AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 25
Active chains: 15
Family: AGC
Uniprot: GRK5_HUMAN
Kinase Domain Residues: 186 - 448
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 64.0% AF-P34947-K1A
DFGin None 5 20.0% 6PJXA
DFGin ABAminus 4 16.0% 9BRKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
4TNDA 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.172 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.193 Saltbr-in 3.053 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.302 APE11-dist-in 12.056 APE10-dist-in 6.23 APE9-dist-in 4.255 None None None XRAY 1.802 0.174 0.205 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnd AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9CKRA 25 542 590.0 ATP:603 ATPlike Active DFGin 6.172 12.867 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.589 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.872 APE11-dist-in 12.258 APE10-dist-in 6.529 APE9-dist-in 4.181 D311N None None XRAY 2.8 0.239 0.286 A 598 501 0 0 0 0 [[186, 448]] 1.0 9ckr AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9CKSA 25 542 590.0 ATP:603 ATPlike Active DFGin 6.038 13.061 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.222 Saltbr-in 2.672 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.616 APE11-dist-in 12.407 APE10-dist-in 6.563 APE9-dist-in 4.207 D311N None None XRAY 3.08 0.228 0.28 A 598 501 0 0 0 0 [[186, 448]] 1.0 9cks AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AF-P34947-K1A 178 456 590.0 No_ligand No_ligand Active DFGin 5.488 12.674 BLAminus -115.97, -177.38 48.25, 67.07 -77.66, 16.16 284.97, 107.27 -63.58, -32.29 in-in in 8.966 Saltbr-in 2.674 HRD-in -81.4, -44.95 66.95, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 159.3 APE9-dihe-na 118.39, -174.52 APE8-dihe-in -94.59, 137.57 APE8-rot-in 303.09 APE67-dihe-inflip 95.72, -15.07 -56.34, 127.54 APE12-dist-in 10.505 APE11-dist-in 12.248 APE10-dist-in 6.215 APE9-dist-in 3.781 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K1 AGC_GRK5_HUMAN AGC 6e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AF-P34947-K3A 178 456 590.0 No_ligand No_ligand Active DFGin 6.022 12.099 BLAminus -130.04, 178.69 50.56, 62.08 -71.61, 20.06 306.44, 6.94 -60.07, -35.44 in-in in 8.543 Saltbr-in 2.615 HRD-in -88.42, -48.64 68.04, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.09, 156.11 APE9-dihe-na 120.9, -174.14 APE8-dihe-in -94.05, 138.77 APE8-rot-in 297.52 APE67-dihe-inflip 92.74, -12.69 -58.9, 127.55 APE12-dist-in 10.541 APE11-dist-in 11.976 APE10-dist-in 5.961 APE9-dist-in 3.312 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K3 AGC_GRK5_HUMAN AGC 6e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9CKQA 25 542 590.0 No_ligand No_ligand Active DFGin 6.036 12.85 BLAminus -128.35, 170.36 62.76, 74.57 -90.62, 17.1 285.99, 91.78 -58.04, -33.82 in-in in 9.106 Saltbr-in 2.933 HRD-in -93.54, -52.56 67.97, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.01, 171.06 APE9-dihe-na 118.15, -151.5 APE8-dihe-in -127.65, 146.62 APE8-rot-in 290.59 APE67-dihe-inflip 92.51, -30.74 -57.11, 135.04 APE12-dist-in 9.779 APE11-dist-in 12.023 APE10-dist-in 6.163 APE9-dist-in 4.116 D311N None None XRAY 2.7 0.239 0.294 A 597 490 11 0 0 0 [[186, 448]] 1.0 9ckq AGC_GRK5_HUMAN AGC 7.5e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
4TNBA 15 543 590.0 SGV:601 Type1 Active DFGin 5.135 12.74 BLAminus -123.5, 176.17 54.54, 74.38 -84.69, 6.5 286.26, 112.63 -51.75, -34.18 in-in in 9.001 Saltbr-in 2.528 HRD-in -77.08, -45.38 66.65, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 150.87 APE9-dihe-na 143.24, -163.75 APE8-dihe-in -110.5, 150.66 APE8-rot-in 315.23 APE67-dihe-inflip 90.86, -23.2 -67.3, 136.98 APE12-dist-in 10.739 APE11-dist-in 11.875 APE10-dist-in 5.946 APE9-dist-in 4.112 None None None XRAY 2.113 0.175 0.232 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnb AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
