Ligand: 453

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein

Ligand: 453

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 4WNKA
DFGin BLAminus 1 50.0% 5HE0A

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC GRK2 ARBK1_BOVIN 5HE0A 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK5 GRK5_BOVIN 4WNKA 2.42 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1.5_Front 24 - 541 0 None None G protein-coupled receptor kinase 5 Bos taurus

Ligand: 453

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 4WNKA
DFGin BLAminus 1 50.0% 5HE0A

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC GRK2 ARBK1_BOVIN 5HE0A 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK5 GRK5_BOVIN 4WNKA 2.42 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1.5_Front 24 - 541 0 None None G protein-coupled receptor kinase 5 Bos taurus