AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 25
Active chains: 15
Uniprot: GRK5_HUMAN
Kinase Domain Residues: 186 - 448
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 64.0% AF-P34947-K1A
DFGin None 5 20.0% 6PJXA
DFGin ABAminus 4 16.0% 9BRKA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK5 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.1718 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.1929 Saltbr-in 3.0526 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.3015 APE11-dist-in 12.0563 APE10-dist-in 6.2302 APE9-dist-in 4.2553 None None None XRAY 1.802 0.174 0.205 A 590.0 529.0 0 27 27 0 [[186, 448]] 1.0 4tnd AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.1719 12.8672 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.5891 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.9677 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.8722 APE11-dist-in 12.2584 APE10-dist-in 6.5289 APE9-dist-in 4.1807 D311N None None XRAY 2.8 0.239 0.286 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9ckr AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.0382 13.0612 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.2222 Saltbr-in 2.6724 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.9627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.6156 APE11-dist-in 12.4068 APE10-dist-in 6.5628 APE9-dist-in 4.2067 D311N None None XRAY 3.08 0.228 0.28 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9cks AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 AF-P34947-K1A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 5.488 12.6736 BLAminus -115.97, -177.38 48.25, 67.07 -77.66, 16.16 284.97, 107.27 -63.58, -32.29 in-in in 8.9664 Saltbr-in 2.674 HRD-in -81.4, -44.95 66.95, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.8959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 159.3 APE9-dihe-na 118.39, -174.52 APE8-dihe-in -94.59, 137.57 APE8-rot-in 303.09 APE67-dihe-inflip 95.72, -15.07 -56.34, 127.54 APE12-dist-in 10.5047 APE11-dist-in 12.2476 APE10-dist-in 6.2146 APE9-dist-in 3.7811 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 27 27 0 [[186, 448]] 1.0 AF-P34947-K1 AGC_GRK5_HUMAN AGC 6e-85 290.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 AF-P34947-K3A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 6.0217 12.0992 BLAminus -130.04, 178.69 50.56, 62.08 -71.61, 20.06 306.44, 6.94 -60.07, -35.44 in-in in 8.5425 Saltbr-in 2.6154 HRD-in -88.42, -48.64 68.04, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.9566 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.09, 156.11 APE9-dihe-na 120.9, -174.14 APE8-dihe-in -94.05, 138.77 APE8-rot-in 297.52 APE67-dihe-inflip 92.74, -12.69 -58.9, 127.55 APE12-dist-in 10.5409 APE11-dist-in 11.9762 APE10-dist-in 5.9613 APE9-dist-in 3.3122 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 27 27 0 [[186, 448]] 1.0 AF-P34947-K3 AGC_GRK5_HUMAN AGC 6e-85 290.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9CKQA P34947 25 542 590.0 No_ligand No_ligand Active DFGin 6.0358 12.8495 BLAminus -128.35, 170.36 62.76, 74.57 -90.62, 17.1 285.99, 91.78 -58.04, -33.82 in-in in 9.1056 Saltbr-in 2.9331 HRD-in -93.54, -52.56 67.97, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.9462 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.01, 171.06 APE9-dihe-na 118.15, -151.5 APE8-dihe-in -127.65, 146.62 APE8-rot-in 290.59 APE67-dihe-inflip 92.51, -30.74 -57.11, 135.04 APE12-dist-in 9.7791 APE11-dist-in 12.0232 APE10-dist-in 6.1634 APE9-dist-in 4.1157 D311N None None XRAY 2.7 0.239 0.294 A 597.0 490.0 11 27 27 0 [[186, 448]] 1.0 9ckq AGC_GRK5_HUMAN AGC 7.5e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 4TNBA P34947 15 543 590.0 SGV:601 Type1 Active DFGin 5.1347 12.7402 BLAminus -123.5, 176.17 54.54, 74.38 -84.69, 6.5 286.26, 112.63 -51.75, -34.18 in-in in 9.0014 Saltbr-in 2.528 HRD-in -77.08, -45.38 66.65, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 150.87 APE9-dihe-na 143.24, -163.75 APE8-dihe-in -110.5, 150.66 APE8-rot-in 315.23 APE67-dihe-inflip 90.86, -23.2 -67.3, 136.98 APE12-dist-in 10.7387 APE11-dist-in 11.8747 APE10-dist-in 5.9463 APE9-dist-in 4.1118 None None None XRAY 2.113 0.175 0.232 A 590.0 529.0 0 27 27 0 [[186, 448]] 1.0 4tnb AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 8UAPA P34947 25 542 590.0 W2T:601 Type1 Active DFGin 5.9519 12.6688 BLAminus -132.18, -179.7 52.11, 79.03 -91.08, 7.0 281.21, 78.18 -55.19, -15.59 in-in in 8.933 Saltbr-in 2.3194 HRD-in -89.52, -55.99 69.41, 4.8 in-in-in SNCiii in-in ActLoopNT-in 3.0747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 157.14 APE9-dihe-na 134.87, -160.65 APE8-dihe-in -105.62, 143.33 APE8-rot-in 315.67 APE67-dihe-inflip 91.84, -13.85 -56.42, 130.69 APE12-dist-in 10.2424 APE11-dist-in 12.3294 APE10-dist-in 6.4983 APE9-dist-in 4.0827 D311N None None XRAY 2.5 0.229 0.267 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uap AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.1758 12.5641 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.8006 Saltbr-in 2.4578 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.1273 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.9432 APE11-dist-in 12.1314 APE10-dist-in 6.3367 APE9-dist-in 4.1222 D311N None None XRAY 2.8 0.215 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bre AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRGA P34947 25 542 590.0 A1AQ6:601 Type1 Active DFGin 5.8882 12.7443 BLAminus -127.15, 171.02 61.76, 75.85 -94.14, 20.1 287.82, 78.85 -68.02, -19.4 in-in in 9.0433 Saltbr-in 2.3465 HRD-in -85.19, -53.81 70.34, 12.77 in-in-in SNCiii in-in ActLoopNT-in 3.1046 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 160.56 APE9-dihe-na 125.86, -158.84 APE8-dihe-in -113.45, 141.13 APE8-rot-in 318.14 APE67-dihe-inflip 91.69, -20.41 -53.6, 133.88 APE12-dist-in 9.7697 APE11-dist-in 12.0735 APE10-dist-in 6.2186 APE9-dist-in 4.0834 D311N None None XRAY 2.7 0.242 0.277 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brg AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRHA P34947 25 542 590.0 A1AQ7:601 Type1 Active DFGin 6.2132 12.9978 BLAminus -137.89, -178.33 53.87, 65.42 -85.04, 16.09 287.04, 75.14 -57.93, -30.07 in-in in 9.3637 Saltbr-in 2.7875 HRD-in -82.45, -56.04 70.11, 8.28 in-in-in SNCiii in-in ActLoopNT-in 3.0985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.58, 168.01 APE9-dihe-na 127.33, -166.12 APE8-dihe-in -113.88, 147.37 APE8-rot-in 307.37 APE67-dihe-inflip 89.75, -29.49 -53.29, 136.77 APE12-dist-in 10.3639 APE11-dist-in 12.0679 APE10-dist-in 6.1363 APE9-dist-in 4.1188 D311N None None XRAY 3.69 0.2 0.244 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brh AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRMA P34947 25 542 590.0 A1ARC:601 Type1 Active DFGin 5.9298 12.3198 BLAminus -129.54, 170.53 64.08, 75.97 -94.87, 21.89 289.68, 68.45 -68.62, -20.59 in-in in 8.6269 Saltbr-in 2.5804 HRD-in -82.68, -56.6 72.77, 4.07 in-in-in SNCiii in-in ActLoopNT-in 3.0386 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 165.33 APE9-dihe-na 123.74, -150.01 APE8-dihe-in -120.92, 138.81 APE8-rot-in 302.36 APE67-dihe-inflip 99.67, -19.1 -52.94, 128.15 APE12-dist-in 9.8026 APE11-dist-in 12.0589 APE10-dist-in 6.2126 APE9-dist-in 4.1567 D311N None None XRAY 2.73 0.234 0.278 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brm AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRNA P34947 25 542 590.0 A1ARD:601 Type1 Active DFGin 5.9016 12.7251 BLAminus -139.33, 159.94 74.16, 72.44 -89.41, 22.16 291.23, 67.98 -67.08, -25.78 in-in in 8.9931 Saltbr-in 2.4388 HRD-in -78.87, -49.6 65.54, 8.73 in-in-in SNCiii in-in ActLoopNT-in 2.9886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.44, 151.94 APE9-dihe-na 136.85, -155.43 