8UAPA 25 542 590.0 W2T:601 Type1 Active DFGin 5.952 12.669 BLAminus -132.18, -179.7 52.11, 79.03 -91.08, 7.0 281.21, 78.18 -55.19, -15.59 in-in in 8.933 Saltbr-in 2.319 HRD-in -89.52, -55.99 69.41, 4.8 in-in-in SNCiii in-in ActLoopNT-in 3.075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 157.14 APE9-dihe-na 134.87, -160.65 APE8-dihe-in -105.62, 143.33 APE8-rot-in 315.67 APE67-dihe-inflip 91.84, -13.85 -56.42, 130.69 APE12-dist-in 10.242 APE11-dist-in 12.329 APE10-dist-in 6.498 APE9-dist-in 4.083 D311N None None XRAY 2.5 0.229 0.267 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uap AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BREA 25 542 590.0 W3F:601 Type1 Active DFGin 6.176 12.564 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.801 Saltbr-in 2.458 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.943 APE11-dist-in 12.131 APE10-dist-in 6.337 APE9-dist-in 4.122 D311N None None XRAY 2.8 0.215 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bre AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRGA 25 542 590.0 A1AQ6:601 Type1 Active DFGin 5.888 12.744 BLAminus -127.15, 171.02 61.76, 75.85 -94.14, 20.1 287.82, 78.85 -68.02, -19.4 in-in in 9.043 Saltbr-in 2.346 HRD-in -85.19, -53.81 70.34, 12.77 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 160.56 APE9-dihe-na 125.86, -158.84 APE8-dihe-in -113.45, 141.13 APE8-rot-in 318.14 APE67-dihe-inflip 91.69, -20.41 -53.6, 133.88 APE12-dist-in 9.77 APE11-dist-in 12.073 APE10-dist-in 6.219 APE9-dist-in 4.083 D311N None None XRAY 2.7 0.242 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brg AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRHA 25 542 590.0 A1AQ7:601 Type1 Active DFGin 6.213 12.998 BLAminus -137.89, -178.33 53.87, 65.42 -85.04, 16.09 287.04, 75.14 -57.93, -30.07 in-in in 9.364 Saltbr-in 2.788 HRD-in -82.45, -56.04 70.11, 8.28 in-in-in SNCiii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.58, 168.01 APE9-dihe-na 127.33, -166.12 APE8-dihe-in -113.88, 147.37 APE8-rot-in 307.37 APE67-dihe-inflip 89.75, -29.49 -53.29, 136.77 APE12-dist-in 10.364 APE11-dist-in 12.068 APE10-dist-in 6.136 APE9-dist-in 4.119 D311N None None XRAY 3.69 0.2 0.244 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brh AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRMA 25 542 590.0 A1ARC:601 Type1 Active DFGin 5.93 12.32 BLAminus -129.54, 170.53 64.08, 75.97 -94.87, 21.89 289.68, 68.45 -68.62, -20.59 in-in in 8.627 Saltbr-in 2.58 HRD-in -82.68, -56.6 72.77, 4.07 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 165.33 APE9-dihe-na 123.74, -150.01 APE8-dihe-in -120.92, 138.81 APE8-rot-in 302.36 APE67-dihe-inflip 99.67, -19.1 -52.94, 128.15 APE12-dist-in 9.803 APE11-dist-in 12.059 APE10-dist-in 6.213 APE9-dist-in 4.157 D311N None None XRAY 2.73 0.234 0.278 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brm AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRNA 25 542 590.0 A1ARD:601 Type1 Active DFGin 5.902 12.725 BLAminus -139.33, 159.94 74.16, 72.44 -89.41, 22.16 291.23, 67.98 -67.08, -25.78 in-in in 8.993 Saltbr-in 2.439 HRD-in -78.87, -49.6 65.54, 8.73 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.44, 151.94 APE9-dihe-na 136.85, -155.43 APE8-dihe-in -118.42, 144.51 APE8-rot-in 301.29 APE67-dihe-inflip 92.21, -11.38 -55.67, 128.36 APE12-dist-in 9.809 APE11-dist-in 11.996 APE10-dist-in 6.094 APE9-dist-in 4.274 D311N None None XRAY 2.9 0.209 0.256 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brn AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BROA 25 542 590.0 A1ARE:601 Type1 Active DFGin 5.964 12.572 BLAminus -128.27, -178.6 50.36, 73.78 -90.4, 21.64 280.73, 75.17 -69.22, -25.34 in-in in 8.906 Saltbr-in 2.39 HRD-in -93.36, -59.82 68.46, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.17, 167.74 APE9-dihe-na 123.28, -154.67 APE8-dihe-in -122.1, 138.71 APE8-rot-in 314.65 APE67-dihe-inflip 102.22, -12.34 -51.46, 123.36 APE12-dist-in 10.277 APE11-dist-in 12.337 APE10-dist-in 6.406 APE9-dist-in 4.05 D311N None None XRAY 2.8 0.221 0.271 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bro AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9CKPA 