TYR_INSR (Insulin receptor)

Total number of chains: 26
Active chains: 7
Uniprot: INSR_HUMAN
Kinase Domain Residues: 1023 - 1292
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 38.5% AF-P06213-K1A
DFGin None 8 30.8% 5HHWA
DFGin ABAminus 4 15.4% 3BU6A
DFGout BBAminus 3 11.5% 1IRKA
None None 1 3.8% 8DWNA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
INSR 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.6591 13.9339 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.2612 Saltbr-in 3.1304 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.8444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.9367 APE11-dist-na 11.7238 APE10-dist-na 11.3004 APE9-dist-in 7.4014 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 3bu5 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.3572 13.4037 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.1751 Saltbr-in 2.4413 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.0293 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.7406 APE11-dist-na 10.5509 APE10-dist-na 11.0271 APE9-dist-in 6.6146 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328.0 310.0 0 30 30 0 [[1023, 1292]] 1.0 4xlv TYR_INSR_HUMAN TYR 1.7e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR AF-P06213-K1A P06213 1015 1300 1382.0 No_ligand No_ligand Active DFGin 6.4423 13.5827 BLAminus -131.7, -172.45 45.37, 86.41 -94.16, 16.44 302.88, 99.36 -59.84, -31.96 in-in in 8.2467 Saltbr-in 2.6737 HRD-in -73.51, -42.55 67.15, -19.42 in-in-in SNCiii in-in ActLoopNT-in 2.9665 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.18, 137.66 APE9-dihe-in -134.51, 139.18 APE8-dihe-in -78.44, 64.7 APE8-rot-na 35.42 APE67-dihe-in -75.31, -12.73 -45.13, -39.55 APE12-dist-na 15.053 APE11-dist-na 10.9693 APE10-dist-na 10.1027 APE9-dist-in 7.0405 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1023, 1292]] 1.0 AF-P06213-K1 TYR_INSR_HUMAN TYR 1.1e-96 329.0 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR AF-P06213-K3A P06213 1015 1300 1382.0 No_ligand No_ligand Active DFGin 5.9245 13.0713 BLAminus -130.69, -170.6 46.9, 83.67 -94.17, 11.86 307.8, 94.97 -60.63, -30.18 in-in in 8.0541 Saltbr-in 2.702 HRD-in -75.97, -44.42 67.04, -12.49 in-in-in SNCiii in-in ActLoopNT-in 2.9161 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.4, 144.11 APE9-dihe-in -144.36, 141.94 APE8-dihe-in -80.35, 60.58 APE8-rot-na 36.98 APE67-dihe-in -71.25, -11.2 -43.91, -40.1 APE12-dist-na 15.2124 APE11-dist-na 11.3383 APE10-dist-na 9.8636 APE9-dist-in 6.7768 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1023, 1292]] 1.0 AF-P06213-K3 TYR_INSR_HUMAN TYR 1.1e-96 329.0 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1GAGA P06213 1008 1310 1382.0 No_ligand No_ligand Active DFGin 6.4716 14.3547 BLAminus -139.79, -163.29 39.42, 88.74 -105.4, 34.47 300.89, 100.42 -68.02, -37.48 in-in in 8.2108 Saltbr-in 3.0518 HRD-in -70.91, -47.43 72.33, -9.91 in-in-in SNCiii in-in ActLoopNT-in 2.8081 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.0, 110.5 APE9-dihe-in -118.5, 144.45 APE8-dihe-in -78.32, 65.87 APE8-rot-na 35.19 APE67-dihe-in -59.72, -1.72 -33.26, -57.54 APE12-dist-na 15.007 APE11-dist-na 10.7529 APE10-dist-na 9.8952 APE9-dist-in 6.9259 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.7 0.214 0.269 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1gag TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1RQQA P06213 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.3041 13.6548 BLAminus -139.27, -172.16 50.78, 88.11 -102.35, 26.03 306.58, 94.08 -57.3, -43.84 in-in in 7.8446 Saltbr-in 2.7395 HRD-in -71.1, -43.22 70.05, -11.76 in-in-in SNCiii in-in ActLoopNT-in 2.9269 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.1, 113.79 APE9-dihe-in -119.85, 145.04 APE8-dihe-in -81.27, 63.72 APE8-rot-na 35.79 APE67-dihe-in -62.06, -15.17 -39.6, -48.57 APE12-dist-na 14.863 APE11-dist-na 10.6827 APE10-dist-na 9.7658 APE9-dist-in 6.8912 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 A 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 1rqq TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1RQQB P06213 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.4257 13.7866 BLAminus -137.51, -169.29 49.47, 88.05 -100.38, 24.24 303.21, 103.09 -57.34, -45.05 in-in in 7.8496 Saltbr-in 3.2513 HRD-in -70.29, -44.51 70.11, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.8, 112.61 APE9-dihe-in -120.76, 146.23 APE8-dihe-in -80.75, 64.53 APE8-rot-na 38.22 APE67-dihe-in -64.56, -12.7 -44.47, -42.91 APE12-dist-na 14.8782 APE11-dist-na 10.7174 APE10-dist-na 9.7472 APE9-dist-in 6.8619 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 B 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 1rqq TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 2AUHA P06213 1011 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.1405 13.65 ABAminus -136.58, -4.55 -122.41, 138.22 -136.1, 17.13 297.74, 110.36 -54.48, -33.89 in-in in 8.4039 Saltbr-in 2.705 HRD-in -71.8, -48.89 72.15, -21.21 in-in-in SNCiii in-in ActLoopNT-in 2.9571 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.66, 123.66 APE9-dihe-in -133.04, 151.36 APE8-dihe-in -70.19, 59.35 APE8-rot-na 32.97 APE67-dihe-in -65.61, -7.78 -36.89, -48.67 APE12-dist-na 15.4002 APE11-dist-na 11.1462 APE10-dist-na 9.8774 APE9-dist-in 6.7568 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.2 0.223 0.254 A 306.0 300.0 0 30 30 0 [[1023, 1292]] 1.0 2auh TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 2B4SB P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.4787 13.8198 ABAminus -125.78, 6.45 -136.21, 138.63 -137.01, 36.1 305.43, 85.48 -62.07, -22.25 in-in in 8.0452 Saltbr-in 3.5864 HRD-in -75.2, -47.87 71.7, -18.35 in-in-in SNCiii in-in ActLoopNT-in 2.7912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.64, 128.11 APE9-dihe-in -127.63, 149.14 APE8-dihe-in -79.25, 69.85 APE8-rot-na 37.38 APE67-dihe-in -66.83, -13.89 -42.23, -45.27 APE12-dist-na 15.0347 APE11-dist-na 11.2888 APE10-dist-na 10.9363 APE9-dist-in 7.457 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 B 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 2b4s TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 2B4SD P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.5924 14.0884 ABAminus -130.66, 15.42 -144.64, 123.77 -125.26, 40.8 306.28, 76.94 -64.15, -16.22 in-in in 7.9815 Saltbr-in 2.648 HRD-in -75.91, -45.41 68.78, -17.89 in-in-in SNCiii in-in ActLoopNT-in 2.8804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.77, 132.95 APE9-dihe-in -133.75, 151.9 APE8-dihe-in -79.94, 78.72 APE8-rot-na 36.75 APE67-dihe-in -73.63, -5.75 -50.54, -37.22 APE12-dist-na 14.815 APE11-dist-na 11.4645 APE10-dist-na 11.398 APE9-dist-in 7.4086 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 D 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 2b4s TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 3BU6A P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.9823 14.0035 ABAminus -127.49, -6.05 -146.78, 128.5 -126.39, 29.26 301.19, 85.56 -62.37, -9.3 in-in in 8.2511 Saltbr-in 3.5603 HRD-in -76.09, -48.83 72.52, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.8848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.83, 102.44 APE9-dihe-in -128.25, 150.85 APE8-dihe-in -77.03, 62.98 APE8-rot-na 32.44 APE67-dihe-in -72.83, -9.55 -48.55, -39.5 APE12-dist-na 16.1225 APE11-dist-na 12.0764 APE10-dist-na 11.7461 APE9-dist-in 7.7403 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.95 0.202 0.239 A 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 3bu6 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.1283 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.9234 Saltbr-out 4.3926 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.9018 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.5115 APE11-dist-na 10.4265 APE10-dist-na 9.7642 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1ir3 TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 3BU3A P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.8314 14.3175 BLAminus -125.34, -173.11 49.37, 91.34 -105.76, 28.79 293.31, 96.09 -61.52, -23.48 in-out in 8.3343 Saltbr-out 3.6427 HRD-in -77.13, -47.35 74.01, -9.17 out-in-in SNCoii in-in ActLoopNT-in 2.8876 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.87, 102.94 APE9-dihe-in -129.84, 150.89 APE8-dihe-in -79.69, 65.67 APE8-rot-na 33.39 