_INSR_HUMAN TYR 1.6e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
3ETAB 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.917 11.175 BBAminus -133.15, -176.66 -152.04, 106.96 -74.04, -41.1 283.79, 91.95 126.4, -175.96 in-in in 8.351 Saltbr-in 3.111 HRD-in -71.49, -47.77 78.43, -20.3 in-out-in SNCioi out-in ActLoopNT-out 17.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.8, 131.91 APE9-dihe-in -139.37, 136.91 APE8-dihe-in -77.51, 68.63 APE8-rot-na 28.59 APE67-dihe-in -74.17, -10.01 -54.55, -36.82 APE12-dist-na 14.326 APE11-dist-na 10.173 APE10-dist-na 5.896 APE9-dist-in 7.247 None None None XRAY 2.6 0.203 0.232 B 317 292 2 0 0 2 [[1023, 1292]] 1.0 3eta TYR_INSR_HUMAN TYR 1.6e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
8DWNA 1014 1310 1382.0 No_ligand No_ligand Inactive None 999.0 999.0 None -95.48, -147.03 167.35, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.184 Saltbr-out 6.094 HRD-in -65.71, -54.25 86.56, -19.69 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.95, 141.67 APE9-dihe-in -121.95, 127.79 APE8-dihe-in -80.86, 78.35 APE8-rot-na 32.73 APE67-dihe-in -73.46, -9.67 -56.68, -44.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2 C1008S,Y1011F PTR1185,PTR1189 PTR1185,PTR1189 XRAY 2.15 0.195 0.247 A 306 286 11 0 0 11 [[1023, 1292]] 1.0 8dwn TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor

TYR_INSR (Insulin receptor)

Total number of chains: 26
Active chains: 7
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 38.5% AF-P06213-K1A
DFGin None 8 30.8% 5HHWA
DFGin ABAminus 4 15.4% 3BU6A
DFGout BBAminus 3 11.5% 1IRKA
None None 1 3.8% 8DWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
INSR_HUMAN 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.659 13.934 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.261 Saltbr-in 3.13 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.937 APE11-dist-na 11.724 APE10-dist-na 11.3 APE9-dist-in 7.401 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306 294 3 0 0 0 [[1023, 1292]] 1.0 3bu5 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.357 13.404 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.175 Saltbr-in 2.441 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.741 APE11-dist-na 10.551 APE10-dist-na 11.027 APE9-dist-in 6.615 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328 310 0 0 0 0 [[1023, 1292]] 1.0 4xlv Homo sapiens TYR_INSR_HUMAN TYR 1.7e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN AF-P06213-K1A P06213 1015 1300 1382.0 No_ligand No_ligand Active DFGin 6.442 13.583 BLAminus -131.7, -172.45 45.37, 86.41 -94.16, 16.44 302.88, 99.36 -59.84, -31.96 in-in in 8.247 Saltbr-in 2.674 HRD-in -73.51, -42.55 67.15, -19.42 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.18, 137.66 APE9-dihe-in -134.51, 139.18 APE8-dihe-in -78.44, 64.7 APE8-rot-na 35.42 APE67-dihe-in -75.31, -12.73 -45.13, -39.55 APE12-dist-na 15.053 APE11-dist-na 10.969 APE10-dist-na 10.103 APE9-dist-in 7.04 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1023, 1292]] 1.0 AF-P06213-K1 Homo sapiens TYR_INSR_HUMAN TYR 1.1e-96 329.0 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN AF-P06213-K3A P06213 1015 1300 1382.0 No_ligand No_ligand Active DFGin 5.925 13.071 BLAminus -130.69, -170.6 46.9, 83.67 -94.17, 11.86 307.8, 94.97 -60.63, -30.18 in-in in 8.054 Saltbr-in 2.702 HRD-in -75.97, -44.42 67.04, -12.49 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.4, 144.11 APE9-dihe-in -144.36, 141.94 APE8-dihe-in -80.35, 60.58 APE8-rot-na 36.98 APE67-dihe-in -71.25, -11.2 -43.91, -40.1 APE12-dist-na 15.212 APE11-dist-na 11.338 APE10-dist-na 9.864 APE9-dist-in 6.777 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[1023, 1292]] 1.0 AF-P06213-K3 Homo sapiens TYR_INSR_HUMAN TYR 1.1e-96 329.0 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1GAGA P06213 1008 1310 1382.0 No_ligand No_ligand Active DFGin 6.472 14.355 BLAminus -139.79, -163.29 39.42, 88.74 -105.4, 34.47 300.89, 100.42 -68.02, -37.48 in-in in 8.211 Saltbr-in 3.052 HRD-in -70.91, -47.43 72.33, -9.91 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.0, 110.5 APE9-dihe-in -118.5, 144.45 APE8-dihe-in -78.32, 65.87 APE8-rot-na 35.19 APE67-dihe-in -59.72, -1.72 -33.26, -57.54 APE12-dist-na 15.007 APE11-dist-na 10.753 APE10-dist-na 9.895 APE9-dist-in 6.926 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.7 0.214 0.269 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1gag Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1RQQA P06213 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.304 13.655 BLAminus -139.27, -172.16 50.78, 88.11 -102.35, 26.03 306.58, 94.08 -57.3, -43.84 in-in in 7.845 Saltbr-in 2.74 HRD-in -71.1, -43.22 70.05, -11.76 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.1, 113.79 APE9-dihe-in -119.85, 145.04 APE8-dihe-in -81.27, 63.72 APE8-rot-na 35.79 APE67-dihe-in -62.06, -15.17 -39.6, -48.57 APE12-dist-na 14.863 APE11-dist-na 10.683 APE10-dist-na 9.766 APE9-dist-in 6.891 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 A 306 297 0 0 0 0 [[1023, 1292]] 1.0 1rqq Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1RQQB P06213 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.426 13.787 BLAminus -137.51, -169.29 49.47, 88.05 -100.38, 24.24 303.21, 103.09 -57.34, -45.05 in-in in 7.85 Saltbr-in 3.251 HRD-in -70.29, -44.51 70.11, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.8, 112.61 APE9-dihe-in -120.76, 146.23 APE8-dihe-in -80.75, 64.53 APE8-rot-na 38.22 APE67-dihe-in -64.56, -12.7 -44.47, -42.91 APE12-dist-na 14.878 APE11-dist-na 10.717 APE10-dist-na 9.747 APE9-dist-in 6.862 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 B 306 297 0 0 0 0 [[1023, 1292]] 1.0 1rqq Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 2AUHA P06213 1011 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.141 13.65 ABAminus -136.58, -4.55 -122.41, 138.22 -136.1, 17.13 297.74, 110.36 -54.48, -33.89 in-in in 8.404 Saltbr-in 2.705 HRD-in -71.8, -48.89 72.15, -21.21 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.66, 123.66 APE9-dihe-in -133.04, 151.36 APE8-dihe-in -70.19, 59.35 APE8-rot-na 32.97 APE67-dihe-in -65.61, -7.78 -36.89, -48.67 APE12-dist-na 15.4 APE11-dist-na 11.146 APE10-dist-na 9.877 APE9-dist-in 6.757 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.2 0.223 0.254 A 306 300 0 0 0 0 [[1023, 1292]] 1.0 2auh Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 2B4SB P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.479 13.82 ABAminus -125.78, 6.45 -136.21, 138.63 -137.01, 36.1 305.43, 85.48 -62.07, -22.25 in-in in 8.045 Saltbr-in 3.586 HRD-in -75.2, -47.87 71.7, -18.35 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.64, 128.11 APE9-dihe-in -127.63, 149.14 APE8-dihe-in -79.25, 69.85 APE8-rot-na 37.38 APE67-dihe-in -66.83, -13.89 -42.23, -45.27 APE12-dist-na 15.035 APE11-dist-na 11.289 APE10-dist-na 10.936 APE9-dist-in 7.457 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 