1 542 590.0 SGV:602 Type1 Active DFGin 5.386 11.98 BLAminus -132.87, 164.94 63.45, 71.08 -85.64, 18.91 320.14, 3.39 -67.22, -15.79 in-in in 8.975 Saltbr-in 3.569 HRD-in -105.81, -54.45 67.93, 0.86 in-in-in SNCiii in-in ActLoopNT-in 3.27 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.75, 161.15 APE9-dihe-na 132.47, 178.17 APE8-dihe-in -105.33, 153.16 APE8-rot-in 325.98 APE67-dihe-inflip 78.63, 4.41 -62.29, 127.28 APE12-dist-in 10.034 APE11-dist-in 12.223 APE10-dist-in 6.349 APE9-dist-in 4.192 D311N None None XRAY 2.6 0.236 0.27 A 598 538 0 0 0 0 [[186, 448]] 1.0 9ckp AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9CKOA 1 542 590.0 SGV:602 Type1 Inactive DFGin 5.808 12.496 ABAminus -119.73, -59.76 -93.86, 94.44 -93.46, 16.21 299.92, 79.42 -62.04, -34.62 in-in in 8.425 Saltbr-in 2.521 HRD-in -104.67, -57.7 74.0, 4.5 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 140.14 APE9-dihe-na 146.41, -176.34 APE8-dihe-in -106.42, 130.54 APE8-rot-in 306.78 APE67-dihe-inflip 81.24, -12.9 -51.64, 146.1 APE12-dist-in 10.452 APE11-dist-in 12.118 APE10-dist-in 6.155 APE9-dist-in 3.717 None None None XRAY 2.8 0.243 0.28 A 598 540 0 0 0 0 [[186, 448]] 1.0 9cko AGC_GRK5_HUMAN AGC 5.9e-84 287.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRKA 25 542 590.0 A1ARA:601 Type1 Inactive DFGin 5.999 12.725 ABAminus -113.29, -59.28 -86.52, 97.64 -98.22, 23.89 284.55, 73.36 -66.95, -28.05 in-in in 8.886 Saltbr-in 2.356 HRD-in -84.62, -58.9 74.96, -0.86 in-in-in SNCiii in-in ActLoopNT-in 3.06 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.94, 168.36 APE9-dihe-na 122.17, -155.18 APE8-dihe-in -114.33, 143.85 APE8-rot-in 306.85 APE67-dihe-inflip 94.43, -16.31 -58.15, 132.79 APE12-dist-in 9.666 APE11-dist-in 11.73 APE10-dist-in 6.061 APE9-dist-in 4.128 D311N None None XRAY 2.7 0.223 0.276 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brk AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRLA 25 542 590.0 A1ARB:601 Type1 Inactive DFGin 5.691 12.023 ABAminus -103.25, -52.89 -74.4, 160.18 -158.5, 11.72 277.51, 97.57 -69.39, -26.51 in-in in 8.836 Saltbr-in 2.354 HRD-in -84.95, -56.21 70.99, 10.31 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 162.58 APE9-dihe-na 130.63, -156.95 APE8-dihe-in -113.5, 144.35 APE8-rot-in 307.43 APE67-dihe-inflip 83.43, -12.88 -53.97, 135.79 APE12-dist-in 9.714 APE11-dist-in 11.875 APE10-dist-in 6.043 APE9-dist-in 4.223 D311N None None XRAY 2.73 0.231 0.275 A 598 501 0 0 0 0 [[186, 448]] 1.0 9brl AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRPA 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.253 12.479 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.91 Saltbr-in 3.037 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.932 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brp AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9MX2A 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.528 11.483 BLAminus -134.92, 166.93 57.12, 70.75 -87.84, 20.9 322.36, 5.46 -68.95, -14.98 in-out in 8.353 Saltbr-out 3.626 HRD-in -110.96, -57.41 68.72, 2.93 out-in-in SNCoii in-in ActLoopNT-in 3.364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.2, 161.4 APE9-dihe-na 129.58, 177.82 APE8-dihe-in -100.27, 150.38 APE8-rot-in 311.4 APE67-dihe-inflip 86.26, -1.66 -66.59, 129.67 APE12-dist-in 10.155 APE11-dist-in 12.391 APE10-dist-in 6.511 APE9-dist-in 4.173 D311N None None XRAY 3.9 0.284 0.346 A 599 538 0 0 0 0 [[186, 448]] 1.0 9mx2 AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
6PJXA 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.237 11.877 None -101.92, -82.66 -75.73, 114.06 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.8 Saltbr-in 2.36 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.846 APE11-dist-in 11.942 APE10-dist-in 6.114 APE9-dist-in 4.464 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591 542 0 0 0 0 [[186, 448]] 1.0 6pjx AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