APE67-dihe-in -69.85, -9.41 -51.56, -40.22 APE12-dist-na 15.8144 APE11-dist-na 11.5839 APE10-dist-na 11.082 APE9-dist-in 7.3699 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.65 0.203 0.22 A 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 3bu3 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 2Z8CA P06213 1011 1310 1382.0 S91:60001 Type1 Inactive DFGin 6.401 12.923 BLAminus -126.28, -180.0 45.53, 101.6 -113.26, 32.07 305.0, 102.45 -55.7, -35.78 in-out in 7.4783 Saltbr-out 3.6266 HRD-in -88.34, -29.28 53.1, 14.66 out-in-in SNCoii in-in ActLoopNT-in 2.8483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.92, 127.58 APE9-dihe-in -136.04, 148.74 APE8-dihe-in -92.61, 86.13 APE8-rot-na 40.99 APE67-dihe-in -57.55, -15.17 -59.74, -44.88 APE12-dist-na 14.522 APE11-dist-na 10.6018 APE10-dist-na 9.7643 APE9-dist-in 6.8834 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.25 0.217 0.292 A 303.0 300.0 0 30 30 0 [[1023, 1292]] 1.0 2z8c TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.6413 13.7197 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.8952 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6829 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306.0 282.0 16 30 14 16 [[1023, 1292]] 1.0 1i44 TYR_INSR_HUMAN TYR 3.4e-96 327.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1P14A P06213 1005 1310 1382.0 No_ligand No_ligand Inactive DFGin 7.6107 15.3442 None -93.61, -127.04 -78.93, 153.19 -166.81, 155.93 65.2, 94.97 -69.26, 999.0 in-out in 9.2508 Saltbr-out 5.4695 HRD-in -68.39, -55.7 74.95, -11.95 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.41 APE8-rot-na 37.98 APE67-dihe-in -68.35, -7.74 -43.78, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1008S,D1159N None None XRAY 1.9 0.225 0.24 A 306.0 287.0 19 30 11 19 [[1023, 1292]] 1.0 1p14 TYR_INSR_HUMAN TYR 5e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 4IBMA P06213 1009 1309 1382.0 IR1:61301 Type1 Inactive DFGin 5.6235 15.3135 None -76.0, 163.85 -44.82, 128.63 -69.67, 135.99 297.32, 165.57 60.17, 44.87 out-out out 10.6453 Saltbr-out 7.271 HRD-in -68.74, -46.51 75.22, -15.25 out-out-in SNCooi out-in ActLoopNT-out 15.6653 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 121.44 APE9-dihe-in -109.91, 120.82 APE8-dihe-in -81.27, 70.1 APE8-rot-na 28.73 APE67-dihe-in -71.57, -11.47 -57.01, -32.73 APE12-dist-na 18.7378 APE11-dist-na 15.2744 APE10-dist-na 11.5056 APE9-dist-in 7.3145 K1278N None None XRAY 1.8 0.184 0.218 A 306.0 301.0 0 30 30 0 [[1023, 1292]] 1.0 4ibm TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 4IBMB P06213 1014 1310 1382.0 IR1:61301 Type1 Inactive DFGin 6.943 16.4452 None -69.6, 155.55 -45.67, 125.47 -61.25, 129.45 282.72, 8.49 78.34, 8.83 in-out in 9.4175 Saltbr-out 5.034 HRD-in -66.87, -50.14 74.82, -11.33 out-out-in SNCooi out-in ActLoopNT-out 15.2219 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 122.58 APE9-dihe-in -120.44, 134.35 APE8-dihe-in -81.79, 69.08 APE8-rot-na 32.76 APE67-dihe-in -70.68, -10.48 -58.86, -32.74 APE12-dist-na 19.958 APE11-dist-na 16.3087 APE10-dist-na 12.6646 APE9-dist-in 7.3059 K1278N None None XRAY 1.8 0.184 0.218 B 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 4ibm TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 5E1SA P06213 1010 1310 1382.0 5JA:61301 Type1 Inactive DFGin 6.8652 15.0896 None -82.55, -126.51 -82.76, 146.74 -146.5, 173.12 61.91, 96.0 -67.13, 97.4 in-out in 8.8331 Saltbr-out 6.372 HRD-in -66.03, -52.34 70.18, -7.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -78.62, 65.27 APE8-rot-na 31.33 APE67-dihe-in -70.73, -11.27 -48.96, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3247 None None None XRAY 2.264 0.215 0.262 A 308.0 284.0 17 30 13 17 [[1023, 1292]] 1.0 5e1s TYR_INSR_HUMAN TYR 5.6e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 3EKKA P06213 1007 1309 1382.0 GS2:60001 Type1 Inactive DFGin 6.9318 15.2617 None -91.44, -126.11 -77.81, 134.04 -139.23, 999.0 58.35, 102.32 999.0, 999.0 in-out in 9.2869 Saltbr-out 5.3303 HRD-in -69.72, -54.17 78.3, -13.96 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -25.52 APE9-dihe-in -83.53, 136.03 APE8-dihe-in -85.94, 70.21 APE8-rot-na 27.34 APE67-dihe-in -74.98, -12.32 -58.97, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5248 C1008S,D1159N None None XRAY 2.1 0.207 0.26 A 307.0 285.0 18 30 12 18 [[1023, 1292]] 1.0 3ekk TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 3EKNA P06213 1011 1310 1382.0 GS3:60001 Type1 Inactive DFGin 6.2472 13.3535 None -59.53, -41.76 -156.68, -173.98 -81.39, 6.66 55.61, 95.58 69.22, 37.13 in-out in 8.4857 Saltbr-out 4.158 HRD-in -69.98, -55.95 75.05, -7.0 out-out-out SNCooo out-out ActLoopNT-out 9.4799 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.36, -23.41 APE9-dihe-in -94.03, 128.42 APE8-dihe-in -84.32, 117.17 APE8-rot-na 4.91 APE67-dihe-in -79.33, -4.28 -67.04, -22.99 APE12-dist-na 999.0 APE11-dist-na 13.7116 APE10-dist-na 9.2366 APE9-dist-in 4.8268 C1008S,D1159N None None XRAY 2.2 0.214 0.274 A 307.0 297.0 3 30 27 3 [[1023, 1292]] 1.0 3ekn TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.5467 15.218 None -93.96, -126.86 -75.33, 119.05 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.6442 Saltbr-out 6.2026 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.7099 APE11-dist-na 10.9449 APE10-dist-na 9.756 APE9-dist-in 7.5063 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307.0 306.0 0 30 30 0 [[1023, 1292]] 1.0 5hhw TYR_INSR_HUMAN TYR 5.5e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 1IRKA P06213 1008 1310 1382.0 No_ligand No_ligand Inactive DFGout 14.1104 8.254 BBAminus 170.32, 146.4 -160.79, 149.25 -78.89, -23.45 305.87, 140.64 112.61, 49.94 in-out in 9.3136 Saltbr-out 5.9629 HRD-in -57.78, -53.43 77.45, -13.51 out-out-in SNCooi out-in ActLoopNT-out 17.1823 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.89, 110.6 APE9-dihe-in -117.78, 141.32 APE8-dihe-in -78.03, 65.06 APE8-rot-na 33.68 APE67-dihe-in -72.48, -5.73 -49.44, -39.24 APE12-dist-na 19.1925 APE11-dist-na 15.0441 APE10-dist-na 10.8154 APE9-dist-in 7.4582 None None None XRAY 2.1 0.196 0.232 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1irk TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 3ETAA P06213 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.7961 11.0134 BBAminus -132.13, -174.21 -157.85, 103.42 -76.03, -16.02 293.96, 86.44 92.76, -168.27 in-in in 8.3215 Saltbr-in 2.7567 HRD-in -66.68, -47.32 76.44, -15.87 in-out-in SNCioi out-in ActLoopNT-out 17.8262 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.11, 133.17 APE9-dihe-in -138.51, 142.25 APE8-dihe-in -82.26, 68.13 APE8-rot-na 29.26 APE67-dihe-in -71.63, -9.4 -61.34, -31.95 APE12-dist-na 14.3031 APE11-dist-na 10.2115 APE10-dist-na 6.0412 APE9-dist-in 7.1449 None None None XRAY 2.6 0.203 0.232 A 317.0 293.0 1 30 29 1 [[1023, 1292]] 1.0 3eta TYR_INSR_HUMAN TYR 1.6e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 3ETAB P06213 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.9171 11.1754 BBAminus -133.15, -176.66 -152.04, 106.96 -74.04, -41.1 283.79, 91.95 126.4, -175.96 in-in in 8.351 Saltbr-in 3.1113 HRD-in -71.49, -47.77 78.43, -20.3 in-out-in SNCioi out-in ActLoopNT-out 17.8821 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.8, 131.91 APE9-dihe-in -139.37, 136.91 APE8-dihe-in -77.51, 68.63 APE8-rot-na 28.59 APE67-dihe-in -74.17, -10.01 -54.55, -36.82 APE12-dist-na 14.3265 APE11-dist-na 10.1734 APE10-dist-na 5.8956 APE9-dist-in 7.247 None None None XRAY 2.6 0.203 0.232 B 317.0 292.0 2 30 28 2 [[1023, 1292]] 1.0 3eta TYR_INSR_HUMAN TYR 1.6e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR 8DWNA P06213 1014 1310 1382.0 No_ligand No_ligand Inactive None 999.0 999.0 None -95.48, -147.03 167.35, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.1838 Saltbr-out 6.0939 HRD-in -65.71, -54.25 86.56, -19.69 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.95, 141.67 APE9-dihe-in -121.95, 127.79 APE8-dihe-in -80.86, 78.35 APE8-rot-na 32.73 APE67-dihe-in -73.46, -9.67 -56.68, -44.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2005 C1008S,Y1011F PTR1185,PTR1189 PTR1185,PTR1189 XRAY 2.15 0.195 0.247 A 306.0 286.0 11 30 19 11 [[1023, 1292]] 1.0 8dwn TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor

TYR_INSR (Insulin receptor)

Total number of chains: 26
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 38.5% AF-P06213-K1A