APE8-dihe-in -118.42, 144.51 APE8-rot-in 301.29 APE67-dihe-inflip 92.21, -11.38 -55.67, 128.36 APE12-dist-in 9.8088 APE11-dist-in 11.9957 APE10-dist-in 6.0938 APE9-dist-in 4.2745 D311N None None XRAY 2.9 0.209 0.256 A 598.0 502.0 0 27 27 0 [[186, 448]] 1.0 9brn AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BROA P34947 25 542 590.0 A1ARE:601 Type1 Active DFGin 5.9636 12.5715 BLAminus -128.27, -178.6 50.36, 73.78 -90.4, 21.64 280.73, 75.17 -69.22, -25.34 in-in in 8.9064 Saltbr-in 2.3898 HRD-in -93.36, -59.82 68.46, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.8302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.17, 167.74 APE9-dihe-na 123.28, -154.67 APE8-dihe-in -122.1, 138.71 APE8-rot-in 314.65 APE67-dihe-inflip 102.22, -12.34 -51.46, 123.36 APE12-dist-in 10.2765 APE11-dist-in 12.3372 APE10-dist-in 6.4064 APE9-dist-in 4.0502 D311N None None XRAY 2.8 0.221 0.271 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bro AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9CKPA P34947 1 542 590.0 SGV:602 Type1 Active DFGin 5.3856 11.9802 BLAminus -132.87, 164.94 63.45, 71.08 -85.64, 18.91 320.14, 3.39 -67.22, -15.79 in-in in 8.9749 Saltbr-in 3.5693 HRD-in -105.81, -54.45 67.93, 0.86 in-in-in SNCiii in-in ActLoopNT-in 3.2698 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.75, 161.15 APE9-dihe-na 132.47, 178.17 APE8-dihe-in -105.33, 153.16 APE8-rot-in 325.98 APE67-dihe-inflip 78.63, 4.41 -62.29, 127.28 APE12-dist-in 10.0337 APE11-dist-in 12.2231 APE10-dist-in 6.3492 APE9-dist-in 4.1919 D311N None None XRAY 2.6 0.236 0.27 A 598.0 538.0 0 27 27 0 [[186, 448]] 1.0 9ckp AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9CKOA P34947 1 542 590.0 SGV:602 Type1 Inactive DFGin 5.808 12.4965 ABAminus -119.73, -59.76 -93.86, 94.44 -93.46, 16.21 299.92, 79.42 -62.04, -34.62 in-in in 8.4255 Saltbr-in 2.5213 HRD-in -104.67, -57.7 74.0, 4.5 in-in-in SNCiii in-in ActLoopNT-in 2.8204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 140.14 APE9-dihe-na 146.41, -176.34 APE8-dihe-in -106.42, 130.54 APE8-rot-in 306.78 APE67-dihe-inflip 81.24, -12.9 -51.64, 146.1 APE12-dist-in 10.4519 APE11-dist-in 12.1181 APE10-dist-in 6.1554 APE9-dist-in 3.7174 None None None XRAY 2.8 0.243 0.28 A 598.0 540.0 0 27 27 0 [[186, 448]] 1.0 9cko AGC_GRK5_HUMAN AGC 5.9e-84 287.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRKA P34947 25 542 590.0 A1ARA:601 Type1 Inactive DFGin 5.9989 12.7247 ABAminus -113.29, -59.28 -86.52, 97.64 -98.22, 23.89 284.55, 73.36 -66.95, -28.05 in-in in 8.8856 Saltbr-in 2.3562 HRD-in -84.62, -58.9 74.96, -0.86 in-in-in SNCiii in-in ActLoopNT-in 3.0603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.94, 168.36 APE9-dihe-na 122.17, -155.18 APE8-dihe-in -114.33, 143.85 APE8-rot-in 306.85 APE67-dihe-inflip 94.43, -16.31 -58.15, 132.79 APE12-dist-in 9.6664 APE11-dist-in 11.7296 APE10-dist-in 6.0615 APE9-dist-in 4.128 D311N None None XRAY 2.7 0.223 0.276 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brk AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRLA P34947 25 542 590.0 A1ARB:601 Type1 Inactive DFGin 5.6912 12.0225 ABAminus -103.25, -52.89 -74.4, 160.18 -158.5, 11.72 277.51, 97.57 -69.39, -26.51 in-in in 8.8365 Saltbr-in 2.3539 HRD-in -84.95, -56.21 70.99, 10.31 in-in-in SNCiii in-in ActLoopNT-in 3.0078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 162.58 APE9-dihe-na 130.63, -156.95 APE8-dihe-in -113.5, 144.35 APE8-rot-in 307.43 APE67-dihe-inflip 83.43, -12.88 -53.97, 135.79 APE12-dist-in 9.7136 APE11-dist-in 11.8747 APE10-dist-in 6.0426 APE9-dist-in 4.2235 D311N None None XRAY 2.73 0.231 0.275 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9brl AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.2535 12.4795 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.9098 Saltbr-in 3.0371 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.1048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.9322 