8UAQA 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.02 12.841 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.334 Saltbr-in 3.369 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.102 APE10-dist-in 6.306 APE9-dist-in 4.174 D311N None None XRAY 2.8 0.232 0.277 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uaq AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRFA 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.213 12.885 None -116.13, -75.08 -76.38, 97.42 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.076 Saltbr-in 2.475 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.984 APE11-dist-in 12.065 APE10-dist-in 6.225 APE9-dist-in 4.119 D311N None None XRAY 2.84 0.224 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brf AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRIA 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.79 12.714 None -118.56, -79.42 -70.93, 91.99 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.802 Saltbr-in 2.649 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.133 APE11-dist-in 12.215 APE10-dist-in 6.571 APE9-dist-in 4.225 D311N None None XRAY 2.9 0.217 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bri AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
9BRJA 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.735 12.619 None -115.77, -57.96 -84.12, 93.88 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.057 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.116 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.723 APE11-dist-in 12.109 APE10-dist-in 6.414 APE9-dist-in 4.167 D311N None None XRAY 2.8 0.239 0.273 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brj AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5

AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 26
Active chains: 15
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 61.5% AF-P34947-K1A
DFGin ABAminus 5 19.2% 4WNKA
DFGin None 5 19.2% 6PJXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.267 12.797 ABAminus -122.04, -4.62 -137.77, 133.15 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.484 Saltbr-in 2.781 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.951 APE10-dist-in 6.101 APE9-dist-in 3.92 None None None XRAY 2.42 0.196 0.243 A 598 499 0 0 0 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.2e-84 288.8 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.172 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.193 Saltbr-in 3.053 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.302 APE11-dist-in 12.056 APE10-dist-in 6.23 APE9-dist-in 4.255 None None None XRAY 1.802 0.174 0.205 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnd Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.172 12.867 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.589 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.872 APE11-dist-in 12.258 APE10-dist-in 6.529 APE9-dist-in 4.181 D311N None None XRAY 2.8 0.239 0.286 A 598 501 0 0 0 0 [[186, 448]] 1.0 9ckr Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.038 13.061 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.222 Saltbr-in 2.672 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.616 APE11-dist-in 12.407 APE10-dist-in 6.563 APE9-dist-in 4.207 D311N None None XRAY 3.08 0.228 0.28 A 598 501 0 0 0 0 [[186, 448]] 1.0 9cks Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN AF-P34947-K1A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 5.488 12.674 BLAminus -115.97, -177.38 48.25, 67.07 -77.66, 16.16 284.97, 107.27 -63.58, -32.29 in-in in 8.966 Saltbr-in 2.674 HRD-in -81.4, -44.95 66.95, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 159.3 APE9-dihe-na 118.39, -174.52 APE8-dihe-in -94.59, 137.57 APE8-rot-in 303.09 APE67-dihe-inflip 95.72, -15.07 -56.34, 127.54 APE12-dist-in 10.505 APE11-dist-in 12.248 APE10-dist-in 6.215 APE9-dist-in 3.781 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K1 Homo sapiens AGC_GRK5_HUMAN AGC 6e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN AF-P34947-K3A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 6.022 12.099 BLAminus -130.04, 178.69 