DFGin None 8 30.8% 5HHWA
DFGin ABAminus 4 15.4% 3BU6A
DFGout BBAminus 3 11.5% 1IRKA
None None 1 3.8% 8DWNA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
INSR INSR_HUMAN 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.6591 13.9339 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.2612 Saltbr-in 3.1304 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.8444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.9367 APE11-dist-na 11.7238 APE10-dist-na 11.3004 APE9-dist-in 7.4014 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 3bu5 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.3572 13.4037 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.1751 Saltbr-in 2.4413 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.0293 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.7406 APE11-dist-na 10.5509 APE10-dist-na 11.0271 APE9-dist-in 6.6146 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328.0 310.0 0 30 30 0 [[1023, 1292]] 1.0 4xlv Homo sapiens TYR_INSR_HUMAN TYR 1.7e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN AF-P06213-K1A P06213 1015 1300 1382.0 No_ligand No_ligand Active DFGin 6.4423 13.5827 BLAminus -131.7, -172.45 45.37, 86.41 -94.16, 16.44 302.88, 99.36 -59.84, -31.96 in-in in 8.2467 Saltbr-in 2.6737 HRD-in -73.51, -42.55 67.15, -19.42 in-in-in SNCiii in-in ActLoopNT-in 2.9665 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.18, 137.66 APE9-dihe-in -134.51, 139.18 APE8-dihe-in -78.44, 64.7 APE8-rot-na 35.42 APE67-dihe-in -75.31, -12.73 -45.13, -39.55 APE12-dist-na 15.053 APE11-dist-na 10.9693 APE10-dist-na 10.1027 APE9-dist-in 7.0405 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1023, 1292]] 1.0 AF-P06213-K1 Homo sapiens TYR_INSR_HUMAN TYR 1.1e-96 329.0 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN AF-P06213-K3A P06213 1015 1300 1382.0 No_ligand No_ligand Active DFGin 5.9245 13.0713 BLAminus -130.69, -170.6 46.9, 83.67 -94.17, 11.86 307.8, 94.97 -60.63, -30.18 in-in in 8.0541 Saltbr-in 2.702 HRD-in -75.97, -44.42 67.04, -12.49 in-in-in SNCiii in-in ActLoopNT-in 2.9161 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.4, 144.11 APE9-dihe-in -144.36, 141.94 APE8-dihe-in -80.35, 60.58 APE8-rot-na 36.98 APE67-dihe-in -71.25, -11.2 -43.91, -40.1 APE12-dist-na 15.2124 APE11-dist-na 11.3383 APE10-dist-na 9.8636 APE9-dist-in 6.7768 None None None AF2 -1.0 1.0 1.0 A 286.0 286.0 0 30 30 0 [[1023, 1292]] 1.0 AF-P06213-K3 Homo sapiens TYR_INSR_HUMAN TYR 1.1e-96 329.0 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1GAGA P06213 1008 1310 1382.0 No_ligand No_ligand Active DFGin 6.4716 14.3547 BLAminus -139.79, -163.29 39.42, 88.74 -105.4, 34.47 300.89, 100.42 -68.02, -37.48 in-in in 8.2108 Saltbr-in 3.0518 HRD-in -70.91, -47.43 72.33, -9.91 in-in-in SNCiii in-in ActLoopNT-in 2.8081 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.0, 110.5 APE9-dihe-in -118.5, 144.45 APE8-dihe-in -78.32, 65.87 APE8-rot-na 35.19 APE67-dihe-in -59.72, -1.72 -33.26, -57.54 APE12-dist-na 15.007 APE11-dist-na 10.7529 APE10-dist-na 9.8952 APE9-dist-in 6.9259 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.7 0.214 0.269 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1gag Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1RQQA P06213 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.3041 13.6548 BLAminus -139.27, -172.16 50.78, 88.11 -102.35, 26.03 306.58, 94.08 -57.3, -43.84 in-in in 7.8446 Saltbr-in 2.7395 HRD-in -71.1, -43.22 70.05, -11.76 in-in-in SNCiii in-in ActLoopNT-in 2.9269 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.1, 113.79 APE9-dihe-in -119.85, 145.04 APE8-dihe-in -81.27, 63.72 APE8-rot-na 35.79 APE67-dihe-in -62.06, -15.17 -39.6, -48.57 APE12-dist-na 14.863 APE11-dist-na 10.6827 APE10-dist-na 9.7658 APE9-dist-in 6.8912 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 A 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 1rqq Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1RQQB P06213 1014 1310 1382.0 No_ligand No_ligand Active DFGin 6.4257 13.7866 BLAminus -137.51, -169.29 49.47, 88.05 -100.38, 24.24 303.21, 103.09 -57.34, -45.05 in-in in 7.8496 Saltbr-in 3.2513 HRD-in -70.29, -44.51 