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598.0 502.0 0 27 27 0 [[186, 448]] 1.0 9brp AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9MX2A P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.5284 11.483 BLAminus -134.92, 166.93 57.12, 70.75 -87.84, 20.9 322.36, 5.46 -68.95, -14.98 in-out in 8.3529 Saltbr-out 3.6263 HRD-in -110.96, -57.41 68.72, 2.93 out-in-in SNCoii in-in ActLoopNT-in 3.3639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.2, 161.4 APE9-dihe-na 129.58, 177.82 APE8-dihe-in -100.27, 150.38 APE8-rot-in 311.4 APE67-dihe-inflip 86.26, -1.66 -66.59, 129.67 APE12-dist-in 10.1545 APE11-dist-in 12.3907 APE10-dist-in 6.5105 APE9-dist-in 4.1735 D311N None None XRAY 3.9 0.284 0.346 A 599.0 538.0 0 27 27 0 [[186, 448]] 1.0 9mx2 AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 6PJXA P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.2367 11.8767 None -101.92, -82.66 -75.73, 114.06 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.7999 Saltbr-in 2.3601 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.8132 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.8463 APE11-dist-in 11.9422 APE10-dist-in 6.1145 APE9-dist-in 4.4639 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591.0 542.0 0 27 27 0 [[186, 448]] 1.0 6pjx AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.0198 12.8412 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.3335 Saltbr-in 3.3688 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.0372 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.1019 APE10-dist-in 6.3064 APE9-dist-in 4.1737 D311N None None XRAY 2.8 0.232 0.277 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uaq AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRFA P34947 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.2131 12.8852 None -116.13, -75.08 -76.38, 97.42 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.0758 Saltbr-in 2.4746 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.0583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.9844 APE11-dist-in 12.0653 APE10-dist-in 6.2254 APE9-dist-in 4.1192 D311N None None XRAY 2.84 0.224 0.277 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brf AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRIA P34947 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.7901 12.7141 None -118.56, -79.42 -70.93, 91.99 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.8021 Saltbr-in 2.6488 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.1673 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.1331 APE11-dist-in 12.2149 APE10-dist-in 6.5714 APE9-dist-in 4.2246 D311N None None XRAY 2.9 0.217 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bri AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 9BRJA P34947 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.7352 12.6187 None -115.77, -57.96 -84.12, 93.88 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.0567 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.1163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.7235 APE11-dist-in 12.1088 APE10-dist-in 6.4144 APE9-dist-in 4.1673 D311N None None XRAY 2.8 0.239 0.273 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brj AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5

AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 26
Active chains: 15
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 61.5% AF-P34947-K1A
DFGin ABAminus 5 19.2% 4WNKA