B 306 297 0 0 0 0 [[1023, 1292]] 1.0 2b4s Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 2B4SD P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.592 14.088 ABAminus -130.66, 15.42 -144.64, 123.77 -125.26, 40.8 306.28, 76.94 -64.15, -16.22 in-in in 7.981 Saltbr-in 2.648 HRD-in -75.91, -45.41 68.78, -17.89 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.77, 132.95 APE9-dihe-in -133.75, 151.9 APE8-dihe-in -79.94, 78.72 APE8-rot-na 36.75 APE67-dihe-in -73.63, -5.75 -50.54, -37.22 APE12-dist-na 14.815 APE11-dist-na 11.464 APE10-dist-na 11.398 APE9-dist-in 7.409 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 D 306 297 0 0 0 0 [[1023, 1292]] 1.0 2b4s Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 3BU6A P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.982 14.004 ABAminus -127.49, -6.05 -146.78, 128.5 -126.39, 29.26 301.19, 85.56 -62.37, -9.3 in-in in 8.251 Saltbr-in 3.56 HRD-in -76.09, -48.83 72.52, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.83, 102.44 APE9-dihe-in -128.25, 150.85 APE8-dihe-in -77.03, 62.98 APE8-rot-na 32.44 APE67-dihe-in -72.83, -9.55 -48.55, -39.5 APE12-dist-na 16.122 APE11-dist-na 12.076 APE10-dist-na 11.746 APE9-dist-in 7.74 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.95 0.202 0.239 A 306 297 0 0 0 0 [[1023, 1292]] 1.0 3bu6 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.128 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.923 Saltbr-out 4.393 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.511 APE11-dist-na 10.427 APE10-dist-na 9.764 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1ir3 Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 3BU3A P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.831 14.318 BLAminus -125.34, -173.11 49.37, 91.34 -105.76, 28.79 293.31, 96.09 -61.52, -23.48 in-out in 8.334 Saltbr-out 3.643 HRD-in -77.13, -47.35 74.01, -9.17 out-in-in SNCoii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.87, 102.94 APE9-dihe-in -129.84, 150.89 APE8-dihe-in -79.69, 65.67 APE8-rot-na 33.39 APE67-dihe-in -69.85, -9.41 -51.56, -40.22 APE12-dist-na 15.814 APE11-dist-na 11.584 APE10-dist-na 11.082 APE9-dist-in 7.37 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.65 0.203 0.22 A 306 297 0 0 0 0 [[1023, 1292]] 1.0 3bu3 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 2Z8CA P06213 1011 1310 1382.0 S91:60001 Type1 Inactive DFGin 6.401 12.923 BLAminus -126.28, -180.0 45.53, 101.6 -113.26, 32.07 305.0, 102.45 -55.7, -35.78 in-out in 7.478 Saltbr-out 3.627 HRD-in -88.34, -29.28 53.1, 14.66 out-in-in SNCoii in-in ActLoopNT-in 2.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.92, 127.58 APE9-dihe-in -136.04, 148.74 APE8-dihe-in -92.61, 86.13 APE8-rot-na 40.99 APE67-dihe-in -57.55, -15.17 -59.74, -44.88 APE12-dist-na 14.522 APE11-dist-na 10.602 APE10-dist-na 9.764 APE9-dist-in 6.883 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.25 0.217 0.292 A 303 300 0 0 0 0 [[1023, 1292]] 1.0 2z8c Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.641 13.72 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.895 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.683 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306 282 16 0 0 16 [[1023, 1292]] 1.0 1i44 Homo sapiens TYR_INSR_HUMAN TYR 3.4e-96 327.