70.11, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.8, 112.61 APE9-dihe-in -120.76, 146.23 APE8-dihe-in -80.75, 64.53 APE8-rot-na 38.22 APE67-dihe-in -64.56, -12.7 -44.47, -42.91 APE12-dist-na 14.8782 APE11-dist-na 10.7174 APE10-dist-na 9.7472 APE9-dist-in 6.8619 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.6 0.229 0.277 B 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 1rqq Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 2AUHA P06213 1011 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.1405 13.65 ABAminus -136.58, -4.55 -122.41, 138.22 -136.1, 17.13 297.74, 110.36 -54.48, -33.89 in-in in 8.4039 Saltbr-in 2.705 HRD-in -71.8, -48.89 72.15, -21.21 in-in-in SNCiii in-in ActLoopNT-in 2.9571 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.66, 123.66 APE9-dihe-in -133.04, 151.36 APE8-dihe-in -70.19, 59.35 APE8-rot-na 32.97 APE67-dihe-in -65.61, -7.78 -36.89, -48.67 APE12-dist-na 15.4002 APE11-dist-na 11.1462 APE10-dist-na 9.8774 APE9-dist-in 6.7568 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.2 0.223 0.254 A 306.0 300.0 0 30 30 0 [[1023, 1292]] 1.0 2auh Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 2B4SB P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.4787 13.8198 ABAminus -125.78, 6.45 -136.21, 138.63 -137.01, 36.1 305.43, 85.48 -62.07, -22.25 in-in in 8.0452 Saltbr-in 3.5864 HRD-in -75.2, -47.87 71.7, -18.35 in-in-in SNCiii in-in ActLoopNT-in 2.7912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.64, 128.11 APE9-dihe-in -127.63, 149.14 APE8-dihe-in -79.25, 69.85 APE8-rot-na 37.38 APE67-dihe-in -66.83, -13.89 -42.23, -45.27 APE12-dist-na 15.0347 APE11-dist-na 11.2888 APE10-dist-na 10.9363 APE9-dist-in 7.457 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 B 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 2b4s Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 2B4SD P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.5924 14.0884 ABAminus -130.66, 15.42 -144.64, 123.77 -125.26, 40.8 306.28, 76.94 -64.15, -16.22 in-in in 7.9815 Saltbr-in 2.648 HRD-in -75.91, -45.41 68.78, -17.89 in-in-in SNCiii in-in ActLoopNT-in 2.8804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.77, 132.95 APE9-dihe-in -133.75, 151.9 APE8-dihe-in -79.94, 78.72 APE8-rot-na 36.75 APE67-dihe-in -73.63, -5.75 -50.54, -37.22 APE12-dist-na 14.815 APE11-dist-na 11.4645 APE10-dist-na 11.398 APE9-dist-in 7.4086 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.3 0.208 0.239 D 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 2b4s Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 3BU6A P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.9823 14.0035 ABAminus -127.49, -6.05 -146.78, 128.5 -126.39, 29.26 301.19, 85.56 -62.37, -9.3 in-in in 8.2511 Saltbr-in 3.5603 HRD-in -76.09, -48.83 72.52, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.8848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.83, 102.44 APE9-dihe-in -128.25, 150.85 APE8-dihe-in -77.03, 62.98 APE8-rot-na 32.44 APE67-dihe-in -72.83, -9.55 -48.55, -39.5 APE12-dist-na 16.1225 APE11-dist-na 12.0764 APE10-dist-na 11.7461 APE9-dist-in 7.7403 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.95 0.202 0.239 A 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 3bu6 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.1283 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.9234 Saltbr-out 4.3926 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.9018 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.5115 APE11-dist-na 10.4265 APE10-dist-na 9.7642 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1ir3 Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 3BU3A P06213 1014 1310 1382.0 No_ligand No_ligand Inactive DFGin 6.8314 14.3175 BLAminus -125.34, -173.11 49.37, 91.34 -105.76, 28.79 293.31, 96.09 -61.52, -23.48 in-out in 8.3343 Saltbr-out 3.6427 HRD-in -77.13, -47.35 74.01, -9.17 out-in-in SNCoii in-in ActLoopNT-in 2.8876 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.87, 102.94 APE9-dihe-in -129.84, 150.89 APE8-dihe-in -79.69, 65.67 APE8-rot-na 33.39 APE67-dihe-in -69.85, -9.41 -51.56, -40.22 APE12-dist-na 15.8144 APE11-dist-na 11.5839 APE10-dist-na 11.082 APE9-dist-in 