DFGin None 5 19.2% 6PJXA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK5 GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.2666 12.7972 ABAminus -122.04, -4.62 -137.77, 133.15 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.4843 Saltbr-in 2.7813 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.0303 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.9507 APE10-dist-in 6.1011 APE9-dist-in 3.9199 None None None XRAY 2.42 0.196 0.243 A 598.0 499.0 0 27 27 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.2e-84 288.8 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.1718 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.1929 Saltbr-in 3.0526 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.3015 APE11-dist-in 12.0563 APE10-dist-in 6.2302 APE9-dist-in 4.2553 None None None XRAY 1.802 0.174 0.205 A 590.0 529.0 0 27 27 0 [[186, 448]] 1.0 4tnd Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.1719 12.8672 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.5891 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.9677 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.8722 APE11-dist-in 12.2584 APE10-dist-in 6.5289 APE9-dist-in 4.1807 D311N None None XRAY 2.8 0.239 0.286 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9ckr Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.0382 13.0612 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.2222 Saltbr-in 2.6724 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.9627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.6156 APE11-dist-in 12.4068 APE10-dist-in 6.5628 APE9-dist-in 4.2067 D311N None None XRAY 3.08 0.228 0.28 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9cks Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN AF-P34947-K1A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 5.488 12.6736 BLAminus -115.97, -177.38 48.25, 67.07 -77.66, 16.16 284.97, 107.27 -63.58, -32.29 in-in in 8.9664 Saltbr-in 2.674 HRD-in -81.4, -44.95 66.95, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.8959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 159.3 APE9-dihe-na 118.39, -174.52 APE8-dihe-in -94.59, 137.57 APE8-rot-in 303.09 APE67-dihe-inflip 95.72, -15.07 -56.34, 127.54 APE12-dist-in 10.5047 APE11-dist-in 12.2476 APE10-dist-in 6.2146 APE9-dist-in 3.7811 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 27 27 0 [[186, 448]] 1.0 AF-P34947-K1 Homo sapiens AGC_GRK5_HUMAN AGC 6e-85 290.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN AF-P34947-K3A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 6.0217 12.0992 BLAminus -130.04, 178.69 50.56, 62.08 -71.61, 20.06 306.44, 6.94 -60.07, -35.44 in-in in 8.5425 Saltbr-in 2.6154 HRD-in -88.42, -48.64 68.04, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.9566 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.09, 156.11 APE9-dihe-na 120.9, -174.14 APE8-dihe-in -94.05, 138.77 APE8-rot-in 297.52 APE67-dihe-inflip 92.74, -12.69 -58.9, 127.55 APE12-dist-in 10.5409 APE11-dist-in 11.9762 APE10-dist-in 5.9613 APE9-dist-in 3.3122 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 27 27 0 [[186, 448]] 1.0 AF-P34947-K3 Homo sapiens AGC_GRK5_HUMAN AGC 6e-85 290.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9CKQA P34947 25 542 590.0 No_ligand No_ligand Active DFGin 6.0358 12.8495 BLAminus -128.35, 170.36 62.76, 74.57 -90.62, 17.1 285.99, 91.78 -58.04, -33.82 in-in in 9.1056 Saltbr-in 2.9331 HRD-in -93.54, -52.56 67.97, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.9462 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.01, 171.06 APE9-dihe-na 118.15, -151.5 APE8-dihe-in -127.65, 146.62 APE8-rot-in 290.59 APE67-dihe-inflip 92.51, -30.74 -57.11, 135.04 APE12-dist-in 9.7791 APE11-dist-in 12.0232 APE10-dist-in 6.1634 APE9-dist-in 4.1157 D311N None None XRAY 2.7 0.239 0.294 A 597.0 490.0 11 27 27 0 [[186, 448]] 1.0 9ckq Homo sapiens AGC_GRK5_HUMAN AGC 7.5e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 4TNBA P34947 15 543 590.0 SGV:601 Type1 Active DFGin 5.1347 12.7402 BLAminus -123.5, 176.17 54.54, 74.38 -84.69, 6.5 286.26, 112.63 -51.75, -34.18 in-in in 9.0014 Saltbr-in 2.528 HRD-in -77.08, -45.38 66.65, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 150.87 APE9-dihe-na 143.24, -163.75 APE8-dihe-in -110.5, 150.66 APE8-rot-in 315.23 APE67-dihe-inflip 90.86, -23.2 -67.3, 136.98 APE12-dist-in 10.7387 APE11-dist-in 11.8747 APE10-dist-in 5.9463 APE9-dist-in 4.1118 None None None XRAY 2.113 0.175 0.232 A 590.0 529.0 0 27 27 0 [[186, 448]] 1.0 4tnb Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 8UAPA P34947 25 542 590.0 W2T:601 Type1 Active DFGin 5.9519 12.6688 BLAminus -132.18, -179.7 52.11, 79.03 -91.08, 7.0 281.21, 78.18 -55.19, -15.59 in-in in 8.933 Saltbr-in 2.3194 HRD-in -89.52, -55.99 69.41, 4.8 in-in-in SNCiii in-in ActLoopNT-in 3.0747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 157.14 APE9-dihe-na 134.87, -160.65 APE8-dihe-in -105.62, 143.33 APE8-rot-in 315.67 APE67-dihe-inflip 91.84, -13.85 -56.42, 130.69 APE12-dist-in 10.2424 APE11-dist-in 12.3294 APE10-dist-in 6.4983 APE9-dist-in 4.0827 D311N None None XRAY 2.5 0.229 0.267 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uap Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.1758 12.5641 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.8006 Saltbr-in 2.4578 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.1273 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.9432 APE11-dist-in 12.1314 APE10-dist-in 6.3367 APE9-dist-in 4.1222 D311N None None XRAY 2.8 0.215 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bre Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRGA P34947 25 542 590.0 A1AQ6:601 Type1 Active DFGin 5.8882 12.7443 BLAminus -127.15, 171.02 61.76, 75.85 -94.14, 20.1 287.82, 78.85 -68.02, -19.4 in-in in 9.0433 Saltbr-in 2.3465 HRD-in -85.19, -53.81 70.34, 12.77 in-in-in SNCiii in-in ActLoopNT-in 3.1046 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 160.56 APE9-dihe-na 125.86, -158.84 APE8-dihe-in -113.45, 141.13 APE8-rot-in 318.14 APE67-dihe-inflip 91.69, -20.41 -53.6, 133.88 APE12-dist-in 9.7697 APE11-dist-in 12.0735 APE10-dist-in 6.2186 APE9-dist-in 4.0834 D311N None None XRAY 2.7 0.242 0.277 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brg Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRHA P34947 25 542 590.0 A1AQ7:601 Type1 Active DFGin 6.2132 12.9978 BLAminus -137.89, -178.33 53.87, 65.42 -85.04, 16.09 287.04, 75.14 -57.93, -30.07 in-in in 9.3637 Saltbr-in 2.7875 HRD-in -82.45, -56.04 70.11, 8.28 in-in-in SNCiii in-in ActLoopNT-in 3.0985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.58, 168.01 APE9-dihe-na 127.33, -166.12 APE8-dihe-in -113.88, 147.37 APE8-rot-in 307.37 APE67-dihe-inflip 89.75, -29.49 -53.29, 136.77 APE12-dist-in 10.3639 APE11-dist-in 12.0679 APE10-dist-in 6.1363 APE9-dist-in 4.1188 D311N None None XRAY 3.69 0.2 0.244 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brh Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRMA P34947 25 542 590.0 A1ARC:601 Type1 Active DFGin 5.9298 12.3198 BLAminus -129.54, 170.53 64.08, 75.97 -94.87, 21.89 289.68, 68.45 -68.62, -20.59 in-in in 8.6269 Saltbr-in 2.5804 HRD-in -82.68, -56.6 72.77, 4.07 in-in-in SNCiii in-in ActLoopNT-in 3.0386 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 165.33 APE9-dihe-na 123.74, -150.01 APE8-dihe-in -120.92, 138.81 APE8-rot-in 302.36 APE67-dihe-inflip 99.67, -19.1 -52.94, 128.15 APE12-dist-in 9.8026 APE11-dist-in 12.0589 APE10-dist-in 6.2126 APE9-dist-in 4.1567 D311N None None XRAY 2.73 0.234 0.278 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brm Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRNA P34947 25 542 590.0 A1ARD:601 Type1 Active DFGin 5.9016 12.7251 BLAminus -139.33, 159.94 74.16, 72.44 -89.41, 22.16 291.23, 67.98 -67.08, -25.78 in-in in 8.9931 Saltbr-in 2.4388 HRD-in -78.87, -49.6 65.54, 8.73 in-in-in SNCiii in-in ActLoopNT-in 2.9886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.44, 151.94 APE9-dihe-na 136.85, -155.43 APE8-dihe-in -118.42, 144.51 APE8-rot-in 301.29 APE67-dihe-inflip 92.21, -11.38 -55.67, 128.36 APE12-dist-in 9.8088 APE11-dist-in 