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1P14A P06213 1005 1310 1382.0 No_ligand No_ligand Inactive DFGin 7.611 15.344 None -93.61, -127.04 -78.93, 153.19 -166.81, 155.93 65.2, 94.97 -69.26, 999.0 in-out in 9.251 Saltbr-out 5.47 HRD-in -68.39, -55.7 74.95, -11.95 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.41 APE8-rot-na 37.98 APE67-dihe-in -68.35, -7.74 -43.78, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1008S,D1159N None None XRAY 1.9 0.225 0.24 A 306 287 19 0 0 19 [[1023, 1292]] 1.0 1p14 Homo sapiens TYR_INSR_HUMAN TYR 5e-96 326.9 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 4IBMA P06213 1009 1309 1382.0 IR1:61301 Type1 Inactive DFGin 5.623 15.313 None -76.0, 163.85 -44.82, 128.63 -69.67, 135.99 297.32, 165.57 60.17, 44.87 out-out out 10.645 Saltbr-out 7.271 HRD-in -68.74, -46.51 75.22, -15.25 out-out-in SNCooi out-in ActLoopNT-out 15.665 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 121.44 APE9-dihe-in -109.91, 120.82 APE8-dihe-in -81.27, 70.1 APE8-rot-na 28.73 APE67-dihe-in -71.57, -11.47 -57.01, -32.73 APE12-dist-na 18.738 APE11-dist-na 15.274 APE10-dist-na 11.506 APE9-dist-in 7.314 K1278N None None XRAY 1.8 0.184 0.218 A 306 301 0 0 0 0 [[1023, 1292]] 1.0 4ibm Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 4IBMB P06213 1014 1310 1382.0 IR1:61301 Type1 Inactive DFGin 6.943 16.445 None -69.6, 155.55 -45.67, 125.47 -61.25, 129.45 282.72, 8.49 78.34, 8.83 in-out in 9.418 Saltbr-out 5.034 HRD-in -66.87, -50.14 74.82, -11.33 out-out-in SNCooi out-in ActLoopNT-out 15.222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 122.58 APE9-dihe-in -120.44, 134.35 APE8-dihe-in -81.79, 69.08 APE8-rot-na 32.76 APE67-dihe-in -70.68, -10.48 -58.86, -32.74 APE12-dist-na 19.958 APE11-dist-na 16.309 APE10-dist-na 12.665 APE9-dist-in 7.306 K1278N None None XRAY 1.8 0.184 0.218 B 306 294 3 0 0 0 [[1023, 1292]] 1.0 4ibm Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 5E1SA P06213 1010 1310 1382.0 5JA:61301 Type1 Inactive DFGin 6.865 15.09 None -82.55, -126.51 -82.76, 146.74 -146.5, 173.12 61.91, 96.0 -67.13, 97.4 in-out in 8.833 Saltbr-out 6.372 HRD-in -66.03, -52.34 70.18, -7.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -78.62, 65.27 APE8-rot-na 31.33 APE67-dihe-in -70.73, -11.27 -48.96, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.325 None None None XRAY 2.264 0.215 0.262 A 308 284 17 0 0 17 [[1023, 1292]] 1.0 5e1s Homo sapiens TYR_INSR_HUMAN TYR 5.6e-96 326.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 3EKKA P06213 1007 1309 1382.0 GS2:60001 Type1 Inactive DFGin 6.932 15.262 None -91.44, -126.11 -77.81, 134.04 -139.23, 999.0 58.35, 102.32 999.0, 999.0 in-out in 9.287 Saltbr-out 5.33 HRD-in -69.72, -54.17 78.3, -13.96 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -25.52 APE9-dihe-in -83.53, 136.03 APE8-dihe-in -85.94, 70.21 APE8-rot-na 27.34 APE67-dihe-in -74.98, -12.32 -58.97, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.525 C1008S,D1159N None None XRAY 2.1 0.207 0.26 A 307 285 18 0 0 18 [[1023, 1292]] 1.0 3ekk Homo sapiens TYR_INSR_HUMAN TYR 5.1e-96 326.9 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 3EKNA P06213 1011 1310 1382.0 GS3:60001 Type1 Inactive DFGin 6.247 13.354 None -59.53, -41.76 -156.68, -173.98 -81.39, 6.66 55.61, 95.58 69.22, 37.13 in-out in 8.486 Saltbr-out 4.158 HRD-in -69.98, -55.95 75.05, -7.0 out-out-out SNCooo out-out ActLoopNT-out 9.48 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.36, -23.41 APE9-dihe-in -94.03, 128.42 APE8-dihe-in -84.32, 117.17 APE8-rot-na 4.91 APE67-dihe-in -79.33, -4.28 -67.04, -22.99 APE12-dist-na 999.0 APE11-dist-na 