7.3699 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.65 0.203 0.22 A 306.0 297.0 0 30 30 0 [[1023, 1292]] 1.0 3bu3 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 2Z8CA P06213 1011 1310 1382.0 S91:60001 Type1 Inactive DFGin 6.401 12.923 BLAminus -126.28, -180.0 45.53, 101.6 -113.26, 32.07 305.0, 102.45 -55.7, -35.78 in-out in 7.4783 Saltbr-out 3.6266 HRD-in -88.34, -29.28 53.1, 14.66 out-in-in SNCoii in-in ActLoopNT-in 2.8483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.92, 127.58 APE9-dihe-in -136.04, 148.74 APE8-dihe-in -92.61, 86.13 APE8-rot-na 40.99 APE67-dihe-in -57.55, -15.17 -59.74, -44.88 APE12-dist-na 14.522 APE11-dist-na 10.6018 APE10-dist-na 9.7643 APE9-dist-in 6.8834 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 3.25 0.217 0.292 A 303.0 300.0 0 30 30 0 [[1023, 1292]] 1.0 2z8c Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.6413 13.7197 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.8952 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6829 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306.0 282.0 16 30 14 16 [[1023, 1292]] 1.0 1i44 Homo sapiens TYR_INSR_HUMAN TYR 3.4e-96 327.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1P14A P06213 1005 1310 1382.0 No_ligand No_ligand Inactive DFGin 7.6107 15.3442 None -93.61, -127.04 -78.93, 153.19 -166.81, 155.93 65.2, 94.97 -69.26, 999.0 in-out in 9.2508 Saltbr-out 5.4695 HRD-in -68.39, -55.7 74.95, -11.95 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.41 APE8-rot-na 37.98 APE67-dihe-in -68.35, -7.74 -43.78, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1008S,D1159N None None XRAY 1.9 0.225 0.24 A 306.0 287.0 19 30 11 19 [[1023, 1292]] 1.0 1p14 Homo sapiens TYR_INSR_HUMAN TYR 5e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 4IBMA P06213 1009 1309 1382.0 IR1:61301 Type1 Inactive DFGin 5.6235 15.3135 None -76.0, 163.85 -44.82, 128.63 -69.67, 135.99 297.32, 165.57 60.17, 44.87 out-out out 10.6453 Saltbr-out 7.271 HRD-in -68.74, -46.51 75.22, -15.25 out-out-in SNCooi out-in ActLoopNT-out 15.6653 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.2, 121.44 APE9-dihe-in -109.91, 120.82 APE8-dihe-in -81.27, 70.1 APE8-rot-na 28.73 APE67-dihe-in -71.57, -11.47 -57.01, -32.73 APE12-dist-na 18.7378 APE11-dist-na 15.2744 APE10-dist-na 11.5056 APE9-dist-in 7.3145 K1278N None None XRAY 1.8 0.184 0.218 A 306.0 301.0 0 30 30 0 [[1023, 1292]] 1.0 4ibm Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 4IBMB P06213 1014 1310 1382.0 IR1:61301 Type1 Inactive DFGin 6.943 16.4452 None -69.6, 155.55 -45.67, 125.47 -61.25, 129.45 282.72, 8.49 78.34, 8.83 in-out in 9.4175 Saltbr-out 5.034 HRD-in -66.87, -50.14 74.82, -11.33 out-out-in SNCooi out-in ActLoopNT-out 15.2219 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.04, 122.58 APE9-dihe-in -120.44, 134.35 APE8-dihe-in -81.79, 69.08 APE8-rot-na 32.76 APE67-dihe-in -70.68, -10.48 -58.86, -32.74 APE12-dist-na 19.958 APE11-dist-na 16.3087 APE10-dist-na 12.6646 APE9-dist-in 7.3059 K1278N None None XRAY 1.8 0.184 0.218 B 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 4ibm Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 5E1SA P06213 1010 1310 1382.0 5JA:61301 Type1 Inactive DFGin 6.8652 15.0896 None -82.55, -126.51 -82.76, 146.74 -146.5, 173.12 61.91, 96.0 -67.13, 97.4 in-out in 8.8331 Saltbr-out 6.372 HRD-in -66.03, -52.34 70.18, -7.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -78.62, 65.27 APE8-rot-na 31.33 APE67-dihe-in -70.73, -11.27 -48.96, -36.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3247 None None None XRAY 2.264 0.215 0.262 A 308.0 284.0 17 30 13 17 [[1023, 1292]] 1.0 5e1s Homo sapiens TYR_INSR_HUMAN TYR 5.6e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 3EKKA P06213 1007 1309 1382.0 GS2:60001 Type1 Inactive DFGin 6.9318 15.2617 None -91.44, -126.11 -77.81, 134.04 -139.23, 999.0 58.35, 102.32 999.0, 999.0 in-out in 9.2869 Saltbr-out 5.3303 HRD-in -69.72, -54.17 78.3, -13.96 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -25.52 APE9-dihe-in -83.53, 136.03 APE8-dihe-in -85.94, 70.21 APE8-rot-na 27.34 APE67-dihe-in -74.98, -12.32 -58.97, -28.