50.56, 62.08 -71.61, 20.06 306.44, 6.94 -60.07, -35.44 in-in in 8.543 Saltbr-in 2.615 HRD-in -88.42, -48.64 68.04, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.09, 156.11 APE9-dihe-na 120.9, -174.14 APE8-dihe-in -94.05, 138.77 APE8-rot-in 297.52 APE67-dihe-inflip 92.74, -12.69 -58.9, 127.55 APE12-dist-in 10.541 APE11-dist-in 11.976 APE10-dist-in 5.961 APE9-dist-in 3.312 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K3 Homo sapiens AGC_GRK5_HUMAN AGC 6e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9CKQA P34947 25 542 590.0 No_ligand No_ligand Active DFGin 6.036 12.85 BLAminus -128.35, 170.36 62.76, 74.57 -90.62, 17.1 285.99, 91.78 -58.04, -33.82 in-in in 9.106 Saltbr-in 2.933 HRD-in -93.54, -52.56 67.97, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.01, 171.06 APE9-dihe-na 118.15, -151.5 APE8-dihe-in -127.65, 146.62 APE8-rot-in 290.59 APE67-dihe-inflip 92.51, -30.74 -57.11, 135.04 APE12-dist-in 9.779 APE11-dist-in 12.023 APE10-dist-in 6.163 APE9-dist-in 4.116 D311N None None XRAY 2.7 0.239 0.294 A 597 490 11 0 0 0 [[186, 448]] 1.0 9ckq Homo sapiens AGC_GRK5_HUMAN AGC 7.5e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 4TNBA P34947 15 543 590.0 SGV:601 Type1 Active DFGin 5.135 12.74 BLAminus -123.5, 176.17 54.54, 74.38 -84.69, 6.5 286.26, 112.63 -51.75, -34.18 in-in in 9.001 Saltbr-in 2.528 HRD-in -77.08, -45.38 66.65, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 150.87 APE9-dihe-na 143.24, -163.75 APE8-dihe-in -110.5, 150.66 APE8-rot-in 315.23 APE67-dihe-inflip 90.86, -23.2 -67.3, 136.98 APE12-dist-in 10.739 APE11-dist-in 11.875 APE10-dist-in 5.946 APE9-dist-in 4.112 None None None XRAY 2.113 0.175 0.232 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnb Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 8UAPA P34947 25 542 590.0 W2T:601 Type1 Active DFGin 5.952 12.669 BLAminus -132.18, -179.7 52.11, 79.03 -91.08, 7.0 281.21, 78.18 -55.19, -15.59 in-in in 8.933 Saltbr-in 2.319 HRD-in -89.52, -55.99 69.41, 4.8 in-in-in SNCiii in-in ActLoopNT-in 3.075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 157.14 APE9-dihe-na 134.87, -160.65 APE8-dihe-in -105.62, 143.33 APE8-rot-in 315.67 APE67-dihe-inflip 91.84, -13.85 -56.42, 130.69 APE12-dist-in 10.242 APE11-dist-in 12.329 APE10-dist-in 6.498 APE9-dist-in 4.083 D311N None None XRAY 2.5 0.229 0.267 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uap Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.176 12.564 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.801 Saltbr-in 2.458 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.943 APE11-dist-in 12.131 APE10-dist-in 6.337 APE9-dist-in 4.122 D311N None None XRAY 2.8 0.215 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bre Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRGA P34947 25 542 590.0 A1AQ6:601 Type1 Active DFGin 5.888 12.744 BLAminus -127.15, 171.02 61.76, 75.85 -94.14, 20.1 287.82, 78.85 -68.02, -19.4 in-in in 9.043 Saltbr-in 2.346 HRD-in -85.19, -53.81 70.34, 12.77 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 160.56 APE9-dihe-na 125.86, -158.84 APE8-dihe-in -113.45, 141.13 APE8-rot-in 318.14 APE67-dihe-inflip 91.69, -20.41 -53.6, 133.88 APE12-dist-in 9.77 APE11-dist-in 12.073 APE10-dist-in 6.219 APE9-dist-in 4.083 D311N None None XRAY 2.7 0.242 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brg Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRHA P34947 25 542 590.0 A1AQ7:601 Type1 Active DFGin 6.213 12.998 BLAminus -137.89, -178.33 53.87, 65.42 -85.04, 16.09 287.04, 75.14 -57.93, -30.07 in-in in 9.364 Saltbr-in 2.788 HRD-in -82.45, -56.04 70.11, 8.28 in-in-in SNCiii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.58, 168.01 APE9-dihe-na 127.33, -166.12 APE8-dihe-in -113.88, 147.37 APE8-rot-in 307.37 APE67-dihe-inflip 89.75, -29.49 -53.29, 136.77 APE12-dist-in 10.364 APE11-dist-in 12.068 APE10-dist-in 6.136 APE9-dist-in 4.119 D311N None None XRAY 3.69 0.2 0.244 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brh Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRMA P34947 25 542 590.0 A1ARC:601 Type1 Active DFGin 5.93 12.32 BLAminus -129.54, 170.53 64.08, 75.97 -94.87, 21.89 289.68, 68.45 -68.62, -20.59 in-in in 8.627 Saltbr-in 2.58 HRD-in -82.68, -56.6 72.77, 4.07 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 165.33 APE9-dihe-na 123.74, -150.01 APE8-dihe-in -120.92, 138.81 APE8-rot-in 302.36 APE67-dihe-inflip 99.67, -19.1 -52.94, 128.15 APE12-dist-in 9.803 APE11-dist-in 12.059 APE10-dist-in 6.213 APE9-dist-in 4.157 D311N None None XRAY 2.73 0.234 0.278 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brm Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRNA P34947 25 542 590.0 A1ARD:601 Type1 Active DFGin 5.902 12.725 BLAminus -139.33, 159.94 74.16, 72.44 -89.41, 22.16 291.23, 67.98 -67.08, -25.78 in-in in 8.993 Saltbr-in 2.439 HRD-in -78.87, -49.6 65.54, 8.73 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.44, 151.94 APE9-dihe-na 136.85, -155.43 APE8-dihe-in -118.42, 144.51 APE8-rot-in 301.29 APE67-dihe-inflip 92.21, -11.38 -55.67, 128.36 APE12-dist-in 9.809 APE11-dist-in 11.996 APE10-dist-in 6.094 APE9-dist-in 4.274 D311N None None XRAY 2.9 0.209 0.256 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brn Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BROA P34947 25 542 590.0 A1ARE:601 Type1 Active DFGin 5.964 12.572 BLAminus -128.27, -178.6 50.36, 73.78 -90.4, 21.64 280.73, 75.17 -69.22, -25.34 in-in in 8.906 Saltbr-in 2.39 HRD-in -93.36, -59.82 68.46, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.17, 167.74 APE9-dihe-na 123.28, -154.67 APE8-dihe-in -122.1, 138.71 APE8-rot-in 314.65 APE67-dihe-inflip 102.22, -12.34 -51.46, 123.36 APE12-dist-in 10.277 APE11-dist-in 12.337 APE10-dist-in 6.406 APE9-dist-in 4.05 D311N None None XRAY 2.8 0.221 0.271 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bro Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9CKPA P34947 1 542 590.0 SGV:602 Type1 Active DFGin 5.386 11.98 BLAminus -132.87, 164.94 63.45, 71.08 -85.64, 18.91 320.14, 3.39 -67.22, -15.79 in-in in 8.975 Saltbr-in 3.569 HRD-in -105.81, -54.45 67.93, 0.86 in-in-in SNCiii in-in ActLoopNT-in 3.27 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.75, 161.15 APE9-dihe-na 132.47, 178.17 APE8-dihe-in -105.33, 153.16 APE8-rot-in 325.98 APE67-dihe-inflip 78.63, 4.41 -62.29, 127.28 APE12-dist-in 10.034 APE11-dist-in 12.223 APE10-dist-in 6.349 APE9-dist-in 4.192 D311N None None XRAY 2.6 0.236 0.27 A 598 538 0 0 0 0 [[186, 448]] 1.0 9ckp Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9CKOA P34947 1 542 590.0 SGV:602 Type1 Inactive DFGin 5.808 12.496 ABAminus -119.73, -59.76 -93.86, 94.44 -93.46, 16.21 299.92, 79.42 -62.04, -34.62 in-in in 8.425 Saltbr-in 2.521 HRD-in -104.67, -57.7 74.0, 4.5 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 140.14 APE9-dihe-na 146.41, -176.34 APE8-dihe-in -106.42, 130.54 APE8-rot-in 306.78 APE67-dihe-inflip 81.24, -12.9 -51.64, 146.1 APE12-dist-in 10.452 APE11-dist-in 12.118 APE10-dist-in 6.155 APE9-dist-in 3.717 None None None XRAY 2.8 0.243 0.28 A 598 540 0 0 0 0 [[186, 448]] 1.0 9cko Homo sapiens AGC_GRK5_HUMAN AGC 5.9e-84 287.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRKA P34947 25 542 590.0 A1ARA:601 Type1 Inactive DFGin 5.999 12.725 ABAminus -113.29, -59.28 -86.52, 97.64 -98.22, 23.89 284.55, 73.36 -66.95, -28.05 in-in in 8.886 Saltbr-in 2.356 HRD-in -84.62, -58.9 74.96, -0.86 in-in-in SNCiii in-in ActLoopNT-in 3.06 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.94, 168.36 APE9-dihe-na 122.17, -155.18 APE8-dihe-in -114.33, 143.85 APE8-rot-in 306.85 APE67-dihe-inflip 94.43, -16.31 -58.15, 132.79 APE12-dist-in 9.666 APE11-dist-in 11.73 APE10-dist-in 6.061 APE9-dist-in 4.128 D311N None None XRAY 2.7 0.223 0.276 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brk Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRLA P34947 25 542 590.0 A1ARB:601 Type1 Inactive DFGin 5.691 12.023 ABAminus -103.25, -52.89 -74.4, 160.18 -158.5, 11.72 277.51, 97.57 -69.39, -26.51 in-in in 8.836 Saltbr-in 2.354 HRD-in -84.95, -56.21 70.99, 