13.712 APE10-dist-na 9.237 APE9-dist-in 4.827 C1008S,D1159N None None XRAY 2.2 0.214 0.274 A 307 297 3 0 0 3 [[1023, 1292]] 1.0 3ekn Homo sapiens TYR_INSR_HUMAN TYR 5.1e-96 326.9 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.547 15.218 None -93.96, -126.86 -75.33, 119.05 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.644 Saltbr-out 6.203 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.71 APE11-dist-na 10.945 APE10-dist-na 9.756 APE9-dist-in 7.506 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307 306 0 0 0 0 [[1023, 1292]] 1.0 5hhw Homo sapiens TYR_INSR_HUMAN TYR 5.5e-96 326.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 1IRKA P06213 1008 1310 1382.0 No_ligand No_ligand Inactive DFGout 14.11 8.254 BBAminus 170.32, 146.4 -160.79, 149.25 -78.89, -23.45 305.87, 140.64 112.61, 49.94 in-out in 9.314 Saltbr-out 5.963 HRD-in -57.78, -53.43 77.45, -13.51 out-out-in SNCooi out-in ActLoopNT-out 17.182 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.89, 110.6 APE9-dihe-in -117.78, 141.32 APE8-dihe-in -78.03, 65.06 APE8-rot-na 33.68 APE67-dihe-in -72.48, -5.73 -49.44, -39.24 APE12-dist-na 19.192 APE11-dist-na 15.044 APE10-dist-na 10.815 APE9-dist-in 7.458 None None None XRAY 2.1 0.196 0.232 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1irk Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 3ETAA P06213 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.796 11.013 BBAminus -132.13, -174.21 -157.85, 103.42 -76.03, -16.02 293.96, 86.44 92.76, -168.27 in-in in 8.322 Saltbr-in 2.757 HRD-in -66.68, -47.32 76.44, -15.87 in-out-in SNCioi out-in ActLoopNT-out 17.826 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.11, 133.17 APE9-dihe-in -138.51, 142.25 APE8-dihe-in -82.26, 68.13 APE8-rot-na 29.26 APE67-dihe-in -71.63, -9.4 -61.34, -31.95 APE12-dist-na 14.303 APE11-dist-na 10.211 APE10-dist-na 6.041 APE9-dist-in 7.145 None None None XRAY 2.6 0.203 0.232 A 317 293 1 0 0 1 [[1023, 1292]] 1.0 3eta Homo sapiens TYR_INSR_HUMAN TYR 1.6e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 3ETAB P06213 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.917 11.175 BBAminus -133.15, -176.66 -152.04, 106.96 -74.04, -41.1 283.79, 91.95 126.4, -175.96 in-in in 8.351 Saltbr-in 3.111 HRD-in -71.49, -47.77 78.43, -20.3 in-out-in SNCioi out-in ActLoopNT-out 17.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.8, 131.91 APE9-dihe-in -139.37, 136.91 APE8-dihe-in -77.51, 68.63 APE8-rot-na 28.59 APE67-dihe-in -74.17, -10.01 -54.55, -36.82 APE12-dist-na 14.326 APE11-dist-na 10.173 APE10-dist-na 5.896 APE9-dist-in 7.247 None None None XRAY 2.6 0.203 0.232 B 317 292 2 0 0 2 [[1023, 1292]] 1.0 3eta Homo sapiens TYR_INSR_HUMAN TYR 1.6e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR_HUMAN 8DWNA P06213 1014 1310 1382.0 No_ligand No_ligand Inactive None 999.0 999.0 None -95.48, -147.03 167.35, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.184 Saltbr-out 6.094 HRD-in -65.71, -54.25 86.56, -19.69 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.95, 141.67 APE9-dihe-in -121.95, 127.79 APE8-dihe-in -80.86, 78.35 APE8-rot-na 32.73 APE67-dihe-in -73.46, -9.67 -56.68, -44.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2 C1008S,Y1011F PTR1185,PTR1189 PTR1185,PTR1189 XRAY 2.15 0.195 0.247 A 306 286 11 0 0 11 [[1023, 1292]] 1.0 8dwn Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor

TYR_INSR (Insulin receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name