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5248 C1008S,D1159N None None XRAY 2.1 0.207 0.26 A 307.0 285.0 18 30 12 18 [[1023, 1292]] 1.0 3ekk Homo sapiens TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 3EKNA P06213 1011 1310 1382.0 GS3:60001 Type1 Inactive DFGin 6.2472 13.3535 None -59.53, -41.76 -156.68, -173.98 -81.39, 6.66 55.61, 95.58 69.22, 37.13 in-out in 8.4857 Saltbr-out 4.158 HRD-in -69.98, -55.95 75.05, -7.0 out-out-out SNCooo out-out ActLoopNT-out 9.4799 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.36, -23.41 APE9-dihe-in -94.03, 128.42 APE8-dihe-in -84.32, 117.17 APE8-rot-na 4.91 APE67-dihe-in -79.33, -4.28 -67.04, -22.99 APE12-dist-na 999.0 APE11-dist-na 13.7116 APE10-dist-na 9.2366 APE9-dist-in 4.8268 C1008S,D1159N None None XRAY 2.2 0.214 0.274 A 307.0 297.0 3 30 27 3 [[1023, 1292]] 1.0 3ekn Homo sapiens TYR_INSR_HUMAN TYR 5.1e-96 326.9 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.5467 15.218 None -93.96, -126.86 -75.33, 119.05 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.6442 Saltbr-out 6.2026 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.7099 APE11-dist-na 10.9449 APE10-dist-na 9.756 APE9-dist-in 7.5063 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307.0 306.0 0 30 30 0 [[1023, 1292]] 1.0 5hhw Homo sapiens TYR_INSR_HUMAN TYR 5.5e-96 326.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 1IRKA P06213 1008 1310 1382.0 No_ligand No_ligand Inactive DFGout 14.1104 8.254 BBAminus 170.32, 146.4 -160.79, 149.25 -78.89, -23.45 305.87, 140.64 112.61, 49.94 in-out in 9.3136 Saltbr-out 5.9629 HRD-in -57.78, -53.43 77.45, -13.51 out-out-in SNCooi out-in ActLoopNT-out 17.1823 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.89, 110.6 APE9-dihe-in -117.78, 141.32 APE8-dihe-in -78.03, 65.06 APE8-rot-na 33.68 APE67-dihe-in -72.48, -5.73 -49.44, -39.24 APE12-dist-na 19.1925 APE11-dist-na 15.0441 APE10-dist-na 10.8154 APE9-dist-in 7.4582 None None None XRAY 2.1 0.196 0.232 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1irk Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 3ETAA P06213 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.7961 11.0134 BBAminus -132.13, -174.21 -157.85, 103.42 -76.03, -16.02 293.96, 86.44 92.76, -168.27 in-in in 8.3215 Saltbr-in 2.7567 HRD-in -66.68, -47.32 76.44, -15.87 in-out-in SNCioi out-in ActLoopNT-out 17.8262 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.11, 133.17 APE9-dihe-in -138.51, 142.25 APE8-dihe-in -82.26, 68.13 APE8-rot-na 29.26 APE67-dihe-in -71.63, -9.4 -61.34, -31.95 APE12-dist-na 14.3031 APE11-dist-na 10.2115 APE10-dist-na 6.0412 APE9-dist-in 7.1449 None None None XRAY 2.6 0.203 0.232 A 317.0 293.0 1 30 29 1 [[1023, 1292]] 1.0 3eta Homo sapiens TYR_INSR_HUMAN TYR 1.6e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 3ETAB P06213 1017 1310 1382.0 351:62001 Type2 Inactive DFGout 15.9171 11.1754 BBAminus -133.15, -176.66 -152.04, 106.96 -74.04, -41.1 283.79, 91.95 126.4, -175.96 in-in in 8.351 Saltbr-in 3.1113 HRD-in -71.49, -47.77 78.43, -20.3 in-out-in SNCioi out-in ActLoopNT-out 17.8821 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.8, 131.91 APE9-dihe-in -139.37, 136.91 APE8-dihe-in -77.51, 68.63 APE8-rot-na 28.59 APE67-dihe-in -74.17, -10.01 -54.55, -36.82 APE12-dist-na 14.3265 APE11-dist-na 10.1734 APE10-dist-na 5.8956 APE9-dist-in 7.247 None None None XRAY 2.6 0.203 0.232 B 317.0 292.0 2 30 28 2 [[1023, 1292]] 1.0 3eta Homo sapiens TYR_INSR_HUMAN TYR 1.6e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
INSR INSR_HUMAN 8DWNA P06213 1014 1310 1382.0 No_ligand No_ligand Inactive None 999.0 999.0 None -95.48, -147.03 167.35, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.1838 Saltbr-out 6.0939 HRD-in -65.71, -54.25 86.56, -19.69 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.95, 141.67 APE9-dihe-in -121.95, 127.79 APE8-dihe-in -80.86, 78.35 APE8-rot-na 32.73 APE67-dihe-in -73.46, -9.67 -56.68, -44.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2005 C1008S,Y1011F PTR1185,PTR1189 PTR1185,PTR1189 XRAY 2.15 0.195 0.247 A 306.0 286.0 11 30 19 11 [[1023, 1292]] 1.0 8dwn Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor

TYR_INSR (Insulin receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name