10.31 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 162.58 APE9-dihe-na 130.63, -156.95 APE8-dihe-in -113.5, 144.35 APE8-rot-in 307.43 APE67-dihe-inflip 83.43, -12.88 -53.97, 135.79 APE12-dist-in 9.714 APE11-dist-in 11.875 APE10-dist-in 6.043 APE9-dist-in 4.223 D311N None None XRAY 2.73 0.231 0.275 A 598 501 0 0 0 0 [[186, 448]] 1.0 9brl Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.253 12.479 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.91 Saltbr-in 3.037 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.932 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brp Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9MX2A P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.528 11.483 BLAminus -134.92, 166.93 57.12, 70.75 -87.84, 20.9 322.36, 5.46 -68.95, -14.98 in-out in 8.353 Saltbr-out 3.626 HRD-in -110.96, -57.41 68.72, 2.93 out-in-in SNCoii in-in ActLoopNT-in 3.364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.2, 161.4 APE9-dihe-na 129.58, 177.82 APE8-dihe-in -100.27, 150.38 APE8-rot-in 311.4 APE67-dihe-inflip 86.26, -1.66 -66.59, 129.67 APE12-dist-in 10.155 APE11-dist-in 12.391 APE10-dist-in 6.511 APE9-dist-in 4.173 D311N None None XRAY 3.9 0.284 0.346 A 599 538 0 0 0 0 [[186, 448]] 1.0 9mx2 Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 6PJXA P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.237 11.877 None -101.92, -82.66 -75.73, 114.06 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.8 Saltbr-in 2.36 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.846 APE11-dist-in 11.942 APE10-dist-in 6.114 APE9-dist-in 4.464 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591 542 0 0 0 0 [[186, 448]] 1.0 6pjx Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.02 12.841 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.334 Saltbr-in 3.369 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.102 APE10-dist-in 6.306 APE9-dist-in 4.174 D311N None None XRAY 2.8 0.232 0.277 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uaq Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRFA P34947 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.213 12.885 None -116.13, -75.08 -76.38, 97.42 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.076 Saltbr-in 2.475 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.984 APE11-dist-in 12.065 APE10-dist-in 6.225 APE9-dist-in 4.119 D311N None None XRAY 2.84 0.224 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brf Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRIA P34947 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.79 12.714 None -118.56, -79.42 -70.93, 91.99 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.802 Saltbr-in 2.649 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.133 APE11-dist-in 12.215 APE10-dist-in 6.571 APE9-dist-in 4.225 D311N None None XRAY 2.9 0.217 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bri Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5_HUMAN 9BRJA P34947 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.735 12.619 None -115.77, -57.96 -84.12, 93.88 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.057 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.116 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.723 APE11-dist-in 12.109 APE10-dist-in 6.414 APE9-dist-in 4.167 D311N None None XRAY 2.8 0.239 0.273 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brj Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5

AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 1
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 100.0% 4WNKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.267 12.797 ABAminus -122.04, -4.62 -137.77, 133.15 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.484 Saltbr-in 2.781 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.951 APE10-dist-in 6.101 APE9-dist-in 3.92 None None None XRAY 2.42 0.196 0.243 A 598 499 0 0 0 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.2e-84 288.8 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5