11.9957 APE10-dist-in 6.0938 APE9-dist-in 4.2745 D311N None None XRAY 2.9 0.209 0.256 A 598.0 502.0 0 27 27 0 [[186, 448]] 1.0 9brn Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BROA P34947 25 542 590.0 A1ARE:601 Type1 Active DFGin 5.9636 12.5715 BLAminus -128.27, -178.6 50.36, 73.78 -90.4, 21.64 280.73, 75.17 -69.22, -25.34 in-in in 8.9064 Saltbr-in 2.3898 HRD-in -93.36, -59.82 68.46, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.8302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.17, 167.74 APE9-dihe-na 123.28, -154.67 APE8-dihe-in -122.1, 138.71 APE8-rot-in 314.65 APE67-dihe-inflip 102.22, -12.34 -51.46, 123.36 APE12-dist-in 10.2765 APE11-dist-in 12.3372 APE10-dist-in 6.4064 APE9-dist-in 4.0502 D311N None None XRAY 2.8 0.221 0.271 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bro Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9CKPA P34947 1 542 590.0 SGV:602 Type1 Active DFGin 5.3856 11.9802 BLAminus -132.87, 164.94 63.45, 71.08 -85.64, 18.91 320.14, 3.39 -67.22, -15.79 in-in in 8.9749 Saltbr-in 3.5693 HRD-in -105.81, -54.45 67.93, 0.86 in-in-in SNCiii in-in ActLoopNT-in 3.2698 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.75, 161.15 APE9-dihe-na 132.47, 178.17 APE8-dihe-in -105.33, 153.16 APE8-rot-in 325.98 APE67-dihe-inflip 78.63, 4.41 -62.29, 127.28 APE12-dist-in 10.0337 APE11-dist-in 12.2231 APE10-dist-in 6.3492 APE9-dist-in 4.1919 D311N None None XRAY 2.6 0.236 0.27 A 598.0 538.0 0 27 27 0 [[186, 448]] 1.0 9ckp Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9CKOA P34947 1 542 590.0 SGV:602 Type1 Inactive DFGin 5.808 12.4965 ABAminus -119.73, -59.76 -93.86, 94.44 -93.46, 16.21 299.92, 79.42 -62.04, -34.62 in-in in 8.4255 Saltbr-in 2.5213 HRD-in -104.67, -57.7 74.0, 4.5 in-in-in SNCiii in-in ActLoopNT-in 2.8204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 140.14 APE9-dihe-na 146.41, -176.34 APE8-dihe-in -106.42, 130.54 APE8-rot-in 306.78 APE67-dihe-inflip 81.24, -12.9 -51.64, 146.1 APE12-dist-in 10.4519 APE11-dist-in 12.1181 APE10-dist-in 6.1554 APE9-dist-in 3.7174 None None None XRAY 2.8 0.243 0.28 A 598.0 540.0 0 27 27 0 [[186, 448]] 1.0 9cko Homo sapiens AGC_GRK5_HUMAN AGC 5.9e-84 287.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRKA P34947 25 542 590.0 A1ARA:601 Type1 Inactive DFGin 5.9989 12.7247 ABAminus -113.29, -59.28 -86.52, 97.64 -98.22, 23.89 284.55, 73.36 -66.95, -28.05 in-in in 8.8856 Saltbr-in 2.3562 HRD-in -84.62, -58.9 74.96, -0.86 in-in-in SNCiii in-in ActLoopNT-in 3.0603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.94, 168.36 APE9-dihe-na 122.17, -155.18 APE8-dihe-in -114.33, 143.85 APE8-rot-in 306.85 APE67-dihe-inflip 94.43, -16.31 -58.15, 132.79 APE12-dist-in 9.6664 APE11-dist-in 11.7296 APE10-dist-in 6.0615 APE9-dist-in 4.128 D311N None None XRAY 2.7 0.223 0.276 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brk Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRLA P34947 25 542 590.0 A1ARB:601 Type1 Inactive DFGin 5.6912 12.0225 ABAminus -103.25, -52.89 -74.4, 160.18 -158.5, 11.72 277.51, 97.57 -69.39, -26.51 in-in in 8.8365 Saltbr-in 2.3539 HRD-in -84.95, -56.21 70.99, 10.31 in-in-in SNCiii in-in ActLoopNT-in 3.0078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 162.58 APE9-dihe-na 130.63, -156.95 APE8-dihe-in -113.5, 144.35 APE8-rot-in 307.43 APE67-dihe-inflip 83.43, -12.88 -53.97, 135.79 APE12-dist-in 9.7136 APE11-dist-in 11.8747 APE10-dist-in 6.0426 APE9-dist-in 4.2235 D311N None None XRAY 2.73 0.231 0.275 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9brl Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.2535 12.4795 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.9098 Saltbr-in 3.0371 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.1048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.9322 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598.0 502.0 0 27 27 0 [[186, 448]] 1.0 9brp Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9MX2A P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.5284 11.483 BLAminus -134.92, 166.93 57.12, 70.75 -87.84, 20.9 322.36, 5.46 -68.95, -14.98 in-out in 8.3529 Saltbr-out 3.6263 HRD-in -110.96, -57.41 68.72, 2.93 out-in-in SNCoii in-in ActLoopNT-in 3.3639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.2, 161.4 APE9-dihe-na 129.58, 177.82 APE8-dihe-in -100.27, 150.38 APE8-rot-in 311.4 APE67-dihe-inflip 86.26, -1.66 -66.59, 129.67 APE12-dist-in 10.1545 APE11-dist-in 12.3907 APE10-dist-in 6.5105 APE9-dist-in 4.1735 D311N None None XRAY 3.9 0.284 0.346 A 599.0 538.0 0 27 27 0 [[186, 448]] 1.0 9mx2 Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 6PJXA P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.2367 11.8767 None -101.92, -82.66 -75.73, 114.06 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.7999 Saltbr-in 2.3601 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.8132 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.8463 APE11-dist-in 11.9422 APE10-dist-in 6.1145 APE9-dist-in 4.4639 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591.0 542.0 0 27 27 0 [[186, 448]] 1.0 6pjx Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.0198 12.8412 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.3335 Saltbr-in 3.3688 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.0372 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.1019 APE10-dist-in 6.3064 APE9-dist-in 4.1737 D311N None None XRAY 2.8 0.232 0.277 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uaq Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRFA P34947 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.2131 12.8852 None -116.13, -75.08 -76.38, 97.42 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.0758 Saltbr-in 2.4746 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.0583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.9844 APE11-dist-in 12.0653 APE10-dist-in 6.2254 APE9-dist-in 4.1192 D311N None None XRAY 2.84 0.224 0.277 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brf Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRIA P34947 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.7901 12.7141 None -118.56, -79.42 -70.93, 91.99 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.8021 Saltbr-in 2.6488 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.1673 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.1331 APE11-dist-in 12.2149 APE10-dist-in 6.5714 APE9-dist-in 4.2246 D311N None None XRAY 2.9 0.217 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bri Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
GRK5 GRK5_HUMAN 9BRJA P34947 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.7352 12.6187 None -115.77, -57.96 -84.12, 93.88 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.0567 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.1163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.7235 APE11-dist-in 12.1088 APE10-dist-in 6.4144 APE9-dist-in 4.1673 D311N None None XRAY 2.8 0.239 0.273 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9brj Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5

AGC_GRK5 (G protein-coupled receptor kinase 5)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 100.0% 4WNKA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK5 GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.2666 12.7972 ABAminus -122.04, -4.62 -137.77, 133.15 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.4843 Saltbr-in 2.7813 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.0303 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.9507 APE10-dist-in 6.1011 APE9-dist-in 3.9199 None None None XRAY 2.42 0.196 0.243 A 598.0 499.0 0 27 27 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.2e-84 288.8 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5